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Artículos de revistas sobre el tema "Antineoplastic agents"

Autor: Grafiati
Publicado: 4 de junio de 2021
Última modificación: 9 de junio de 2025

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1

Carlson, Patricia A. "Antineoplastic agents." Critical Care Nursing Quarterly 18, no. 4 (February 1996): 1–15. http://dx.doi.org/10.1097/00002727-199602000-00002.

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2

Menta, Ernesto, and Manlio Palumbo. "Novel antineoplastic agents." Expert Opinion on Therapeutic Patents 7, no. 12 (December 1997): 1401–26. http://dx.doi.org/10.1517/13543776.7.12.1401.

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3

Menta, Ernesto, and Manlio Palumbo. "Antineoplastic agents 1998." Expert Opinion on Therapeutic Patents 8, no. 12 (December 1998): 1627–72. http://dx.doi.org/10.1517/13543776.8.12.1627.

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4

Pettit, G. R., Y. Kamano, R. Aoyagi, C. L. Herald, D. L. Doubek, J. M. Schmidt, and J. J. Rudloe. "Antineoplastic agents 100." Tetrahedron 41, no. 6 (January 1985): 985–94. http://dx.doi.org/10.1016/s0040-4020(01)96466-x.

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5

Bukowski, Ronald M. "Novel antineoplastic agents." Current Oncology Reports 2, no. 1 (January 2000): 9–10. http://dx.doi.org/10.1007/s11912-000-0004-1.

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6

Hong, Samuel J., Edward C. Li, Linda M. Matusiak, and Glen T. Schumock. "Spending on Antineoplastic Agents in the United States, 2011 to 2016." Journal of Oncology Practice 14, no. 11 (November 2018): e683-e691. http://dx.doi.org/10.1200/jop.18.00069.

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Purpose: Recent cancer drug approvals are lauded as being more effective with relatively fewer adverse effects, but these treatments come with a great cost to the US health care system. There is little information on recent trends in actual antineoplastic expenditures representative of the whole US health care system or by sector. Therefore, the objective of this study was to describe antineoplastic expenditures in the United States by year and sector. Methods: This was a retrospective, cross-sectional study of IQVIA (formerly QuintilesIMS) National Sales Perspective data for the period of January 1, 2011, to December 31, 2016. Actual expenditures were totaled by health care sector and calendar year, then adjusted for medical-cost inflation to 2016 dollars. Growth was calculated as the percentage increase from the previous year. Results: Total expenditures of antineoplastic agents across all channels grew from $26.8 billion in 2011 to $42.1 billion in 2016. Antineoplastic spending increased 12.2% in 2016 (compared with the previous year), followed by 15.6% in 2015, 13.4% in 2014, 6.3% in 2013, and 0.4% in 2012. Throughout the study period, 96.5% of total antineoplastic expenditures occurred within clinics, mail-order pharmacies, nonfederal hospitals, and retail pharmacies. Conclusion: Antineoplastic expenditures are expected to increase because of continuing development and approval of costly targeted cancer therapies. Cost containment and utilization management strategies must be balanced so as not to restrict access or disrupt innovation. Future policies should focus on ensuring safe and appropriate use of antineoplastics while balancing long-term drug costs.
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7

DOLL, DONALD C., Q. SCOT RINGENBERG, and JOHN W. YARBRO. "Antineoplastic Agents and Pregnancy." Obstetrical & Gynecological Survey 45, no. 6 (June 1990): 376. http://dx.doi.org/10.1097/00006254-199006000-00008.

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8

Pettit, George R., Noeleen Melody, and Jean-Charles Chapuis. "Antineoplastic Agents. 605. Isoquinstatins." Journal of Natural Products 81, no. 3 (September 19, 2017): 451–57. http://dx.doi.org/10.1021/acs.jnatprod.7b00352.

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9

Hussain, M. A. ha, A. N. toinette J. Wozniak, and M. A. rk B. Edelstein. "Neurotoxicity of antineoplastic agents." Critical Reviews in Oncology/Hematology 14, no. 1 (February 1993): 61–75. http://dx.doi.org/10.1016/1040-8428(93)90006-p.

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10

Castells, M. "Hypersensitivity to Antineoplastic Agents." Current Pharmaceutical Design 14, no. 27 (September 1, 2008): 2892–901. http://dx.doi.org/10.2174/138161208786369803.

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11

Fernandez, F. "Psychotoxicity from antineoplastic agents." Journal of Clinical Oncology 5, no. 2 (February 1987): 319–20. http://dx.doi.org/10.1200/jco.1987.5.2.319.

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12

McNabb, Lorna, Eva Metrot, Micaela Ferrington, Bruce Sunderland, Richard Parsons, Tandy-Sue Copeland, Siobhan Corscadden, Selina Tong, and Petra Czarniak. "Assessment of patient perceptions of counselling on oral antineoplastic agents by a dedicated cancer services pharmacist in an outpatient cancer clinic." PLOS ONE 19, no. 6 (June 13, 2024): e0304011. http://dx.doi.org/10.1371/journal.pone.0304011.

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Background Oral antineoplastic agents have caused a paradigm shift in cancer treatment, however, they produce many unique challenges. Although oral antineoplastics can have complex administration regimes, low adherence rates and high possibilities of drug-drug interactions, they are administered unsupervised at home. Cancer services pharmacists have the required skillsets to improve patient outcomes associated with oral antineoplastic treatment by increasing patient health literacy, improving concordance and optimising administration protocols. Aim To evaluate patients’ perceptions, experiences and overall satisfaction with dedicated clinical pharmacist consultations in patients treated with oral antineoplastic agents at a major public hospital. Method In this retrospective cross-sectional study at a quaternary hospital in Western Australia, data were collected by a paper questionnaire (mailed in March 2022) to a random sample of 191 patients initiated on oral antineoplastic drugs between January 2021 and February 2022. Demographics, prescribed antineoplastic drug/s, cancer type data were collected including using 5-point Likert scale questions assess patients’ overall satisfaction with the clinical pharmacist consultations. Results The questionnaire response rate was 27.7% (52/188) (mean age 63.2 years; 57.5% female). Most patients (42/52; 80.8%) were satisfied with pharmacist consultations, trusted the pharmacist’s advice (45/52; 86.5%), considered that the pharmacist improved their understanding of how to manage side effects (43/52; 82.7%) and they provided an important service in outpatient care (45/52; 86.5%). Conclusion Overall, patients reported positive perceptions, experiences, and satisfaction with the cancer services pharmacist counselling services during their oral antineoplastic treatment.
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13

Melamed, Andra J., and Michael L. Kleinberg. "Handling Considerations for Cancer Chemotherapeutic Agents." Drug Intelligence & Clinical Pharmacy 22, no. 3 (March 1988): 247–51. http://dx.doi.org/10.1177/106002808802200317.

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Since the introduction of antineoplastic agents in the 1940s, there have been reports of the effects of these agents on workers who have had prolonged contact with them. The Regional Oncology Drug Information Center (RODIC) at Memorial Sloan-Kettering Cancer Center receives numerous inquiries nationwide regarding our policies and procedures for handling antineoplastic agents. In August 1987, RODIC conducted a computerized literature search on the handling of antineoplastic agents and the risks to hospital employees coming in contact with these agents. We used the MEDLINE system from 1966 to the present, limiting the search to English-language articles. This article provides a comprehensive bibliography on the handling of antineoplastic agents.
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14

Yamashiro, Yoshiko, Yoshikazu Fukuoka, Akira Yotsuji, Takashi Yasuda, Isamu Saikawa, and Yasushi Ueda. "Interactions of antimicrobial agents and antineoplastic agents." Journal of Antimicrobial Chemotherapy 18, no. 6 (1986): 703–8. http://dx.doi.org/10.1093/jac/18.6.703.

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15

Garcia, Gwenalyn, and Jean Paul Atallah. "Antineoplastic agents and thrombotic microangiopathy." Journal of Oncology Pharmacy Practice 23, no. 2 (June 23, 2016): 135–42. http://dx.doi.org/10.1177/1078155216628324.

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Thrombotic microangiopathy is an uncommon but reported adverse effect of a variety of antineoplastic drugs, including chemotherapy agents such as mitomycin C and gemcitabine, and newer targeted agents such as the vascular endothelial growth factor inhibitors. We present a review of thrombotic microangiopathy associated with antineoplastic agents and its implications in current cancer therapy.
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16

Sutton, Karen, Tara B. Sanft, Tish M. Knobf, and Izuchukwu K. Ibe. "Musculoskeletal Effects of Antineoplastic Agents." Journal of the American Academy of Orthopaedic Surgeons 27, no. 22 (November 2019): 834–39. http://dx.doi.org/10.5435/jaaos-d-17-00713.

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17

PATTERSON, WILLIAM B. "Occupational Hazard from Antineoplastic Agents." Annals of Internal Medicine 103, no. 6_Part_1 (December 1, 1985): 965. http://dx.doi.org/10.7326/0003-4819-103-6-965_2.

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18

Graeve, Catherine Utecht, Patricia Marie McGovern, Bruce Alexander, Timothy Church, Andrew Ryan, and Martha Polovich. "Occupational Exposure to Antineoplastic Agents." Workplace Health & Safety 65, no. 1 (October 7, 2016): 9–20. http://dx.doi.org/10.1177/2165079916662660.

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Approximately 8 million health care workers are unnecessarily exposed to highly toxic drugs used to treat cancer; antineoplastic drugs can contribute to negative health effects for these workers. The drugs have been detected in the urine of workers and on the floors and counters of worksites. Safety precautions that could reduce the risk of exposure are underutilized. This cross-sectional study of 163 oncology health care workers used a survey to measure workplace and individual factors, and environmental sampling to measure surface contamination. The study objective was to identify potential exposures to antineoplastic drugs and factors influencing safety behavior. Personal protective equipment (PPE) use was lower than recommended; unit of employment was significantly associated with PPE use. Chemical residue from antineoplastic drugs was found, revealing potential exposures. Workplace safety must be a higher organizational priority. The contamination of common work areas where PPE use is not expected was of utmost concern.
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19

Bozkurt, Kürşat A., Burak Uzel, Canan Akman, Mustafa Özgüroğlu, and Nil Molinas Mandel. "Intrathoracic Extravasation of Antineoplastic Agents." American Journal of Clinical Oncology 26, no. 2 (April 2003): 121–23. http://dx.doi.org/10.1097/00000421-200304000-00003.

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20

Shahab, Nasir, Syed Haider, and Donald C. Doll. "Vascular Toxicity of Antineoplastic Agents." Seminars in Oncology 33, no. 1 (February 2006): 121–38. http://dx.doi.org/10.1053/j.seminoncol.2005.11.006.

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21

Fortner, Clarence L., and Paul J. Vilk. "Aspects of Investigational Antineoplastic Agents." Journal of Pharmacy Practice 4, no. 1 (February 1991): 64–71. http://dx.doi.org/10.1177/089719009100400107.

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Investigational drugs are regulated by the Food and Drug Administration (FDA) and are not available for widespread patient use. They are screened and evaluated extensively before they are administered to humans in clinical trials. The clinical development process is divided into three phases: phase I, II, and III. Protocols for the investigational agent in each of these phases must be approved by an institutional review board and the patient must be informed of the risks of the study and sign an informed consent document. Once adequate clinical data are collected and analyzed, the information is submitted to the FDA for their review and approval for marketing. Prior to that approval, the FDA may approve broader distribution of the drug for specific indications under a Treatment Investigational New Drug (IND) or the National Cancer Institute's (NCI) group C mechanism. Pharmacists can play a unique role during development of the Treatment IND by contributing to design of the protocol and screening patient qualifications. The investigator of the clinical trial has responsibility for the conduct of the clinical trial and must comply with FDA regulations and sponsor policies. This is a US government work. There are no restrictions on its use.
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22

Chitambar, Christopher R. "Gallium compounds as antineoplastic agents." Current Opinion in Oncology 16, no. 6 (November 2004): 547–52. http://dx.doi.org/10.1097/01.cco.0000142071.22226.d2.

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23

Hamnvik, O. P. R., P. R. Larsen, and E. Marqusee. "Thyroid Dysfunction from Antineoplastic Agents." JNCI Journal of the National Cancer Institute 103, no. 21 (October 18, 2011): 1572–87. http://dx.doi.org/10.1093/jnci/djr373.

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24

Grangé, Steven, and Paul Coppo. "Thrombotic microangiopathies and antineoplastic agents." Néphrologie & Thérapeutique 13 (April 2017): S109—S113. http://dx.doi.org/10.1016/j.nephro.2017.01.016.

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25

Pettit, George R., Noeleen Melody, and Jean-Charles Chapuis. "Antineoplastic Agents. 606. The Betulastatins." Journal of Natural Products 81, no. 3 (January 5, 2018): 458–64. http://dx.doi.org/10.1021/acs.jnatprod.7b00536.

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26

Pettit, George R., Noeleen Melody, and Jean-Charles Chapuis. "Antineoplastic Agents. 607. Emetine Auristatins." Journal of Natural Products 83, no. 5 (April 23, 2020): 1571–76. http://dx.doi.org/10.1021/acs.jnatprod.0c00031.

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27

Pettit, G. R., S. B. Singh, A. Goswami, and R. A. Nieman. "Antineoplastic agents 157. Quassia kerstingII1." Tetrahedron 44, no. 11 (January 1988): 3349–54. http://dx.doi.org/10.1016/s0040-4020(01)85969-x.

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28

Pettit, George R., Venkatswamy Gaddamidi, Delbert L. Herald, Sheo Bux Singh, Gordon M. Cragg, Jean M. Schmidt, Fred E. Boettner, M. Williams, and Yoneo Sagawa. "Antineoplastic Agents, 120. Pancratium littorale." Journal of Natural Products 49, no. 6 (November 1986): 995–1002. http://dx.doi.org/10.1021/np50048a005.

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29

Pettit, George R., Gordon M. Cragg, Sheo Bux Singh, James A. Duke, and Dennis L. Doubek. "Antineoplastic Agents, 162. Zephyranthes candida." Journal of Natural Products 53, no. 1 (January 1990): 176–78. http://dx.doi.org/10.1021/np50067a026.

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30

Rogers, Bonnie. "Antineoplastic Agents Action and Toxicities." AAOHN Journal 34, no. 11 (November 1986): 530–38. http://dx.doi.org/10.1177/216507998603401104.

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31

Bodet, C. A., J. H. Jorgensen, and D. J. Drutz. "Antibacterial activities of antineoplastic agents." Antimicrobial Agents and Chemotherapy 28, no. 3 (September 1, 1985): 437–39. http://dx.doi.org/10.1128/aac.28.3.437.

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32

Pettit, George R., Noeleen Melody, Michael Simpson, Michael Thompson, Delbert L. Herald, and John C. Knight. "Antineoplastic Agents 500. Narcistatin†,1." Journal of Natural Products 66, no. 1 (January 2003): 92–96. http://dx.doi.org/10.1021/np020225i.

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33

Bozkurt, Kürşat A., Burak Uzel, Canan Akman, Mustafa Özgüroğlu, and Nil Molinas Mandel. "Intrathoracic Extravasation of Antineoplastic Agents." American Journal of Clinical Oncology 26, no. 2 (April 2003): 121–23. http://dx.doi.org/10.1097/01.coc.0000017088.74592.96.

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34

Borch, Richard F., and Thomas J. Montine. "Renal toxicity of antineoplastic agents." Toxicology Letters 53, no. 1-2 (September 1990): 93–96. http://dx.doi.org/10.1016/0378-4274(90)90100-z.

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35

Weiss, Raymond B., and James R. Baker. "Hypersensitivity reactions from antineoplastic agents." Cancer and Metastasis Reviews 6, no. 3 (November 1987): 413–32. http://dx.doi.org/10.1007/bf00144273.

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36

Hall, Amy L., Paul A. Demers, George Astrakianakis, Calvin Ge, and Cheryl E. Peters. "Estimating National-Level Exposure to Antineoplastic Agents in the Workplace: CAREX Canada Findings and Future Research Needs." Annals of Work Exposures and Health 61, no. 6 (June 8, 2017): 656–58. http://dx.doi.org/10.1093/annweh/wxx042.

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AbstractObjectives:Occupational exposure to antineoplastic agents occurs in various environments and is associated with increased cancer risk and adverse reproductive outcomes. National-level information describing the location and extent of occupational exposure to antineoplastic agents is unavailable in Canada and most other countries. CAREX Canada aimed to estimate the prevalence and relative levels of occupational exposures to antineoplastic agents across work setting, occupation, and sex.Methods:‘Exposure’ was defined as any potential for worker contact with antineoplastic agents. Baseline numbers of licensed workers were obtained from their respective professional bodies. For unlicensed workers, Census data or data extrapolated from human resources reports (e.g., staffing ratios) were used. Prevalence was estimated by combining population estimates with exposure proportions from peer-reviewed and grey literature. Exposure levels (classified as low, moderate, and high) by occupation and work setting were estimated qualitatively by combining estimates of contact frequency and exposure control practices.Results:Approximately 75000 Canadians (0.42% of the total workforce) are estimated as occupationally exposed to antineoplastic agents; over 75% are female. The largest occupational group exposed to antineoplastic agents is community pharmacy workers, with 30200 exposed. By work setting, 39000 workers (52% of all exposed) are located in non-hospital settings; the remaining 48% are exposed in hospitals. The majority (75%) of workers are in the moderate exposure category.Conclusions:These estimates of the prevalence and location of occupational exposures to antineoplastic agents could be used to identify high-risk groups, estimate disease burden, and target new research and prevention activities. The limited secondary data available for developing these estimates highlights the need for increased quantitative measurement and documentation of antineoplastic agent contamination and exposure, particularly in work environments where use is emerging.
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37

Hamazaki, Risa, and Yoshihiro Uesawa. "Characterization of Antineoplastic Agents Inducing Taste and Smell Disorders Using the FAERS Database." Pharmaceuticals 17, no. 9 (August 23, 2024): 1116. http://dx.doi.org/10.3390/ph17091116.

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Taste and smell disorders can worsen the nutritional status of patients receiving chemotherapy and potentially affect drug treatment. However, there is limited knowledge on antineoplastic agents that induce taste and smell disorders. Therefore, we used the U.S. Food and Drug Administration Adverse Event Reporting System database to analyze the characteristics of patients and antineoplastic agents in relation to taste and smell disorders. No gender differences related to the onset of taste and smell disorders were found, whereas older age was identified as a possible risk factor. Among the antineoplastic agent classes, protein kinase inhibitors appeared to be particularly likely to induce taste and smell disorders. According to the cluster and principal component analyses, antineoplastic agents were deemed to induce taste or smell disorders. In addition, antineoplastic agents that decreased or changed these sensations could be classified. These findings might be useful in selecting drugs for patients experiencing similar side effects.
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38

Mary Philip, Sherin, Joji Johnson, Litha Johnson, and Bharath Rangarajan. "A Review on Antineoplastic Agents Induced Toxicities and its Managements." International Journal of Science and Research (IJSR) 10, no. 8 (August 27, 2021): 1005–12. https://doi.org/10.21275/sr21818165637.

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39

Johnson, Candace S. "Modulation of chemotherapy antineoplastic agents with biologic agents." Current Opinion in Oncology 4, no. 6 (December 1992): 1108. http://dx.doi.org/10.1097/00001622-199212000-00016.

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40

Chen, Rong. "A Pharmacovigilance Study of the Association between Antineoplastic Agents and Neutropenia Adverse Events Based on Food and Drug Administration Adverse Event Reporting System Data." Toxicology: Current Research 8, no. 1 (October 30, 2024): 1–8. http://dx.doi.org/10.24966/tcr-3735/100029.

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Neutropenia is one of the most common adverse events associated with antineoplastic agents. However, comprehensive real-world studies on the relationship between antineoplastic agents and neutropenia are relatively scarce.
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41

Zhang, Hai-Long, and Yiqian Li. "Recent development of drugs for osteoporosis and anti-cancer agents: a patent analysis." Pharmaceutical Patent Analyst 10, no. 2 (March 2021): 73–82. http://dx.doi.org/10.4155/ppa-2021-0004.

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Osteoporosis and cancer are becoming a major public health problem. Some studies have shown that osteoporosis drugs may have anti-cancer effects. To better understand the relationship between drugs for osteoporosis and antineoplastic agents, and to better demonstrate recent developments for patents concerning drugs for osteoporosis, we conducted an analysis of US patents. The results indicated that there was a good correlation between agents for osteoporosis and antineoplastic agents, which indicated that numerous anti-osteoporosis agents displayed antineoplastic activities. Our study was the first one to provide new evidence, through comprehensive analysis, for a correlation between anti-osteoporosis agents and anticancer agents. The present study may open new avenues for developing anticancer drugs and expanding the application role of anti-osteoporosis agents.
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42

Beckwith, M. Christina, and Linda S. Tyler. "Preventing Medication Errors with Antineoplastic Agents, Part 1." Hospital Pharmacy 35, no. 5 (May 2000): 511–26. http://dx.doi.org/10.1177/001857870003500502.

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Goal — The goal of this program is to present practical ways to prevent medication errors with antineoplastic agents, identify common types of medication errors, and describe a system for reducing the incidence of medication errors and responding appropriately to antineoplastic medication errors. Objectives — At the completion of this program, the participant will be able to: 1. Describe the scope and impact of medication errors 2. Define common terms used in medication error literature. 3. List four common types of prescribing errors made with anti-neoplastic agents. 4. Identify steps where medication errors may occur during the drug ordering, preparation, and administration process. 5. Describe ways to prevent errors at each step of the medication use process. 6. Recommend a procedure for reporting and monitoring antineoplastic medication errors within the institution. 7. Describe a system for the non-punitive management of antineoplastic medication errors in health care systems.
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43

Boschi, Rita, and Elena Rostagno. "Extravasation of antineoplastic agents: prevention and treatments." Pediatric Reports 4, no. 3 (August 1, 2012): 28. http://dx.doi.org/10.4081/pr.2012.e28.

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The extravasation of antineoplastic agents is an unwanted and distressing situation that can easily occur. It may cause severe and irreversible local injuries. Left untreated, vesicant chemotherapy extravasation can potentially cause tissue necrosis, functional impairment and permanent disfigurement. This article provides a review of current literature regarding recommendations on the prevention and treatment of extravasation of antineoplastic agents.
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44

&NA;. "Antineoplastic agents can cause allergic reactions." Reactions Weekly &NA;, no. 428 (November 1992): 4. http://dx.doi.org/10.2165/00128415-199204280-00008.

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45

&NA;. "Pharmacokinetic drug interactions with antineoplastic agents." Drugs & Therapy Perspectives 5, no. 9 (May 1995): 12–14. http://dx.doi.org/10.2165/00042310-199505090-00005.

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46

BATRA, JANENDRA K., CHII M. LIN, ERNEST HAMEL, LEONARD JURD, and LARRY J. POWERS. "New Antineoplastic Agents with Antitubulin Activity." Annals of the New York Academy of Sciences 466, no. 1 Dynamic Aspec (June 1986): 785–87. http://dx.doi.org/10.1111/j.1749-6632.1986.tb38459.x.

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47

McDiarmid, Melissa, and Thomas Egan. "Acute Occupational Exposure to Antineoplastic Agents." Journal of Occupational and Environmental Medicine 30, no. 12 (December 1988): 984–87. http://dx.doi.org/10.1097/00043764-198812000-00020.

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48

Dimopoulou, I., A. Bamias, P. Lyberopoulos, and M. A. Dimopoulos. "Pulmonary toxicity from novel antineoplastic agents." Annals of Oncology 17, no. 3 (March 2006): 372–79. http://dx.doi.org/10.1093/annonc/mdj057.

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49

Delitheos, A., I. Karavokyros, and E. Tiligada. "Response ofSaccharomyces cerevisiaestrains to antineoplastic agents." Journal of Applied Bacteriology 79, no. 4 (October 1995): 379–83. http://dx.doi.org/10.1111/j.1365-2672.1995.tb03151.x.

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Phillips, Nancy C. "The Safe Handling of Antineoplastic Agents." Journal of Pharmacy Technology 1, no. 1 (January 1985): 19–24. http://dx.doi.org/10.1177/875512258500100108.

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