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Artículos de revistas sobre el tema "Cartilage cells. Osteoarthritis. Cartilage Cell differentiation"

Autor: Grafiati

Publicado: 4 de junio de 2021

Última modificación: 3 de febrero de 2022

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1

Cui, Dixin, Hongyu Li, Xin Xu, et al. "Mesenchymal Stem Cells for Cartilage Regeneration of TMJ Osteoarthritis." Stem Cells International 2017 (2017): 1–11. http://dx.doi.org/10.1155/2017/5979741.

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Temporomandibular joint osteoarthritis (TMJ OA) is a degenerative disease, characterized by progressive cartilage degradation, subchondral bone remodeling, synovitis, and chronic pain. Due to the limited self-healing capacity in condylar cartilage, traditional clinical treatments have limited symptom-modifying and structure-modifying effects to restore impaired cartilage as well as other TMJ tissues. In recent years, stem cell-based therapy has raised much attention as an alternative approach towards tissue repair and regeneration. Mesenchymal stem cells (MSCs), derived from the bone marrow, s

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2

Yang, Xiao, Lin Chen, Xiaoling Xu, Cuiling Li, Cuifen Huang та Chu-Xia Deng. "TGF-β/Smad3 Signals Repress Chondrocyte Hypertrophic Differentiation and Are Required for Maintaining Articular Cartilage". Journal of Cell Biology 153, № 1 (2001): 35–46. http://dx.doi.org/10.1083/jcb.153.1.35.

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Endochondral ossification begins from the condensation and differentiation of mesenchymal cells into cartilage. The cartilage then goes through a program of cell proliferation, hypertrophic differentiation, calcification, apoptosis, and eventually is replaced by bone. Unlike most cartilage, articular cartilage is arrested before terminal hypertrophic differentiation. In this study, we showed that TGF-β/Smad3 signals inhibit terminal hypertrophic differentiation of chondrocyte and are essential for maintaining articular cartilage. Mutant mice homozygous for a targeted disruption of Smad3 exon 8

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3

Wang, Qian, Na Yang, Kun Zhang, Zhong Li, Yangjun Zhu, and Zhe Song. "Effect of intra-articular injection of adipose stem cells on traumatic osteoarthritis cartilage defects." Materials Express 11, no. 1 (2021): 28–37. http://dx.doi.org/10.1166/mex.2021.1874.

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Traumatic osteoarthritis with cartilage defects can lead to mobility problems. Mitotic activity in cartilage is extremely low, and once damaged, repairing can be difficult. The commonly used autologous or allogeneic cartilage transplantation techniques also have certain limitations. In recent years, directed induction of osteoblastic differentiation using adipocytes has been shown to be effective in repairing cartilage defects. However, it is often induced in vitro and is prone to incomplete or over-differentiation. In addition, because of the large differences in the in vivo and in vitro micr

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4

Huh, Jeong-Eun, Yeon-Cheol Park, Byung-Kwan Seo, et al. "Cartilage Protective and Chondrogenic Capacity of WIN-34B, a New Herbal Agent, in the Collagenase-Induced Osteoarthritis Rabbit Model and in Progenitor Cells from Subchondral Bone." Evidence-Based Complementary and Alternative Medicine 2013 (2013): 1–12. http://dx.doi.org/10.1155/2013/527561.

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We sought to determine the cartilage repair capacity of WIN-34B in the collagenase-induced osteoarthritis rabbit model and in progenitor cells from subchondral bone. The cartilage protective effect of WIN-34B was measured by clinical and histological scores, cartilage area, and proteoglycan and collagen contents in the collagenase-induced osteoarthritis rabbit model. The efficacy of chondrogenic differentiation of WIN-34B was assessed by expression of CD105, CD73, type II collagen, and aggrecanin vivoand was analyzed by the surface markers of progenitor cells, the mRNA levels of chondrogenic m

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5

Shi, Jie, Jiulong Liang, Bingyu Guo, et al. "Adipose-Derived Stem Cells Cocultured with Chondrocytes Promote the Proliferation of Chondrocytes." Stem Cells International 2017 (2017): 1–17. http://dx.doi.org/10.1155/2017/1709582.

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Articular cartilage injury and defect caused by trauma and chronic osteoarthritis vascularity are very common, while the repair of injured cartilage remains a great challenge due to its limited healing capacity. Stem cell-based tissue engineering provides a promising treatment option for injured articular cartilage because of the cells potential for multiple differentiations. However, its application has been largely limited by stem cell type, number, source, proliferation, and differentiation. We hypothesized that (1) adipose-derived stem cells are ideal seed cells for articular cartilage rep

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6

Suchorska, Wiktoria Maria, Ewelina Augustyniak, Magdalena Richter, et al. "Modified methods for efficiently differentiating human embryonic stem cells into chondrocyte-like cells." Postępy Higieny i Medycyny Doświadczalnej 71, no. 1 (2017): 0. http://dx.doi.org/10.5604/01.3001.0010.3831.

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Human articular cartilage has a poor regenerative capacity. This often results in the serious joint disease- osteoarthritis (OA) that is characterized by cartilage degradation. An inability to self-repair provided extensive studies on AC regeneration. The cell-based cartilage tissue engineering is a promising approach for cartilage regeneration. So far, numerous cell types have been reported to show chondrogenic potential, among others human embryonic stem cells (hESCs).

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7

Dubey, Navneet Kumar, Viraj Krishna Mishra, Rajni Dubey, et al. "Combating Osteoarthritis through Stem Cell Therapies by Rejuvenating Cartilage: A Review." Stem Cells International 2018 (2018): 1–13. http://dx.doi.org/10.1155/2018/5421019.

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Knee osteoarthritis (OA) is a chronic degenerative disorder which could be distinguished by erosion of articular cartilage, pain, stiffness, and crepitus. Not only aging-associated alterations but also the metabolic factors such as hyperglycemia, dyslipidemia, and obesity affect articular tissues and may initiate or exacerbate the OA. The poor self-healing ability of articular cartilage due to limited regeneration in chondrocytes further adversely affects the osteoarthritic microenvironment. Traditional and current surgical treatment procedures for OA are limited and incapable to reverse the d

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8

Goldring, Mary B. "Chondrogenesis, chondrocyte differentiation, and articular cartilage metabolism in health and osteoarthritis." Therapeutic Advances in Musculoskeletal Disease 4, no. 4 (2012): 269–85. http://dx.doi.org/10.1177/1759720x12448454.

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Chondrogenesis occurs as a result of mesenchymal cell condensation and chondroprogenitor cell differentiation. Following chondrogenesis, the chondrocytes remain as resting cells to form the articular cartilage or undergo proliferation, terminal differentiation to chondrocyte hypertrophy, and apoptosis in a process termed endochondral ossification, whereby the hypertrophic cartilage is replaced by bone. Human adult articular cartilage is a complex tissue of matrix proteins that varies from superficial to deep layers and from loaded to unloaded zones. A major challenge to efforts to repair carti

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9

Koh, Yong-Gon, Jin-Ah Lee, Hwa-Yong Lee, Hyo-Jeong Kim, and Kyoung-Tak Kang. "Biomechanical Evaluation of the Effect of Mesenchymal Stem Cells on Cartilage Regeneration in Knee Joint Osteoarthritis." Applied Sciences 9, no. 9 (2019): 1868. http://dx.doi.org/10.3390/app9091868.

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Numerous clinical studies have reported cell-based treatments for cartilage regeneration in knee joint osteoarthritis using mesenchymal stem cells (MSCs). However, the post-surgery rehabilitation and weight-bearing times remain unclear. Phenomenological computational models of cartilage regeneration have been only partially successful in predicting experimental results and this may be due to simplistic modeling assumptions and loading conditions of cellular activity. In the present study, we developed a knee joint model of cell and tissue differentiation based on a more mechanistic approach, w

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10

Uzieliene, Ilona, Daiva Bironaite, Paulius Bernotas, Arkadij Sobolev, and Eiva Bernotiene. "Mechanotransducive Biomimetic Systems for Chondrogenic Differentiation In Vitro." International Journal of Molecular Sciences 22, no. 18 (2021): 9690. http://dx.doi.org/10.3390/ijms22189690.

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Osteoarthritis (OA) is a long-term chronic joint disease characterized by the deterioration of bones and cartilage, which results in rubbing of bones which causes joint stiffness, pain, and restriction of movement. Tissue engineering strategies for repairing damaged and diseased cartilage tissue have been widely studied with various types of stem cells, chondrocytes, and extracellular matrices being on the lead of new discoveries. The application of natural or synthetic compound-based scaffolds for the improvement of chondrogenic differentiation efficiency and cartilage tissue engineering is o

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11

Ruscitto, A., V. Scarpa, M. Morel, S. Pylawka, C. J. Shawber, and M. C. Embree. "Notch Regulates Fibrocartilage Stem Cell Fate and Is Upregulated in Inflammatory TMJ Arthritis." Journal of Dental Research 99, no. 10 (2020): 1174–81. http://dx.doi.org/10.1177/0022034520924656.

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The Notch pathway is critical for the development of the extracellular matrix in cartilage by regulating both anabolic and catabolic cellular activities. Similarly, Notch signaling plays a biphasic role in adult cartilage health and osteoarthritis by maintaining homeostasis and contributing to degeneration, respectively. The temporomandibular joint (TMJ) is the synovial joint of the craniofacial complex and is subject to injury and osteoarthritis. While Notch has been studied in axial skeletal joints, little is known about the role of Notch in TMJ development and disease. We identified fibroca

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12

Rim, Yeri Alice, Yoojun Nam, Narae Park, et al. "Different Chondrogenic Potential among Human Induced Pluripotent Stem Cells from Diverse Origin Primary Cells." Stem Cells International 2018 (2018): 1–13. http://dx.doi.org/10.1155/2018/9432616.

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Scientists have tried to reprogram various origins of primary cells into human induced pluripotent stem cells (hiPSCs). Every somatic cell can theoretically become a hiPSC and give rise to targeted cells of the human body. However, there have been debates on the controversy about the differentiation propensity according to the origin of primary cells. We reprogrammed hiPSCs from four different types of primary cells such as dermal fibroblasts (DF, n=3), peripheral blood mononuclear cells (PBMC, n=3), cord blood mononuclear cells (CBMC, n=3), and osteoarthritis fibroblast-like synoviocytes (OAF

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13

Messaoudi, Océane, Christel Henrionnet, Kevin Bourge, Damien Loeuille, Pierre Gillet, and Astrid Pinzano. "Stem Cells and Extrusion 3D Printing for Hyaline Cartilage Engineering." Cells 10, no. 1 (2020): 2. http://dx.doi.org/10.3390/cells10010002.

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Hyaline cartilage is deficient in self-healing properties. The early treatment of focal cartilage lesions is a public health challenge to prevent long-term degradation and the occurrence of osteoarthritis. Cartilage tissue engineering represents a promising alternative to the current insufficient surgical solutions. 3D printing is a thriving technology and offers new possibilities for personalized regenerative medicine. Extrusion-based processes permit the deposition of cell-seeded bioinks, in a layer-by-layer manner, allowing mimicry of the native zonal organization of hyaline cartilage. Mese

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14

Csobonyeiova, Maria, Stefan Polak, Andreas Nicodemou, Radoslav Zamborsky, and Lubos Danisovic. "iPSCs in Modeling and Therapy of Osteoarthritis." Biomedicines 9, no. 2 (2021): 186. http://dx.doi.org/10.3390/biomedicines9020186.

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Osteoarthritis (OA) belongs to chronic degenerative disorders and is often a leading cause of disability in elderly patients. Typically, OA is manifested by articular cartilage erosion, pain, stiffness, and crepitus. Currently, the treatment options are limited, relying mostly on pharmacological therapy, which is often related to numerous complications. The proper management of the disease is challenging because of the poor regenerative capacity of articular cartilage. During the last decade, cell-based approaches such as implantation of autologous chondrocytes or mesenchymal stem cells (MSCs)

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15

Thorp, Hallie, Kyungsook Kim, Makoto Kondo, Travis Maak, David W. Grainger, and Teruo Okano. "Trends in Articular Cartilage Tissue Engineering: 3D Mesenchymal Stem Cell Sheets as Candidates for Engineered Hyaline-Like Cartilage." Cells 10, no. 3 (2021): 643. http://dx.doi.org/10.3390/cells10030643.

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Articular cartilage defects represent an inciting factor for future osteoarthritis (OA) and degenerative joint disease progression. Despite multiple clinically available therapies that succeed in providing short term pain reduction and restoration of limited mobility, current treatments do not reliably regenerate native hyaline cartilage or halt cartilage degeneration at these defect sites. Novel therapeutics aimed at addressing limitations of current clinical cartilage regeneration therapies increasingly focus on allogeneic cells, specifically mesenchymal stem cells (MSCs), as potent, banked,

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16

Lee, Jiyun, Chang Youn Lee, Jun-Hee Park, et al. "Differentiation of adipose-derived stem cells into functional chondrocytes by a small molecule that induces Sox9." Experimental & Molecular Medicine 52, no. 4 (2020): 672–81. http://dx.doi.org/10.1038/s12276-020-0424-y.

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Abstract Osteoarthritis (OA) is a common joint disease that results from the disintegration of joint cartilage and the underlying bone. Because cartilage and chondrocytes lack the ability to self-regenerate, efforts have been made to utilize stem cells to treat OA. Although various methods have been used to differentiate stem cells into functional chondrocytes, the currently available methods cannot induce stem cells to undergo differentiation into chondrocyte-like cells without inducing characteristics of hypertrophic chondrocytes, which finally lead to cartilage disintegration and calcificat

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17

Cota, Perla, Summer A. Helmi, Charlie Hsu, and Derrick E. Rancourt. "Cytokine Directed Chondroblast Trans-Differentiation: JAK Inhibition Facilitates Direct Reprogramming of Fibroblasts to Chondroblasts." Cells 9, no. 1 (2020): 191. http://dx.doi.org/10.3390/cells9010191.

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Osteoarthritis (OA) is a degenerative disease of the hyaline articular cartilage. This disease is progressive and may lead to disability. Researchers proposed many regenerative approaches to treat osteoarthritis, including stem cells. Trans-differentiation of a fully differentiated cell state directly into another different differentiated cell state avoids the disadvantages of fully reprogramming cells to induced pluripotent stem cells (iPSCs) in terms of faster reprogramming of the needed cells. Trans-differentiation also reduces the risk of tumor formation by avoiding the iPSC state. OSKM fa

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18

Xing, Dan, Wei Liu, Bin Wang, et al. "Intra-articular Injection of Cell-laden 3D Microcryogels Empower Low-dose Cell Therapy for Osteoarthritis in a Rat Model." Cell Transplantation 29 (January 1, 2020): 096368972093214. http://dx.doi.org/10.1177/0963689720932142.

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Intra-articular injection of mesenchymal stem cells (MSCs) in an osteoarthritic joint can help slow down cartilage destruction. However, cell survival and the efficiency of repair are generally low due to mechanical damage during injection and a high rate of cell loss. We, thus, investigated an improved strategy for cell delivery to an osteoarthritic joint through the use of three-dimensional (3D) microcryogels. MSCs were seeded into 3D microcryogels. The viability and proliferation of MSCs in microcryogels were determined over 5 d, and the phenotype of MSCs was confirmed through trilineage di

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19

Ding, Nan, Ermao Li, Xiangbin Ouyang, Jin Guo, and Bo Wei. "The Therapeutic Potential of Bone Marrow Mesenchymal Stem Cells for Articular Cartilage Regeneration in Osteoarthritis." Current Stem Cell Research & Therapy 16, no. 7 (2021): 840–47. http://dx.doi.org/10.2174/1574888x16666210127130044.

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Osteoarthritis (OA), characterized by the degeneration and destruction of articular cartilage, is one of the most significant public health issues around the world. In the course of OA, inflammatory response is an important factor leading to cartilage destruction and exacerbation of symptoms. The low immunogenicity, multi-directional differentiation and high portability properties make bone marrow mesenchymal stem cells (BMSCs) ideal seed cells for OA. Here, we review recent literature relating to the application of BMSCs for OA cell therapy and consider the following aspects: migration and ho

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20

Lee, Yeon-Hee, Hee-Kyung Park, Q.-Schick Auh, et al. "Emerging Potential of Exosomes in Regenerative Medicine for Temporomandibular Joint Osteoarthritis." International Journal of Molecular Sciences 21, no. 4 (2020): 1541. http://dx.doi.org/10.3390/ijms21041541.

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Exosomes are nanosized vesicles (30–140 nm) of endocytic origin that play important roles in regenerative medicine. They are derived from cell membranes during endocytic internalization and stabilize in biological fluids such as blood and synovia. Temporomandibular joint osteoarthritis (TMJ OA) is a degenerative disease, which, in addition to chronic pain, is characterized by progressive cartilage breakdown, condylar bone remodeling, and synovitis. However, traditional clinical treatments have limited symptom- and structure-modifying effects to restore damaged cartilage and other TMJ tissues.

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21

Chen, Yawen, Xinli Ouyang, Yide Wu, Shaojia Guo, Yongfang Xie, and Guohui Wang. "Co-culture and Mechanical Stimulation on Mesenchymal Stem Cells and Chondrocytes for Cartilage Tissue Engineering." Current Stem Cell Research & Therapy 15, no. 1 (2020): 54–60. http://dx.doi.org/10.2174/1574888x14666191029104249.

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Defects in articular cartilage injury and chronic osteoarthritis are very widespread and common, and the ability of injured cartilage to repair itself is limited. Stem cell-based cartilage tissue engineering provides a promising therapeutic option for articular cartilage damage. However, the application of the technique is limited by the number, source, proliferation, and differentiation of stem cells. The co-culture of mesenchymal stem cells and chondrocytes is available for cartilage tissue engineering, and mechanical stimulation is an important factor that should not be ignored. A combinati

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22

Serra, Rosa, Mahlon Johnson, Ellen H. Filvaroff та ін. "Expression of a Truncated, Kinase-Defective TGF-β Type II Receptor in Mouse Skeletal Tissue Promotes Terminal Chondrocyte Differentiation and Osteoarthritis". Journal of Cell Biology 139, № 2 (1997): 541–52. http://dx.doi.org/10.1083/jcb.139.2.541.

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Members of the TGF-β superfamily are important regulators of skeletal development. TGF-βs signal through heteromeric type I and type II receptor serine/threonine kinases. When over-expressed, a cytoplasmically truncated type II receptor can compete with the endogenous receptors for complex formation, thereby acting as a dominant-negative mutant (DNIIR). To determine the role of TGF-βs in the development and maintenance of the skeleton, we have generated transgenic mice (MT-DNIIR-4 and -27) that express the DNIIR in skeletal tissue. DNIIR mRNA expression was localized to the periosteum/perichon

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23

Zhao, Yunchang, Honghao Liu, Chunjie Zhao, Peng Dang, Haijian Li, and Maryam Farzaneh. "Paracrine Interactions Involved in Human Induced Pluripotent Stem Cells Differentiation into Chondrocytes." Current Stem Cell Research & Therapy 15, no. 3 (2020): 233–42. http://dx.doi.org/10.2174/1574888x15666191224122058.

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Osteoarthritis (OA), as a degenerative joint disease, is the most common form of joint disorder that causes pain, stiffness, and other symptoms associated with OA. Various genetic, biomechanical, and environmental factors have a relevant role in the development of OA. To date, extensive efforts are currently being made to overcome the poor self-healing capacity of articular cartilage. Despite the pivotal role of chondrocytes, their proliferation and repair capacity after tissue injury are limited. Therefore, the development of new strategies to overcome these constraints is urgently needed. Re

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24

Medvedeva, Ekaterina, Ekaterina Grebenik, Svetlana Gornostaeva, et al. "Repair of Damaged Articular Cartilage: Current Approaches and Future Directions." International Journal of Molecular Sciences 19, no. 8 (2018): 2366. http://dx.doi.org/10.3390/ijms19082366.

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Articular hyaline cartilage is extensively hydrated, but it is neither innervated nor vascularized, and its low cell density allows only extremely limited self-renewal. Most clinical and research efforts currently focus on the restoration of cartilage damaged in connection with osteoarthritis or trauma. Here, we discuss current clinical approaches for repairing cartilage, as well as research approaches which are currently developing, and those under translation into clinical practice. We also describe potential future directions in this area, including tissue engineering based on scaffolding a

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25

Jiang, Shuangpeng, Guangzhao Tian, Xu Li, et al. "Research Progress on Stem Cell Therapies for Articular Cartilage Regeneration." Stem Cells International 2021 (February 12, 2021): 1–25. http://dx.doi.org/10.1155/2021/8882505.

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Injury of articular cartilage can cause osteoarthritis and seriously affect the physical and mental health of patients. Unfortunately, current surgical treatment techniques that are commonly used in the clinic cannot regenerate articular cartilage. Regenerative medicine involving stem cells has entered a new stage and is considered the most promising way to regenerate articular cartilage. In terms of theories on the mechanism, it was thought that stem cell-mediated articular cartilage regeneration was achieved through the directional differentiation of stem cells into chondrocytes. However, re

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Kristjánsson, Baldur, and Sittisak Honsawek. "Current Perspectives in Mesenchymal Stem Cell Therapies for Osteoarthritis." Stem Cells International 2014 (2014): 1–13. http://dx.doi.org/10.1155/2014/194318.

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Osteoarthritis (OA) is a degenerative joint disease most commonly occurring in the ageing population. It is a slow progressive condition resulting in the destruction of hyaline cartilage followed by pain and reduced activity. Conventional treatments have little effects on the progression of the condition often leaving surgery as the last option. In the last 10 years tissue engineering utilising mesenchymal stem cells has been emerging as an alternative method for treating OA. Mesenchymal stem cells (MSCs) are multipotent progenitor cells found in various tissues, most commonly bone marrow and

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27

Chawla, Shikha, Majoska H. M. Berkelaar, Boris Dasen, et al. "Blockage of bone morphogenetic protein signalling counteracts hypertrophy in a human osteoarthritic micro-cartilage model." Journal of Cell Science 133, no. 23 (2020): jcs249094. http://dx.doi.org/10.1242/jcs.249094.

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ABSTRACTBone morphogenetic protein (BMP) signalling plays a significant role during embryonic cartilage development and has been associated with osteoarthritis (OA) pathogenesis, being in both cases involved in triggering hypertrophy. Inspired by recent findings that BMP inhibition counteracts hypertrophic differentiation of human mesenchymal progenitors, we hypothesized that selective inhibition of BMP signalling would mitigate hypertrophic features in OA cartilage. First, a 3D in vitro OA micro-cartilage model was established using minimally expanded OA chondrocytes that was reproducibly abl

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Masutani, Teruaki, Shuhei Yamada, Akira Hara, Tatsuji Takahashi, Paul G. Green, and Masayuki Niwa. "Exogenous Application of Proteoglycan to the Cell Surface Microenvironment Facilitates to Chondrogenic Differentiation and Maintenance." International Journal of Molecular Sciences 21, no. 20 (2020): 7744. http://dx.doi.org/10.3390/ijms21207744.

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Osteoarthritis (OA), a disease that greatly impacts quality of life, has increasing worldwide prevalence as the population ages. However, its pathogenic mechanisms have not been fully elucidated and current therapeutic treatment strategies are inadequate. In recent years, abnormal endochondral ossification in articular cartilage has received attention as a pathophysiological mechanism in OA. Cartilage is composed of abundant extracellular matrix components, which are involved in tissue maintenance and regeneration, but how these factors affect endochondral ossification is not clear. Here, we s

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29

Uzieliene, I., G. Urbonaite, Z. Tachtamisevaite, A. Mobasheri, and E. Bernotiene. "The Potential of Menstrual Blood-Derived Mesenchymal Stem Cells for Cartilage Repair and Regeneration: Novel Aspects." Stem Cells International 2018 (December 3, 2018): 1–10. http://dx.doi.org/10.1155/2018/5748126.

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Menstrual blood is a unique body fluid that contains mesenchymal stem cells (MSCs). These cells have attracted a great deal of attention due to their exceptional advantages including easy access and frequently accessible sample source and no need for complex ethical and surgical interventions, as compared to other tissues. Menstrual blood-derived MSCs possess all the major stem cell properties and even have a greater proliferation and differentiation potential as compared to bone marrow-derived MSCs, making them a perspective tool in a further clinical practice. Although the potential of menst

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Eldridge, Suzanne E., Aida Barawi, Hui Wang, et al. "Agrin induces long-term osteochondral regeneration by supporting repair morphogenesis." Science Translational Medicine 12, no. 559 (2020): eaax9086. http://dx.doi.org/10.1126/scitranslmed.aax9086.

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Cartilage loss leads to osteoarthritis, the most common cause of disability for which there is no cure. Cartilage regeneration, therefore, is a priority in medicine. We report that agrin is a potent chondrogenic factor and that a single intraarticular administration of agrin induced long-lasting regeneration of critical-size osteochondral defects in mice, with restoration of tissue architecture and bone-cartilage interface. Agrin attracted joint resident progenitor cells to the site of injury and, through simultaneous activation of CREB and suppression of canonical WNT signaling downstream of

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Yang, Meng, Xin Yan, Fu-Zhen Yuan та ін. "MicroRNA-210-3p Promotes Chondrogenic Differentiation and Inhibits Adipogenic Differentiation Correlated with HIF-3α Signalling in Bone Marrow Mesenchymal Stem Cells". BioMed Research International 2021 (10 квітня 2021): 1–8. http://dx.doi.org/10.1155/2021/6699910.

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Cartilage injury of the knee joint is very common. Due to the limited self-healing ability of articular cartilage, osteoarthritis is very likely to occur if left untreated. Bone marrow mesenchymal stem cells (BMMSCs) are widely used in the study of cartilage injury due to their low immunity and good amplification ability, but they still have disadvantages, such as heterogeneous undifferentiated cells. MicroRNAs can regulate the chondrogenic differentiation ability of MSCs by inhibiting or promoting mRNA translation and degradation. In this research, we primarily investigated the effect of micr

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32

Xu, Liang, Hisatoshi Hanamatsu, Kentaro Homan, et al. "Alterations of Glycosphingolipid Glycans and Chondrogenic Markers during Differentiation of Human Induced Pluripotent Stem Cells into Chondrocytes." Biomolecules 10, no. 12 (2020): 1622. http://dx.doi.org/10.3390/biom10121622.

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Due to the limited intrinsic healing potential of cartilage, injury to this tissue may lead to osteoarthritis. Human induced pluripotent stem cells (iPSCs), which can be differentiated into chondrocytes, are a promising source of cells for cartilage regenerative therapy. Currently, however, the methods for evaluating chondrogenic differentiation of iPSCs are very limited; the main techniques are based on the detection of chondrogenic genes and histological analysis of the extracellular matrix. The cell surface is coated with glycocalyx, a layer of glycoconjugates including glycosphingolipids (

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Puzio, Iwona, Grzegorz Tymicki, Hanna Predka, Wiesław Śleboda, and Magdalena Sobczyńska-Wołejszo. "Role of nesfatin-1 in the metabolism of skeletal tissues." Medycyna Weterynaryjna 74, no. 1 (2018): 6045–2018. http://dx.doi.org/10.21521/mw.6045.

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NUCB2/nesfatin-1, a member of the adipokine family, is a peptide hormone with pleiotropic action. It has been found in different tissues, including cartilage and bone cells. Nesfatin-1 is produced by chondrocytes, and its synthesis increases with the degree of cell differentiation and upon stimulation by pro-inflammatory cytokines, as shown in an in vitro study. An increase in serum levels of nesfatin-1 has been observed in humans with osteoarthritis, which indicates the influence of pro-inflammatory cytokines on nesfatin-1 release. On the other hand, nesfatin-1 stimulates the synthesis of pro

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Chaly, Yury, Harry C. Blair, Sonja M. Smith, et al. "Follistatin-like protein 1 regulates chondrocyte proliferation and chondrogenic differentiation of mesenchymal stem cells." Annals of the Rheumatic Diseases 74, no. 7 (2014): 1467–73. http://dx.doi.org/10.1136/annrheumdis-2013-204822.

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ObjectivesChondrocytes, the only cells in the articular cartilage, play a pivotal role in osteoarthritis (OA) because they are responsible for maintenance of the extracellular matrix (ECM). Follistatin-like protein 1 (FSTL1) is a secreted protein found in mesenchymal stem cells (MSCs) and cartilage but whose function is unclear. FSTL1 has been shown to modify cell growth and survival. In this work, we sought to determine whether FSTL1 could regulate chondrogenesis and chondrogenic differentiation of MSCs.MethodsTo study the role of FSTL1 in chondrogenesis, we used FSTL1 knockout (KO) mice gene

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Wang, Yifan, Guangdong Chen, Jinku Yan, et al. "Upregulation of SIRT1 by Kartogenin Enhances Antioxidant Functions and Promotes Osteogenesis in Human Mesenchymal Stem Cells." Oxidative Medicine and Cellular Longevity 2018 (July 15, 2018): 1–15. http://dx.doi.org/10.1155/2018/1368142.

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Osteoarthritis is a chronic degenerative joint disease involving both articular cartilage and subchondral bone. Kartogenin (KGN) was recently identified to improve in vivo cartilage repair; however, its effect on bone formation is unknown. The aim of this study was to investigate the effect of KGN on antioxidant properties and osteogenic differentiation of bone marrow-derived mesenchymal stem cells (BM-MSCs). Human BM-MSCs were treated with KGN at concentrations ranging from 10−8 M to 10−6 M. Our results indicated that KGN improved cell proliferation and attenuated intracellular reactive oxyge

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Muttigi, Manjunatha S., Byoung Ju Kim, Bogyu Choi, Inbo Han, Hansoo Park, and Soo-Hong Lee. "Matrilin-3-Primed Adipose-Derived Mesenchymal Stromal Cell Spheroids Prevent Mesenchymal Stromal-Cell-Derived Chondrocyte Hypertrophy." International Journal of Molecular Sciences 21, no. 23 (2020): 8911. http://dx.doi.org/10.3390/ijms21238911.

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Adipose-derived mesenchymal stromal cells (Ad-MSCs) are a promising tool for articular cartilage repair and regeneration. However, the terminal hypertrophic differentiation of Ad-MSC-derived cartilage is a critical barrier during hyaline cartilage regeneration. In this study, we investigated the role of matrilin-3 in preventing Ad-MSC-derived chondrocyte hypertrophy in vitro and in an osteoarthritis (OA) destabilization of the medial meniscus (DMM) model. Methacrylated hyaluron (MAHA) (1%) was used to encapsulate and make scaffolds containing Ad-MSCs and matrilin-3. Subsequently, the encapsula

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Caterson, B., F. Mahmoodian, J. M. Sorrell, et al. "Modulation of native chondroitin sulphate structure in tissue development and in disease." Journal of Cell Science 97, no. 3 (1990): 411–17. http://dx.doi.org/10.1242/jcs.97.3.411.

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Chondroitin sulphate proteoglycans are synthesised by different tissues and cell types, and the chondroitin sulphate chains are variably sulphated. Three monoclonal antibodies 3B3, 7D4 and 6C3 that recognise different native chondroitin sulphate epitopes have been used to investigate changes in structure during embryonic tissue development in the chick and in the response of mature canine articular cartilage during experimental osteoarthritis. Strong focal expression of the epitopes was seen during development of chick bursa, which was different for the three epitopes and which changed during

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Lu, Tsai-Jung, Fang-Yao Chiu, Hsiao-Ying Chiu, Ming-Chau Chang, and Shih-Chieh Hung. "Chondrogenic Differentiation of Mesenchymal Stem Cells in Three-Dimensional Chitosan Film Culture." Cell Transplantation 26, no. 3 (2017): 417–27. http://dx.doi.org/10.3727/096368916x693464.

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Articular cartilage has a very limited capacity for self-repair, and mesenchymal stem cells (MSCs) have the potential to treat cartilage defects and osteoarthritis. However, in-depth mechanistic studies regarding their applications are required. Here we demonstrated the use of chitosan film culture for promoting chondrogenic differentiation of MSCs. We found that MSCs formed spheres 2 days after seeding on dishes coated with chitosan. When MSCs were induced in a chondrogenic induction medium on chitosan films, the size of the spheres continuously increased for up to 21 days. Alcian blue staini

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McMillan, AF, and E. Alsberg. "ID: 65: HYDROGEL MICROSPHERES FOR SPATIOTEMPORALLY CONTROLLED DELIVERY OF RNAI TO STEM CELLS FOR CHONDROGENESIS." Journal of Investigative Medicine 64, no. 4 (2016): 977.3–978. http://dx.doi.org/10.1136/jim-2016-000120.139.

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Osteoarthritis (OA) is a disease of the articular cartilage characterized by pain and functional limitations that can severely affect one's quality of life. Current treatments, including analgesics, microfracture, and autologous chondrocyte implantation, do not typically restore complete function; tissue engineering is a viable technology to meet this need in patient care. Our lab has engineered a system of self-assembling human mesenchymal stem cell sheets incorporated with growth factor-releasing hydrogel microspheres. This system of self-assembled, microsphere-incorporated stem cell sheets

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Ecke, Lutter, Scholka, Hansch, Becker, and Anderer. "Tissue Specific Differentiation of Human Chondrocytes Depends on Cell Microenvironment and Serum Selection." Cells 8, no. 8 (2019): 934. http://dx.doi.org/10.3390/cells8080934.

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Therapeutic options to cure osteoarthritis (OA) are not yet available, although cell-based therapies for the treatment of traumatic defects of cartilage have already been developed using, e.g., articular chondrocytes. In order to adapt cell-based therapies to treat OA, appropriate cell culture conditions are necessary. Chondrocytes require a 3-dimensional (3D) environment for redifferentiation after 2-dimensional (2D) expansion. Fetal bovine serum (FBS) is commonly used as a medium supplement, although the usage of a xenogeneic serum could mask the intrinsic behavior of human cells in vitro. T

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Holmes, Benjamin, Nathan J. Castro, Jian Li, and Lijie Grace Zhang. "Novel Biologically Inspired Nanostructured Scaffolds for Directing Chondrogenic Differentiation of Mesenchymal Stem Cells." MRS Proceedings 1498 (2013): 59–66. http://dx.doi.org/10.1557/opl.2013.181.

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ABSTRACTCartilage defects, which are caused by a variety of reasons such as traumatic injuries, osteoarthritis, or osteoporosis, represent common and severe clinical problems. Each year, over 6 million people visit hospitals in the U.S. for various knee, wrist, and ankle problems. As modern medicine advances, new and novel methodologies have been explored and developed in order to solve and improve current medical problems. One of the areas of investigation is tissue engineering [1, 2]. Since cartilage matrix is nanocomposite, the goal of the current work is to use nanomaterials and nanofabric

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Fu, Zhenlan, Xiongbo Song, Lin Guo, Liu Yang, and Cheng Chen. "Effects of Conditioned Medium From Osteoarthritic Cartilage Fragments on Donor-Matched Infrapatellar Fat Pad–Derived Mesenchymal Stromal Cells." American Journal of Sports Medicine 47, no. 12 (2019): 2927–36. http://dx.doi.org/10.1177/0363546519869241.

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Background: Mesenchymal stromal cell (MSC)–based therapies have emerged as a promising strategy for osteoarthritis (OA) treatment. In particular, infrapatellar fat pad (IPFP)–derived MSCs have become a good option to treat knee OA. Purpose: To investigate the influence of the local microenvironment of the knee joint, especially OA cartilage, on the bioactivities of injected/implanted IPFP MSCs. Study Design: Controlled laboratory study. Methods: Conditioned medium (CM) derived from OA cartilage fragments was collected and characterized. Donor-matched IPFP MSCs were treated with control medium

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Lo Monaco, Melissa, Pascal Gervois, Joel Beaumont, et al. "Therapeutic Potential of Dental Pulp Stem Cells and Leukocyte- and Platelet-Rich Fibrin for Osteoarthritis." Cells 9, no. 4 (2020): 980. http://dx.doi.org/10.3390/cells9040980.

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Osteoarthritis (OA) is a degenerative and inflammatory joint disorder with cartilage loss. Dental pulp stem cells (DPSCs) can undergo chondrogenic differentiation and secrete growth factors associated with tissue repair and immunomodulation. Leukocyte- and platelet-rich fibrin (L-PRF) emerges in regenerative medicine because of its growth factor content and fibrin matrix. This study evaluates the therapeutic application of DPSCs and L-PRF in OA via immunomodulation and cartilage regeneration. Chondrogenic differentiation of DPSCs, with or without L-PRF exudate (ex) and conditioned medium (CM),

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Meyer, F., M. Bollmann, U. Kornak, and J. Bertrand. "AB0067 CHONDROCALCINOSIS IS ASSOCIATED WITH A SPECIFIC EFFECT ON THE CHONDROCYTE PHENOTYPE THAT MARKEDLY DIFFERS FROM OA." Annals of the Rheumatic Diseases 79, Suppl 1 (2020): 1334.1–1334. http://dx.doi.org/10.1136/annrheumdis-2020-eular.5179.

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Background:Calcification of cartilage with BCP crystals is a common finding during osteoarthritis (OA) and is directly linked to the severity of the disease and hypertrophic differentiation of chondrocytes. Chondrocalcinosis (CC) is associated with CPPD crystal formation. There is only little knowledge about the effect of CPPD crystals on chondrocytes.Objectives:The aim of this study was to investigate the chondrocyte phenotype in CC cartilage and the effect of CPPD crystals on chondrocytes.Methods:Cartilage samples of patients with CC were used and compared with samples of severe OA patients

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Pattappa, Girish, Brian Johnstone, Johannes Zellner, Denitsa Docheva, and Peter Angele. "The Importance of Physioxia in Mesenchymal Stem Cell Chondrogenesis and the Mechanisms Controlling Its Response." International Journal of Molecular Sciences 20, no. 3 (2019): 484. http://dx.doi.org/10.3390/ijms20030484.

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Articular cartilage covers the surface of synovial joints and enables joint movement. However, it is susceptible to progressive degeneration with age that can be accelerated by either previous joint injury or meniscectomy. This degenerative disease is known as osteoarthritis (OA) and it greatly affects the adult population. Cell-based tissue engineering provides a possible solution for treating OA at its earliest stages, particularly focal cartilage lesions. A candidate cell type for treating these focal defects are Mesenchymal Stem Cells (MSCs). However, present methods for differentiating th

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Xing, Dan, Kai Wang, Jun Wu, et al. "Clinical-Grade Human Embryonic Stem Cell-Derived Mesenchymal Stromal Cells Ameliorate the Progression of Osteoarthritis in a Rat Model." Molecules 26, no. 3 (2021): 604. http://dx.doi.org/10.3390/molecules26030604.

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Mesenchymalstem cell (MSC)-based therapy is being increasingly explored in preclinical and clinical studies as a regenerative method for treating osteoarthritis (OA). However, the use of primary MSCs is hampered by a number of limitations, including donor heterogeneity and inconsistent cell quality. Here, we tested the therapeutic potential of embryonic stem cell-derived MSCs (ES-MSCs) in anOA rat model. ES-MSCs were generated and identified by morphology, trilineage differentiation and flow cytometry. Sprague Dawley rats were treated with either a single dose (106 cells/rat) of ES-MSCs or wit

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Zhao, Yifan, and Liang Xie. "An Update on Mesenchymal Stem Cell-Centered Therapies in Temporomandibular Joint Osteoarthritis." Stem Cells International 2021 (April 1, 2021): 1–15. http://dx.doi.org/10.1155/2021/6619527.

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Temporomandibular joint osteoarthritis (TMJOA) is a degenerative disease characterized by cartilage degeneration, disrupted subchondral bone remodeling, and synovitis, seriously affecting the quality of life of patients with chronic pain and functional disabilities. Current treatments for TMJOA are mainly symptomatic therapies without reliable long-term efficacy, due to the limited self-renewal capability of the condyle and the poorly elucidated pathogenesis of TMJOA. Recently, there has been increased interest in cellular therapies for osteoarthritis and TMJ regeneration. Mesenchymal stem cel

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Lach, Michał, та Wiktoria M. Suchorska. "The effect of the combination of TGF-β1 and BMP2 with high-density pellet cell culture during chondrogenic differentiation of pluripotent stem cells." Letters in Oncology Science 17, № 1 (2020): 37–46. http://dx.doi.org/10.21641/los.2020.17.1.169.

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Introduction: The osteoarthritis is a serious threat for well-developed and ageing countries. Present techniques of treatment of damaged cartilage are not sufficient. Hence, new strategies should be developed. One of the potential sources for the regeneration of cartilage is pluripotent stem cells (PSC). Aim: The development of an efficient protocol of chondrogenic differentiation using PSC. Material and methods: The human embryonic stem cell line (BG01V) was used in this study. The chondrogenic differentiation was performed using high-density pellet culture in the presence of TGF-

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Xu, Tengjing, Xinning Yu, Quanming Yang, Xiaonan Liu, Jinghua Fang, and Xuesong Dai. "Autologous Micro-Fragmented Adipose Tissue as Stem Cell-Based Natural Scaffold for Cartilage Defect Repair." Cell Transplantation 28, no. 12 (2019): 1709–20. http://dx.doi.org/10.1177/0963689719880527.

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Osteoarthritis (OA) poses a tough challenge worldwide. Adipose-derived stem cells (ASCs) have been proved to play a promising role in cartilage repair. However, enzymatic digestion, ex vivo culture and expansion, with significant senescence and decline in multipotency, limit their application. The present study was designed to obtain micro-fragmented adipose tissue (MFAT) through gentle mechanical force and determine the effect of this stem cell-based natural scaffold on repair of full-thickness cartilage defects. In this study, ASCs sprouted from MFAT were characterized by multi-differentiati

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Luo, Yi, Ai-Tong Wang, Qing-Fang Zhang, Ru-Ming Liu, and Jian-Hui Xiao. "RASL11B gene enhances hyaluronic acid-mediated chondrogenic differentiation in human amniotic mesenchymal stem cells via the activation of Sox9/ERK/smad signals." Experimental Biology and Medicine 245, no. 18 (2020): 1708–21. http://dx.doi.org/10.1177/1535370220944375.

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This study aimed to elucidate the molecular mechanisms, whereby hyaluronic acid, a main extracellular matrix component of articular cartilage, promotes the chondrogenic differentiation of human amniotic mesenchymal stem cells (hAMSCs). Our previous findings indicated that hyaluronic acid combined with hAMSCs showed a marked therapeutic effect against rat osteoarthritis. In the present study, hyaluronic acid markedly enhanced the expression of chondrocyte-specific markers including Col2α1, Acan, and Sox9 in hAMSCs, with strong synergistic effects on chondrogenic differentiation, in combination

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