Bibliografías temáticas / Anti- Hypertensive Activity

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Literatura académica sobre el tema "Anti- Hypertensive Activity"

Autor: Grafiati
Publicado: 7 de junio de 2025
Última modificación: 2 de agosto de 2025

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Artículos de revistas sobre el tema "Anti- Hypertensive Activity"

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Odimegwu, Joy I., Oluwakayode Ezekiel Olatunji, Tolulope F. Okanlawon, and Ishola Ismail. "Diuretic and Anti-Hypertensive Activity of Clerodendrum Chinense (OSBECK) MABB. Aqueous Extract in 8% Salt Diet-Induced Hypertensive Rats." Advancements in Journal of Urology and Nephrology 6, no. 1 (2024): 01–10. http://dx.doi.org/10.33140/ajun.06.01.03.

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Diuresis refers to an increase in the rate of urine flow and sodium excretion from the system via the urine. It is a necessary excretory process that may prove difficult for some disease systems e.g. enlarged prostates. Hypertension occurs as a result of systolic blood pressure higher than 140 mmHg or a diastolic blood pressure higher than 90 mmHg. It is one of the most common chronic diseases affecting more than a billion people worldwide. A high dietary sodium intake is one of the factors associated with the development of hypertension. Clerodendrum chinensis is used by local communities in
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Shrivastava, Birendra, Parveen Kumar, Madan Mohan Gupta, and Anil Kumar Sharma. "Anti-Hypertensive Activity of Timolol Maleate Nanoparticle Loaded Transdermal Patch on Dexamethasone Induced Hypertensive Rats." Asian Pacific Journal of Health Sciences 6, no. 2 (2019): 145–51. http://dx.doi.org/10.21276/apjhs.2019.6.2.21.

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Wilson, J., M. A. Orchard, A. A. Spencer, J. A. Davies, and C. R. M. Prentice. "Anti-Hypertensive Drugs Non-Specifically Reduce “Spontaneous” Activation of Blood Platelets." Thrombosis and Haemostasis 62, no. 02 (1989): 776–80. http://dx.doi.org/10.1055/s-0038-1646901.

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SummaryAbnormal activation of blood platelets may be a contributory factor in the accelerated vascular disease which occurs in hypertension. We investigated the effects of lowering blood pressure in 12 patients with mild hypertension on several aspects of platelet function, initially in a placebo-controlled, double-blind, crossover study with nisoldipine, and subsequently in the same patients comparing nisoldipine with the patients’ usual anti-hypertensive therapy. Values were compared with those from an age, sex-matched control population. Seven hypertensive patients with renal failure were a
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Khanal, Hari, Ram Kishor Joshi, and Abhishek Upadhyay. "Anti- hypertensive activity of Ayurvedic medicinal plants." International Journal of Complementary and Alternative Medicine 13, no. 1 (2020): 7–12. http://dx.doi.org/10.15406/ijcam.2020.13.00485.

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Misal, A. R.* Maske Vaishnavi S. Pare Rutuja U. Kharat Anjali S. "Anti- Hypertensive Activity Of Ginger, Cardamom, Garlic." International Journal of Pharmaceutical Sciences 2, no. 3 (2024): 613–27. https://doi.org/10.5281/zenodo.10835119.

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Blood pressure is caused by another medical condition or use of certain medicine. It usually gets better after you treat that condition or stop taking medicines that are causing it Antihypertensive drug therapy has been remarkable improved in the last 60 years received different classes of drugs have received prominence with passage of time in this period. Before 1950 hardly any effective and toleratad antihypertensive was available .There is majer risk factors of hypertension are High sodium (salt)" overweight & obesity physical inactivity According to world health organisation Imperical
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Sitepu, Sari Desi Esta Ulina, Selamat Tuahta Sipayung, and Edi Kristianta Tarigan. "Socialization Of Compliance In Taking Antihypertension Medication At Karang Anyer Community Health Center." JURNAL PENGMAS KESTRA (JPK) 4, no. 2 (2024): 289–93. https://doi.org/10.35451/jpk.v4i2.1995.

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Hypertension is a type of disease whose treatment requires patients to take medication for a long period of time, even for life. This disease can cause new diseases or various complications. So that this does not happen, a good level of compliance with the consumption of anti-hypertension drugs is needed in hypertension sufferers. By taking anti-hypertension medication you can stop the disease and normalize blood pressure levels. Compliance with treatment for hypertensive patients is the main key because hypertension is a disease that must be continuously controlled or managed so as not to cau
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Silva, Maisa Gomes da, Sara Léa Fortes Barbosa, Diego Santos Silva, et al. "Bioactive Natural Products against Systemic Arterial Hypertension: A Past 20-Year Systematic and Prospective Review." Evidence-Based Complementary and Alternative Medicine 2022 (June 20, 2022): 1–21. http://dx.doi.org/10.1155/2022/8499625.

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Background. Systemic arterial hypertension is one of the most common cardiovascular risks, corresponding to 45% of deaths involving CVDs. The use of natural products, such as medicinal plants, belongs to a millennial part of human therapeutics history and has been employed as an alternative anti-hypertensive treatment. Objective. The present review aims to prospect some natural products already experimentally assayed against arterial hypertension through scientific virtual libraries and patent documents over the past 20 years. Search strategy. This is a systematic review of the adoption of the
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K, Sujeethasai, Manoharan A та Santhanakumar M. "Anti-Hypertensive Activity of Hydro Alcoholic Extract of Cìraka Cūraṇam on High Salt Loaded Wistar Albino Rats". International Journal of Research and Review 8, № 5 (2021): 110–15. http://dx.doi.org/10.52403/ijrr.20210516.

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Background: Hypertension is called as Silent killer. The most important risk factor for heart diseases and stroke and it may leads to premature death. Several medicinal plants have high effective in anti-hypertensive and anti-thrombotic activity without any side effects. Aim: To evaluate the anti-hypertensive activity of hydro alcoholic extract of Cìraka cūraṇam on deoxycorticosterone acetate (DOCA) salt induced wistar albino rats. Study design: Observational in-vivo study Place and duration of study: Animal house, Dept. of Pharmacology, Arulmigu Kalasalingam College of Pharmacy, Krishnankoil,
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Rahul, Kashyap1 Shivaji Patel2 Chandraprabha Dewangan*3 GyaneshKumar Sahu4. "Acorus Calamus: An Ancient Remedy with Modern Medicinal Applications." International Journal of Scientific Research and Technology 2, no. 2 (2025): 140–48. https://doi.org/10.5281/zenodo.14892736.

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The aim of the paper is provided information regarding incredible medicinal herb AcorusCalamus and its extract has various medicinal benefits like Anti diabetic activity, anti hypertensive effect, cytotoxic effect , immunosuppressive activity , antifungal activity , analgesic and anticonvulsant effect, bronchodilatory activity , licicidal activity, wound healing activity, coronary vasodilator effect, anti-cancer activity.The phytochemical constituent present in extract of oil are a-asarone, b-asarone, c-asarone, calamine, calamenenol, calameone, a-pinene,b-pinene, camphene, p-cymene, eugenyl a
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Li, Chia-Cheng, Yu-Chen Lee, Hsin-Yi Lo, Yu-Wen Huang, Chien-Yun Hsiang, and Tin-Yun Ho. "Antihypertensive Effects of Corn Silk Extract and Its Novel Bioactive Constituent in Spontaneously Hypertensive Rats: The Involvement of Angiotensin-Converting Enzyme Inhibition." Molecules 24, no. 10 (2019): 1886. http://dx.doi.org/10.3390/molecules24101886.

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Corn silk tea has been used in folk medicine for anti-hypertensive healthcare. Angiotensin-converting enzyme (ACE) plays a crucial role on the homeostasis of blood pressure. However, effects of corn silk tea on ACE activity and the presence of ACE inhibitory constituents in corn silk are still unknown. Here we applied proteomics and bioinformatics approaches to identify corn silk bioactive peptides (CSBps) that target ACE from the boiling water extract of corn silk (CSE). CSE significantly reduced systolic blood pressure (SBP) levels in spontaneously hypertensive rats and inhibited the ACE act
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Tesis sobre el tema "Anti- Hypertensive Activity"

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Santos, Marí Castro. "Estudo de Determinação Cromatográfica e Avaliação das Atividades Antifúngica e Anti-hipertensiva de Extratos Obtidos de Cuphea Glutinosa Cham. & Schltdl (lythraceae)." Universidade Federal do Pampa, 2014. http://dspace.unipampa.edu.br:8080/xmlui/handle/riu/235.

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Submitted by Sandro Camargo (sandro.camargo@unipampa.edu.br) on 2015-05-08T02:43:19Z No. of bitstreams: 1 127110045.pdf: 1527824 bytes, checksum: 960729a0a23069d5d40ec997cc3034b8 (MD5)<br>Made available in DSpace on 2015-05-08T02:43:19Z (GMT). No. of bitstreams: 1 127110045.pdf: 1527824 bytes, checksum: 960729a0a23069d5d40ec997cc3034b8 (MD5) Previous issue date: 2014-07-17<br>O gênero Cuphea, popularmente conhecido no Brasil por “sete-sangrias”, tem seu uso medicinal reconhecido devido aos efeitos diurético, hipotensor e cardioprotetor. No sul do Brasil, em região característica do bio
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Faria, Mariza. "Avaliação in vitro e in vivo da atividade anti-hipertensiva de hidrolisados comersiais de diversas fontes proteicas." [s.n.], 2006. http://repositorio.unicamp.br/jspui/handle/REPOSIP/256398.

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Orientador: Flavia Maria Netto<br>Dissertação (mestrado) - Universidade Estadual de Campinas, Faculdade de Engenharia de Alimentos<br>Made available in DSpace on 2018-08-07T15:37:07Z (GMT). No. of bitstreams: 1 Faria_Mariza_M.pdf: 1934217 bytes, checksum: d2b5831163c6c6be9fad1f62fd40b3fc (MD5) Previous issue date: 2006<br>Resumo: Peptídeos inibidores da enzima conversora de angiotensina (ECA) presentes em alimentos têm despertado o interesse de muitos pesquisadores, pois há evidências que sua ingestão, possa auxiliar na prevenção e no tratamento não medicamentoso da hipertensão. O potencial
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Chien, Tzu-Mei, and 簡慈美. "Study on the Anti-inflammatory Activity of the Extract of Acanthopanax trifoliatus Stem and Analysis of Prescriptions of Chinese Herbal Medicine for Diabetes Mellitus, Hyperlipidemia and Hypertension under the National Health Insurance in Taiwan." Thesis, 2015. http://ndltd.ncl.edu.tw/handle/a3h8m9.

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Libros sobre el tema "Anti- Hypertensive Activity"

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Zhang, Xuehong, Eunyoung Cho, and Hans-Olov Adami. Kidney Cancer. Oxford University Press, 2018. http://dx.doi.org/10.1093/oso/9780190676827.003.0023.

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The etiology of kidney cancer remains largely unknown. Cigarette smoking, obesity, and hypertension are well-established risk factors for kidney cancer. Although the current evidence is relatively mixed, other emerging risk factors include use of nonsteroidal anti-inflammatory drugs (NSAIDs), occupational exposure to trichloroethylene, and high parity in women. In contrast, physical activity and alcohol consumption have been consistently inversely associated with risk of kidney cancer. There is no convincing evidence of a causal link with any other specific food items or nutrients. Most kidney
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Capítulos de libros sobre el tema "Anti- Hypertensive Activity"

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Takano, T. "Anti-hypertensive activity of fermented dairy products containing biogenic peptides." In Lactic Acid Bacteria: Genetics, Metabolism and Applications. Springer Netherlands, 2002. http://dx.doi.org/10.1007/978-94-017-2029-8_22.

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Unnamatla, M. V. Basavanag, Fazlur-Rahman Nawaz Khan, and Erick Cuevas Yañez. "Tetrazoles: Structure and Activity Relationship as Anticancer Agents." In Key Heterocyclic Cores for Smart Anticancer Drug–Design Part I. BENTHAM SCIENCE PUBLISHERS, 2022. http://dx.doi.org/10.2174/9789815040074122010008.

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Heterocyclic compounds play an important role in drug design and discovery, and they have been used to treat a variety of diseases, including cancer. Cancer is one of the leading causes of death in the world. However, various drugs and therapies are available on the market. The novel synthetic drugs show promising in vitro activity, but the route to clinical trials is hampered by their low bioavailability and rapid metabolism. Tetrazoles have gained a lot of attention in recent years because they have the broadest biological activity spectrum of any heterocycle. Tetrazoles are a type of nitrog
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Kumar Sishu, Nayan, Chinnadurai Immanuel Selvara, and Deepa Sankar Parasurama. "A Review of Micropropagation of Glycyrrhiza glabra L. (Licorice)." In Micropropagation of Medicinal Plants. BENTHAM SCIENCE PUBLISHERS, 2024. http://dx.doi.org/10.2174/9789815196146124010016.

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Glycyrrhiza glabra belongs to the family Fabaceae and is commonly called licorice. It is an important medicinal plant in Europe, China, and the Mediterranean. The plant's therapeutic value is also mentioned in Ayurveda and Siddha. Licorice is cultivated for commercial purposes in many parts of the world because of its economic value and demand. It is used as a flavoring agent in juices, candies, soft drinks, and beverages because of its characteristic taste and smell. In addition, it is regarded as a sweetener and thirst quencher. Licorice contains phytochemicals, and the most abundant compoun
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Salva, Charumathi, Bhanusree P, Chakrapani P, Divya Sree S, Sravani T, and Sonali R. "COMPARATIVE STUDY BETWEEN AQUEOUS EXTRACT OF TWO SPECIES OF AMORPHOPHALLUS FOR ANTILIPASE POTENTIAL." In Futuristic Trends in Pharmacy & Nursing Volume 3 Book 6. Iterative International Publishers, Selfypage Developers Pvt Ltd, 2024. http://dx.doi.org/10.58532/v3bipn6p1ch4.

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Obesity is a significant public health concern inside developed nations. The presence of this factor is widely recognized as a significant contributor to the onset and progression of various chronic illnesses, such as cardiovascular disease, diabetes, and cancer. In this study, it was discovered that aqueous extracts of Amorphophallus peaoniifolius and Amorphophallus konjac both significantly inhibited pancreatic lipase activity. The presence of numerous secondary metabolites in the extract may be responsible for the inhibitory effect. As an anti-obesity medication, the extract may be utilized
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Piepoli, Massimo Francesco. "Exercise and sport in the management of cardiovascular diseases (ischaemic heart disease, heart failure, and hypertension)." In ESC CardioMed, edited by Antonio Pelliccia. Oxford University Press, 2018. http://dx.doi.org/10.1093/med/9780198784906.003.0709.

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Physical activity promotion is a key component of all preventive interventions in the management of cardiovascular diseases: many of the multi-risk factor benefits are mediated through its implementation. In cardiovascular diseases, physical exercise increases fibrinolysis and decreases coagulability, exerts anti-inflammatory effects, improves autonomic function, and prevents and restores age-related declines in endothelium-dependent vasodilatation, which may also help to explain the improvement in hyperaemic myocardial blood flow (flow reserve). Regular physical activity slows coronary artery
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Piepoli, Massimo Francesco. "Exercise and sport in the management of cardiovascular diseases (ischaemic heart disease, heart failure, and hypertension)." In ESC CardioMed, edited by Antonio Pelliccia. Oxford University Press, 2018. http://dx.doi.org/10.1093/med/9780198784906.003.0709_update_001.

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Physical activity promotion is a key component of all preventive interventions in the management of cardiovascular diseases: many of the multi-risk factor benefits are mediated through its implementation. In cardiovascular diseases, physical exercise increases fibrinolysis and decreases coagulability, exerts anti-inflammatory effects, improves autonomic function, and prevents and restores age-related declines in endothelium-dependent vasodilatation, which may also help to explain the improvement in hyperaemic myocardial blood flow (flow reserve). Regular physical activity slows coronary artery
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Siroha, Anil Kumar, Sneh Punia Bangar, and Shweta Suri. "Pigmented Rice: Composition and Health Effects." In Pigmented Cereals and Millets. The Royal Society of Chemistry, 2023. http://dx.doi.org/10.1039/9781837670291-00027.

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Pigmented rice has attracted major attention because of its higher levels of bioactive compounds and its higher concentration of micro- and macronutrients, compared with white rice. Pigmented rice cultivars are found in various colors i.e. black, purple, red, and brown. Pigmented rice contains good amounts of vitamins, minerals, fiber, and different phytochemicals with beneficial health effects. Pigmented rice is abundant in phenols, flavonoids, and antioxidant compounds. In comparison with white rice varieties, colored rice contains higher levels of polyphenols. Starch is the main component o
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Kaur, Prabhnain, Ritu Dahiya, Ginpreet Kaur, Harpal S. Buttar, Douglas W. Wilson, and Istvan G. Telessy. "Pathogenesis of Atherosclerosis and Coronary Heart Disease: Epidemiology, Diagnostic Biomarkers and Prevention by Nutraceuticals, Functional Foods, and Plant-Derived Therapies." In Biotechnology and Drug Development for Targeting Human Diseases. BENTHAM SCIENCE PUBLISHERS, 2024. http://dx.doi.org/10.2174/9789815238273124020010.

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Atherosclerosis is characterized by hardening/narrowing of arteries and reduction of blood flow to vital organs. Animal models and human research show that endothelial dysfunction and plaque development precede the pathogenesis of atherosclerosis, and related coronary heart disease, neurological, and renal disorders. Cardiac CT-scans are used to detect atherosclerosis. Early diagnosis of atherosclerosis reduces mortality, morbidity, and healthcare expenditures. Biomarkers like C-reactive protein, IL-6, IL-8, phospholipase A2, cardiac troponin, MicroRNA, miR-21, and other endothelial inflammati
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H.W. Leung, Edwin. "Current and Prospective Pharmaceutical Use of Algal Bioproducts." In Algae Science and Applications [Working Title]. IntechOpen, 2025. https://doi.org/10.5772/intechopen.1009486.

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This chapter explores the diverse applications of algal biocompounds in human health, focusing on dietary, cosmetic, and pharmaceutical uses. Algae, ranging from macroscopic kelp to microscopic single-celled organisms (including cyanobacteria), are a rich source of bioactive compounds with potential benefits for human health and well-being. This chapter begins by classifying algae and highlighting their historical use as food. It then delves into the current and prospective applications of algal biocompounds, dividing the discussion into three main sections. The first section examines the diet
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T. Galatage, Sunil, Sakshi N. Gurav, Mahadevi R. Moladi, et al. "Role of Leptin in Obesity Management: Current and Herbal Treatment." In Weight Management - Challenges and Opportunities [Working Title]. IntechOpen, 2022. http://dx.doi.org/10.5772/intechopen.105862.

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Obesity is an excessive accumulation of fat in the body associated with numerous complications such as development of hypertension, type 2 diabetes (T2DM), dyslipidemia, sleep apnea, and respiratory disorders; and ultimately life-threatening cardiovascular disease (CVD), stroke, certain types of cancer and osteoarthritis. In 2016, more than 1.9 billion adults aged 18 years and older were overweight. Of these, over 650 million adults were obese, that is over 39% of men and 40% of women were overweight. Rapid rise in obesity cases in both developed and developing countries and people suffering f
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Actas de conferencias sobre el tema "Anti- Hypertensive Activity"

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ELObeid, Tahra, Susanna Phoboo, and Kalidas Shetty. "Anti-diabetic and Anti-hypertensive Potential of Indigenous Edible plants of Qatar." In Qatar University Annual Research Forum & Exhibition. Qatar University Press, 2020. http://dx.doi.org/10.29117/quarfe.2020.0142.

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Aizoon Canariense, Cynomorium Coccineum, Glossonema Edule, and Malva Parviflora, edible desert plants from Qatar, were selected to determine levels of phenolic bioactives and potential health benefits for managing early stages of type 2 diabetes and hypertension. Aqueous extracts of C. Cocineum, contained soluble phenolics and had relatively high levels of antioxidant activity associated with α-glucosidase, α-amylase, and angiotensin- converting enzyme (ACE). G. Edule and M. Parviflora had moderate levels of anti-oxidant potential, soluble phenolics, and ACE inhibitory activity. The medicinal
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Daudt, Pedro Eugênio Deboni, Alexandre Grunfeld Starling Jardim, and Felipe Ibiapina dos Reis. "Arterial hypertension and cerebrovascular accidents. epidemiological profile of patients attended between 2013 and 2019 in Joinville, Santa Catarina, Brazil." In XIII Congresso Paulista de Neurologia. Zeppelini Editorial e Comunicação, 2021. http://dx.doi.org/10.5327/1516-3180.344.

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Introduction: Cerebrovascular accident (CVA) is the second cause of death in the world, and arterial hypertension (AH) is the main risk factor. Objetives: To evaluate the prevalence of AH and the epidemiological profile of patients who suffered CVA, first and recurrent events, registered at JOINVASC, between 2013 and 2019. Methodology: An observational, descriptive, retrospective study, analyzing demographic data and risk factors, in patients that suffered CVA, first or recurrent event, was done. Results: In the study period, 6057 CVA events were registered, 4402(72.6%) patients were classifie
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Daudt, Pedro Eugênio Deboni, Alexandre Grunfeld Starling Jardim, and Felipe Ibiapina dos Reis. "Arterial hypertension and cerebrovascular accidents. epidemiological profile of patients attended between 2013 and 2019 in Joinville, Santa Catarina, Brazil." In XIII Congresso Paulista de Neurologia. Zeppelini Editorial e Comunicação, 2021. http://dx.doi.org/10.5327/1516-3180.475.

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Introduction: Cerebrovascular accident (CVA) is the second cause of death in the world, and arterial hypertension (AH) is the main risk factor. Objectives: To evaluate the prevalence of AH and the epidemiological profile of patients who suffered CVA, first and recurrent events, registered at JOINVASC, between 2013 and 2019. Methodology: An observational, descriptive, retrospective study, analyzing demographic data and risk factors, in patients that suffered CVA, first or recurrent event, was done. Results: In the study period, 6057 CVA events were registered, 4402(72.6%) patients were classifi
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Rivera, Rodolfo Fernando. "Novelties in Medicinal Therapy of Uncontrolled Arterial Hypertension: SGLT2 Inhibitors and What Else?" In 7th International Congress of Cardionephrology KARNEF 2025. Punta Niš, 2025. https://doi.org/10.46793/karnef25.328r.

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Uncontrolled arterial hypertension (UAH remains one of the most challenging conditions in clinical practice, often exposing patients and clinicians to persistently elevated blood pressure (BP) levels despite optimal use of standard antihypertensive therapies. In this context, sodium-glucose co-transporter 2 inhibitors (SGLT2i), initially developed for the treatment of type 2 diabetes mellitus (T2DM), are emerging as promising agents in the management of BP regulation. Growing evidence demonstrates that these agents can effectively lower BP not only in patients with T2DM, but also in individual
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Rubani, Muhammad, and Arli Aditya Parikesit. "Molecular Simulation of Coffee Beans’ Natural Products as Lead Compounds for Stroke Remedy." In The 6th International Conference on Science and Engineering. Trans Tech Publications Ltd, 2024. http://dx.doi.org/10.4028/p-k5delo.

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The consumption of coffee has its health benefits and its risks, one of the risks is mostly related to cardiovascular diseases. One of the diseases is hypertension which is considered “the silent killer” as it is a serious condition which promotes other complications and typically has no symptoms for a period of time until it has done significant damage. Acute hypertension can lead to a stroke. It is a very serious medical condition where the blood flow to the brain is poor, causing the death of cells within the brain. Some medications, surgeries and other healthcare programs are capable of co
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Sandler, H., B. Gerdin, and T. Saldeen. "STUDIES ON THE ROLE OF THROMBOXANE IN THROMBIN-INDUCED PULMONARY INSUFFICIENCY IN THE RAT." In XIth International Congress on Thrombosis and Haemostasis. Schattauer GmbH, 1987. http://dx.doi.org/10.1055/s-0038-1643379.

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The pathophysiology of the acute pulmonary damage that may occur in association with sepsis, hemorrhagic shock and microembolism seems to involve the activity of cyclooxygenase derived arachidonate metabolites. In the rat, pulmonary microembolism due to infusion of thrombin together with inhibition of fibrinolysis has been found to induce pulmonary insufficiency with similarities to the clinical adult respiratory distress syndrome. The infusion of thrombin results in systemic hypotension, pulmonary hypertension and platelet aggregation, and subsequently, with a certain dealy in time, to increa
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SCHLEGEL, N., J. MOAKE, C. LOIRAT, M. F. HURTAUD, S. LEVY-TOLEDANO, and H. MATHIEU. "CHILDHOOD HEMOLYTIC UREMIC SYNDROME (HUS) : VON WILLEBRAND FACTOR (vWF) AND PLATELET AGGREGATING ACTIVITY (PAA) STUDIES." In XIth International Congress on Thrombosis and Haemostasis. Schattauer GmbH, 1987. http://dx.doi.org/10.1055/s-0038-1643475.

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It has been suggested that a vWF High Molecular Weight Multi-mers (HMWM) decrease or a PAA were involved in the pathogenesis of HUS. We have studied 8 children (6 girls,_2 boys; 7 months-8_1/2 years old) with HUS : plasma creatinine /μmol/l; mean(range)/=306 (105-524), hemoglobin (g/100ml)-7(6.3-7.8), schistocytes (%)=8(1-18), platelets (x103/mm3)-57(10-115). The vWF was studied quantitatively (antigen ; vWF RAg assay) and qualitatively (multimeric pattern : immunoblotting and autoradiography). PAA studied by incubating the patient's platelet poor plasma (RPR) with washed normal platelets (agg
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