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Chung, Jo-Lan. "Identifying protein-protein binding sites and binding partners using sequence and structure information /". Diss., Connect to a 24 p. preview or request complete full text in PDF formate. Access restricted to UC campuses, 2007. http://wwwlib.umi.com/cr/ucsd/fullcit?p3244170.
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Foo, Chia Mun. "Learning Requires Attention for Binding Affective Reinforcement to Information Content". Scholarship @ Claremont, 2015. http://scholarship.claremont.edu/scripps_theses/555.
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Humans are limited in their capacity to process information about the environment; to choose the most salient details to process, we have to make rapid value appraisals and prioritize our attentional resources. In this proposed study, it is expected that attention is required to learn from affective information. Learning is measured by the difference between update (the difference between the first and second estimation) and the estimation error (the difference between the average likelihood and the first estimation). Using a belief-updating paradigm, participants will be asked to estimate their likelihood of encountering a negative event, once before and once after they receive the average likelihood information. By comparing the difference in estimations after being exposed to desirable or undesirable information and a positive or negative reinforcer across three levels of attentional load, the effects of attention on learning from affective reinforcement can be examined. It is proposed that attention mediates learning from affective information. This is demonstrated by the failure to learn differentially from affective information under high attentional load, while in a no load condition participants will learn differentially according to the type of news and affective reinforcer that they receive. The expected result would indicate that attention is a necessity for optimal learning outcomes, especially when learning from affective information. This has implications in the effectiveness of communicating affective information, such as in the health care field.
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Johnson, Cotteka Nichisha. "Characterization of the DNA-binding properties of silent information regulator 3 protein". Huntington, WV : [Marshall University Libraries], 2006. http://www.marshall.edu/etd/descript.asp?ref=691.
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Luo, Tong. "Towards Simpler Argument Binding : Knowledge Gathering by Mining Logic Program Repositories". Thesis, Uppsala universitet, Institutionen för informatik och media, 2016. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-296131.
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The compositional relational programming (CRP) is a purely declarative and naturally compositional programming paradigm, but the low readability and some binding issues limit its use. The main purpose in this thesis is utilizing the common binding patterns identified from Prolog programs to improve current argument binding mechanism in CRP. In order to collect relevant Prolog rules and convert them to a measurable form, a data mining tool is built and applied to extract data from Prolog code repository. After the analysis, two kinds of patterns are identified respectively, based on the binding outside and inside the logical combination. Correspondingly, the projection operator make is optimized for highlighting the dummy argument; three extended and combinators are proposed to handle common binary combinations; the join operator is modified to efficiently and flexibly combine multiple predicates. In the future, the usability of those improved operators should be carefully evaluated.
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Rodríguez, Mario Alfredo Parra. "Binding information in short-term memory : evidence from healthy individuals, Alzheimer's Disease and other clinical populations". Thesis, University of Edinburgh, 2009. http://hdl.handle.net/1842/3440.
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Memory binding is a cognitive process that enables complex objects to be stored or retrieved coherently during perception, learning, or action. Binding functions are aimed at reducing the misattribution of the features of objects in crowded and changing sensory contexts, ensuring accurate representation in visual working memory. Binding is a relatively new concept in working memory research. However, as an integrative function it provides a rich context in which to investigate the mechanisms underlying memory deterioration. In this PhD project, a range of experimental temporary binding paradigms were used to investigate whether some of the memory impairments observed in patients with Alzheimer’s Disease could be accounted for by deficits in this memory function. A set of neuropsychological tasks were used to investigate binding operations across memory domains (i.e., verbal and nonverbal), sensory modalities (i.e., visual and auditory), types of information (e.g., objects and colours), and retrieval processes (i.e., recognition and recall) in healthy individuals, Alzheimer’s Disease patients and other clinical populations. The results suggest that the efficiency of short-term memory to store bound complex events depends on the nature of the information presented (e.g., type of information bound into objects) (Chapter 2). Short-term memory seems to be equipped with relatively separate mechanisms to store integrated objects and individual features (Chapter 4). It was also observed that the binding properties of short-term memory apply to healthy young and older people, and are functions which are preserved in the elderly (Chapter 3). In two additional experimental chapters (5 and 6) the preserved binding abilities of older people were compared with temporary binding in Alzheimer’s Disease. The latter group showed a very large impairment in binding that was distinct from their impairments in memory for individual features. These findings suggest that memory binding tasks could reliably separate the cognitive changes in normal ageing from those linked with Alzheimer’ Disease. Moreover, the results of Chapter 7 suggested that memory binding tasks may detect memory changes in people that will develop Alzheimer’ Disease (i.e., asymptomatic carriers of the gene defect E280A of the Preseniline-1 gene) almost 10 years before the average age of onset. These results are relevant to our understanding of short-term memory and to the memory models currently available. Finally, it is suggested that the constructs of memory binding may increase the sensitivity of current assessment procedures for people at risk of developing Alzheimer’s Disease.
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Samuel, Jarvie John. "Elicitation of Protein-Protein Interactions from Biomedical Literature Using Association Rule Discovery". Thesis, University of North Texas, 2010. https://digital.library.unt.edu/ark:/67531/metadc30508/.
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Extracting information from a stack of data is a tedious task and the scenario is no different in proteomics. Volumes of research papers are published about study of various proteins in several species, their interactions with other proteins and identification of protein(s) as possible biomarker in causing diseases. It is a challenging task for biologists to keep track of these developments manually by reading through the literatures. Several tools have been developed by computer linguists to assist identification, extraction and hypotheses generation of proteins and protein-protein interactions from biomedical publications and protein databases. However, they are confronted with the challenges of term variation, term ambiguity, access only to abstracts and inconsistencies in time-consuming manual curation of protein and protein-protein interaction repositories. This work attempts to attenuate the challenges by extracting protein-protein interactions in humans and elicit possible interactions using associative rule mining on full text, abstracts and captions from figures available from publicly available biomedical literature databases. Two such databases are used in our study: Directory of Open Access Journals (DOAJ) and PubMed Central (PMC). A corpus is built using articles based on search terms. A dataset of more than 38,000 protein-protein interactions from the Human Protein Reference Database (HPRD) is cross-referenced to validate discovered interactive pairs. A set of an optimal size of possible binary protein-protein interactions is generated to be made available for clinician or biological validation. A significant change in the number of new associations was found by altering the thresholds for support and confidence metrics. This study narrows down the limitations for biologists in keeping pace with discovery of protein-protein interactions via manually reading the literature and their needs to validate each and every possible interaction.
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Olsson, H. A. Joakim. "An evaluation of the Integrated Information Theory against some central problems of consciousness". Thesis, Högskolan i Skövde, Institutionen för biovetenskap, 2015. http://urn.kb.se/resolve?urn=urn:nbn:se:his:diva-11659.
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This thesis evaluates the integrated information theory (IIT) by looking at how it may answer some central problems of consciousness that the author thinks any theory of consciousness should be able to explain. The problems concerned are the mind-body problem, the hard problem, the explanatory gap, the binding problem, and the problem of objectively detecting consciousness. The IIT is a computational theory of consciousness thought to explain the rise of consciousness. First the mongrel term consciousness is defined to give a clear idea of what is meant by consciousness in this thesis; followed by a presentation of the IIT, its origin, main ideas, and some implications of the theory. Thereafter the problems of consciousness will be presented, and the explanation the IIT gives will be investigated. In the discussion, some not perviously—in the thesis—discussed issues regarding the theory will be lifted. The author finds the IIT to hold explanations to each of the problems discussed. Whether the explanations are satisfying is questionable.
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Lu, Daming. "A Combined Motif Discovery Method". ScholarWorks@UNO, 2009. http://scholarworks.uno.edu/td/990.
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A central problem in the bioinformatics is to find the binding sites for regulatory motifs. This is a challenging problem that leads us to a platform to apply a variety of data mining methods. In the efforts described here, a combined motif discovery method that uses mutual information and Gibbs sampling was developed. A new scoring schema was introduced with mutual information and joint information content involved. Simulated tempering was embedded into classic Gibbs sampling to avoid local optima. This method was applied to the 18 pieces DNA sequences containing CRP binding sites validated by Stormo and the results were compared with Bioprospector. Based on the results, the new scoring schema can get over the defect that the basic model PWM only contains single positioin information. Simulated tempering proved to be an adaptive adjustment of the search strategy and showed a much increased resistance to local optima.
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Völzmann, André [Verfasser]. "The homeodomain of the Drosophila Ceramide Synthase Schlank confers nuclear import information and DNA binding capabilities / André Völzmann". Bonn : Universitäts- und Landesbibliothek Bonn, 2014. http://d-nb.info/1077289820/34.
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Orenäs, Nissas Sebastian y Nangi Rahimi. "Digitalized Construction Project : To Build after a Legally Binding BIM-model". Thesis, KTH, Fastigheter och byggande, 2020. http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-279110.
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Digitalization has become something of a buzzword in today's society and rightly so as it brings multiple benefits and opportunities. The AEC/FM industry has constantly lagged behind other industries in terms of change and development and is often regarded as conservative. Strongly associated with digitalization in construction are the concepts of Building Information Modeling (BIM) and Virtual Design and Construction (VDC), which partly include technology and models for integrated and model-based approaches to, for example, reduce fragmentation between project members who traditionally work independently of one another. In research, it is revealed that there are large gains with a successful implementation of BIM/VDC in projects and this is something that many companies in the industry are working with and seeking to develop. The purpose of the thesis is to investigate how the project team members have worked and how the working methods are perceived by them in a well-known construction project in Sweden, where they have taken a step further in digitalizing construction by building after a legally binding digital model instead of the traditional paper drawings. The subject is explored with a qualitative method, in the form of a case study, where a scientific literature study, interview study, and observations together form the basis of the study and these parts act as a basis for the discussion. The literature study covers previous research as well as concepts relevant for answering formulated research questions and concepts that emerged during the interview study that are important to understand for a qualitative discussion and, consequently, qualitative conclusions. In the interview study, 13 respondents were interviewed in so-called semi-structured interviews and all of them were involved in the case project. The findings indicate that the BIM-model can contribute to better communication, higher resource efficiency, better quality and, at the same time for a lower total cost of the project. Identified perceptions in designing a BIM-model and then building after the model instead of 2D drawings are predominantly positive. While advantages and opportunities are demonstrated by this way of working, new challenges and risks arise. This entails legal risks, technical risks and management risks. There are new types of errors that arise with a more detailed design.Digitalisering har blivit något av ett modeord inom dagens samhälle och det med all rätt då det medför sina fördelar och möjligheter. Bygg- och fastighetsbranschen har ständigt släpat efter övriga industrier vad gäller förändring och utveckling och ses därefter ofta som konservativ. Starkt associerat med digitalisering inom bygg är koncepten Building Information Modeling (BIM) och Virtual Design and Construction (VDC) som dels innefattar teknologi och modeller för integrerade och modellbaserade arbetssätt. De används exempelvis för att minska fragmentering mellan projektmedlemmar som vanligen enbart fokuserar på sina egna teknikområden. Inom forskningsvärlden sägs det finnas stora vinningar med en lyckad implementering av BIM/VDC i projekt och det är något som många företag inom branschen arbetar med och söker utveckla. Samtidigt anger forskningen också att det finns stora utmaningar och att man ännu inte kommit så långt med digitaliseringen. Syftet med detta examensarbete är bland annat att undersöka hur projektmedlemmar har arbetat och hur arbetssätten har upplevts i ett av få välkända byggprojekt i Sverige där man tagit ett steg längre i att digitalisera byggandet genom att bygga efter en digital modell som juridisk bygghandling istället för de traditionella pappersritningarna. Ämnet utforskas kvalitativt, i form av en fallstudie, där en vetenskaplig litteraturstudie, intervjustudie samt observationer tillsammans utgör grunden för arbetet och som alla agerar underlag för analysdelen. Litteraturstudien täcker tidigare studier på området för att beskriva kunskapsläget samt koncept som är relevanta för att besvara formulerade frågeställningar samt begrepp som dykt upp under intervjustudien som är viktiga att förstå för en kvalitativ diskussion och följaktligen likaså kvalitativa slutsatser. I intervjustudien har 13 respondenter intervjuats i så kallade semi-strukturerade intervjuer och som alla varit inblandade i det undersökta projektet. Resultatet tyder på att BIM-modellen kan bidra till en bättre kommunikation, högre resurseffektivitet, bättre kvalitet och samtidigt till en lägre totalkostnad av projektet. Identifierade upplevelser med att projektera en BIM-modell och att därefter bygga efter modellen istället för 2Dritningar är till övervägande del positiva. Samtidigt som fördelar och möjligheter påvisas med detta arbetssätt så uppkommer nya utmaningar och risker. Det medför juridiska risker, tekniska risker och hanteringsrisker. Det är exempelvis nya typer av fel som uppkommer med en mer detaljerad projektering.
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Olsheski, Julia DeBlasio. "The role of synesthetic correspondence in intersensory binding: investigating an unrecognized confound in multimodal perception research". Diss., Georgia Institute of Technology, 2013. http://hdl.handle.net/1853/50215.
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The current program of research tests the following main hypotheses: 1) Synesthetic correspondence is an amodal property that serves to bind intersensory signals and manipulating this correspondence between pairs of audiovisual signals will affect performance on a temporal order judgment (TOJ) task; 2) Manipulating emphasis during a TOJ task from spatial to temporal aspects will strengthen the influence of task-irrelevant auditory signals; 3) The degree of dimensional overlap between audiovisual pairs will moderate the effect of synesthetic correspondence on the TOJ task; and 4) There are gaps in current perceptual theory due to the fact that synesthetic correspondence is a potential confound that has not been sufficiently considered in the design of perception research. The results support these main hypotheses. Finally, potential applications for the findings presented here are discussed.
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Näzell, Oscar. "Uppdatering av stora interaktiva börstabeller med two-way data binding och virtual dom : En jämförelse av prestanda mellan kärntekniker i AngularJS och React". Thesis, Högskolan i Skövde, Institutionen för informationsteknologi, 2020. http://urn.kb.se/resolve?urn=urn:nbn:se:his:diva-18702.
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Målet med studien var att undersöka hur tidseffektivt JavaScript ramverket AngularJS och biblioteket React uppdaterar interaktiva börsdatatabeller. Undersökningen är inspirerad av tidigare forskning från Högskolan i Skövde fast med ett fokus på större tabellstorlekar. För att utvärdera prestandan upprättades ett kontrollerat experiment där två applikationer per ramverk/bibliotek skapades för att både jämföra skillnader mellan AngularJS och React men även för att undersöka hur olika designval inom ett ramverk/bibliotek påverkar resultatet. Till applikationerna applicerades sex tabeller med olika rad- och kolumnantal och i varje tabell var det möjligt att både sortera och filtrera innehållet. Resultaten visade att React var snabbare oavsett tabellstorlek och interaktionstyp. Vid sortering fanns det även signifikanta skillnader mellan varianterna inom samma ramverk/bibliotek, främst för AngularJS. Potentiell vidareutveckling av arbetet kan exempelvis inkludera fler aktuella ramverk eller utvärdera mot användare i en fallstudie för att undersöka om skillnaderna upplevs av en användare.
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Kattan, Shahad. "The regulation of chromatin and transmission of epigenetic information by the heterochromatin protein 1, binding protein 3 (HP1BP3) in normal and colorectal cancer cells". Thesis, University of Nottingham, 2017. http://eprints.nottingham.ac.uk/41804/.
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The heterochromatin-associated proteins are subject to several different posttranslational modifications; hence, their level must be tightly controlled; otherwise as transcription factor co-repressor(s) complexes with these proteins, it may lead to stable silencing. An obvious mechanism to limit the expression time of a protein is to destroy it via the ubiquitin-proteasome system. FBXW7 (F-box and WD repeat domain–containing 7) is an E3-ligase targets transcriptional modulators and proto-oncogenes for degradation with crucial functions in cell-fate determination and tumorigenesis. In addition, most of current studies focused on epigenetic modifications that influence on the core histones within the euchromatin-heterochromatin transition, whereas the heterochromatin proteins and their partners’ identity remained largely unclear. Dr Nateri’s lab have recently identified several proteins which are targeted by the FBXW7 E3 ligase for the ubiquitin-mediated degradation. Among others, my study was focused on the role(s) of heterochromatin protein– binding protein 3 (HP1BP3) protein in epigenetic-reprogramming and its underlining mechanisms, including EMT and cell cycle progression, in normal and cancer cells. It's worth mentioning that apart from the single publication (Hayashihara et al., 2010a), the role of HP1BP3 was unknown when I began my project. HP1BP3 modulates the entry/exit of nucleosomal-DNA through binding to HP1α protein. HP1α is enriched in the pericentromeric heterochromatin, and it has been reported that HP1α recruitment in this region depends on SUV39H1/2-mediated H3K9 trimethylation. Widespread epigenomic alterations, occurs during cell differentiation, cell cycle progression and malignant transformation, but how epigenetic mechanisms contribute to the transcriptional reprogramming that accompanies EMT is still poorly understood. Furthermore, chromatin modulation events are important to control the cell-cycle-dependant gene expression during development and differentiation. Dysregulated expression of upstream cell-cycle regulators can affect DNA replication, repair, and/or division, leading to carcinogenic. Herein, our data show that the loss of FBXW7 mediated HP1BP3 induction alters heterochromatin states, through rescuing HP1α from its repressive function, impairing SUV39H1-mediated the methylation of histone H3 lysine 9 (H3K9me3), and stimulating the acetylation of H3K9 (H3K9ac) that lead to activation of epithelial-mesenchymal transition (EMT) pathway in Tiger skin fibroblast and HCT116 human colorectal cell lines. This induction of HP1BP3 upregulates the level of mesenchymal markers/regulators (Ncadherin, ZEB-1, Vimentin, and Snail1) in Tiger fibroblast cells while downregulating the epithelial marker (E-cadherin) and upregulating mesenchymal markers (ZEB-1, Vimentin, and Snail1) in HCT116 cells. In addition, upregulated HP1BP3 is an inducer of both G2/M cell cycle arrest and G1 to S phase transition via downregulating Cyclin B1 and SUV39H1/H3K9me3 while upregulating H3K9ac mark, in human Tiger fibroblasts and HCT116 CRC cells. Taken together, these findings point towards the important biological functions of HP1BP3 and its contribution in regulation of chromatin/EMT associated genes expression which consequently can be implicated in the pathogenesis of different types of FBXW7-mutated cancer.
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Godoy, Juliana Pardo Moura Campos. "Integração de informações visuais e verbais na memória de trabalho". Universidade de São Paulo, 2010. http://www.teses.usp.br/teses/disponiveis/59/59134/tde-18032010-134348/.
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O paradigma de tarefas duplas foi utilizado para investigar o envolvimento da atenção na conjunção da informação verbal e visual na memória de trabalho, e o papel específico desses componentes quando integrados. Em dois experimentos os sujeitos (33) memorizaram seqüências de Faces, Nomes, ou Conjunções face-nome. No experimento 1 essas condições foram realizadas, em blocos separados, isoladamente ou junto com uma contagem regressiva de três em três (CR3). No experimento 2 essas condições foram realizadas, em blocos separados, com uma supressão articulatória (SA) e com um ruído visual dinâmico (RVD). A CR3 provocou um prejuízo maior na condição de conjunção do que nas de faces e nomes (Exp 1). A SA e o RVD têm efeitos iguais e mais acentuados sobre a conjunção; a SA tem um efeito mais pronunciado do que o RVD nas condições de face e nome (Exp 2). O prejuízo maior da CR3 sobre a conjunção, em comparação com nomes e faces sugere que a integração de características visuais e verbais exigiu o envolvimento da atenção. Além disso, o efeito diferenciado da SA no armazenamento das características visuais e verbais isoladas sugere que estas podem ser armazenadas de maneira diferente quando integradas.The dual tasks paradigm was used to investigate the involvement of attention in the binding of verbal and visual information in working memory, and the specific role of these components when they are integrated. Two experiments were carried out, with 33 subjects, who memorized sequences of faces, names, or face-name conjunctions. In the Experiment1, these conditions were performed in separate blocks, either alone or with a backward counting in threes (CR3). In experiment2, these conditions were performed in separate blocks, with Articulatory Suppression (AS) and Dynamic Visual Noise (DVN). The CR3 caused greater loss in the conjunction than in the faces and names condition (Exp.1). The SA and the DVN have equivalent effect and they show more relevant effects in the conjunction condition. The SA revealed more relevant effect than the DVN in the face and name conditions (Exp.2). The greater prejudice of CR3 in binding, compared to that obtained in names and faces suggested that the integration of visual and verbal features demanded the involvement of attention. Moreover, the differential effect of SA towards DVN in the storage of isolated visual and verbal features, suggests that they may be stored in different ways when integrated.
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Ellwanger, Daniel Christian [Verfasser], Hans-Werner [Akademischer Betreuer] Mewes, Lars [Akademischer Betreuer] Kaderali y Fabian J. [Akademischer Betreuer] Theis. "Computational modeling of miRNA-mediated gene regulation in consideration of miRNP binding information from AGO-bound CLIP-Seq data analysis / Daniel Christian Ellwanger. Gutachter: Lars Kaderali ; Fabian J. Theis ; Hans-Werner Mewes. Betreuer: Hans-Werner Mewes". München : Universitätsbibliothek der TU München, 2015. http://d-nb.info/1074640217/34.
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Dabosville, Benjamin. "L'information du salarié : contribution à l'étude de l'obligation d'informer". Thesis, Paris 10, 2011. http://www.theses.fr/2011PA100166.
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L’étude est centrée sur l’obligation pour l’employeur d’informer le salarié. La première partie met en évidence les diverses raisons d’être de ces informations obligatoires. Certaines sont liées à l’activité interne de la pensée. Elles visent soit à instaurer une discussion préalable à une prise de décision de l’employeur soit à donner au salarié la possibilité de faire preuve de discernement dans ses choix. D’autres informations sont, en revanche, liées à l’activité externe sur le monde. Certaines lui donnent au travailleur la possibilité de contrôler l’action de l’employeur tandis que d’autres lui confèrent une autonomie d’action. Cette diversité de fonctions se conjugue avec une relative unité dans les règles applicable à ces différentes obligations d’informer. L’employeur devant effectuer un acte de langage pour exécuter son obligation d’informer, il est ainsi toujours soumis aux mêmes exigences de précision, d’exactitude et de sincérité quelque soit la finalité de l’information. De même, il est parfois contraint de respecter certaines règles de forme. La diversité des sanctions de l’inexécution découle également de la nature particulière de l’information. Le salarié peut demander réparation pour le préjudice subi du fait d’un défaut d’information. Mais il peut aussi invoquer l’inopposabilité des éléments non communiquées. Enfin, il peut demander à ce que ses attentes légitimes soient protégées soit via l’interdiction de se contredire au détriment d’autrui, soit via l’effet obligatoire de l’informationThe study focuses on obligations of the employer to inform each one of its employee. The first part outlines the various roots of the obligations to inform. Some pieces of information are related to the internal activity of thought. The aim is to create a discussion prior to the employer’s decision either to give the employee the opportunity to exercise discretion. Additional information is, however, related to the activity on the external world. Some give the worker the ability to exercise a control on the employer’s action, whereas some others give an autonomy to the action. However the diversity in the functions of the oblitgaiton to inform, the rules are on the whole the same. In order to perform its obligation must express itself. This expression is always subjected to the same precision, accuracy and fairness regardless its purpose. Similarly, the employer may be forced to follow certain rules of form. The sanctions are different. Indeed, the employee may claim compensation for damages due to lack of information. But he can also invoke the unenforceability of undisclosure. Finally, he may request that his legitimate expectations are protected either through estoppel or via the binding effect of the information
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Lo, Yuet Mei. "Business process atomicity analysis supporting late task property bindings /". View abstract or full-text, 2005. http://library.ust.hk/cgi/db/thesis.pl?COMP%202005%20LO.
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Feldmann, Florian [Verfasser], Jörg [Akademischer Betreuer] Schwenk y Christina [Akademischer Betreuer] Pöpper. "Binding credentials : securing (SSO) authentication / Florian Feldmann. Gutachter: Jörg Schwenk ; Christina Pöpper". Bochum : Ruhr-Universität Bochum, 2016. http://d-nb.info/1081246677/34.
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Nicoletti, Alberto. "Meta-programmazione di binding OCaml per GTK3". Master's thesis, Alma Mater Studiorum - Università di Bologna, 2020. http://amslaurea.unibo.it/20508/.
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GTK è una delle principali librerie per costruire interfacce grafiche, ed essendo scritta in C sono molti i linguaggi che realizzano dei binding a questa libreria. GTK dispone di un sistema di introspezione in grado di generare un file XML che descrive l'intera API della libreria. Tramite questo meccanismo, per numerosi linguaggi sono state realizzate delle librerie in grado di leggere questo file XML e generare automaticamente i binding per GTK.
Nel caso di OCaml invece esiste la libreria lablgtk, la quale è però scritta a mano: questo permette di avere una API più vicina ai costrutti idiomatici del linguaggio, ma incompleta, sensibile ai cambi di versione e prona ad errori.
L'obiettivo raggiunto in questa tesi è la realizzazione di un prototipo funzionante in grado di generare automaticamente i binding di GTK per OCaml. Il prototipo è stato ottenuto modificando haskell-gi, la libreria analoga per Haskell, un linguaggio simile ad OCaml che ha dovuto affrontare problematiche simili. In particolare questa libreria è composta di due moduli principali, uno per la lettura del file XML, ed uno per la generazione del codice Haskell a partire dalle informazioni ottenute dal parsing. In ocaml-gi-gtk, la libreria creata in questa tesi, è stato riusato completamente il modulo di parsing, ma è stato riscritto il modulo di generazione del codice per generare codice OCaml invece che Haskell.
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Munteanu, Alina. "Computational models to investigate binding mechanisms of regulatory proteins". Doctoral thesis, Humboldt-Universität zu Berlin, 2018. http://dx.doi.org/10.18452/19148.
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Es gibt tausende regulatorische Proteine in Eukaryoten, die spezifische cis-regulatorischen Elemente von Genen und/oder RNA-Transkripten binden und die Genexpession koordinieren. Auf DNA-Ebene modulieren Transkriptionsfaktoren (TFs) die Initiation der Transkription, während auf RNA-Ebene RNA-bindende Proteine (RBPs) viele Aspekte des RNA-Metabolismus und der RNA-Funktion regulieren. Für hunderte dieser regulatorischer Proteine wurden die gebundenen Gene beziehungsweise RNA-Transkripte, sowie deren etwaige Sequenzbindepräferenzen mittels in vivo oder in vitro Hochdurchsatz-Experimente bestimmt. Zu diesen Methoden zählen unter anderem Chromatin-Immunpräzipitation (ChIP) gefolgt von Sequenzierung (ChIP-seq) und Protein Binding Microarrays (PBMs) für TFs, sowie Cross-Linking und Immunpräzipitation (CLIP)-Techniken und RNAcompete für RBPs. In vielen Fällen kann die zum Teil hohe Bindespezifität für ein zumeist sehr kurzes Sequenzmotiv regulatorischer Proteine nicht allein durch die gebundene Primärsequenz erklärt werden.
Um besser zu verstehen, wie verschiedene Proteine ihre regulatorische Spezifität erreichen, haben wir zwei Computerprogramme entwickelt, die zusätzliche Informationen in die Analyse von experimentell bestimmten Bindestellen einbeziehen und somit differenziertere Bindevorhersagen ermöglichen. Für Protein-DNA-Interaktionen untersuchen wir die Bindungsspezifität paraloger TFs (d.h. Mitglieder der gleichen TF-Familie). Mit dem Fokus auf der Unterscheidung von genomischen Regionen, die in vivo von Paaren eng miteinander verwandter TFs gebunden sind, haben wir ein Klassifikationsframework entwickelt, das potenzielle Co-Faktoren identifiziert, die zur Spezifität paraloger TFs beitragen. Für Protein-RNA-Interaktionen untersuchen wir die Rolle von RNA-Sekundärstruktur und ihre Auswirkung auf die Auswahl von Bindestellen. Wir haben einen Motif-Finding-Algorithmus entwickelt, der Sekundärstruktur und Primärsequenz integriert, um Bindungspräferenzen der RBPs besser zu bestimmen.There are thousands of eukaryotic regulatory proteins that bind to specific cis regulatory regions of genes and/or RNA transcripts and coordinate gene expression. At the DNA level, transcription factors (TFs) modulate the initiation of transcription, while at the RNA level, RNA-binding proteins (RBPs) regulate every aspect of RNA metabolism and function. The DNA or RNA targets and/or the sequence preferences of hundreds of eukaryotic regulatory proteins have been determined thus far using high-throughput in vivo and in vitro experiments, such as chromatin immunoprecipitation (ChIP) followed by sequencing (ChIP-seq) and protein binding microarrays (PBMs) for TFs, or cross-linking and immunoprecipitation (CLIP) techniques and RNAcompete for RBPs. However, the derived short sequence motifs do not fully explain the highly specific binding of these regulatory proteins. In order to improve our understanding of how different proteins achieve their regulatory specificity, we developed two computational tools that incorporate additional information in the analysis of experimentally determined binding sites. For protein-DNA interactions, we investigate the binding specificity of paralogous TFs (i.e. members of the same TF family). Focusing on distinguishing between genomic regions bound in vivo by pairs of closely-related TFs, we developed a classification framework that identifies putative co-factors that provide specificity to paralogous TFs. For protein-RNA interactions, we investigate the role of RNA secondary structure and its impact on binding-site recognition. We developed a motif finding algorithm that integrates secondary structure together with primary sequence in order to better identify binding preferences of RBPs.
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Drusiani, Alberto. "Conversione in OCaml della libreria ocaml-gi-gtk". Master's thesis, Alma Mater Studiorum - Università di Bologna, 2021. http://amslaurea.unibo.it/23335/.
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L’utilizzo in larga scala della libreria grafica GTK implementata in C ha forzato gli sviluppatori della stessa a rendere semplice la creazione di binding ad essa con linguaggi
di alto livello. Esistono due tipi di binding: manuale e automatico. Il binding automatico permette di svincolarsi dalle modifiche che vengono effettuate a GTK, rendendo
il processo di binding più robusto. OCaml, linguaggio di programmazione emergente e
multi-paradigma, non possiede una libreria di binding automatici per GTK scritta in
OCaml, ma una libreria scritta in Haskell chiamata ocaml-gi-gtk e sviluppata all’interno
dell’Università di Bologna.
Questo progetto ha lo scopo di convertire in OCaml questa libreria, in modo che possa
essere addottata dalla community del linguaggio. È spesso infatti presente una sorta di
tendenza all’autarchia nel mondo dei linguaggi di programmazione, che rende riluttanti
gli utilizzatori di un linguaggio nei confronti di uno simile e "concorrente"
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Adasme, Melissa F. [Verfasser], Michael [Gutachter] Schroeder, Michael [Akademischer Betreuer] Schroeder y Olga [Gutachter] Kalinina. "Structure based drug repositioning by exploiting structural properties of drug's binding mode / Melissa F. Adasme ; Gutachter: Michael Schroeder, Olga Kalinina ; Betreuer: Michael Schroeder". Dresden : Technische Universität Dresden, 2021. http://d-nb.info/1237320070/34.
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Arroyo, Delgado Gustavo. "Evaluación Parcial Offline Dirigida por Narrowing: Técnicas de Optimización y Aplicaciones". Doctoral thesis, Universitat Politècnica de València, 2012. http://hdl.handle.net/10251/17655.
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La evaluación parcial (EP) de programas es una técnica formal para
la especialización y optimización de programas. Un evaluador parcial
toma un programa y sólo una parte de sus datos de entrada (los llamados
datos estáticos) e intenta llevar a cabo todas las computaciones
que sean posibles a partir de tales datos. El evaluador parcial devuelve
un programa nuevo, denominado programa residual el cual se ejecuta
generalmente de manera más e ciente que el programa original, ya que
las computaciones que dependen de los datos estáticos se han realizado
en la fase de evaluación parcial de una vez y para siempre [JGS93]. La
evaluación parcial es una técnica de optimización de programas basada
en semántica la cual ha sido investigada dentro de diferentes paradigmas
de programación y aplicada a una amplia variedad de lenguajes. También es conocida como una técnica de transformación de programas
fuente-a-fuente para especializar programas con respecto a una parte de
sus datos de entrada (por ello también es conocida como especialización
de programas). La evaluación parcial ha sido intensamente aplicada en
el área de la programación funcional [CD93, JGS93, Tur86] y en programaci
ón lógica [Gal93, Kom82b, LS91, PP94], donde ésta es normalmente
conocida como deducción parcial. También en lenguajes imperativos
como C en [TBC+98], o aplicada a un subconjunto importante de C
en [And92] donde reportan la primera implementación autoaplicable de
evaluación parcial para un lenguaje imperativo. Y en lenguajes formales
como Scheme en [Jør92a, Jør92b] donde generan compiladores a partir
de intérpretes.
Cuando tenemos un programa sólo con algunos de sus datos de entrada
conocidos no podemos ejecutar el programa, sin embargo podemos
optimizar el programa computando respuestas tanto como sea posible.
La evaluación parcial es una técnica que permite la ejecución parcial de
un programa [MS97].Arroyo Delgado, G. (2012). Evaluación Parcial Offline Dirigida por Narrowing: Técnicas de Optimización y Aplicaciones [Tesis doctoral no publicada]. Universitat Politècnica de València. https://doi.org/10.4995/Thesis/10251/17655
Palancia
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Horst, Harald. "Wissensraum am Niederrhein". Doctoral thesis, Humboldt-Universität zu Berlin, Philosophische Fakultät I, 2017. http://dx.doi.org/10.18452/17761.
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Das Kreuzherrenkloster Hohenbusch bei Erkelenz (Niederrhein) wurde 1802 während der Säkularisation linksrheinischer Gebiete aufgehoben. Etwa 130 Handschriften und frühe Drucke aus seiner Bibliothek befinden sich heute vorwiegend in der Diözesanbibliothek Köln sowie in München, Brüssel, New York u.a. Ein 1801 im Auftrag der französischen Verwaltung erstelltes Inventar von 265 konfiszierten Büchern bildet das einzige Verzeichnis der ehemaligen Klosterbibliothek. Auf der Grundlage dieses Inventars und der erhaltenen Bestände unternimmt die Studie eine Teilrekonstruktion der Bibliothek. Schreibhände, Buchschmuck, Einbände, Besitzeinträge und Marginalien werden erfasst und beschrieben. Die inhaltliche Analyse des Bestandes belegt, dass sich Geschichte, Spiritualität und intellektuelle Ausrichtung des Klosters auch im Restbestand der Bibliothek spiegeln. Um sich in kulturhistorischer, interdisziplinärer Herangehensweise der sozialen und kulturellen Lebenswelt der Kreuzherren zu nähern, wird die Metapher des ‚Wissensraums‘ verwendet. Von dreidimensionaler Beschränkung befreit, umschreibt sie die Bibliothek als dynamischen Wissenskatalysator, der zu verschiedenen Zeiten die Generierung neuen Wissens auf der Grundlage vorhandener Informationen ermöglicht. Zwei Bestandsschnitte bei den Jahren 1520 und 1700 belegen so den Wandel des Klosters: Verstand es sich anfangs als geistlich-seelsorglich ausgerichtetes Haus, das später für die ordensinterne Ausbildung bedeutend wurde, ließen zuletzt Grundbesitz und zunehmender Wohlstand juristisch-administrative Fragen in den Vordergrund treten.The Crosier monastery of Hohenbusch, situated between Cologne and Aix-la-Chapelle, was dissolved in 1802, on the occasion of the secularization of church property. About 130 manuscripts and early prints from the canonry’s library survived in the diocesan library of Cologne, as well as in libraries in Munich, Brussels, New York etc. An inventory of 265 confiscated books, drawn up on behalf of the French administration in 1801, represents the only description of the former monastery library. The study attempts a reconstruction of the library based on this inventory, and on the material properties of the extant books. Script, book illumination, binding, ownership records and marginal notes in the books are therefore described. An analysis of the contents of the known books shows that they still reflect the history, spirituality, and intellectual bias of the canonry. The German metaphor ‘Wissensraum’ (knowledge space) shall help to approach the social and cultural life of the Crosiers. Perceived as a cultural concept beyond all restrictions of space, the metaphor aims to describe the library as a dynamic instrument which allows generating new knowledge based on existing information. A look on two segments of the library, the first up to the year 1520, the second up to 1700, shows how the monastery changed: Starting in a spiritual and pastoral orientation, it became an important house for the spiritual formation of novices, while at the end, due to its increasing land ownership, and prosperity, legal and administrative questions predominated.
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Peci, Erind. "Implementazione e Dimostrazione di un Client Mobile Completo per l'Arrowhead Framework". Bachelor's thesis, Alma Mater Studiorum - Università di Bologna, 2020.
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Come spiega l’autore Kevin Ashton di “How to fly a horse: The secret history of creation, invention, and discovery“, negli anni "90 la creazione di sensori collegati a Internet non era una pratica diffusa e "l’idea di creare una vasta rete di sensori per raccogliere dati sulle cose nel mondo reale sembrava molto strana".
\newline Oggi, dopo anni di sviluppo tecnologico , è cambiato non solo l'idea per i sensori ma anche la necessità di dare un identità informatica ad ogni oggetto fisico nel contesto della rete dell'Internet of Things.L'idea di dotare queste entità con la capacità di scambiare informazioni e di utilizzare le informazioni che sono state scambiate orienta l'infrastruttura informatica verso i servizi.\newline Avendo presente l'impatto che presentano oggi i sistemi automatizzati negli ambienti IT , minimizzando le inefficienze dovute all’intervento umano, Arrowhead Framework fornisce un’architettura per la creazione di sistemi di automazione basati su Internet of Things secondo i principi della sicurezza IT, la scalabilità del sistema e la semplicità di progettazione.
\newline In questa tesi si trattano argomenti legati all'architettura orientata ai servizi,l'interoperabilità e si da una dimostrazione reale dell'esecuzione di questi principi nel contesto di un sistema che funziona secondo il framework Arrowhead.
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Cheng-HaoHsueh y 薛正豪. "Predicting DNA-binding Proteins using Disorder Information". Thesis, 2010. http://ndltd.ncl.edu.tw/handle/67963501384338121343.
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碩士國立成功大學
電機工程學系碩博士班
98
Background: Identifying DNA-binding proteins (DBPs) that play a crucial role in the regulation network is an important task of proteomics and genome annotation. DBPs have been shown to be recognizable by their structure and sequence characteristics. Methods based on structure information achieved better performance, while methods based on only sequence information have broader applications since they can be applied on proteins without crystallized structures. A compromising strategy is to use predicted structure information. In recent years, secondary structure and solvent accessibility are the two structure features that have reliable prediction packages and have been incorporated to predict DBPs with some successes. Results: There have been many biological evidences revealing that the process of DNA-binding probably leads to conformational changes of disorder-to-order, the so-called induced folding. Thus, the proposed method aims to include the predicted protein disorder information. This is the first study using such information for DBP prediction. A protein sequence in this study is described by four groups of features: a) amino acid composition, b) position specific scoring matrix (PSSM) obtained with PSI-BLAST c) proportion of order and disorder regions and d) secondary structure composition in the ordered region. The first two groups are widely used in previous studies; the third group is based on the predicted disorder information; and the last group combines both predicted secondary structure and disorder information. The experimental results show that the proposed method (81.3% F-measure) outperformed the two compared methods (64.1% and 76.7% F-measure). We also analyzed the Protein Data Bank database and found there were around 20% of DBPs undergo disorder-to-order transition upon binding DNA. These results encourage more efforts on exploiting protein disorder information in DBP prediction. Conclusions: DNA-binding proteins participate in various cellular processes, and characterization of these proteins is of great importance. We proposed a novel DBP predictor with predicted secondary structure and disorder information. Its promising performance revealed the importance of disordered regions in DNA-binding proteins
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Zhao, Huiying. "Protein function prediction by integrating sequence, structure and binding affinity information". Thesis, 2014. http://hdl.handle.net/1805/3913.
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Indiana University-Purdue University Indianapolis (IUPUI)Proteins are nano-machines that work inside every living organism. Functional disruption of one or several proteins is the cause for many diseases. However, the functions for most proteins are yet to be annotated because inexpensive sequencing techniques dramatically speed up discovery of new protein sequences (265 million and counting) and experimental examinations of every protein in all its possible functional categories are simply impractical. Thus, it is necessary to develop computational function-prediction tools that complement and guide experimental studies. In this study, we developed a series of predictors for highly accurate prediction of proteins with DNA-binding, RNA-binding and carbohydrate-binding capability. These predictors are a template-based technique that combines sequence and structural information with predicted binding affinity. Both sequence and structure-based approaches were developed. Results indicate the importance of binding affinity prediction for improving sensitivity and precision of function prediction. Application of these methods to the human genome and structure genome targets demonstrated its usefulness in annotating proteins of unknown functions and discovering moon-lighting proteins with DNA,RNA, or carbohydrate binding function. In addition, we also investigated disruption of protein functions by naturally occurring genetic variations due to insertions and deletions (INDELS). We found that protein structures are the most critical features in recognising disease-causing non-frame shifting INDELs. The predictors for function predictions are available at http://sparks-lab.org/spot, and the predictor for classification of non-frame shifting INDELs is available at http://sparks-lab.org/ddig.
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Benner, Philipp. "Combining Prior Information for the Prediction of Transcription Factor Binding Sites". 2015. https://ul.qucosa.de/id/qucosa%3A21541.
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Despite the fact that each cell in an organism has the same genetic information, it is possible that cells fundamentally differ in their function. The molecular basis for the functional diversity of cells is governed by biochemical processes that regulate the expression of genes. Key to this regulatory process are proteins called transcription factors that recognize and bind specific DNA sequences of a few nucleotides. Here we tackle the problem of identifying the binding sites of a given transcription factor. The prediction of binding preferences from the structure of a transcription factor is still an unsolved problem. For that reason, binding sites are commonly identified by searching for overrepresented sites in a given collection of nucleotide sequences. Such sequences might be known regulatory regions of genes that are assumed to be coregulated, or they are obtained from so-called ChIP-seq experiments that identify approximately the sites that were bound by a given transcription factor. In both cases, the observed nucleotide sequences are much longer than the actual binding sites and computational tools are required to uncover the actual binding preferences of a factor. Aggravated by the fact that transcription factors recognize not only a single nucleotide sequence, the search for overrepresented patterns in a given collection of sequences has proven to be a challenging problem.
Most computational methods merely relied on the given set of sequences, but additional information is required in order to make reliable predictions. Here, this information is obtained by looking at the evolution of nucleotide sequences. For that reason, each nucleotide sequence in the observed data is augmented by its orthologs, i.e. sequences from related species where the same transcription factor is present. By constructing multiple sequence alignments of the orthologous sequences it is possible to identify functional regions that are under selective pressure and therefore appear more conserved than others. The processing of the additional information exerted by ortholog sequences relies on a phylogenetic tree equipped with a nucleotide substitution model that not only carries information about the ancestry, but also about the expected similarity of functional sites.
As a result, a Bayesian method for the identification of transcription factor binding sites is presented. The method relies on a phylogenetic tree that agrees with the assumptions of the nucleotide substitution process. Therefore, the problem of estimating phylogenetic trees is discussed first. The computation of point estimates relies on recent developments in Hadamard spaces. Second, the statistical model is presented that captures the enrichment and conservation of binding sites and other functional regions in the observed data. The performance of the method is evaluated on ChIP-seq data of transcription factors, where the binding preferences have been estimated in previous studies.
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Shahzad, Nabeel. "S.IM.PL Serialization: Type System Scopes Encapsulate Cross-Language, Multi-Format Information Binding". Thesis, 2011. http://hdl.handle.net/1969.1/ETD-TAMU-2011-12-10410.
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Representing data outside of and between programs is important in software that stores, shares, and manipulates information. Formats for representing information, varying from human-readable verbose (XML) to light-weight, concise (JSON), and non-human-readable formats (TLV) have been developed and used by applications based on their data and communication requirements. Writing correct programs that produce information represented in these formats is a difficult and time-consuming task, as developers must write repetitive, tedious code to map loosely-typed serialized data to strongly-typed program objects. We developed S.IM.PL Serialization, a cross-language multi-format information binding framework to relieve developers from the burdens associated with the serialization of strongly-typed data structures. We developed type system scopes, a means of encapsulating data types and binding semantics as a cross-language abstract semantics graph. In comparison to representing data binding semantics and information structure through external forms such as schemas, configuration files, and interface description languages, type system scopes can be automatically generated from declarations in a data binding annotation language, facilitating software engineering. Validation is based on use in research applications, a study of how computer science graduate students use the software to develop applications, and performance benchmarks. As a case study, we also examine the cross-language development of a Team Coordination (TeC) game.
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Chen, Wei-Jhih y 陳韋志. "Hidden Markov Model Based DNA-binding Proteins Prediction by Mining on Sequence and Structure Information". Thesis, 2008. http://ndltd.ncl.edu.tw/handle/20716134364431964671.
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碩士國立成功大學
醫學資訊研究所
96
In the post-genome period, the protein domain structures have been published rapidly. For figuring out the cell function, the mechanism of protein-DNA interaction is an important subject in resent bioinformatics research and has not been comprehensively studied. Several machine learning based methods have been attempted to solve this issue. Until recently, few studies have been successful in translating the tertiary structure characteristics of proteins into appropriate features for utilizing the learning mechanism to predict DNA-binding Proteins. In this work, a novel machine learning approach based on using HMMs (hidden Markov Models) to express the characteristics of DNA-binding Proteins in the both aspects of amino acid sequence and tertiary structure has been presented. Moreover, several helpful features of DNA-binding Proteins have also been utilized in the proposed method, such as residue composition, structure pattern composition and accessible surface area of residues. We also develop a SVM (Support Vector Machine) based classifier to predict general DNA-binding Proteins, and obtain the accuracy of 88.45% through 5-folds cross-validation. Furthermore, a response element specific classifier is constructed for predicting response element specific DNA-binding Proteins, and is obtained the precision of 96.57% with recall rate as 88.83% in average. Finally, this high accuracy classifier is employed to predict the DNA-binding Proteins from MCF-7 which likely to bind to estrogen response elements.
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Finger, Holger Ewald. "Information Processing in Neural Networks: Learning of Structural Connectivity and Dynamics of Functional Activation". Doctoral thesis, 2017. https://repositorium.ub.uni-osnabrueck.de/handle/urn:nbn:de:gbv:700-2017031615634.
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Adaptability and flexibility are some of the most important human characteristics. Learning based on new experiences enables adaptation by changing the structural connectivity of the brain through plasticity mechanisms. But the human brain can also adapt to new tasks and situations in a matter of milliseconds by dynamic coordination of functional activation. To understand how this flexibility can be achieved in the computations performed by neural networks, we have to understand how the relatively fixed structural backbone interacts with the functional dynamics. In this thesis, I will analyze these interactions between the structural network connectivity and functional activations and their dynamic interactions on different levels of abstraction and spatial and temporal scales.
One of the big questions in neuroscience is how functional interactions in the brain can adapt instantly to different tasks while the brain structure remains almost static. To improve our knowledge of the neural mechanisms involved, I will first analyze how dynamics in functional brain activations can be simulated based on the structural brain connectivity obtained with diffusion tensor imaging. In particular, I will show that a dynamic model of functional connectivity in the human cortex is more predictive of empirically measured functional connectivity than a stationary model of functional dynamics. More specifically, the simulations of a coupled oscillator model predict 54\% of the variance in the empirically measured EEG functional connectivity.
Hypotheses of temporal coding have been proposed for the computational role of these dynamic oscillatory interactions on fast timescales. These oscillatory interactions play a role in the dynamic coordination between brain areas as well as between cortical columns or individual cells. Here I will extend neural network models, which learn unsupervised from statistics of natural stimuli, with phase variables that allow temporal coding in distributed representations. The analysis shows that synchronization of these phase variables provides a useful mechanism for binding of activated neurons, contextual coding, and figure ground segregation. Importantly, these results could also provide new insights for improvements of deep learning methods for machine learning tasks.
The dynamic coordination in neural networks has also large influences on behavior and cognition. In a behavioral experiment, we analyzed multisensory integration between a native and an augmented sense. The participants were blindfolded and had to estimate their rotation angle based on their native vestibular input and the augmented information. Our results show that subjects alternate in the use between these modalities, indicating that subjects dynamically coordinate the information transfer of the involved brain regions. Dynamic coordination is also highly relevant for the consolidation and retrieval of associative memories. In this regard, I investigated the beneficial effects of sleep for memory consolidation in an electroencephalography (EEG) study. Importantly, the results demonstrate that sleep leads to reduced event-related theta and gamma power in the cortical EEG during the retrieval of associative memories, which could indicate the consolidation of information from hippocampal to neocortical networks. This highlights that cognitive flexibility comprises both dynamic organization on fast timescales and structural changes on slow timescales.
Overall, the computational and empirical experiments demonstrate how the brain evolved to a system that can flexibly adapt to any situation in a matter of milliseconds. This flexibility in information processing is enabled by an effective interplay between the structure of the neural network, the functional activations, and the dynamic interactions on fast time scales.
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Huang, Wanjun [Verfasser]. "Temporary binding for dynamic middleware construction and web services composition / von Wanjun Huang". 2006. http://d-nb.info/980539242/34.
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Petras, Christina [Verfasser]. "Binding von Objekt- und Lokalisationsinformationen im Arbeitsgedächtnis : eine Studie zum Einfluss kognitiver Fähigkeiten auf das Memorieren von Binding-Informationen / vorgelegt von Christina Petras". 2006. http://d-nb.info/982491476/34.
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Weng, Sebastian [Verfasser]. "Data driven learning for feature binding and perceptual grouping with the competitive layer model / vorgelegt von Sebastian Weng". 2005. http://d-nb.info/978674510/34.
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Maye, Alexander [Verfasser]. "Neuronale Synchronität, zeitliche Bindung und Wahrnehmung / vorgelegt von Alexander Maye". 2002. http://d-nb.info/966133676/34.
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König, Axel [Verfasser]. "Computergestützte Lehr- und Lernmaterialien zur chemischen Bindung : Entwicklung, Erprobung, Erhebung / Axel König". 2004. http://d-nb.info/972835997/34.
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Dang, Truong Khanh Linh. "Probabilistic Models to Detect Important Sites in Proteins". Doctoral thesis, 2020. http://hdl.handle.net/21.11130/00-1735-0000-0005-1583-F.
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Priesnitz, Andreas. "Multistage Algorithms in C++". Doctoral thesis, 2005. http://hdl.handle.net/11858/00-1735-0000-0006-B405-D.
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Sauer, Tilman. "Evaluierung des phylogenetischen Footprintings und dessen Anwendung zur verbesserten Vorhersage von Transkriptionsfaktor-Bindestellen". Doctoral thesis, 2006. http://hdl.handle.net/11858/00-1735-0000-0006-B383-8.
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