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Artículos de revistas sobre el tema "Antigens Analysis Molecular aspects"

Autor: Grafiati

Publicado: 4 de junio de 2021

Última modificación: 28 de enero de 2023

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1

Mulloy, Barbara, and Ten Feizi. "Tricks of the trade in glycoscience: The preparation and analysis of a blood group A-active mucin glycoprotein." Biochemist 36, no. 4 (August 1, 2014): 18–20. http://dx.doi.org/10.1042/bio03604018.

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Many aspects of glycosylation are conserved among animals, and it can be advantageous and sometimes critical to identify a readily available and abundant source of carbohydrate material that harbours a hard-to-characterize antigen or ligand of interest. The Biochemical Journal Classic paper by Morgan and King is a well-written account of serviceable methods for the extraction and quantification of a carbohydrate antigen. These methods were highly influential in subsequent studies of the blood group antigens. Some of these tricks of the trade still have a place in modern glycobiology.

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2

De Masi, Luigi, Maria Antonia Argenio, Deborah Giordano, and Angelo Facchiano. "Molecular Aspects of Spike–ACE2 Interaction." Encyclopedia 2, no. 1 (January 10, 2022): 96–108. http://dx.doi.org/10.3390/encyclopedia2010007.

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A new betacoronavirus (CoV-2) is responsible for the pandemic of severe acute respiratory syndrome (SARS) that began in China at the end of 2019, today known as COronaVIrus Disease 2019 (COVID-19). Subsequent studies confirmed the human angiotensin-converting enzyme 2 (hACE2) as the main cell receptor of spike trimeric glycoprotein, located on the viral envelope, mediating the CoV-2 invasion into the host cells through the receptor-binding domain (RBD) of the spike. Computational analysis of the known experimental 3D structures of spike–ACE2 complexes evidenced distinguishing features in the m

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3

van der Zee, J. S., P. van Swieten, and R. C. Aalberse. "Serologic aspects of IgG4 antibodies. II. IgG4 antibodies form small, nonprecipitating immune complexes due to functional monovalency." Journal of Immunology 137, no. 11 (December 1, 1986): 3566–71. http://dx.doi.org/10.4049/jimmunol.137.11.3566.

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Abstract Human IgG4 antibodies directed against phospholipase A, the P1 antigen from Dermatophagoïdes pteronyssinus extracts, and cat albumin were found unable to cross-link antigen. Previously, it was demonstrated that IgG4 antibodies, in contrast to IgG1 antibodies, did not cross-link Sepharose-bound antigen and antigen added in solution. To eliminate the possibility that this phenomenon was caused by preferential binding of both IgG4 Fab fragments to the solid-phase-bound antigen, cross-linking of antigen was studied in a fluid-phase system. In this test, incapability of IgG4 antibodies to

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4

Bräunlein, Eva, Gaia Lupoli, Franziska Füchsl, Esam T. Abualrous, Niklas de Andrade Krätzig, Dario Gosmann, Lukas Wietbrock, et al. "Functional analysis of peripheral and intratumoral neoantigen-specific TCRs identified in a patient with melanoma." Journal for ImmunoTherapy of Cancer 9, no. 9 (September 2021): e002754. http://dx.doi.org/10.1136/jitc-2021-002754.

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BackgroundNeoantigens derived from somatic mutations correlate with therapeutic responses mediated by treatment with immune checkpoint inhibitors. Neoantigens are therefore highly attractive targets for the development of therapeutic approaches in personalized medicine, although many aspects of their quality and associated immune responses are not yet well understood. In a case study of metastatic malignant melanoma, we aimed to perform an in-depth characterization of neoantigens and respective T-cell responses in the context of immune checkpoint modulation.MethodsThree neoantigens, which we i

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5

Makhneva, Nataliya V., Yu S. Butov, and V. Yu Vasenova. "THE MOLECULAR BIOLOGICAL AND IMMUNE PATHOLOGIC CHARACTERISTICS UNDER AUTO-IMMUNE DISEASES OF SKIN." Medical Journal of the Russian Federation 23, no. 5 (October 15, 2017): 258–62. http://dx.doi.org/10.18821/0869-2106-2017-23-5-258-262.

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The skin and mucous membranes are the min barrier organs providing systemic defense from environmental effects. They actively participate in deliverance of organism from antigens of various origin due to availability of one's own elements of immune system. The failure in chain of immune defense causes deceleration of process of elimination of antigen damaging structure of one's own tissue. The article presents mechanism of elimination of immune complexes and examples of therapeutic procedures accelerating and normalizing this process. The maintenance and recovery of excretory function of skin

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6

Buscaglia, Carlos A., Julieta Alfonso, Oscar Campetella, and Alberto C. C. Frasch. "Tandem Amino Acid Repeats From Trypanosoma cruzi Shed Antigens Increase the Half-Life of Proteins in Blood." Blood 93, no. 6 (March 15, 1999): 2025–32. http://dx.doi.org/10.1182/blood.v93.6.2025.406k19_2025_2032.

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Proteins containing amino acid repeats are widespread among protozoan parasites. It has been suggested that these repetitive structures act as immunomodulators, but other functional aspects may be of primary importance. We have recently suggested that tandem repeats present in Trypanosoma cruzi trans-sialidase stabilize the catalytic activity in blood. Because the parasite releasestrans-sialidase, this delayed clearance of the enzyme might have implications in vivo. In the present work, the ability of repetitive units from different T. cruzi molecules in stabilizing trans-sialidase activity in

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7

Udintseva, I. N., O. Ye Chechina, N. G. Zhoukova, L. V. Lukashova, N. V. Ryazantseva, A. M. Poponina, L. A. Malysheva, N. N. Bartfeld, and S. A. Pershina. "Clinical immunological aspects of tick-borne encephalitis." Bulletin of Siberian Medicine 7, no. 5-2 (December 30, 2008): 438–43. http://dx.doi.org/10.20538/1682-0363-2008-5-2-438-443.

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In this article results of the clinical-immunological analysis with different forms tick-borne encephalitis of Tomsk Region during the period from 2000 to 2008 are represented. The revealled disbalance of cytokines alongside with breach of the expressions cytokines's receptor by limphocytes's cells, can be one of the main of the reasons to inefficiency answer when introducing the infectious agent in organism and shaping the chronic form to infectious pathology, in particular, with long presence of the antigen of the virus tick-borne encephalitis in blood. The trend to increase the level sick w

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8

BILIC, I., M. LEBERL, and M. HESS. "Identification and molecular characterization of numerous Histomonas meleagridis proteins using a cDNA library." Parasitology 136, no. 4 (January 21, 2009): 379–91. http://dx.doi.org/10.1017/s0031182008005477.

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SUMMARYHistomonas meleagridis is a protozoan parasite of various galliform birds causing a type of enterohepatitis termed histomonosis or ‘blackhead disease’. Due to the ban of chemotherapeutic substances and an increase in free-range poultry production, histomonosis is currently a re-emerging disease. So far limited molecular knowledge is available. In the present work, mRNAs coding for antigenic proteins of H. meleagridis were identified. For this purpose, a cDNA expression library was constructed from a mono-eukaryotic culture of H. meleagridis. The library was screened with polyclonal rabb

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9

Hui, Winnie W., Lisa E. Emerson, Beata Clapp, Austin E. Sheppe, Jatin Sharma, Johanna del Castillo, Mark Ou, et al. "Antigen-encapsulating host extracellular vesicles derived from Salmonella-infected cells stimulate pathogen-specific Th1-type responses in vivo." PLOS Pathogens 17, no. 5 (May 6, 2021): e1009465. http://dx.doi.org/10.1371/journal.ppat.1009465.

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Salmonella Typhimurium is a causative agent of nontyphoidal salmonellosis, for which there is a lack of a clinically approved vaccine in humans. As an intracellular pathogen, Salmonella impacts many cellular pathways. However, the intercellular communication mechanism facilitated by host-derived small extracellular vesicles (EVs), such as exosomes, is an overlooked aspect of the host responses to this infection. We used a comprehensive proteome-based network analysis of exosomes derived from Salmonella-infected macrophages to identify host molecules that are trafficked via these EVs. This anal

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10

Fu, Jie, Lenong Li, and Marlene Bouvier. "Modulation of MHC class I antigen presentation by the adenovirus E3-19K protein (100.8)." Journal of Immunology 186, no. 1_Supplement (April 1, 2011): 100.8. http://dx.doi.org/10.4049/jimmunol.186.supp.100.8.

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Abstract The presentation of viral antigens by MHC I to CTLs is vital for elimination of infected cells. In turn, viruses have evolved various strategies to abrogate antiviral cellular immune responses. For example, the adenovirus (Ad) E3-19K protein retains MHC I in the endoplasmic reticulum, dramatically suppressing the cell-surface presentation of viral antigens. Many aspects of how E3-19K exerts its function towards MHC I are poorly understood. This knowledge is important as the E3-19K/MHC I interaction is thought to play a role in enabling Ads to cause persistent infections. We characteri

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11

Rao, Chinthalapally V., Altaf Mohammed, Adam S. Asch, and Naveena B. Janakiram. "Immunoprevention of Pancreatic Cancer." Current Medicinal Chemistry 25, no. 22 (July 4, 2018): 2576–84. http://dx.doi.org/10.2174/0929867324666170223153509.

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Background: Pancreatic cancer (PC) is considered an incurable disease due to late diagnosis, rapid spread and negligible response treatment methods, with a 5-year survival rate of only 7%. Hence, there is an urgency in developing novel strategies for PC prevention. This review is focused on discussing the challenges in understanding complex immune functions in tumor microenvironment and host-induced immune responses against tumors, selection of antigens for development of preventive vaccines, lessons from immunoprevention clinical trials and challenges in developing future vaccines. Methods: 6

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12

PHAM, THO HOAN, KENJI SATOU, and TU BAO HO. "SUPPORT VECTOR MACHINES FOR PREDICTION AND ANALYSIS OF BETA AND GAMMA-TURNS IN PROTEINS." Journal of Bioinformatics and Computational Biology 03, no. 02 (April 2005): 343–58. http://dx.doi.org/10.1142/s0219720005001089.

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Tight turns have long been recognized as one of the three important features of proteins, together with α-helix and β-sheet. Tight turns play an important role in globular proteins from both the structural and functional points of view. More than 90% tight turns are β-turns and most of the rest are γ-turns. Analysis and prediction of β-turns and γ-turns is very useful for design of new molecules such as drugs, pesticides, and antigens. In this paper we investigated two aspects of applying support vector machine (SVM), a promising machine learning method for bioinformatics, to prediction and an

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13

Taylor, Diane E. "Helicobacter pyloriand Its Genome: Lessons from the Treasure Map." Canadian Journal of Gastroenterology 13, no. 3 (1999): 218–23. http://dx.doi.org/10.1155/1999/964025.

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The availability of the complete genome sequence ofHelicobacter pylori26695 has opened new avenues for research in the molecular biology of this gastric pathogen. The present review gives a general overview ofH pyloriobtained from the complete genome sequence and compares this with data previously obtained from cloning and functional studies ofH pylori. The cagA pathogenicity island of 40 kilobases, which encodes a type IV secretion system, is discussed. The diversity ofH pylorigenomes is well known, yet new data indicate that some aspects of the genome, particularly outer membrane protein gen

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14

GOLDSMITH, MARK A., and ARTHUR WEISS. "Generation and Analysis of a T-Lymphocyte Somatic Mutant for Studying Molecular Aspects of Signal Transduction by the Antigen Receptor." Annals of the New York Academy of Sciences 546, no. 1 Molecular Bas (December 1988): 91–103. http://dx.doi.org/10.1111/j.1749-6632.1988.tb21623.x.

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15

Felix, Fabiana, Alexandre Baccaro, and Lúcio Angnes. "Disposable Voltammetric Immunosensors Integrated with Microfluidic Platforms for Biomedical, Agricultural and Food Analyses: A Review." Sensors 18, no. 12 (November 24, 2018): 4124. http://dx.doi.org/10.3390/s18124124.

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Disposable immunosensors are analytical devices used for the quantification of a broad variety of analytes in different areas such as clinical, environmental, agricultural and food quality management. They detect the analytes by means of the strong interactions between antibodies and antigens, which provide concentration-dependent signals. For the herein highlighted voltammetric immunosensors, the analytical measurements are due to changes in the electrical signals on the surface of the transducers. The possibility of using disposable and miniaturized immunoassays is a very interesting alterna

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16

Nascimento, A. L. T. O., A. I. Ko, E. A. L. Martins, C. B. Monteiro-Vitorello, P. L. Ho, D. A. Haake, S. Verjovski-Almeida, et al. "Comparative Genomics of Two Leptospira interrogans Serovars Reveals Novel Insights into Physiology and Pathogenesis." Journal of Bacteriology 186, no. 7 (April 1, 2004): 2164–72. http://dx.doi.org/10.1128/jb.186.7.2164-2172.2004.

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ABSTRACT Leptospira species colonize a significant proportion of rodent populations worldwide and produce life-threatening infections in accidental hosts, including humans. Complete genome sequencing of Leptospira interrogans serovar Copenhageni and comparative analysis with the available Leptospira interrogans serovar Lai genome reveal that despite overall genetic similarity there are significant structural differences, including a large chromosomal inversion and extensive variation in the number and distribution of insertion sequence elements. Genome sequence analysis elucidates many of the

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17

Schröder, Sarah K., Herdit M. Schüler, Kamilla V. Petersen, Cinzia Tesauro, Birgitta R. Knudsen, Finn S. Pedersen, Frederike Krus, et al. "Genetic and Molecular Characterization of the Immortalized Murine Hepatic Stellate Cell Line GRX." Cells 11, no. 9 (April 30, 2022): 1504. http://dx.doi.org/10.3390/cells11091504.

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The murine cell line GRX has been introduced as an experimental tool to study aspects of hepatic stellate cell biology. It was established from livers of C3H/HeN mice that were infected with cercariae of Schistosoma mansoni. Although these cells display a myofibroblast phenotype, they can accumulate intracellular lipids and acquire a fat-storing lipocyte phenotype when treated with retinol, insulin, and indomethacin. We have performed genetic characterization of GRX and established a multi-loci short tandem repeat (STR) signature for this cell line that includes 18 mouse STR markers. Karyotypi

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18

Church, Sarah, Christina Bailey, Sarah Warren, and Lisa Butterfield. "946 Standardized transcriptional profiling for optimizing cellular therapies: a multi-center PICI-NanoString collaboration." Journal for ImmunoTherapy of Cancer 9, Suppl 2 (November 2021): A995. http://dx.doi.org/10.1136/jitc-2021-sitc2021.946.

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BackgroundThe field of cellular therapy remains one of the most promising areas for the development of new cancer treatments. To further these improvements, it is imperative to broadly understand cell therapy products at the molecular level and to identify factors that contribute to their efficacy. NanoString and the Parker Institute for Cancer Immunotherapy (PICI) have established a ground-breaking collaboration to characterize up to 1,000 apheresis and cellular therapy infusion products with the primary goal to dissect and study molecular pathways that correlate with optimal cellular therapi

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19

De Matos, Leandro Luongo, Damila Cristina Trufelli, Maria Graciela Luongo De Matos, and Maria Aparecida Da Silva Pinhal. "Immunohistochemistry as an Important Tool in Biomarkers Detection and Clinical Practice." Biomarker Insights 5 (January 2010): BMI.S2185. http://dx.doi.org/10.4137/bmi.s2185.

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The immunohistochemistry technique is used in the search for cell or tissue antigens that range from amino acids and proteins to infectious agents and specific cellular populations. The technique comprises two phases: (1) slides preparation and stages involved for the reaction; (2) interpretation and quantification of the obtained expression. Immunohistochemistry is an important tool for scientific research and also a complementary technique for the elucidation of differential diagnoses which are not determinable by conventional analysis with hematoxylin and eosin. In the last couple of decade

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20

Pickard, Derek, Ana Luisa Toribio, Nicola K. Petty, Andries van Tonder, Lu Yu, David Goulding, Bart Barrell, et al. "A Conserved Acetyl Esterase Domain Targets Diverse Bacteriophages to the Vi Capsular Receptor of Salmonella enterica Serovar Typhi." Journal of Bacteriology 192, no. 21 (September 3, 2010): 5746–54. http://dx.doi.org/10.1128/jb.00659-10.

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ABSTRACT A number of bacteriophages have been identified that target the Vi capsular antigen of Salmonella enterica serovar Typhi. Here we show that these Vi phages represent a remarkably diverse set of phages belonging to three phage families, including Podoviridae and Myoviridae. Genome analysis facilitated the further classification of these phages and highlighted aspects of their independent evolution. Significantly, a conserved protein domain carrying an acetyl esterase was found to be associated with at least one tail fiber gene for all Vi phages, and the presence of this domain was conf

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21

Varma, Garima, Pratishtha Rawat, Manisha Jalan, Manjula Vinayak, and Madhulika Srivastava. "Influence of a CTCF-Dependent Insulator on Multiple Aspects of Enhancer-Mediated Chromatin Organization." Molecular and Cellular Biology 35, no. 20 (August 3, 2015): 3504–16. http://dx.doi.org/10.1128/mcb.00514-15.

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Developmental stage-specific enhancer-promoter-insulator interactions regulate the chromatin configuration necessary for transcription at various loci and additionally for VDJ recombination at antigen receptor loci that encode immunoglobulins and T-cell receptors. To investigate these regulatory interactions, we analyzed the epigenetic landscape of the murine T-cell receptor β (TCRβ) locus in the presence and absence of an ectopic CTCF-dependent enhancer-blocking insulator, H19-ICR, in genetically manipulated mice. Our analysis demonstrated the ability of the H19-ICR insulator to restrict seve

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22

Scharfstein, J., M. Schechter, M. Senna, J. M. Peralta, L. Mendonça-Previato, and M. A. Miles. "Trypanosoma cruzi: characterization and isolation of a 57/51,000 m.w. surface glycoprotein (GP57/51) expressed by epimastigotes and bloodstream trypomastigotes." Journal of Immunology 137, no. 4 (August 15, 1986): 1336–41. http://dx.doi.org/10.4049/jimmunol.137.4.1336.

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Abstract We have recently described the application of a purified glycoprotein of 25,000 Mr (GP25) of Trypanosoma cruzi in serodiagnosis of Chagas' disease. Purified GP25 lacks appreciable immunogenicity in some animal species, in spite of being generally antigenic to parasitized hosts. The underlying cause for these contrasting observations has not been determined, but it may relate to the drastic extraction conditions used in the original isolation procedure, and possible damage inflicted to the native form of this antigen. This report describes the molecular properties of a GP25-related pri

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23

Fox, Barbara A., Alejandra Falla, Leah M. Rommereim, Tadakimi Tomita, Jason P. Gigley, Corinne Mercier, Marie-France Cesbron-Delauw, Louis M. Weiss, and David J. Bzik. "Type II Toxoplasma gondiiKU80Knockout Strains Enable Functional Analysis of Genes Required for Cyst Development and Latent Infection." Eukaryotic Cell 10, no. 9 (April 29, 2011): 1193–206. http://dx.doi.org/10.1128/ec.00297-10.

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ABSTRACTType IIToxoplasma gondiiKU80knockouts (Δku80) deficient in nonhomologous end joining were developed to delete the dominant pathway mediating random integration of targeting episomes. Gene targeting frequency in the type II Δku80Δhxgprtstrain measured at the orotate (OPRT) and the uracil (UPRT) phosphoribosyltransferase loci was highly efficient. To assess the potential of the type II Δku80Δhxgprtstrain to examine gene function affecting cyst biology and latent stages of infection, we targeted the deletion of four parasite antigen genes (GRA4,GRA6,ROP7, andtgd057) that encode characteri

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24

Zoure, Abdou Azaque, Henri Gautier Ouedraogo, Tani Sagna, T. Rebecca Compaore, Serge Théophile Soubeiga, Kadari Cisse, Dinanibé Kambire, et al. "Molecular diagnosis of COVID-19 in Burkina Faso: successful challenge." International Journal of Biological and Chemical Sciences 16, no. 1 (June 8, 2022): 440–63. http://dx.doi.org/10.4314/ijbcs.v16i1.37.

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COVID-19 has worsened the health situation in Burkina Faso. In fact, the country has known a peak of the second wave, which began in November, and ended around January 2021. Biological diagnosis has played a key role in the management of COVID-19. The aim of this review paper is to address the practical aspects that laboratories have faced in order to meet the challenge of SARS-CoV-2 diagnosis in Burkina Faso. According to international requirements, Burkina Faso has used real-time Reverse Transcription Polymerase Chain Reaction (rRT-PCR) as the “gold standard” for the diagnosis of COVID-19. F

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25

Zhang, Wei, Wenhua Xie, Jianqiang Wang, Xi Chen, Jianwen Fang, Yongsheng Chen, Jun Li, Libing Yu, Depu Chen, and Peng George Wang. "Recent Progress in Glycochemistry and Green Chemistry." Current Organic Chemistry 3, no. 3 (May 1999): 241–67. http://dx.doi.org/10.2174/1385272803666220202193253.

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Abstract: This two-part article will focus on the most recent research efforts from the Wang's group in areas of glycochemistry and green chemistry. In the first part, we wish to address the progress in synthesis, conformational analysis, and transformations of some biologically active a galactosyl oligosaccharides. Carbohydrate structures containing Gala1-3Galterminus (a-Gal epitopes) are xenoactive antigens and are considered to be the major cause for hyperacute rejection in xenotransplantation. The latest chemo-enzymatic synthesis of a-galactosyl epitopes using a recombinant a1,3-galactosy

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26

Iwamoto, Sadahiko. "Molecular aspects of Rh antigens." Legal Medicine 7, no. 4 (July 2005): 270–73. http://dx.doi.org/10.1016/j.legalmed.2004.12.002.

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27

Balla, Keir M., Geanncarlo Lugo-Villarino, Jan M. Spitsbergen, David L. Stachura, Yan Hu, Karina Bañuelos, Octavio Romo-Fewell, Raffi V. Aroian, and David Traver. "Eosinophils in the zebrafish: prospective isolation, characterization, and eosinophilia induction by helminth determinants." Blood 116, no. 19 (November 11, 2010): 3944–54. http://dx.doi.org/10.1182/blood-2010-03-267419.

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Abstract Eosinophils are granulocytic leukocytes implicated in numerous aspects of immunity and disease. The precise functions of eosinophils, however, remain enigmatic. Alternative models to study eosinophil biology may thus yield novel insights into their function. Eosinophilic cells have been observed in zebrafish but have not been thoroughly characterized. We used a gata2:eGFP transgenic animal to enable prospective isolation and characterization of zebrafish eosinophils, and demonstrate that all gata2hi cells in adult hematopoietic tissues are eosinophils. Although eosinophils are rare in

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28

Zippel, Claus, Sarah C. Ronski, Sabine Bohnet-Joschko, Frederik L. Giesel, and Klaus Kopka. "Current Status of PSMA-Radiotracers for Prostate Cancer: Data Analysis of Prospective Trials Listed on ClinicalTrials.gov." Pharmaceuticals 13, no. 1 (January 13, 2020): 12. http://dx.doi.org/10.3390/ph13010012.

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The recent development of dedicated prostate-specific membrane antigen (PSMA) targeted radioligands shows the potential to change and improve the diagnosis and therapy of prostate cancer. There is an increasing number of prospective trials to further establish these tracers in the clinical setting. We analyzed data from the ClinicalTrials.gov registry including all listed prospective trials with PSMA-ligands for prostate cancer as of October 2019 concerning the different tracers and study characteristics. We found n = 104 eligible studies with a total of n = 25 different tracers in use: most f

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Melarkode Vattekatte, Akhila, Nicolas Ken Shinada, Tarun J. Narwani, Floriane Noël, Olivier Bertrand, Jean-Philippe Meyniel, Alain Malpertuy, Jean-Christophe Gelly, Frédéric Cadet, and Alexandre G. de Brevern. "Discrete analysis of camelid variable domains: sequences, structures, and in-silico structure prediction." PeerJ 8 (March 6, 2020): e8408. http://dx.doi.org/10.7717/peerj.8408.

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Antigen binding by antibodies requires precise orientation of the complementarity- determining region (CDR) loops in the variable domain to establish the correct contact surface. Members of the family Camelidae have a modified form of immunoglobulin gamma (IgG) with only heavy chains, called Heavy Chain only Antibodies (HCAb). Antigen binding in HCAbs is mediated by only three CDR loops from the single variable domain (VHH) at the N-terminus of each heavy chain. This feature of the VHH, along with their other important features, e.g., easy expression, small size, thermo-stability and hydrophil

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Young, Matthew, and Michael Criscitiello. "Demonstrating the immune response of D. rerio using keyhole limpet hemocyanin (EDU1P.249)." Journal of Immunology 192, no. 1_Supplement (May 1, 2014): 49.3. http://dx.doi.org/10.4049/jimmunol.192.supp.49.3.

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Abstract In this project, immunization of a model aquatic organism is used in the classroom to facilitate understanding of molecular biology, evolution and the vertebrate adaptive immune system. Molecular immunoglobulin and T cell receptor cloning, sequencing and repertoire analysis techniques that I learned in the Criscitiello Comparative Immunogenetics Lab at Texas A&M this summer were applied to analysis of the lymphocyte antigen receptor repertoire in zebrafish. Students at A&M Consolidated High School performed experiments to quantify and qualify various aspects of the immune resp

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Ahnaf, Ilman, Luisetto Mauro, Rafa Ahmed Yesvi, Musa Naeem, Abu Syed Md., Anan Sabit Ibtisam, and Haque Tazwan. "SARS-CoV-2 infection and phylogenetic analysis with the risk factors in human body alongside the pulmonary effects and medication." Insights in Biology and Medicine 4, no. 1 (November 6, 2020): 023–29. http://dx.doi.org/10.29328/journal.ibm.1001018.

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Related the extremely transmittable abilities of SARS-CoV-2,a harmonious virus to the bat CoV, gets transmitted by three principal processes-- the inhalation of droplets from the SARS-CoV-2 infected person, contacting to the person, and by the surfaces and materials defiled with the virus. Whereupon bat Coronavirus is mostly like the pandemic causing virus SARS-CoV-2, bats are often deliberated and figured out as a possible primary host although no intermediate has not been defined yet in the wherewithal of transmission. The Spike Glycoprotein plays an important role in the case of penetration

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32

Stürzbecher, H. W., C. Addison, and J. R. Jenkins. "Characterization of mutant p53-hsp72/73 protein-protein complexes by transient expression in monkey COS cells." Molecular and Cellular Biology 8, no. 9 (September 1988): 3740–47. http://dx.doi.org/10.1128/mcb.8.9.3740-3747.1988.

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Several mutant, but not wild-type, p53 proteins form complexes with hsp72/73 heat shock-related proteins in simian virus 40-transformed monkey COS cells. We carried out a detailed biochemical and structural mapping analysis of p53 and report here that p53-hsp72/73 complex formation showed considerable structural specificity. Such complexes were remarkably stable, but unlike analogous complexes formed between p53 and simian virus 40 T antigen, they did not form in in vitro association assays. p53-hsp72/73 complex formation in vivo appears to be dependent on aspects of mutant p53 protein conform

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Wei, Eric X., Vasiliki Leventaki, John K. Choi, Susana C. Raimondi, Elizabeth M. Azzato, Sheila A. Shurtleff, Menchu G. Ong, Diana M. Veillon, James D. Cotelingam та Rodney E. Shackelford. "γδ T-Cell Acute Lymphoblastic Leukemia/Lymphoma: Discussion of Two Pediatric Cases and Its Distinction from Other Mature γδ T-Cell Malignancies". Case Reports in Hematology 2017 (2017): 1–7. http://dx.doi.org/10.1155/2017/5873015.

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Gamma delta (γδ) T-cell antigen receptor (TCR) expression and its related T-cell differentiation are not commonly reported in T-cell acute lymphoblastic leukemia/lymphoma (T-ALL). Here we report two pediatric T-ALL cases and present their clinical features, histology, immunophenotypes, cytogenetics, and molecular diagnostic findings. The first patient is a two-year-old girl with leukocytosis, circulating lymphoblasts, and a cryptic insertion of a short-arm segment at 10p12 into the long-arm segment of 11q23 resulting in an MLL and AF10 fusion transcript, which may be the first reported in γδ T

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Kostareli, Efterpi, Tatjana Smilevska, Kostas Stamatopoulos, Anastasia Kouvatsi, and Achilles Anagnostopoulos. "Chronic lymphocytic leukaemia: An immunobiology approach." Srpski arhiv za celokupno lekarstvo 136, no. 5-6 (2008): 319–23. http://dx.doi.org/10.2298/sarh0806319k.

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B cell chronic lymphocytic leukaemia (CLL) is the most common adult leukaemia that follows an extremely variable clinical course. Several important prognostic parameters defining pathogenic and clinical subgroups of CLL have been identified and validated recently. The biological significance of immunoglobulin (Ig) heavy chain variable region gene (IgHV) mutational status and associated ZAP-70 over-expression, CD38 and chromosomal aberrations have enabled to identify patients at high risk for early disease progression and inferior survival. Moreover, studies of the B cell antigen receptor (BCR)

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Havranek, Ondrej, Jingda Xu, Stefan Koehrer, Zhiqiang Wang, Justin M. Comer, Lisa Becker, Allen F. Yi, et al. "Molecular Aspects of Tonic B-Cell Receptor Signaling in Diffuse Large B-Cell Lymphoma Provide Biomarkers and Targets for Specific Inhibition." Blood 128, no. 22 (December 2, 2016): 779. http://dx.doi.org/10.1182/blood.v128.22.779.779.

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Abstract Introduction. Targeting antigen-driven B-cell receptor (BCR) signaling with the BTK inhibitor ibrutinib is clinically effective against most B-cell lymphomas, including activated B-cell diffuse large B-cell lymphoma (ABC-DLBCL), but not germinal center B-cell (GCB) DLBCL. We have formally confirmed that GCB-DLBCL cell lines utilize tonic BCR signaling, by showing: 1) sensitivity (variable) to knockout (KO) of the BCR, SYK, and CD19; 2) dependence on CD79A ITAM phosphorylation; and 3) independence from BCR antigen specificity. However, uncertainty remains about molecular events in upst

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Dabelsteen, E. "Molecular Biological Aspects of Acquired Bullous Diseases." Critical Reviews in Oral Biology & Medicine 9, no. 2 (April 1998): 162–78. http://dx.doi.org/10.1177/10454411980090020201.

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Bullous diseases of the oral mucosa and skin were originally classified on the basis of clinical and histological criteria. The discovery of autoantibodies in some of these patients and the introduction of molecular biology have resulted in a new understanding of the pathological mechanisms of many of the bullous lesions. In this article, updated topics of the immune-mediated bullous lesions which involve oral mucosa and skin are reviewed. Pemphigus antigens, which are desmosomal-associated proteins and belong to the cadherin superfamily of cell adhesion proteins, have been isolated, and their

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Hendrickson, Jeanne E., Nicole H. Smith, Kathryn R. Girard-Pierce, Christopher A. Tormey, Kate L. Henry, James C. Zimring, and Sean R. Stowell. "Development of a Murine Model of Weak Kel: Similarities to Weak Rh(D)." Blood 120, no. 21 (November 16, 2012): 842. http://dx.doi.org/10.1182/blood.v120.21.842.842.

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Abstract Abstract 842 Introduction: Aspects of RBC antigens that define their immunogenicity are not fully understood. Multiple studies in humans have demonstrated Rh(D) to be the most immunogenic RBC antigen, yet the same antigen present in lower copy number (weak Rh(D)) is, with rare exception, considered non-immunogenic. A better understanding of factors influencing RBC alloimmunogenicity would be helpful in predicting antibody responses in transfusion and pregnancy situations alike, as well as in managing donor RBC inventory. Herein, we describe the generation of transgenic mice with diffe

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Barreto, Leidy Viviana, George Emílio Barreto, Ludis Morales, Orlando Emilio Acevedo, and Janneth González Santos. "Proteína LIC10494 de Leptospira interrogans serovar Copenhageni: modelo estructural y regiones funcionales asociadas." Universitas Scientiarum 17, no. 1 (January 1, 2012): 16. http://dx.doi.org/10.11144/javeriana.sc17-1.plol.

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<p><strong>Objective</strong>. Predict by computational means the 3D structure of the antigenic protein LIC10494 and report associated important functional regions for its pathogenicity and immunogenicity. <strong>Materials and methods</strong>. We performed a computational analysis of the primary structure of LIC10494 using the servers BLAST, PROTPARAM, PROTSCALE, DAS, SOSUI, TOPPRED, TMAP, TMpred, SPLIT4, PHDHTM, TMHMM2, HMMTOP2, GLOBPLOT and PROSITE. The secondary structure was obtained by consensus of the algorithms SOPM, PREDATOR GOR4, DPM and DSC. The approa

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Ballard, Jimmy D., R. John Collier, and Michael N. Starnbach. "Anthrax Toxin as a Molecular Tool for Stimulation of Cytotoxic T Lymphocytes: Disulfide-Linked Epitopes, Multiple Injections, and Role of CD4+ Cells." Infection and Immunity 66, no. 10 (October 1, 1998): 4696–99. http://dx.doi.org/10.1128/iai.66.10.4696-4699.1998.

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ABSTRACT We have previously demonstrated that anthrax toxin-derived proteins, protective antigen (PA) and the amino-terminal portion of lethal factor (LFn), can be used in combination to deliver heterologous molecules to the cytosol of mammalian cells. In this study we examined the ability of an LFn-peptide disulfide-linked heterodimer to prime cytotoxic T lymphocytes (CTL) in the presence of PA. A mutant of LFn that contains a carboxy-terminal reactive cysteine was generated. This form of LFn could be oxidized with a synthetic cysteine containing peptide to form a heterodimer of the protein a

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Oltz, E. M., F. W. Alt, W. C. Lin, J. Chen, G. Taccioli, S. Desiderio, and G. Rathbun. "A V(D)J recombinase-inducible B-cell line: role of transcriptional enhancer elements in directing V(D)J recombination." Molecular and Cellular Biology 13, no. 10 (October 1993): 6223–30. http://dx.doi.org/10.1128/mcb.13.10.6223-6230.1993.

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Rapid analysis of mechanisms that regulate V(D)J recombination has been hampered by the lack of appropriate cell systems that reproduce aspects of normal prelymphocyte physiology in which the recombinase is activated, accessible antigen receptor loci are rearranged, and rearrangement status is fixed by termination of recombinase expression. To generate such a system, we introduced heat shock-inducible V(D)J recombination-activating genes (RAG) 1 and 2 into a recombinationally inert B-cell line. Heat shock treatment of these cells rapidly induced high levels of RAG transcripts and RAG proteins

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Horvat-Switzer, Regina D., and Alexis A. Thompson. "Stromal Contact Inhibits Effects of Phorbol Esters but Does Not Inhibit Staurosporine Induced Megakaryocytic Differentiation in K562 Cells." Blood 106, no. 11 (November 16, 2005): 4315. http://dx.doi.org/10.1182/blood.v106.11.4315.4315.

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Abstract Development of human megakaryocytes is modulated at least in part by direct contact with stromal cells, however, the mechanisms that control this process have not been fully elucidated. Stromal contact is not needed for lineage commitment and direct contact of human progenitor cells with marrow stroma negatively influences megakaryocytic development. The K562 human erythroleukemia cell line has been extensively used as a model to study molecular aspects of megakaryocytic differentiation. Treatment of K562 with either phorbol-12 myristate-13 acetate (PMA), a PKC activator, or staurospo

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Morozov, Giora, Huaying Zhao, Michael Mage, Lisa Boyd, Peter Schuck, Kannan Natarajan та David Margulies. "Tapasin-related protein TAPBPR interacts directly with peptide-free MHC-I/β2-microgolbulin complexes (APP3P.101)". Journal of Immunology 192, № 1_Supplement (1 травня 2014): 111.2. http://dx.doi.org/10.4049/jimmunol.192.supp.111.2.

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Abstract The molecular mechanism by which MHC-I molecules are loaded with peptides is crucial to fundamental aspects of antigen presentation relating to self-tolerance and CD8 T cell activation. To gain insight into the mechanism of MHC-I peptide loading we have studied human TAPBPR (TAP binding protein-related) protein, which is 22% identical to tapasin in amino acid sequence, widely expressed and IFN-γ inducible, but is not part of the peptide-loading complex (PLC). To understand the interaction of TAPBPR with MHC-I, we produced recombinant soluble TAPBPR and evaluated its interactions with

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Stover, D. G., A. M. Cushman-Vokoun, C. L. Vnencak-Jones, and J. Berlin. "Analysis of BRAF and KRAS mutations in colorectal cancer and rectal carcinogenesis via fluorescent allele-specific PCR." Journal of Clinical Oncology 29, no. 4_suppl (February 1, 2011): 436. http://dx.doi.org/10.1200/jco.2011.29.4_suppl.436.

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436 Background: Molecular analysis has become increasingly relevant in the evaluation of colorectal carcinomas. Mutations in Ras-MAPK pathway proteins KRAS (present in 30-40% of colorectal cancer) and BRAF (10-14% of colorectal cancer) or mismatch repair (MMR) enzymes can impact response to therapy and/or can assist in defining hereditary predisposition. High frequency microsatellite instability (MSI) in colorectal cancer is associated with improved outcomes. Targeted therapies against BRAF and other components of the Ras-MAPK signaling pathway are becoming important aspects of treatment in co

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Slavkovic, Bojana, Marija Guc-Scekic, Gordana Bunjevacki, S. Djuricic, Aleksandra Krstic, D. Micic, Dragana Vujic, M. Kuzmanovic, and Nada Rasovic-Gvozdenovic. "Acute leukemia of childhood: A single institution's experience." Archives of Biological Sciences 57, no. 1 (2005): 11–17. http://dx.doi.org/10.2298/abs0501011s.

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The aim of this study was to investigate distribution of immunophenotypic and cytogenetic features of childhood acute leukemia (AL) in the cohort of 239 newly diagnosed patients registered at the leading pediatric oncohematology center in the country during a six-year period (1996-2002). With approximately 60-70% of all childhood AL cases in Serbia and Montenegro being diagnosed and treated in this institution the used data represent a valid research sample to draw conclusions for entire country. On the basis of five phenotypic markers, the distribution of immunological subtypes was as follows

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Inman, R. D. "Immunogenetic aspects of host immune response." Canadian Journal of Microbiology 34, no. 3 (March 1, 1988): 319–22. http://dx.doi.org/10.1139/m88-058.

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The central role of histocompatibility leukocyte antigens (HLA) class II molecules in antigen presentation has received great attention in recent years, yet class I molecules have been defined as primarily functioning as a restriction element for cytotoxic T cell killing of virus-infected cells. Extensive clinical evidence, however, indicates that the HLA class I genes are strongly associated with nonseptic complications of enteric and genitourinary bacterial infections. Ninety percent of patients with Reiter's syndrome and reactive arthritis are positive for HLA-B27, yet the mechanism of dise

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Greslehner, Gregor P. "The vaccinologist’s “dirty little secret”: a better understanding of structure-function relationships of viral immunogens might advance rational HIV vaccine design." Archives of Virology 166, no. 5 (February 19, 2021): 1297–303. http://dx.doi.org/10.1007/s00705-021-04982-7.

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AbstractI will offer a conceptual analysis of different notions of structure and function of viral immunogens and of different structure-function relationships. My focus will then be on the mechanisms by which the desired immune response is induced and why strategies based on three-dimensional molecular antigen structures and their rational design are limited in their ability to induce the desired immunogenicity. I will look at the mechanisms of action of adjuvants (thus the wordplay with Janeway’s “immunologist’s dirty little secret”). Strategies involving adjuvants and other (more successful

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Pershing, Nicole L., Aurélie Kapusta, Shannon Nielsen, Hillary Crandall, E. Kent Korgenski, Carrie L. Byington, Krow Ampofo, and Anne J. Blaschke. "#64: An odyssey Beyond the Capsule: Genetic Determinants of Pediatric Invasive Streptococcus pneumoniae Empyema." Journal of the Pediatric Infectious Diseases Society 10, Supplement_1 (March 1, 2021): S7. http://dx.doi.org/10.1093/jpids/piaa170.021.

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Abstract Background Streptococcus pneumoniae is among the most common causes of invasive bacterial infections in children, including pneumonia, bacteremia, and meningitis. Over 90 different serotypes (ST) of pneumococcus exist, with enrichment of some ST within specific invasive phenotypes. Other than capsular genes, molecular determinants of particular invasive phenotypes remain largely unknown. Although vaccination targeting especially invasive ST capsular antigens has successfully decreased the incidence of invasive pneumococcal disease (IPD), new ST have emerged, suggesting methods to targ

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Tanji, Takahiro, Kenji Nishikori, Hirohisa Shiraishi, Masatomo Maeda, and Ayako Ohashi-Kobayashi. "Co-operative function and mutual stabilization of the half ATP-binding cassette transporters HAF-4 and HAF-9 in Caenorhabditis elegans." Biochemical Journal 452, no. 3 (May 31, 2013): 467–75. http://dx.doi.org/10.1042/bj20130115.

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Caenorhabditis elegans HAF-4 and HAF-9 are half ABC (ATP-binding-cassette) transporters that are highly homologous to the human lysosomal peptide transporter TAPL [TAP (transporter associated with antigen processing)-like; ABCB9]. We reported previously that both HAF-4 and HAF-9 localize to the membrane of a subset of intestinal organelles, and are required for the formation of these organelles and other physiological aspects. In the present paper, we report the genetic and physical interactions between HAF-4 and HAF-9. Overexpression of HAF-4 and HAF-9 did not rescue the intestinal organelle

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Ndam, Nicaise Tuikue, and Philippe Deloron. "Molecular Aspects ofPlasmodium falciparumInfection during Pregnancy." Journal of Biomedicine and Biotechnology 2007 (2007): 1–13. http://dx.doi.org/10.1155/2007/43785.

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Cytoadherence ofPlasmodium-falciparum-parasitized red blood cells (PRBCs) to host receptors is the key phenomenon in the pathological process of the malaria disease. Some of these interactions can originate poor outcomes responsible for 1 to 3 million annual deaths mostly occurring among children in sub-Saharan Africa. Pregnancy-associated malaria (PAM) represents an important exception of the disease occurring at adulthood in malaria endemic settings. Consequences of this are shared between the mother (maternal anemia) and the baby (low birth weight and infant mortality). Demonstrating that p

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Shaw, M. W., N. H. Arden, and H. F. Maassab. "New aspects of influenza viruses." Clinical Microbiology Reviews 5, no. 1 (January 1992): 74–92. http://dx.doi.org/10.1128/cmr.5.1.74.

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Influenza virus infections continue to cause substantial morbidity and mortality with a worldwide social and economic impact. The past five years have seen dramatic advances in our understanding of viral replication, evolution, and antigenic variation. Genetic analyses have clarified relationships between human and animal influenza virus strains, demonstrating the potential for the appearance of new pandemic reassortants as hemagglutinin and neuraminidase genes are exchanged in an intermediate host. Clinical trials of candidate live attenuated influenza virus vaccines have shown the cold-adapt

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