Literatura académica sobre el tema "Cartilage cells – Transplantation"

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Artículos de revistas sobre el tema "Cartilage cells – Transplantation"

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Messner, K. "Articular cartilage transplantation using precultivated cells." Der Orthopäde 28, no. 1 (January 1999): 61–67. http://dx.doi.org/10.1007/pl00003551.

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Enomura, Masahiro, Soichiro Murata, Yuri Terado, Maiko Tanaka, Shinji Kobayashi, Takayoshi Oba, Shintaro Kagimoto, et al. "Development of a Method for Scaffold-Free Elastic Cartilage Creation." International Journal of Molecular Sciences 21, no. 22 (November 11, 2020): 8496. http://dx.doi.org/10.3390/ijms21228496.

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Microtia is a congenital aplasia of the auricular cartilage. Conventionally, autologous costal cartilage grafts are collected and shaped for transplantation. However, in this method, excessive invasion occurs due to limitations in the costal cartilage collection. Due to deformation over time after transplantation of the shaped graft, problems with long-term morphological maintenance exist. Additionally, the lack of elasticity with costal cartilage grafts is worth mentioning, as costal cartilage is a type of hyaline cartilage. Medical plastic materials have been transplanted as alternatives to
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Lindahl, Anders. "From gristle to chondrocyte transplantation: treatment of cartilage injuries." Philosophical Transactions of the Royal Society B: Biological Sciences 370, no. 1680 (October 19, 2015): 20140369. http://dx.doi.org/10.1098/rstb.2014.0369.

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This review addresses the progress in cartilage repair technology over the decades with an emphasis on cartilage regeneration with cell therapy. The most abundant cartilage is the hyaline cartilage that covers the surface of our joints and, due to avascularity, this tissue is unable to repair itself. The cartilage degeneration seen in osteoarthritis causes patient suffering and is a huge burden to society. The surgical approach to cartilage repair was non-existing until the 1950s when new surgical techniques emerged. The use of cultured cells for cell therapy started as experimental studies in
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Le, Hanxiang, Weiguo Xu, Xiuli Zhuang, Fei Chang, Yinan Wang, and Jianxun Ding. "Mesenchymal stem cells for cartilage regeneration." Journal of Tissue Engineering 11 (January 2020): 204173142094383. http://dx.doi.org/10.1177/2041731420943839.

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Cartilage injuries are typically caused by trauma, chronic overload, and autoimmune diseases. Owing to the avascular structure and low metabolic activities of chondrocytes, cartilage generally does not self-repair following an injury. Currently, clinical interventions for cartilage injuries include chondrocyte implantation, microfracture, and osteochondral transplantation. However, rather than restoring cartilage integrity, these methods only postpone further cartilage deterioration. Stem cell therapies, especially mesenchymal stem cell (MSCs) therapies, were found to be a feasible strategy in
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Plánka, Ladislav, David Starý, Jana Hlučilová, Jiří Klíma, Josef Jančář, Leoš Křen, Jana Lorenzová, et al. "Comparison of Preventive and Therapeutic Transplantations of Allogeneic Mesenchymal Stem Cells in Healing of the Distal Femoral Growth Plate Cartilage Defects in Miniature Pigs." Acta Veterinaria Brno 78, no. 2 (2009): 293–302. http://dx.doi.org/10.2754/avb200978020293.

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The aim of the study was to verify whether there is a difference in the lengthwise growth of the femurs and in their angular deformity when comparing preventive vs. therapeutic transplantation of allogeneic mesenchymal stem cells (MSCs) to an iatrogenic defect in the distal physis of femur. Modified composite chitosan/collagen type I scaffold with MSCs was transplanted to an iatrogenically created defect of the growth cartilage in the lateral condyle of the left femur in 20 miniature male pigs. In Group A of animals (n = 10) allogeneic MSCs were transplanted immediately after creating the defe
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Rim, Yeri Alice, Yoojun Nam, and Ji Hyeon Ju. "Application of Cord Blood and Cord Blood-Derived Induced Pluripotent Stem Cells for Cartilage Regeneration." Cell Transplantation 28, no. 5 (September 25, 2018): 529–37. http://dx.doi.org/10.1177/0963689718794864.

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Regeneration of articular cartilage is of great interest in cartilage tissue engineering since articular cartilage has a low regenerative capacity. Due to the difficulty in obtaining healthy cartilage for transplantation, there is a need to develop an alternative and effective regeneration therapy to treat degenerative or damaged joint diseases. Stem cells including various adult stem cells and pluripotent stem cells are now actively used in tissue engineering. Here, we provide an overview of the current status of cord blood cells and induced pluripotent stem cells derived from these cells in
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Bae, Jung Yoon, Kazuaki Matsumura, Shigeyuki Wakitani, Amu Kawaguchi, Sadami Tsutsumi, and Suong-Hyu Hyon. "Beneficial Storage Effects of Epigallocatechin-3-O-Gallate on the Articular Cartilage of Rabbit Osteochondral Allografts." Cell Transplantation 18, no. 5-6 (May 2009): 505–12. http://dx.doi.org/10.1177/096368970901805-604.

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A fresh osteochondral allograft is one of the most effective treatments for cartilage defects of the knee. Despite the clinical success, fresh osteochondral allografts have great limitations in relation to the short storage time that cartilage tissues can be well-preserved. Fresh osteochondral grafts are generally stored in culture medium at 4°C. While the viability of articular cartilage stored in culture medium is significantly diminished within 1 week, appropriate serology testing to minimize the chances for the disease transmission requires a minimum of 2 weeks. (–)-Epigallocatechin-3- O-g
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Moskalewski, S., and J. Malejczyk. "Bone formation following intrarenal transplantation of isolated murine chondrocytes: chondrocyte-bone cell transdifferentiation?" Development 107, no. 3 (November 1, 1989): 473–80. http://dx.doi.org/10.1242/dev.107.3.473.

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Isolated syngeneic epiphyseal chondrocytes transplanted into a muscle formed cartilage in which matrix resorption and endochondral ossification began at the end of the second week after transplantation. After 56 days cartilage was converted into an ossicle. In 7-day-old intrarenal transplants, epiphyseal chondrocytes formed nodules of cartilage. In 10-day-old transplants, islands of bone appeared. Slight resorption of cartilage was first noted in 14-day-old transplants of chondrocytes. After eight weeks, transplants contained mainly bone. Intramuscularly transplanted rib chondrocytes formed ca
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Cima, L. G., J. P. Vacanti, C. Vacanti, D. Ingber, D. Mooney, and R. Langer. "Tissue Engineering by Cell Transplantation Using Degradable Polymer Substrates." Journal of Biomechanical Engineering 113, no. 2 (May 1, 1991): 143–51. http://dx.doi.org/10.1115/1.2891228.

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This paper reviews our research in developing novel matrices for cell transplantation using bioresorbable polymers. We focus on applications to liver and cartilage as paradigms for regeneration of metabolic and structural tissue, but review the approach in the context of cell transplantation as a whole. Important engineering issues in the design of successful devices are the surface chemistry and surface microstructure, which influence the ability of the cells to attach, grow, and function normally; the porosity and macroscopic dimensions, which affect the transport of nutrients to the implant
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Longo, Umile Giuseppe, Stefano Petrillo, Edoardo Franceschetti, Alessandra Berton, Nicola Maffulli, and Vincenzo Denaro. "Stem Cells and Gene Therapy for Cartilage Repair." Stem Cells International 2012 (2012): 1–9. http://dx.doi.org/10.1155/2012/168385.

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Cartilage defects represent a common problem in orthopaedic practice. Predisposing factors include traumas, inflammatory conditions, and biomechanics alterations. Conservative management of cartilage defects often fails, and patients with this lesions may need surgical intervention. Several treatment strategies have been proposed, although only surgery has been proved to be predictably effective. Usually, in focal cartilage defects without a stable fibrocartilaginous repair tissue formed, surgeons try to promote a natural fibrocartilaginous response by using marrow stimulating techniques, such
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Tesis sobre el tema "Cartilage cells – Transplantation"

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Jones, Christopher Wynne. "Laser scanning confocal arthroscopy in orthopaedics : examination of chondrial and connective tissues, quantification of chondrocyte morphology, investigation of matirx-induced autologous chondrocyte implantation and characterisation of osteoarthritis." University of Western Australia. School of Mechanical Engineering, 2007. http://theses.library.uwa.edu.au/adt-WU2008.0061.

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[Truncated abstract] Articular cartilage (AC) covers the surface of synovial joints providing a nearly frictionless bearing surface and distributing mechanical load. Joint trauma can damage the articular surface causing pain, loss of mobility and deformation. Currently there is no uniform treatment protocol for managing focal cartilage defects, with most treatment options targeted towards symptomatic relief but not limiting the progression into osteoarthritis (OA). Autologous chondrocyte implantation (ACI) and more recently matrix-induced autologous chondrocyte implantation (MACI), have emerge
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Rakic, Rodolphe. "Nouvelles stratégies thérapeutiques des affections articulaires du cheval : évaluation du potentiel thérapeutique des chondrocytes autologues et des cellules souches de cordon ombilical (sang et gelée de Wharton) : vers l'industrialisation de cellules médicaments." Thesis, Normandie, 2017. http://www.theses.fr/2017NORMC406/document.

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Les affections articulaires touchant le cartilage, telles que les lésions focales et l’arthrose, correspondent aux principales causes de baisse de performance et d’arrêt prématuré de la carrière sportive du cheval. Ainsi, le traitement des affections du cartilage représente un enjeu vétérinaire majeur dans le monde équin, du fait des importantes pertes financières qu’elles occasionnent à la filière. Les faibles capacités de réparation intrinsèque du cartilage, ainsi que l’absence de thérapie à long terme des dommages cartilagineux, nécessitent le recours à des thérapies de nouvelles génération
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Aulin, Cecilia. "Extracellular Matrix Based Materials for Tissue Engineering." Doctoral thesis, Uppsala universitet, Institutionen för materialkemi, 2010. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-110631.

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The extracellular matrix is (ECM) is a network of large, structural proteins and polysaccharides, important for cellular behavior, tissue development and maintenance. Present thesis describes work exploring ECM as scaffolds for tissue engineering by manipulating cells cultured in vitro or by influencing ECM expression in vivo. By culturing cells on polymer meshes under dynamic culture conditions, deposition of a complex ECM could be achieved, but with low yields. Since the major part of synthesized ECM diffused into the medium the rate limiting step of deposition was investigated. This quantit
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"Effect of scaffold-free bioengineered chondrocyte pellet in osteochondral defect in a rabbit model." 2009. http://library.cuhk.edu.hk/record=b5893862.

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Cheuk, Yau Chuk.<br>Thesis submitted in: Dec 2008.<br>Thesis (M.Phil.)--Chinese University of Hong Kong, 2009.<br>Includes bibliographical references (leaves 132-144).<br>Abstracts in English and Chinese.<br>ABSTRACT --- p.i<br>論文摘要 --- p.iii<br>PUBLICATIONS --- p.v<br>ACKNOWLEDGEMENT --- p.vi<br>LIST OF ABBREBIVIATIONS --- p.vii<br>INDEX FOR FIGURES --- p.x<br>INDEX FOR TABLES --- p.xiv<br>TABLE OF CONTENTS --- p.xv<br>Chapter CHAPTER ONE - --- INTRODUCTION<br>Chapter 1.1 --- "Joint function, structure and biochemistry"<br>Chapter 1.1.1 --- Function of joint --- p.1<br>Chapter 1.1.2
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Lavoie, Jean-Francois. "Mesodermal Differentiation of Skin-derived Precursor cells." Thesis, 2010. http://hdl.handle.net/1807/24807.

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Neural crest stem cells (NCSCs) are embryonic multipotent cells that give rise to a wide range of cell types that include those forming the peripheral neural cells and the mesodermal cells of the face including the facial bones. In neonatal and adult skin, skin-derived precursor cells (SKPs) are multipotent dermal precursors that share similarities with NCSCs and can differentiate into peripheral neural and mesodermal cells, such as adipocytes. Based on the similarities between SKPs and NCSCs, I asked, in this thesis, whether rodent or human SKPs can differentiate into skeletal mesodermal ce
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Libros sobre el tema "Cartilage cells – Transplantation"

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Khan, Wasim S. Stem cells and cartilage tissue engineering approaches to orthopaedic surgery. Hauppauge, N.Y: Nova Science Publishers, 2009.

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Jūryūshi Ikagaku Sentā. Shinpojūmu "Saisei Iryō to Bunshi Imējingu." Dai 3-kai Jūryūshi Ikagaku Sentā Shinpojūmu Saisei Iryō to Bunshi Imējingu. Chiba-ken Chiba-shi: Hōshasen Igaku Sōgō Kenkyūjo, 2004.

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(Foreword), L. Peterson, B. J. Cole (Foreword), and Riley J. Williams (Editor), eds. Cartilage Repair Strategies. Humana Press, 2007.

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Douglas, Kenneth. Bioprinting. Oxford University Press, 2021. http://dx.doi.org/10.1093/oso/9780190943547.001.0001.

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Abstract: This book describes how bioprinting emerged from 3D printing and details the accomplishments and challenges in bioprinting tissues of cartilage, skin, bone, muscle, neuromuscular junctions, liver, heart, lung, and kidney. It explains how scientists are attempting to provide these bioprinted tissues with a blood supply and the ability to carry nerve signals so that the tissues might be used for transplantation into persons with diseased or damaged organs. The book presents all the common terms in the bioprinting field and clarifies their meaning using plain language. Readers will lear
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Capítulos de libros sobre el tema "Cartilage cells – Transplantation"

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Karnatzikos, Georgios, Sotirios Vlachoudis, and Alberto Gobbi. "Rehabilitation After Knee Cartilage Transplantation with Autologous Chondrocytes or Stem Cells." In Sports Injuries, 1905–12. Berlin, Heidelberg: Springer Berlin Heidelberg, 2015. http://dx.doi.org/10.1007/978-3-642-36569-0_265.

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Karnatzikos, Georgios, Sotirios Vlachoudis, and Alberto Gobbi. "Rehabilitation After Knee Cartilage Transplantation with Autologous Chondrocytes or Stem Cells." In Sports Injuries, 1–9. Berlin, Heidelberg: Springer Berlin Heidelberg, 2014. http://dx.doi.org/10.1007/978-3-642-36801-1_265-1.

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Peterson, Lars. "Cartilage Cell Transplantation." In Knee Surgery, 440–49. Berlin, Heidelberg: Springer Berlin Heidelberg, 2001. http://dx.doi.org/10.1007/978-3-642-87202-0_33.

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Tomford, William W., and Henry J. Mankin. "Bone and cartilage transplantation." In Yearbook of Cell and Tissue Transplantation 1996–1997, 37–40. Dordrecht: Springer Netherlands, 1996. http://dx.doi.org/10.1007/978-94-009-0165-0_4.

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Ibarra, Clemente, Robert Langer, and Joseph P. Vacanti. "Tissue engineering: Cartilage, bone and muscle." In Yearbook of Cell and Tissue Transplantation 1996–1997, 235–45. Dordrecht: Springer Netherlands, 1996. http://dx.doi.org/10.1007/978-94-009-0165-0_23.

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Saltzman, W. Mark. "The State-of-the-Art in Tissue Exchange." In Tissue Engineering. Oxford University Press, 2004. http://dx.doi.org/10.1093/oso/9780195141306.003.0005.

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It is an impressive spectacle. Multicellular organisms—from fruitflies to humans—emerge from a single cell through a coordinated sequence of cell division, movement, and specialization. Many of the fundamental mechanisms of animal development are known: differentiated cells arise from less specialized precursor or stem cells, cells organize into functional units by migration and selective adhesion, and cell-secreted growth factors stimulate growth or differentiation in other cells. Despite extensive progress in acquiring basic knowledge, however, therapeutic opportunities for patients with tissue loss due to trauma or disease remain extremely limited. Degeneration within the nervous system can reduce the quality and length of life for individuals with Parkinson’s disease. Inadequate healing can cause various problems, including liver failure after hepatitis infections, as well as chronic pain from venous leg ulcers and severe infections in burn victims. The symphony of development is difficult to conduct in adults. Tissue or whole-organ transplantation is one of the few options currently available for patients with many common ailments including excessive skin loss and artery occlusion. During the past century, many of the obstacles to transplantation were cleared: immunosuppressive drugs and advanced surgical techniques make liver, heart, kidney, blood vessel, and other major organ transplantations a daily reality. But transplantation technology has encountered another severe limitation. The number of patients requiring a transplant far exceeds the available supply of donor tissues. New technology is needed to reduce this deficit. Some advances will come from individuals trained to synthesize basic scientific discoveries (for example, in developmental biology) with modern bioengineering principles. Tissue engineering grew from the challenge presented by tissue shortage. Tissue engineers are working to develop new approaches for encouraging tissue growth and repair; these approaches are founded on basic science of organ development and wound healing. A few pioneering efforts are already being tested in patients; these include engineered skin equivalents for wound repair, transplanted cells that are isolated from the immune system by encapsulation in polymer membranes for treatment of diabetes, and chondrocyte implantation for repair of articular cartilage defects.
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Douglas, Kenneth. "Introduction." In Bioprinting, 1–2. Oxford University Press, 2021. http://dx.doi.org/10.1093/oso/9780190943547.003.0001.

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Abstract: Bioprinting: To Make Ourselves Anew describes how bioprinting emerged from 3D printing and details the accomplishments and challenges in bioprinting tissues of cartilage, skin, bone, muscle, neuromuscular junctions, liver, heart, lung, and kidney. It explains how scientists are attempting to provide these bioprinted tissues with a blood supply and the ability to carry nerve signals so that the tissues might be used for transplantation into persons with diseased or damaged organs. The book presents all the common terms in the bioprinting field and clarifies their meaning using plain language. The reader will learn about bioink—a bioprinting material containing living cells and supportive biomaterials. Additionally, readers will become at ease with concepts such as fugitive inks (sacrificial inks used to make channels for blood flow), extracellular matrices (the biological environment surrounding cells), decellularization (the process of isolating cells from their native environment), hydrogels (water-based substances that can substitute for the extracellular matrix), rheology (the flow properties of a bioink), bioreactors (containers to provide the environment cells need to thrive and multiply). Further vocabulary that will become familiar includes diffusion (passive movement of oxygen and nutrients from regions of high concentration to regions of low concentration), stem cells (cells with the potential to develop into different bodily cell types), progenitor cells (early descendants of stem cells), gene expression (the process by which proteins develop from instructions in our DNA), and growth factors (substances—often proteins—that stimulate cell growth, proliferation, and differentiation). The book contains an extensive glossary for quick reference.
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Saltzman, W. Mark. "Delivery of Molecular Agents in Tissue Engineering." In Tissue Engineering. Oxford University Press, 2004. http://dx.doi.org/10.1093/oso/9780195141306.003.0017.

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The previous chapter provided some examples of tissue engineering, in which cells that were isolated and engineered outside of the body are introduced into a patient by direct injection of a cell suspension, typically into the circulatory system. But the field of tissue engineering also points to treatments that are conceptually different from variations on cell transfusion technology; tissue engineering promises the regrowth of adult tissue structure through application of engineered cells and synthetic materials. In support of this broad claim, the field of tissue engineering can point to some initial successes. For example, synthetic materials are now available that accelerate healing of burns and skin ulcers. In addition, in vitro cell culture methods now allow the amplification of a patient’s own cells for cartilage repair or bone marrow transplantation. But major obstacles to the widespread application of tissue engineering remain. Tissue engineers have not yet learned how to reproduce complex tissue architectures, such as vascular networks, which are essential for the normal function of many tissues. In fact, the tissue engineering concepts that have been demonstrated in the laboratory to date involve arrangements of cells and materials into precursor tissues (or neotissues) that develop according to natural processes that are already present within the cells or the materials at the time of implantation. These methods may be suitable for production of some tissues in which either the structure is relatively homogeneous (such as cartilage, in which a tissue structure can reform after the implantation of chondrocytes into a tissue defect) or the structure develops naturally (such as in some tissue-engineered skin, in which the stratified epithelium develops naturally by culturing at an air–liquid interface). The engineering of many tissue structures—such as the branching architectures found in many tissues or the intricate network architecture of the nervous system—will probably require methods for introducing and changing molecular signals during the process of neo-tissue development. For example, it is well known that chemical gradients of factors known as morphogens induce the formation of structures during development; some of the attributes of morphogens were introduced in Chapter 3.
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Mendelson, Avital, Chang Hun Lee, and Jeremy J. Mao. "CARTILAGE REGENERATION WITH AND WITHOUT CELL TRANSPLANTATION." In Stem Cell Bioengineering and Tissue Engineering Microenvironment, 339–53. WORLD SCIENTIFIC, 2011. http://dx.doi.org/10.1142/9789812837899_0012.

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Actas de conferencias sobre el tema "Cartilage cells – Transplantation"

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Bian, Liming, Robert L. Mauck, and Jason A. Burdick. "Dynamic Compressive Loading and Crosslinking Density Influence the Chondrogenic and Hypertrophic Differentiation of Human Mesenchymal Stem Cells Seeded in Hyaluronic Acid Hydrogels." In ASME 2012 Summer Bioengineering Conference. American Society of Mechanical Engineers, 2012. http://dx.doi.org/10.1115/sbc2012-80048.

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While hyaluronic acid (HA) hydrogels provide a stable 3D environment that is conducive to the chondrogenesis of mesenchymal stem cells (MSCs) in the presence of growth factors [1], the neocartilage that is formed remains inferior to native tissue, even after long culture durations. Additionally, MSCs eventually transit into a hypertrophic phenotype after chondrogenic induction, resulting in the calcification of the ECM after ectopic transplantation [2]. From a material design perspective, variation in the HA hydrogel scaffold crosslinking density via changes in the HA macromer concentration ca
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