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Artículos de revistas sobre el tema "Bacterial diseases Interlukins. Bacterial Infections Neutrophil Activation"

Autor: Grafiati
Publicado: 4 de junio de 2021
Última modificación: 7 de febrero de 2022

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1

Cuypers, Fabian, Björn Klabunde, Manuela Gesell Salazar, et al. "Adenosine Triphosphate Neutralizes Pneumolysin-Induced Neutrophil Activation." Journal of Infectious Diseases 222, no. 10 (2020): 1702–12. http://dx.doi.org/10.1093/infdis/jiaa277.

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Abstract Background In tissue infections, adenosine triphosphate (ATP) is released into extracellular space and contributes to purinergic chemotaxis. Neutrophils are important players in bacterial clearance and are recruited to the site of tissue infections. Pneumococcal infections can lead to uncontrolled hyperinflammation of the tissue along with substantial tissue damage through excessive neutrophil activation and uncontrolled granule release. We aimed to investigate the role of ATP in neutrophil response to pneumococcal infections. Methods Primary human neutrophils were exposed to the pneu
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2

Fontoura, Marina Alves, Rebeca Fróes Rocha, and Rafael Elias Marques. "Neutrophil Recruitment and Participation in Severe Diseases Caused by Flavivirus Infection." Life 11, no. 7 (2021): 717. http://dx.doi.org/10.3390/life11070717.

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Neutrophils are first-line responders to infections and are recruited to target tissues through the action of chemoattractant molecules, such as chemokines. Neutrophils are crucial for the control of bacterial and fungal infections, but their role in the context of viral infections has been understudied. Flaviviruses are important human viral pathogens transmitted by arthropods. Infection with a flavivirus may result in a variety of complex disease manifestations, including hemorrhagic fever, encephalitis or congenital malformations. Our understanding of flaviviral diseases is incomplete, and
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3

Al Moussawi, Khatoun, та Barbara I. Kazmierczak. "Distinct Contributions of Interleukin-1α (IL-1α) and IL-1β to Innate Immune Recognition of Pseudomonas aeruginosa in the Lung". Infection and Immunity 82, № 10 (2014): 4204–11. http://dx.doi.org/10.1128/iai.02218-14.

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ABSTRACTThe bacterial pathogenPseudomonas aeruginosacauses acute infections associated with significant morbidity and mortality.P. aeruginosaelicits strong innate immune responses in immunocompetent hosts, and the resulting recruitment of neutrophils to the site of infection is necessary for bacterial clearance.P. aeruginosalipopolysaccharide and flagellin are recognized by extracellular Toll-like receptors, but the most rapid responses to infection occur when cytosolic receptors sense flagellin or type 3 secretion system (T3SS) structural proteins. The subsequent activation of the NLRC4 infla
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4

Leid, Jeff G., Mathias Kerr, Candice Selgado, et al. "Flagellum-Mediated Biofilm Defense Mechanisms of Pseudomonas aeruginosa against Host-Derived Lactoferrin." Infection and Immunity 77, no. 10 (2009): 4559–66. http://dx.doi.org/10.1128/iai.00075-09.

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ABSTRACT Chronic infection with the gram-negative organism Pseudomonas aeruginosa is a leading cause of morbidity and mortality in human patients, despite high doses of antibiotics used to treat the various diseases this organism causes. These infections are chronic because P. aeruginosa readily forms biofilms, which are inherently resistant to antibiotics as well as the host's immune system. Our laboratory has been investigating specific mutations in P. aeruginosa that regulate biofilm bacterial susceptibility to the host. To continue our investigation of the role of genetics in bacterial bio
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5

Marin-Esteban, Viviana, Isabelle Turbica, Guillaume Dufour, et al. "Afa/Dr Diffusely Adhering Escherichia coli Strain C1845 Induces Neutrophil Extracellular Traps That Kill Bacteria and Damage Human Enterocyte-Like Cells." Infection and Immunity 80, no. 5 (2012): 1891–99. http://dx.doi.org/10.1128/iai.00050-12.

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ABSTRACTWe recently documented the neutrophil response to enterovirulent diffusely adherentEscherichia coliexpressing Afa/Dr fimbriae (Afa/Dr DAEC), using the human myeloid cell line PLB-985 differentiated into fully mature neutrophils. Upon activation, particularly during infections, neutrophils release neutrophil extracellular traps (NETs), composed of a nuclear DNA backbone associated with antimicrobial peptides, histones, and proteases, which entrap and kill pathogens. Here, using fluorescence microscopy and field emission scanning electron microscopy, we observed NET production by PLB-985
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6

Didierlaurent, Arnaud, John Goulding, Seema Patel, et al. "Sustained desensitization to bacterial Toll-like receptor ligands after resolutionof respiratory influenza infection." Journal of Experimental Medicine 205, no. 2 (2008): 323–29. http://dx.doi.org/10.1084/jem.20070891.

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The World Health Organization estimates that lower respiratory tract infections (excluding tuberculosis) account for ∼35% of all deaths caused by infectious diseases. In many cases, the cause of death may be caused by multiple pathogens, e.g., the life-threatening bacterial pneumonia observed in patients infected with influenza virus. The ability to evolve more efficient immunity on each successive encounter with antigen is the hallmark of the adaptive immune response. However, in the absence of cross-reactive T and B cell epitopes, one lung infection can modify immunity and pathology to the n
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7

Singel, Kelly L., and Brahm H. Segal. "NOX2-dependent regulation of inflammation." Clinical Science 130, no. 7 (2016): 479–90. http://dx.doi.org/10.1042/cs20150660.

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NADPH oxidase (NOX) isoforms together have multiple functions that are important for normal physiology and have been implicated in the pathogenesis of a broad range of diseases, including atherosclerosis, cancer and neurodegenerative diseases. The phagocyte NADPH oxidase (NOX2) is critical for antimicrobial host defence. Chronic granulomatous disease (CGD) is an inherited disorder of NOX2 characterized by severe life-threatening bacterial and fungal infections and by excessive inflammation, including Crohn's-like inflammatory bowel disease (IBD). NOX2 defends against microbes through the direc
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8

Lee, Sang-C., Seong-A. Ju, Ha-N. Pack, et al. "4-1BB (CD137) Is Required for Rapid Clearance of Listeria monocytogenes Infection." Infection and Immunity 73, no. 8 (2005): 5144–51. http://dx.doi.org/10.1128/iai.73.8.5144-5151.2005.

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ABSTRACT 4-1BB (CD137), a member of the tumor necrosis factor receptor superfamily, is a T-cell-costimulatory receptor that is expressed on activated T cells, dendritic cells, and NK cells. Little has been reported about its role in early host defense against bacterial infection. In this study, we report that 4-1BB-deficient (4-1BB−/−) mice are much more susceptible to Listeria monocytogenes (intracellular bacteria) infections than wild-type mice. Upon L. monocytogenes infection, 4-1BB−/− mice showed a lower survival rate, a higher bacterial burden in organs, and larger hepatic microabscesses
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9

Zurita, E., G. Moreno, A. Errea, M. Ormazabal, M. Rumbo, and D. Hozbor. "The Stimulated Innate Resistance Event in Bordetella pertussis Infection Is Dependent on Reactive Oxygen Species Production." Infection and Immunity 81, no. 7 (2013): 2371–78. http://dx.doi.org/10.1128/iai.00336-13.

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ABSTRACTThe exacerbated induction of innate immune responses in airways can abrogate diverse lung infections by a phenomenon known as stimulated innate resistance (StIR). We recently demonstrated that the enhancement of innate response activation can efficiently impairBordetella pertussiscolonization in a Toll-like receptor 4 (TLR4)-dependent manner. The aim of this work was to further characterize the effect of lipopolysaccharide (LPS) on StIR and to identify the mechanisms that mediate this process. Our results showed that bacterial infection was completely abrogated in treated mice when the
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10

Teske, Sabine, Andrea A. Bohn, Jean F. Regal, Joshua J. Neumiller, and B. Paige Lawrence. "Activation of the aryl hydrocarbon receptor increases pulmonary neutrophilia and diminishes host resistance to influenza A virus." American Journal of Physiology-Lung Cellular and Molecular Physiology 289, no. 1 (2005): L111—L124. http://dx.doi.org/10.1152/ajplung.00318.2004.

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Unlike their role in bacterial infection, less is known about the role of neutrophils during pulmonary viral infection. Exposure to pollutant 2,3,7,8-tetrachlorodibenzo- p-dioxin (TCDD, dioxin) results in excess neutrophils in the lungs of mice infected with influenza A virus. TCDD is the most potent agonist for the aryl hydrocarbon receptor (AhR), and exposure to AhR ligands has been correlated with exacerbated inflammatory lung diseases. However, knowledge of the effects of AhR agonists on neutrophils is limited. Likewise, the factors regulating neutrophil responses during respiratory viral
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11

Giam, Yan Hui, Amelia Shoemark, and James D. Chalmers. "Neutrophil dysfunction in bronchiectasis: an emerging role for immunometabolism." European Respiratory Journal 58, no. 2 (2021): 2003157. http://dx.doi.org/10.1183/13993003.03157-2020.

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Bronchiectasis is a heterogenous disease with multiple underlying causes. The pathophysiology is poorly understood but neutrophilic inflammation and dysfunctional killing of pathogens is believed to be key. There are, however, no licensed therapies for bronchiectasis that directly target neutrophilic inflammation. In this review, we discuss our current understanding of neutrophil dysfunction and therapeutic targeting in bronchiectasis. Immunometabolic reprogramming, a process through which inflammation changes inflammatory cell behaviour by altering intracellular metabolic pathways, is increas
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12

Linge, Helena M., Mattias Collin, Pontus Nordenfelt, Matthias Mörgelin, Martin Malmsten, and Arne Egesten. "The Human CXC Chemokine Granulocyte Chemotactic Protein 2 (GCP-2)/CXCL6 Possesses Membrane-Disrupting Properties and Is Antibacterial." Antimicrobial Agents and Chemotherapy 52, no. 7 (2008): 2599–607. http://dx.doi.org/10.1128/aac.00028-08.

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ABSTRACT Granulocyte chemotactic protein 2 (GCP-2)/CXCL6 is a CXC chemokine expressed by macrophages and epithelial and mesenchymal cells during inflammation. Through binding and activation of its receptors (CXCR1 and CXCR2), it exerts neutrophil-activating and angiogenic activities. Here we show that GCP-2/CXCL6 itself is antibacterial. Antibacterial activity against gram-positive and gram-negative pathogenic bacteria of relevance to mucosal infections was seen at submicromolar concentrations (minimal bactericidal concentration at which 50% of strains tested were killed, 0.063 ± 0.01 to 0.37
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13

Ribes, Sandra, Sandra Ebert, Dirk Czesnik та ін. "Toll-Like Receptor Prestimulation Increases Phagocytosis of Escherichia coli DH5α and Escherichia coli K1 Strains by Murine Microglial Cells". Infection and Immunity 77, № 1 (2008): 557–64. http://dx.doi.org/10.1128/iai.00903-08.

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ABSTRACT Meningitis and meningoencephalitis caused by Escherichia coli are associated with high rates of mortality. When an infection occurs, Toll-like receptors (TLRs) expressed by microglial cells can recognize pathogen-associated molecular patterns and activate multiple steps in the inflammatory response that coordinate the brain's local defense, such as phagocytosis of invading pathogens. An upregulation of the phagocytic ability of reactive microglia could improve the host defense in immunocompromised patients against pathogens such as E. coli. Here, murine microglial cultures were stimul
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14

Ketter, Patrick M., M. Neal Guentzel, Beverly Schaffer, et al. "Severe Acinetobacter baumannii Sepsis Is Associated with Elevation of Pentraxin 3." Infection and Immunity 82, no. 9 (2014): 3910–18. http://dx.doi.org/10.1128/iai.01958-14.

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ABSTRACTMultidrug-resistantAcinetobacter baumanniiis among the most prevalent bacterial pathogens associated with trauma-related wound and bloodstream infections. Although septic shock and disseminated intravascular coagulation have been reported following fulminantA. baumanniisepsis, little is known about the protective host immune response to this pathogen. In this study, we examined the role of PTX3, a soluble pattern recognition receptor with reported antimicrobial properties and stored within neutrophil granules. PTX3 production by murine J774a.1 macrophages was assessed following challen
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15

Cross, A. L., J. Hawkes, H. L. Wright, R. J. Moots та S. W. Edwards. "APPA (apocynin and paeonol) modulates pathological aspects of human neutrophil function, without supressing antimicrobial ability, and inhibits TNFα expression and signalling". Inflammopharmacology 28, № 5 (2020): 1223–35. http://dx.doi.org/10.1007/s10787-020-00715-5.

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Abstract Neutrophils are key players in the pathophysiological process underlying inflammatory conditions not only by release of tissue-damaging cytotoxic enzymes, reactive oxygen species (ROS) but also by secretion of important immunomodulatory chemokines and cytokines. Here, we report the effects of the novel agent APPA, undergoing formal clinical development for treatment of osteoarthritis, and its constituent components, apocynin (AP) and paeonol (PA) on a number of neutrophil functions, including effects on TNFα- expression and signalling. Neutrophils were treated with APPA (10–1000 µg/mL
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16

Blomgran, Robert, Limin Zheng, and Olle Stendahl. "Uropathogenic Escherichia coli Triggers Oxygen-Dependent Apoptosis in Human Neutrophils through the Cooperative Effect of Type 1 Fimbriae and Lipopolysaccharide." Infection and Immunity 72, no. 8 (2004): 4570–78. http://dx.doi.org/10.1128/iai.72.8.4570-4578.2004.

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ABSTRACT Type 1 fimbriae are the most commonly expressed virulence factor on uropathogenic Escherichia coli. In addition to promoting avid bacterial adherence to the uroepithelium and enabling colonization, type 1 fimbriae recruit neutrophils to the urinary tract as an early inflammatory response. Using clinical isolates of type 1 fimbriated E. coli and an isogenic type 1 fimbria-negative mutant (CN1016) lacking the FimH adhesin, we investigated if these strains could modulate apoptosis in human neutrophils. We found that E. coli expressing type 1 fimbriae interacted with neutrophils in a mann
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17

Kaufmann, A., P. F. Mühlradt, D. Gemsa, and H. Sprenger. "Induction of Cytokines and Chemokines in Human Monocytes by Mycoplasma fermentans-Derived Lipoprotein MALP-2." Infection and Immunity 67, no. 12 (1999): 6303–8. http://dx.doi.org/10.1128/iai.67.12.6303-6308.1999.

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ABSTRACT Bacterial infections are characterized by strong inflammatory reactions. The responsible mediators are often bacterially derived cell wall molecules, such as lipopolysaccharide or lipoteichoic acids, which typically stimulate monocytes and macrophages to release a wide variety of inflammatory cytokines and chemokines. Mycoplasmas, which lack a cell wall, may also stimulate monocytes very efficiently. This study was performed to identify mycoplasma-induced mediators. We investigated the induction of cytokines and chemokines in human monocytes exposed to the Mycoplasma fermentans-derive
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18

Freedman, Jane. "Toll-Like Receptors: Mechanism and Relation to Human Populations." Blood 128, no. 22 (2016): SCI—46—SCI—46. http://dx.doi.org/10.1182/blood.v128.22.sci-46.sci-46.

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Abstract Inflammation and infection are known to alter platelet count, production, and function and major studies have demonstrated that acute infection is associated with a transient 5-fold increased risk of thrombotic vascular syndromes including stroke, acute myocardial infarction, and peripheral vascular occlusion. Platelets play an intricate role in thrombosis, myocardial infarction, and thrombotic stroke and are now being appreciated for their functional innate immune receptors. More recently, platelets have been connected to the host's immune system via their ability to trap bacteria an
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19

DeZern, Amy E., Donna Dorr, and Robert A. Brodsky. "Predictors of Response to Eculizumab Therapy in Paroxysmal Nocturnal Hemoglobinuria." Blood 120, no. 21 (2012): 2357. http://dx.doi.org/10.1182/blood.v120.21.2357.2357.

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Abstract Abstract 2357 Paroxysmal nocturnal hemoglobinuria (PNH) is a rare, clonal, hematopoietic stem cell disorder that manifests with a hemolytic anemia, bone marrow failure and thrombophilia. Eculizumab is an FDA-approved humanized monoclonal antibody for treatment of PNH that has been shown to improve anemia, decrease intravascular hemolysis, reduce risk of thrombosis, and improve quality of life. The quality of response to eculizumab is quite variable, especially with respect to normalization of hemoglobin levels. Thus, it is important to identify the factors that predict response to ecu
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20

Williams, Jonathan G., Diane Ly, Nicholas J. Geraghty, et al. "Streptococcus pyogenes M1T1 Variants Induce an Inflammatory Neutrophil Phenotype Including Activation of Inflammatory Caspases." Frontiers in Cellular and Infection Microbiology 10 (January 28, 2021). http://dx.doi.org/10.3389/fcimb.2020.596023.

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Invasive infections due to group A Streptococcus (GAS) advance rapidly causing tissue degradation and unregulated inflammation. Neutrophils are the primary immune cells that respond to GAS. The neutrophil response to GAS was characterised in response to two M1T1 isolates; 5448 and animal passaged variant 5448AP. Co-incubation of neutrophils with 5448AP resulted in proliferation of GAS and lowered the production of reactive oxygen species when compared with 5448. Infection with both strains invoked neutrophil death, however apoptosis was reduced in response to 5448AP. Both strains induced neutr
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21

Pang, Zheng, Renee Raudonis, Craig McCormick, and Zhenyu Cheng. "Early Growth Response 1 Deficiency Protects the Host against Pseudomonas aeruginosa Lung Infection." Infection and Immunity 88, no. 1 (2019). http://dx.doi.org/10.1128/iai.00678-19.

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ABSTRACT Pseudomonas aeruginosa is an opportunistic pathogen that is a common cause of nosocomial infections. The molecular mechanisms governing immune responses to P. aeruginosa infection remain incompletely defined. Early growth response 1 (Egr-1) is a zinc-finger transcription factor that controls inflammatory responses. Here, we characterized the role of Egr-1 in host defense against P. aeruginosa infection in a mouse model of acute bacterial pneumonia. Egr-1 expression was rapidly and transiently induced in response to P. aeruginosa infection. Egr-1-deficient mice displayed decreased mort
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22

Lausen, Mads, Mathilde Selmar Pedersen, Nareen Sherzad Kader Rahman, et al. "Opsonophagocytosis of Chlamydia pneumoniae by Human Monocytes and Neutrophils." Infection and Immunity 88, no. 7 (2020). http://dx.doi.org/10.1128/iai.00087-20.

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ABSTRACT The human respiratory tract pathogen Chlamydia pneumoniae, which causes mild to severe infections, has been associated with the development of chronic inflammatory diseases. To understand the biology of C. pneumoniae infections, several studies have investigated the interaction between C. pneumoniae and professional phagocytes. However, these studies have been conducted under nonopsonizing conditions, making the role of opsonization in C. pneumoniae infections elusive. Thus, we analyzed complement and antibody opsonization of C. pneumoniae and evaluated how opsonization affects chlamy
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