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Tesis sobre el tema "Adenosine A2B receptor"

Autor: Grafiati

Publicado: 10 de marzo de 2023

Última modificación: 31 de julio de 2025

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1

BARALDI, Stefania. "Design and Synthesis of New A2B Adenosine Receptor Antagonists." Doctoral thesis, Università degli studi di Ferrara, 2009. http://hdl.handle.net/11392/2388704.

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Starting from chemical structure of N-benzo-[1,3]dioxol-5-yl-2-[5-(2,6dioxo-1,3-dipropyl-2,3,6,7-tetrahydro-1H-purin-8-yl)-1-methyl-1H-pyrazol3-yloxy]-acetamide, MRE2029F20* various structural modifications were realized to afford a new series of A2B antagonists. The bioisosteric replacement of the anilide moiety with benzimidazole or quinazoline rings, the effect of the substitution of pyrazole with isoxazole moiety were investigated. Amide bond has been also replaced with the 5phenyl-1,2,4-oxadiazole nucleus on the basis of other adenosine pharmacophores reported previously. In this con

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2

Sun, Fengqiang. "Physical and functional interaction of A2B adenosine receptor with alpha-actinin-1/." View abstract or full-text, 2009. http://library.ust.hk/cgi/db/thesis.pl?BIOL%202009%20SUN.

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3

Johnston-Cox, Hillary A. "Control of vascular disease and glucose and insulin homeostasis by the A2b adenosine receptor." Thesis, Boston University, 2012. https://hdl.handle.net/2144/12433.

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Thesis (Ph.D.)--Boston University PLEASE NOTE: Boston University Libraries did not receive an Authorization To Manage form for this thesis or dissertation. It is therefore not openly accessible, though it may be available by request. If you are the author or principal advisor of this work and would like to request open access for it, please contact us at open-help@bu.edu. Thank you.<br>Cardiovascular disease remains a leading cause of mortality. Risk factors, including poor glycemic control, central obesity and dyslipidemia contribute to prothrombotic and proinflammatory states, which elevate

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Afzal, Aqeela. "Reduction in pre-retinal neovascularization by ribozymes that cleave the A2B receptor mRNA." [Gainesville, Fla.] : University of Florida, 2003. http://purl.fcla.edu/fcla/etd/UFE0000624.

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5

Carroll, Shannon H. "The role of the A2B adenosine receptor in the differentiation of mesenchymal stem cells to osteoblasts and chondrocytes: implications for bone development and fracture repair." Thesis, Boston University, 2013. https://hdl.handle.net/2144/10953.

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Thesis (Ph.D.)--Boston University<br>The development, maintenance and repair of the skeletal system are dependent on the differentiation of both chondrocytes and osteoblasts from their common progenitor, the mesenchymal stem cell (MSC). The A2B adenosine receptor (A2BAR) is a G-protein-coupled receptor that signals by increasing cAMP and/or activating phospholipase C signaling. Considering the published roles of cAMP on MSC differentiation, and our finding that the expression of the A2BAR is induced following injury, we hypothesized that ablation or activation of the A2BAR impacts the differen

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6

FANG, YING. "SIGNALING PATHWAY FROM THE A2B ADENOSINE RECEPTOR TO EXTRACELLULAR SIGNAL REGULATED KINASES (ERK1/2) IN HUMAN UMBILICAL VEIN ENDOTHELIAL CELLS (HUVEC) AND ITS ROLE IN HUVEC PROLIFERATION." University of Cincinnati / OhioLINK, 2006. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1148392082.

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7

Sorrentino, Claudia. "Role of CD73 - A2A/A2B receptors axis in cancer." Doctoral thesis, Universita degli studi di Salerno, 2018. http://hdl.handle.net/10556/3116.

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2016 - 2017<br>The adenosinergic pathway plays a critical role in cancer development and progression, as well as in drug resistance to chemotherapy and/or targeted-therapy. The goal of this PhD thesis was to investigate and fully characterize the role of CD73/adenosine A2A-A2B receptors axis in cancer, highlighting the therapeutic potential of inhibitors of the adenosinergic pathway. We firstly characterized the mechanism/s by which A2BR promotes immunosuppression and angiogenesis in tumor-bearing hosts, focusing on the role of myeloid-derived suppressor cells (MDSCs) and cancer-associa

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8

Matsumoto, João Paulo de Pontes. "Efeito modulatório da nicotina sobre o receptor de adenosina A2a em cultura de células do bulbo de ratos geneticamente hipertensos e normotensos." Universidade de São Paulo, 2008. http://www.teses.usp.br/teses/disponiveis/41/41135/tde-19022009-104148/.

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A hipertensão arterial é um problema de saúde pública no Brasil, pois aproximadamente 20 % da população adulta desenvolve hipertensão essencial, cujas causas ainda não são conhecidas. No entanto, sua gênese pode estar relacionada com disfunção nas áreas do sistema nervoso central (SNC) que regulam o sistema cardiovascular. O núcleo do trato solitário (NTS) e o bulbo ventrolateral são áreas importantes no controle neural da pressão arterial. Os receptores de adenosina A2a (rA2a) são encontrados em todo o SNC e estão relacionados com estudos terapêuticos de diversas doenças. No NTS a estimulação

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9

Gandía, Sánchez Jorge. "Oligomerización del receptor A2A de adenosina: interpretando el receptorsoma." Doctoral thesis, Universitat de Barcelona, 2013. http://hdl.handle.net/10803/134352.

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Los receptores acoplados a proteína G (GPCR) conforman la familia de receptores de membrana más grande. El numeroso y variado tipo de señales que detectan han otorgado a estos receptores un alto interés farmacológico. Además, las interacciones entre diferentes tipos de GPCR formando complejos oligoméricos dan lugar a complejos con características bioquímicas diferenciadas de los protómeros que los forman. En esta Tesis Doctoral se han estudiado diferentes aspectos derivados este tipo de interacciones, centrando estos experimentos alrededor del receptor A2A de adenosina (A2AR), un importante ne

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10

Larner, Carrie Jayne Byrom. "Selective targeting of the adenosine A2A receptor." Thesis, University of Cambridge, 2010. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.608592.

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11

Moscoso, Castro Maria 1988. "Study of the involvement of adenosine A2A receptors in the pathophysiology of schizophrenia." Doctoral thesis, Universitat Pompeu Fabra, 2016. http://hdl.handle.net/10803/565401.

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The adenosinergic system is a neuromodulatory complex acting on four receptor subtypes with varying distributions throughout the central nervous system. This system contributes to homeostasis and regulates several physiological functions including sleep, motor function, synaptic plasticity or cognition. Adenosine can exert an upstream modulation of several neurotransmitter systems, including dopamine and glutamate, both implicated in the pathophysiology of neuropsychiatric diseases and particularly in psychosis. Schizophrenia is considered a psychotic disease characterized by a chronic and deb

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12

Hedley, Diana. "Investigating agonist induced receptor conformational changes on the adenosine A2a receptor." Thesis, University of Reading, 2011. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.553235.

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G-protein coupled receptors (GPCRs) are one of the main targets for drug design. GPCR pharmaceutical research has bottlenecked on drug research, and the current assay systems are not creating therapeutic drugs from drug hits. The principal aim of this project was to establish a relationship between drug affinity (PKi) and drug intrinsic efficacy (Emax) using receptor conformational change parameters (measurements defined by fluorescence resonance energy transfer (FRET) experiments) to provide a new way of screening for the intrinsic efficacy of a drug. This project aimed to develop a drug scre

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13

Pagnussat, Natália. "O envolvimento dos receptores de adenosina A1 e A2A na memória em camundongos machos adultos." reponame:Biblioteca Digital de Teses e Dissertações da UFRGS, 2015. http://hdl.handle.net/10183/131897.

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A cafeína é o psicoestimulante mais consumido mundialmente. Sua ação farmacológica consiste em bloquear os receptores de adenosina A1 e A2A. A administração crônica de cafeína previne déficits cognitivos decorrentes da idade e em modelos experimentais da doença de Alzheimer. Esses efeitos preventivos são também observados pela administração do antagonista seletivo do receptor de adenosina A2A. Nesse trabalho investigou-se a participação dos receptores de adenosina A1 e A2A na prevenção dos déficits cognitivos induzidos por escopolamina. Também foi investigado se a manipulação dos receptores A2

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14

Niebauer, Ronald Thomas. "Engineering yeast cells for optimal expression of the human adenosine (A2a) receptor." Access to citation, abstract and download form provided by ProQuest Information and Learning Company; downloadable PDF file 4.52 Mb., 175 p, 2005. http://gateway.proquest.com/openurl?url_ver=Z39.88-2004&res_dat=xri:pqdiss&rft_val_fmt=info:ofi/fmt:kev:mtx:dissertation&rft_dat=xri:pqdiss:3181857.

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15

Bawa, Zharain. "Improving recombinant human adenosine A2A receptor production in yeast." Thesis, Aston University, 2014. http://publications.aston.ac.uk/23176/.

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Over 50% of clinically-marketed drugs target membrane proteins; in particular G protein-coupled receptors (GPCRs). GPCRs are vital to living cells, performing an active role in many processes, making them integral to drug development. In nature, GPCRs are not sufficiently abundant for research and their structural integrity is often lost during extraction from cell membranes. The objectives of this thesis were to increase recombinant yield of the GPCR, human adenosine A2A receptor (hA2AR) by investigating bioprocess conditions in large-scale Pichia pastoris and small-scale Saccharomyces cerevi

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16

Akkuzu, Selin. "The Functional Assessment Of Fluorecently Tagged Adenosine A2a And Dopamine D2 Receptors And Qualitative Analysis Of Dimerization Of Adenosine A2a And Dopamine D2 Receptor By Using Fret." Master's thesis, METU, 2013. http://etd.lib.metu.edu.tr/upload/12615474/index.pdf.

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Recently, several studies have demonstrated that G protein coupled receptors exist as homo/heterodimers or oligomers. Adenosine A2A receptors and dopamine D2 receptors are present as both homo- and heterodimer. In the GABAergic striatopallidal neurons A2AR are co- localized with D2 receptors (D2R), and establish functional A2AR-D2R heteromers, which modulates dopaminergic activity. Due to be involved in physiological processes, these receptors bear critical roles. Dopamine receptors play critical role in dopaminergic pathways in regulation of memory, food intake and psychomotor activity, etc.

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17

Halldner, Henriksson Linda. "Physiology and pathophysiology of central adenosine A1 and A2A receptors /." Stockholm, 2003. http://diss.kib.ki.se/2003/91-628-5732-0/.

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18

Robinson, Sarel Johannes. "Syntheses of chalcones and 2-aminopyrimidines and their evaluation as monoamine oxidase inhibitors and as adenosine receptor antagonists / Sarel Johannes Robinson." Thesis, North-West University, 2013. http://hdl.handle.net/10394/9534.

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Background and rationale - Parkinson’s disease is a neurodegenerative disorder characterised by reduced levels of dopamine in the brain. The cause of Parkinson's disease is still unknown; however several theories pertaining to the etiology exist. Current treatment mainly aims at dopamine replacement, with agents such as levodopa and dopamine agonists that provide patients with symptomatic relief. This relief is unfortunately only temporary as the progression of the disease is not halted. Furthermore, these therapies are associated with a range of side effects and novel approaches to the treat

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19

Wells, Lisa Anne. "The role of the adenosine A2A receptor in addictive processes." Thesis, University of Surrey, 2008. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.492974.

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To investigate adenosine-opioid-dopamine interactions in addictive processes, in vivo microdialysis and quantitative autoradiography were carried out using mice deficient in the adenosine A2A receptor (A2aR-/-).

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20

Stockenhuber, Alexander. "The role of adenosine A2A receptor signalling in cardiac fibrosis." Thesis, University of Oxford, 2015. https://ora.ox.ac.uk/objects/uuid:cfacf0d7-33c2-455f-97fe-4d5d6255a0a2.

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Myocardial fibrosis contributes to the pathogenesis of diverse forms of cardiac hypertrophy. Recent evidence suggests a crucial role for purinergic signalling in the formation of tissue fibrosis. In particular, inhibition of adenosine A2A receptors (A2AR) in animal models for hepatic and skin fibrosis resulted in a reduction of fibrosis formation. The specific hypothesis of this investigation was that myocardial stress results in increased interstitial levels of adenosine, which activate cardiac fibroblasts via adenosine A2AR. Accordingly, the specific objective of this investigation was to de

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21

Thevenin, Damien. "Roles of transmembrane domains in the folding and assembly of the adenosine A2A receptor." Access to citation, abstract and download form provided by ProQuest Information and Learning Company; downloadable PDF file, 170 p, 2007. http://proquest.umi.com/pqdweb?did=1260822171&sid=2&Fmt=2&clientId=8331&RQT=309&VName=PQD.

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22

Foschetti, Danielle Abreu. "Toxinas A e B do Clostridium difficille induzem a expressão diferencial de receptor de Adenosina em células epiteliais intestinais: papel do receptor A2B." reponame:Repositório Institucional da UFC, 2014. http://www.repositorio.ufc.br/handle/riufc/14909.

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FOSCHETTI, D. A. Toxinas A e B do Clostridium difficille induzem a expressão diferencial de receptor de Adenosina em células epiteliais intestinais: papel do receptor A2B. 2014. 160 f. Tese(Doutorado em Farmacologia) – Faculdade de Medicina, Universidade Federal do Ceará, Fortaleza, 2014.<br>Submitted by Erika Fernandes (erikaleitefernandes@gmail.com) on 2016-01-25T11:59:35Z No. of bitstreams: 1 2014_tese_dafoschetti.pdf: 5271291 bytes, checksum: 110e5955cf8edb636759d629ae0d7b60 (MD5)<br>Approved for entry into archive by Erika Fernandes(erikaleitefernandes@gmail.com) on 2016-01-25T11:59:46Z (

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23

Morató, Arús Xavier. "GPR37-ADENOSINE A2A receptor-receptor interaction as a new pharmacological target for Parkinson’s disease treatment." Doctoral thesis, Universitat de Barcelona, 2017. http://hdl.handle.net/10803/457874.

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GPR37 is an orphan GPCR that belongs to the Rodhopsin family. GPR37 is highly expressed in the Central Nervous System (CNS), while little peripheral expression has been found in humans and rodents. GPR37 is highly distributed in the brain, particularly at the cerebellum, corpus callosum, substantia nigra, striatum and hippocampus with a predominantly neuronal distribution. However, the function of this receptor in the CNS remains unknown. The interest on GPR37 biology was bolstered when it was described as a Parkin substrate. GPR37 was isolated from a human brain library in a yeast 2-hybrid sc

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24

CORCIULO, Carmen. "A2A adenosine receptor over-expression correlates with motor symptoms in Parkinson’s disease." Doctoral thesis, Università degli studi di Ferrara, 2014. http://hdl.handle.net/11392/2389037.

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25

Al-Hasani, Ream. "The involvement of adenosine A2a receptors in morphine and cocaine addiction." Thesis, University of Surrey, 2009. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.510572.

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26

SAPONARO, Giulia. "Design and Synthesis of New A2A and A3 Adenosine Receptors Antagonists." Doctoral thesis, Università degli studi di Ferrara, 2009. http://hdl.handle.net/11392/2388703.

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The aim of this work was the design and synthesis of new A2A and A3 adenosine receptors antagonists. Two different studies have been performed. The first one based on structural modifications of the pyrazolo[4,3-e][1,2,4]triazolo[1,5-c]pirimidine nucleus, reported in literature. In order to identify a new series of A2A or A3 AR antagonists and with the aim to better investigate the role of the nitrogen at the 7- position on the interaction with ARs, it was performed a synthetic strategy for the preparation of the pyrrolo[3,4-e][1,2,4]triazolo[1,5-c]pyrimidine nucleus which can be considered

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27

Voicu, Cristian, and n/a. "Electrophysiological effects in the rat basal ganglia following systemic adenosine A2A receptor stimulation and dopamine D2 receptor blockade." University of Otago. Department of Physiology, 2008. http://adt.otago.ac.nz./public/adt-NZDU20080811.155439.

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The difficulty with movement initiation, or akinesia, is a cardinal symptom of Parkinson�s disease (PD) and the loss of dopaminergic cells, affecting the function of the basal ganglia, the thalamus and the motor cortex, has long been documented. From a broader perspective, it has been proposed that akinesia is caused by impaired function in different brain areas, inside and outside the basal ganglia, operating as a �behavioural arrest control system� (Klemm, 2001). Several neurotransmitters seem to modulate the activity of this system and, contrasting the well-known effects of dopamine, the in

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28

Matsumoto, João Paulo de Pontes. "Receptor A2a de adenosina: estudo da modulação da liberação de neurotransmissores em modelo in vitro." Universidade de São Paulo, 2012. http://www.teses.usp.br/teses/disponiveis/41/41135/tde-03042013-115748/.

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A transmissão sináptica é essencial para o funcionamento do sistema nervoso. A neuromodulação permite regular esse processo de forma precisa. Um desses mecanismos modulatórios é a regulação da liberação de neurotransmissores. A adenosina é um importante modulador da transmissão sináptica. Além disso, a ativação do subtipo A2a dos receptores para adenosina está envolvida com a facilitação da liberação de neurotransmissores no sistema nervoso central. O presente trabalho teve como objetivo avaliar os efeitos modulatórios da ativação do receptor A2a de adenosina sobre a liberação de neurotransm

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29

Ribeiro, Alison. "Efeitos do canabidiol, um canabinóide derivado da Cannabis sativa, em um modelo murino de inflamação pulmonar aguda: uma avaliação imune-neuro-endocrinológica." Universidade de São Paulo, 2012. http://www.teses.usp.br/teses/disponiveis/10/10133/tde-01102012-162516/.

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O canabidiol (CBD), o principal canabinóide não psicotrópico extraído da marijuana (Cannabis sativa), é reconhecido por sua potente propriedade imunosupressora e anti-inflamatória. A injúria pulmonar aguda (ALI) é uma doença inflamatória para qual ainda não foi desenvolvida terapias específicas e a única alternativa de tratamento é meramente de suporte em UTI. Desta forma, foi proposta uma investigação sobre os efeitos anti-inflamatórios do CBD em um modelo murino de ALI, induzida pela instilação intra-nasal de LPS (lipopolissacarídeo), dentro de uma perspectiva imune-neuro-endocrinológica. Pa

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30

Jardim, Fernanda Rafaela. "Ação da adenosina extracelular sobre uma linhagem de célula estrelada hepática tratada com TNF-[alfa] : papel do receptor A2B." reponame:Biblioteca Digital de Teses e Dissertações da UFRGS, 2008. http://hdl.handle.net/10183/14831.

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Fibrose hepática é caracterizada pelo acúmulo de matriz extracelular fibrótica, cuja presença danifica as funções do fígado. Células estreladas hepáticas (HSCs) participam ativamente deste processo, modificando seu fenótipo quiescente, rico em lipídios no citoplasma, para o fenótipo ativado, em resposta ao insulto fibrogênico. A regressão do processo fibrótico pode, inclusive, estar relacionada com a apoptose das HSCs e também com sua reversão fenotípica, do estado ativado ao estado quiescente. Adenosina tem papel hepatoprotetor bem conhecido e medeia várias ações antiinflamatórias em diferent

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31

Aguiar, Lissiana Magna Vasconcelos. "Antagonismo do receptor da adenosina A2a: Nova perspectiva para o tratamento da doenÃa de Parkinson." Universidade Federal do CearÃ, 2009. http://www.teses.ufc.br/tde_busca/arquivo.php?codArquivo=3047.

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Conselho Nacional de Desenvolvimento CientÃfico e TecnolÃgico<br>A doenÃa de Parkinson (DP) Ã uma desordem neurodegenerativa, caracterizada pela destruiÃÃo dos neurÃnios nigroestriatais dopaminÃrgicos. O tratamento atual para esta doenÃa estÃ restrito ao alÃvio sintomÃtico, porque atÃ o presente momento nÃo existem agentes capazes de inibir a degeneraÃÃo neuronal. Existem evidÃncias experimentais de que antagonistas de receptores A2A da adenosina poderiam ser Ãteis no tratamento de DP. Com a finalidade de investigar essa possibilidade, o presente trabalho demonstrou os efeitos da cafeÃna e do

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32

Cavalcante, Ingrid Chaves. "Study of a new adenosine receptor A2A agonist, ATL313, on Clostridium difficile toxin A-induced enteritis in ileal pouch isolated of mice." Universidade Federal do CearÃ, 2005. http://www.teses.ufc.br/tde_busca/arquivo.php?codArquivo=84.

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Conselho Nacional de Desenvolvimento CientÃfico e TecnolÃgico<br>C. difficile toxin A (TxA) plays an important pathogenic role in antibiotic-induced diarrhea and pseudomembranous colitis, a condition characterized by intense mucosal inflammation and secretion. Agonist activity at A2A adenosine receptors (A2A ARs) attenuates inflammation and damage in many tissues. This study evaluated the effect of a new selective A2A AR agonist (4-{3-[6-amino-9-(5-cyclopropylcarbamoyl-3,4-dihydroxytetrahydrofuran-2-yl)-9H-purin-2-yl]prop-2-ynyl}piperidine-1-carboxylic acid methyl ester; ATL313) on TxA-induced

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Stumpf, Anette D. [Verfasser], and Carsten [Gutachter] Hoffmann. "Development of fluorescent FRET receptor sensors for investigation of conformational changes in adenosine A1 and A2A receptors / Anette D. Stumpf. Gutachter: Carsten Hoffmann." Würzburg : Universität Würzburg, 2016. http://d-nb.info/1111887357/34.

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Foschetti, Danielle Abreu. "Toxinas A e B do Clostridium difficille induzem a expressÃo diferencial de receptor de Adenosina em cÃlulas epiteliais intestinais: papel do receptor A2B." Universidade Federal do CearÃ, 2014. http://www.teses.ufc.br/tde_busca/arquivo.php?codArquivo=15833.

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nÃo hÃ<br>O Clostridium difficile Ã reconhecido por ser uma bactÃria nosocomial, levando a intensa inflamaÃÃo intestinal, quebra da barreira epitelial e diarreia. A produÃÃo de adenosina estÃ aumenta durante eventos inflamatÃrios. O receptor de adenosina A2B (A2BR) Ã o mais expresso no intestino de humanos e camundongos. NÃs investigamos o efeito de exposiÃÃo Ãs TcdA e TcdB, a curto e longo prazo, em cÃlulas HCT-8 e cÃlulas epiteliais intestinais isoladas do ceco. CÃlulas HCT-8 foram expostas a TcdA ou TcdB (10 ng/ml) por 2, 6 e 24h. Foi usado o modelo de alÃa cecal e de infecÃÃo pelo bacilo e

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Milne, Gillian R. "The A2A adenosine receptor : its role in suppressing vascular inflammation and its regulation by phosphorylation." Thesis, University of Glasgow, 2009. http://theses.gla.ac.uk/537/.

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Endothelial inflammation leading to vascular dysfunction is a major contributor to the development of atherosclerosis. The release of adenosine at sites of inflammation represents an endogenous mechanism for limiting excessive inflammation and tissue damage. The majority of the anti-inflammatory effects of adenosine are mediated by signalling through the A2AAR and activation of the A2AAR has been shown to be protective in numerous models of inflammatory disease. Little is known about the molecular mechanisms behind these effects. However, in vitro studies using cultured endothelial cells indic

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BETTI, MARCO. "Design, synthesis and pharmacological evaluation of new adenosine receptor ligands." Doctoral thesis, 2017. http://hdl.handle.net/2158/1076744.

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The research reported in this Ph.D. thesis, though it has to be deepened, furthers our understanding about the ARs. New AR ligands were developed preferentially belonging to the aminopyridine-3,5-dicarbonitrile series whose structure-activity relationships have been till now poorly investigated. In fact, most of the compounds reported in the literature are included in patent documents. In this work, many derivatives were synthesized and biologically evaluated in binding and functional assays in order to assess affinity and selectivity towards a specific AR subtype, but also to evaluate their p

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Dettori, Ilaria. "Protection by adenosinergic and histaminergic drugs from ischemic damage induced by middle cerebral artery occlusion in the rat." Doctoral thesis, 2019. http://hdl.handle.net/2158/1151849.

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Cerebral ischemia is a multifactorial pathology characterized by different events evolving in time. The acute injury, characterized by a massive increase of extracellular glutamate levels, is followed by activation of resident immune cells and production or activation of inflammation mediators. Although after ischemia precocious activation of immune cells may be neuroprotective and supportive for regeneration, protracted neuroinflammation is now recognized as the predominant mechanism of secondary brain injury progression. In this thesis I investigated on the putative protective effects of lig

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Ciocca, Caroline. "A2B adenosine receptor modulation of TNF-alpha expression in mouse rheumatoid arthritis." Thesis, 2017. https://hdl.handle.net/2144/23774.

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Rheumatoid arthritis (RA) is a chronic inflammatory autoimmune disease that leads to destruction of articular cartilage and subchondral bone at the synovial joints. Clinically, RA is characterized by swelling, tenderness and destruction of synovial joints, which results in severe disability and premature mortality. In the RA disease state, inflammation in the synovial compartment is regulated by a complex cytokine and chemokine network, including tumor necrosis factor α (TNFα), which has been clinically demonstrated a key mediator of RA pathogenesis. TNFα can be found in elevated levels in the

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Gonçalves, Mafalda Bessa Martins. "Targeting the adenosine A2B receptor may attenuate cardiac remodelling secondary to pulmonary hypertension." Master's thesis, 2015. http://hdl.handle.net/10348/5556.

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Dissertação de Mestrado em Genética Molecular Comparativa e Tecnológica<br>A Hipertensão Arterial Pulmonar (HAP) é uma doença complexa e multifactorial que induz uma sobrecarga no coração, devido ao aumento da resistência da circulação pulmonar. Neste cenário de aumento de resistência da circulação pulmonar, o lado direito do coração fica sobrecarregado, conduzindo à remodelação tissular do miocárdio e, eventualmente, falência do ventrículo direito (VD). A adenosina (ADO) é uma molécula de sinalização que é ubíqua e capaz de modular a função cardíaca mediante a interação com vários subtip

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Eisenstein, Anna. "The role of the A2B adenosine receptor in adipogenesis and in obesity-induced type 2 diabetes mellitus." Thesis, 2016. https://hdl.handle.net/2144/15255.

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Obesity is a significant health care problem, affecting more than one third of the United States population and is an important risk factor for Type 2 Diabetes Mellitus (T2D). Adipose tissue expansion results in the recruitment and accumulation of macrophages, which secrete proinflammatory cytokines that impair insulin signaling. Adenosine regulates inflammation by signaling through G-protein coupled receptors (GPCRs), such as the A2b adenosine receptor (A2bAR). Recently a role for adenosine receptors has been described in the differentiation of osteoblasts and adipocytes. This thesis tests t

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Dias, Eduardo Ferreira Martins. "Changes in Gene Expression and Adenosine A2B Receptor Activity in the Failing Right Ventricle Secondary to Pulmonary Arterial Hypertension." Master's thesis, 2018. http://hdl.handle.net/10348/8620.

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A hipertensão arterial pulmonar (HAP) é uma doença progressiva e potencialmente fatal que afeta a vasculatura pulmonar e, consequentemente, o coração. Esta doença cardiopulmonar é caracterizada por uma ampla variedade de fatores desencadeadores iniciais que promovem a remodelação da vasculatura pulmonar, aumentando a sua resistência ao fluxo sanguíneo. Este estado de elevada resistência circulatória pulmonar sobrecarrega o ventrículo direito (VD). A sobrecarga contínua exercida pelo incremento da pressão da artéria pulmonar é agravada pelo aumento da massa muscular (remodelação do VD) no senti

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Irene, Fusco. "Effects of adenosine A2B and A3 receptor ligands on synaptic activity, oligodendrogenesis and dorsal root ganglia excitability in vitro." Doctoral thesis, 2019. http://hdl.handle.net/2158/1150362.

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Selim, Farag Farouk Sherbiny [Verfasser]. "The human adenosine A2B receptor : homology modeling, virtual screening, and computer-aided drug design / vorgelegt von Farag Farouk Sherbiny Selim." 2011. http://d-nb.info/1013296567/34.

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Henriques, Ana Margarida Cardoso. "Modulation of NMDA receptor currents by adenosine A2A receptors in the Schaffer collaterals-CA1 synapses." Master's thesis, 2017. http://hdl.handle.net/10316/83240.

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Dissertação de Mestrado em Biologia Celular e Molecular apresentada à Faculdade de Ciências e Tecnologia<br>Adenosine is a neuromodulator able to control the balance between neuronal excitation and inhibition, throughout the central nervous system (CNS). Adenosine acts onto a G protein–coupled receptors (GPCRs) subfamily called P1 adenosine receptors: A1R, A2AR, A2BR and A3R. Adenosine type 2A receptor (A2AR) is highly expressed in striatum, whereas in other brain regions A2AR is expressed at lower levels. One of these regions is the hippocampus, a central brain region enrolled in learning an

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Świrski, Mateusz. "Synteza innowacyjnych małocząsteczkowych modulatorów immunosupresyjnego szlaku adenozyny." Praca doktorska, 2022. https://ruj.uj.edu.pl/xmlui/handle/item/289708.

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Amaral, Ana Carolina Palmeira do. "Illuminating G protein-coupled receptors: a bioluminescence-based method to photoactivate receptor ligands." Master's thesis, 2019. http://hdl.handle.net/10316/88003.

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Dissertação de Mestrado em Bioquímica apresentada à Faculdade de Ciências e Tecnologia<br>Recetores acoplados à proteína G são alvos terapêuticos-chave para muitas condições patológicas. Estudos demonstraram que os recetores A2A de adenosina (A2AR) e D2 de dopamina (D2R) acoplados à proteína G formam heterómeros A2AR-D2R no estriado. A estequiometria deste heterómero encontra-se alterada na doença de Parkinson (DP) e a sinalização mediada pelos recetores A2A pode ser promovida. Deste modo, os recetores A2A são o alvo farmacológico de eleição na DP que mais tem recebido atenção nos últimos ano

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Mouro, Francisco Melo Albuquerque Saraiva 1988. "Modulation of NMDA receptor activity through adenosine A2A receptors in the hippocampus." Master's thesis, 2012. http://hdl.handle.net/10451/7431.

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Tese de mestrado. Biologia (Biologia Humana e Ambiente). Universidade de Lisboa, Faculdade de Ciências, 2012<br>O hipocampo é a estrutura cerebral mais estudada na investigação neurocientífica. A subdivisão CA1 do hipocampo contém a população neuronal que apresenta menor heterogeneidade entre neurónios, encontrando-se organizada em camadas bem definidas, o que torna os neurónios fáceis de identificar e de estudar (Szilágyi et al. 2011). O neurónio é a unidade sinalizadora individual do sistema nervoso central (SNC). Os neurónios estão inseridos numa complexa rede de circuitos neuronais que se

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Svobodová, Magdaléna. "Mikroglie kontrolují astrogliózu zprostředkovanou adenosinovými A2A-receptory." Master's thesis, 2017. http://www.nusl.cz/ntk/nusl-370979.

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Charles University Faculty of Pharmacy in Hradec Králové Department of Pharmacology and Toxicology Candidate: Magdaléna Svobodová Supervisor: Assoc. Prof. Přemysl Mladěnka, Ph.D. Assoc. Prof. Maria da Glória Correia da Silva Queiroz, Ph.D. Title of diploma thesis: Microglia control adenosine A2A-receptor mediated astrogliosis In the central nervous system, astrocytes and microglia are the main cells coordinating the inflammatory response. During inflammation, dying or temporarily damaged cells release ATP, as a danger-associated signal molecule, that contributes to the induction of astrogliosi

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Henriques, Vanessa Jorge. "Astrocytic A2A receptors : novel targets to manage brain disorders." Master's thesis, 2016. http://hdl.handle.net/10316/41013.

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Dissertação de mestrado em Investigação Biomédica, apresentada à Faculdade de Medicina da Universidade de Coimbra<br>Adenosine is a prototypic modulator of synaptic transmission in the CNS; it mainly controls excitatory transmission through a coordinated action of inhibitory A1 receptors and facilitatory adenosine A2A receptors (A1R, A2AR) and, albeit their physiological and pathological role have mainly been assumed to result from their direct action on neurons, they are also present in astrocytes where they control astrogliosis, proliferation, cell death, and the release of neurotrophic

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Chien, Chen-li, and 簡禎利. "Characterization of the Rat A2A Adenosine Receptor Gene." Thesis, 2001. http://ndltd.ncl.edu.tw/handle/86892298259924920964.

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碩士<br>國立陽明大學<br>神經科學研究所<br>89<br>The rat A2A adenosine receptor (A2A-R) is heavily enriched in the striatum and is also expressed at relatively low levels in other areas of the brain. Gene of A2A-R contains two independent promoters (P1 and P2). Transcripts produced from these two promoters differ in the length of their 5'-untranslated regions (5'-UTR), but encode the same protein. To further characterize the transcriptional regulation of the A2A-R gene in vivo, a fusion gene consisting the 4.8 kb 5'-flanking region / full length 5'UTR of the A2A-R gene and the coding region of the N-lacZ (n-β

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