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Tesis sobre el tema "Adipose-derived stem cells, regenerative medicine"

Autor: Grafiati

Publicado: 11 de marzo de 2023

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1

Srivastava, Sapna. "The potential of human adipose derived stem cells for myocardial regenerative therapy." Thesis, McGill University, 2010. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=95088.

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Background: Cell therapy using Human Bone Marrow Stem Cells (HBMSCs) has been shown to improve heart function after a myocardial infarction. The harvesting technique involved with bone marrow stem cells is invasive and yields a low cell number. There is now an increasing interest in Human Adipose Derived Stem Cells (HADSCs) as they are abundant and readily accessible from liposuction material. The present study was undertaken to investigate if HADSCs are superior than HBMSCs in myocardial regenerative therapy. Results: Both HADSCs and HBMSCs proliferated in a time dependent manner, however, t

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Francis, Michael. "RECAPITULATING OSTEOBLASTOGENESIS WITH ELECTROSPUN FIBRINOGEN NANOFIBERS AND ADIPOSE STEM CELLS AND ELECTROSPINNING ADIPOSE TISSUE-DERIVED BASEMENT MEMBRANE." VCU Scholars Compass, 2010. http://scholarscompass.vcu.edu/etd/2025.

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To repair, replace, or regenerate damaged or diseased tissue has been a long-standing, albeit elusive, goal in medical research. Here, we characterize patient-derivable mesenchymal stem cell types, termed adipose-derived stem cells (ASCs). These cells, which can be derived from liposuction fat and lipoaspirate saline, are sources for patient-derivable extracellular matrix (ECM), fibrinogen (Fg) and adipose tissue extracellular matrix, and may prove useful for synthesizing new bone tissue analogues in vitro. Traditionally and rapidly isolated ASCs were thoroughly characterized as multipotent,

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3

Sutha, Ken. "Osteoinductive material derived from differentiating embryonic stem cells." Diss., Georgia Institute of Technology, 2012. http://hdl.handle.net/1853/51722.

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The loss of regenerative capacity of bone, from fetal to adult to aged animals, has been attributed not only to a decline in the function of cells involved in bone formation but also to alterations in the bone microenvironment that occur through development and aging, including extracellular matrix (ECM) composition and growth/trophic factor content. In the development of novel treatments for bone repair, one potential therapeutic goal is the restoration of a more regenerative microenvironment, as found during embryonic development. One approach to creating such a microenvironment is through t

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4

Lazin, Jamie Jonas. "The effect of age and sex on the number and osteogenic differentiation potential of adipose-derived mesenchymal stem cells." Thesis, Georgia Institute of Technology, 2010. http://hdl.handle.net/1853/34696.

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It has been shown that stem cells exist within adult adipose tissue. These stem cells are named adipose-derived mesenchymal stem cells (ASCs), are derived from the mesoderm, and can differentiate into a number of cells including osteoblasts, chondrocytes, and adipocytes. However, before these cells can be used clinically it is important that we understand how factors like age, sex, and ethnicity affect ASC number and potential. Additionally, since men and women vary in their distribution of adipose tissue, it will be important to see if the ideal source of ASCs is different for each sex. The

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5

Nair, Rekha. "Acellular matrices derived from differentiating embryonic stem cells." Diss., Georgia Institute of Technology, 2009. http://hdl.handle.net/1853/37170.

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Embryonic stem cells (ESCs) can differentiate into all somatic cells, and as such, are a promising cell source for therapeutic applications. In vitro, ESCs spontaneously differentiate via the aggregation of cells into embryoid bodies (EBs), which recapitulate aspects of early embryogenesis and harbor a unique reservoir of cues critical for tissue formation and morphogenesis. Embryonic healing responses employ similar intrinsic machinery used for tissue development, and these morphogenic cues may be captured within the EB microenvironment. Recent studies have shown that when injected into in

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6

Yasin, Mohammed. "Non-regenerative benefits of adult bone marrow derived stem cells for myocardial protection." Thesis, Queen Mary, University of London, 2013. http://qmro.qmul.ac.uk/xmlui/handle/123456789/8701.

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Ischaemic heart disease is the most common cause of mortality in the western hemisphere and it is rapidly becoming the leading cause of death globally. Moreover, therapeutic interventions by cardiologists and cardiac surgeons frequently subject the heart to acute I/R injury, which in itself can cause mortality. Recent investigations of adult stem cells have primarily focused on their regenerative potential for chronic ischaemic heart disease. In this thesis, I have investigated the hypothesis that adult bone marrow derived stem cells are cardioprotective in acute regional myocardial I/R injury

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7

Arrigoni, E. "ADIPOSE-DERIVED STEM CELLS (ASCS) FOR FUTURE CELLULAR THERAPIES IN MUSCLE-SKELETAL TISSUES REGENERATION." Doctoral thesis, Università degli Studi di Milano, 2012. http://hdl.handle.net/2434/170261.

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Every year several patients have to deal with bone tissue loss due to trauma or diseases. Bone tissue engineering aims to restore or repair musculoskeletal disorders through the development of bio-substitutes that require the use of cells and scaffolds which should possess both adequate mechanical properties and interconnecting pores to allow cellular infiltration, graft integration and vascularization. The ideal cell for tissue engineering should possess a potential plasticity with the ability to functionally repair the damaged tissue, and it should be available in large amount. Mesenchymal s

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8

GRILLI, FEDERICA. "Controlling the Adipose-derived Stem cell 3D-organization on micrometric PLGA regular scaffolds for cardiac tissue regeneration and repair." Doctoral thesis, Università degli studi di Genova, 2022. http://hdl.handle.net/11567/1091894.

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The deposition of cells at sites of injury is a clinically relevant approach to facilitate local tissue regeneration and repair. However, cell engraftment, retention, and survival are generally modest, requiring the development of novel deposition techniques and biomaterials. Here, a micro-sized polymeric network (microMESH) is investigated as a promising biodegradable scaffold for the engraftment and tissue integration of human Adipose-Derived Stem Cells (hADSCs) to be used for a wide range of injuries, including myocardial infarction. microMESH comprises a regular network of PLGA microfilame

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9

Caremoli, F. "PURIFICATION, CHARACTERIZATION AND CULTURE OF ENSHEATHING CELLS FROM HUMAN OLFACTORY MUCOSA BIOPSIES." Doctoral thesis, Università degli Studi di Milano, 2015. http://hdl.handle.net/2434/335140.

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Among all the possible sources of mesenchymal stem cells, adipose tissue and olfactory mucosa have raised great interest and have become some of the most investigated sources. Adipose tissue-derived mesenchymal stem cells and the fat itself as a source of human adipose derived stem cells, represent one of the major fields of research in regenerative medicine. A great advantage is represented by the minimal invasive and high accessibility to adipose tissue and its ready availability. In the present study, hADSCs were isolated from the adipose tissue donated by several patient and have been in

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10

Sunohara, Tadashi. "MicroRNA-based separation of cortico-fugal projection neuron-like cells derived from embryonic stem cells." Kyoto University, 2020. http://hdl.handle.net/2433/253176.

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11

Perrini, C. "EQUINE AND BOVINE MICROVESICLES DERIVED FROM AMNIOTIC PROGENITOR CELLS IN REGENERATIVE AND REPRODUCTIVE TOPICS." Doctoral thesis, Università degli Studi di Milano, 2017. http://hdl.handle.net/2434/490022.

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Durante questo progetto di dottorato sono stati condotti studi per comprendere la capacità delle cellule mesenchimali amniotiche (AMCs) di agire attraverso meccanismi paracrini. La prima fase del disegno sperimentale ha valutato l’efficacia delle AMCs sulla proliferazione delle cellule endometriali (EDCs) in assenza di un contatto cellula-cellula. Le EDCs sono state co-coltivate in un sistema trans-well con le AMCs o sono state coltivate in presenza del loro medium condizionato (CM). In entrambe le condizioni sperimentali è stato osservato un aumento del tasso di proliferazione delle EDCs defi

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12

Hackett, Simon Marc. "Addressing the immunological barriers to regenerative medicine : differentiation and characterisation of dendritic cells derived from induced pluripotent stem cells." Thesis, University of Oxford, 2013. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.644988.

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Induced pluripotent stem cells (iPS cells) have shown great promise in the newly-developing field . of regenerative medicine. Recently, however; there have been conflicting reports regarding their immunogenicity, even when derived in an autologous fashion, due to the ectopic expression of certain developmental antigens. Dendritic cells (DC) are professional antigen presenting cells and therefore serve as potential tools for modulating the immune response, particularly with respect to acceptance of stem cell-derived tissues. We hypothesised that DC differentiated from iPS cells, so-called iPS,

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13

Bargehr, Johannes. "The role of human embryonic stem cell-derived epicardium in myocardial graft development." Thesis, University of Cambridge, 2018. https://www.repository.cam.ac.uk/handle/1810/276112.

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14

Nakane, Takeichiro. "Impact of Cell Composition and Geometry on Human Induced Pluripotent Stem Cells-Derived Engineered Cardiac Tissue." Kyoto University, 2018. http://hdl.handle.net/2433/232090.

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15

Bogers, Sophie Helen. "Turning Round: Optimizing the Anti-Inflammatory Properties of Equine Bone Marrow Derived Mesenchymal Stem Cells for Osteoarthritis Through Three-Dimensional Culture." Diss., Virginia Tech, 2017. http://hdl.handle.net/10919/81746.

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Osteoarthritis (OA) is a degenerative disease of diarthrodial joints causing pain and loss of joint function. Etiology is heterogeneous, but commonly involves inflammation arising from impairment of normal tissue homeostasis and/or function. A cycle of low-grade inflammation and global tissue degradation causes alteration of tissue morphology and function via primary mechanisms or inability to withstand physiological forces. Current therapies variably ameliorate symptoms but do not modify progression. Mesenchymal stem cells (MSCs) have multi-modal properties but are ineffective in ameliorating

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16

Ahmad, Faizzan Syed. "A novel human stem cell platform for probing adrenoceptor signaling in iPSC derived cardiomyocytes including those with an adult atrial phenotype." Thesis, University of Oxford, 2017. http://ora.ox.ac.uk/objects/uuid:17972018-6750-4e5c-8cc9-42e9c381f531.

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Scientific research is propelled by two objectives: Understanding and recognizing the essential biology of life, and deciphering this to uncover possible therapeutics in order to improve quality of life as well as relieve pain from disease. The aim of the work described in this thesis was to dissect the fundamental requirements of induced pluripotent stem cells both in pluripotency and differentiation with a particular focus on atrial specificity. Drug targeting of atrial-specific ion channels has been difficult because of lack of availability of appropriate cardiac cells, and preclinical test

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17

Spitzhorn, Lucas-Sebastian [Verfasser], and James [Gutachter] Adjaye. "Derivation, characterization and application of human primary stem cells, iPSCs, and iPSC-derived MSCs for regenerative medicine and disease modelling / Lucas-Sebastian Spitzhorn ; Gutachter: James Adjaye." Düsseldorf : Universitäts- und Landesbibliothek der Heinrich-Heine-Universität Düsseldorf, 2020. http://d-nb.info/1203369867/34.

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Kaur, Navdeep. "Influence of culture conditions on the molecular signature of mesenchymal stem cells." Thesis, Queensland University of Technology, 2010. https://eprints.qut.edu.au/43719/1/Navdeep_Kaur_Thesis.pdf.

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Cell based therapies require cells capable of self renewal and differentiation, and a prerequisite is the ability to prepare an effective dose of ex vivo expanded cells for autologous transplants. The in vivo identification of a source of physiologically relevant cell types suitable for cell therapies is therefore an integral part of tissue engineering. Bone marrow is the most easily accessible source of mesenchymal stem cells (MSCs), and harbours two distinct populations of adult stem cells; namely hematopoietic stem cells (HSCs) and bone mesenchymal stem cells (BMSCs). Unlike HSCs, there ar

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19

Rony, R. M. Imtiaz Karim. "Transcriptional characterization of osteogenic and adipogenic differentiation of human bone marrow derived mesenchymal stem cells in 2D and 3D peptide hydrogel culture system." Wright State University / OhioLINK, 2018. http://rave.ohiolink.edu/etdc/view?acc_num=wright1536841298659517.

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Mojallal, Ali. "Le tissu adipeux et ses cellules souches en chirurgie plastique et en ingénierie tissulaire : les conditions de prélèvement, de culture et de greffe." Thesis, Lyon 1, 2010. http://www.theses.fr/2010LYO10158.

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Les premières utilisations du tissu adipeux comme produit de comblement en chirurgie plastique remontent à la fin du 19ème siècle. Depuis quelques décennies, la greffe de tissu adipeux a bénéficié d'un regain d'intérêt utilisant un procédé chirurgical rigoureux. Devant la démonstration de la survie cellulaire et les bons résultats cliniques obtenus, l'utilisation de cette technique s'est élargie à tous les domaines de la chirurgie plastique. Cette technique est simple et efficace et représente actuellement le meilleur moyen de restaurer les défauts de contours et de volume. Récemment, de nouve

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21

Bertoni, Lélia. "Évaluation du potentiel thérapeutique des cellules souches mésenchymateuses dans un modèle d'arthropathie expérimentale induite chez le cheval Characterization and use of Equine Bone Marrow Mesenchymal Stem Cells in Equine Cartilage Engineering. Study of their Hyaline Cartilage Forming Potential when Cultured under Hypoxia within a Biomaterial in the Presence of BMP-2 and TGF-ß1 Intra-Articular Injection of 2 Different Dosages of Autologous and Allogeneic Bone Marrow- and Umbilical Cord-Derived Mesenchymal Stem Cells Triggers a Variable Inflammatory Response of the Fetlock Joint on 12 Sound Experimental Horses An experimentally induced osteoarthritis model in horses performed on both metacarpophalangeal and metatarsophalangeal joints: Technical, clinical, imaging, biochemical, macroscopic and microscopic characterization Evaluation of allogeneic bone-marrow-derived and umbilical cord blood-derived mesenchymal stem cells to prevent the development of osteoarthritis in an equine model Chondrogenic Differentiation of Defined Equine Mesenchymal Stem Cells Derived from Umbilical Cord Blood for Use in Cartilage Repair Therapy." Thesis, Normandie, 2020. http://www.theses.fr/2020NORMC417.

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’arthropathie dégénérative est une maladie ayant des répercussions socio-économiques majeures chez l’homme et le cheval. Il n’existe pour l’heure aucun traitement curatif de cette maladie, le cartilage articulaire étant dépourvu de pouvoir de cicatrisation spontané. De nombreux espoirs reposent sur l’utilisation de cellules souches mésenchymateuses (CSM), pour leur potentiel pro-régénératif et anti-inflammatoire. Le premier objectif de cette étude était d’évaluer la tolérance des CSM de sang de cordon ombilical (SCO) et de moelle osseuse (MO) dans des articulations saines. L’étude contrôlée en

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22

Norris, Caroline Elizabeth. "Pericardial adipose tissue stem cell expansion and characterisation for regenerative medicine applications." Thesis, University of Bristol, 2017. https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.752732.

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Girard, Anne-Claire. "Thérapies à partir du tissu adipeux : de la chirurgie esthétique et reconstructrice à la thérapie cellulaire. Application à la régénération des tendons chez les chevaux." Thesis, La Réunion, 2012. http://www.theses.fr/2012LARE0034/document.

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Utilisée depuis plus d'un siècle en chirurgie esthétique, la greffe autologue de tissu adipeux, ou lipofilling, est une technique sûre permettant le comblement des tissus mous. Cependant, bien que la technique ait connue de nettes améliorations au cours du temps, les chirurgiens font toujours face à une résorption du greffon qui oblige dans la majorité des cas à planifier plusieurs autres interventions afin que le résultat esthétique soit en adéquation avec les attentes du patient. Le procédé MICROFILL® a été développé dans le but d'augmenter le taux de prise de greffe en favorisant la survie

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Di, Summa Pietro Giovanni. "Schwann cell-like differentiated adipose-derived stem cells : in vivo applications and future perspectives for nerve regeneration." Thesis, University of Manchester, 2012. https://www.research.manchester.ac.uk/portal/en/theses/schwann-celllike-differentiatedadiposederived-stem-cellsin-vivo-applications-and-futureperspectives-for-nerve-regeneration(cce4ab09-f58b-48c6-9372-5efcb1127e1a).html.

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Traumatic injuries resulting in peripheral nerve lesions often require a graft to bridge the gap. Although autologous nerve graft is still the first choice strategy in reconstructions, it has the severe disadvantage of the sacrifice of a functional nerve. Cell transplantation in a bioartificial conduit is an alternative strategy to create a favourable environment for nerve regeneration. Among adult stem cells, adipose-derived stem cells (ASC) are a useful tool in regenerative medicine as they can be induced towards multiple mesodermal and nonmesodermal lineages, being recently differentiated i

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Upchurch, David A. "Administration of adipose-derived stromal vascular fraction and platelet rich plasma in dogs with coxofemoral osteoarthritis." Thesis, Kansas State University, 2015. http://hdl.handle.net/2097/19769.

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Master of Science<br>Department of Clinical Sciences<br>Walter Renberg<br>Objective: To evaluate the safety and effect of a single simultaneous intra-articular and intravenous injection of autologous adipose-derived stromal vascular fraction (SVF) and platelet rich plasma (PRP) on coxofemoral osteoarthritis (OA) in dogs. Methods: This was a randomized, double-blind, placebo-controlled prospective pilot trial of simultaneous intra-articular and intravenous SVF and PRP for coxofemoral OA. Dogs with coxofemoral OA causing signs of lameness or discomfort were evaluated by orthopedic exam, visua

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26

Ūsas, Arvydas. "Regeneration of injured bone and articular cartilage using mouse muscle derived stem cells." Doctoral thesis, Lithuanian Academic Libraries Network (LABT), 2011. http://vddb.laba.lt/obj/LT-eLABa-0001:E.02~2011~D_20110428_084507-21298.

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The objective of the study: To characterize stem cells isolated from mouse skeletal muscle and evaluate their regenerative potential to repair injured bone and articular cartilage in a mouse and rat animal model. The aims of the study: 1. Isolate MDSCs from mouse skeletal muscle, to determine their phenotypic characteristics and differentiation potential in vitro. 2. Evaluate osteogenic and chondrogenic regeneration capacity of MDSCs genetically engineered to express bone morphogenetic protein 4 (BMP4). 3. Evaluate osteogenic and chondrogenic differentiation potential of MDSCs-expressing BMP4

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27

Seria, Elisa Libera. "Rigenerazione epatica mediante l'impiego di cellule staminali mesenchimali in un modello murino di danno epatico tetracloruro-indotto." Doctoral thesis, Università di Catania, 2012. http://hdl.handle.net/10761/1133.

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Bone marrow-derived mesenchymal stem cells (MSCs) have been investigated as marker of liver regeneration in an experimental model of acute liver failure (ALF). This model was created in Wistar rats through an intraperitoneal injection of carbon tetrachloride (CCl4). MSCs (3 million) were collected by long bones of 10 Wistar rats and then intravenously infused 24 hours after induction of ALF in 16 rats, Group A. In control Group B, 16 rats received a peritoneal injection of CCl4, and an intravenous infusion of normal saline. All rats were sacrificed at 2, 3, 4 and 7 days post-CCl4-injection. To

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28

PERBELLINI, Filippo. "Adipose and cardiac progenitor cells for regenerative medicine." Doctoral thesis, 2014. http://hdl.handle.net/11562/694159.

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Le malattie cardiovascolari e il loro evoluzione in arresto cardiaco, sono una della principali cause di morte a livello mondiale. Il diabete è spesso associato all'alterazione dei substrati metabolici i quali sono in grado di modificare l'omeostasi dei tessuti ed alterare le popolazioni di precursori cellulari. La maggior parte dei tessuti adulti presenta delle sotto-popolazioni di progenitori mesenchimali che, a causa delle loro proprietà rigenerative, sono un'interessante fonte di cellule per la medicina rigenerativa e la terapia cellulare. Recentemente è stato dimostrato che, in seguito ad

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29

Lee, Justin J. "Development of Delivery Strategy for Adipose-Derived Stem Cells in the Treatment of Myocardial Infarction." Thesis, 2012. http://hdl.handle.net/1974/7620.

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Cell-based therapies involving adipose-derived stem cells (ASCs) have shown promise in stimulating cardiovascular regeneration, including in the treatment of myocardial infarction (MI) and ischemic heart disease. However, previous studies involving the delivery of ASCs following MI have indicated that therapeutic efficacy has been limited by low survival and/or poor retention of the transplanted cells at the site of injury. To address these limitations, the goal of this thesis was to develop a more effective delivery strategy incorporating an injectable biomaterial combined with chemotactic gr

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30

Trevor, Lucy V., Kirsten Riches-Suman, A. L. Mahajan, and M. Julie Thornton. "Adipose tissue: a source of stem cells with potential for regenerative therapies for wound healing." 2020. http://hdl.handle.net/10454/18436.

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Yes<br>Interest in adipose tissue is fast becoming a focus of research after many years of being considered as a simple connective tissue. It is becoming increasingly apparent that adipose tissue contains a number of diverse cell types, including adipose-derived stem cells (ASCs) with the potential to differentiate into a number of cell lineages, and thus has significant potential for developing therapies for regenerative medicine. Currently, there is no gold standard treatment for scars and impaired wound healing continues to be a challenge faced by clinicians worldwide. This review describes

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31

Ferreira, Gontijo De Amorim Natale. "Histological and ultrastructural changes of human skin and subcutaneous layer after use of stromal vascular fraction-enriched fat and adipose-derived stem cells: Anti-aging treatment." Doctoral thesis, 2016. http://hdl.handle.net/11562/937753.

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La proprietà rigenerativa dell innesto di grasso è stata descritta nella leteratura medica. Tuttavia, non è chiaro se i risultati clinici sono attribuibili alle cellule staminali o sono collegati ad altri componenti del tessuto adiposo. Questo lavoro si propone di analizzare i cambiamenti istologici e ultrastrutturali della cute e del tessuto sottocutaneo del viso invecchiati, dopo iniezione di innesto adiposo in aggiunta alla sua frazione vasculo-stromale (grasso arricchito con la FVS), ottenuto per centrifugazione, e di confrontare i risultati con quelli ottenuti con iniezione di cellule sta

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Butler, Mark James. "Modular Approach to Adipose Tissue Engineering." Thesis, 2011. http://hdl.handle.net/1807/29672.

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Despite the increasing clinical demand in reconstructive, cosmetic and correctional surgery there remains no optimal strategy for the regeneration or replacement of adipose tissue. Previous approaches to adipose tissue engineering have failed to create an adipose tissue depot that maintains implant volume in vivo long-term (>3 months). This is due to inadequate mechanical properties of the biomaterial and insufficient vascularization upon implantation. Modular tissue engineering is a means to produce large volume functional tissues from small sub-mm sized tissues with an intrinsic vasculari

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Correia, Joana Filipa Ribeiro. "Development of a platelet lysates-based hydrogel for nerve regeneration." Master's thesis, 2020. http://hdl.handle.net/10773/30911.

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Spinal cord injury (SCI) is a life-changing and debilitating medical condition. Currently, there is no definitive treatment. Novel regenerative medicine therapies have emerged in order to treat SCI. In this field, hydrogels are promising tools due to its high versatility of applications and design. Brain tissue has some particular characteristics such as its viscoelastic microenvironment and its soft extracellular matrix (ECM). Hydrogels can be designed to suit these characteristics and, therefore, be used to mimic brain tissue. Herein, we investigated the potential of a methacryl

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"The effect of scleraxis-transduced tendon-derived stem cells (TDSCs) on tendon repair in a rat model." 2013. http://library.cuhk.edu.hk/record=b5549324.

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我們假設，將scleraxis (Scx)基因轉導入肌腱來源的幹細胞（TDSC），製成TDSC-Scx細胞系。TDSC-Scx會促進肌腱修復。本研究的目的在於探索Scx促進TDSC成肌腱分化的作用，以及TDSC-Scx對肌腱修復的促進作用。<br>使用慢病毒載體將Scx轉導入TDSCs，不含Scx的空載作為對照也轉導入TDSCs，用載體上帶有的抗性基因，殺稻瘟菌素對細胞進行篩選。分別建成TDSC-Scx和TDSC-Mock細胞系。Scx 的表達分別用定量PCR以及免疫螢光在mRNA和蛋白水準進行鑒定。TDSC-Scx成肌腱，成軟骨和成骨方向的分化能力用定量PCR檢驗。用大鼠臏腱視窗損傷模型進行了細胞移植試驗，測試TDSC-Scx對肌腱損傷的修復作用。實驗分為三組：（1）支架組，（2）空載體組，（3）Scx組。在細胞移植後的第二，四，八周，收集正在修復中的肌腱樣品，進行植入細胞的存留狀態，鈣化，組織學和生物力學測驗。<br>TDSC-Scx比TDSC-Mock有更強的成肌腱分化能力。但是，在成軟骨-成骨分化方面，沒有結論。在動物試驗，植入的細胞在第二周仍然可見，但自第四周起，就不見了。在第八周，各組均有個別樣品輕微異位鈣化，但各組別間並無顯著差異。在早期，TDSC-Scx組比空載體組和支架組合得來更好的修復肌腱的能力。<br>TDSC-Scx可能促進肌腱損傷的早期修復。<br>We

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Prata, Fábio Emanuel Pires Aibéo. "Establishment of a protocol for the cryopreservation of cell sheets of adipose tissue stem cells." Master's thesis, 2016. http://hdl.handle.net/10400.1/8654.

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Dissertação de Mestrado, Ciências Biomédicas, Departamento de Ciências Biomédicas e Medicina, Universidade do Algarve, 2016<br>A Engenharia de Tecidos é uma área interdisciplinar da Medicina Regenerativa que visa criar e desenvolver substitutos biológicos para reparar, manter ou melhorar a função de tecidos lesados, com base em princípios da engenharia conjugados às ciências da vida. A Engenharia de Tecidos tira partido das propriedades de estruturas tri-dimensionais (3D) que combinadas com células estaminais pretendem recriar um ambiente semelhante ao nativo de um tecido. Estas estruturas 3D

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Sridhar, Akshayalakshmi. "Transcriptional Regulation of Retinal Progenitor Cells Derived from Human Induced Pluripotent Stem Cells." 2013. http://hdl.handle.net/1805/3454.

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Indiana University-Purdue University Indianapolis (IUPUI)<br>In order to develop effective cures for diseases and decipher disease pathology, the need exists to cultivate a better understanding of human development. Existing studies employ the use of animal models to study and model human development and disease phenotypes but the evolutionary differences between humans and other species slightly limit the applicability of such animal models to effectively recapitulate human development. With the development of human pluripotent stem cells (hPSCs), including Human induced Pluripotent stem ce

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Pereiro, Catarina Isabel Martins do. "Células estaminais do tecido adiposo: breve caracterização e a sua aplicação em dois casos clínicos." Master's thesis, 2016. http://hdl.handle.net/10400.26/17814.

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As células estaminais do tecido adiposo (do inglês adipose stem cell (ASC)) são células multipotentes que podem ser isoladas de diferentes locais e podem-se diferenciar em várias linhagens celulares, como adipogénica, osteogénica, condrogénica, entre outras. Estas células são capazes de atingir locais lesionados e exercer um papel importante a nível da regeneração tecidular e de modular a resposta imune pela secreção de moléculas intervenientes nos diferentes mecanismos fisiológicos. O processo de obtenção destas células passa pelo isolamento, cultura e expansão. A partir de uma amostra de go

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Mason, Michele E. "Generation of human pluripotent stem cell-derived micro-lenses to investigate lens development and lens toxicity." Thesis, 2018. http://hdl.handle.net/1959.7/uws:50887.

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Cataract is an opacification of the eye’s lens. It is the leading cause of blindness and causes life-impacting vision loss for millions of people worldwide. Currently the only treatment is surgical implantation of an intra-ocular lens. Due to the number of annual surgeries this approach is expensive and can result in a range of sightaffecting complications. Difficulties arise in accessing vision-restoring surgery for people with cataract living in developing countries due to inadequate access to cataract surgery. Greater understanding of cataract molecular mechanisms is required for developmen

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Elena, Dai Pre'. "ADIPOSE-DERIVED MULTIPOTENT STROMAL CELLS IN REGENERATIVE MEDICINE." Doctoral thesis, 2020. http://hdl.handle.net/11562/1018468.

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Beside adipose tissue had been considered a discard product for many years, recently its role as regenerative agent has been widely recognized. Adipose tissue is a connective tissue constituted of adipocytes interspersed with collagen fibers and stromal vascular fraction (SVF), composed of adipose-derived multipotent stromal cells (ASCs), pre-adipocytes, fibroblasts, vascular endothelial cells and immune cells. The regenerative role is played specifically by the SVF and, inside it, especially by the ASCs, by secreting angiogenetic, anti-apoptotic, antiinflammatory and immunomodulatory growth f

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Santos, Ana Rita Caseiro. "Cell-based therapies in regenerative medicicne: the therapeutic potential of umbilical cord and dental pulp derived stem/stromal cells." Doctoral thesis, 2020. https://hdl.handle.net/10216/126262.

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Abilez, Oscar John. "Development of a bioreactor imaging system for characterizing embryonic stem cell-derived cardiomyocytes." Thesis, 2010. http://hdl.handle.net/2152/ETD-UT-2010-05-663.

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Cardiovascular disease (CVD) affects more than 70 million Americans and is the number one cause of mortality in the United States. Because the regenerative capacity of adult tissues such as the heart is limited, human embryonic stem cells (hESC) have emerged as a source for potential cardiac therapies. However, despite the use of a variety of biochemical differentiation protocols, current yields of hESC-derived cardiomyocytes (CM) have been low. In the case of hESC-CM, which are inherently electromechanically active, additional forms of inducing a mature cardiac fate have not been fully ex

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Camões, Sérgio José Póvoas. "Modulating mesenchymal stem cells to overcome impaired wound healing." Doctoral thesis, 2020. http://hdl.handle.net/10451/48527.

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Mesenchymal stem cells (MSCs) have emerged as a promising strategy to the repair of damaged tissues, due to characteristics such as immunomodulation, anti-inflammatory properties, homing, protective and reparative effects. Additionally, MSCs have shown to exert their therapeutic activity by homing into injured tissues, cellular crosstalk and inducing tissue regeneration response through paracrine signalling, namely through exosomes. This thesis aimed to evaluate the role of the secretome (CM) and exosomes (Exo) derived from umbilical cord tissue (UC)-MSCs for damaged tissue treatment. Three-di

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