Tesis: "Activity of sort"

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Kimball, Ryan S. "Prediction of Clinical Symptoms and Psychological Flexibility Using a Novel Values Card Sort Activity". OpenSIUC, 2018. https://opensiuc.lib.siu.edu/theses/2409.

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Values are directly relevant in a number of theoretical orientations in psychology, including Acceptance and Commitment Therapy (ACT). In ACT, clarification of one’s personal values is paramount. The present study examined the ability to predict clinical symptoms and psychological flexibility using variables derived from one’s performance on the ACT Values Card Sort (ACT-VCS), a novel values clarification exercise. The independent variables, obtained from the ACT-VCS, included 1) the number of values endorsed as very important in the initial sort (i.e., valuing propensity), 2) the number of values domains represented in the final sort (i.e., values diversity), and 3) the extent to which one’s values were oriented toward uncontrollable experiences (i.e., control agenda endorsement). Three hierarchical regressions were conducted to examine the extent to which these three predictors accounted for the variance in scores of a) depression, anxiety, and stress, b) psychological flexibility, and c) psychological inflexibility. The psychological flexibility model was significant (∆R squared = .25 (F (3, 69) = 12.20, p < .001) with valuing propensity (squared semi-partial correlation r = .13, p < .001) and control agenda endorsement (squared semi-partial correlation r = .05, p < .01), but not values diversity, independently accounting for a significant portion of the variance. Prior therapy experience moderated some of these relationships. These findings provide preliminary evidence for using performance variables from the ACT-VCS to predict clinical variables.

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2

Chay, Claire. "Le travail des déchets : regards croisés sur une activité industrielle et environnementale". Thesis, Toulouse 2, 2015. http://www.theses.fr/2015TOU20084.

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Cette thèse appréhende le travail des déchets par l’usage de méthodes mixtes en sociologie : l’analyse du discours assistée par ordinateur et l’observation participante dans les usines chargées de l’élimination et de la valorisation des déchets. Elle vise à saisir le périmètre du travail dans le secteur du traitement et le contenu de l’activité du tri professionnel des déchets ménagers. En s’appuyant sur une sociologie de l’interaction, de la régulation sociale et du travail d’organisation, cette thèse montre les tensions qui existent entre la finalité environnementale de l’activité (emploi vert) et les conditions du travail industriel. La première partie souligne des éléments qui définissent ce type d’opposition. D’abord, nous avons observé une forte division du travail, notamment parce que la conception apparaît fort éloignée des activités manuelles qui s’exercent au sein des usines. Ensuite, la coexistence du secteur public et privé marque d’autres enjeux socio-économiques liés au type de gestion des activités. Enfin, travailler dans le milieu des déchets, c’est également prendre en compte la question des risques professionnels et pour l’environnement, qui ne recouvrent pas la même signification en fonction du contexte du travail. La seconde partie de la thèse vise à comprendre comment les travailleurs du tri vivent ces contradictions et comment ils arrivent à se mouvoir dans cet univers industriel contraignant. Cette thèse montre le passage du novice pour « devenir » un travailleur en intégrant un collectif et en s’appropriant le travail. Cela permet de souligner l’importance des relations sociales et de l’activité langagière dans ce milieu de travail a priori hostile aux interactions. Enfin, le poids des représentations du métier de trieur, le risque de souillure, et l’appréhension du travail à la chaîne amènent le travailleur à négocier ce très sale boulot pour le/se rendre plus viable et digne
This dissertation explores the work of waste management by the use sociological mixed methods: computer-assisted discourse analysis and participant observation in waste industries. This research aims at showing the scope of work in waste industry as well as the content of the professional household waste sorting activity. The research focuses on interaction, social regulation and organizational work. This PhD dissertation shows the tensions between environment (green jobs) and the conditions of industrial work. The first part emphasizes on the elements that define this type of opposition. We observed a strong division of labor, particularly because the conception appears very far from the actual manual activities occurring in factories. Then the coexistence of public and private showcase other socio-economic issues related to the type of management. Finally, work in the waste sector, it is also considering the issue of risks at work and environmental hazards, which meanings are subject to the work context. The second part of the dissertation research aims at understanding how the workers live these contradictions and how they manage to move in this constraining industrial world. The research shows the importance and the difficulties for a novice to "become" a worker through the integration of a work collective and the appropriation of work. This will highlight the importance of social relationships and language activity in a workplace “a priori” hostile to interactions. Finally, the weight of waste sorter job’s representations, the risk of soiling and the apprehension of line work bring the worker to negotiate this “very dirty work” in order to change the working conditions and representations to be more viable and decent

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3

Martins, Francine de Paulo. "A atividade docente com crianças de dois a três anos: do gênero ao estilo". Pontifícia Universidade Católica de São Paulo, 2009. https://tede2.pucsp.br/handle/handle/16573.

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The present research searched to investigate as it comes after being developed the teaching activity in a municipal school of infantile education twelve years of the promulgation of the LDBEN/96. For in such a way, the following questions of research had been proposals: How the organization of the school comes making possible the accomplishment of the teaching activity in the infantile education?; How does gender training is the teaching activities at this school?; How the teacher organizes and develops the teaching activity with children of two the three years? ; Which the challenges found for the teacher in the accomplishment of the teaching activity? They had been used as theoretical subsidy estimated of partner-historical Psychology and the categories real activity; Real of the activity; sort; e style proposals for Yves Clot in the Clinic of the Activity. They had been used as procedures and instruments of collection of data: comment and register; documentary analysis; interview; questionnaire application. After manipulation and preliminary analysis of the material, the data had been reorganized around the two great theoretical categories: Sort and Style. The results show that the forms of organization of the teaching activity in the EMEI Aprender, consider the curricular lines of direction formulated recently for the education secretariat, as well as the Theory of Multiple intelligences, referencial theoretician adopted in the year of 2009 for the teaching and managing team of the school. Such lapsings had significantly modified the carried through teaching activity in this EMEI. At the same time, it generated unreliability in the professors how much to the new form of performance. Different strategies had been formulated by the teachers to take care of or to not new lapsings them. In what it refers to the teaching activity in infantile the II, notices bigger valuation of the carried through didactic activities in classroom, mainly the manuals, conserving still present the escolarizante model in many schools of infantile education. In the external spaces, the activities that have predominance are the Free considered ones. Practical the pedagogical associates when playing and the exploration of the different spaces, understood as activities planned and loaded of intentions, sufficiently are reduced. To finish, she understands yourself that she enters the prescribed activity and the carried through work, has unsafe, changes of routes and differentiated forms of concretion of the lapsing that disclose the existing contradictions in the act of the work. In the situations where the prescribed imperfection, the teaching team of the EMEI Aprender searchs in the professional sort new possibilities of performance, reconfiguring it and recriando it by means of the personal style
A presente pesquisa teve por objetivo conhecer como vem sendo desenvolvida a atividade docente numa escola municipal de educação infantil, após doze anos da promulgação da LDBEN/96. Para tanto, foram propostas as seguintes perguntas de pesquisa: Como a organização da escola vem possibilitando a realização da atividade docente na educação infantil?; De que forma o gênero profissional constitui a atividade docente nessa escola? Como a professora organiza e desenvolve a atividade docente com crianças de dois a três anos?; Quais os desafios encontrados pela professora na realização da atividade docente? Foram utilizados como fundamentos teóricos a Psicologia sócio-histórica e a Clínica da Atividade de Yves Clot. Foram utilizados como procedimentos coleta de dados: observação, análise documental, entrevista e aplicação de questionário. Os dados foram organizados em torno das duas grandes categorias teóricas: Gênero e Estilo. Os resultados mostraram que as formas de organização da atividade docente na EMEI Aprender consideram as Diretrizes Curriculares formuladas recentemente pela Secretaria de Educação Municipal, bem como a Teoria das inteligências Múltiplas, referencial teórico adotado, no ano de 2009, pela equipe docente e gestora da escola. Tais prescrições modificaram significativamente a atividade docente realizada nessa EMEI. Ao mesmo tempo, geraram incertezas quanto à novas formas de atuação docente. Diferentes estratégias foram formuladas pelas professoras para atender as novas prescrições. No que tange à atividade docente no infantil II, nota-se maior valorização das atividades didáticas realizadas em sala de aula, principalmente as manuais, conservando o modelo escolarizante ainda presente em muitas escolas de educação infantil. Nos espaços externos, as atividades que têm predominância são as consideradas livres . As práticas pedagógicas associadas ao brincar e à exploração dos diferentes espaços, entendidas como atividades planejadas e carregadas de intenções não foram evidenciadas no período de observação.. Para finalizar, entende-se que entre a atividade prescrita e o trabalho realizado, há dúvidas, incertezas,, mudanças de rotas que revelam as contradições existentes no trabalho. Nas situações em que o prescrito falha, a equipe docente da EMEI Aprender busca no gênero profissional novas possibilidades de atuação, reconfigurando-o e recriando-o por meio do estilo pessoal

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Abreu, Miguel Cortês de. "O potencial bioativo do soro de queijo após fermentação lática. Comparação de diferentes tipos de soro". Master's thesis, ISA/UL, 2014. http://hdl.handle.net/10400.5/8307.

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Mestrado em Engenharia Alimentar - Qualidade e Segurança Alimentar - Instituto Superior de Agronomia
Cheese whey fermentation with lactic acid bacteria (LAB) results in the production of lactic acid, but can also induce the proteolysis of the major whey proteins, therefore originating polypeptides with antibacterial activities. This work set out to determine if by using different types of whey (ovine, caprine and bovine), inoculated with three different LAB strains, could enhance proteolysis degradation of major whey proteins and improve antibacterial activity. Lactic acid production was monitored throughout time by using chromatographic techniques and protein variations were evaluated by electrophoretic techniques. Low Molecular Weight (LMW) polypeptides were isolated by ultra filtration and tested for their bioactivities against the model bacteria Listeria monocytogenes. Overall, results showed that consumption of whey proteins α-lactalbumin and β-lactoglobulin as well as antibacterial activities induced by fermentation were highly dependent on the bacterial strain, the type of whey used and the length of fermentation. Despite being little known by its proteolytic activity towards caseins and whey proteins, Lactobacillus casei proved to be a strain with high fermentative potential and the capacity to produce antibacterial polypeptides

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5

Juan, Muriel. "Continuité de l’emploi et évolution des activités publiques". Thesis, Pau, 2012. http://www.theses.fr/2012PAUU2011/document.

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Phénomène classique en droit privé du travail, l’évolution d’une activité et le sort réservé aux salariés de droit privé qui y sont affectés figure parmi les thèmes fondamentaux du droit social contemporain, et fait, à ce titre, l’objet d’une jurisprudence relativement stabilisée et d’une littérature abondante. La problématique sociale des évolutions d’activités publiques, pour être tout aussi essentielle sinon plus que celle qui irrigue le secteur économique classique, souffre à l’inverse d’un manque d’analyse globale et approfondie, du moins de l’absence d’une mise en perspective de l’ensemble des hypothèses où elle est amenée à être soulevée. L’approche de la présente recherche est donc d’envisager la problématique sociale liée aux évolutions d’activités publiques dans sa globalité, en embrassant l’ensemble des hypothèses génériques concernées tant d’un point de vue organique – nature des personnels concernés comme nature des entités d’origine et d’accueil – que matériel – externalisation d’activités publiques, reprise en régie, décentralisation de compétences, transfert intercommunal de compétences, privatisation d’établissements publics, etc. L’ambition est ici de révéler le caractère primordial de la donnée sociale dans la conduite des évolutions d’organisation ou de gestion des activités publiques, et d’apporter, dans la démarche pratique qui est la nôtre, les clés essentielles à la résolution de la problématique sociale qu’elle peut engendrer, quelque soit l’hypothèse sur laquelle elle porte. Il s’agit, en premier lieu, en fonction de la nature publique et/ou privée des personnels concernés, d’identifier clairement les obligations de transfert des personnels de nature légales - d’ordre interne comme communautaire - ou conventionnelles, et de les confronter à la volonté politique de conserver ou réaffecter ces personnels. Il convient, en deuxième lieu, de préciser les modalités de transfert des personnels concernés. Il s’agit tout particulièrement de vérifier la nécessité d’obtenir un accord exprès de leur part, de formaliser le transfert par la signature par un contrat de travail ou encore de solliciter les institutions représentatives du personnel pour procéder au transfert effectif des agents. Il est, en troisième et dernier lieu, important d’envisager précisément les conséquences du transfert des personnels tant pour la structure d’accueil que pour les agents eux-mêmes, en termes financiers (niveau de rémunération, avantages individuels acquis, etc.) et opérationnels (organisation interne des ressources humaines, répartition des pouvoirs hiérarchiques entre structure d’origine et d’accueil pour les personnels mis à disposition, etc.)
Classical phenomenon in labour law, the changes which happens in an activity’s management or organisation and the resulting question of the employee’s fate appears like one of the most important contemporary labour law’s subject. Despite it concerns public undertakings engaged in economic activities, whether or not they are operating for gain, as well as private undertakings, this dimension is nevertheless well known and characterised by a lack of detailed analysis, at least by a putting in perspective’s lack of all hypothesis concerned. Consequently, this study chooses to consider the social issue following public activities changes in its globality by including all cases concerned, as well in an organic point of vue (employees nature, original structure or welcoming structure nature) then in a material point of vue (public activities externalization, return of an activity under a public control, decentralization, powers’ transfers between local authorities, privatization of public ownerships, etc.). This study’s aim is to reveal the importance of the human element in the event of a change on activity’s management or organisation and to give, in a practical view, the keys to resolve the social issue which belongs to each activity’s changes, whatever is the working hypothesis concerned. First, depending on the public or private nature of the personnel, it should be clearly identified the tranfer’s obligations which could exist according to labour legislation or a collective agreement and to bring them face to political decision to keep or redeploy employees. Then, it must be explained the procedure of transfer. More particularly, it should be confirmed if the transfer needs to be accepted by each employee, to be formalized by a contract signature or as well to be submitted to union companies. Finally, it is important to envisage precisely the transfer consequences as for employers then for employees, in financial (wages, individual or collective benefits, etc.) and operational terms (human resources organisation, management rules between original employer and new employer in case of provided civil servant, etc.)

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Jeong-Hun, Yi [Verfasser]. "Remodeling of soft tissues due to cell activity / Yi Jeong-Hun". Aachen : Hochschulbibliothek der Rheinisch-Westfälischen Technischen Hochschule Aachen, 2013. http://d-nb.info/1037838645/34.

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Codina, Sala Joan. "Activity Mediated Interactions in Soft Matter. Structure, Interactions, and Phase Transitions". Doctoral thesis, Universitat de Barcelona, 2018. http://hdl.handle.net/10803/663988.

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In this thesis we asses the phenomena of arising interactions in soft matter in coexistence with soft active matter. As a non-equilibrium bath we introduce ensembles of self-propelled particles, granular shaken beds, and photo active catalytic particles. We start the thesis with a detailed study of the widely used Active Brownian Particle (ABP) model. This model exhibits a non-equilibrium phase transition which has been intensively studied in recent years, we have finally reported that this transition satisfies all features of equilibrium first order phase transitions. Then, we introduce aligning interactions in ABP and characterize the emergent collective phenomena. In parallel, we explore the emergent forces, from mechanical contact forces, in probe particles in suspensions of aligning active particles and horizontally shaken granular beds. We characterize the forces and identify the emergence of long range interactions in both systems, in aligning active particles long range attractive interactions appear as alignment is increased, and in granular shaken media when the pair of particles align in the shaking direction. Finally, we conclude this thesis with the study of emergent interactions in spherically symmetric systems of catalytic active particles. Symmetry does not permit such particles to propell but the symmetry is broken with the addition of neighboring particles. We model the pair interaction in terms of the relative velocity between particles, and proceed to explore the emergent structures in mixtures of catalytic magnetic particles, and passive particles. We have unveiled the formation of clusters of passive particles. The addition of magnetic interactions between active particles leads to the formation of ramified gel-like structures for dense configurations of active particles. In this case, experimentalists have checked the formation of structures with the same morphologies in experiments in the laboratory.
En aquesta tesi abordem el fenomen de les interaccions emergents en matèria tova en coexistència amb matèria tova activa. Com a sistemes de matèria tova activa introduïm col·lectius de partícules autopropulsades, col·loides amb capacitat de catalitzar productes químics i medis granulars agitats. Primer de tot estudiem en detall un model molt estès per a partícules actives, el model de les partícules actives brownianes (ABP). D'aquest model estudiem amb detall una transició de fase de no equilibri i comprovem que la transició satisfà amb les característiques d'una transició en equilibri de primer ordre. Seguidament incorporem interaccions d'alineació en el model de partícules actives i procedim a estudiar les propietats col·lectives de les suspensions de partícules actives amb alineació. Per tal d'abordar l'objectiu de la tesi introduïm partícules de prova en suspensions de partícules actives, i en medis granulars amb forçament periòdic horitzontal, amb diferents paràmetres d'activitat per tal d'estudiar les forces, des d'un punt de vista mecànic, que emergeixen entre les parelles. Hem caracteritzat les forces i hem identificat l'aparició d'interaccions de llarg abast per sistemes de partícules amb alineació i en sistemes granulars en la direcció del forçament. Finalment, tanquem la tesi amb l'estudi i modelització d'interaccions emergents per a partícules catalítiques amb simetria esfèrica. La simetria no permet a les partícules d'autopropulsar-se però la presència de partícules al seu entorn sí que dóna lloc a interaccions, en forma de velocitats induïdes. Amb un model raonable de la interacció a distància hem calibrat la magnitud de la interacció amb sistemes experimentals i procedit a caracteritzar les estructures emergents per a mescles de partícules actives i passives que van des de la formació d'agregats en forma de clústers. L'addició d'interaccions magnètiques entre partícules actives permet la formació d'estructures ramificades de tipus gel. En aquest cas l'equip experimental ha pogut comparar l'aparició d'estructures amb les mateixes característiques al laboratori.

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Araújo, Francielly Negreiros de. "Avaliação do perfil proteico e atividade biológica do soro de colostro caprino". Universidade Federal da Paraíba, 2017. http://tede.biblioteca.ufpb.br:8080/handle/tede/9392.

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Colostrum from the first secretions of the mammary glands is considered an essential food for the development of newborns due to its high content of proteins, antimicrobial peptides, macro and micronutrients. The serum is considered na important coproduct for the dairy industry, configuring about 85-90% of the total milk volume, its proteins are recognized by their biological properties, since they have an excellent composition and bioavailability of essential amino acids. The present study had as objective to characterize the serum protein profile of goat colostrum produced by goats Created in Paraíba and to evaluate possible biological activities. The serum (SR) was obtained by acid precipitation in pH 4.1 and fractionated by ammonium sulfate precipitation to obtain the fractions 0-30% (SF1), 30- 60% (SF2) and 60-90% (SF3). The analysis of the protein profile was verified by SDS-PAGE and total amino acids. The biological properties of the samples were verified with the analysis of antioxidant, DNA protection and antibacterial activities. It was verified that colostrum serum presents proteins with molecular masses between 12-160kDa and an excellent profile of amino acids. From the obtained results it is possible to affirm that all the fractions were able to sequester the radicals ABTS and DPPH. For the DNA protection test, the concentracion of 10μg of SF3 conferred a greater integrity to the molecule. The samples presented inhibitory activity for both gram-negative and gram-positive bacteria. Colostrum serum proteins have biological properties with potential biotechnological application and pharmaceutical interest
O colostro oriundo das primeiras secreções das glândulas mamárias é considerado um alimento essencial para o desenvolvimento dos recém-nascidos, devido seu elevado teor de proteínas, peptídeos antimicrobianos, macro e micronutrientes. O soro é considerado um coproduto importante para a indústria leiteira, configurando cerca de 85–90% do volume total do leite. Suas proteínas são reconhecidas pelas propriedades biológicas, uma vez que possuem uma excelente composição e biodisponibilidade de aminoácidos essenciais. O presente estudo teve como objetivo caracterizar o perfil proteico do soro de colostro caprino produzido por cabras criadas na Paraíba e avaliar possíveis atividades biológicas. O soro (SR) foi obtido por precipitação ácida em pH 4,1 e fracionado por precipitação com sulfato de amônio para obtenção das frações 0-30% (SF1), 30-60% (SF2) e 60-90% (SF3). A análise do perfil proteico foi verificado por SDS-PAGE e aminoácidos totais. As propriedades biológicas das amostras foram verificadas com as análises das atividades antioxidante, proteção ao DNA e antibacteriana. Verificou-se que o soro do colostro apresenta proteínas com massas moleculares entre 12-160kDa e um excelente perfil de aminoácidos. A partir dos resultados obtidos é possível afirmar que todas as frações foram capazes de sequestrar os radicais ABTS e DPPH. Para o teste de proteção ao DNA, a concentração de 10μg de SF3 conferiu uma maior integridade à molécula. As amostras apresentaram atividade inibitória tanto para as bactérias gramnegativas quanto para gram-positivas. As proteínas do soro do colostro apresentam propriedades biológicas com potencial aplicação biotecnológica e de interesse farmacêutico.

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Brandt, William Nielsen. "Aspects of soft X-ray activity in the centres of radio-quiet active galaxies". Thesis, University of Cambridge, 1995. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.242938.

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James, Rebecca E. "Crimpy Sorts a BMP into the Regulated Secretory Pathway for Activity-Dependent Release in Drosophila Motorneurons". Case Western Reserve University School of Graduate Studies / OhioLINK, 2013. http://rave.ohiolink.edu/etdc/view?acc_num=case1364994680.

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Saraiva, Catarina Ribeiro. "VLE and activity coefficients of ionic liquids + water systems". Master's thesis, Universidade de Aveiro, 2014. http://hdl.handle.net/10773/14508.

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Mestrado em Engenharia Química
The industrial progress is a phenomenon more and more present worldwide, where it is possible to observe an increasing demand for innovation, which therefore results in competitiveness and growth. A consequence of this innovation is the discovery of a novel type of compounds such as: the ionic liquids. These have attracted a high interest in the recent years due to its characteristics, namely: low vapour pressure, good thermal stability, etc. This new class of compounds has a large range of applications, for instance in cooling absorption. The industrial application of ionic liquids (ILs) requires the knowledge of their termophysical properties, their phase behaviour and of their mixtures. This work addresses the study of those thermodynamic properties of water + ionic liquids systems using the state equation soft-SAFT EoS, the ILs under study are: 1-butyl-3-methyli midazolium trifluoromethanesulfunate, 1-butyl-3-methylimidazolium tosylate, 1-butyl-3-methylimidazolium trifluoroacetate, 1-butyl-3-ethylimidazolium methanesulfunate, 1-butyl-3-methylimidazolium bromide, 1-butyl-3-methylimidazolium chloride and 1-butyl-3-methylimidazolium thiocyanate. This work also addresses the description of water activities in ionic liquids. The study began by starting to define the appropriate association scheme of each ionic liquid, then molecular parameters for each compound were regressed using density data at atmospheric pressure, always trying to find the parameter set with the lowest error in the density description. Then it was initiated the vapour-liquid equilibria study of binary systems composed by water + ionic liquid, this study was made for seven mixtures, composed by the ILs previous mentioned and for three different pressure values, namely : 0.1 MPa, 0.07 MPa and 0.05 MPa. Finally, it was started the water activities coefficients study, of the seven systems in order to select the best pair water + IL that best satisfies the application referred above.
A evolução industrial é um fenómeno cada vez mais presente a nível mundial, onde se observa uma elevada procura pela inovação, que se traduz em competitividade e em crescimento. Uma consequência desta inovação está relacionada com a descoberta de um novo tipo de compostos: os líquidos iónicos. Estes têm despertado um elevado interesse nos últimos anos devido às suas características, nomeadamente, baixa pressão de vapor, boa estabilidade térmica etc. Esta nova classe de compostos tem uma vasta gama de aplicações, como por exemplo na área de absorventes para refrigeração. A aplicação industrial dos líquidos iónicos requer o conhecimento das suas propriedades termofísicas e do comportamento do seu equilíbrio de fases. Este trabalho foca-se, pela primeira vez, no estudo dessas propriedades termodinâmicas de sistemas líquidos iónicos (ILs) + água com a equação de estado soft-SAFT (Statistical Associating Fluid Theory). Os ILs em estudo são: trifluorometanosulfonato de 1-butil-3-metilimidazólio, tiocianato de 1-butil-3-metilimidazólio, trifluoroacetato de 1-butil-3-metilimidazólio, metanosulfanato de 1-butil-3-metilimidazólio, cloreto de 1-butil-3-metilimidazólio, brometo de 1-butil-3-metilimidazólio e tiocianato de 1-butil-3-metilimidazólio. Neste estudo começou-se por definir esquemas associativos apropriados para cada um dos líquidos iónicos, de seguida com base nos esquemas atribuídos e utilizando dados de densidade à pressão atmosférica otimizaram-se os parâmetros moleculares característicos a cada composto, com o menor erro possível na descrição da densidade. De seguida passou-se ao estudo do equilíbrio líquido-vapor de sistemas binários compostos por água + líquido iónico, este estudo foi efetuado para sete misturas, compostas pelos ILs anteriormente apresentados e para 3 valores de pressão distintos, nomeadamente: 0.01 MPa, 0.07 MPa e 0.05 MPa. Por fim, passou-se ao estudo dos coeficientes de atividade da água de cada uma das misturas de forma a selecionar o sistema água + IL que melhor satisfaça as exigências da aplicação inicialmente referida.

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12

Farr, Joshua Nicholas. "Influences of Soft Tissue Composition and Physical Activity on Bone Volumetric Density, Bone Geometry, and Fracture Prevalence in Young Girls". Diss., The University of Arizona, 2011. http://hdl.handle.net/10150/145283.

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Fractures are a major public health concern and there is an urgent need to identify high-risk individuals. This study used novel approaches in bone imaging to characterize optimal skeletal development in girls and enhance our understanding of the structural and functional deficits that contribute to skeletal fragility and fracture risk during growth. The findings indicate that fracture in girls is associated with lower trabecular bone density, but not bone macro-architecture at metaphyseal regions of weight-bearing bones, which is consistent with findings reported in children at the distal radius. These findings suggest that lower trabecular density at metaphyseal regions of long bones track throughout the appendicular skeleton and may be an early marker of skeletal fragility.Obese children are overrepresented in childhood fracture cases. Nevertheless, the effects of fat on bone during growth remain unclear. This study showed that skeletal muscle was a stronger determinant of bone parameters in girls than total body adiposity, although fat mass had a persistent, albeit weak association with bone parameters. Furthermore, fatty infiltration of skeletal muscle, which is associated with type 2 diabetes mellitus, was inversely associated with bone strength in girls. These findings are consistent with the proposed functional model of bone development which posits that forces from muscle contractions are the main mechanical challenges to which bones adapt.Physical activity during growth is critical for optimal bone development. The findings from this study support this premise and suggest that regular physical activity enhances bone strength in girls. Nevertheless, for exercise to be accepted as an important public health osteoporosis prevention strategy, lasting adaptations must be shown. Plausible biological explanations have been offered in support of the peri-pubertal years as a "window of opportunity" for maximizing the response to exercise. Findings from this study suggest that a two year school-based high-impact jumping intervention was not an effective means to enhance bone parameters in girls. Controlled dose-response trials will be necessary to test questions regarding the types, bouts, and durations of exercise required to define the "dose" of exercise needed to elicit meaningful skeletal adaptations during growth.

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13

Hindle, Giles Anthony. "Developing a systemic textual analysis method based on the human activity system modelling language of soft systems methodology". Thesis, University of Lincoln, 2003. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.400869.

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14

McCord, Olivia Love. "Body Mass Index and Soft Drink Consumption Among Adolescents". Diss., CLICK HERE for online access, 2004. http://contentdm.lib.byu.edu/ETD/image/etd475.pdf.

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15

Carew, Jennifer S., Claudia M. Espitia, Weiguo Zhao, Monica M. Mita, Alain C. Mita y Steffan T. Nawrocki. "Oncolytic reovirus inhibits angiogenesis through induction of CXCL10/IP-10 and abrogation of HIF activity in soft tissue sarcomas". IMPACT JOURNALS LLC, 2017. http://hdl.handle.net/10150/625966.

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The tumor-selective viral replication capacity and pro-apoptotic effects of oncolytic reovirus have been reported to be dependent on the presence of an activated RAS pathway in several solid tumor types. However, the mechanisms of selective anticancer efficacy of the reovirus-based formulation for cancer therapy (Reolysin, pelareorep) have not been rigorously studied in soft tissue sarcomas (STS). Here we report that Reolysin triggered a striking induction of the anti-angiogenic chemokine interferon-gamma-inducible protein 10 (IP-10)/CXCL10 (CXC chemokine ligand 10) in both wild type and RAS mutant STS cells. Further analysis determined that Reolysin treatment possessed significant anti-angiogenic activity irrespective of RAS status. In addition to CXCL10 induction, Reolysin dramatically downregulated the expression of hypoxia inducible factor (HIF)-1 alpha, HIF-2 alpha and inhibited vascular endothelial growth factor (VEGF) secretion. CXCL10 antagonism significantly diminished the anti-angiogenic effects of Reolysin indicating that it is a key driver of this phenomenon. Xenograft studies demonstrated that Reolysin significantly improved the anticancer activity of the anti-angiogenic agents sunitinib, temsirolimus, and bevacizumab in a manner that was associated with increased CXCL10 levels. This effect was most pronounced following treatment with Reolysin in combination with temsirolimus. Further analysis in additional sarcoma xenograft models confirmed the significant increase in CXCL10 and increased anticancer activity of this combination. Our collective results demonstrate that Reolysin possesses CXCL10-driven anti-angiogenic activity in sarcoma models, which can be harnessed to enhance the anticancer activity of temsirolimus and other agents that target the tumor vasculature.

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16

Gálvez, Mesina Claudia Verónica. "El BDS como estrategia política de soft power". Tesis, Universidad de Chile, 2017. http://repositorio.uchile.cl/handle/2250/147228.

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Tesis para obtener el grado de Magíster en Estudios Internacionales
El movimiento ciudadano internacional Boicot, Desinversiones y Sanciones Contra Israel – BDS surge como respuesta frente a la persistente pasividad de la comunidad internacional respecto de la insostenible y desastrosa situación que vive el pueblo palestino ya sea en el exilio o bajo la discriminación, segregación y represión institucional, una realidad que se ha mantenido así por siete décadas. Los tres únicos objetivos de su campaña están basados en el Derecho Internacional y en resoluciones de Naciones Unidas, resoluciones que hasta la fecha no han sido cumplidas por el Estado Israelí. Se trata de una forma de lucha no violenta cuya estrategia de desinversión y boicot económico, académico y cultural a empresas e instituciones vinculadas a la ocupación han generado la presión suficiente para provocar cambios en la política exterior israelí, presentando una nueva imagen al exterior. La presente investigación tiene por objeto analizar el poder de atracción o Soft Power del BDS y su capacidad de empujar al Estado Israelí hacia la reconfiguración de su propaganda política o “hasbara” la cual constituye el núcleo de su diplomacia pública.
The Boycott, Divestments and Sanctions Against Israel campaign or BDS is an international social movement which emerges as a response to the international community’s persistent lack of determination regarding the unsustainable and devastating situation of the Palestinian people, who are living either in exile or under discrimination, segregation and institutional repression, situation they have been going through for seven decades. The three objectives of the BDS campaign are based on international law and on United Nations resolutions which, to date, have not been met by the Israeli State. BDS is a non-violent struggle whose divestment strategy and economic, academic and cultural boycott of companies and institutions linked to the Israeli occupation have produced enough pressure to make Israel change its foreign policy introducing a whole new image abroad. The purpose of this research is to analyze the power of attraction or Soft Power of the BDS and its ability to push the Israeli State towards the reconfiguration of its political propaganda or "hasbara" which constitutes the core of its public diplomacy.
2018.01.01

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17

Hamidi, Ali. "Influence of soft materials on student engagement with STEM : Combination of technology, programming, and textiles in a maker movement activity". Thesis, Linnéuniversitetet, Institutionen för informatik (IK), 2018. http://urn.kb.se/resolve?urn=urn:nbn:se:lnu:diva-79295.

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While the computer programing becomes a fundamental skill in the last century, it has been globally acknowledged that there is a decline in number of graduates in disciplines of Science, Technology, Engineering and Mathematics (STEM). Many scholars have been addressing this lack of interest and studied student engagement with STEM through variety of engagement programs and activities. In this master thesis as an exploratory qualitative study, technology and programing are blended together in a workshop hosting students of age 12-13 towards the development of their enthusiasm and engagement with STEM. During the activity, students used Makey Makey toolkit and Scartch programming language by application of textiles as soft material to investigate how this combination impact the engagement, and in what ways soft materials influence it. The study results in the light of Flow theory showed that four attributes of attention, motivation, engagement and social interaction pursued in the workshop. Textiles, as a mediator by expanding the flow state boundaries make the activity softer to encourage students being engaged in it, particularly from a gender perspective.

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18

Zaffani, Viviane Costa Silva. "Avaliação do metabolismo proteico muscular de ratos alimentados com proteinas do soro do leite e submetidos a atividade fisica". [s.n.], 2009. http://repositorio.unicamp.br/jspui/handle/REPOSIP/254470.

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Orientador: Jaime Amaya-Farfan
Dissertação (mestrado) - Universidade Estadual de Campinas, Faculdade de Engenharia de Alimentos
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Resumo: A ocorrência de desvios no metabolismo protéico durante o exercício depende tanto da intensidade, duração e freqüência do exercício, como também da ingestão alimentar, especialmente da qualidade da dieta consumida. Neste contexto, proteína do soro do leite (PSL) destaca-se pelo seu alto valor nutritivo, devido tanto à composição de aminoácidos, quanto à rápida digestão, além de outras funcionalidades relacionadas com a saúde. O objetivo deste estudo foi avaliar em ratos os efeitos da ingestão da proteína do soro do leite, na sua forma intacta e hidrolisada (~12,5% de hidrólise), em associação à atividade física de endurance, sobre os níveis séricos de aminoácidos, evolução ponderal, conteúdo protéico em gastrocnêmio e sóleo, conteúdo de DNA no gastrocnêmio, níveis séricos de IGF1, síntese e degradação protéica no grastrocnêmio e síntese no sóleo. Ratos Wistar foram distribuídos em 6 grupos, de acordo com a proteína consumida (12%): caseína (CAS), isolado protéico do soro do leite (IPSL) ou hidrolisado protéico do soro do leite (HPSL)) e submetidos a um protocolo de atividade física (sedentários (S) e treinados (T)). Os ratos treinados correram em esteira, durante 9 semanas, e foram sacrificados após 48 horas de repouso e 12 horas de jejum. As três dietas utilizadas apresentaram conteúdos semelhantes de aminoácidos totais, mas as dietas IPSL e HPSL destacaram-se apresentando maiores valores absolutos de leucina, isoleucina, lisina, treonina, cistina, alanina e ácido aspártico, em relação a CAS. No geral, os níveis séricos de aminoácidos indispensáveis foram semelhantes para os grupos IS e HS, em comparação com os ratos controle sedentários (CS), enquanto o grupo HT apresentou o maior nível destes aminoácidos, em relação ao CT. A evolução ponderal foi semelhante para todos os grupos de ratos até o final da oitava semana de treinamento. Na nona semana, os grupos treinados apresentaram peso significativamente menor que o CS. Não houve diferença estatística para o peso, conteúdo protéico dos músculos gastrocnêmio e sóleo, níveis séricos de IGF1 e taxas de degradação protéica muscular do gastrocnêmio, entre todos os grupos experimentais. O conteúdo e concentração de DNA no gastrocnêmio foi significativamente menor em ambos os grupos que consumiam a HPSL (HS e HT), independente da atividade física, comparado aos grupos que consumiam as proteínas intactas (CS, IS, CT e IT). As taxas de síntese protéica nos músculos gastrocnêmio e sóleo também foram menores para o grupo HT, comparado aos sedentários (CS, IS e HS), mas sem mostrar diferença com os grupos CT e IT. Os ratos do grupo HT destacaram-se por apresentar diminuição da demanda por nova síntese protéica, e da necessidade de utilização de aminoácidos do pool sérico diminuindo, consequentemente, a necessidade de aumentar a quantidade de DNA celular no músculo gastrocnêmio e ainda assim, manteve o peso, a concentração e o conteúdo protéico muscular sem diferença em relação aos demais grupos. Estes resultados, considerados em conjunto, sugerem que o consumo da proteína hidrolisada do soro do leite pode contribuir para a preservação da massa muscular no gastrocnêmio, quando associado à atividade física de endurance.
Abstract: Physical exercise promotes protein metabolic alterations depending not only on its intensity, duration and frequency, but also on food intake and especially on the quality of the diet. In this context, the milk whey proteins (PSL) stand out because of their high quality, meeting both amino-acid profile and digestibility requirements, besides other functional properties. The aim of this study was to assess the effects of milk whey protein intake in rats, in both the intact and hydrolyzed forms (~12,5% of hydrolysis), associated with physical activity of endurance, on serum amino acids levels, body weight, protein content in both the gastrocnemius and soleus muscles, total DNA content in the gastrocnemius, serum IGF1 levels, protein degradation rate in the gastrocnemius, and of protein synthesis in the soleus and gastrocnemius. Male Wistar rats were divided into six groups as follows: protein consumed (12%), casein - CAS, milk whey protein isolate - IPSL, or milk whey protein hydrolyzate -HPSL) and physical activity protocol (sedentary, S, and trained, T). The trained rats were exercised on the treadmill during nine weeks and sacrificed following 48 hours of rest; the last 12 hours being fasted. The three diets tested produced similar contents of total amino acids, although the IPSL and HPSL diets stood out because of the higher absolute values of leucine, isoleucine, lysine, threonine, cysteine, alanine and aspartate than those of CAS. As a whole, the serum indispensable amino acid levels were similar when comparing both IS and HS groups with the control group (CS). However, the HT group showed higher levels of these amino acids than the CT group. No difference in body weight evolution was apparent among the groups until the end of the eighth week of training. Nevertheless, on the ninth week the trained groups showed significantly lower weights than group CS. There were no significant differences, among all groups studied, in the weight, the content and concentration of both gastrocnemius and soleus muscles, and serum IGF1 levels, as well as the degradation rate of proteins in the gastrocnemius muscle. The content and concentration of DNA in the gastrocnemius were significantly lower in both groups fed HPSL (HS and HT), regardless of physical activity, than in the groups fed intact protein (CS, IS, CT and IT). The rate of protein synthesis in both gastrocnemius and soleus muscles were also lower in the HT group than those found in the CS, IS and HS groups. However, there was no difference when compared to those of the IT and CT groups. Summarizing, the HT group stood out because of its lower demand for new protein synthesis and amino acid utilization from the serum pool, consequently decreasing the need for higher amount of cellular DNA in the gastrocnemius muscle. Even so, this group kept the same muscle mass, protein content and concentration, as those of the other groups. These results suggest that the consumption of hydrolyzed milk whey protein may contribute to the preservation of the gastrocnemius muscle when associated with physical activity of endurance.
Mestrado
Nutrição Experimental e Aplicada à Tecnologia de Alimentos
Mestre em Alimentos e Nutrição

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19

Senol, Aylin. "Understanding The New Activism Of Turkey In The Middle East: Turkey As An Emerging Soft Power". Master's thesis, METU, 2011. http://etd.lib.metu.edu.tr/upload/12612755/index.pdf.

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This thesis will examine the transformation in the Turkish foreign policy towards the Middle East and evaluate the relevance of &ldquo
soft power&rdquo
term for describing Turkey&rsquo
s new activism in the region. Since the establishment of the Turkish Republic, Turkey has aligned itself with the Western world so that this alignment has been the main determinant of its relations with the non-Western world. The Middle East was not an exception in this process. After decades of remaining aloof from the Middle Eastern affairs, Turkey has followed a new foreign policy towards the region, as part of its new foreign policy vision, since the AK Party coming to power in 2002 and has shown a growing willingness to participate in Middle Eastern affairs. Various arguments are developed by different actors, including the one elaborated in this thesis, to explain the new activism of Turkey in the region.

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20

Soliani, Fernanda Miriane Bruni. "Avaliação da neutralização de importantes atividades tóxicas induzidas pelos principais peixes peçonhentos brasileiros por um soro poliespecífico produzido em murinos". Universidade de São Paulo, 2008. http://www.teses.usp.br/teses/disponiveis/42/42133/tde-25032009-155737/.

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No Brasil acidentes por peixes peçonhentos como Thalassophryne nattereri, Cathorops spixii, Scorpaena plumieri e Potamotrygon gr orbygnyi vêm sendo relatados. O quadro clínico é caracterizado por efeitos locais e sistêmicos. Para esses acidentes não existe tratamento adequado e eficiente. A soroterapia é um eficiente tratamento para reverter os efeitos causados por venenos. Diante disso nosso objetivo é a obtenção de um soro poliespecifico através da junção de soros monoespecificos produzidos em camundongos e avaliar a sua capacidade de neutralização das atividades tóxicas induzidas pelos principais peixes peçonhentos brasileiros. As alterações induzidas na microcirculação foram abolidas na pré-incubação e no tratamento imediato, somente dano em fibra muscular induzido pelo C. spixii exigiu soro na proporção 1:2. Obtivemos o controle parcial da nocicepção e edema. O efeito sistêmico foi eficientemente neutralizado. Nossos dados nos permitem sugerir o uso de soro poliespecífico nos envenenamentos causados pelos peixes T. nattereri, S. plumieri, C. spixii e P. gr orbygnyi.
Envenoming induced by venomous fish represents a great cost brazilian communities. Victims develop local and systemic symptoms. The most frequent founded are Thalassophryne nattereri, Cathorops spixii, Scorpaena plumieri and Potamotrygon gr orbygnyi. The anti-inflammatory drugs used are not efficient. After the accident, the passive transfer of heterologous specific antibodies allows that immediate toxic effect can be neutralized in the victims. The aim of this work was to produce in mice polyspecific antivenom and evaluation the neutralization of the main toxic effects induced by the brazilian venomous fish. The effects induced in microcirculation were abolished by the polyspecific antiserum, except for the effects caused by C. spixii in muscular fibers where was necessary a proportion of 1:2. The polyspecific antiserum controlled the edematogenic and nociceptive activities and the airway inflammation.These data allow us to suggest the use of polyspecific antiserum in the treatment of the pathological effects provoked by the most frequent brazilian venomous fish.

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21

Leclerc, Charles-Olivier. "Les facteurs associés à la sexualité précoce chez les jeunes qui présentent des problèmes de conduites ou qui sont à risque d'en présenter". Mémoire, Université de Sherbrooke, 2016. http://hdl.handle.net/11143/9721.

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Les jeunes ayant des problèmes de conduites (PC) sont à risque d'avoir des conséquences développementales majeures tout au long de leur vie. Ces conséquences entraînent d'importants coûts autant pour eux que pour la société. Parmi celles-ci, il y a la sexualité précoce, qui doit faire l'objet d'études auprès des jeunes présentant des PC puisqu’elle augmente le risque de contracter une maladie transmise sexuellement, de vivre une grossesse non désirée chez les filles ou de la parentalité précoce chez ces jeunes en général. Selon la théorie développementale de Moffitt (1993), les jeunes, dont les conduites antisociales débutent avant 10 ans et qui persistent jusqu'à l'âge adulte, sont les plus à risque de sexualité précoce. Chez ces jeunes, il serait possible de prédire la sexualité précoce en se basant sur trois domaines de facteurs de risque : les conditions sociofamiliales adverses et les pratiques parentales inadéquates, le comportement de l'enfant et son tempérament, ainsi que le développement neurocognitif (Moffitt et Caspi, 2001). Dans la documentation scientifique, certains auteurs ont montré que des facteurs de risque de ces domaines étaient associés à la sexualité précoce. Néanmoins, plusieurs facteurs (p.ex. : la précocité des PC ou les facteurs du développement neurocognitif) demeurent à explorer. Le présent mémoire a pour objectif d'examiner le poids relatif de différents facteurs associés au risque de sexualité précoce chez les jeunes présentant des PC ou à risque d'en présenter. De plus, afin de vérifier si les mêmes facteurs sont associés à la sexualité précoce pour les filles et les garçons, les interactions entre les facteurs associés à la sexualité précoce et le sexe ont été explorées. Provenant d'une étude longitudinale d'envergure, l'échantillon est composé de 143 jeunes qui présentaient ou non des PC au début du projet. Les résultats suggèrent que cinq variables sont associées à une augmentation du risque de sexualité précoce, soit 1- la perception de comportements de rejets indifférenciés du parent envers son enfant, 2- l'affiliation du jeune à des pairs déviants, 3- la précocité des symptômes de PC,4- le fait d’être une fille ou 5- le fait d’être un garçon et de présenter des PC précoces. De leur côté, les habiletés verbales (fluidité) diminuent le risque de sexualité précoce chez les jeunes présentant des PC ou à risque d'en présenter. Ces différents constats militent en faveur d'adapter certains programmes de prévention des conduites antisociales persistantes en y ajoutant des modules sur la sexualité. Chez les jeunes qui présentent l'ensemble de ces facteurs de risque, il serait important d'éduquer les jeunes sur la sexualité afin d'éviter que ces jeunes aient d'autres activités sexuelles à risque. Par ailleurs, il serait souhaitable d’étudier d’autres variables susceptibles d’être associées à la sexualité précoce (par ex. : l'intelligence ou la réussite en lecture). De plus, ce domaine de recherche nécessite d'autres travaux afin d'évaluer si les facteurs associés à la sexualité précoce sont également liés à d'autres activités sexuelles à risque comme l'utilisation inconstante de contraception.

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22

Nery-Diez, Ana Cláudia Coelho 1980. "Efeito do consumo de proteina do soro do leite bovino, parcialmente hidrolisada e da atividade fisica em proteases intestinais do rato". [s.n.], 2007. http://repositorio.unicamp.br/jspui/handle/REPOSIP/254488.

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Orientador: Jaime Amaya-Farfan
Dissertação (mestrado) - Universidade Estadual de Campinas, Faculdade de Engenharia de Alimentos
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Resumo: As proteínas do soro do leite apresentam propriedades fisiológicas, funcionais e nutricionais diferentes que resultam na modulação ou melhoramento de funções bioquímicas e fisiológicas, aumentando a resistência e protegendo o organismo contra infecções ou retardando certos processos patológicos, assim como melhorando o desempenho físico. Estudos têm demonstrado melhoras em parâmetros bioquímicos e físicos proporcionados por estas proteínas. Assim, considerou-se de interesse investigar algumas das possíveis alterações ou efeitos fisiológicos, provocados pela ingestão de fonte protéica de alto peso molecular (isolado do soro do leite) e um hidrolisado enzimático dessa proteína. Além disso, levou-se em consideração o efeito da atividade física em ratos treinados em esteira, na atividade catalítica de proteases intestinais como: glutaminase, leucina-aminopeptidase, quimotripsina e tripsina e verificou-se também a possível absorção de peptídeos que constituem o hidrolisado, no intestino delgado. Na análise das atividades enzimáticas observou-se que o consumo da proteína hidrolisada promoveu diminuição da atividade da enzima glutaminase intestinal de 25 a 29%, em relação à atividade produzida pelas proteínas intactas (isolado e caseína). O treinamento, porém, teve como efeito aumentar a atividade glutaminase entre 27 e 32% para cada uma das dietas, exceto para o hidrolisado, que permaneceu sem alteração. A exaustão, por outro lado, resultou em diminuição da atividade glutaminase intestinal para quase todas as dietas (média aproximada de 30%). Na avaliação das enzimas presentes no lúmen intestinal, as atividades das três proteases, leucina-aminopeptidase, quimotripsina e tripsina, foram encontradas mais elevadas na fração do jejuno, em comparação ao íleo. Foi observada uma aparente inibição enzimática da tripsina na fração jejunal pela presença de caseína. Para verificar a possibilidade de absorção de peptídeos inteiros, foi realizada uma análise in vitro com os intestinos delgados. O intestino fresco extraído foi infundido com uma suspensão de cada proteína e incubado em solução fisiológica por duas horas, na temperatura de 37°C. Após, tal procedimento, os perfis de aminoácidos e de peptídeos perfusados foram obtidos por métodos cromatográficos e eletroforéticos. Neste estudo, pode-se constatar que houve maior passagem de aminoácidos nos intestinos delgados dos grupos sedentários-exaustos e treinados, que foram infundidos com o hidrolisado e nos grupos sedentários e treinados, que foram infundidos com isolado. Em relação aos diferentes níveis de atividade física, os animais treinados, alimentados com ambas as dietas, isolado e seu proteolisado, tiveram maior passagem de aminoácidos. Conclui-se que o consumo da proteína parcialmente hidrolisada não afetou de igual forma a atividade das três proteases, tripsina, quimotripsina e leucina-aminoeptidase, sendo que o treinamento e o hidrolisado, conjuntamente, redundaram em diminuição da atividade da quimotripsina, enquanto que a atividade da glutaminase foi visivelmente diminuída pela combinação da exaustão e o consumo do hidrolisado. Por sua vez, foi possível evidenciar a passagem de peptídeos do hidrolisado, do interior, para o exterior do jejuno perfusado do rato
Abstract: The whey protein offers various physiological, functional and nutritional properties that result in the modulation or improvement of physiological and biochemical functions, thus protecting the body against infections and delaying the onset of certain pathological processes, as well as improving the physical performance. Researchers have attributed to these proteins benefits such as the improvement of biochemical and physical parameters of the exercising animal. Therefore, it was considered of interest investigate some of the possible alterations resulting from the ingestion of the milk whey proteins (whey protein isolate) as the only source of high-molecular weight protein, as compared to an intermediate-degree enzymatic hydrolyzate of this protein and the casein standard. Moreover, the effect of the physical activity on the catalytic activity of the intestinal proteases glutaminase, leucine-aminopeptidase, chymotrypsin and trypsin, of rats trained in the treadmill was taken as an additional variable. Moreover, the possible absorption of constituent peptides of the hydrolyzate from the small intestine was investigated. In the analysis of the enzymatic activities it was observed that the consumption of the hydrolyzed protein prompted a reduction of the activity of the intestinal enzyme glutaminase by 25 to 29%, in relation to the activity produced by the unbroken proteins (isolate and casein). Physical training, however, had the effect of increasing the activity of glutaminase between 27 and 32% for each one of the diets, except for the hydrolyzate, which remained unaltered. Exhaustion, on the other hand, resulted in the reduction of the intestinal activity glutaminase for most of the diets (mean of ~30%). Assessment of the enzymes present in the intestinal lumen, the activities of three proteases, leucine-aminopeptidase, chymotrypsin and trypsin, were higher in the jejunal fraction, in comparison to the ileum. An apparent enzymatic inhibition of trypsin occurred in the jejunal fraction in the presence of casein. In order to verify the possibility of absorption of whole peptides, fresh intestinal fractions were infused with suspensions of each protein and incubated in physiological solution for two hours, at 37°C. After, such process the amino acid and peptide profiles were determined by chromatographic procedures. It was observed that a greater outflow amino acids occurred in the intestines sedentary-exhaust and trained group that were infused with the hydrolyzate, and in the sedentary and trained group that were infused with whey protein isolate. With regard to the effect of the different levels of physical activity, the animals that underwent training, fed with either of the diets, isolate or its hydrolyzate, had greater amino acid outflow than the sedentary animals. It is concluded that consumption of the hydrolyzate did not affect equally the activity of the three proteases, trypsin, chymotrypsin and leucine-aminopeptidase, noticing that a combination between training and the hydrolyzate caused a decrease of the activity of chymotrypsin, whereas the activity of glutaminase was clearly diminished by a combination between exhaustion and consumption of the hydrolyzate. Evidence has been presented showing that infusion of the hydrolyzate into the small intestine of the rat results in the passage of peptides from the interior to the exterior of the intestinal wall
Mestrado
Nutrição Experimental e Aplicada à Tecnologia de Alimentos
Mestre em Alimentos e Nutrição

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23

Abecia-Soria, Maria Ines. "Efeitos metabolicos induzidos pelo consumo de dietas com caseina (padrão) e proteinas de soro de leite bovino (isolado e hidrolisado) usadas como unica fonte proteica em ratos (wistar) submetidos a treinamento fisico em esteira". [s.n.], 2010. http://repositorio.unicamp.br/jspui/handle/REPOSIP/256023.

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Orientador: Celio Kenji Miyasaka
Tese (doutorado) - Universidade Estadual de Campinas, Faculdade de Engenharia de Alimentos
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Resumo: As proteínas do soro de leite são consideradas de alto valor nutritivo. Elas têm escore químico superior às de outras proteínas de origem animal, possuem elevadas concentrações de aminoácidos de cadeia ramificada (BCAA), com excelente balanço e biodisponibilidade de aminoácidos essenciais. As proteínas de soro de leite vêm sendo largamente utilizadas pela indústria de alimentos como suplemento na alimentação de esportistas, devido às suas características fisiológicas e funcionais, destacando-se o uso dos hidrolisados, que tem sido recomendado para situações de estresse metabólico como o exercício físico em que a reposição de proteínas no organismo se torna necessária. O presente trabalho teve como objetivo avaliar alterações metabólicas induzidas pelo consumo de proteínas do soro de leite [isolado (ISL) e seu hidrolisado (HSL) com grau de hidrólise 10%] em comparação com a dieta padrão [caseína (CAS)], utilizadas como única fonte protéica em ratos submetidos ao exercício físico. Foram utilizados 96 ratos machos Wistar (~100g) divididos em grupos segundo o tipo de dieta (CAS, ISL e HSL) e a intensidade do exercício físico [treinados (T), treinados exaustos (TEX), sedentários (S) e sedentários exaustos (SEX)] durante 35 dias. Os seguintes parâmetros foram analisados: tempo de exaustão, concentração de lactato no sangue, glicogênio hepático (GH) e muscular (GM), atividade das enzimas marcadoras de lesão tecidual, incluindo lactato desidrogenase (LDH), creatina quinase (CK), alanina e aspartato aminotranferase (ALT e AST, respectivamente). Os animais alimentados com HSL nos grupos TEX e SEX conseguiram correr por muito mais tempo até atingir a exaustão em relação aos que receberam as dietas com CAS e ISL (p<0.05). O tempo de exaustão em relação à dieta CAS foi 72 min maior no grupo TEX e 44 min maior no grupo SEX. A diferença no tempo de exaustão entre os animais alimentados com as dietas de HSL e ISL foi de 40 min. no grupo TEX e de 13 min no grupo SEX. A concentração de lactato dos animais alimentados com ISL e HSL foi significativamente menor em relação aos alimentados com CAS nos grupos T e S (p<0,05). A concentração de glicogênio hepático dos animais que receberam as dietas com ISL e HSL foi estatisticamente superior em comparação com os que consumiram CAS nos grupos T(46%) e S (61%). A concentração de glicogênio muscular não apresentou diferenças significativas entre as três dietas nos diferentes grupos de treinamento (TEX, SEX, T e S). A atividade da ALT dos animais que consumiram HSL nos grupos SEX e S foi estatisticamente menor que os que receberam CAS. A atividade da AST dos animais alimentados com HSL foi significativamente menor que a dos que consumiram a dieta com CAS nos diferentes grupos de treinamento (TEX, SEX, T e S). A atividade da CK e LDH dos ratos que receberam a dieta com HSL foi estatisticamente menor que dos alimentados com CAS em todos os grupos de treinamento exceto no grupo S. Dos resultados obtidos neste trabalho pode-se concluir que o uso das proteínas do soro de leite [principalmente o hidrolisado (10% grau de hidrólise)] em relação à proteína padrão (CAS) como única fonte protéica em ratos submetidos a exercício físico, promoveu a) menor ganho de peso em todos os grupos, b) maior resistência à exaustão tanto no grupo TEX como no SEX, c) maior concentração de glicogênio hepático nos grupos T e S e d) maior proteção contra possíveis lesões hepáticas e musculares nos diferentes grupos estudados (TEX, SEX, T e S)
Abstract: The milk whey proteins are considered to be of high nutritive value and superior chemical score in comparison to other proteins of animal origin. They have high concentrations of branched-chain amino acids (BCAA) with excellent balance and bioavailability of essential amino acids. The milk whey proteins are widely used in the food industry as supplements for sportsmen due to their physiological and functional properties, and their hydrolysates are thought to be more efficient in the recovery of debilitated organisms under pronounced catabolic state because of their great stimulation to protein synthesis. In view of the energy value of proteins in exhaustive exercise, several studies on exercise and protein metabolism have been carried out in the attempt to elucidate the proper amount of protein that must be consumed by sportsmen. The present work had the objective of evaluating the metabolic changes induced by consumption of milk whey proteins [isolate (WPI) and its hydrolysate (WPH) with hydrolysis degree 10%] used as the only protein source in comparison to the standard diet [casein (CAS)] in rats submitted to physical exercise. 96 male Wistar rats (~100g) were divided in groups according to the type of diet (CAS, ISL and HSL) and the intensity of physical exercise [trained (T), trained taken to exhaustion (TEX), sedentary (S) and sedentary exhausted (SEX)] during 35 days. The following parameters were analyzed: time of exhaustion (min.), blood lactate concentration (mmol/L), liver glycogen (LG) and muscular glycogen (MG) (g/100g of tissue), activity of tissue injury marker enzymes (U/L) including lactate desidrogenase (LDH), creatine kinase (CK) and alanine and aspartate aminotranferase (ALT and AST respectively). The results showed that the animals fed with HSL in the groups TEX and SEX ran for much longer times until exhaustion in relation to the ones that received the diets with CAS and ISL (p<0.05). The exhaustion time in relation to the CAS diet was 72 min longer for the TEX group and 44 min longer for the SEX group. The difference in exhaustion time between the animals fed with the WPH and WPI diets was of 40 min for the group TEX and 13 min for the SEX group. The lactate concentration in the animals fed with WPI and WPH was statistically lower than in the ones fed with CAS in the groups T and S (p99<0,05). The concentration of liver glycogen in the animals that received the diets with WPI and WPH was statistically higher than in the animals that consumed CAS in the groups T (46%) and S (61%). The concentration of muscular glycogen did not have significant differences between the three types of diet in the different groups of training (TEX, SEX, T and S). The activity of the ALT of the animals that consumed WPH in the groups SEX and S was statistically lower than that of the animals that received CAS. The activity of the AST of the animals fed with WPH was significantly lower than that of the animals that consumed the diet with CAS in all of the groups of training (TEX, SEX, T and S). The activity of CK and LDH in the rats fed with HSL diet was statistical lower than in the ones fed with CAS in all of the groups of training except in the group S. From the results obtained in this work it can be concluded that the use of milk whey proteins [mainly the whey protein hydrolysate (10% hydrolysis degree)] in relation to the standard protein (CAS) as the only protein source in rats submitted to physical exercise promoted a) lesser weight gain in all of the groups, b) higher resistance to exhaustion in groups TEX and SEX, c) higher hepatic glycogen concentration in groups T and S and d) higher protection against possible hepatic and muscular injuries in all of the studied groups (TEX, SEX, T and S)
Doutorado
Nutrição Experimental e Aplicada à Tecnologia de Alimentos
Doutor em Alimentos e Nutrição

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24

Leão, Carolina Cauduro Bensabath Carneiro. "Composiçõa bioquimica dos musculos cardíaco e gastrocnemio, figado e sangue de ratos alimentados com proteina intacta e hidrolisada do soro do leite e submetidos a atividade fisica". [s.n.], 2009. http://repositorio.unicamp.br/jspui/handle/REPOSIP/254452.

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Orientador: Jaime Amaya Farfan
Dissertação (mestrado) - Universidade Estadual de Campinas, Faculdade de Engenharia de Alimentos
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Mestrado
Nutrição Experimental e Aplicada à Tecnologia de Alimentos
Mestre em Alimentos e Nutrição

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25

Bahia, Diogo Alexandre de Melo. "Sorte versus habilidade, uma abordagem através de cross section da indústria de fundos de ações no Brasil". reponame:Repositório Institucional do FGV, 2012. http://hdl.handle.net/10438/9970.

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Initially, we test the hypothesis that actively managed funds presents alphas (excess return) when compared to the Brazilian equity indexes used by passive funds. Then bootstrap simulations check if theses alphas can be attributed just to luck. Using this methodology we find that the aggregate portfolio of actively managed Brazilian equity funds has not presented excess of return from the two most important equity indexes in Brazil (true alpha), returns considered after cost and expenses. Bootstrap simulations suggests that a greater number of funds produces better returns adjusted to benchmark than we would expect just because of randomness in the returns.
Neste trabalho testa-se inicialmente se fundos com gestão ativa apresentam alfa (excesso de retorno) em relação aos índices de referência de fundos passivos. Simulações via bootstrap visam indicar se o excesso de retorno apresentado pode ser atribuído apenas à sorte. Com esta metodologia concluiu-se que a carteira agregada de fundos de investimentos de ação com gestão ativa no Brasil não apresenta excesso de retorno em relação aos principais índices da bolsa brasileira, quando líquidos de taxas e despesas. As simulações de bootstrap sugerem que uma quantidade maior de fundos apresenta retornos ajustados ao benchmark do que o esperado pelo efeito da aleatoriedade nos resultados.

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26

Geçgil, Tezcan Nurhan. "The intersection of transnational activism, power and soft law : how transnational advocacy networks may influence investor protection within the European Union". Thesis, University of East London, 2007. http://roar.uel.ac.uk/3842/.

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The international system is no longer just determined by states, but is also influenced by Transnational Advocacy Networks, TANs, which may include inter-governmental organisations, professional associations, and consumer groups. The scholarly community has also begun paying more attention to the actual significance of private authority in global governance and of soft law produced by international agreements. Within the European Union (EU), private authority and soft law has a special importance, whereby the Union encourages representatives of consumers, businesses, professional groups and national authorities to participate in the process of co-ordination and coregulation. At present investor protection is central to the EU's approach to financial services. The importance of the development of effective soft law standards and best practices in order to further the state of investor protection has become even more pronounced given the recent enlargement of the EU to 27 Member States. The general question that guides this study is how Translational Advocacy Networks (TANs) can exert power to enhance the state of investor protection within the new member states of the European Union (EU). CFA Institute, a TAN in investment management, constitutes the case study. Concentrating on CFA Institute as case study provides the opportunity to examine the professionalisation processes in the making. Professionalisation is characterised by the construction of acceptable knowledge claims and by the creation of an environment that is receptive to these claims. Similarly, TANs create policy expertise through the exchange of knowledge among stakeholders. Within the framework of CFA Institute, this dissertation uses the Foucauldian notions of power relations, discourse, and governmentality as well as the methodology offered by Actor Network Theory (ANT) to study and present a conceptual framework of best practices or conditions of possibility of TAN's employment of soft law. Many of the best practices in the successful application of soft law in general can be applied to investor protection in specific.

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27

Wellen, Jeremy W. "Characterization of soft-tissue response to mechanical loading using nuclear magnetic resonance (NMR) and functional magnetic resonance imaging (fMRI) of neuronal activity during sustained cognitive-stimulus paradigms". Link to electronic thesis, 2003. http://www.wpi.edu/Pubs/ETD/Available/etd-0430103-140128.

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Silva, José Dilson Francisco da. "Soro de leite bubalino hidrolisado com alcalase como agente de controle do escurecimento de maçãs minimamente processadas". reponame:Biblioteca Digital de Teses e Dissertações da UFRGS, 2017. http://hdl.handle.net/10183/164363.

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Enzimas proteolíticas são comumente empregadas na liberação de peptídeos bioativos com potencial aplicabilidade como aditivos em alimentos. Neste trabalho, estudou-se a capacidade de inibição do escurecimento de maçãs minimamente processadas do soro de leite de búfala hidrolisado por Alcalase em diferentes intervalos, ti (i = 0 h, 0,5 h, 1 h, 2 h, 3 h, 4 h ou 6 h). O processo de hidrólise foi acompanhado por determinação do grau de hidrólise (GH). Para se entender possíveis modos de ação sobre o escurecimento enzimático, o soro, ao longo do tempo de hidrólise, foi submetido às análises de capacidade capacidade antioxidante (capacidade de sequestro do radical ABTS•+, atividade quelante de Fe2+ e poder redutor), reatividade com quinonas e atividade inibitória sobre polifenoloxidases (PFO) extraídas de maçãs Red Delicious. Após os ensaios in vitro, o hidrolisado t4h foi testado quanto à capacidade de inibição do escurecimento de maçãs Red Delicious minimamente processadas, determinada por meio de análises de luminosidade (parâmetro L*) e índice de escurecimento (IE). O soro apresentou aumento significativo (p < 0,05) do GH, da atividade antioxidante, da reatividade com quinonas e da atividade inibitória de PFO em função do tempo de hidrólise. Especificamente para a atividade inibitória de PFO, o hidrolisado t4h alcançou pico de inibição próximo de 50 %. Quanto à capacidade de inibição do escurecimento das maçãs minimamente processadas, o hidrolisado manteve o parâmetro L* das maçãs durante 6 dias de armazenamento, não diferindo significativamente (p > 0,05) do metabissulfito. Além da luminosidade, o soro de leite hidrolisado conseguiu manter melhor o IE das maçãs durante esse tempo de armazenamento, comparativamente ao soro não hidrolisado (p < 0,05). Esses resultados evidenciam informações sobre possíveis aplicações de soro de leite bubalino hidrolisado com Alcalase como substituto natural de aditivos convencionalmente utilizados no controle desse tipo de escurecimento em alimentos.
Proteolytic enzymes are commonly employed in the release of bioactive peptides with potential applicability in food additives. In this work, the ability to inhibit the browning of minimally processed apples from Alcalase hydrolysed buffalo whey at different time, ti (i = 0 h, 0.5 h, 1 h, 2 h, 3 h, 4 h or 6 h). The hydrolysis process was followed by determination of the degree of hydrolysis (DH). In order to understand possible modes of action on the enzymatic browning, the whey was submitted to the analysis of the antioxidant capacity (capacity of sequestration of the ABTS•+ radical, Fe2+ chelating activity and reducing power), reactivity with quinones and inhibitory activity on polyphenoloxidases (PPO) extracted from Red Delicious apples. Following the in vitro assays, the t4h hydrolyzate was tested for the ability to inhibit the browning of minimally processed Red Delicious apples, determined by means of analysis of luminosity (parameter L *) and browning index (BI). Buffalo whey shows significant increase (p < 0.05) in DH, antioxidant activity, reactivity with quinones and PPO inhibitory activity as a function of the hydrolysis time. Specifically for the PPO inhibitory activity, the t4h hydrolyzate reached a near 50% inhibition peak. As for the ability to inhibit the browning of the minimally processed apples, the hydrolyzate kept the L * parameter of the apples during 6 days of storage, not statistically differing (p > 0.05) from the metabisulfite. In addition to the luminosity, the hydrolyzed whey was able to maintain the IE of the apples better during this storage time, compared to the unhydrolyzed whey (p < 0.05). These results evidenced information on possible applications of hydrolysed buffalo whey with Alcalase as a natural substitute for additives conventionally used in the control of this type of browning in foods.

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Slagle, Judith Bailey. "Literary Activism: James Montgomery, Joanna Baillie, and the Plight of Britain’s Chimney Sweeps". Digital Commons @ East Tennessee State University, 2012. https://dc.etsu.edu/etsu-works/720.

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Excerpt: On 6 February 1824, Joanna Baillie Notified Her Friend Walter Scott that Scottish poet James Montgomery, then living in Sherrield, England, had written to ask her for a poem on the plight on chimney sweeps, also known as climbing boys.

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Adolfsson, Johan. "Venture Capitalists on the Seed Stage Arena : A Fit or Misfit". Thesis, Linköping University, Department of Management and Economics, 2003. http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-1877.

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Background: Growth oriented entrepreneurial businesses need funding for the development of their idea, technology, product etc. However, for the businesses in the very earliest stages of development, access to funding is very limited. Growing young ventures are important job creators and positively affect growth in an economy. Bridging the gap of funding to these companies is therefore on the agenda of governments around the world.

Purpose: To describe the situation facing seed stage investing venture capitalists. I will emphasize difficulties and evaluate venture capitalists ability in addressing them. Effects of the difficulties in form of access to financing for entrepreneurs and a possible need for government intervention will be examined.

Method: Empirical information from seed stage investing venture capital organizations have been collected in the form of face-to-face interviews, email- questionnaires and a telephone interview. Organizations from Sweden, Denmark and Germany are included in the study.

Result: Several factors make seed stage investing unattractive compared to later stages. Important difficulties are higher risks, high costs for fund management, goal incongruence in the investor – venture capitalist relation and lack of bargaining power for seed venture capitalists. Environmental factorsthat have an impact on seed investing are the deal flow, the investment climate and access to soft funding. Seed stage investing is a very challenging business and the difficulties are to a large extent hard to overcome. The investors more likely have to accept them and I conclude that long term profitability of seed funds is unlikely, at least in absence of government support in form of soft funding towards the entrepreneurial businesses.

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31

Calmet, Michel. "FAUT-IL ENSEIGNER LE JUDO OU LE SAVOIR COMBATTRE ?Les démarches éducatives scolaires peuvent-elles intégrer les activités physiques de combat ?Les activités physiques de combat sont-elles intégrées entièrement en Education Physique et Sportive ?" Phd thesis, Université de Picardie Jules Verne, 2002. http://tel.archives-ouvertes.fr/tel-00407537.

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Les sports de combat et arts martiaux sont toujours présentés comme éducatifs et restent peu pratiqués en éducation physique.
Pourtant on peut considérer que les sports de combat appartiennent au patrimoine de l'humanité et que depuis la Révolution Française, les activités physiques de combat ont été régulièrement inscrites dans les programmes officiels d'enseignement de l'EPS.
L'étude de ces activités au moyen d'enquêtes (1188 questionnaires analysés avec une application que nous avons réalisée), d'analyses de discours d'experts et d'articles (21 études) et d'analyses de résumés de communication (212 études), précise le positionnement des différents "acteurs" (judokas, élèves, étudiants, enseignants) du judo, des sports de combat et de l'éducation physique.
Les résultats montrent que le judo n'est pas réductible au savoir combattre, et que le côté "multiforme" comprenant les finalités éducatives, les combats sans enjeu, mais aussi les approches techniques, la self-défense doit être mis en avant de façon à dégager des stratégies de progrès pour tous, apprenants et enseignants.

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32

Arti, Sulaiman. "Continuity and change in Hollywood representations of the Middle East after September 11th". Thesis, Loughborough University, 2009. https://dspace.lboro.ac.uk/2134/16858.

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This thesis inquires into the factors behind Hollywood's depiction of the Middle East. That depiction is not static, but is modified in response to changes in political events and US government foreign policy. Although the events of 9/11 seemed to justify the traditional negative stereotype of Arabs, the image has been partially and rationally re-interpreted. This was due to the rise in prominence of the ideas of a minority of radical and free-thinking members of the Hollywood community who embraced a more intellectual approach, which advocated that the popular Western view of the Arab world was unjustified and based on a fallacious fabrication for Western political advantage. The research further shows that these activists did not owe allegiance to the Hollywood-US government propaganda machine. They were able to fracture this traditional alliance and provide the opportunity for the appearance of films of a radical nature, which were critical of US Middle Eastern policy and projected the Arab world in a new light. The study analyzes a selection of films that represent the Middle East in terms of their philosophy and cinematic structure, which enables them to act as vectors to raise public awareness of the issues and to promote reconciliation and co-existence between East and West.

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33

Bedford, Sofie. "Islamic Activism in Azerbaijan : Repression and Mobilization in a Post-Soviet Context". Doctoral thesis, Stockholm : Huddinge : Department of Political Science, Stockholm University ; Södertörns högskola, 2009. http://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-8429.

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Orange, Nicole. "Analyse biochimique de la membrane du CIV (chilo iridescent virus, type 6) et caractérisation à l'aide d'anticorps monoclonaux des activités biologiques qui lui sont associées". Rouen, 1986. http://www.theses.fr/1986ROUES017.

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Odin, Pierre. ""Travayè an larila - Les travailleurs sont dans la rue" : syndicalisme et protestation en Guadeloupe et en Martinique". Thesis, Paris, Institut d'études politiques, 2017. http://www.theses.fr/2017IEPP0027/document.

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En janvier 2009, une grève générale de 44 jours était déclenchée à l’appel du Liyannaj Kont Pwofitasyon - pour « Unité contre l’exploitation » en Guadeloupe et du Kolectif 5 Févrié - « Collectif du 5 février » en Martinique. Ces deux coalitions menées par des syndicalistes entendaient alors mobiliser la population locale contre la cherté de la vie aux Antilles, en soulignant le caractère inégalitaire et colonial de ce phénomène. La première partie de ce travail entend exposer la genèse du syndicalisme aux Antilles : d’abord, en décrivant l’influence des événements de Mai 68 sur la jeunesse anticolonialiste antillaise ; ensuite, en analysant les trajectoires des militants anticolonialistes qui se sont tourné vers le syndicalisme à la fin des années 1970. La deuxième partie est consacrée à l’encadrement politique des syndicats antillais contemporains, au sein de quatre organisations : l’Union Générale des Travailleurs de la Guadeloupe (UGTG), la Confédération Générale du Travail (CGTG et CGTM) et la Confédération Démocratique des Travailleurs Martinique (CDMT). Plus spécifiquement, il sera ici question de la façon dont l’indépendantisme et les différents courants d’extrême gauche parviennent à imprimer et à maintenir leurs orientations politiques tout en composant avec la diversité des publics auprès desquels interviennent les syndicats. Notre troisième partie revient quant à elle sur la situation de conflit social généralisé qui surgit à la faveur de la grève générale de 2009, en analysant le travail de coalition entre les différents acteurs protestataires, les négociations avec les autorités de l’île et la dynamique de radicalisation du conflit
In January 2009, a general strike, that would last 44 days, broke out following the call of the Liyannaj Kont Pwofitasyon (“Unite against exploitation”) in Guadeloupe and of the Kolectif 5 Févrié (“Collective of February 5th”) in Martinique. Those two coalitions led by union leaders sought to mobilize the local population against the high cost of living in the Antilles, insisting on the unequal and colonial dimensions of this phenomenon. The first part of this work tackles the genesis of unionism in the Antilles: first by describing the influence of May 1968 events on the anticolonial youth in those islands; then by analyzing the trajectories of the anticolonial activists who turned toward unionism at the end the 1970s. The second part of the dissertation is dedicated to the study of contemporary union’s political culture, throughout the analysis of four organizations: the Union Générale des Travailleurs de la Guadeloupe (UGTG), the Confédération Générale du Travail (CGTG and CGTM), and the Confédération Démocratique des Travailleurs de Martinique (CDMT). More specifically, it will uncover the way separatism and the various branches of the far-left succeed in imposing and maintaining their political options while dealing with the diversity of the constituents that the unions serve. The third part will focus on the situation of widespread social unrest, which emerged as a result of the 2009 general strike. It will analyze the coalition work of the various protesting groups, the collective bargaining with local authorities and the dynamics of conflict radicalization

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36

Réguer-Petit, Léa. "L'appréhension par le droit de l'Union européenne des sanctions dans le domaine des activités sportives". Thesis, Paris 9, 2015. http://www.theses.fr/2015PA090039/document.

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Le sport européen est à la veille d'un bouleversement quant à sa prise en compte par le droit de l'UE et par le droit de la Convention européenne des droits de l’homme. Le constat du chevauchement de normes et de référentiels juridiques différents produisant des effets sur les sanctions infligées au « sportif citoyen européen » conduit à la répétition de difficultés relatives à la violation des principes d'égalité de traitement et d'intégrité des compétitions sportives. Cette thèse démontre la nécessité d'une européanisation des sanctions infligées au « sportif citoyen européen », et propose une réflexion sur les instruments juridiques de droit souple et de droit dur - existants ou à exploiter - susceptibles de répondre à cet objectif d'européanisation. L'originalité des travaux réside d'abord dans la réalisation d'enquêtes de terrain, puis dans le développement et les modifications à venir d'instruments de droit souple ou de droit dur existants, aux fins de combattre les atteintes aux principes précités en contribuant, de diverses façons, à l'européanisation des sanctions dans le domaine des activités sportives
European sport is on the verge of an upheaval as to its consideration by EU law and by the law of the European Convention on Human Rights. The finding of overlapping standards and different legal frameworks producing effects on the sanctions on the "European citizen athlete" leads to the repetition of difficulties relating to the infringement of the principles of equal treatment and of integrity of sport competitions. This thesis demonstrates the need for Europeanisation of sanctions imposed on the "European citizen athlete", and develops a reflection on the legal instruments of soft law and hard law - existing or to be developed - that may be of interest to meet that objective of Europeanisation. The originality of the work primarily lies in conducting field surveys, and secondly in the development and future changes in instruments of soft law or hard law existing for the purpose of combating violations of these principles, by contributing in various ways, to the Europeanisation of sanctions in the field of sports

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37

Saraf, Shashank. "Tailoring the Properties of Polyelectrolyte Coated Cerium Oxide Nanoparticles as a Function of Molecular Weight". Master's thesis, University of Central Florida, 2013. http://digital.library.ucf.edu/cdm/ref/collection/ETD/id/6351.

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The application of Cerium oxide nanoparticles (CNPs) for therapeutic purposes requires a stable dispersion of nanoparticles in biological environment. The objective of this study is to tailor the properties of polyelectrolyte coated CNPs as a function of molecular weight to achieve a stable and catalytic active dispersion. This was achieved by coating CNPs with polyacrylic acid (PAA) which increased the dispersion stability of CNPs and enhanced the catalytic ability. The stability of PAA coating was analysed using the change in the Gibbs free energy computed by Langmuir adsorption model. The adsorption isotherms were determined using soft particle electrokinetics which overcomes the challenges presented by other techniques. The Gibbs free energy was highest for PAA coated CNPs by 250 kg/mole indicating the most stable coating. The free energy for PAA 100 kg/mole coated CNPs is 85% lower than the PAA250 coated CNPs. This significant difference is caused by the strong adsorption of PAA100 on CNPs. Catalytic activity of PAA-CNPs is accessed by the catalase enzymatic activity of nanoparticles. The catalase activity was higher for PAA coated CNPs as compared to bare CNPs which indicated preferential adsorption of hydrogen peroxide induced by coating. Apart from PAA coating the catalase activity is also affected by the structure of the coating layer.
M.S.M.S.E.
Masters
Materials Science Engineering
Engineering and Computer Science
Materials Science and Engineering

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38

Boško, Borković. "Fitohemijska analiza i antioksidantni kapacitet plodova trešnje inficiranih gljivom Monilinia laxa Aderh. i Ruhl". Phd thesis, Univerzitet u Novom Sadu, Poljoprivredni fakultet u Novom Sadu, 2019. https://www.cris.uns.ac.rs/record.jsf?recordId=107893&source=NDLTD&language=en.

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Mrka trulež, čiji je prouzrokovač Monilinia laxa, spada u najčešče i najznačajnije bolesti ploda koštičavih voćaka, naročito trešnje. Cilj ovog rada je bio da se utvrde razlike u reakciji devet sorti plodova trešnje (različitih pomoloških osobina) prema mrkoj truleži, uzorkovanih sa oglednog dobra Departmana za voćarstvo i vinogradarstvo, Poljoprivredni fakultet Novi Sad na Rimskim Šančevima (koordinate: 45°20´N, 19°51´E). S obzirom da se u prirodnim uslovima plod trešnje može zaraziti od strane više patogena, biohemijski parametri su analizirani i na veštački inokulisanim plodovima. Ispitivane sorte su pokazale značajne razlike u pojavi oboljenja na plodu, kako u uslovima veštačke inokulacije, tako i u prirodnoj infekciji. U oba slučaja kod sorti su zabeležene različite ocene intenziteta zaraze, zavisno od sortimenta. Biohemijskom analizom plodova zabeležene su značajne razlike u sadržaju rastvorljivih proteina (SP), aktivnosti supereksid dismutaze (SOD), aktivnosti gvajakol peroksidaze (GPx), aktivnost pirogalol peroksidaze (PPx), lipidnoj peroksidaciji (LP). Utvrđene su značajne razlike u sadržaju šećera, organskih kiselinih i sekundarnih metabolita (fenoli, tanini, proantocijanidini, flavonoidi, antocijanini). Takođe rezultati su pokazali razlike u antioksidantnoj aktivnost (DPPH, FRAP, ABTS i TRC testovi). Na sadržaj sekundarnih biomolekula kao i na antioksidantnu aktivnost uticali su sorta, intenzitet zaraze ploda, kao i interakcija između ova dva faktora. Većina ispitivanih sorti je pokazala visok sadržaj polifenolnih komponenti, dok je u uslovima infekcije,
Fitohemijska analiza i antioksidantni kapacitet plodova trešnje inficiranih gljivom Monilinia laxa Aderh i Ruhl, B. Borković

sadržaj ovih parametara bio značajno niži. Na osnovu dobijenih razultata, sadržaj sekundarnih metabolita se može koristiti kao jedan od parametara u oceni otpornosti sorti trešnje prema mrkoj truleži. Datum

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39

Svetlana, Bošković. "Fitohemijski sastav, lekoviti potencijal i senzorne karakteristike sorti vrsta Brassica oleracea L. i Brassica rapa L. (Brassicaceae) iz organskog i konvencionalnog sistema proizvodnje". Phd thesis, Univerzitet u Novom Sadu, Prirodno-matematički fakultet u Novom Sadu, 2016. https://www.cris.uns.ac.rs/record.jsf?recordId=101645&source=NDLTD&language=en.

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U ovom radu su ispitani hemijski sastav i biološka aktivnost vrsta Brassica oleracea i Brassica rapa poreklom iz organskog i konvencionalnog sistema proizvodnje. Ispitivanja hemijskog sastava su obuhvatila određivanje volatilnih komponenata primenom headspace GC-MS tehnike, kvalitativnu analizu sokova ispitivanih vrsta pomoću LC-DAD-MS/MS tehnike, kvantifikaciju odabranih fenolnih jedinjenja pomoću LC-MS/MS tehnike i spektrofotometrijsko određivanje sadržaja ukupnih glukozinolata, fenola i flavonoida i sadržaja ukupnih monomernih antocijana. Biološka aktivnost povrća je ispitana određivanjem antioksidantnog potencijal, antimikrobne i antitumorske aktivnosti sokova. Dobijeni rezultati pokazuju da su glavne volatilne komponente ispitivanih vrsta degradacioni proizvodi masnih kiselina i organosumpornih jedinjenja od kojih neke od identifikovanih komponenata predstavljaju ključne mirisne komponente. Na osnovu njihove distribucije nije bilo moguće utvrditi uticaj sistema proizvodnje na miris i ukus ispitivanih vrsta. Pomoću LC-DAD-MS/MS i LC-MS/MS tehnike je utvrđeno prisustvo primarnih metabolita, slobodnih hidroksibenzoevih i hidroksicimetnih kiselina, derivate hinske kiseline sa hidroksicimetnim kiselinama, glikozida flavonola, biflavonoida, i kumarina u sokovima spitivanih vrsta. Pored toga u svim sokovima subili prisutni kondenzacioni proizvodi degradacionih proizvoda indolnih glukozinolata sa askorbinskom kiselinom- askorbigen i metoksiaskorbigen. U sokovima crvenog kupusa su bili prisutni antocijani. Najveći sadržaj ukupnih glukozinolata je određen u brokoliju, dok je crveni kupus sadržao najveći sadržaj ukupnih fenola ukupnih flavonoida kao i hinske kiseline. Crveni kupus je bio varijetet koji je ispoljio najviši antioksidantni kapacitet u svim primenjenim testovima, brokoli i karfiol su ispoljili najjaču antimikrobnu aktivnost, dok je kelj bio varijetet sa najjačim antitumorskim delovanjem. Na osnovu analize hemijskog sastava i biološke aktivnosti vrsta B. oleracea i B. rapa može se zaključiti da u zavisnosti od primenjenog tipa proizvodnje mogu biti poboljšane neke od karakteristika ispitivanih vrsta i da je uticaj sistema proizvodnje značajan za pojedine varijetete, a nikako za celu vrstu. U konačnom obliku može se zaključiti da bi potencijalna kombinacija sokova crvenog kupusa, brokolija, karfiola i kelja mogla ostvariti značajno hemopreventivno i hemoterapeutsko delovanje, ispoljavajući istovremeno antioksidantnu, antimikrobnu i antitumorsku aktivnost.
Chemical composition and biological activity of Brassica oleracea and B. rapa species were investigated in the present work. Investigation of chemical composition encompassed determination of volatile compounds by headspace GC-MS technique, qualitative analysis of juices of investigated vegetables by LC-DAD-MS/MS technique, quantification of selected phenolic compounds by LC-MS/MS technique and spectrophotometric determination of total content of glucosinolates, phenolic compounds and flavonoids and total content of monomeric anthocyanes. Biological activity of vegetables was investigated by determination of antioxidant capacity, antimicrobial and antitumorigenic effect of juices. Obtained results showed that main volatile compounds were degradation products of fatty acids and organo-sulphur compounds among which some of the identified components were the key aroma compounds. Based on their distribution it was not possible to evaluate influence of cropping system on aroma and taste of investigated species. By LC-DAD-MS/MS and LC-MS/MS techniques, it was determined the presence of primary metabolites, freehydroxybenzoic and hydroxycinnamic acids, derivatives of quinic acid and hidroxicinnamic acids, flavonol glucosides, biflavnoids and a cumarin in juices of the investigated species. Furthermore, condensation products of degradation products of indole glucosinolates with ascorbic acid- ascorbigen and metoxiascorbigen were present in all juices. Anthocyanes were present in juices of red cabbage. The highest total content of glucosinolates was determined in broccoli, while red cabbage had the highest total phenolic content, total flavonoid content, as well as content of qunic acid. Red cabbage was a variety that showed the highest antioxidant capacity measured by different assays. Broccoli and cauliflower expressed the highest antimicrobial potential, while Savoy cabbage was a variety with the highest antitumor effect. Investigation of chemical composition and biological activity showed that applied cropping conditions may be useful for improving some of the characteristics of investigated species and significance of cropping system only for particular varieties, but not for the whole species in general. As the conclusion, potential combination of juices of red cabbage, broccoli, cauliflower and Savoy cabbage could be potent chemopreventive and chemotherapeutic agent, expressing simultaneously antioxidant, antimicrobial and antitumor activity.

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40

Bertolini, Martinna de Mendonça e. "Avaliação in vitro de duas resinas macias para reembasamento de próteses modificadas pela incorporação de clorexidina". Universidade do Estado do Rio de Janeiro, 2011. http://www.bdtd.uerj.br/tde_busca/arquivo.php?codArquivo=8437.

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Resinas macias para reembasamento de próteses são largamente utilizadas após cirurgias para estabilizarem a prótese e condicionarem o tecido, aguardando a completa cicatrização. É importante que o material não seja facilmente colonizado por biofilme oral e se possível, evite a contaminação do sítio cirúrgico. Objetivou-se avaliar o efeito da incorporação de clorexidina às resinas acrílicas macias para o reembasamento de próteses totais, através de análises de liberação, citotoxicidade e efeito inibitório de um biofilme de C. albicans. Foram confeccionados corpos de provas (CDPs) com as resinas Trusoft e Coe-soft, com incorporação de 0%, 0,5%, 1,0% e 2,0% de clorexidina, totalizando 8 grupos. A liberação de clorexidina foi avaliada através da mensuração da mudança na densidade óptica da solução de armazenamento, na qual ficaram imersos os CDPs, por espectrometria UV, a cada 48 horas, durante 40 dias. A citotoxicidade celular foi avaliada em fibroblastos (linhagem L929), que ficaram 24 horas em contato com meio de cultura no qual os CDPs ficaram previamente imersos, pela técnica de absorção de corante vermelho neutro após 24, 48 e 72 horas e semanalmente até o 28 dia. E, por fim, a atividade antifúngica contra a C. albicans (ATCC 10231) foi avaliada de duas maneiras: (1) teste de difusão em ágar, no qual os CDPs foram colocados em placas de BHI previamente inoculadas com C. albicans, com medição do halo de inibição após 48 horas de incubação a 37C; (2) a avaliação da inibição da formação de um biofilme de C. albicans sobre a superfície dos CDPs pela quantificação por metil tetrazólio (MTT) a cada 48 horas, durante 22 dias, com leitura feita em espectrofotômetro de UV. Os dados obtidos foram inseridos no programa SigmaStat (versão 3.1, USA) para realizar as análises estatísticas. As diferenças estatísticas foram determinadas por análises de variâncias do tipo ANOVA e todos os procedimentos para comparações múltiplas pareadas foram feitos utilizando-se o método Holm-Sidak, com nível de significância global igual a 0,05. A clorexidina adicionada às resinas testadas foi capaz de ser liberada para o meio de armazenagem, proporcionalmente à quantidade de clorexidina incorporada, porém com diferentes cinéticas de liberação entre as resinas, visto que a Trusoft libera até 71% do total de clorexidina liberada nas primeiras 48 horas e a Coe-soft, até 44%. Ambas as resinas com incorporação de clorexidina apresentaram efeito citotóxico adicional, se comparadas às resinas sem clorexidina, porém para a Coe-soft não houve diferença estatística dos valores, apenas para a Trusoft (p<0,001). Ocorreu formação de halo de inibição proporcionalmente às concentrações de resinas adicionadas, com maiores halos para a resina Trusoft (p<0,001), e sem formação de halo para as resinas sem clorexidina; a inibição da formação de biofilme, realizada somente com a resina Coe-soft, mostrou total inibição durante 8, 12 e 16 dias, para a incorporação de 0,5%, 1,0% e 2,0% respectivamente, sendo uma diminuição estatisticamente significativa (p<0,001) em relação à resina sem incorporação de clorexidina, que não apresentou inibição do biofilme.
Denture soft lining materials are widely used after dental surgeries, tissue conditioning and stabilization of prostheses, until the complete tissue healing. It is important that this material not became easily colonized by oral biofilm and if possible, avoid contamination of the surgical site. The aim of this study was to evaluate the effect of chlorhexidine incorporation into resin-based soft denture lining material, considering the drug release analysis, cytotoxicity and C. albicans biofilm inhibition. Specimens were done using Trusoft and Coe-soft, incorporating 0%, 0.5%, 1.0% and 2.0% of chlorhexidine, totaling eight groups. The chlorhexidine release was evaluated through the measurement of change in optical density of the storage solution, which the specimens were immersed, by UV spectrometry, after every 48 hours for 40 days. The cellular cytotoxicity was evaluated in fibroblasts (strain L929), which were 24 hours in contact with culture medium, in which the specimens were previously immersed, the technique of neutral red dye uptake was used after 24, 48 and 72 hours and weekly until 28th day. Finally, the antifungal activity against C. albicans (ATCC 10231) was evaluated by two different ways: (1) agar diffusion test, in which the specimens were placed over the top of BHI agar plates previously inoculated with C. albicans, and the measurement of inhibition zone was done after 48h of incubation at 37C, (2) C. albicans biofilm inhibition over the specimens surface, which was mensured after every each 48 hours of biofilm and specimens co-incubation, by methyl tetrazolium (MTT), in UV/vis spectrophotometer, during 22 days. Data were analyzed with the SigmaStat software (version 3.1, USA). Statistical differences were determined by analysis of variance ANOVA and all procedures for multiple paired comparisons were made using the Holm-Sidak method, with overall significance level of 0.05. The chlorhexidine added to both resins, Trusoft and Coe-soft, can be released to the storage medium, with a dose-related effect, however the resins presented different release kinetics, since the Trusof released up to 71% of the total amount of the chlorhexidine released within the first 48 hours and Coe-soft release only up to 44%, considering the citotoxic effect, both chlorhexidine incorporated resins showed some extra cytotoxic effect, if compared to resins without chlorhexidine, but for Coe-soft no statistical difference of values was founded, only for Trusoft (p<0.001); considering the C. albicans inhibition, the agar diffusion test values were dose-related for both resins, however with bigger inhibition zones for Trusoft (p<0.001), and without any inhibition for the resins without clorexidine. For the C. albicans biofilm inhibition test, performed only with Coe-soft resin, it was verified a complete inhibition at 8, 12 and 16 days for the incorporation of 0.5%, 1.0% and 2.0% of clorexidine respectively, a statistically significant decrease (p<0.001) if compared to the resin without incorporation of chlorhexidine, which showed no inhibitory effect over the biofilm formation.

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41

Camara, El Hadji Habib. "Intelligibilité de l'activité du professeur en classe par la co-disciplinarité : Quels sont les processus sous-jacents à une telle activité sur le plan didactique et pédagogique en classe de géographie de l'enseignement moyen et secondaire au Sénégal ?" Caen, 2009. http://www.theses.fr/2009CAEN1530.

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Diverses préoccupation révélatrices de la complexité de l'acte d'enseigner sont à la base de la recherche sur l'activité de l'enseignant en classe ; il s'agit de l'appréhension dichotomique du "double agenda" pédagogique et didactique dans la plupart des travaux de recherche en éducation, du manque de connaissance théorique que les professeurs ont de leur activité, et de la spécificité que la géographie est censée conférer à leur enseignement. En partant de l'idée que d'une part la didactique ne peut être dissociée de la pédagogie, et d'autre part que la pratique ne se conçoit pas sans théorie en milieu scolaire, nous avons cherché à circonscrire l'activité du professeur en classe de géographie de l'enseignement moyen et secondaire au Sénégal, d'un point de vue psychologique et didactique. Pour cela, il a été fait recours à la littérature empirique et théorique sur l'activité de l'enseignant pour élaborer un modèle de traitement, offrant la possibilité d'appréhender cette activité dans sa double dimension didactique et pédagogique. La constitution du matériel d'analyse procède d'un enquête menée sur la base d'observations de classe suivies d'entretiens et de questionnaires, auprès d'une dizaine de professeurs. Ce matériel collecté a été soumis, dans une perspective d'analyse qualitative, à une double lecture extrinsèque et intrinsèque qui a révélé l'existence de deux ensembles de processus, en rapport avec les pratiques d'enseignement dans l'enseignement moyen et secondaire au Sénégal, nous amenant ainsi à soutenir l'idée que l'orientation classique ou innovante de la pratique d'enseignement de la géographie dépend de la nature des processus activés et de leur co-ocurrence.

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42

Kočí, Jakub. "Unie studentů VŠE ze systémového pohledu". Master's thesis, Vysoká škola ekonomická v Praze, 2014. http://www.nusl.cz/ntk/nusl-193563.

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The aim of this diploma thesis is the preparation and foundation of the Students' Union of the University of Economics in Prague, which is done by Soft systems methodology. In order to achieve this aim, the thesis elaborates a theory of student organizations and student unions in the Czech Republic. It also compares a set of rules governing student organizations at chosen Czech universities with chosen foreign universities. The result of this comparison is that chosen foreign universities have more systematic policies towards their student organizations. The research part of this thesis contains Analysis two (social) and Analysis three (political) from the Soft systems methodology. The results of the research contains defined set of roles, norms, values and a distribution of power in the environment of student organizations at University of Economics. Practical part of the thesis brings two complete learning cycles of the Soft systems methodology including root definitions, CATWOE and models of purposeful activity. Based on these two learning cycles, the thesis defines the general limits of Soft system methodology for the foundation of student union at Czech universities.

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43

Hovhannisyan, Yeranuhi. "Modélisation cardiaque des myopathies myofibrillaires à l'aide de cellules souches pluripotentes induites pour explorer la pathogenèse cardiaque Polyacrylamide Hydrogels with Rigidity-Independent Surface Chemistry Show Limited Long-Term Maintenance of Pluripotency of Human Induced Pluripotent Stem Cells on Soft Substrates Modéliser la myopathie myofibrillaire pour élucider la pathogenèse cardiaque Synemin-related skeletal and cardiac myopathies: an overview of pathogenic variants Desmin prevents muscle wasting, exaggerated weakness and fragility, and fatigue in dystrophic mdx mouse Effects of the selective inhibition of proteasome caspase-like activity by CLi a derivative of nor-cerpegin in dystrophic mdx mice". Thesis, Sorbonne université, 2020. http://www.theses.fr/2020SORUS095.

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La myopathie myofibrillaire est une maladie neuromusculaire à évolution lente caractérisée par de graves troubles musculaires causés par des mutations dans le gène codant pour des protéines du cytosquelette. L'un des gènes affectés en relation avec le développement de la MFM est DES. Des mutations dans le gène de la desmine entraînent des myopathies des muscles squelettiques et cardiaques. Cependant, les évènements qu'elles entraînent et qui sont à l’origine des phénotypes pathologiques cardiaques restent mal connus. Mon objectif est de créer un modèle in vitro de MFM basé sur des cellules souches pluripotentes humaines afin d'étudier le rôle des mutations spécifiques dans la desmine sur le développement et la fonction des cellules cardiaques. Pour atteindre cet objectif, en collaboration avec les docteurs A. Behin, K. Wahbi et la société Phenocell, nous avons généré des iPSC à partir des cellules sanguines périphériques de patients souffrant d'une forme de cardiomyopathie induite par une mutation de la desmine. Les lignées iPSC générées contenant les mutations du gène codant la desmine ont permis d’étudier le rôle d’une mutation dans la spécification et la fonction des cardiomyocytes. La bioénergétique mitochondriale, la structure cellulaire et la fonction contractiles ont été évaluées au niveau cellulaire. En conclusion, il convient de noter que les mutations de la desmine conduisent à une désorganisation des structures des sarcomères dans les cardiomyocytes et à une perturbation de l'expression des protéines mitochondriales. Ce qui conduit à une altération des fonctions de la mitochondrie. Ces données permettent d’améliorer notre compréhension des mécanismes moléculaire qui sous-tendent le développement de la MFM
Myofibrillar Myopathy is a slowly progressive neuromuscular disease characterized by severe muscular disorders caused by mutations in the gene encoded cytoskeletal proteins. One of the genes described in connection with the development of MFM is DES. Mutations in the desmin gene lead to skeletal and cardiac muscles myopathies. However, the cardiac pathological consequences caused by them remain poorly understood. My objective is to create an in vitro human stem cell model of MFM to specifically investigate the role of patient-specific mutations in desmin on cardiac lineage development and function. To achieve that objective, in collaboration with Drs. Behin and K. Wahbi and Phenocell, we generate patient-specific iPSC from peripheral blood cells of the patient suffering severel form of desmin-deficient cardiomyopathy. The generated iPSC lines carrying DES gene mutations enable a powerful examination of the role of desmin mutation on cardiomyocyte specification and function. Bioenergetic, structural, and contractile function will be assessed in a single cell. In conclusion, it should be noted that desmin mutations lead to a disorganization of sarcomere structures in cardiomyocytes and to a perturbation of mitochondrial protein expression. This leads to a distortion of functions in the mitochondria. These data facilitate the understanding of the molecular pathway underlying the development of desmin-related myopathy. And the system we have created could also allow us to better evaluate the correlation between the desmin genotype and phenotype in terms of effect on the heart

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44

Fenollosa, Artés Felip. "Contribució a l'estudi de la impressió 3D per a la fabricació de models per facilitar l'assaig d'operacions quirúrgiques de tumors". Doctoral thesis, Universitat Politècnica de Catalunya, 2019. http://hdl.handle.net/10803/667421.

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La present tesi doctoral s’ha centrat en el repte d’aconseguir, mitjançant Fabricació Additiva (FA), models per a assaig quirúrgic, sota la premissa que els equips per fer-los haurien de ser accessibles a l’àmbit hospitalari. L’objectiu és facilitar l’extensió de l’ús dels prototips com a eina de preparació d’operacions quirúrgiques, transformant la pràctica mèdica actual de la mateixa manera que en el seu moment ho van fer tecnologies com les que van facilitar l’ús de radiografies. El motiu d’utilitzar FA, en lloc de tecnologies més tradicionals, és la seva capacitat de materialitzar de forma directa les dades digitals obtingudes de l’anatomia del pacient mitjançant sistemes d’escanejat tridimensional, fent possible l’obtenció de models personalitzats. Els resultats es centren en la generació de nou coneixement sobre com aconseguir equipaments d’impressió 3D multimaterials accessibles que permetin l’obtenció de models mimètics respecte als teixits vius. Per facilitar aquesta buscada extensió de la tecnologia, s’ha focalitzat en les tecnologies de codi obert com la Fabricació per Filament Fos (FFF) i similars basades en líquids catalitzables. La recerca s’alinea dins l’activitat de desenvolupament de la FA al CIM UPC, i en aquest àmbit concret amb la col·laboració amb l’Hospital Sant Joan de Déu de Barcelona (HSJD). El primer bloc de la tesi inclou la descripció de l’estat de l’art, detallant les tecnologies existents i la seva aplicació a l’entorn mèdic. S’han establert per primer cop unes bases de caracterització dels teixits vius -sobretot tous- per donar suport a la selecció de materials que els puguin mimetitzar en un procés de FA, a efectes de millorar l’experiència d’assaig dels cirurgians. El caràcter rígid dels materials majoritàriament usats en impressió 3D els fa poc útils per simular tumors i altres referències anatòmiques. De forma successiva, es tracten paràmetres com la densitat, la viscoelasticitat, la caracterització dels materials tous a la indústria, l’estudi del mòdul elàstic de teixits tous i vasos, la duresa d’aquests, i requeriments com l’esterilització dels models. El segon bloc comença explorant la impressió 3D mitjançant FFF. Es classifiquen les variants del procés des del punt de vista de la multimaterialitat, essencial per fer models d’assaig quirúrgic, diferenciant entre solucions multibroquet i de barreja al capçal. S’ha inclòs l’estudi de materials (filaments i líquids) que serien més útils per mimetitzar teixits tous. Es constata com en els líquids, en comparació amb els filaments, la complexitat del treball en processos de FA és més elevada, i es determinen formes d’imprimir materials molt tous. Per acabar, s’exposen sis casos reals de col·laboració amb l’HJSD, una selecció d’aquells en els que el doctorand ha intervingut en els darrers anys. L’origen es troba en la dificultat de l’abordatge d’operacions de resecció de tumors infantils com el neuroblastoma, i a la iniciativa del Dr. Lucas Krauel. Finalment, el Bloc 3 té per objecte explorar nombrosos conceptes (fins a 8), activitat completada al llarg dels darrers cinc anys amb el suport dels mitjans del CIM UPC i de l’activitat associada a treballs finals d’estudis d’estudiants de la UPC, arribant-se a materialitzar equipaments experimentals per validar-los. La recerca ampla i sistemàtica al respecte fa que s’estigui més a prop de disposar d’una solució d’impressió 3D multimaterial de sobretaula. Es determina que la millor via de progrés és la de disposar d’una pluralitat de capçals independents a fi de capacitar la impressora 3D per integrar diversos conceptes estudiats, materialitzant-se una possible solució. Cloent la tesi, es planteja com seria un equipament d’impressió 3D per a models d’assaig quirúrgic, a fi de servir de base per a futurs desenvolupaments.
La presente tesis doctoral se ha centrado en el reto de conseguir, mediante Fabricación Aditiva (FA), modelos para ensayo quirúrgico, bajo la premisa que los equipos para obtenerlos tendrían que ser accesibles al ámbito hospitalario. El objetivo es facilitar la extensión del uso de modelos como herramienta de preparación de operaciones quirúrgicas, transformando la práctica médica actual de la misma manera que, en su momento, lo hicieron tecnologías como las que facilitaron el uso de radiografías. El motivo de utilizar FA, en lugar de tecnologías más tradicionales, es su capacidad de materializar de forma directa los datos digitales obtenidos de la anatomía del paciente mediante sistemas de escaneado tridimensional, haciendo posible la obtención de modelos personalizados. Los resultados se centran en la generación de nuevo conocimiento para conseguir equipamientos de impresión 3D multimateriales accesibles que permitan la obtención de modelos miméticos respecto a los tejidos vivos. Para facilitar la buscada extensión de la tecnología, se ha focalizado en las tecnologías de código abierto como la Fabricación por Hilo Fundido (FFF) y similares basadas en líquidos catalizables. Esta investigación se alinea dentro de la actividad de desarrollo de la FA en el CIM UPC, y en este ámbito concreto con la colaboración con el Hospital Sant Joan de Déu de Barcelona (HSJD). El primer bloque de la tesis incluye la descripción del estado del arte, detallando las tecnologías existentes y su aplicación al entorno médico. Se han establecido por primera vez unas bases de caracterización de los tejidos vivos – principalmente blandos – para dar apoyo a la selección de materiales que los puedan mimetizar en un proceso de FA, a efectos de mejorar la experiencia de ensayo de los cirujanos. El carácter rígido de los materiales mayoritariamente usados en impresión 3D los hace poco útiles para simular tumores y otras referencias anatómicas. De forma sucesiva, se tratan parámetros como la densidad, la viscoelasticidad, la caracterización de materiales blandos en la industria, el estudio del módulo elástico de tejidos blandos y vasos, la dureza de los mismos, y requerimientos como la esterilización de los modelos. El segundo bloque empieza explorando la impresión 3D mediante FFF. Se clasifican las variantes del proceso desde el punto de vista de la multimaterialidad, esencial para hacer modelos de ensayo quirúrgico, diferenciando entre soluciones multiboquilla y de mezcla en el cabezal. Se ha incluido el estudio de materiales (filamentos y líquidos) que serían más útiles para mimetizar tejidos blandos. Se constata como en los líquidos, en comparación con los filamentos, la complejidad del trabajo en procesos de FA es más elevada, y se determinan formas de imprimir materiales muy blandos. Para acabar, se exponen seis casos reales de colaboración con el HJSD, una selección de aquellos en los que el doctorando ha intervenido en los últimos años. El origen se encuentra en la dificultad del abordaje de operaciones de resección de tumores infantiles como el neuroblastoma, y en la iniciativa del Dr. Lucas Krauel. Finalmente, el Bloque 3 desarrolla numerosos conceptos (hasta 8), actividad completada a lo largo de los últimos cinco años con el apoyo de los medios del CIM UPC y de la actividad asociada a trabajos finales de estudios de estudiantes de la UPC, llegándose a materializar equipamientos experimentales para validarlos. La investigación amplia y sistemática al respecto hace que se esté más cerca de disponer de una solución de impresión 3D multimaterial de sobremesa. Se determina que la mejor vía de progreso es la de disponer de una pluralidad de cabezales independientes, a fin de capacitar la impresora 3D para integrar diversos conceptos estudiados, materializándose una posible solución. Para cerrar la tesis, se plantea cómo sería un equipamiento de impresión 3D para modelos de ensayo quirúrgico, a fin de servir de base para futuros desarrollos.

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45

Chu, Kai Yu y 朱凱鈺. "Chinese Translation of the Preschool Activity Card Sort and Its Examining on Validity and Reliability". Thesis, 2011. http://ndltd.ncl.edu.tw/handle/29324970883993232952.

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碩士
長庚大學
早期療育研究所
99
Introduction: Participation had played an important role in preschoolers’ life. They learned how to interact, work, and live with others through their participation in real-life situations and activities, and what they’ve learned during this time was also seen as the foundation of child development and future success. Since the new concepts for health and disability that International Classification of Functioning, Disability and Health (ICF) had bring, participation had gradually been emphasized by every professions in early intervention. And for the reason that there were few assessment tools in Taiwan, especiaaly for preschoolers, the purposes of this study were to develop an Chinese version of assessment tool for measuring participation adapted from the Preschool Activity Card Sort (PACS-C) and to examined its reliability and validity. Methods: The study was contained three steps. First, translating the　PACS based on the guidelines of cross-cultural adaptation process with the author’s authorization. Second, interviewing with 58 parents of typically developed children aged 3-6 years. The findings of the interviews and the suggestions obtained from the parents provided the basis for item revising on PACS-C. Third, examining the reliability and validity of PACS-C with 54 children with motor delay. All data was analyzed with SPSS 17.0. The tests of reliability included internal consistency, reliability, inter-rater reliability, and test-retest reliability, and the tests of validity were namely content validity, convergent validity/discriminant validity, construct validity and known group method. Result: PACS-C was finalized by well cross-culture adapation processes. Two items were added and five items were revised in PACS-C according to interviewee’s suggestion and the openions of expert committee for the cultural appropriateness in PACS-C. The results of the reliability and validity studies indicated high internal consistency (Cronbach α = 0.86), and moderate to excellent inter-rater reliability (ICC(3, 1) = 0.91 ~ 0.99, p<0.01) and test-retest reliability (ICC(3, 1) = 0.66 ~ 0.95, p<0.01) of the PACS-C. In addition, low to high correlation between the domains of PACS-C and Pediatric Evaluation of Disability Inventory　indicated convergent and discriminative validity (p<0.01) of PACS-C with PEDI. The construct validity was also supported by the correlation of subscale scores and full scale scores of PACS (p<0.01) and known group method comparing the domain scores between typically developed children and children with motor delay (p<0.05). Conclusion: The PACS-C has been developed for measuring participation for Children aged 3-6 years in Taiwan and part of its psychometric property has been established. The PACS-C is now expected to be applicable in Taiwan and could help family and interventionists to clearly understand the children’s participation and to make an explicit and comprehensive plan for early intervention based on the International Classification of Functioning, Disability and Health (ICF) model in the future.

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46

Graubart, Jonathan. "The intersection of transnational activism and soft law : how activists exploit NAFTA's labor and environmental accords /". 2002. http://www.library.wisc.edu/databases/connect/dissertations.html.

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47

You, Wan-Jing y 尤婉靜. "Chemical constituents and anti-inflammatory activity of the soft coral Lobophytum sp". Thesis, 2017. http://ndltd.ncl.edu.tw/handle/74881653715287130105.

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碩士
國立東華大學
海洋生物研究所
105
Diterpenes of the cembrane type are some of the most frequently encountered natural products in soft corals of the genus Lobophytum. Of particular interest, cembranoids have been reported to possess several kinds of biological activities, such as antitumor, antimicrobial and anti-inflammatory activities. During the course of our study on the anti-inflammatory chemical constituents from a wild-type soft coral Lobophytum sp., two new cembranoids, lobophyolide A (1) and B (2), along with five known compounds (3–7) have been isolated. The structures of these natural products were identified using NMR analyses, as well as data from mass spectroscopic methods. The in vitro anti-inflammatory effects of compounds 1, 2, 5, 6, 7 were also tested. The results showed that compounds 1, 2, 5, 6, 7 reduced IL-12 production from LPSstimulated dendritic cell. Moreover, compounds 1, 2, 5, 6, 7 reduced NO release from LPS-activated DCs. Accordingly, our data indicated that compounds1, 2, 5, 6, 7 exhibited as an outstanding lead for the development of anti-inflammatory agent.

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48

Huang, Ya-Ching y 黃雅靖. "Chemical Constituents and Anti-inflammatory Activity Studies of Formosan Soft Coral Nephthea chabrolii". Thesis, 2008. http://ndltd.ncl.edu.tw/handle/v5yxys.

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碩士
國立中山大學
海洋生物科技暨資源學系研究所
96
Soft corals belonging to the genus Nephthea have been found to be a rich source of terpenoids and steroids. Chromatographic separation of acetone and CH2Cl2/MeOH extracts of Formosan soft coral Nephthea chabrolii resulted in the isolation of thirteen new steroids, including nine 4α-methylated steroids (1−6, 8−10), three 19-oxygenated steroids (11−13), and a novel skeleton 19-norsteroid (7). The structures of these metabolites were elucidated by extensive spectral analyses and anti-inflammatory activities were measured in vitro. Compounds 1−2, 4−5, 7−11 and 13 at a concentration of 10 μM significantly reduce the levels of iNOS (inducible nitric oxide synthase ). Compounds 2, 4, 6−7 and 10−11 at a concentration of 10 μM also significantly reduce the levels of COX-2 (cyclooxygenase-2). Compounds 2, 4, 7, 10 and 11 can reduce the levels of both iNOS and COX-2. All compounds at a concentration of 10 μM did not affect the housekeeping β-actin protein expression.

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49

Mokeem, Lamia Sami. "Combined Effects of Soda Drinks and Nicotine on Streptococcus Mutans Metabolic Activity and Biofilm Activity". Thesis, 2019. http://hdl.handle.net/1805/22575.

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50

Chen, Xin-An y 陳信安. "Anti-dengue viral activity of cembrane-type diterpenoids isolated from soft coral Sinularia flexibilis". Thesis, 2014. http://ndltd.ncl.edu.tw/handle/f7g9uj.

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碩士
國立東華大學
生命科學系
102
Dengue virus (DENV), becomes one of the reemerging infectious pathogens worldwide. Currently there are still no effective vaccines or anti-viral drugs in clinical. Thus, current researches in developing vaccines and antiviral drugs against dengue infection would be an urgent issue. Marine natural products have been emerging as a new era in drug development, and this study focus on searching the natural compounds from soft coral and then evaluating their effects to inhibit dengue virus infection. Twelve marine compounds were initially screened and compounds named WS 9-5 and WS 9-7 are potent in inhibiting dengue virus infection. The cell cytotoxicity (CC50) of the two terpenoids was evaluated by MTT assay. WS 9-5 is evaluated to be around 21.3 ± 6.42 μM, and WS 9-7 is 47.6 ± 8.82 μM. Immunofluorescence staining evaluations have concluded that WS 9-5 inhibits DENV protein expression (Non-structure protein 1, NS1) with an effective concentration (EC50) of approximately 8.3 μM and its double-stranded RNA (dsRNA) expression with EC50 around 6.8 μM. In addition, compound WS9-5 and WS9-7 were also able to show their impact on DENV virus particle production in which WS 9-5 shows better inhibition rate as compared to WS 9-7. Further, WS 9-5 and WS 9-7 had no inhibitory effect on DENV replication and translation as the luciferase activity of DENV sub-genomic replicon (DENV replicon) has not been suppressed. It is well known that upregulation of innate immune molecules, such as IFN-β and NF-κB, could show an immense down-regulation of DENV infection. However, the inhibitory effects exerted by WS 9-5 and WS 9-7 did not involve the innate antiviral activities as type I interferon-β and NF-κB were not activated in promoter reporter assay. Unexpectedly, premixing WS 9-5 and WS9-7 with In order to know the inhibitory mechanism mediated by WS 9-5 and WS 9-7, pretreatment of cells with compounds 1 hr before infection show no inhibitory effect, but longer incubation for 3 or 6 hrs before infection substantially inhibits virus infection. These results indicate WS 9-5 and WS 9-7 may interfere with the early steps in virus infection. However, compounds will not affect the expression of DV receptors on host cells. Unexpectedly, premixing WS 9-5 and WS 9-7 with virus not only effectively neutralizes virus binding to Huh7 and BHK cells but also suppresses virus infection. This neutralizing activity of WS 9-5 and WS 9-7 was also demonstrated in Japanese Encephalitis Virus infection. Collectively, results suggest that the marine compounds WS 9-5 and WS 9-7 are capable of inhibiting the dengue virus infection through the reduction in attachment, entry, and uncoating, thereby affecting the following translation and replication. Hence this data demonstrate that WS 9-5 WS 9-7 are contemplated to be the effective drugs with high potency in inhibiting the dengue virus infection.

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