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Ricklin, Meret. "Penetration of ASM 981 in canine skin /". Bern : [s.n.], 2004. http://www.ub.unibe.ch/content/bibliotheken_sammlungen/sondersammlungen/dissen_bestellformular/index_ger.html.
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Cheng, Kun. "Deformable models for adaptive radiotherapy planning". Thesis, University of Edinburgh, 2016. http://hdl.handle.net/1842/22893.
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Radiotherapy is the most widely used treatment for cancer, with 4 out of 10 cancer patients receiving radiotherapy as part of their treatment. The delineation of gross tumour volume (GTV) is crucial in the treatment of radiotherapy. An automatic contouring system would be beneficial in radiotherapy planning in order to generate objective, accurate and reproducible GTV contours. Image guided radiotherapy (IGRT) acquires patient images just before treatment delivery to allow any necessary positional correction. Consequently, real-time contouring system provides an opportunity to adopt radiotherapy on the treatment day. In this thesis, freely deformable models (FDM) and shape constrained deformable models (SCDMs) were used to automatically delineate the GTV for brain cancer and prostate cancer. Level set method (LSM) is a typical FDM which was used to contour glioma on brain MRI. A series of low level image segmentation methodologies are cascaded to form a case-wise fully automatic initialisation pipeline for the level set function. Dice similarity coefficients (DSCs) were used to evaluate the contours. Results shown a good agreement between clinical contours and LSM contours, in 93% of cases the DSCs was found to be between 60% and 80%. The second significant contribution is a novel development to the active shape model (ASM), a profile feature was selected from pre-computed texture features by minimising the Mahalanobis distance (MD) to obtain the most distinct feature for each landmark, instead of conventional image intensity. A new group-wise registration scheme was applied to solve the correspondence definition within the training data. This ASM model was used to delineated prostate GTV on CT. DSCs for this case was found between 0.75 and 0.91 with the mean DSC 0.81. The last contribution is a fully automatic active appearance model (AAM) which captures image appearance near the GTV boundary. The image appearance of inner GTV was discarded to spare the potential disruption caused by brachytherapy seeds or gold markers. This model outperforms conventional AAM at the prostate base and apex region by involving surround organs. The overall mean DSC for this case is 0.85.
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Rasi, Stefano. "Manipolazione di Bytecode Java con la libreria ASM". Bachelor's thesis, Alma Mater Studiorum - Università di Bologna, 2020.
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La piattaforma Java è stata introdotta da Sun Microsystem nel 1995 con il motto "write once, run everywhere" (scrivi una volta, esegui ovunque). La macchina virtuale Java o Java Virtual Machine (JVM), insieme al linguaggio omonimo, ha permesso agli sviluppatori di scrivere programmi per dispositivi e sistemi operativi diversi senza dovere modificare il proprio codice, e compilando per tutti questi una sola volta.
Questa tecnologia si è rivelata molto utile con la diffusione del web, permettendo l'esecuzione e la condivisione di programmi compilati tra diversi computer in un ottica cross-platform e con la sicurezza fornita da una macchina virtuale.
La piattaforma Java permette tutto questo grazie al bytecode Java, un linguaggio intermedio simile al linguaggio macchina in cui vengono compilati i programmi Java, e che viene poi interpretato dalla macchina virtuale.
La libreria ASM è un progetto open source del consorzio OW2--un organizzazione no-profit indipendente--che permette di decomporre, modificare e ricomporre bytecode Java.
È una libreria orientata alla performance, pensata per essere veloce e compatta,
ed usata in progetti come i compilatori dei linguaggi Groovy e Kotlin e il sistema di build Gradle, diventando di fatto lo standard per la modifica di bytecode.
Lo scopo di questa libreria è l'analisi, la trasformazione e la generazione di classi Java compilate. Per fare questo fornisce due API, la core API event based. basata sugli eventi, e la tree API object based, basata sugli oggetti.
La core API sfrutta il pattern Visitor, evitando di rappresentare tutta la classe come albero, permette di utilizzare molta meno memoria, ma il suo utilizzo può risultare più difficile dell'approccio ad oggetti della tree API.
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Lobato, Mario Celso Candian. "Arcabouço de compilação para linguagens de especificação ASM". Universidade Federal de Minas Gerais, 2006. http://hdl.handle.net/1843/RVMR-6QGRMT.
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The ACOA framework is a framework for implementing compilers. The ACOA automatically builds lexer, parser and classes of abstract syntax tree nodes (AST) and uses Aspect-Oriented Programming to implement semantics analysis and code generation. The objective of the ACOA is to be of easy use for implementing compilers and to allow easy alterations in the compilers implemented by means of the framework.O arcabouço ACOA é um arcabouço para implementar compiladores. O ACOA gera automaticamente o analisador léxico, o sintático e as classes dos nodos da árvore de sintaxe abstrata (AST) e usa a programação orientada por aspectos para a implementação da análise semântica e geração de código. O objetivo do ACOA é ser de fácil utilização para a construção de compiladores e permitir fáceis alterações nos compiladores implementados pelo arcabouço.
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Wallander, Bo L. "Electronic countermeasures (ECM) and acoustic countermeasures (ACM) supported protection for merchant ships against SSM/ASM missiles and mines". Thesis, Monterey, California. Naval Postgraduate School, 1989. http://hdl.handle.net/10945/25895.
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Approved for public release; distribution unlimitedThe necessity for merchant ship self protection has become more and more obvious during recent years. This thesis will investigate the threat (missiles and mines) and associated counter-measures that might be installed to provide a reasonable degree of protection. The results indicate that it is possible to get protection against a sea-skimming missile with a combination of ECM and ESM deployed aboard the ship. For protection against the mine threat, a sonar is designed in order to give the ship enough warning time to make an avoiding maneuver. The sonar investigation indicates the difficulty in designing a sonar that can fulfill all design objectives year-round in a complex acoustic environment
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Amaya, Maldonado Sergio. "Efficient analysis of 2D antenna arraysusing the ASM-MBF method". Thesis, KTH, Elektroteknisk teori och konstruktion, 2011. http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-40698.
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The analysis of large-scaled 2D finite planar arrays with the Method of Momentsrelying on the RWG basis functions requires a huge amount of memory for saving theequation system and a long computation time for solving the surface current distribu-tion. In this project, the Array Scanning Method - Macro Basis Function (ASM-MBF)method created by Craeye is implemented in an existing MoM’s code in order to verifythe reduction of the equation system keeping a good accuracy. Some improvementshave been implemented in the existing code in order to analyze arrays with rectangularand skew lattices. The time spent in the impedance matrix construction has also beenreduced. A program for solving 2D infinite arrays has been created for obtaining theinfinite surface current distributions necessary for the implementation of the ASM-MBF method. Finally, the definitive program has been tested with arrays of dipoleand bowtie antennas. In both cases, the computation time is reduced without affectingthe accuracy of the input impedance.
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Shivamoggi, Vasudha B. "X-ray periodicities in sources observed by the RXTE ASM". Thesis, Massachusetts Institute of Technology, 2005. http://hdl.handle.net/1721.1/32909.
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Thesis (S.B.)--Massachusetts Institute of Technology, Dept. of Physics, 2005.Includes bibliographical references (p. 49-50).
The X-ray intensities measured from 230 X-ray sources observed by the RXTE All-Sky Monitor (ASM) were analyzed for periodic behavior. The ASM has been observing sources for nine years in the 1.5-12 keV energy range. In this search, we investigated a frequency range of 5 d⁻¹ to 144 d⁻¹ for periodic modulation. The search was carried out by applying the Fast Fourier Transform on the ASM data and whitening the resulting power density spectrum using a local averaging technique. A power threshold was set to determine the statistical significance of a peak in the power density spectrum. The search verified the orbital frequencies of four known X-ray binaries and also identified four previously unreported periodicities. The 5.7232 d⁻¹ orbital frequency of GX 9+9 was observed for the first time in ASM data, although this modulation had been observed before. The 6.0999 d⁻¹ peak found for XTE J1723-376 has not been reported before and may be an orbital frequency.
y Vasudha B. Shivamoggi.
S.B.
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Hogstrom, Christopher y Christopher Nash. "LOCATING AND REMOVING A PREAMBLE/ASM SEQUENCE IN AERONAUTICAL TELEMETRY". International Foundation for Telemetering, 2016. http://hdl.handle.net/10150/624258.
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This paper describes how to locate and remove periodically inserted preamble and ASM bit fields
in the presence of the phase ambiguity caused by decision-directed PLLs used in most telemetry
demodulators. The phase ambiguity is resolved by correlating rotated or delayed versions of the
data with a stored template of the preamble and ASM bits. A finite state machine in conjunction
with a FIFO is used to remove the preamble and ASM bits from the output bit stream.
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CUNHA, GUILHERME CARVALHO. "REAL TIME EMOTION RECOGNITION BASED ON IMAGES USING ASM AND SVM". PONTIFÍCIA UNIVERSIDADE CATÓLICA DO RIO DE JANEIRO, 2013. http://www.maxwell.vrac.puc-rio.br/Busca_etds.php?strSecao=resultado&nrSeq=23195@1.
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PONTIFÍCIA UNIVERSIDADE CATÓLICA DO RIO DE JANEIROCOORDENAÇÃO DE APERFEIÇOAMENTO DO PESSOAL DE ENSINO SUPERIOR
PROGRAMA DE EXCELENCIA ACADEMICA
As expressões faciais transmitem muita informação sobre um indivíduo, tornando a capacidade de interpretá-las uma tarefa muito importante, com aplicações em diversas áreas, tais como Interação Homem Máquina, Jogos Digitais, storytelling interativo e TV/Cinema digital. Esta dissertação discute o processo de reconhecimento de emoções em tempo real usando ASM (Active Shape Model) e SVM (Support Vector Machine) e apresenta uma comparação entre duas formas comumente utilizadas na etapa de extração de atributos: faces neutra e média. Como não existe tal comparação na literatura, os resultados apresentados são valiosos para o desenvolvimento de aplicações envolvendo expressões de emoção em tempo real. O presente trabalho considera seis tipos de emoções: felicidade, tristeza, raiva, medo, surpresa e desgosto.
The facial expressions provide a high amount of information about a person, making the ability to interpret them a high valued task that can be used in several fields of Informatics such as Human Machine Interface, Digital Games, interactive storytelling and digital TV/Cinema. This dissertation discusses the process of recognizing emotions in real time using ASM (Active Shape Model) and SVM (Support Vector Machine) and presents a comparison between two commonly used ways when extracting the attributes: neutral face and average. As such comparison can not be found in the literature, the results presented are valuable to the development of applications that deal with emotion expression in real time. The current study considers six types of emotions: happiness, sadness, anger, fear, surprise and disgust.
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Castro, Renata da N??brega Souza de. "Correla????o entre a for??a de preens??o manual e a for??a da musculatura respirat??ria em mulheres asm??ticas e n??o asm??ticas". Universidade Cat??lica de Bras??lia, 2009. https://bdtd.ucb.br:8443/jspui/handle/tede/2281.
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Asthma is a chronic inflammatory disease characterized for hiperesponsivity of airflow and imposes boundaries to patient daily activities, interfering in leisure, work and in daily life activities. The weakness of respiratory muscles hazards lung effectiveness and manovacuometry is the specific technique used to evaluate respiratory muscle strength. Handgrip strength has been used as an indicator of functional integrity and total body strength. This study aimed to make a correlation between respiratory muscle strength, hand-grip strength and asthma seriousness in ill and healthy people. This research is classified as a transversal study and the sample was composed by 80 women, from which 40 were asthmatic and 40 were healthy. The hydraulic hand dynameters, Chattanooga?? brand, was used to measure hand-grip strength and the manovacuometry, Suporte?? brand, was used to measure respiratory muscle strength. In order to make the statistical analysis, p 0,05 value was used. Results: hand-grip strength was lower in dominant hand of both groups and the asthmatic women had less respiratory muscle strength. These differences can be considered statistically significant. It was also verified that as more serious is the asthma, lower is the hand-grip strength, although with no statistical significance. The linear regression analysis showed that hand-grip strength can predict respiratory muscle strength. The results of this study indicate that the use of hand-grip strength evaluation is a trustable technique to measure the risks of these patients to present functions limitations.
A asma ?? uma doen??a inflamat??ria cr??nica caracterizada por hiperresponsividade das vias a??reas e imp??e limita????es ao cotidiano do paciente, interferindo no lazer, trabalho e nas atividades de vida di??ria. A fraqueza dos m??sculos respirat??rios prejudica a efic??cia pulmonar, e a manovacuometria ?? a t??cnica espec??fica utilizada para avaliar a for??a muscular respirat??ria (FMR). A for??a de preens??o manual (FPM) vem sendo utilizada como indicador de integralidade funcional e for??a total do corpo. O presente estudo teve como objetivo correlacionar FPM com FMR e gravidade da asma, em indiv??duos com e sem a doen??a. O estudo foi do tipo transversal e a amostra foi composta por 80 mulheres, sendo 40 asm??ticas e 40 n??o-asm??ticas. Foi utilizado o dinam??metro hidr??ulico de m??o da marca Chattanooga?? para a mensura????o da FPM e o manovacu??metro da marca Suporte?? para aferir a FMR. Para a an??lise estat??stica foi adotado p 0,05. Resultados: a FPM foi menor na m??o dominante para ambos os grupos e as asm??ticas apresentaram menor FPM, essas diferen??as foram estatisticamente significantes.Verificou-se tamb??m que quanto maior a gravidade da asma menor a FPM, por??m sem signific??ncia estat??stica. A an??lise de regress??o linear mostrou que a partir da FPM pode-se inferir a FMR. Os resultados do presente estudo indicam utilizar de forma confi??vel a avalia????o da preens??o manual com intuito de inferir o risco destes pacientes apresentarem limita????es de funcionalidade.
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de, Carvalho Melo Silvana. "Estrutura, petrologia e geocronologia do batólito brejo da Madre de Deus (Estado de Pernambuco), relações com a zona de cisalhamento Pernambuco Leste, Nordeste Brasil". Universidade Federal de Pernambuco, 2002. https://repositorio.ufpe.br/handle/123456789/6585.
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Previous issue date: 2002Conselho Nacional de Desenvolvimento Científico e Tecnológico
O batólito Brejo da Madre de Deus (BBMD) representa a porção central do batólito cálcio alcalino de alto potássio Caruaru-Arcoverde, localizado na porção centro-leste do Estado de Pernambuco. Ele intrude dominantemente ortognaisses graníticos a dioríticos e é constituído por três fácies: anfibólio biotita monzogranito a sienogranito grosso a porfirítico, anfibólio biotita sienogranito equigranular médio e quartzo diorito. A fácies porfirítico é dominante sendo intrudido pela fácies equigranular e apresentando feições de contemporaneidade com a fácies diorítico. Estudos de campo e de anisotropia de susceptibilidade magnética mostram que as tramas magmática e magnética são semelhantes, com foliações de direção preferencial EW a NE-SW e mergulhos suaves a moderados. Na porção sul a foliação magmática é superimposta por uma foliação milonítica dada pela zona de cisalhamento Pernambuco. Nas três fácies, os valores de K2ONa2O são maiores que um; os padrões de elementos terras raras (ETR) mostram enriquecimento de ETR leves em relação aos pesados e discretas anomalias negativa de Eu; e spiderdiagrams de elementos traço exibem depressões de Ba, Nb, Sr e Ti. Estas características sugerem magmatismo de subducção, porém como na área de estudo não existem evidencias desse processo, elas devem ter sido herdadas de eventos magmáticos pretéritos. Datações pelo método Pb-Pb em monozircão indicam idades médias de 5915 Ma e 5835 Ma para a fácies porfirítico e equigranular, respectivamente, corroborando os dados de campo. Os ortognaisses apresentaram idades que variam de 2070 Ma a 2090 Ma, tanto na porção norte como no sul, sugerindo que o BBMD não se alojou no limite de terrenosO BBMD apresenta caráter metaluminoso, teores de sílica em torno 70% para a fácies equigranular médio, 65 a 72% para a fácies porfirítico de 51 a 59% para a fácies máfico. A fácies grossa a porfirítico é cedo tectônico à atuação da zona de cisalhamento Pernambuco leste, e a fácies equigranular não apresentam deformação tectônica
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Dumitru, Claudia-Alexandra. "Regulation function of acid sphingomyelinase (ASM) and ceramide in TRAIL-induced apoptosis". [S.l.] : [s.n.], 2006. http://deposit.ddb.de/cgi-bin/dokserv?idn=985789298.
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Margolis, Michael Martin. "The Isolated Human Bone From Grasshopper Pueblo (AZ P:14:1[ASM])". Thesis, The University of Arizona, 2007. http://hdl.handle.net/10150/193280.
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This paper presents research on isolated human remains from Grasshopper Pueblo and analyzes the processes by which bone becomes displaced from burials. Isolated human bone has never been systematically examined, which represents a significant gap in the study of the prehistoric American Southwest. This research is important because it is the first determination of the pattern of isolated bone found at an archaeological site and the formation processes that are responsible. It is also relevant for the creation of a standard isolated bone methodology and because it enables a better understanding of burial assemblages and anomalous assemblages of culturally modified bone.Subadults dominate the assemblage and larger elements are better represented than smaller elements. Most of the modifications present are postmortem but perimortem breakage and toolmarks are also present. This research produced a baseline of detailed data on isolated human bone in which patterns and anomalies can be inferred; the results suggest multiple causes of the isolation of the specimens, including prehistoric cultural disturbance, rodent disturbance, and the process of excavation.
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Tabaud, Anne-sophie. "Le magmatisme des Vosges : conséquence des subductions paléozoïques (datation, pétrologie, géochimie, ASM)". Phd thesis, Université de Strasbourg, 2012. http://tel.archives-ouvertes.fr/tel-00755354.
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Les Vosges sont caractérisées par la présence de nombreuses intrusions et extrusions magmatiques d'affinités variées. Elles constituent donc un excellent site d'étude pour contraindre, par la datation et la géochimie, l'évolution des évènements de ce segment de l'orogène Varisque. Ce travail révèle ainsi deux successions d'évènements magmatiques identiques, décalées dans le temps, caractérisent les domaines Moldanubien (360 à 320 Ma) et Saxothuringien (335 à 295 Ma). Ces successions d'évènements magmatiques résultent de deux processus majeurs. L'avancée des croûtes continentales subduites et sous-plaquées au niveau du Moho sous les blocs continentaux permet le passage du magmatisme calco-alcalin au magmatisme calco-alcalin riche en potassium. L'apport de chaleur par désintégration des éléments radiogéniques (K, U et Th) présents dans ces croûtes continentales subduites permet, dans un premier temps, la formation du magmatisme magnésio-potassique en profondeur. Dans un second temps, elle permet la formation du magmatisme d'origine crustale par l'intrusion du magmatisme magnésio-potassique, riche en K, U et Th, à la limite croûte moyenne - croûte supérieure. Ces successions d'évènements magmatiques et particulièrement, la présence des granites magnésio-potassiques, relient clairement les Vosges à la partie Est de l'orogène Varisque (Forêt Noire, Massif de Bohème, Alpes et Corse-Sardaigne).
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Tabaud, Anne-Sophie. "Le magmatisme des Vosges : conséquence des subductions paléozoïques (datation, pétrologie, géochimie, ASM)". Thesis, Strasbourg, 2012. http://www.theses.fr/2012STRAH003/document.
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Les Vosges sont caractérisées par la présence de nombreuses intrusions et extrusions magmatiques d’affinités variées. Elles constituent donc un excellent site d’étude pour contraindre, par la datation et la géochimie, l’évolution des évènements de ce segment de l’orogène Varisque. Ce travail révèle ainsi deux successions d’évènements magmatiques identiques, décalées dans le temps, caractérisent les domaines Moldanubien (360 à 320 Ma) et Saxothuringien (335 à 295 Ma). Ces successions d’évènements magmatiques résultent de deux processus majeurs. L’avancée des croûtes continentales subduites et sous-plaquées au niveau du Moho sous les blocs continentaux permet le passage du magmatisme calco-alcalin au magmatisme calco-alcalin riche en potassium. L’apport de chaleur par désintégration des éléments radiogéniques (K, U et Th) présents dans ces croûtes continentales subduites permet, dans un premier temps, la formation du magmatisme magnésio-potassique en profondeur. Dans un second temps, elle permet la formation du magmatisme d’origine crustale par l’intrusion du magmatisme magnésio-potassique, riche en K, U et Th, à la limite croûte moyenne - croûte supérieure. Ces successions d’évènements magmatiques et particulièrement, la présence des granites magnésio-potassiques, relient clairement les Vosges à la partie Est de l’orogène Varisque (Forêt Noire, Massif de Bohème, Alpes et Corse-Sardaigne)The Vosges Mountains are characterized by the presence of numerous magmatic intrusions and extrusions of varied affinities. Accordingly, they constitute the best site to investigate, by dating and geochemistry, the evolution of the events affecting this segment of the Variscan orogeny. Two successions of identical magmatic events, shifted in the time, are identified, characterizing both Moldanubian (360 to 320 Ma) and the Saxothuringian (335 to 295 Ma) domains. These successions of magmatic events result of two major process. The progress of subducted and underplated continental crusts at Moho depth under continental blocks permits to shift from calc-alkaline to high potassic calc-alkaline magmatism. The radiogenic heat production from latter underplated continental crusts, in a first time, permits to generate magnesio-potassic magmas at depth. Then, this radiogenic heat permits to generate crustal magmas by intrusion of magnesio-potassic magmas rich in K, U and Th at mid-upper crust boundarie. These successions of magmatic events and particularly, the presence of the magnesio-potassic granites, imply a strong link between the Vosges Mts. and the eastern part of the Variscan orogeny (Black Forest, Bohemian Massif, the Alps and Corsica Batholith)
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Lopes, Renan Garcia. "Geologia da região de Colatina (ES): Uma abordagem geocronológica, petrográfica e estrutural por ASM". Universidade de São Paulo, 2016. http://www.teses.usp.br/teses/disponiveis/44/44141/tde-28092016-144705/.
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A porção leste do Orógeno Araçuaí, de idade neoproterozoica, compreende uma extensa área composta por anatexitos, leucogranitos, kinzigitos e granulitos migmatizados, que provavelmente estão correlacionados com o registro de uma ampla fusão parcial da crosta intermediária a inferior. Na região de estudo afloram rochas do Complexo Nova Venécia, que é caracterizado por ortogniasses e, sua paragênese é dada pela associação entre cordierita + granada + biotita + feldspato potássico + plagioclásio + quartzo e, a presença de sillimanita indica que estas rochas chegaram a fácies anfibolito superior. São rochas que variam de metatexitos a diatexitos com ampla variação das estruturas de fusão parcial. A mineralogia observada no ortognaisse é praticamente a mesma encontrada no granitoide Colatina - aflorante na região, com exceção dos minerais metamórficos cordierita e sillimanita, observadas pontualmente na região de estudo. Com relação à deformação na região de estudo, nota-se que esta deu-se de forma contínua, indo desde o estágio pré-colisional até o pós-colisional, estando o registro desta, tanto no bandamento gnáissico, quanto na anisotropia de suscetibilidade magnética (ASM) e nos cristais de plagioclásio deformados observados no Norito, que possui ocorrência restrita na área. A mineralogia magnética é dada principalmente minerais ferromagnéticos oblatos, sendo estes a magnetita e em menores proporções a pirrotita e maghemita, podendo também ter influência de minerais paramagnéticos como a biotita. Foram identificadas duas fases deformacionais, a primeira relacionada ao metamorfismo que gerou o bandamento gnáissico e migmatítico e a segunda relacionada ao dobramento identificado nos estereogramas de alguns domínios estruturais e à foliação observada no granitoide. Com relação à geocronologia, foi obtida a idade de 582,9 ±4,1Ma para a rocha fonte que gerou os sedimentos que deram origem ao ortognaisse. Idade essa muito próxima à de 576,3 ±2,9Ma obtida para o granitoide Colatina, relacionada a sua cristalização, indicando que provavelmente ambas as rochas - a rocha fonte dos sedimentos que deram origem ao ortognaisse e o granitoide Colatina - foram geradas em um mesmo evento, sendo que o pulso magmático que gerou a rocha fonte dos sedimentos do ortognaisse possui caráter pré-colisional e o granitoide Colatina sin-colisional. Nas bordas de sobrecrescimento dos zircões do ortognaisse foi obtida a idade de 522 ±2Ma, sendo esta atribuída ao último evento metamórfico que atuou na região. Razões Th/U mostram que a origem dos zircões analisados do ortognaisse (núcleo dos zircões) é magmática, sendo essa de aproximadamente 0,42 no núcleo dos zircões e de 0,15 nas regiões de borda de sobrecrescimento, indicando serem estas bordas de sobrecrescimento metamórfico. A idade obtida em monazitas do ortognaisse foi de 503 ±4Ma e, de acordo com a temperatura atingida durante o pico metamórfico (820°C, calculada por Munhá et al. 2005), indica que esta idade relaciona-se também ao último evento metamórfico, visto que a temperatura de fechamento da monazita é de cerca de 750°C. Com a idade metamórfica obtida nas bordas de sobrecrescimento do zircão e na monazita, calcula-se uma taxa de resfriamento de aproximadamente 3,7°C/Ma para a região. Por fim, a idade obtida para o norito foi de 513,2 ±2,3Ma, sendo este associado ao estágio pós colisional, estando a deformação registrada em cristais de plagioclásio deformados observados na análise microestrutural.The eastern portion of the Araçuaí Belt, Neoproterozoic age, comprises a large area consisting of anatexites, leucogranites, kinzigites and migmatized granulites, that probably are related with the registration of an extensive partial melting of the middle and lower crust. In the region of this study, there are rocks from de Nova Venécia Complex, that is characterized by ortognesis and, the paragenesis is given by the association cordierite + garnet + biotite + potassium feldspar + plagioclase + quartz and, the presence of sillimanite indicates that these rocks reached upper amphibole - granulite facies. The migmatites range from metatexites to diatexites with wide variation in partial melting structures. The mineralogy observed in these rocks is almost the same found in the Colatina granitoid, with the exception of the metamorphic minerals as cordierite and sillimanite, that were observed in a specific outcrop. Regarding the deformation in the study region, it was performed continuously, going from pre-collisional to post-collisional stage, recorded in the gneissic banding and in the granitoid, also the weak deformation observed in the plagioclase crystals of the norite. The magnetic mineralogy is given mainly ferromagnetic oblate minerals, which are magnetite and to a lesser extent the pyrrhotite and maghemite, it can also have influence of paramagnetic minerals such as biotite. Two deformational stages have been identified, the first one was related to the metamorphism that generated the gneissic and migmatitic banding, and the second, associated to the folding pattern identified in stereograms of some structural domains and in the foliation observed in granitoid. Geochronological data show the age of 582.9 ± 4.1Ma as the age of the source rock that generated the sediments that gave rise to the paragneisses of the Nova Venécia Complex. This age is close to the 576.3 ±2.9Ma obtained for the Colatina granitoid, related to its crystallization, indicating that probably both rocks - the source rock of the sediments and Colatina granitoid were generated at the same tectonic event. These data suggest that the magmatic pulse that generated the source rock of the paragneisses sediments and Colatina granitoid have, respectively, pre-collisional syn-collisional characteristics. The U/Pb analysis in the edges of the zircons show the age of 522 ± 2Ma, that can be attributed to the last metamorphic event who acted in the region. The ratios Th/U show that the origin of the analyzed zircons (zircon core) is magmatic, with the average value of 0.42 in the core of zircon and 0.15 regions in the edges, thus indicating that they were due to a metamorphic event. The 503 ± 4Ma age obtained from the monazite crystals was assigned to the temperature reached during the metamorphic peak (820°C, measured by Munha et al. 2005), indicates that this age can be also related to the last metamorphic event, since the temperature closing system of the monazite is about 750°C. The relationship of these ages and the metamorphic temperatures allow to estimate a cooling rate of about 3.7°C/Ma. Finally, the norite age of 513.2 ± 2.3Ma, can be associated with the final collisional stage, as shown by the deformation recorded in plagioclase crystals observed in the microstructural analysis.
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Kopřiva, Adam. "Rozpoznání obličeje". Master's thesis, Vysoké učení technické v Brně. Fakulta informačních technologií, 2010. http://www.nusl.cz/ntk/nusl-237264.
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This master's thesis considers methods of face recognition. There are described methods with different approachs: knowledge-based methods, feature invariant approaches, template matching methods and appearance-based methods. This master's thesis is focused particulary on template matching method and statistical methods like a principal component analysis (PCA) and linear discriminant analysis (LDA). There are described in detail template matching methods like active shape models (ASM) and active appearance models (AAM).
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Nikkinen, Viktoria y Eva-Lotta Thörngren. "Kommunikationens betydelse för samspelet mellan identitet och image : En fallstudie av ASM Foods AB". Thesis, Linköpings universitet, Företagsekonomi, 2012. http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-78750.
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Syfte: Syftet med vår studie är att undersöka kommunikationens betydelse för samspelet mellan identitet och image och hur detta uppfattas av ledning, medarbetare, kunder och agenter. Referensram: Vi har i denna studie beskrivit vad identitet är utifrån bland annat Balmer och Greysers (2002) teori om multipla identiteter. Vidare tillämpas teorier kring intern kommunikation och intern marknadsföring för att belysa deras betydelser för den interna bilden. Utöver denna interna bild beskriver vi även vad image är och vilken betydelse den integrerade marknadskommunikationen har för dess uppfattning. Empiri: Vår empiri baseras på en semi-strukturerad intervju med en person ur ASMs ledningsgrupp samt enkätstudier med medarbetare, kunder och agenter. Vi har även studerat företagets hemsida. Slutsats: Vi kommer fram till att ASMs identitet överensstämmer med ASMs image. Företaget har en väl fungerande extern kommunikation, men uppvisar interna brister i kommunikationen.
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Marquer, Yoann. "Caractérisation impérative des algorithmes séquentiels en temps quelconque, primitif récursif ou polynomial". Thesis, Paris Est, 2015. http://www.theses.fr/2015PESC1121/document.
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Les résultats de Colson ou de Moschovakis remettent en question que le modèle récursif primitif puisse calculer une valeur par tous les moyens possibles : il y a toutes les fonctions voulues mais il manque des algorithmes. La thèse de Church exprime donc plutôt ce qui peut être calculé que comment le calcul est fait. Nous utilisons la thèse de Gurevich formalisant l'idée intuitive d'algorithme séquentiel par les Abstract States Machines (ASMs).Nous représentons les programmes impératifs par le langage While de Jones, et une variante LoopC du langage de Meyer et Ritchie permettant de sortir d'une boucle lorsqu'une condition est remplie. Nous dirons qu'un langage caractérise une classe algorithmique si les modèles de calcul associés peuvent se simuler mutuellement, en utilisant une dilatation temporelle et un nombre borné de variables temporaires. Nous prouvons que les ASMs peuvent simuler While et LoopC, que si l'espace est primitif récursif alors LoopC est en temps récursif primitif, et que sa restriction LoopC_stat où les bornes des boucles ne peuvent être mises à jour est en temps polynomial. Réciproquement, une étape d'ASM peut être traduite par un programme sans boucle, qu'on peut répéter suffisamment en l'insérant dans un programme qui est dans While si la complexité est quelconque, dans LoopC si elle est récursif primitif, et dans LoopC_stat si elle est polynomiale.Ainsi While caractérise les algorithmes séquentiels en temps quelconque, LoopC ceux en temps et espace récursifs primitifs, et LoopC_stat ceux en temps polynomialColson and Moschovakis results cast doubt on the ability of the primitive recursive model to compute a value by any means possible : the model may be complete for functions but there is a lack of algorithms. So the Church thesis express more what can be computed than how the computation is done. We use Gurevich thesis to formalize the intuitive idea of sequential algorithm by the Abstract States Machines (ASMs).We formalize the imperative programs by Jones' While language, and a variation LoopC of Meyer and Ritchie's language allowing to exit a loop if some condition is fulfilled. We say that a language characterizes an algorithmic class if the associated models of computations can simulate each other using a temporal dilatation and a bounded number of temporary variables. We prove that the ASMs can simulate While and LoopC, that if the space is primitive recursive then LoopC is primitive recursive in time, and that its restriction LoopC_stat where the bounds of the loops cannot be updated is in polynomial time. Reciprocally, one step of an ASM can be translated into a program without loop, which can be repeated enough times if we insert it onto a program in While for a general complexity, in LoopC for a primitive recursive complexity, and in LoopC_stat for a polynomial complexity.So While characterizes the sequential algorithms, LoopC the algorithms in primitive recursive space and time, and LoopC_stat the polynomial time algorithms
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Hung, Wing Yee [Verfasser] y Erich [Akademischer Betreuer] Gulbins. "The characterization of immune cells in Asm-overexpressed mice / Wing Yee Hung ; Betreuer: Erich Gulbins". Duisburg, 2019. http://d-nb.info/1177681765/34.
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Hart, Sharlot Marie Dunfield. "Defining Site Boundaries: A Case Study at University Indian Ruin, AZ BB:9:33(ASM)". Thesis, The University of Arizona, 2015. http://hdl.handle.net/10150/594370.
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University Indian Ruin (UIR), which sits in the eastern Tucson Basin, is a prime example of a Classic Period Hohokam platform mound archaeological site. The University of Arizona owns 13 acres of this site, and it is listed on the National Register of Historic Places using this acreage as its site boundary. However, multiple investigations have shown that the site is not fully contained within that boundary. This work seeks to answers to two questions about the UIR site. The first is to further investigate to duration of occupation at UIR, beyond the Classic Period. The second is to systematically investigate the extent of UIR into the surrounding residential community. Results include a new, proposed boundary for management by Pima County and the State of Arizona. How archaeologists define a site boundary is also investigated.
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Martínez, Jiménez María Guadalupe. "Segmentación del hipocampo en imágenes de resonancia magnética utilizando un modelo de forma activa". Tesis de maestría, UAEM, 2020. http://hdl.handle.net/20.500.11799/109996.
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Actualmente, el uso de las imágenes médicas tiene impacto en el área clínica, gracias a que el desarrollo científico y tecnológico permite a los médicos hacer un análisis y diagnóstico para distintas patologías del cerebro y otras estructuras anatómicas.
La segmentación del área del hipocampo es de interés en el área médica, debido a que se considera un biomarcador para el diagnóstico de patologías neurológicas y psiquiátricas, incluyendo enfermedad de Alzheimer (EA), epilepsia y esquizofrenia (Dill et al., 2015; Boccardi et al., 2015), así como para revelar las diferencias anatómicas (atrofia) de personas, debido al envejecimiento o la demencia (Kim et al., 2013), su anatomía puede ser analizada con neuroimágenes médicas, por ejemplo, las imágenes de resonancia magnética (IRM). Dicha segmentación de la estructura anatómica puede ser de forma manual, semiautomática o automática.
En esta tesis se evalúa un método para la segmentación de la forma del hipocampo en imágenes de resonancia magnética, utilizando un modelo de forma activa (ASM, por sus siglas en inglés Active Shape Model), el cual es utilizado en dos etapas: entrenamiento y ajuste. En la etapa del entrenamiento de ASM se utiliza un conjunto de imágenes segmentadas manualmente que sirven para formar un modelo de distribución de puntos (MDP), donde cada forma es representada por un conjunto de puntos que describen el borde de una estructura. Por otra parte, la etapa de ajuste consiste en segmentar nuevas formas en el que se analizan los niveles de gris alrededor de cada punto de referencia de la forma.
Además, se utiliza una métrica de distancia (distancia euclidiana) con la que se mide la distancia entre los puntos de la segmentación manual y la segmentación ajustada con ASM para obtener los errores de ajuste.
El modelo de forma activa fue construido con 41 imágenes de resonancia magnética tomadas de la base de datos Alzheimer’s Disease Neuroimagen Initiative (ADNI), de la Universidad del Sur de California (University, 2020). Las imágenes del conjunto de entrenamiento fueron marcadas con 30 puntos de referencia, dado que el hipocampo es una estructura anatómica cuya dimensión es de 4 a 4.5 cm de longitud y de 1 a 1.5 cm de ancho (Duvernoy, 2013).
Se presenta una experimentación para validar el nivel de ajuste del modelo de forma activa, previo a una consistente revisión literaria del estado del arte. La experimentación de ajuste se realiza utilizando la técnica leave one out. En dicha experimentación se obtiene un error de ajuste medio de 1.85 mm, el cual está por debajo del máximo error permisible (2 mm) en diagnósticos clínicos (Yue et al., 2006), lo cual indica que son resultados aceptables.
Por otra parte, se obtuvo el coeficiente de similitud de Dice (DSC, por sus siglas en inglés Dice Similarity Coefficient) para cuantificar la precisión de la segmentación. El resultado del DSC medio es de 62 %, lo cual indica un resultado por debajo del valor aceptable que es de 80%.PNPC CONACYT
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Mack, Inocentio Damien. "Condition physique et santé : du diagnostic à l'activité physique personnalisée chez le senior (ASM Vitaly Test)". Thesis, Université Clermont Auvergne (2017-2020), 2019. http://www.theses.fr/2019CLFAC054.
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L'objectif de la thèse était de créer et de tester un dispositif d'évaluation de la condition physique afin de permettre une reprise d'activité physique pour des personnes en bonne santé. Le dispositif doit permettre de créer une cohorte de sujets suivi dans leur activité physique et leur santé en partenariat avec des associations ou des établissements de soinsThe objective of the thesis was to create and test a fitness assessment tool promoting resume of physical activity for healthy people. The device must make it possible to create a cohort of subjects followed in their physical activity and their health in partnership with associations or health care institutions
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Ležák, Aleš. "Simulační model IPTV služby s protokolem RTP". Master's thesis, Vysoké učení technické v Brně. Fakulta elektrotechniky a komunikačních technologií, 2008. http://www.nusl.cz/ntk/nusl-217546.
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This diploma thesis contains questions of simulation data transfer by ASM multicast. In simulation tool Opnet Modeler is proceed design of service IPTV. IPTV means television which is transfered in network by IP protocol. Data of IPTV service are sending by multicast transfer. Multicast is a technology which uses a group transfer. It is actually communication of a one source of data with many users. These users are receiving the same data. A main target of this technology is to decrement loading of source node and transference system in distribution of data towards group of users. Most often is multicast used in distribution of audiovisual data. Relation RTP/RTCP is simulated with a different numbers of users. Observed is interval of transmission of control RTCP packets. This will be reached by two methods which will be confront in the end. One is a theoretic calculation by course of a equation and second is a practical simulation in Opnet Modeler.
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MARTINEZ, GARCIA CRISTIAN GENARO 207109 y GARCIA CRISTIAN GENARO MARTINEZ. "Proceso de lodo activado de baja produccion de lodo; Mecanismos de reduccion de masa y modelacion". Tesis de doctorado, Universidad Autonoma del Estado de México, 2015. http://hdl.handle.net/20.500.11799/80308.
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El tratamiento y disposición de los lodos residuales de las plantas de tratamiento representa del 25 al 60 % del costo total de su operación, por lo que es importante minimizar las cantidades que se generan en los procesos de tratamiento. Para hacer frente a esta problemática, se están desarrollando e investigando estrategias para disminuir el volumen de lodo residual a disponer, como son el proceso OSA (por sus siglas en inglés Oxic-Settling-Anaerobic) y el proceso “caníbal; en los cuales se coloca un tanque de intercambio (TI) en la línea de recirculación de lodos de la planta de tratamiento (en condiciones anaerobias e hipóxicas, respectivamente) con lo cual, la biomasa alterna entre ciclos aerobios en presencia de sustrato y las condiciones del TI (sin sustrato). Se han realizado diversos estudios comparando la degradación del lodo biológico, empleando diferentes condiciones en los tanques de intercambio, sin embargo, la mayoria comparan dos o tres ambientes diferentes con un mismo tipo de lodo ó dos tipos de lodo bajo una sola condición en el tanque de intercambio. Además, hay muy poca información en la literatura sobre el efecto de los diferentes ambientes de digestión sobre la fracción XP y sobre los mecanismos que ocurren en los mismos. El presente proyecto de tesis tiene como propósito estudiar los efectos de los distintos ambientes (anaerobio, hipóxico, aerobio y aireación intermitente) sobre la reducción de sólidos del reactor de intercambio en un proceso modificado de baja producción de lodos, así como seguir el porvenir de los XP, mediante el uso de la modelación con base en el ASM1 y datos obtenidos en reactores a nivel laboratorio. Con este fin, se generó un lodo-modelo, el cual contenía únicamente las fracciones XH y XP. El lodo fue generado en dos reactores secuenciales barch (SBR) de 30 litros alimentados con agua sintética, la cual tenía como fuente de carbono acetato, con una demanda química de oxígeno (DQO) de 500 mg/L. En la primera fase del estudio, el lodo-modelo fue digerido en condiciones aerobias y monitoreado por un lapso de 140 días, determinando total y soluble (DQOT y DQOs), sólidos suspendidos totales y volátiles (SST y SSV) y realizando mediciones de temperatura y pH. Al final de la corrida, se alcanzó una reducción de 44% en términos de SSV. Los datos obtenidos fueron simulados mediante el modelo del ASM1 en el software Aquasim. La modelación permitió estimar las constantes bH (0.023 d-1), y las tasas DQO/SSV de la biomasa activa (icvH = 1.48) y los residuos endógenos (icvP = 1.06). El valor de bH fue 10 veces menor a lo reportado en la literatura para la biomasa heterótrofa ordinaria tipo OHO (0.2 d-1), por lo cual se consideró que el tipo de biomasa generado fue de tipo acumulador (PAO y/o GAO), lo cual fue comprobado mediante una corrida de cinética de DQOs en paralelo con mediciones de respirometría (rO2). Los valores de icvH e icvP sugieren que para las bacterias acumuladoras, la relación DQO/SSV es diferente para la biomasa activa (icvH) y para la fracción XP (icvP). En la segunda fase, se digirió el lodo-modelo bajo siete diferentes ambientes (anaerobio, aerobio, hipóxico y cuatro reactores intermitentes, 5min-3h, 30min-6h, 2h-10h y 12h-12h), los cuales fueron monitoreados por 120 días determinando DQOT, DQOs, SST, SSV y realizando mediciones de temperatura, potencial de oxido reducción (ORP) y pH. En este tiempo se alcanzó una reducción promedio del 58% de SSV en los digestores. Se observó que los ambientes hipóxico y el intermitente 5min-3h (5 minutos con aireación, seguido de 3 horas sin aireación) mostraron mayor porcentaje de degradación, lo que indica que el tener condiciones con limitaciones de oxígeno o alternar entre condiciones aerobias y anaerobias favorece más la degradación de la materia orgánica. Los datos de los siete digestores fueron simulados con un modelo que considera el decaimiento de la fracción XP con una constante de decaimiento de primer orden bP. Las constantes de decaimiento bH y bP y las tasas icvH e icvP fueron estimadas. El digestor hipóxico obtuvo las mejores tasa de decaimiento de bH y bP (0.047 y 0.0046 d-1 respectivamente), esto indica que son las mejores condiciones para la digestión de este tipo de lodo-modelo. Los valores de icvH e icvP fueron 0.54 y 0.19 respectivamente, son muy semejantes a los obtenidos en la fase anterior. En la última fase, se tomó licor mezclado de la planta de tratamiento de aguas residuales municipales Toluca-Norte y se digirió bajo los mismos siete ambientes, monitoreando los digestores por 70 días, realizando determinaciones de DQOT, DQOs, SST, SSV y realizando mediciones de temperatura y pH. Para este tipo de lodo, el mayor porcentaje de reducción de masa lo obtuvo el digestor intermitente 12h-12h, reduciendo el 66% de SSV. Al simular los datos con el modelo que considera el decaimiento de la fracción XP, se observó que la mejor tasa de decaimiento bH fue de 0.18 d-1(muy próximo al 0.2 d-1 para la biomasa OHO) en el digestor intermitente 12h-12h. Los datos obtenidos en la fase experimental no proporcionaron suficiente información para determinar un bP para cada ambiente, sin embargo se estimó un bP promedio de 0.035 d-1 para todos los digestores.
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Sans, Soler Marc. "Unattended design of wideband planar filters based on stepped impedance resonators (SIRs) through aggressive space mapping (ASM)". Doctoral thesis, Universitat Autònoma de Barcelona, 2018. http://hdl.handle.net/10803/664688.
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La síntesis de circuitos planares de microondas capaces de satisfacer un conjunto de especificaciones es un tema de interés en la actualidad dentro del campo de la ingeniería de microondas. A pesar de que la mayoría de las herramientas software de diseño asistido y los simuladores electromagnéticos disponibles en el mercado incluyen optimizadores, obtener la topología del circuito que cumple con las especificaciones es generalmente complicado. La convergencia a la solución óptima no está siempre garantizada a no ser que el layout inicial sea muy próximo al que ya proporciona la respuesta objetivo y la experiencia del diseñador juega un papel clave en este proceso de optimización a medida que la complejidad del circuito aumenta.
Por otro lado, los filtros de microondas single-ended y, más concretamente, los filtros de microondas balanceados, se han convertido en dispositivos esenciales debido a los recientes avances en el desarrollo de las tecnologías de comunicación modernas, dónde elevados niveles de integración y sistemas más complejos son requerimientos fundamentales. Por lo tanto, un proceso sistemático capaz de proporcionar el layout del filtro que cumple con las especificaciones requeridas sería muy bien recibido para la comunidad de los ingenieros de microondas.
Esta tesis está orientada a la síntesis automática de filtros de microondas planares single-ended y balanceados que proporcionan respuestas pasa banda y de banda ancha. Estas estructuras se basan en elementos resonantes semi-concentrados, implementados mediante una combinación de secciones de líneas de transmisión de alta y baja impedancia, más conocidos como Resonadores de Salto de Impedancia (SIRs). La estrategia de optimización, basada en la técnica de Aggressive Space Mapping (ASM), tiene el objetivo de generar el layout del filtro que satisface las especificaciones siguiendo un proceso totalmente desasistido. De este modo, este método de síntesis automática puede dar lugar a la implementación de una herramienta de optimización asociada a este tipo de filtros basados en SIRs, adecuada para ser incorporada en cualquier software existente en el mercado dedicado al diseño de dispositivos de microondas
Con este propósito, algoritmos basados en ASM son desarrollados en esta tesis para la síntesis automática de distintas topologías de filtros de microondas single-ended y balanceados basados en SIRs. Los procedimientos para el diseño automático de éstos dispositivos son descritos en detalle y su funcionalidad es validada mediante su aplicación a la generación de distintos layouts destinados a satisfacer un conjunto particular de especificaciones en cada caso. Los procesos de síntesis automática desarrollados y los resultados obtenidos revelan que esta metodología de optimización puede ser aplicada a muchos otros tipos de filtros, y han conducido a este trabajo de investigación a contribuir en el estado del arte con nuevas estrategias en la formulación del ASM y con innovadoras topologías de filtros pasa banda de banda ancha.The synthesis of planar microwave circuits able to satisfy a set of given specifications has been a subject of interest in the microwave community for years. Despite the fact that most commercially available computer aided design tools and electromagnetic solvers include optimizers, obtaining the circuit topologies that satisfy the design requirements is generally cumbersome. Convergence to the optimum solution is not always guaranteed unless the seeding layout is already very close to the one providing the target response, and designer experience plays a key role in such optimization process as long as the circuit complexity increases. On the other hand, single-ended and, more specially, balanced microwave filters have become essential devices with the recent advances in the development of wireless communication technologies, where higher levels of integration and more complex microwave systems are key requirements. Therefore, a systematic procedure able to provide the filter layout satisfying the required specifications would be very welcomed by microwave engineers. This thesis is focused on the automatic synthesis of single-ended and balanced planar microwave filters providing wideband bandpass responses. Such filter structures are based on semi-lumped resonant elements, implemented by a combination of high and low impedance transmission line sections, also known as Stepped Impedance Resonators (SIRs). The optimization approach, based on the Aggressive Space Mapping (ASM) technique, is aimed to generate the filter layout from design specifications following a completely unattended scheme. Therefore, such filter optimization scheme can represent the first step towards an optimization tool for this type of SIR-based filters suitable to be part of any commercially available engineering software focused on microwave design. To this end, specific ASM-based algorithms are developed in order to automatically synthesize multiple single-ended and balanced filter topologies based on SIRs. The proposed automatic design procedures are thoroughly detailed and validated through its application to generate several filter layouts starting from different sets of practical specifications. The reported procedures and the results obtained reveal that this optimization methodology can be extended to many other filter structures, and have lead this research work to contribute to the state of the art with innovative strategies in the ASM formulation as well as with novel synthesized passband filter topologies.
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Le, Pennec Jean-Luc. "Le developpement de la fabrique vectorielle (opf et asm) dans les roches pyroclastiques : applications volcanologiques en anatolie centrale". Clermont-Ferrand 2, 1994. http://www.theses.fr/1994CLF21638.
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Les proprietes vectorielles des roches pyroclastiques sont utilisees dans ce memoire pour caracteriser leurs processus de mise en place et pour localiser geographiquement la source des nappes d'ignimbrite. Les applications s'adressent a la province volcanique d'anatolie centrale (turquie) et a l'etna (sicile). Une analyse de la fabrique magnetique de l'ignimbrite de kizilkaya montre que l'origine de l'asm est variable dans ce type de roche. L'asm est coaxiale de la fabrique de forme mais les relations entre axes magnetiques et cinematiques sont complexes. Durant l'histoire de la mise en place, l'ignimbrite s'est comportee surtout comme un fluide de type newtonien. Une aggradation par palier est proposee comme mecanisme de depot dans cette unite. La localisation de la source est estimee par plusieurs methodes. L'une est basee sur la densite de recouvrement des eventails d'erreur asm. Une autre est basee sur la recherche du point du plan geographique a partir duquel les donnees directionnelles divergent le moins. Les resultats indiquent que la source est situee au sud-ouest de la ville de derinkuyu. D'autres methodes quantitatives nouvelles sont proposees dans la these. L'etude d'une autre ignimbrite est faite par analyse d'image de photographies prises sur le terrain. On montre que les fragments lithiques noyes dans une matrice cendreuse, developpent une fabrique similaire a celle produite par rotation interrompue de marqueurs rigides plonges dans un fluide visqueux d'inertie importante, soumis a un cisaillement simple lent. Le depot se serait fait en masse dans cette unite. A l'etna, on montre par l'analyse de fonction d'orientation de marqueurs rigides que les produits associes a la caldera du cratere elliptique sont en fait des pyroclastites soudees et non des coulees brechifiees par vesiculation progressive. Une synthese de la geologie des ignimbrites de cappadoce est presentee. Six grandes unites sont reconnues (surface: 2 500 a 10 500 km#2 ; volume: 80 a 300 km#3). Leurs sources sont situees au nord et au sud du massif de l'erdas. En outre, le massif tres fracture de sahinkalesi tepe est une importante structure de soulevement
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Loaiza, Navía Jimmy Luis. "Modelación del Proceso de Lodos Activados en la Planta de Tratamiento de Aguas residuales Noreste, del Área Metropolitana de Monterrey, NL". Tesis de doctorado, Universidad Autónoma del Estado de México, 2007. http://hdl.handle.net/20.500.11799/94531.
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Dentro de los últimos 25 años, uno de los avances más significativos con referencia al conocimiento sobre tratamiento de aguas residuales, es el desarrollo de una serie de modelos dinámicos capaces de simular el comportamiento complejo de los procesos biológicos a escala real de una planta (lodos activados, digestión anaerobia, bio-películas, entre otros). En particular, el modelo de lodos activados N°1 (ASM1, por sus siglas en inglés) ha sido ampliamente utilizado en el mundo, no así en México; cuya aplicación representa oportunidades de ahorros, mejores diseños y desempeño de las plantas del país.
En la presente investigación, se utilizó un enfoque de modelación para estudiar el caso de la Planta Noreste, una de las tres plantas de tratamiento de aguas residuales (PTAR) del área metropolitana de Monterrey, NL, cuyo incremento continuo de flujo, desde su puesta en marcha, derivó en dos ampliaciones mayores en menos de 10 años. La planta, cuya capacidad actual es de 1,250 LPS, utiliza un proceso de lodos activados en cuatro líneas, idénticas dos a dos, formadas por dos reactores centrales alargados (2 x 17,830 m3) de 7 compartimientos cada uno, y dos líneas laterales (2 x 4,640 m3) que tienen cada uno un reactor VLR (variante de zanja de oxidación con circulación vertical del agua) seguido por un tanque de aeración de burbuja fina (BF).
El objetivo principal de la investigación fue modelar, con el ASM1, el proceso de lodos activados de la Planta Noreste, para describir su comportamiento en cuanto a remoción de materia orgánica, nitrógeno y producción de lodo, con el fin de que el modelo calibrado sirva como herramienta de toma de decisión en el futuro.
La metodología utilizada consistió en la integración y puesta en práctica de diferentes estudios intermedios, así como el desarrollo de una secuencia especifica de calibración del modelo, con base a una serie de métodos y recomendaciones dispersadas en la literatura. Los estudios intermedios fueron: caracterización para determinar las fracciones de DQO y nitrógeno del influente, determinación de la estructura del modelo hidráulico de la planta, modelación de la sedimentación y realización de pruebas respirométricas.
Para el estudio de fraccionamiento, se realizó una recopilación y análisis de los datos de rutina, a partir de cuya base, se diseñó y realizó una campaña de muestreo y análisis, a fin de caracterizar el influente y efluente (compuestos de carbono y nitrógeno, total y soluble) y determinar así el fraccionamiento de la DQO y del nitrógeno según los requerimientos y la nomenclatura estandardizada del ASM1 (SS, XS, Si, Xi, SNH, SND, etc). La campaña incluyó la medición de algunos flujos internos en diversas corrientes, la medición de las tasas de consumo de oxígeno, perfiles de oxígeno disuelto, de nitrógeno amoniacal, de nitratos y de temperatura, entre otros. Para el fraccionamiento, se evaluaron dos métodos de cálculo: uno basado en el modelo incluido en el modulo “Influent Advisor” del programa GPS-X, y el otro basado en un modelo conocido en la literatura como “protocolo de caracterización de la STOWA”. En promedio, las fracciones SS, XS, Si y Xi, respecto a la DQO total del influente, fueron respectivamente 17%, 41%, 5%, 37% con el método incluido en el GPS-X, contra 13%, 56%, 4%, 27% con base en el método STOWA. Lo anterior mostró que los dos métodos no son equivalentes. Para mantener la coherencia en el estudio, se optó seguir el trabajo con los resultados procedentes del “Influent-Advisor de GPS-X”.
Otro requisito importante del procedimiento de calibración fue conocer la hidrodinámica de los reactores, por lo que se llevaron a cabo pruebas de trazador con Rhodamina WT. Los datos se analizaron con un enfoque innovador basado en el uso de un simulador (Aquasim), que permitió establecer que el reactor central, diseñado y construido como flujo tipo pistón con 7 celdas, se representa mejor por un modelo virtual de 5 tanques de mezcla completa (CSTR) en serie, el primero (anóxico) de 2,180 m3 y cuatro (aerados) de 3,912.5 m3. Con las pruebas de trazador, se mostró por otro lado, que el reactor lateral, se representa mejor por un arreglo virtual de 3 CSTR’s en serie (uno de 3040 m3 que describe al VLR y dos de 800 m3 que describen al tanque de burbuja fina, más una pequeña recirculación interna de 262 m3/d, del tanque 3 al 1).
En cuanto a la calibración del sedimentador secundario, el estudio permitió determinar los parámetros del modelo de Vesilind (v0 11.5 m/h y n 0.38 m3/kg) a partir de pruebas de sedimentación en columna, y comprobar que son identificables de forma única. Estos datos fueron transferidos luego al programa de calibración del modelo biológico.
Finalmente, para la calibración del modelo biológico, se utilizó el programa GPS-X; la base de datos fue carbón-nitrógeno (cnlib), el modelo biológico fue ASM1 y la opción de modelo de influente fue “CODfractions” (mismo que fue evaluado previamente con “Influent Advisor”). Se desarrolló y aplicó un procedimiento de calibración, que junto a las etapas previas de caracterización del influente, hidrodinámica de los reactores y calibración del sedimentador, consistió en las siguientes fases: Fase cero (estimación de Si con base a DBO y DQO del efluente), Fase uno (transferencia de los parámetros de fraccionamiento en simulador), Fase dos (estimación del volumen de purga QWAS), Fase tres (terminación de la calibración del sedimentador), Fase cuatro (calibración en estado estacionario), Fase cinco (verificación de la calibración en estado estacionario con promedios diarios) y Fase seis (verificación con base a datos dinámicos diurnos). Así mismo se construyó el modelo de la planta completa (cuatro reactores y tres clarificadores) para plantear las aplicaciones del modelo.
El modelo calibrado fue capaz de describir de forma adecuada la calidad del efluente (carbono y nitrógeno) y la producción del lodo, en especial en estado estacionario. Por lo que se considera exitosa la secuencia de calibración desarrollada y puesta en práctica en el proyecto, y que presenta una contribución al esfuerzo internacional de estandardización de los procedimientos de calibración del ASM1.
Los resultados obtenidos de la aplicación del modelo calibrado sugieren que se podría dejar fuera de operación al menos un reactor VLR, en el verano, sin afectar el desempeño de la planta. En el futuro, se recomienda incluir el proceso de aeración en la modelación, así como otra campaña de muestreo que permita complementar y verificar la calibración del modelo en régimen dinámico.
Probablemente, sin precedente de que se tenga referencia, la investigación llevada a cabo representa el primer caso de una planta de tratamiento de lodos activados en la República Mexicana, en el que se llevó a cabo un estudio extenso de modelación y calibración con el ASM1. Lo anterior constituye una contribución substancial en los esfuerzos llevados a cabo para introducir la práctica de modelación en las plantas del país.
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Xavier, Bruna Catarino. "Relações tectonicas no setor central da faixa Araçuaí: Análise estrutural por ASM e geocronologia U/Pb e Lu/Hf". Universidade de São Paulo, 2017. http://www.teses.usp.br/teses/disponiveis/44/44141/tde-22082017-094730/.
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A Faixa Araçuaí, localizada na porção setentrional da Província Mantiqueira, pode ser dividida em três domínios estruturais os quais estão envolvidos em um sistema de empurrões com vergência tanto oeste quanto para leste. A porção ocidental corresponde ao Domínio Milonítico constituido por gnaisses miloníticos de alta temperatura ~750ºC, o Domínio Central é caracterizado por intenso magmatismo tonalítico, granodiorítico e granítico de idade aproximada de 580 Ma e o setor oriental, denominado de Domínio Anatético, formado pelo Leucogranito Carlos Chagas (CC), um granito tipo S de idades compreendidas entre 572 ± 4 Ma a 597 ± 3 Ma. O Domínio Central, formado pelas Suítes Galiléia e Aimorés, são constituídas respectivamente pelos tonalitos São Vitor, e Galiléia e pelo Granito Caladão e o Charnockito Padre Paraíso. A Suíte Aimorés e a borda oeste do Leucogranito Carlos Chagas, constituem-se no foco desta dissertação, a qual teve por meta um estudo estrutural, baseado em Anisotropia de Suscetibilidade Magnética (ASM) e datações através dos métodos U/Pb em zircões e monazitas e Lu/Hf em zircões. Petrograficamente o Granito Caladão tem como característica uma textura porfirítica, com matriz de granulação grossa, composta por quartzo, feldspato, hornblenda e biotita, com cristais de feldspatos de 2 a 5 centímetros. O Charnockito Padre Paraíso é um hiperstênio granito, de cor esverdeada, de matriz de granulação grossa composta de quartzo, feldspato, hiperstênio, biotita e hornblenda, com cristais de feldspato de até 6 centímetros. O Leucogranito Carlos Chagas possui granulação media a grossa e apresenta em sua constituição, quartzo, feldspato, biotita sillimanita, cordierita e granada. Um granito tipo S. Os resultados da análise estrutural através da ASM apresentaram orientações variáveis da foliação magnética em setores distintos dos corpos magmáticos, compatível com a orientação espacial do plúton, indicando assim sua colocação, porém a orientações das lineações magnéticas sugerem uma direção predominantemente NNE-SSW, aventando um fluxo magmático nessa direção. Investigações sobre a mineralogia magnética através de curvas termomagnéticas evidenciaram ocorrências de óxidos de ferro, magnetita e hematita, tanto no Granito Caladão como no Charnockito Padre Paraíso. Os baixos valores de suscetibilidade magnética, da ordem de 10-4 a 10-5 SI sugerem que a ASM, para esses corpos ígneos, é controlada essencialmente pelos minerais paramagnéticos. Os elipsoides de ASM são dominantemente oblatos, caracterizando uma forte deformação por achatamento, apenas localmente foram identificados elipsoides prolato. As análises isotópicas forneceram idades de 500.7 ± 1.5 Ma a 512.1 ± 1.5 Ma (zircão) e 445.0 ± 9.5 Ma (monazita) para o Granito Caladão e de 498 ± 2.4 Ma a 502.7 ± 1.9 Ma (zircão) para o Charnockito Padre Paraíso. Idades obtidas como sendo mais antigas para o Granito Caladão e o Charnockito Padre Paraíso, respectivamente de 556.8 ± 3.7 Ma (zircão) e 576.0 ± 2.2 Ma (zircão) foram interpretadas como zircões herdados das rochas encaixantes quando do emplacement dos plutons. A idade de 570.1 ± 1.7 Ma para o CC na porção norte é compatível com as idades obtidas na literatura, entretanto na porção sul, as idades obtidas são da ordem de 510.8 ± 1.7 Ma e 520.5 ± 2.5 Ma para o CC, indicando pulsos magmáticos diacronicos. As determinações Lu/Hf revelaram valores de ?Hf negativos para todos os plutons estudados, mostrando que são provenientes de retrabalhamento crustal, de uma crosta arqueana e paleoproterozoica.The Araçuaí Orogen corresponds the northern part of the Mantiqueira Province, which can be divided into three different structural domains. These areas are involved in thrust systems towards the west and east. The western part corresponds to the Mylonites Domain, constituted by high temperature mylonitic gneisses, the Central Domain is characterized by a huge tonalitic, granodioritic and granitic magmatism dated around 580 Ma, and, the eastern area, described as Anatexis Domain where the Carlos Chagas Leucogranite (CC) is the predominant lithology. The Galiléia Suite constituting by the St. Vitor and Galiléia tonalites, Aimorés Suites, by the Caladão Granite and the Padre Paraíso Charnockite, all theses suites belong to the Central Domain. The Aimorés Suite and the western border of the Carlos Chagas Leucogranite are the focus of this Master thesis, which the goals are a structural study based on Anisotropy of Magnetic Susceptibility (AMS) and a geochronological analysis using U/Pb in zircon and monazite and Lu/Hf in zircon methodologies. The petrographic analysis shows the Caladão Granite as porphyritic granite, with a thick granulation matrix composed of quartz, feldspar, hornblende and biotite. The feldspar crystals can reach 2 to 5 centimeters in size. The Padre Paraíso Charnockite is hypersthene granite; greenish-colored matrix with a coarse granulation composed of quartz, feldspar, hypersthene, biotite and hornblende, the feldspar crystals size can be bigger than 5 centimeters. The Carlos Chagas Leucogranite has medium to coarse granulation that is constituted by quartz, feldspar, biotite, sillimanite, cordierite and garnet, the mineralogy typical of type S granite. Structural analysis using the AMS showed variable magnetic foliation orientations in distinct sectors of the magmatic bodies, compatible with the spatial trend of the pluton, your emplacement, but the orientations of the magnetic lines suggest a predominantly NNE-SSW direction, suggesting a magmatic flow in this direction. Investigations on magnetic mineralogy through thermomagnetic curves showed evidence of iron magnetite and hematite oxides in both the Caladão Granite and the Padre Paraíso Charnockite. The low values of magnetic susceptibility, on the order of 10-4 to 10-5 SI, suggest that paramagnetic minerals essentially control the ASM for these igneous bodies. The AMS ellipsoids are predominantly oblate, characterizing a strong flattening deformation; only locally prolate ellipsoids have been identified. Isotopic analyzes performed at Caladão Granite provided ages ranging from 500.7 ± 1.5 Ma to 512.1 ± 1.5 Ma (zircon) and 445.0 ± 9.5 Ma (monazite), and zircon ages from 498 ± 2.4 Ma to 502.7 ± 1.9 Ma obtained in the Padre Paraíso Charnockite. Older zircon ages determined in the Caladão Granite and Padre Paraíso Charnockite are, respectively, 556.8 ± 3.7 Ma and 576.0 ± 2.2Ma, whose ages were interpreted as inherited zircons that were captured from the host rocks during the plutons emplacement. In the northern sector of the studied area, the CC age of 570.1 ± 1.7 Ma is compatible with the ages that were obtained in the literature, ranging from 572 ± 4 Ma to 597 ± 3 Ma, however in the south of the area some surprisingly younger ages (510.8 ± 1.7 Ma and 520.5 ± 2.5 Ma) in the CC, suggesting diachronic magmatic pulses. The Lu/Hf determinations revealed negative ?Hf values for all studied plutons, showing that they are derived from crustal reworking, from an Archaean and Paleoproterozoic crust. The most Hf model age are 2,0 Ga, however there are some Archean ages ranging from 3.0 to 3.8 Ga. The presence of highly negative values of -20 and -30 for the Caladão Granite are interpreted as largely crustal-derived melts.
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Hauduc, Hélène. "Modèles biocinétiques de boues activées de type ASM : Analyse théorique et fonctionnelle, vers un jeu de paramètres par défaut". Phd thesis, AgroParisTech, 2010. http://pastel.archives-ouvertes.fr/pastel-00564735.
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La modélisation du fonctionnement des stations d'épuration est un outil largement utilisé notamment pour l'optimisation et la réhabilitation des ouvrages existants et le dimensionnement de nouvelles installations. S'assurer d'une bonne qualité des modèles est donc primordial. Or, d'après les résultats d'une enquête internationale effectuée auprès de 96 utilisateurs potentiels de modèles, deux étapes dans l'utilisation des modèles sont considérées comme particulièrement délicates: le choix du modèle à utiliser parmi les modèles disponibles et l'étape de calage de ces modèles. Le travail présenté visait à fournir des éléments pour lever des obstacles à une utilisation plus généralisée des modèles biocinétiques à boues activées. Il a porté sur sept des modèles publiés : (1) ASM1, (2) ASM2d, (3) ASM3, (4) ASM3+BioP, (5) ASM2d+TUD, (6) Barker & Dold et (7) UCTPHO+. Dans un premier temps, une analyse des connaissances pratiques des modèles a été effectuée afin d'améliorer le transfert des connaissances en modélisation. Une base de données de jeux de paramètres a été créée à partir d'études publiées et d'un questionnaire adressé aux utilisateurs de modèles. Cette base de données a notamment permis d'établir des fourchettes de valeurs utilisées pour l'ASM1 et l'ASM2d. Puis, une analyse connaissances théoriques ayant pour but d'aider les utilisateurs à mieux comprendre les sept modèles et à choisir le modèle adapté à leur projet a été réalisée. Les modèles étudiés ont d'abord été vérifiés et les erreurs de frappe et incohérences ont été corrigées. Les concepts de modélisation ont été comparés entre eux grâce à une nouvelle représentation graphique, et confrontés aux connaissances sur le fonctionnement biologique des boues activées afin de mettre en évidence les limites théoriques des modèles. En dernier lieu, une méthodologie a été développée pour l'obtention de jeux de paramètres par défaut qui pourraient être utilisés comme valeurs initiales lors du calage des modèles. Pour cela, une procédure de calage multi-jeux de données a été élaborée. Cela nécessite au préalable le développement d'une procédure de calage automatisée et l'utilisation d'un critère de qualité permettant de définir l'arrêt de la procédure de calage. Une analyse est effectuée sur les critères de qualité utilisés en sciences de l'environnement.
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Sharma, Deepa [Verfasser] y Erich [Akademischer Betreuer] Gulbins. "Regulation and function of acid sphingomyelinase (ASM)/ceramide pathway in irradiation-induced cell death / Deepa Sharma. Betreuer: Erich Gulbins". Duisburg, 2015. http://d-nb.info/1079182489/34.
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Aguiar, Kardec Alecxandro Abrantes. "Efeitos agudos do alongamento de m?sculos respirat?rios em asm?ticos: estudo cross-over, randomizado e duplo-cego". Universidade Federal do Rio Grande do Norte, 2015. http://repositorio.ufrn.br/handle/123456789/20339.
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Introdu??o: A asma ? uma doen?a inflamat?ria cujas crises podem se reverter espontaneamente ou com tratamento farmacol?gico. A exposi??o prolongada aos seus efeitos pode comprometer a a??o dos m?sculos respirat?rios. Assim, embora o alongamento destes m?sculos seja visto como t?cnica de potencial benef?cio no tratamento e controle das pneumopatias cr?nicas, poucos estudos avaliaram asm?ticos. Objetivos: Avaliar os efeitos agudos de um protocolo de alongamento de m?sculos respirat?rios sobre os volumes pulmonares, frequ?ncia respirat?ria, volume minuto, ?ndice de velocidade de encurtamento de m?sculos respirat?rios e toler?ncia ao exerc?cio em asm?ticos com doen?a controlada. Materiais e m?todos: estudo crossover, randomizado, duplo-cego no qual a amostra foi composta por asm?ticas alocadas em dois grupos: grupo alongamento (GA) e grupo placebo (GP). O GA recebeu um protocolo de alongamento, enquanto o GP, manobra placebo. As vari?veis foram analisadas durante o exerc?cio utilizando pletismografia optoeletr?nica. An?lise estat?stica: as m?dias dos volumes pulmonares, frequ?ncia respirat?ria, volume minuto e ?ndice de velocidade de encurtamento dos m?sculos respirat?rios entre os grupos foram comparadas pela Two-way ANOVA com post hoc de Bonferroni. O tempo de toler?ncia ao exerc?cio e a percep??o de esfor?o foram comparados pelo teste t pareado. Foi considerado como valor de signific?ncia estat?stica p < 0,05. Resultados: Foram avaliadas 11 asm?ticas com m?dia de idade de 35,5 ? 7,8 anos, IMC de 24,4 ? 2,4 Kg/m2 , CVF e VEF1 igual a 95,8 ? 10,3 e 85,3 ? 11,5 % do valor predito, respectivamente. N?o houve diferen?as nos volumes pulmonares entre os grupos (alongamento versus placebo) durante o exerc?cio, ocorrendo diferen?as na an?lise intragrupo entre suas etapas (p < 0,01). A frequ?ncia respirat?ria e volume minuto foram similares nos grupos (p = 0,68 e 0,52). O ?ndice de velocidade de encurtamento dos m?sculos inspirat?rios da caixa tor?cica pulmonar foi menor no grupo alongamento, particularmente nos momentos de pedalada com carga (GP = 0,571 ? 0,222; GA = 0,533 ? 0,204 L/s) e recupera??o (GP = 0,591 ? 0,222; GA = 0,531 ? 0,244 L/s), por?m n?o existiu diferen?a com signific?ncia estat?stica (p = 0,27). O tempo de toler?ncia ao exerc?cio foi similar entre os grupos (GP = 245 ? 109 seg versus GA = 218 ? 55,5 seg, p = 0,31). A varia??o do escore de Borg para percep??o de fadiga se mostrou menor no GA (6,86 ? 0,55 versus 7,59 ? 0,73, p = 0,02). Conclus?o: O alongamento de m?sculos respirat?rios, considerando seus efeitos agudos, n?o modifica os volumes pulmonares, frequ?ncia respirat?ria, volume minuto e ?ndice de velocidade de encurtamento de m?sculos respirat?rios de asm?ticos com doen?a controlada. Os resultados sugerem que o alongamento n?o influenciou a toler?ncia ao exerc?cio com carga constante, embora tenha sido relatada menor sensa??o de fadiga nos indiv?duos que se submeteram ? t?cnica.
Introduction: Asthma is an inflammatory disease which attacks may reverse spontaneously or with pharmacological treatment. Prolonged exposure to its effects may impair action of the respiratory muscles. Thus, while the stretching these muscles is seen as a potential technique benefit in the treatment and control of chronic lung disease, few studies evaluated asthmatics. Objectives: Assess the acute effects of a stretching protocol of respiratory muscles on lung volumes, respiratory rate, minute volume, shortening velocity index of respiratory muscles and exercise tolerance in asthmatics with controlled disease. Materials and methods: crossover, randomized, double-blind study in which the sample was composed of asthmatic allocated into two groups: stretching group (GA) and placebo group (PG). The GA received a stretching protocol, while the GP, placebo maneuver. The variables were analyzed during the exercise using plethysmography optoelectronics. Statistical analysis: the mean of lung volumes, respiratory rate, minute volume and velocity of shortening index of the respiratory muscles between groups were compared by two-way ANOVA with Bonferroni post hoc. The exercise tolerance time and perceived exertion were compared between groups by paired t test. Was considered significant statistical value p <0.05. Preliminary results: We assessed 11 asthmatic with a mean age of 35.5 ? 7.8 years, BMI 24.4 ? 2.4 kg / m2, FVC and FEV1 equal to 95.8 ? 10.3 and 85.3 ? 11, 5% of the predicted value, respectively. There were no differences in lung volumes between groups (stretching versus placebo) during exercise, occurring differences in intra-group analysis of its stages (p <0.01). The respiration rate, and minute volume were similar in both groups (p = 0.68 and 0.52). The shortening velocity index of the inspiratory muscles pulmonary rib cage was lower in the stretching group, particularly in moments of pedaling load (GP = 0.571 ? 0.222, 0.533 ? 0.204 GA = L / s) and recovery (GP = 0.591 ? 0.222, GA = 0.531 ? 0.244 L / s), however there was no statistically significant difference (p = 0.27). The time of exercise tolerance was similar between groups (GP = 245 ? 109 seconds versus 218 ? GA = 55.5 sec, p = 0.31). The change in Borg score for perception of fatigue was lower in GA (6.86 ? 0.55 versus 7.59 ? 0.73, p = 0.02). Conclusion: The stretching of respiratory muscles, considering its acute effects, does not modify the pulmonary volumes, respiratory rate, minute volume and the shortening velocity index of respiratory muscles of asthma patients with controlled disease. The results suggest that the technique did not influence exercise tolerance with constant load, although it was observed a lower sense of fatigue in individuals who underwent technique.
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Furtado, Priscilla Rique. "Rela??o entre qualidade de vida, capacidade de exerc?cio e qualidade de sono de crian?as asm?ticas". Universidade Federal do Rio Grande do Norte, 2015. http://repositorio.ufrn.br/handle/123456789/20340.
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Introdu??o: A determina??o da qualidade de vida (QV) de crian?as asm?ticas ? importante, pois, a asma grave ou com sintomas mal controlados, pode impedir a participa??o em atividades esportivas, prejudica o sono e o rendimento escolar, o que contribui para uma qualidade de vida ruim9 . Objetivos: Avaliar a rela??o entre qualidade de vida, capacidade de exerc?cio, e qualidade de sono de crian?as asm?ticas. Materiais e m?todos: Trata-se de um estudo observacional do tipo anal?tico transversal. A dispneia e a fadiga de membros inferiores foi alvaliada atrav?s da Escala 10-point Borg category-ratio (CR10); a espirometria, utilizando um espir?metro port?til digital KOKO? (Longmont, Estados Unidos da Am?rica); a qualidade de sono e presen?a de dist?rbios do sono, utilizando a Escala de dist?rbio de sono para crian?as (EDSC); a capacidade funcional, pelo teste do degrau de 6 minutos (TD6); e a qualidade de vida pelo Question?rio sobre a Qualidade de Vida na Asma Pedi?trica (QQVAP). O aceler?metro Actilife GT3X foi usado para classifica??o do n?vel de atividade f?sica. Foi utilizado o SPSS 17, n?vel de signific?ncia de 5%, e o teste de Kolmogorov-Smirnov para normalidade de dados. A estat?stica descritiva se deu atrav?s de m?dias, desvio padr?o e porcentagem. Os testes ?t? e ANOVA oneway foram usados para an?lises comparativas da qualidade de vida. O coeficiente de correla??o de Pearson foi utilizado entre as vari?veis quantitativas e os escores do QQVAP. Foram realizadas an?lises de regress?o linear m?ltipla (m?todo backward) entre as vari?veis que se correlacionaram. Resultados: Participaram 45 crian?as asm?ticas de ambos os sexos (60% - masculino), de faixa et?ria entre 7-12 anos. Dentre elas, 51,1% tinham asma de intermitente ? leve, e 48,9% tinham asma moderada ? grave. Os dist?rbios observados foram: Dist?rbio respirat?rio de sono (n=20), Hiperhidrose do sono (n=12), e Dist?rbio de in?cio e manuten??o do sono (n=2). A amostra foi composta por 71,1% de crian?as sedent?rias ou com n?vel de atividade f?sica leve. A m?dia de TD6-T foi 175,9?32,9. As m?dias do QQVAP para o escore Total, e dom?nios: sintomas (S), limita??o de atividades (LA) e Fun??o emocional (FE), foram respectivamente, 5,5?1,2; 5,6?1,3; 4,9?1,4; 5,7?1,3. A gravidade da asma, a qualidade de sono, e ? dispneia sentida ap?s o TD6, explicaram 31% da varia??o do escore total do QQVAP, e 35,6% do dom?nio de sintomas. A dispneia ap?s o 60 minuto de TD6 explicou a 7,2% para o dom?nio LA, e a gravidade em conjunto com o sono, explicaram 16,2% para o escore FE. Conclus?o: Os achados do presente estudo sugerem que em crian?as asm?ticas, a qualidade de vida pode estar relacionada ? gravidade da asma, a qualidade de sono, e ? dispneia sentida ap?s exerc?cios f?sicos.
Introduction: The determination of the quality of life (QoL) of asthmatic children is important because, severe or poorly controlled asthma symptoms, may prevent participation in sports activities, impairs sleep and school performance, which contributes to worse quality of life. Objectives: To evaluate the relationship between quality of life, exercise capacity, and quality of asthmatic children sleep. Objectives: To avaluate the relationship between quality of life, exercise capacity and capacity of sleep of asthmatic children. Methods: This study is an observational cross sectional. Dyspnea and fatigue of the lower limbs were assessed by the 10-point Borg scale category-ratio (CR 10); spirometry, using a digital portable spirometer KOKO? (Longmont, United States of America); quality of sleep and presence of sleep disorders, using The Sleep Disturbance Scale for Children (SDSC); for functional capacity, the 6MST was used; and for quality of life, the Pediatric Asthma Quality of Life Questionnaire (PAQLQ). The accelerometer Actilife GT3X was used for physical activity level classification. We used the SPSS 17, assigning the significance level of 5%, and Kolmogorov-Smirnov test for normality of data. Descriptive statistics are given as mean, standard deviation and percentage. The "t" test and oneway ANOVA were used for comparative analysis of the quality of life. The Pearson correlation coefficient was used between quantitative variables and PAQLQ scores. Multiple linear regression analysis (backward method) between the variables that correlated were made. Results: were 45 asthmatic children of both sexes (60% - male), at age 7-12 years. Among them, 51.1% had asthma intermittently to light, and 48.9% had moderate to severe asthma. The following sleep disorders were observed: sleep-disordered breathing (n = 20), sleep hyperhydrosis (n = 12), and disorders of initiating and maintaining sleep (n = 2). The sample consisted of 71.1% of sedentary children or with low physical activity level. The 6MST-T average was 175.9 ? 32.9. QQVAP mean for the Total score and domains: symptoms, activity limitation (AL) and emocional function (EF) were, respectively, 5.5?1.2; 5.6?1.3; 4.9?1.4; 5.7?1.3. Asthma severity, sleep quality, and dyspnea felt after 6MST, explained 31% of the change in total score QQVAP, and 35.6% of domain symptoms. Dyspnea after 6 minutes of TD6, 7.2% for the AL field and gravity level in combination with sleep, to 16.2% explained EF score. Conclusion: The findings of this study suggest that in asthmatic children, the quality of life may be related to asthma severity, sleep quality, and dyspnea felt after exercise.
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Hauduc, Hélène. "Modèles biocinétiques de boues activées de type ASM : analyse théorique et fonctionnelle, vers un jeu de paramètres par défaut". Doctoral thesis, Université Laval, 2011. http://hdl.handle.net/20.500.11794/22384.
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La modélisation du fonctionnement des stations d'épuration est un outil largement utilisé notamment pour l'optimisation et la réhabilitation des ouvrages existants et le dimensionnement de nouvelles installations, par les ingénieurs et par les chercheurs. S'assurer d'une bonne qualité des modèles est donc primordial. Or, d'après les résultats d'une enquête internationale effectuée auprès de 96 utilisateurs potentiels de modèles, deux étapes dans l’utilisation des modèles sont considérées comme particulièrement délicates: le choix du modèle à utiliser parmi les modèles disponibles et l'étape de calage de ces modèles. Le travail présenté visait à fournir des éléments pour lever des obstacles à une utilisation plus généralisée des modèles biocinétiques à boues activées. Il a porté sur sept des modèles publiés : (1) ASM1, (2) ASM2d, (3) ASM3, (4) ASM3+BioP, (5) ASM2d+TUD, (6) Barker & Dold et (7) UCTPHO+. Dans un premier temps, une analyse des connaissances pratiques des modèles a été effectuée afin d'améliorer le transfert des connaissances en modélisation. Une base de données de jeux de paramètres a été créée à partir d'études publiées et d'un questionnaire adressé aux utilisateurs de modèles. Cette base de données a notamment permis d'établir des fourchettes de valeurs utilisées pour l'ASM1 et l'ASM2d. Puis, une analyse des connaissances théoriques ayant pour but d'aider les utilisateurs à mieux comprendre les sept modèles et à choisir le modèle adapté à leur projet a été réalisée. Les modèles étudiés ont d'abord été vérifiés et les erreurs de frappe et incohérences ont été corrigées. Les concepts de modélisation ont été comparés entre eux grâce à une nouvelle représentation graphique, et confrontés aux connaissances sur le fonctionnement biologique des boues activées afin de mettre en évidence les limites théoriques des modèles. En dernier lieu, une méthodologie a été développée pour l'obtention de jeux de paramètres par défaut qui pourraient être utilisés comme valeurs initiales lors du calage des modèles. Pour cela, une procédure de calage multi-jeux de données a été élaborée. Cela nécessite au préalable le développement d'une procédure de calage automatisée et l'utilisation d'un critère de qualité permettant de définir l'arrêt de la procédure de calage. Une analyse est effectuée sur les critères de qualité utilisés en sciences de l'environnement.Mathematical modelling of activated sludge systems has become a widely accepted tool and is used in particular for optimization and upgrading of existing plants and for new facilities design, either by engineering and consulting companies, or university and research centers. Ensuring the adequate quality of modelling results is therefore essential. However, an international survey conducted among 96 potential users of activated sludge models (ASM) pointing to two main obstacles to the use of modelling: the selection of the model to use among the available models and the model calibration. The objective of this work was to provide elements to overcome these obstacles and to promote the wider use of biokinetic models for activated sludge systems. It focused on seven published models: (1) ASM1, (2) ASM2d, (3) ASM3, (4) ASM3+BioP, (5) ASM2d+TUD, (6) Barker & Dold and (7) UCTPHO+. First, an analysis of practical knowledge on the models was performed to improve the transfer of modelling knowledge. A database of practical modelling applications from published case studies and from the answers of a questionnaire sent to model users was created. This database enables to establish ranges of parameter values commonly used for the ASM1 and ASM2d. Then the theoretical knowledge on ASMs was analysed to help users to better understand the seven studied models and to select the model most appropriate to their project. The studied models were first verified and typing errors and inconsistencies have been corrected. The modelling concepts were compared to each other through a new graphical representation, and confronted with knowledge about the biology of activated sludge, in order to highlight the theoretical limits of each model. Finally, a methodology has been developed to obtain default parameter values that could be used as initial values for model calibration. To this end, an automated calibration procedure that allows calibration on multiple data sets was proposed. Then, the quality criteria used in environmental sciences have been synthesised. These criteria are required to determine the best set of parameters based on the goodness-of-fit of the model and to compare results from different models.
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Sautter, Cláudia Kaehler. "Indução pós-colheita da síntese de resveratrol e de resistência de frutos a podridões". Universidade Federal de Santa Maria, 2008. http://repositorio.ufsm.br/handle/1/3162.
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Coordenação de Aperfeiçoamento de Pessoal de Nível SuperiorThe objectives of this work were divided in two experiments phases. In the first phase, it was studied the presence of trans-resveratrol in temperate climate fruits and the variation of their concentration in these fruits during storage period, as well the amount of total phenols and total anthocyanins. It was evaluated total phenols, total anthocyanins and trans-resveratrol, before and after cold storage and under controlled atmosphere; and after five days shelf-life at 20°C in Bruno kiwifruit; Araza and Yvahe strawberries; Black mulberry; Galaxi , Gala and Fuji apples; persimmon Fuyu ; Bleugem blueberry, Isabel , Merlot and Niagara Pink grapes. It was detected trans-resveratrol in natura in flesh Bruno kiwifruit; Araza and Yvahe strawberries; Black mulberry. In other fruits, it was detected transresveratrol in natura in the skin. The cold storage stimulated trans-resveratrol synthesis in Bleugem blueberry, and Isabel and Merlot grapes. In the second phase, it was evaluated the induction of trans-resveratrol synthesis and its possible action as phytoalexin in Gala and Fuji apples stored in controlled atmosphere were evaluated. Experiments were with the application of abiotic elicitors: ultraviolet irradiation, phosphite and acibenzolar-S-methyl, applied before controlled atmosphere storage, and intermittent ozone applied during storage of to Gala and Fuji apples. Rot was controlled in another experiment with the same elicitors. In fruit bark it was analyzed trans-resveratrol; total phenols and total anthocyanins, as well as the diameter of injury after inoculation of Penicillium sp. The abiotic elicitors were induced in 'Fuji' apples trans-resveratrol synthesis in the following sequence: Acibenzolar-Smethyl > phosphite ³ UV-C irradiation ³ ozone, but it wasn t effective on 'Gala' apple. There was no correlation between the syntheses of trans-resveratrol and rotting control, with exception of phosphite was control of rot in 'Gala'.
Os objetivos deste trabalho foram alcançados em duas etapas. Na primeira etapa, o objetivo foi avaliar a presença de trans-resveratrol em frutos de clima temperado e a sua variação de concentração nesses frutos durante o período de armazenamento, assim como a evolução dos polifenóis totais e antocianinas totais. Avaliou-se o conteúdo de polifenóis totais, antocianinas totais e trans-resveratrol antes e após o armazenamento refrigerado e em atmosfera controlada, e após cinco dias de exposição a 20°C em kiwi Bruno , morangos Araza e Yvahe , amora (Morus nigra), maçãs Galaxi , Gala e Fuji , caqui Fuyu , mirtilo Bleugem , uvas Isabel , Merlot e Niágara Rosada . Detectou-se o trans-resveratrol in natura em polpa de kiwi Bruno , morangos Araza e Yvahe e amora Preta . Nos demais fruto, detectou-se in natura trans-resveratrol na casca. O armazenamento refrigerado estimulou a síntese de trans-resveratrol em mirtilo Bleugem , uvas Isabel e Merlot . Na segunda etapa, o objetivo foi avaliar a indução da síntese de trans-resveratrol e sua possível ação como fitoalexina em maçãs Gala e Fuji , armazenadas em atmosfera controlada. Realizaram-se experimentos com aplicação de elicitores abióticos: irradiação ultravioleta, fosfito e acibenzolar-S-metil, aplicados antes do armazenamento em atmosfera controlada, e ozônio aplicado de forma intermitente durante o armazenamento de maçãs Gala e Fuji . Realizou-se o controle de podridão em outro experimento com os mesmos elicitores. Na casca dos frutos analisaram-se trans-resveratrol, polifenóis totais e antocianinas totais, e o diâmetro de lesão após inoculação por Penicillium sp. Os elicitores abióticos induziram a síntese de trans-resveratrol em maçã Fuji na seguinte ordem: Acibenzolar-S-metil > Fosfito ³ irradiação UV-C ³ ozônio, mas não apresentaram efeito em maçãs Gala , durante o armazenamento em atmosfera controlada. Os elicitores abióticos não apresentaram efeito no controle de podridão, com exceção do fosfito que controlaram a podridão em maçã Gala . Não houve correlação entre a síntese de trans-resveratrol e o controle de podridão.
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Talbot, Jean-Yves. "Apport des études ASM et gravimétriques des plutons cévenols à la caractérisation structurale de l'évolution tardi-hercynienne du Massif Central". Phd thesis, Université d'Orléans, 2003. http://tel.archives-ouvertes.fr/tel-00005395.
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Une étude associant des mesures structurales par ASM, un levé gravimétrique et de nouvelles datations 40Ar/39Ar a été menée sur trois massifs granitiques du Sud-Est du Massif Central : les plutons de la Margeride, du Mont-Lozère – Borne et de l'Aigoual – Saint-Guiral – Liron. Les trois massifs, sub-contemporains, se sont mis en place autour de 305-310 Ma. Pour les trois plutons, les microstructures sont majoritairement de type magmatique ou acquises lors d'une déformation à l'état solide à haute température. Les linéations magnétiques, essentiellement NW-SE à E-W subhorizontales, reflètent la déformation régionale extensive tardi-hercynienne post-collisionnelle. Localement, comme dans les dykes microgranitiques au Nord de l'Aigoual, les fabriques ASM ont, au contraire, enregistré l'écoulement du magma. A partir de la combinaison des données gravimétriques, existantes ou nouvellement acquises, et ASM, des modèles de mise en place sont proposés pour chacun des trois plutons.
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Weich, Wolfgang Frederik [Verfasser] y Klaus [Akademischer Betreuer] Fassbender. "Bedeutung der sauren Sphingomyelinase (ASM) in der Funktion der Makrophagen : Rolle der Lipid Rafts / Wolfgang Frederik Weich. Betreuer: Klaus Fassbender". Saarbrücken : Saarländische Universitäts- und Landesbibliothek, 2014. http://d-nb.info/105398328X/34.
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Lins, Thalita Medeiros Fernandes de Macedo. "Efeitos do m?todo Buteyko nos dist?rbios do sono de crian?as asm?ticas respiradoras orais: estudo controlado randomizado". PROGRAMA DE P?S-GRADUA??O EM FISIOTERAPIA, 2016. https://repositorio.ufrn.br/jspui/handle/123456789/22537.
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Introdu??o: A asma ? uma das doen?as cr?nicas mais comuns em crian?as, com importante morbidade e mortalidade nos indiv?duos acometidos. A respira??o oral ? um dist?rbio respirat?rio tamb?m com elevada preval?ncia na popula??o infantil. Terap?utica n?o farmacol?gica tem sido amplamente utilizada na busca de terapias alternativas no tratamento dessa patologia, dentre elas, encontra-se o m?todo Buteyko. Objetivo: Avaliar os efeitos do m?todo Buteyko como terapia adjunta no tratamento de crian?as asm?ticas respiradoras orais. Materiais e m?todos: Trata-se de um estudo controlado, randomizado e simples-cego onde 35 crian?as com asma do tipo leve ou moderada, na faixa et?ria entre 7 e 12 anos e diagn?stico fonoaudiol?gico de respirador oral foram divididas em 2 grupos (Buteyko e controle). Todas as crian?as realizaram avalia??o respirat?ria em dois momentos: inicial e final. Foram realizadas avalia??es antropom?tricas, dos dist?rbios de sono por meio da Escala de Dist?rbios de Sono em Crian?as, da fun??o pulmonar (ventilometria e espirometria) e do relato de sintomas (hospitaliza??o e faltas na escola). As crian?as do grupo Buteyko (20 crian?as) realizaram treinamento presencial em grupo do m?todo Buteyko duas vezes por semana durante 3 semanas e monitoramento semanal do controle de sintomas foi realizado nos dias presenciais. Foi fornecido um v?deo com orienta??es para a realiza??o do m?todo Buteyko diariamente no domic?lio por 3 semanas. As crian?as do grupo controle (15 crian?as) receberam aula educativa e foram contatadas semanalmente para relato do controle dos sintomas. Os dados foram analisados por meio do software SPSS 20.0, com n?vel de signific?ncia de 5%. A normalidade dos dados foi verificada pelo teste de Shapiro-Wilk, o de Levene para homogeneidade das vari?ncias e ANOVA two way para verificar diferen?as intra e intergrupos. O test t de student n?o pareado foi realizado para comparar a vari?vel altura e o de Mann-whitney para compara??o das vari?veis peso, idade, percentil e faltas na escola entre os grupos. O teste Exato de Fisher foi realizado para comparar a distribui??o de g?neros e a classifica??o da asma e o qui-quadrado para comparar o percentual de dist?rbios do sono apresentado pelas crian?as inicialmente. Resultados: Ap?s o treinamento, o grupo Buteyko melhorou de forma significativa os escores das dimens?es dist?rbios respirat?rios do sono, dist?rbios do despertar, dist?rbios de transi??o sono vig?lia (DTSV), escore total dos dist?rbios do sono, capacidade vital for?ada (CVF), pico de fluxo expirat?rio e fluxo expirat?rio for?ado entre 25% e 75% da CVF (FEF25-75%). Comparativamente ao grupo controle, na avalia??o final, o grupo Buteyko melhorou tamb?m os DTSV, escore total do sono, FEF25-75%, a rela??o entre o volume expirat?rio for?ado no primeiro segundo com a CVF e o n?mero de faltas na escola. Conclus?o: O treinamento com m?todo Buteyko proporcionou melhora dos dist?rbios do sono, da fun??o pulmonar e redu??o do n?mero de faltas na escola de crian?as asm?ticas respiradoras orais.
Introduction: Asthma is one of the most common chronic diseases in children, with important morbidity and mortality in affected individuals. Oral breathing is also a respiratory disorder with a high prevalence in the child population. Non-pharmacological therapy has been widely used in the search for alternative therapies in the treatment of this pathology, among them, the Buteyko method is found. Objective: To evaluate the effects of the Buteyko method as an adjunct therapy in the treatment of asthmatic mouth breathing children. Materials and methods: This is a randomized, single-blind, controlled study in which 35 children with mild or moderate asthma between 7 and 12 years of age and speech-language pathologist diagnosis were divided into two groups (Buteyko and control). All the children underwent respiratory evaluation in two moments: initial and final. Anthropometric assessments, sleep disturbances through the Sleep Disorders Scale in Children, pulmonary function (ventilometry and spirometry) and symptom reporting (hospitalization and absences at school) were performed. The children of the Buteyko group (20 children) conducted face-to-face group training of the Buteyko method twice a week for 3 weeks and weekly monitoring of symptom control was performed. A video was provided with guidelines for performing the Buteyko method daily at home for 3 weeks. The children in the control group (15 children) received an educational class and were contacted weekly to report their symptoms. Data were analyzed using SPSS 20.0 software, with a significance level of 5%. The normality of the data was verified by the Shapiro-Wilk test, the Levene test for homogeneity of variances and two-way ANOVA to verify intra and intergroup differences. The unpaired Student's t-test was performed to compare the height and Mann-Whitney variables for comparison of variables weight, age, percentile and school absences between groups. Fisher's exact test was performed to compare the distribution of genders and the classification of asthma and chi-square to compare the percentage of sleep disorders presented by children initially. Results: After training, the Buteyko group significantly improved scores on sleep disturbances, disorders of arousal, sleep-wake transition disorders (SWTD), total sleep disturbance scores, forced vital capacity (FVC), peak of expiratory flow and forced expiratory flow between 25% and 75% of FVC (FEF25-75%). Compared to the control group, in the final evaluation, the Buteyko group also improved SWTD, total sleep score, FEF25-75%, the relation between forced expiratory volume in the first second with FVC and number of school absences. Conclusion: The training with Buteyko method provided improvement of sleep disorders, lung function and reduction in the number of absences in the school of asthmatic mouth breathing children.
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Vigneron, Pierre. "Mesures vectorielles expérimentales des instruments ASM de la mission SWARM, : du commissioning à la production de modèles de champs géomagnétiques". Thesis, Université de Paris (2019-....), 2019. http://www.theses.fr/2019UNIP7162.
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Les trois satellites de la mission SWARM de l’agence spatiale européenne (ESA), lancés le 22 Novembre 2013, ont pour objectif central de mesurer le champ magnétique terrestre. Sur chaque satellite, la charge utile principale (dédiée à la magnétométrie) comporte un magnétomètre relatif (VFM) solidaire de caméras stellaires (STR) placé sur un bras, à l’extrémité duquel se trouve également un magnétomètre absolu (ASM). Le rôle nominal de l’ASM est de fournir une mesure scalaire absolue du champ, utilisée à la fois pour les besoins scientifiques de la mission et pour permettre la calibration des données fournies par le VFM, dont l’attitude est restituée grâce aux données fournies par les STR. En utilisant un concept innovant mis au point par le CEA-Léti, l’ASM a cependant aussi la capacité de fournir seul et simultanément une mesure vectorielle auto- calibrée du champ magnétique. La fourniture de cet instrument à l’ESA par le CNES a permis de tester ce mode pour la première fois de manière opérationnelle dans l’espace. En tirant parti de la disponibilité simultanée des données vectorielles nominales de la mission et des données expérimentales fournies par les ASM, il a été possible de tester avec succès la qualité et le potentiel scientifique de ces dernières. Cette thèse rapporte les travaux menés dans ce sens, depuis les travaux initiaux (de type « commissioning ») ayant permis de valider dans l’espace le principe même de cette mesure vectorielle expérimentale, jusqu’à la démonstration progressive de l’intérêt scientifique de telles données, pour notamment la construction de modèles géomagnétiques globaux de très bonne qualité. Ces travaux ont aussi été l’occasion d’identifier les conditions optimales de fonctionnement vectoriel de l’instrument ASM (et les perturbations pouvant affecter les données), d’améliorer la stratégie d’auto-calibration des données, et même de contribuer à la caractérisation et à la remédiation de problèmes affectant l’ensemble de la mission (y compris les données nominales). De nombreuses leçons ont été tirées de ces travaux et mises à profit par le CEA-Léti, qui travaille aujourd’hui à la conception d’une version miniaturisée de l’instrument ASM, désormais proposé comme charge utile principale sur un nouveau projet de constellation de nanosatellites, le projet NanoMagSat (déposé conjointement à l’appel d’offre « Scout » de l’ESA, par l’IPGP, le CEA-Léti, la Société Open Cosmos, et l’Université d’Oslo) pour compléter et prendre la suite de la mission SwarmThe three satellites of the European Space Agency (ESA) SWARM mission were launched on 22 November 2013, with the central goal of investigating the Earth’s magnetic field. The main payload on each satellite consists of a relative vector magnetometer (VFM) close to a set of star cameras (STR) placed on a boom, at the very tip of which sits an absolute magnetometer (ASM). The nominal role of this ASM is to provide absolute scalar measurements of the field, for both scientific investigations and calibration of the data provided by the VFM, the attitude of which is reconstructed using the information provided by the STR. However, and thanks to an innovative design by CEA-Léti, the ASM instrument has the ability to also simultaneously provide self-calibrated vector measurements of the magnetic field. This instrument having been funded by CNES as a customer furnished instrument to ESA, the possibility was provided to test its vector capacity for the first time in operational mode in space. By taking advantage of the simultaneous availability of nominal vector data and experimental vector data provided by the ASM instruments, the quality and usefulness of the latter could successfully be tested. The present manuscript provides an account of all the work carried out along those lines, reporting on the « commissioning » type of activities that confirmed the validity of the operating principle of this experimental vector mode, as well as on the progressive demonstration of the scientific value of the data provided, most notably for the purpose of building high quality global geomagnetic field models. This work also provided the opportunity to identify the conditions best suited for operating the vector mode of the ASM instrument (as well as the perturbations potentially affecting the data), to improve the self- calibration strategy of the vector data, and even to contribute to the characterisation and remediation of problems affecting the mission as a whole (including nominal data). Many lessons could be drawn for this work, which CEA-Léti could take advantage of to design an improved miniaturized version of the ASM instrument, now proposed as the main payload for a new NanoMagSat nanosatellite constellation project, (jointly proposed by IPGP, CEA-Léti, the Open Cosmos company, and the University of Oslo in response to the recent ESA « Scout » ITT) for the purpose of complementing and next take over the Swarm mission
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Modesto, Francisco. "Development of a Java Bytecode Front-End". Thesis, Växjö University, School of Mathematics and Systems Engineering, 2009. http://urn.kb.se/resolve?urn=urn:nbn:se:vxu:diva-6210.
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The VizzAnalyzer is a powerful software analysis tool. It is able to extract information from various software representations like source code but also other specifications like UML. The extracted information is input to static analysis of these software projects. One programming language the VizzAnalyzer can extract information from is Java source code.
Analyzing the source code is sufficient for most of the analysis. But, sometimes it is necessary to analyze compiled classes either because the program is only available in byte-code, or the scope of analysis includes libraries that exist usually in binary form. Thus, being able to extract information from Java byte-code is paramount for the extension of some analyses, e.g., studying the dependecy structure of a project and the libraries it uses.
Currently, the VizzAnalyzer does not feature information extraction from Java byte-code. To allow, e.g., the analysis of the project dependency structure, we extend the VizzAnalyzer tool with a bytecode front-end that will allow the extraction of information from Java bytecode.
This thesis describes the design and implementation of the bytecode front-end. After we implemented and integrated the new front-end with the VizzAnalyzer, we are now able to perform new analyses that work on data extracted from both, source- and bytecode.
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Montes, de Oca Fuentes Eden Victor. "Evaluación de la variabilidad diurna de las fracciones de DQO del ASM1 en aguas residuales municipales de Toluca". Tesis de Licenciatura, Universidad Autónoma del Estado de México, 2006. http://hdl.handle.net/20.500.11799/94529.
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En las últimas tres décadas se han realizado numerosos estudios acerca del control y manejo de los procesos biológicos. A este respecto, los primeros resultados significativos aparecieron con la formalización matemática de los fenómenos biológicos, particularmente en lo referente a la formulación de la expresión de tasas de crecimiento y decaimiento específico, de tales bioprocesos (Harmand, 2004).
Actualmente con el desarrollo en el conocimiento del cálculo y los algoritmos disponibles en paquetes de computo se ha permitido la aplicación de la simulación numérica para la optimización en la generación y control de sistemas, permitiendo así el desarrollo de la modelación como una disciplina (ibidem).
Desgraciadamente en lo que respecta al tratamiento de las aguas residuales los diferentes modelos existentes no utilizan los mismos conceptos, los protocolos de identificación de sus parámetros no son estándar y sobre todo sus dominios de validez resultan extremadamente restringidos (ibidem).
Si bien se puede decir que sus teorías y prácticas han cambiado radicalmente en los últimos años, lo que ha evitado su aplicación principalmente en problemas de tipo industrial (aguas residuales industriales) (Fall, 2005).
Un ejemplo claro de dicho aspecto, es que en los modelos más destacados de diseño y operación de bioprocesos para el tratamiento de aguas residuales como el de Mc Carty y Lawrence obvian, generalizan o suponen varios aspectos y valores de parámetros de suma importancia que permiten llevar a cabo una buena predicción en el comportamiento dinámico de los procesos o sistemas, además de no determinar con exactitud la demanda de oxígeno y la producción de lodos para el uso de estos modelos, lo que ha hecho calificarlos como simples y empíricos. Debido a lo anterior, dichos modelos están siendo reemplazados por modelos más sofisticados que permiten entender de manera más detallada los complejos sistemas biológicos (ibidem).
Por su parte, el Activated Sludge Model 1 (ASM1), desarrollado 1987 por el internacional “Task group” creado por la Asociación Internacional de la Calidad del Agua (IAWQ), hoy en día Asociación Internacional del Agua (IWA), es uno de los modelos más innovadores y más aplicados que han dando pauta a un estudio detallado en los sistemas de tratamiento de aguas residuales por lodos activados, al relacionar procesos y componentes implicados, al permitir predecir y comprender de manera real la degradación de la materia orgánica, nitrificación y desnitrificación en los sistemas de lodos activados (Anderson, J. S., et. al., 2000).
Uno de los logros más destacados del grupo fue la integración de los procesos biológicos del modelo y la estandarización de los símbolos, todo esto, mediante la presentación del modelo utilizando una notación matricial, la propuesta de valores de “default” de algunos de los parámetros del modelo, la adopción de la DQO y su fraccionamiento para caracterizar las aguas y lodos, y un código de programación para el desarrollo futuro de software de modelación. La última acción propulsó la existencia actual de varios softwares y programas que tienen implementado en su seno, los conceptos del ASM1 original o algunas de sus modificaciones para fines de diseño, operación de plantas o investigación (Fall y Chávez, 2005).
A partir de la creación del ASM1 se han desarrollado otras generaciones de modelos de la IWA que contemplan además de los establecido en el ASM1, la respiración endógena (ASM3) y la remoción biológica del fósforo (ASM2 y ASM2d) (Anderson, J. S., et. al., 2000).
Para su aplicación es necesario realizar estudios previos como la caracterización de las aguas residuales en base al fraccionamiento de la DQO así como la evaluación de la variación de la carga orgánica en términos de dichas fracciones.
Sin duda con la creación de estos modelos se ha logrado simular dinámicamente los sistemas de tratamiento de lodos activados así como una mayor exactitud de las predicciones y diseño de los mismos.
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ROGEL, DORANTES JAVIER ARTURO 409334 y DORANTES JAVIER ARTURO ROGEL. "Determinación de parámetros cinéticos de un lodo-modelo para estudiar la minimización de los solidos en un proceso biológico de tratamiento de agua residual". Tesis de maestría, Universidad Autonoma del Estado de México, 2013. http://hdl.handle.net/20.500.11799/80311.
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En las plantas de tratamiento de aguas residual, uno de los problemas que ocurren es la producción constante de lodos en exceso. Existen ya estudios y propuestas sobre la minimización de la generación de sólidos en las plantas, como el concepto Cannibal, (variante de lodo activado). Aunque ya hay avances en los conocimientos al respecto. Existe la necesidad de indagar más sobre esta línea. Esta investigación es parte de un proyecto enfocado en el estudio de los procesos de baja producción de lodo (BPL) en el cual se buscan alternativas novedosas. Un punto importante de dicho proyecto es la modelación dinámica para el concepto BPL; Para esto, la investigación se basa en el desarrollo de un lodo modelo con agua sintética, montado en el laboratorio, el cual se caracterizó con estudios físico-químicos y respirometricos. El objetivo de la investigación fue caracterizar el lodo modelo y determinar las constantes cinetecas específicas de este lodo. La metodología utilizada para ello fue llevar a cabo estudios respirometricos para encontrar los parámetros de decaimiento heterótrofo bH, la tasa máxima de crecimiento especifico μHmax, y también evaluar un método alternativo (Incremento de Semillas IS) para determinar μHmax. Las constantes que se determinaron en esta investigación se obtuvieron a 5 temperaturas diferentes 16, 20, 24, 28, y 32oC y para poder estimar el coeficiente de corrección de temperatura (θ), para cada parámetro. Como resultado se pudo estimar el valor de bH a 20oC, siendo 0.62 d-1 mientras que su θ en el rango de 20 a 32oC es 1.06. En el caso de μHmax (por el método de crecimiento) se obtuvo un valor de 4.47 d-1 a 20oC y un θ de 1.057 en el rango de 20 a 28oC. Con respecto al método alternativo incremento de semillas (IS) si se consiguió la linealidad de la función en la que se basa este método, fue confirmada por observaciones en esta investigación, pero no se pudo demostrar la equivalencia de los valores de μHmax medidos por este método con el método tradicional. Los resultados obtenidos dan la certeza a la modelación del proceso BPL que se está desarrollando en el proyecto global.
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Harris, Robert J. S. M. Massachusetts Institute of Technology. "A systematic periodicity and time-variable modulation search in RXTE ASM data : methods, findings, and implications for astrophysical X-ray sources". Thesis, Massachusetts Institute of Technology, 2007. http://hdl.handle.net/1721.1/40898.
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Thesis (S.B.)--Massachusetts Institute of Technology, Dept. of Physics, 2007.Includes bibliographical references (p. 99-106).
In this work, we present the results of a general search for periodicities and for time-variable modulation strength in X-ray sources using data from the All-Sky Monitor onboard the Rossi X-ray Timing Explorer. New findings, including a sharp increase in the modulation of the X-ray flux from the Galactic bulge low-mass X-ray binary GX 9+9 and the recent spin-down event of the pulsar in the high-mass X-ray binary X0114+650, are reported. These searches employed new methods of periodicity detection that employed an algorithm to reduce the effects of low frequency noise from X-ray sources. We discuss these methods and show how they can be used to enhance the signal-to-noise ratio in the Fourier domain for many sources.
by Robert J. Harris.
S.B.
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Cavalcanti, J?ssica Diniz. "Comportamento da atividade el?trica muscular e desempenho de asm?ticos durante o Incremental Shuttle Walking Test e Teste Glittre-AVD". PROGRAMA DE P?S-GRADUA??O EM FISIOTERAPIA, 2017. https://repositorio.ufrn.br/jspui/handle/123456789/23437.
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Os indiv?duos asm?ticos apresentam preju?zos tanto da fun??o muscular respirat?ria, devido as modifica??es da mec?nica ventilat?ria, quanto perif?rica, ocasionada pela altera??es metab?licas com redu??o da capacidade oxidativa. Tais condi??es resulta em aumento da dispneia e fadiga. Como esses m?sculos s?o ativados durante atividades cotidianas nessa popula??o ? indeterminado. O presente trabalho teve como objetivo analisar o comportamento da atividade el?trica dos m?sculos respirat?rios e perif?ricos e o desempenho nos testes de exerc?cio: Incremental Shuttle Walking Test (ISWT) e o teste Glittre-AVD, em indiv?duos asm?ticos versus indiv?duos n?o-asm?ticos. Participaram indiv?duos com diagn?stico cl?nico de asma, de ambos os sexos, com idade entre 20 e 50 anos, doen?a controlada, ?ndice de massa corporal (IMC) abaixo de 30 kg/m?, n?o-fumantes e indiv?duos n?o asm?ticos pareados por idade, sexo e IMC. Ap?s avalia??o inicial, todos os participantes foram submetidos a dois testes de exerc?cio: ISWT e o teste Glittre-AVD. Durante os testes, foram avaliados os m?sculos esternocleidomast?ide (ECOM), escaleno (ESC), reto abdominal (RA) e reto femoral (RF) para o ISWT e ESC, RA, RF e o m?sculo deltoide m?dio (DM) para Glittre-AVD, atrav?s da eletromiografia de superf?cie (EMGs). A an?lise estat?stica foi feita pelo programa estat?stico GraphPad Prism vers?o 6.0, para p<0,05. Foi utilizado o teste Shapiro-Wilk para normalidade das vari?veis estudadas. O teste Mann-Whitney para an?lise intergrupo das vari?veis cardiovasculares, respirat?rias e Borg (dispneia e fadiga). Para an?lise intergrupo da atividade el?trica dos m?sculos estudados, foi utilizado o teste ?t? n?o ? pareado, para o ISWT, e teste Mann-Whitney para o Glittre-AVD. Dezesseis pacientes asm?ticos compuseram o Grupo Asma (GA) e 10 sujeitos n?o-asm?ticos o Grupo Controle (GC). A amostra do GA vs GC apresentaram: idadeanos: 35,31? 11,31 vs 34,70?15,61, IMCkg/m2: 24,49?4,15 vs 22,34?1,797, VEF1%: 78,74?17,41 vs 90,84?7,74 (p<0,01), VEF1/CVF%predito: 84,46?12,53 vs 100,6?8,43 (p<0,01), respectivamente. N?o houve diferen?a na sintomatologia relatada de dispneia e fadiga em membros inferiores, vari?veis cardiorrespirat?rias e capacidade inspirat?ria, entre os grupos, ao final de cada teste. Em rela??o ao desempenho no ISWT, o GA percorreu uma dist?ncia menor que o GC (p<0,05). Para o teste Glittre-AVD, o GA executou o teste com quase 1 minuto a mais comparada ao GC (p<0,05). A an?lise da EMGs durante o ISWT demonstrou aumento da atividade el?trica dos m?sculos avaliados de maneira coordenada e similar, em ambos os grupos, com diferen?a significativamente maior apenas para ECOM do GC em 100% do teste (p<0,05). No Glittre-AVD n?o houve diferen?a de ativa??o para os m?sculos ESC e DM. Os m?sculos RA e RF exibiram uma maior ativa??o no GC, por?m sem diferen?a significativa. Nossos resultados sugerem que durante os testes de exerc?cio ISWT e Glittre-AVD, os pacientes asm?ticos apresentam atividade eletromiogr?fica coordenada e similar aos indiv?duos saud?veis, entretanto com menor desempenho em ambos os testes.
Asthmatic individuals exhibit impairment both respiratory muscle function, due to changes in ventilatory mechanics, and peripheral, caused by metabolic alterations with reduction of oxidative capacity. Such conditions result in increased dyspnea and fatigue. How these muscles are activated during daily activities in this population is undetermined. Thus, the goal of this study was to analyze the behavior of the electrical activity of respiratory and peripheral muscles and performance in exercise tests: Incremental Shuttle Walking Test (ISWT) and Glitter-ADL test in asthmatic subjects comparing with non asthmatic subjects. Participated patients with clinical diagnosis of asthma, of both gender, aged between 20 and 50 years, controlled disease, body mass index (BMI) below 30 kg / m?, non smokers and non asthmatic subjects matched by age, sex and BMI. After initial assessment, all participants were submitted to two exercise tests: ISWT and the Glitter-ADL test. During the tests, were evaluated the sternocleidomastoid (ECOM), scalene (ESC), rectus abdominis (RA) and rectus femoris (RF) muscles for the ISWT and ESC, RA, RF and the middle deltoid (DM) muscle for the Glitter-ADL test, through surface electromyography (EMGs). The statistical analysis was done by the statistical program GraphPad Prism version 6.0, for p <0.05. The Shapiro-Wilk test was used for the normality of the studied variables and Mann-Whitney for intergroup analysis of cardiovascular, respiratory and Borg variables (dyspnea and fatigue). For intergroup analysis of the electrical activity of the muscles studied it was used the unpaired T test for the ISWT and Mann-Whitney test for the Glitter-ADL test. Sixteen asthmatic patients composed the Asthma Group (GA) and ten non-asthatic subjects Control Group (CG). The GA vs GC sample showed: age: 35.31 ? 11.31 vs 34.70 ? 15.61, IMC kg / m2: 24.49 ? 4.15 vs 22.34 ? 1.797, FEV1%: 78.74 ? 17.41 vs 90.84 ? 7.74 (p <0.01), FEV 1 / FVC% predicted: 84.46 ? 12.53 vs 100.6 ? 8.43 (p <0.01), respectively . There was no difference in the reported symptomatology of dyspnea and fatigue in lower limbs, cardiorespiratory variables and inspiratory capacity, between the groups, at the end of each test. Regarding the ISWT performance, the GA walked a distance shorter than the GC (p <0.05). For the Glitter-ADL test, GA performed the test with almost 1 minute more compared to GC (p <0.05). The EMG analysis during the ISWT showed an increase in the electrical activity of the muscles evaluated in a coordinated and similar way, in both groups, with a significant difference only for ECOM of GC in 100% of the test (p <0.05). In Glitter-ADL test, there was no difference in activation for the ESC and DM muscles. The RA and RF muscles showed greater activation in the CG, but no significant difference. Our results suggest that during the ISWT and Glitter-ADL exercise tests, asthmatic patients exhibit coordinated electromyographic activity and similar to healthy individuals, however with lower performances in both tests.
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Lyra, Diego da Silveira. "Anisotropia de Susceptibilidade Magnética (ASM) aplicada ao modelo de posicionamento do Granito Butiá: um granito sintectônico peraluminoso do sul do Brasil". reponame:Biblioteca Digital de Teses e Dissertações da UFRGS, 2018. http://hdl.handle.net/10183/173883.
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O período pós-colisional do Ciclo Brasiliano/Pan-africano é marcado no sul do Brasil pela ocorrência de granitos metaluminosos e peraluminosos, controlados por um sistema transcorrente de zonas de cisalhamento (ZC). No Rio Grande do Sul (RS), a Zona de Cisalhamento Transcorrente Dorsal de Canguçu (ZCTDC), de cinemática sinistral e direção NE, é a principal estrutura que condicionou o posicionamento desses granitos (ca. 634 – 610 Ma). Entretanto, o Granito Butiá (GB – 629 Ma), localizado a noroeste da ZCTDC, ocorre como um corpo alongado de direção NNW que intrude rochas de alto grau metamórfico do Complexo Várzea do Capivarita (ca. 650 Ma). O GB possui trama planar bem desenvolvida (S>L), cuja foliação mergulha com alto ângulo para NNW; apesar de raramente apresentar lineação, seu posicionamento é interpretado como sintectônico a uma ZC transcorrente de cinemática destral. Dessa forma, um estudo de anisotropia de susceptibilidade magnética (ASM) foi realizado no GB, com o objetivo de melhor delimitar os mecanismos de seu posicionamento e relacioná-los com o sistema regional de zonas de cisalhamento. No total, 492 espécimes (180 cilindros) foram coletadas em 16 sítios, distribuídos no corpo principal do GB. A mineralogia magnética foi investigada através de curvas termomagnéticas, curvas de histereses e de aquisição de magnetização remanente isotermal, e detalhada com microscopia eletrônica de varredura em amostras representativas. Essas análises demonstram o domínio de fases paramagnéticas e uma pequena contribuição de minerais de baixa coercividade (e.g., magnetita, titanomagnetita) e alta coercividade (e.g., hematita). Apesar disso, a trama magnética é controlada exclusivamente por cristais paramagnéticos de biotita. A susceptibilidade magnética total é baixa e varia entre 0,1 e 8x10-5 SI. O parâmetro de forma (T) varia de 0,272 a 0,908 e o grau de anisotropia (P) varia de 1,073 a 1,266, aumentando do centro em direção as margens do GB. A presença de par S-C destral de origem magmática e microestruturas de deformação em alta temperatura (~650°C) confirmam que a deformação atuava durante o processo de cristalização. Esses elementos, junto à análise da trama magnética, sugerem que a ascensão e o posicionamento do magma foram controlados por uma ZC transcorrente de direção NNW e cinemática destral. Próximo as rochas encaixantes, os elipsoides magnéticos são fortemente oblatos, a foliação mergulha com alto ângulo para W ou E, e a lineação têm alto a moderado caimento, sugerindo significante achatamento e domínio de uma componente de cisalhamento puro de deformação. Longe das margens, a lineação tem baixos caimentos, paralelos a direção da foliação (NW-NNW), sugerindo um transporte horizontal e domínio de uma componente de cisalhamento simples de deformação, que promoveu o estiramento. No nordeste do corpo, a presença de roof pendants e menores ângulos de mergulho da foliação sugerem proximidade com a cúpula. A combinanção de bouyoancy forces e da partição da deformação regional, em cisalhamento puro e simples durante o posicionamento do GB, está de acordo com um regime transpressivo. Esses resultados também sugerem uma relação no tempo-espaço entre a ZC que controlou o posicionamento do GB e a ZCTDC. Possivelmente, elas formavam um par conjugado do mesmo sistema transcorrente durante o estágio pós-colisional do Ciclo Brasiliano/Pan-africano no sul do Brasil.The post-collisional stage of the Brasiliano/Pan-African Orogenic Cycle in Southern Brazil is marked by metaluminous and peraluminous granites controlled by a transcurrent shear zone system. In the Rio Grande do Sul State, southernmost Brazil, the sinistral, NE-trending Dorsal de Canguçu Transcurrent Shear Zone (DCTSZ) is the best known structure that conditioned these peraluminous granites (ca. 634 – 610 Ma). However, the NNW-elongate Butiá Granite (BG – 629 Ma) is emplaced to the northwest of the DCTSZ, intrusive in the high-grade Várzea do Capivarita Complex (ca. 650 Ma). The BG has a S>L fabric, which foliation steeply dips towards NNW. Despite its poorly-developed linear fabric, BG emplacement is interpreted to have been controlled by a dextral transcurrent shear zone. Thus, anisotropy of magnetic susceptibility (AMS) study was performed in the BG aiming to constrain its emplacement mechanism and the relation of the granite with the regional shear zone system. A total of 492 specimens (180 drill cores) were obtained through 16 sites distributed along the BG main body. Magnetic mineralogy was investigated by hysteresis loops, thermomagnetic and IRM acquisition curves, and a complementary SEM analysis in representative samples. These experiments show a dominant contribution of paramagnetic phases and a small content of low-coercivity (e.g., magnetite and titanomagnetite) and highcoercivity (e.g., hematite) remanence-carrying minerals. In spite of the presence of minor ferromagnetic grains, the BG magnetic anisotropy fabric is interpreted as dominantly controlled by paramagnetic biotite crystals. The bulk magnetic susceptibility ranges between 0.1 and 8.0×10−5 SI. Shape parameter (T) ranges from 0.272 to 0.908, and anisotropy degree (P) ranges from 1.073 to 1.266, increasing from the inner portion of the pluton to its margins. The presence of dextral S-C magmatic fabric and high temperature (ca. 650 °C), solid-state deformation at the margins confirms that the pluton was deformed during its cooling process. Such features, together the magnetic fabric analysis, suggest that magma ascent and emplacement were controlled by a NNW-trending dextral transcurrent shear zone. Close to the host-rocks, magnetic foliation dips steeply towards W or E, and magnetic lineation plunges steeply to moderate, displaying strongly-oblate ellipsoids. This is interpreted as a result of shortening and the significantly pure-shear component of deformation operating close to the host-rocks. Shallow-plunging lineation parallel to the NWto NNW-striking foliation is found away from the pluton margins, which is related to the horizontal displacement, where the simple-shear component of deformation was more effective, resulting stretching. Foliation becomes less steep towards the BG northeastern portion and the presence of roof pendants in this area suggests the proximity to the roof zone. The combination of buoyancy forces and the partitioning of regional strain into simple and pure shear are in accordance with a transpressive regime. These results also suggest a time-space relationship between the NNW-dextral shear zone that controlled the emplacement of the Butiá Granite and the sinistral, NE-trending DCTSZ, responsible for the emplacement of peraluminous granites. Possibly, these zones formed a conjugate pair during the transcurrent deformation of the early post-collisional stage of the Brasiliano/PanAfrican Cycle in southernmost Brazil.
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Benziada, Mébrouk. "Etude hydrogeologique et hydrologique de la plaine de la mitidja-est (application d'un modele mathematique asm au bassin cotier algerois, algerie)". Besançon, 1994. http://www.theses.fr/1994BESA2017.
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Ce travail a pour objectif l'etude hydrogeologique de l'aquifere alluvial de la partie orientale de la mitidja, et comporte trois phases principales: la premiere s'articule sur six chapitres, ou nous examinons les facteurs environnementaux qui affectent l'aire d'etude: la geologie, l'hydrogeologie, l'hydrochimie, l'hydroclimatologie et l'hydrologie de surface, la deuxieme se rapporte a l'analyse correlatoire et spectrale des pluies et debits mettant en evidence les reserves des bassins hydrologiques etudies et a l'application du modele d'ecoulement mero sur le bassin de hammam-melouane (amont atlas blideen) montrant son fonctionnement. L'examen des caracteristiques physiques de ces bassins sont importantes vis a vis de l'amenagement hydraulique. La troisieme est consacree a l'analyse du comportement hydrodynamique de la nappe par une exploitation continue a l'aide d'un modele de simulation mathematique bidimensionnel base sur la methode des differences finies. Ce modele a mis en evidence le destockage de la nappe, ainsi la simulation d'une longue secheresse a montre un abaissement du niveau piezometrique dans le champ captant du hamiz. La recharge de la nappe par une alimentation artificielle a partir des eaux superficielles semble possible et concluante
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Wedeh, Ghaith. "Identification de BRD4 comme nouvelle cible thérapeutique dans le traitement des mastocytoses systémiques agressives (ASM) et des leucémies à mastocytes (MCL)". Thesis, Université Paris-Saclay (ComUE), 2016. http://www.theses.fr/2016SACLS024/document.
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Les mastocytes humains (MC) sont des cellules tissulaires d’origine hématopoïétique impliquées dans une série de processus physiologiques et pathologiques. Les recherches sur les MC ont été entravées pendant longtemps en raison de l'accès limité à des populations pures de ces cellules. Nous avons établi une nouvelle lignée humaine de MC, ROSAKIT WT, dont les propriétés sont similaires à celles des MC primaires, constituant un nouvel outil pour la recherche sur les fonctions des MC humains, et permettant le criblage à haut débit de thérapies anti-allergiques. Les MC sont impliqués dans les mastocytoses, où ils s’accumulent pathologiquement dans divers tissus. Bien que la plupart des cas de mastocytoses systémiques (SM) sont chroniques et indolents, les patients atteints de SM avancée (SM agressive; ASM, et leucémie à mastocytes; MCL) ont un mauvais pronostic, car la plupart des thérapies disponibles ne sont pas curatives. Afin de mieux comprendre la physiopathologie des formes avancées de SM et pour trouver de nouvelles approches pour le traitement, nous avons profité de la disponibilité des cellules ROSAKIT WT pour établir un nouveau sous-clone, la lignée cellulaire ROSAKIT D816V, représentant un équivalent des cellules néoplasiques s’accumulant dans les SM. L'utilisation de cette lignée et de cellules des patients nous a permis d’identifier BRD4 comme une nouvelle cible thérapeutique dans les ASM et les MCL. Nous avons démontré que les MC néoplasiques de patients avec ASM expriment des quantités substantielles de BRD4. Fait intéressant, nous avons aussi démontré que les lignées cellulaires HMC-1 et ROSAKIT D816V expriment aussi BRD4, et que leur prolifération est inhibée par un shRNA BRD4-spécifique. En outre, nous avons montré que le médicament JQ1, inhibiteur de BRD4, induit une inhibition de la croissance et une apoptose dose-dépendante dans les mêmes cellules. De plus, nous avons démontré que JQ1 supprime également la prolifération des MC néoplasiques primaires de patients atteints d’ASM ou de MCL à de faibles concentrations. Enfin, nous avons observé que la midostaurine (PKC412) et l’acide rétinoïque tout-trans (ATRA) coopèrent avec JQ1 pour induire des effets inhibiteurs synergiques sur l’inhibition de la survie des mêmes cellules. En conclusion, nos résultats représentent une avancée sur ce qui était précédemment connu sur l’implication de BRD4 dans les mastocytoses et nous ont permis d'identifier cette protéine comme cible thérapeutique prometteuse dans le traitement des formes avancées de SMHuman mast cells (MCs) are hematopoietic stem cell (HSC)-derived, tissue-resident, multifaceted cells involved in a myriad of physiological and pathological processes. Researches on MCs have been hampered for a long time, due to limited access to pure populations of these cells. We have established a new human MC line, ROSAKIT WT, whose properties are similar to those of primary HSC-derived MCs, providing a novel tool for research on human MC functions, and enabling the high-throughput screening of anti-allergic therapies. Among others, MCs are involved in a group of diseases termed mastocytosis, where they accumulate pathologically in various tissues. Although most cases of systemic mastocytosis (SM) are chronic with an indolent course, patients with advanced SM (aggressive SM; ASM, and mast cell leukemia; MCL) have a reduced life expectancy and a poor prognosis, since most of the therapies already available are not curative. In order to better understand the pathophysiology of advanced SM and to. find new approaches for treatment, we took advantage of the availability of the ROSAKIT WT cells to establish a new subclone, the ROSAKIT D816V cell line, representing a paradigm of the neoplastic cells accumulating in SMUsing these malignant cell line and patients’ cells, we identified the epigenetic reader bromodomain-containing protein-4 (BRD4) as a novel drug target in ASM and MCL. Indeed, we demonstrated that neoplastic MCs from ASM patients expressed substantial amounts of BRD4. Interestingly, we then demonstrated that HMC-1 and ROSAKIT D816V cell lines express BRD4, and that their proliferation is inhibited by a BRD4-specific shRNA. Moreover, we showed that the BRD4-targeting drug JQ1 induced a dose-dependent growth inhibition and apoptosis in the same cells. In addition, we demonstrated that JQ1 suppressed also the proliferation of primary neoplastic MCs of patients with ASM or MCL at low concentrations. Finally, we reported that midostaurin (PKC412) and all-trans retinoic acid (ATRA) cooperated with JQ1 in producing synergistic inhibitory effects on the survival of HMC-1 and ROSA cells. Together, our data represent a significant advance over what was previously known on the involvement of BRD4 in mastocytosis and identify this epigenetic reader bromodomain-containing protein as a promising drug target in advanced SM
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Meurer, Michael, Regina Fölster-Holst, Gottfried Wozel, Gottfried Weidinger, Michael Jünger y Matthias Bräutigam. "Pimecrolimus Cream in the Long-Term Management of Atopic Dermatitis in Adults: A Six-Month Study". Saechsische Landesbibliothek- Staats- und Universitaetsbibliothek Dresden, 2014. http://nbn-resolving.de/urn:nbn:de:bsz:14-qucosa-135596.
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Background: Pimecrolimus cream (Elidel®, SDZ ASM 981), a non-steroid inhibitor of inflammatory cytokines, is effective in the treatment of atopic dermatitis (AD). We assessed whether early treatment of AD signs/symptoms reduces the need for topical corticosteroids. Objective: To investigate the efficacy and safety of pimecrolimus cream 1% in the long-term management of adult AD. Methods: 192 adults with moderate to severe AD were randomised (1:1) for twice daily (b.i.d.) treatment of early signs or symptoms of AD with either pimecrolimus cream 1% or vehicle cream (control group) to prevent progression to flares. Treatment was given as needed for 24 weeks. In the event of flares, a moderately potent corticosteroid (prednicarbate 0.25% cream) was permitted as rescue medication in both groups. The percentage of days on which a topical corticosteroid was used to treat disease flares was the main outcome measure. Results: Corticosteroid medication was used on 14.2% (95% confidence interval, CI: 8.3–21.1) of the days of the 24-week treatment period in the pimecrolimus group and on 37.2% (95% CI: 30.4–44.0) of the days in the control group (p < 0.001). In total, 44.8% (43/96) of patients in the pimecrolimus group did not experience a flare compared with 18.8% (18/96) of patients in the control group. The median time to first flare was 144 days in the pimecrolimus group and 26 days in the control group (p < 0.001). Pimecrolimus treatment was also associated with improvement in signs and symptoms of AD, pruritus, patients’ self-assessment and quality of life. Conclusions: Pimecrolimus cream 1% b.i.d. is an effective, well-tolerated, long-term treatment for AD in adults, substantially reducing the number of flares compared to a conventional therapy and consequently reducing or eliminating the need for corticosteroid treatmentDieser Beitrag ist mit Zustimmung des Rechteinhabers aufgrund einer (DFG-geförderten) Allianz- bzw. Nationallizenz frei zugänglich
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Delgado, Renata N?brega. "Efeitos do treinamento muscular inspirat?rio domiciliar sobre a atividade eletromiogr?fica dos m?sculos respirat?rios em asm?ticos: estudo piloto". Universidade Federal do Rio Grande do Norte, 2013. http://repositorio.ufrn.br:8080/jspui/handle/123456789/16743.
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Previous issue date: 2013-12-13Asthma treatment aims to achieve and maintain the control of the disease for prolonged periods. Inspiratory muscle training (IMT) may be an alternative in the care of patients with asthma, and it is used as a complementary therapy to the pharmacological treatment. Thus, the aim of this study was to investigate the effects of a domiciliary program of IMT on the electromyographic activity of the respiratory muscles in adults with asthma. This is a clinical trial in which ten adults with asthma and ten healthy adults were randomized into two groups (control and training). The electrical activity of inspiratory muscles (sternocleidomastoid (ECM) and diaphragm) was obtained by a surface electromyography. Furthermore, we assessed lung function (spirometry), maximal inspiratory pressure - MIP - (manometer). The functional capacity was evaluated by six minute walk test. Participants were assessed before and after the IMT protocol of 6 weeks with POWERbreathe? device. The training and the control groups underwent IMT with 50% and 15 % of MIP, respectively. The sample data were analyzed using SPSS 20.0, attributing significance of 5 %. Were used t test, ANOVA one way and Pearson correlation. It was observed an increase in MIP, after IMT, in both training groups and in healthy sham group (P < 0.05), which was accompanied by a significant increase in ECM activity during MIP in healthy training group (1488 %) and in asthma training group (ATG) (1186.4%). The ATG also showed a significant increase in diaphragm activity in basal respiration (48.5%). Functional capacity increased significantly in the asthma sham group (26.5 m) and in the asthma training group (45.2 m). These findings suggest that IMT promoted clinical improvements in all groups, especially the ATG, which makes it an important complementary treatment for patients with asthma
O tratamento da asma visa obter e manter o controle da doen?a por per?odos prolongados. O Treinamento Muscular Inspirat?rio (TMI) pode ser uma alternativa na assist?ncia ao paciente asm?tico, sendo utilizado como tratamento complementar ao farmacol?gico Assim, o objetivo deste estudo foi investigar os efeitos de um programa domiciliar de TMI sobre a atividade eletromiogr?fica dos m?sculos respirat?rios em adultos asm?ticos. Trata-se de um ensaio cl?nico em que dez adultos asm?ticos e dez saud?veis foram randomizados em dois grupos (sham e treinamento). A atividade el?trica dos m?sculos inspirat?rios (esternocleidomast?ideo (ECM) e diafragma) foi obtida pela eletromiografia de superf?cie. Al?m disso, foram avaliados a fun??o pulmonar, press?o inspirat?ria m?xima (PIm?x) e capacidade funcional. Os participantes foram avaliados antes e ap?s um protocolo de TMI de 6 semanas. Os grupos treinamento e sham realizaram o TMI com 50% e 15% da PIm?x, respectivamente. Observou-se aumento da PIm?x, ap?s o TMI, nos grupos treinamento e no saud?veis sham (P< 0,05), que foi acompanhado pelo aumento significativo da atividade do ECM durante a PIm?x no grupo treinamento saud?veis (1488%) e no grupo treinamento asm?tico (GTA) (1186,4%). O GTA tamb?m apresentou um aumento significativo da atividade do diafragma na respira??o basal (48,5%). A capacidade funcional aumentou significativamente no grupo sham asm?ticos (26,5m) e no grupo treinamento asm?tico (45,2m). Esses achados sugerem que o TMI promoveu melhoras cl?nicas em todos os grupos, com destaque para o GTA, sendo um op??o n?o farmacol?gica importante para indiv?duos asm?ticos
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Silva, Ada Cristina J?come Sarmento. "Rela??o entre fun??o pulmonar e ?ngulos posturais da coluna cervical e cintura escapular de crian?as asm?ticas respiradores bucais". PROGRAMA DE P?S-GRADUA??O EM FISIOTERAPIA, 2016. https://repositorio.ufrn.br/jspui/handle/123456789/22278.
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Introdu??o: Pacientes asm?ticos apresentam maior tend?ncia a desenvolverem um padr?o respirat?rio predominantemente bucal, e a altera??o do padr?o respirat?rio pela s?ndrome do respirador bucal (SRB) implica em necessidades posturais adaptativas. Objetivo: O prop?sito do presente estudo foi verificar a rela??o entre a fun??o pulmonar e os ?ngulos posturais da coluna cervical e cintura escapular de crian?as asm?ticas respiradores bucais. M?todo: Trata-se de um estudo transversal de car?ter anal?tico, conduzido de acordo com as recomenda??es do STROBE. Foram avaliadas 31 crian?as asm?ticas respiradores bucais com idade compreendida entre 7 e 12 anos. A avalia??o fisioterap?utica constituiu de coleta de dados antropom?tricos, espirometria e para captura dos pontos anat?micos demarcados foi utilizado o Sistema de An?lise do Movimento Qualisys Motion Capture Systems. O Software para Avalia??o Postural (SAPo) foi utilizado para fazer a medida dos ?ngulos posturais da coluna cervical e cintura escapular. Os dados foram analisados atrav?s do software SPSS vers?o 17.0 e n?vel de signific?ncia de 5%. A normalidade de distribui??o dos dados foi testada com o teste de Kolmogorov-Smirnov (KS). A ANOVA one way seguida do Post Hoc Tukey foram utilizados para verificar diferen?as nas angula??es posturais e vari?veis espirom?tricas, nos grupos et?rios entre 7-8; 9-10 e 11-12 anos. O teste de correla??o de Pearson foi realizado para verificar a correla??o entre as vari?veis espirom?tricas (vari?veis dependentes), com as vari?veis independentes: altura, peso e as angula??es posturais. A an?lise de regress?o linear m?ltipla foi realizada para identificar as vari?veis preditoras da fun??o pulmonar de crian?as asm?ticas com padr?o de respira??o bucal. Resultados: As vari?veis protrus?o de ombro esquerdo, capacidade vital for?ada (CVF), volume expirat?rio for?ado no primeiro segundo (VEF1) e pico de fluxo expiat?rio (PFE) apresentaram diferen?as significativas entre os grupos et?rios: 7-8 e 11-12 anos e 9-10 e 11-12 anos. Os modelos de regress?o linear m?ltipla identificaram que: 1) as vari?veis altura, alinhamento de acr?mio direito, alinhamento de acr?mio esquerdo s?o preditores da CVF nas faixas et?rias de 7-8 anos; 2) as vari?veis alinhamento do acr?mio direito, alinhamento do acr?mio esquerdo, protrus?o de ombro direito, protrus?o de ombro esquerdo foram preditores da CVF na faixa-et?ria entre 9-10 anos; 3) alinhamento de acr?mio esquerdo, protrus?o ombro direito e protrus?o ombro esquerdo s?o preditores do VEF1 na faixa et?ria de 9-10 anos; 4) a altura, o alinhamento do acr?mio direito, o alinhamento do acr?mio esquerdo e protrus?o de ombro esquerdo s?o preditores do PFE na faixa et?ria de 9-10 anos. Conclus?o: A protrus?o de ombro esquerdo, CVF, VEF1, fluxo expirat?rio for?ado entre 25% e 75% da CVF (FEF25-75) e PFE podem ser influenciadas pela idade. O peso, altura e ?ngulos posturais cervicais e de cintura escapular s?o preditores da fun??o pulmonar de crian?as asm?ticas respiradores bucais com idade entre 7 e 10 anos.
Introduction: Patients with asthma are more likely to develop a predominantly mouth breathing pattern and a change in the breathing pattern by the mouth breathing syndrome (MBS) implies in postural adjustments. Objective: The purpose of this study was to evaluate the correlation between lung function and postural angles of mouth breathing asthmatic children. Method: This is a crosssectional study of analytical character, conducted in accordance with the STROBE recommendations. 31 mouth breathing asthmatic children aged between 7 and 12 years were evaluated. A speech therapist evaluation was performed which consisted of: Glatzel mirror test; predominantly mouth breathing confirmation during the last six months, and at least one of the following findings: skeletal crossbite, high palate, anterior open bite, shortened upper lip and lower everted and lack of lip seal. The diagnostic confirmation of oral breathing pattern was verified by otoscopy, rhinoscopy, oropharyngoscopy and fibronasopharyngolaryngoscopy. The physical therapy evaluation consisted of anthropometric data, spirometry and assessment of postural pattern by the Qualisys Motion Movement Analysis System Capture Systems. Data were analyzed using SPSS software version 17.0 with a significance level of 5%. The normality distribution of the data was tested with the Kolmogorov-Smirnov (KS) test. The one-way ANOVA followed by Tukey's Post Hoc were used to assess differences in postural angles and spirometric variables in the age groups between 7-8; 9-10 and 11-12 years. Multiple linear regression analysis was performed to identify predictors of lung function of asthmatic children with mouth breathing pattern. Results: The variables left shoulder protrusion, FVC, FEV1 and PEF showed significant differences between the age groups: 7-8 and 11-12 years and 9-10 and 11-12 years. The multiple linear regression models found that: 1) the time variable height, right acromion alignment and left acromion alignment are predictors of FVC in the age groups of 7-8 years; 2) the variable right alignment of the acromion, left alignment acromion, right shoulder protrusion, left shoulder protrusion FVC were predictors in the age group between 9-10 years; 3) Left alignment acromion, right shoulder and left shoulder protrusion are FEV1 predictors aged 9-10 years; 4) the height, right alignment of the acromion, the left alignment of the acromion and left shoulder protrusion are predictors of PFE in the age group of 9-10 years. Conclusion: The left shoulder protrusion, FVC, FEV1, FEF25-75% and PEF may be influenced by age. The weight, height, and the cervical and the shoulder girdle posture angles are predictors of lung function of mouth breathing asthmatic children aged 7 and 10 years.