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1

Detwiler, Zachary, and Snehal N. Chaudhari. "BAAT away liver cancer: conjugated bile acids impair T cell function in hepatocellular carcinoma immunotherapy." Immunometabolism 7, no. 2 (2025): e00062. https://doi.org/10.1097/in9.0000000000000062.

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In this renaissance era of gene therapy, a new study published by the Susan Kaech lab in Science demonstrates the use of CRISPR-Cas9 technology to selectively deplete conjugated bile acids in the liver by targeting the bile acid–CoA:amino acid N-acyltransferase (Baat) gene to improve responsiveness to immunotherapy. This study highlights the role of conjugated bile acids in impairing intratumoral T cell function by directly accumulating in resident liver T cells and driving mitochondrial dysfunction. Knockout of Baat reduced hepatic conjugated bile acid production, thus improving immunotherapy
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2

Er, Sadettin, Mehmet Tahtabaşı, Sh Ibrahim Ikram Abdikarim, Ali Ismail Ahmed, and Ibrahim Ismail Gedi. "Bile Duct Exploration and T-tube Drainage Procedure without Endoscopic Retrograde Cholangiopancreatography (ERCP) Unit in Somalia." Life and Medical Sciences 1, no. 1 (2020): 14–19. https://doi.org/10.54584/lms.2022.2.

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<strong>&Ouml;zet</strong> &Ccedil;alışmamızda, ERCP (endoskopik retrograd kolanjiopankreatografi) yapılamayan koledokolithiyazisli hastalarda a&ccedil;ık olarak yapılan T-t&uuml;p drenaj prosed&uuml;r&uuml;n&uuml; değerlendirmek ama&ccedil;lanmıştır. Hastaların yaş, cinsiyet, laboratuvar değerleri, hastanede yatış s&uuml;resi, T-t&uuml;p &ccedil;ekilme zamanı ve tedaviye yanıtları elektronik kayıtlarından alındı. Preoperatif d&ouml;nemde t&uuml;m hastalar MRCP (magnetik rezonans kolanjio pankreatigografi) ile değerlendirildi. Toplam 16 hastanın 11 (%68.8)&rsquo;i kadın ve beşi (%31.2)&rsquo;i
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3

Yaremenko, Vasyl. "SHEVCHENKO'S WORK "BETWEEN THE ROCKS, LIKE A THIEF..." IN THE PERSPECTIVE OF CHRISTIAN COMMANDMENTS AND HONESTY." Shevchenko Studies, no. 1 (27) (2024): 301–31. https://doi.org/10.17721/2410-4094.2024.1(27).2/301-331.

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I n t r o d u c t i o n . The relevance is due to the fact that modern civilization is gradually losing its Christian foundations and through the creativity of great writers people need to be reminded of them in order to convey their moral and ethical zeal. M e t h o d s . The study is based on textual, in particular lexical, analysis of the work in comparison with other texts by Shevchenko and Christian literature (the Bible, works of the Church Fathers, etc.). The main focus is on Christian precepts. R e s u l t s . In the statistic, which is transferred to the lexical level and from the rec
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4

Er, Sadettin, Mehmet Tahtabaşı, Sh Ibrahim Ikram Abdikarim, Ali Ismail Ahmed, and Ibrahim Ismail Gedi. "Bile Duct Exploration and T-tube Drainage Procedure without Endoscopic Retrograde Cholangiopancreatography (ERCP) Unit in Somalia." Life and Medical Sciences 1, no. 1 (2020): 14–19. https://doi.org/10.5281/zenodo.5656737.

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<strong>&Ouml;zet</strong> &Ccedil;alışmamızda, ERCP (endoskopik retrograd kolanjiopankreatografi) yapılamayan koledokolithiyazisli hastalarda a&ccedil;ık olarak yapılan T-t&uuml;p drenaj prosed&uuml;r&uuml;n&uuml; değerlendirmek ama&ccedil;lanmıştır. Hastaların yaş, cinsiyet, laboratuvar değerleri, hastanede yatış s&uuml;resi, T-t&uuml;p &ccedil;ekilme zamanı ve tedaviye yanıtları elektronik kayıtlarından alındı. Preoperatif d&ouml;nemde t&uuml;m hastalar MRCP (magnetik rezonans kolanjio pankreatigografi) ile değerlendirildi. Toplam 16 hastanın 11 (%68.8)&rsquo;i kadın ve beşi (%31.2)&rsquo;i
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5

Gurbanov, G. R., A. V. Gasimzade, and L. A. Abbasova. "STUDY OF THE EFFECT OF PHYSİCO-CHEMİCAL PROPERTİES ON THE RHEOLOGİCAL PROPERTİES OF HİGH-PARAFFİN OİLS." Energy Technologies & Resource Saving 79, no. 2 (2024): 35–44. http://dx.doi.org/10.33070/etars.2.2024.03.

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For the first time, the joint effect of magnetic field, Difron-4201 depressor additive, new composition with conventional name N-1 and N-1 + magnetic field on paraffin deposition and freezing temperature in high-paraffin oil was studied. Laboratory experiments on paraffin deposition were performed by the “cold tube” method and the surface temperature of the tube was 5, 10, 15, 20, and 25 °C. The greatest decrease in the amount of paraffin deposits at different temperatures was caused by the influence of the combined method. The physical, chemical and physico-chemical effect on the freezing tem
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6

Seervi, Manoj, Deepak Verma, Nemi Chand, and Sarthak Sharma. "Primary closure of common bile duct versus T-tube placement after open choledocholithotomy." International Surgery Journal 7, no. 6 (2020): 1951. http://dx.doi.org/10.18203/2349-2902.isj20202411.

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Background: Choledocholithiasis is primarily managed by endoscopic retrograde cholangiopancreatography (ERCP) but in certain situation particularly large and impacted common duct stone, the procedure may not succeed and this small group of patients require either open or laparoscopic common bile duct exploration followed by T-tube insertion. Usually T-Tube cholangiogram is performed on 10th postoperative day and tube is removed on 12-14th day. Alternatively, primary closure of duct after post exploratory choledochoscopy to ensure duct clearance with or without biliary stent can be done.Methods
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7

Ide, T., S. Kano, M. Murata, T. Yanagita, and M. Sugano. "Dietary modifications of the biliary bile acid glycine: taurine ratio and activity of hepatic bile acid-CoA:amino acid N-acyltransferase (EC 2.3.1) in the rat." British Journal of Nutrition 72, no. 1 (1994): 93–100. http://dx.doi.org/10.1079/bjn19940012.

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Effects of dietary manipulations on the biliary bile acid glycine: taurine (G: T) ratio and the activity of hepatic bile acid-Co A: amino acidN-acyltransferase (EC 2.3.1) in the post-mitochondrial fraction of liver homogenates were examined in the rat. The G:T ratio in rats fed on the diet containing 100 g pectin/kg (2.18) was markedly higher than that in the animals fed on the diet containing 100 g cellulose/kg (0.09). The diets containing either 10 g cholesterol/kg or 5 g sodium cholate/kg, especially the latter, also increased the G:T ratio (0.77 and 2.33 respectively) compared with a contr
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8

Zhou, Yong, Xu-Dong Wu, Wen-Zhang Zha, et al. "Three modalities on common bile duct exploration." Zeitschrift für Gastroenterologie 55, no. 09 (2017): 856–60. http://dx.doi.org/10.1055/s-0043-112655.

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Abstract Background Choledocholithiasis can be managed by transcystic (TC) and transduct (TD) stone extraction or using cholangioscopy through the left hepatic duct orifice (LHD). Objective The aim of this study is to evaluate the safety and effectiveness of common bile duct exploration through the TC approach, TD approach, and LHD approach for choledocholithiasis, with a specific emphasis on the TC and LHD approaches versus the TD approach. Methods Between January 2011 and June 2014, a total of 172 choledocholithiasis patients accompanied by cholecystitis and/or left intrahepatic gallstones w
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9

AKRAM, MUHAMMAD, UMER FAROOQ, MUHAMMAD REHMAN GULZAR, Muhammad Ajmal Khan, and Javaid Iqbal. "LAPAROSCOPIC CHOLECYSTECTOMY." Professional Medical Journal 16, no. 02 (2009): 221–23. http://dx.doi.org/10.29309/tpmj/2009.16.02.2905.

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O b j e c t i v e : To determine the frequency of bleeding, surgical site infection and common bile duct injury after laparoscopicCholecystectomy in patients with co-morbidity. S t u d y d e s i g n : Descriptive study. (Case series). S e t t i n g : Department of Allied &amp; D.H.Qhospital Faisalabad. P e r i o d : July 2006 to December 2007. Patients a n d M e t h o d s : It comprised of 30 consecutive patients of cholelithiasiswith co-morbidity presenting in surgical department. Patients having uncontrolled hypertension, chronic obstructive airway disease andmalignancy were excluded. Detail
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10

Sorochinsky, Gleb Romanovich. "Semantics and Function of Stelae in the Ancient Architecture of the Near East in the Era from the Neolithic Man to the Epic Gilgamesh and the Biblical Jacob." Культура и искусство, no. 8 (August 2023): 74–85. http://dx.doi.org/10.7256/2454-0625.2023.8.39760.

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The subject of the study is such a phenomenon in the cult architecture of the Near East region (Levant, Mesopotamia, Anatolia, Elam) as the erection of stelae. Special attention is paid to the semantics of stelae, which had a sacred meaning for ancient people. The purpose of the research is to identify the main functions and meanings characteristic of such a typological unit in the architecture of the Near East as the stela (stele). The relevance of the research is determined by the development of interdisciplinary discourse in this issue among domestic (N. Ya. Merpet, E. V. Antonova, A. B. Zu
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11

Wise, Paul E., L. James Wudel, Andrey E. Belous, et al. "Biliary Reconstruction is Enhanced with a Collagen-Polyethylene Glycol Sealant." American Surgeon 68, no. 6 (2002): 553–62. http://dx.doi.org/10.1177/000313480206800609.

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Bile leaks occur in up to 27 per cent of liver transplant patients after biliary reconstruction. Synthetic sealants have not been investigated for these biliary procedures. We performed a randomized controlled study to evaluate a novel absorbable polyethylene glycol/collagen bio-polymer sealant (CT3™ Surgical Sealant) after incomplete end-to-end choledochocholedochostomy (CDCD) in pigs. Pigs (n = 18) underwent transection of the common bile duct and incomplete CDCD over a T-tube, leaving a one-sixth circumferential defect anteriorly. Animals were randomly assigned to treatment (CDCD with seala
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12

ERDMANN, J. J., J. S. DICKSON, and M. A. GRANT. "A New Technique for Escherichia coli Testing of Beef and Pork Carcasses†." Journal of Food Protection 65, no. 1 (2002): 192–95. http://dx.doi.org/10.4315/0362-028x-65.1.192.

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A novel technique has been developed to monitor Escherichia coli contamination on carcasses using membrane filtration and m-ColiBlue24 (mCB). mCB is a membrane filtration medium that simultaneously detects total coliforms and E. coli (EC) in a period of 24 ± 4 h. A study was conducted, using a sponge method to obtain samples from pork carcasses and the excision technique to remove samples from beef carcasses, that compared mCB to standard methods. On pork carcasses (n = 77), the mean values for mCB and violet red bile agar were 7.4 CFU/15 cm2 and 6.1 CFU/15 cm2, respectively. The paired t test
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13

Shanta, Tamanna Rahman, Md Abul Kalam Azad, Mahedi Afroz Shakil, et al. "Comparison of Primary Closure and T-tube Drainage after Open Choledocholithotomy." Asian Journal of Medicine and Health 23, no. 7 (2025): 113–19. https://doi.org/10.9734/ajmah/2025/v23i71270.

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Background: Choledocholithotomy followed by closure over a T-tube has long been a standard surgical treatment for choledocholithiasis. However, several authors have supported the primary closure of the duct immediately after exploration. This study was conducted to compare the clinical short-term outcomes of primary closure of the common bile duct and T-tube drainage. Methods: This prospective comparative study was conducted at the Department of Surgery, Mymensingh Medical College and Hospital, from January 2021 to June 2022. A total of 50 clinically diagnosed cases of choledocholithiasis pati
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14

Al-Shuwaili, Thamer, Mushtak Talib Mohammadali, Adnan A. Lahuf, Manjree Agarwal, and Pushpendra Koli. "Study on metabolic response of female and male Trogoderma varia-bile (Ballion) on different host grain using direct immersion solid-phase microextraction coupled with gas chromatography mass." Journal of Kerbala for Agricultural Sciences 11, no. 1 (2024): 14–30. http://dx.doi.org/10.59658/jkas.v11i1.1426.

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The purpose of this study is to use the technique of gas chromatography coupled with mass spectrometry to study the metabolite profile of Trogoderma variabile using different host grains including canola, oats, wheat, and barley. Also, hydrocarbon profiling can be used as a chemo-taxonomical tool for insect species identification, especially for very morphologically similar species like T. granarium. For sample preparation insects were subjected to extraction with acetonitrile. Direct Immersion-Solid Phase Microextraction (DI-SPME) was employed, followed by Gas Chromatography-Mass Spectrometry
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15

Darenskaya, Marina A., Liubov I. Kolesnikova, Olga V. Smirnova, Boris G. Gubanov, Edward V. Kasparov, and Sergei I. Kolesnikov. "Neutrophils’ functional activity in patients with mechanical jaundice and different levels of bilirubin." Biomedical Research and Therapy 8, no. 6 (2021): 4417–22. http://dx.doi.org/10.15419/bmrat.v8i6.679.

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Introduction: Mechanical jaundice (MJ) or bile duct blockage occurs when the bile ducts' patency is impaired, and the bile flow has stopped. One of the main pathogenetic factors developing complications with MJ is immune system imbalance, particularly its phagocytic link. The purpose of the study was to understand neutrophils' functional activity dependence with different blood bilirubin levels in men with mechanical jaundice.&#x0D; Methods: Forty-seven middle-aged men with mechanical jaundice were divided into three groups depending on the bilirubin levels in their blood: less than 60 μmol/L
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16

Färkkilä, M. A., K. J. Kairemo, M. J. Taavitsainen, T. A. Strandberg, and T. A. Miettinen. "Plasma Lathosterol as a Screening Test for Bile Acid Malabsorption Due to Ileal Resection: Correlation with 75SeHCAT Test and Faecal Bile Acid Excretion." Clinical Science 90, no. 4 (1996): 315–19. http://dx.doi.org/10.1042/cs0900315.

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1. Plasma lathosterol concentration, known to reflect cholesterol and bile acid synthesis, was evaluated as a screening test for bile acid malabsorption, comparing it with faecal bile acid measurements, SeHCAT test and Schilling test in 22 subjects of whom six were healthy controls and 16 had Crohn's disease with ileal resections of varying length. 2. Plasma lathosterols and other non-cholesterol sterols were determined by GLC. Faecal bile acids were measured by GLC, and SeHCAT retention times by gamma camera. The study subjects were divided into two groups according to the degree of bile acid
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17

Hossen, Md Helal, Daniel Gibney, and Sharma V. Thankachan. "Text Indexing for Faster Gapped Pattern Matching." Algorithms 17, no. 12 (2024): 537. http://dx.doi.org/10.3390/a17120537.

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We revisit the following version of the Gapped String Indexing problem, where the goal is to preprocess a text T[1..n] to enable efficient reporting of all occ occurrences of a gapped pattern P=P1[α..β]P2 in T. An occurrence of P in T is defined as a pair (i,j) where substrings T[i..i+|P1|) and T[j..j+|P2|) match P1 and P2, respectively, with a gap j−(i+|P1|) lying within the interval [α..β]. This problem has significant applications in computational biology and text mining. A hardness result on this problem suggests that any index with polylogarithmic query time must occupy near quadratic spa
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18

Liu, Xueqing, Robert O’Connell, Alison Bendele, et al. "P153 MET642, AN ORAL FXR AGONIST, IMPROVES COLITIS INDUCED BY ADOPTIVE T-CELL TRANSFER." Inflammatory Bowel Diseases 26, Supplement_1 (2020): S6—S7. http://dx.doi.org/10.1093/ibd/zaa010.015.

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Abstract Introduction Farnesoid X receptor (FXR) is a ligand-activated nuclear hormone receptor expressed in the gastrointestinal tract, with high expression levels in the intestinal epithelium. Previously we have shown that FXR agonists with sustained activity decreased colitis in multiple chronic IBD models (i.e. Adoptive transfer colitis, Mdr1a-/- colitis, and SAMP1/YitFc ileitis). Because FXR agonists are dosed orally and do not have systemic immunosuppressive properties, they represent a novel and differentiated therapeutic approach for IBD. MET642 is an optimized, potent non-bile acid FX
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19

Buller, Ian D., Deven M. Patel, Peter J. Weyer, Anna Prizment, Rena R. Jones, and Mary H. Ward. "Ingestion of Nitrate and Nitrite and Risk of Stomach and Other Digestive System Cancers in the Iowa Women’s Health Study." International Journal of Environmental Research and Public Health 18, no. 13 (2021): 6822. http://dx.doi.org/10.3390/ijerph18136822.

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Nitrate and nitrite are precursors in the endogenous formation of N-nitroso compounds (NOC) which are potent animal carcinogens for the organs of the digestive system. We evaluated dietary intakes of nitrate and nitrite, as well as nitrate ingestion from drinking water (public drinking water supplies (PWS)), in relation to the incidence (1986–2014) of cancers of the esophagus (n = 36), stomach (n = 84), small intestine (n = 32), liver (n = 31), gallbladder (n = 66), and bile duct (n = 58) in the Iowa Women’s Health Study (42,000 women aged from 50 to 75 in 1986). Dietary nitrate and nitrite we
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20

Liu, Wen-Song, Yan Zou, Bo Yang, Yong Jiang, and Dong-lin sun. "Laparoscopic Exploration Can Salvage Recurrent Common Bile Duct Stone after Cholecystectomy." American Surgeon 83, no. 12 (2017): 1343–46. http://dx.doi.org/10.1177/000313481708301215.

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Conventionally, patients suffered from recurrent common bile duct (CBD) stone after cholecystectomy are suggested to be treated with endoscopic retrograde cholangiopancreaticography. This study was designed to explore the feasibility of laparoscopic common bile duct exploration (LCBDE) as a salvage procedure for recurrent CBD calculi after cholecystectomy. A retrospective review was conducted of data from 65 patients who underwent LCBDE for recurrent CBD calculi after cholecystectomy from January 2011 to July 2015. LCBDE was successfully carried out in 61 cases, with a successful rate of 93.8
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21

Eghtedari, Maryam, Catriona McKenzie, Lauren C. Y. Tang, Avik Majumdar, and James G. Kench. "Banff 2016 Global Assessment and Quantitative Scoring for T Cell-Mediated Liver Transplant Rejection are Interchangeable." Journal of Transplantation 2023 (March 27, 2023): 1–7. http://dx.doi.org/10.1155/2023/3103335.

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Introduction. Histopathological assessment of liver biopsies is the current “gold standard” for diagnosing graft dysfunction after liver transplantation (LT), as graft dysfunction can have nonspecific clinical presentations and inconsistent patterns of liver biochemical dysfunction. Most commonly, post-LT, graft dysfunction within the first year, is due to acute T-cell mediated rejection (TCMR) which is characterised histologically by the degree of portal inflammation (PI), bile duct damage (BDD), and venous endothelial inflammation (VEI). This study aimed to establish the relationship between
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22

Cetta, Francesco. "The Possible Role of Sphincteroplasty and Surgical Sphincterotomy in the Pathogenesis of Recurrent Common Duct Brown Stones." HPB Surgery 4, no. 4 (1991): 261–70. http://dx.doi.org/10.1155/1991/89069.

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The hypothesis has been tested that postcholecystectomy common duct stones of the brown subtype are a consequence of three factors: bile infection, old age and previous sphincterotomy. It was found that: (i) 27 of 39 consecutive patients with recurrent common duct stones had brown stones. Nineteen of these 27 patients (70.3%) had previous sphincterotomy or sphincteroplasty: (ii) six of 15 patients with stone and bile analysis both at the time of cholecystectomy and at the second operation and who had sterile operative bile and non brown stones at the first operation, formed brown stones after
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23

Shimada, Naoki, Aya Watanabe, Hiroto Ishiki, et al. "The requirement of fentanyl patch in terminally ill patients with cancer." Journal of Clinical Oncology 34, no. 26_suppl (2016): 202. http://dx.doi.org/10.1200/jco.2016.34.26_suppl.202.

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202 Background: Cancer pain is the most important problem to overcome in terminally ill cancer patients (TICPs). Recently, the fentanyl patch (FP) has been widely used for the treatment of cancer pain. However, the FP requirement largely varies in patients. The purpose of this study was to identify the determinants of the FP requirement in TICPs and propose effective pain relief using a FP. Methods: In a retrospective chart review, we investigated cancer patients who were admitted in our hospital from April 2012 to July 2015 and used FP until their deaths. We examined the time course of FP use
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24

Neverovskyi, Artem, Volodymyr Chernyavskyi, Vadim Shypulin, Lesya Gvozdecka, and Nataliya Mikhn`ova. "MODIFICATION OF GUT BACTERIAL BILE SALT HYDROLASE ACTIVITY AND CARDIOVASCULAR RISK: A RANDOMIZED STUDY." Ukrainian Scientific Medical Youth Journal 117, no. 3 (2020): 36–45. http://dx.doi.org/10.32345/usmyj.3(117).2020.36-45.

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Introduction: secretion of bacterial bile salt hydrolase (BSH) is one of the main mechanisms by which gut microbiota play role in cholesterol metabolism. There are limiting and controversial data regarding the clear effect of gut BSH activity correction on modification of serum cholesterol and cardiovascular risk (CVR). Aim of investigation was to evaluate the relationship between modification of the gut bacterial BSH relative activity (RA) by probiotic L. plantarum and serum cholesterol with CVR levels. Methods: the study was conducted as open, comparative, randomized, parallel and included 2
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Neverovskyi, Artem, Volodymyr Chernyavskyi, Vadim Shypulin, Lesya Gvozdecka, and Nataliya Mikhn`ova. "MODIFICATION OF GUT BACTERIAL BILE SALT HYDROLASE ACTIVITY AND CARDIOVASCULAR RISK: A RANDOMIZED STUDY." Ukrainian Scientific Medical Youth Journal 117, no. 3 (2020): 36–46. http://dx.doi.org/10.32345/usmyj.3(117).2020.36-46.

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Introduction: secretion of bacterial bile salt hydrolase (BSH) is one of the main mechanisms by which gut microbiota play role in cholesterol metabolism. There are limiting and controversial data regarding the clear effect of gut BSH activity correction on modification of serum cholesterol and cardiovascular risk (CVR). Aim of investigation was to evaluate the relationship between modification of the gut bacterial BSH relative activity (RA) by probiotic L. plantarum and serum cholesterol with CVR levels. Methods: the study was conducted as open, comparative, randomized, parallel and included 2
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26

Wang, Junyu, Tuantuan Gui, Tong Yin, et al. "Metabolomic Insights into the Pathogenesis and Prognostic Potential of Adult Acute Lymphoblastic Leukemia." Blood 142, Supplement 1 (2023): 2971. http://dx.doi.org/10.1182/blood-2023-184328.

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Acute lymphoblastic leukemia (ALL) comprises hematological malignancies affecting B or T cell precursors (BCP-ALL or T-ALL). Despite considerable progress made over the past three decades in the treatment of childhood ALL [5-year disease survival rate (5-y DFS): 90%], the prognosis of adult ALL remains relatively poor (5-y DFS: 50-70%). Hence, gaining a deeper understanding of the pathogenic factors is of timely importance. Recent advancements in next-generation genome sequencing technologies have facilitated the refinement of disease diagnosis and prognosis. However, due to the inherent genet
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27

Chen, Xingyu, Yinghui Song, Zhiguo Tan, et al. "Unraveling the heterogeneity of intercellular crosstalk in intrahepatic and extrahepatic cholangiocarcinoma using single-cell and spatial transcriptome profiling." JCO Global Oncology 9, Supplement_1 (2023): 50. http://dx.doi.org/10.1200/go.2023.9.supplement_1.50.

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50 Background: Extrahepatic cholangiocarcinoma (ECC) and intrahepatic cholangiocarcinoma (ICC) are two types of malignant tumors that arise from the bile duct epithelium at different locations. Currently, effective treatment options for these tumors are limited, and their microenvironmental differences remain poorly understood. Methods: We collected retrospective clinicopathological data of ECC (N=64) and ICC (N=153) patients from our hospital and integrated public database information to analyze the clinical characteristics, survival, and prognosis of ECC and ICC. We performed single-cell seq
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28

Thees, S., B. Neumaier, S. Deisenhofer, et al. "Radiation dosimetry and biodistribution of the beta-amyloid plaque imaging tracer 11C-BTA-1 in humans." Nuklearmedizin 46, no. 05 (2007): 175–80. http://dx.doi.org/10.1160/nukmed-0077.

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SummaryAim: [N-methyl-11C]2-(4'-(methylaminophenyl)-benzothiazole (11C-BTA-1) is a thioflavin-T derivative that has been one of the promising PET tracers for imaging of amyloid plaque distribution in the Alzheimer patients brain in vivo. The biodistribution and dosimetry of this tracer in humans is presented and compared to the results of a previous dosimetry and biodistribution study of another thioflavin-T derivative [N-methyl-11C]2-hydroxy-(4'-(methylaminophenyl)- benzothiazole (11C-OH-BTA-1) in baboons. Methods: Five subjects underwent 2D dynamic PET imaging. Source organs were segmented u
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29

Rahman, Md Zilanur, Mohsen Chowdhury, Bidhan C. Das, et al. "The Infectious Complications of Biliary Decompression Prior to Pancreaticoduodenectomy in a Patient with Obstructive Jaundice." Scholars Journal of Applied Medical Sciences 11, no. 03 (2023): 537–43. http://dx.doi.org/10.36347/sjams.2023.v11i03.010.

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Background: The standard of therapy for benign diseases, periampullary and ampullary cancers is pancreaticoduodenectomy (PD). These patient subgroups frequently present with obstructive jaundice, which is associated with increased morbidity due to impaired immunity and nutrition. It is controversial whether PBD should be applied routinely prior to pancreaticoduodenectomy. Objective: The purpose of this study is to investigate infectious complications of biliary decompression prior to pancreaticoduodenectomy in a patient with obstructive jaundice. Methods: This single-center, cross-sectional st
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30

Bin Anis, Saad, Pir Muneeb Rehman, Farhan Ahmad, and Umar Farooq. "Comparative Study of Conventional Electrocautery Versus Ultrasonic Dissector in Laparoscopic Cholecystectomy." Journal of Islamabad Medical & Dental College 8, no. 2 (2019): 70–73. http://dx.doi.org/10.35787/jimdc.v8i2.358.

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Background: Laparoscopic cholecystectomy (LC) is very commonly performed for removal of gallstones. In routine, ultrasonic devices are used for laparoscopy involving the deeper operating fields, while electrosurgical devices are preferred for LC. However, nowadays both of these devices are used for LC. The objective of this study was to compare the surgical outcomes of ultrasonic dissector over conventional electrocautery in patients planned for LC. Material and Methods: This non-randomized clinical trial was conducted in general surgery unit, Jinnah hospital Lahore. The study duration was 15t
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31

Zhou, Yong, Guo-qin Jiang, Ren-Gen Fan, Wen-Zhang Zha, and Xu-dong Wu. "Left liver anatomical resection via the left vertical groove and intraoperative antegrade cholangioscopy in patients with left-sided hepatolithiasis and previous biliary tract surgery." Journal of International Medical Research 47, no. 10 (2019): 4872–77. http://dx.doi.org/10.1177/0300060519864832.

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Objective This study aimed to assess the safety and efficacy of left liver anatomical resection via the left vertical groove following intraoperative antegrade cholangioscopy (biliary exploration through the left hepatic duct orifice) in patients with left-sided hepatolithiasis (LSH) and previous biliary tract surgery. Methods Between January 2012 and January 2016, eligible patients with LSH (n = 28) who underwent left liver anatomical resection via the left vertical groove followed by intraoperative antegrade cholangioscopy, were referred to our hospital. Clinical results, such as the overall
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32

Mustafa, Başaran, and Kaya Mehmet. "Eski Türk Eserlerinde "Saygı"." Ahlak Dergisi 1, no. 2 (2021): 1–16. https://doi.org/10.5281/zenodo.5336912.

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Doğası gereği toplumsal bir varlık olarak yaşayan insan, &ccedil;evresiyle ilişkilerinde saygılı olmak zorundadır. Saygı kişiler arası iletişimin en temel &ouml;ğelerinden birisidir. Sadece insanlara g&ouml;sterilmesi gereken bir tutum olmamakla birlikte doğadaki b&uuml;t&uuml;n varlıklar i&ccedil;in &ccedil;ok değerlidir. Buradan hareketle bu &ccedil;alışmanın konusu saygı olarak belirlenmiş ve saygı kavramının, k&uuml;lt&uuml;r&uuml;m&uuml;z&uuml;n &ouml;ğelerinin sık&ccedil;a yer bulduğu, T&uuml;rk k&uuml;lt&uuml;r&uuml;n&uuml;n &ouml;nemli &uuml;&ccedil; eseri olan Kutadgu Bilig, Dedem Kor
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33

Koyama, Daisuke, Masafumi Ito, Sonoko Kamoshita, et al. "Autoimmune-Like Hepatitis Following Allogeneic Hematopietic Stem Cell Transplantation: Different Manifestation From Hepatic Graft-Versus-Host Disease." Blood 118, no. 21 (2011): 4550. http://dx.doi.org/10.1182/blood.v118.21.4550.4550.

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Abstract Abstract 4550 Background: Occasional cases of post-transplant liver dysfunction which resemble autoimmune hepatitis have been reported. Although pathologically indistinguishable from ‘definite’ autoimmune hepatitis, they occur with an alloimmune etiology because the liver is of recipient origin while the immune system is of donor origin (therefore, it is autoimmune “like” hepatitis (AILH) precisely). However, the incidence and clinical features of autoimmune-like hepatitis following allogeneic stem cell transplantation (allo-HSCT) are hitherto unknown. Therefore, the aim of this study
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34

Maimonis, Peter J., Yoh Zen, David J. Britton, et al. "Identification of new liver tumor biomarkers using proteomics." Journal of Clinical Oncology 30, no. 15_suppl (2012): e21091-e21091. http://dx.doi.org/10.1200/jco.2012.30.15_suppl.e21091.

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e21091 Background: It is crucial to identify new biomarkers that help diagnose cancers at an early stage and contribute to the development of new anti-cancer drugs. Here, we identify new liver tumor biomarkers using proteomics. Methods: We evaluated 9 types of liver tissue from 55 patients: normal liver parenchyma (n=7), hepatocellular carcinoma (HCC) (n=7), normal bile duct (n=6), peripheral cholangiocarcinoma (CC) (n=7), hilar CC (n=7), CC associated with primary sclerosing cholangitis (PSC) (n=7), metastatic colorectal cancer (n=7), and mixed HCC/CC after trans-arterial chemoembolization (n
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35

Haslam, Danielle E., Jun Li, Liming Liang, et al. "Changes in Metabolites During an Oral Glucose Tolerance Test in Early and Mid-Pregnancy: Findings from the PEARLS Randomized, Controlled Lifestyle Trial." Metabolites 10, no. 7 (2020): 284. http://dx.doi.org/10.3390/metabo10070284.

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The oral glucose tolerance test (OGTT) is used to diagnose gestational and other types of diabetes. We examined metabolite changes during an OGTT, and how a comprehensive diet and physical activity intervention may influence these changes in a population of overweight/obese Hispanic pregnant women. Integration of changes in metabolites during an OGTT may help us gain preliminary insights into how glucose metabolism changes during pregnancy. Among women from the Pregnancy and EARly Lifestyle improvement Study (PEARLS), we measured metabolites during a multipoint OGTT (fasting, 30, 60 and 120 mi
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36

Chu, F., and C. Hailong. "DOP021 Appendectomy regulates intestinal flora-bile acid axis inhibits macrophage lipid metabolism and improves Ulcerative Colitis." Journal of Crohn's and Colitis 19, Supplement_1 (2025): i126—i127. https://doi.org/10.1093/ecco-jcc/jjae190.0060.

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Abstract Background The specific role of the appendix as both an immune organ and a reservoir for gut microbiota in inflammatory bowel disease (IBD) remains elusive. Recent clinical studies have demonstrated that appendectomy can alleviate refractory ulcerative colitis and reduce the rate of colon surgical resection in patients. However, the underlying mechanisms are still unclear. This study aims to comprehensively explore the precise regulatory mechanisms of appendectomy in the process of colonic inflammation. Methods Appendectomy was performed on C57BL/6 mice followed by induction of dextra
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Zhong, Hua, and Jian-Ping Gong. "Mirizzi Syndrome: Experience in Diagnosis and Treatment of 25 Cases." American Surgeon 78, no. 1 (2012): 61–65. http://dx.doi.org/10.1177/000313481207800136.

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The objective of this study is to summarize the experience in diagnosis and treatment of Mirizzi syndrome (MS) and reduce the incidence of operative complications. Twenty-five cases of Mirizzi syndrome from January 2005 to January 2010 were retrospectively analyzed. There were 11 male patients and 14 female patients, ranging in ages from 26 to 80 years with a median age of 51.3. Preoperative radiological diagnosis was achieved in 10 patients: ultrasonography (n = 5) and magnetic resonance cholangiopancreatography (n = 10). The others were diagnosed intra-operatively. Fifteen patients had Type
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38

Iwata, Rika, Katharina Baur, Bruno Stieger, et al. "A common polymorphism in the ABCB11 gene is associated with advanced fibrosis in hepatitis C but not in non-alcoholic fatty liver disease." Clinical Science 120, no. 7 (2010): 287–96. http://dx.doi.org/10.1042/cs20100246.

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Chronic HCV (hepatitis C virus)-associated cirrhosis represents a major indication for liver transplantation. Bile acids contribute to hepatic stellate cell activation as a key event in fibrogenesis. The aim of the present study was to investigate the role of bile acids and polymorphisms in bile acid level-regulating genes on fibrosis progression. A total of 206 subjects with chronic HCV infection were included for ABCB11 (ATP-binding cassette, subfamily B, member II) 1331T&gt;C and NR1H4 (nuclear receptor) −1G&gt;T genotyping, 178 of which were analysed for fibrosis stage. Exclusion criteria
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39

Nikander, Sven. "On the anatomy and topography of the pancreas and the pancreatic duct in reindeer {Rangifer tarandus tarandus L)." Rangifer 10, no. 1 (1990): 25. http://dx.doi.org/10.7557/2.10.1.787.

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&lt;p&gt;The complex development of the pancreas accounts for the differences in its morphology among various animal species. According to the present study, the anatomy of the pancreas in the reindeer is quite similar to that in small ruminants. It consists of two lobes, the left one (tail) extending in a ventrodorsal direction is in contact with the rumen, spleen, and the left adrenal gland. The right lobe (head) lies within the curve of the duodenum. Ducts analogous to the &lt;em&gt;ductus pancreaticus major&lt;/em&gt; (Wirsungi) and &lt;em&gt;minor&lt;/em&gt; (Santorini) join in a common p
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40

Göçmen, Akif. "İbn Kayyim el-Cevziyye'nin Tahrîf Anlayışı (Ibn Qayyim al-Jawziyya's Understanding of Taḥrīf)". Oksident: Yahudilik, Hıristiyanlık ve Batı Araştırmaları Dergisi - Journal for the Study on Judaism, Christianity and the West in Turkey 5, № 1 (2023): 61–100. https://doi.org/10.51490/oksident.1259913.

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&nbsp; &Ouml;zet İbn Kayyim el-Cevziyye yazdığı eserleri ve g&ouml;r&uuml;şleriyle dikkat &ccedil;eken M&uuml;sl&uuml;man &acirc;limlerden biridir. Onun Yahudilere ve Hıristiyanlara karşı yazdığı <em>Hid&acirc;yet&uuml;&rsquo;l-Hay&acirc;r&acirc; f&icirc; Ecvibeti&rsquo;l-Yeh&ucirc;d ve&rsquo;n-Nas&acirc;r&acirc;</em> adlı reddiyesi Yahudi ve Hıristiyan kutsal metinlerinin tahr&icirc;fini ve diğer bazı Dinler Tarihi meselelerini ayrıntılı olarak incelemesi sebebiyle m&uuml;him bir eserdir. İbn Kayyim hakkında pek &ccedil;ok akademik &ccedil;alışma yapılmıştır; ancak ulusal literat&uuml;rde onu
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41

Wildenboer, Johan. "JOSHUA 24: SOME LITERARY AND THEOLOGICAL REMARKS." Journal for Semitics 24, no. 2 (2017): 484–502. http://dx.doi.org/10.25159/1013-8471/3465.

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Achenbach, R 2005. Pentateuch, Hexateuch und Enneateuch. Eine Verhältnisbestimmung, ZAR 11:122–154. Albertz, R 2007. Die kanonische Anpassung des Johuabuches. Ein Neubewertung seiner sog.”Priesterschriftelike Texte”, in Römer and Schmid 2007:199–217. Aurelius, E 2003. Zukunft jenseits des Gerichts: Eine redaktionsgeschichltliche Studie zumEnneateuch. BZAW 319. Berlin: de Gruyter. Barrick, W B &amp; Spencer, J R (eds) 1984. In the shelter of Elyon: essays on ancient Palestinian life in honour of GW Ahlström. JSOTSup 31. Sheffield: JSOT Press. Becker U, 2006. Endredaktionelle Kontextvernetzungen
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42

Farhat, Zeinab, Neal D. Freedman, Joshua N. Sampson, et al. "Abstract 2385: A prospective investigation of serum bile acids with risk of liver cancer, fatal liver disease, and biliary cancer." Cancer Research 82, no. 12_Supplement (2022): 2385. http://dx.doi.org/10.1158/1538-7445.am2022-2385.

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Abstract Abstract Background: Laboratory and emerging epidemiologic data suggest that bile acids (BAs), major regulators of the gut microbiota, play an important role in liver disease and cancer etiology. However, few epidemiologic studies have comprehensively examined associations between BAs and either liver endpoints or biliary cancer. Methods: In the Alpha-Tocopherol, Beta-Carotene Cancer Prevention (ATBC) Study, we designed 1:1 matched nested case-control studies of primary liver cancer (n=247 cases), fatal liver disease (n=261 cases), and primary biliary cancer (n=92 cases). Using baseli
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43

Ussov, W. Yu, M. L. Belyanin, O. Y. Borodin, A. I. Bezlepkin, A. A. Churin, and N. L. Shimanovsky. "Preclinical Study of the Imaging Properties of the Mn(Ii)–D-Myo-Inositol-1, 2, 3, 4, 5, 6- Hexakisdihydrophosphoric Acid Complex as a Hepatospecific Paramagnetic Contrast Agent." MEDICAL RADIOLOGY AND RADIATION SAFETY 69, no. 6 (2024): 56–63. https://doi.org/10.33266/1024-6177-2024-69-6-56-63.

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Purpose: We tried to create a hepatospecific paramagnetic contrast agent – a paramagnetic analogue of 99mTc-technefit, by obtaining a paramagnetic Mn(II) complex with phytic (D-myo-inositol-1, 2, 3, 4, 5, 6– hexakisdihydrophosphoric) acid. Material and methods: A hepatotropic magnetic resonance contrast compound was obtained as an aqueous solution containing a paramagnetic Mn(II) complex with D-myo-inositol-1, 2, 3, 4, 5, 6-hexakis dihydrophosphoric (phytic) acid in a concentration of 0.5 M, with the addition of a 0.5M aqueous solution of meglumine (N-methylglucamine) in a ratio of 1:4 by volu
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44

Pandit, Narendra, Laligen Awale, Tek Narayan Yadav, Kunal Bikram Deo, and Shailesh Adhikary. "Treatment outcome of hepatolithiasis: Nepalese experience." International Surgery Journal 7, no. 4 (2020): 994. http://dx.doi.org/10.18203/2349-2902.isj20201378.

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Background: Hepatolithiasis is a rare disease with high rate of treatment failure and recurrence. This study aims to review the burden, management and outcome from an endemic region.Methods: A retrospective review of database of patients with hepatolithiasis managed surgically from 2015 to 2019 was performed. Diagnosis was based on the clinical findings and radiological investigations. Demographic data, clinical presentation, extent of disease and type of surgical management were evaluated. The outcome measures included immediate stone clearance, postoperative complications and follow-up.Resul
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45

Yang, Renchi, Hu Zhou, Yu Hu, et al. "Safety, Pharmacokinetics and Preliminary Efficacy of HMPL-523 in Adult Patients with Primary Immune Thrombocytopenia: A Randomized, Double-Blind and Placebo-Controlled Phase 1b Study." Blood 138, Supplement 1 (2021): 16. http://dx.doi.org/10.1182/blood-2021-149895.

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Abstract Background: Primary immune thrombocytopenia (ITP) is characterized by increased platelet destruction and impaired platelet production, resulting in decreased platelet counts and increased bleeding risk. Spleen Tyrosine Kinase (Syk) plays a pivotal role in the regulation of downstream signals in immune receptors, including B cell receptors (BCRs) and has been implicated in autoantibody production. On the other hand, all activating Fc receptors signal via Syk, which has roles in cellular proliferation, differentiation, survival, immune regulation, and cytoskeletal rearrangements during
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46

Nankar, Meenakshi, Hrishikesh Walimbe, Mohammed Nadeem Ahmed Bijle, Sneha Muchandi, Srishti Chaturvedi, and Priyanka Karekar. "Comparative Evaluation and Correlation of Salivary Total Antioxidant Capacity and Salivary pH in Caries-free and Severe Early Childhood Caries Children." Journal of Contemporary Dental Practice 16, no. 3 (2015): 234–37. http://dx.doi.org/10.5005/jp-journals-10024-1667.

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ABSTRACT Background Dental caries is a major problem in preschool children. The contribution of saliva in providing defense during caries process is of primary importance. pH buffer capacity through bicarbonate, phosphate and protein buffer systems have universal acceptance as a caries defense mechanism. Antioxidant capacity of saliva can constitute a first line of defense against chronic degenerative diseases including dental caries. Till date, no study is presented with salivary antioxidant capacity of younger children affected with severe early childhood caries with its salivary pH correlat
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47

Kanikovskyi, O. Y., Y. V. Karyi, I. P. Dovgan, I. L. Chereshniuk, and O. V. Shypitsyna. "Characterization of morphological disorders of the liver depending on the bilirubin count in patients with obstructive jaundice." Reports of Vinnytsia National Medical University 28, no. 3 (2024): 379–82. http://dx.doi.org/10.31393/reports-vnmedical-2024-28(3)-02.

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Annotation. According to WHO, obstructive jaundice (OJ) is observed in 10-15% of the world's population. The choice of bile duct decompression technique and timing depends not only on the duration of OJ and also on the bilirubin count in the blood. The study of morphological disorders of the liver in cases of various bilirubin count in patients with OJ, will prevent post-decompression liver dysfunction and the development of biliary cirrhosis. The aim – to study morphological disorders of the liver depending on the bilirubin count in patients with obstructive jaundice. 30 OJ patients were subd
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48

Zhu, Renwei, Sha Tan, Yayi Wang, Linwei Zhang, and Liang Huang. "Physicochemical Properties and Hypolipidemic Activity of Dietary Fiber from Rice Bran Meal Obtained by Three Oil-Production Methods." Foods 12, no. 19 (2023): 3695. http://dx.doi.org/10.3390/foods12193695.

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This study investigated the effects of three oil production methods on the physicochemical properties of dietary fiber from rice bran flour, and the hypolipidemic effects of the dietary fibers were investigated in vitro and in vivo. The particle size results showed that the organic-solvent-impregnated rice bran meal dietary fiber (N-RBDF) had the smallest average particle size and the aqueous enzymatic rice bran meal dietary fiber (E-RBDF) had the narrowest particle size distribution. Scanning electron microscopy (SEM) results demonstrated that all three kinds of rice bran meal dietary fibers
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49

Sekaran, P., AR Ross, A. Rooney, et al. "Introduction of paediatric laparoscopic cholecystectomy in Scotland: a national review of incidence, outcomes and training implications." Scottish Medical Journal 66, no. 3 (2021): 148–51. http://dx.doi.org/10.1177/0036933021995958.

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Background We present a national data series to determine the incidence, outcomes and training opportunities for laparoscopic cholecystectomy among children &lt;16yrs in Scotland as performed by paediatric surgeons. Methods A retrospective cohort study was performed reviewing laparoscopic cholecystectomy performed at the three children’s hospitals in Scotland. Using the National Records Scotland Database mid-year population estimates; age and sex specific annual incidence rates of laparoscopic cholecystectomy were calculated between 1998-2015. Trends in the observed case mix were tested using
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50

Tan, Ker-Kan, Vishalkumar Girishchandra Shelat, Kui-Hin Liau, Chung-Yip Chan, and Choon-Kiat Ho. "Laparoscopic Common Bile Duct Exploration: Our First 50 Cases." Annals of the Academy of Medicine, Singapore 39, no. 2 (2010): 136–42. http://dx.doi.org/10.47102/annals-acadmedsg.v39n2p136.

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Introduction: Laparoscopic common bile duct exploration (CBDE) is becoming more popular in the management of choledocholithiasis due to improved laparoscopic expertise and advancement in endoscopic technology and equipment. This study aimed to evaluate the safety and short-term outcome of laparoscopic CBDE in a single institution over a 3-year period. Materials and Methods: A retrospective review of the records of all patients who underwent laparoscopic CBDE in Tan Tock Seng Hospital between January 2006 and September 2008 was conducted. Results: Fifty consecutive patients, with a median age o
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