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Artículos de revistas sobre el tema "Cartilage cells – Transplantation"

Autor: Grafiati
Publicado: 4 de junio de 2021
Última modificación: 15 de febrero de 2022

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1

Messner, K. "Articular cartilage transplantation using precultivated cells." Der Orthopäde 28, no. 1 (January 1999): 61–67. http://dx.doi.org/10.1007/pl00003551.

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2

Enomura, Masahiro, Soichiro Murata, Yuri Terado, Maiko Tanaka, Shinji Kobayashi, Takayoshi Oba, Shintaro Kagimoto, et al. "Development of a Method for Scaffold-Free Elastic Cartilage Creation." International Journal of Molecular Sciences 21, no. 22 (November 11, 2020): 8496. http://dx.doi.org/10.3390/ijms21228496.

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Microtia is a congenital aplasia of the auricular cartilage. Conventionally, autologous costal cartilage grafts are collected and shaped for transplantation. However, in this method, excessive invasion occurs due to limitations in the costal cartilage collection. Due to deformation over time after transplantation of the shaped graft, problems with long-term morphological maintenance exist. Additionally, the lack of elasticity with costal cartilage grafts is worth mentioning, as costal cartilage is a type of hyaline cartilage. Medical plastic materials have been transplanted as alternatives to
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3

Lindahl, Anders. "From gristle to chondrocyte transplantation: treatment of cartilage injuries." Philosophical Transactions of the Royal Society B: Biological Sciences 370, no. 1680 (October 19, 2015): 20140369. http://dx.doi.org/10.1098/rstb.2014.0369.

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This review addresses the progress in cartilage repair technology over the decades with an emphasis on cartilage regeneration with cell therapy. The most abundant cartilage is the hyaline cartilage that covers the surface of our joints and, due to avascularity, this tissue is unable to repair itself. The cartilage degeneration seen in osteoarthritis causes patient suffering and is a huge burden to society. The surgical approach to cartilage repair was non-existing until the 1950s when new surgical techniques emerged. The use of cultured cells for cell therapy started as experimental studies in
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4

Le, Hanxiang, Weiguo Xu, Xiuli Zhuang, Fei Chang, Yinan Wang, and Jianxun Ding. "Mesenchymal stem cells for cartilage regeneration." Journal of Tissue Engineering 11 (January 2020): 204173142094383. http://dx.doi.org/10.1177/2041731420943839.

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Cartilage injuries are typically caused by trauma, chronic overload, and autoimmune diseases. Owing to the avascular structure and low metabolic activities of chondrocytes, cartilage generally does not self-repair following an injury. Currently, clinical interventions for cartilage injuries include chondrocyte implantation, microfracture, and osteochondral transplantation. However, rather than restoring cartilage integrity, these methods only postpone further cartilage deterioration. Stem cell therapies, especially mesenchymal stem cell (MSCs) therapies, were found to be a feasible strategy in
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5

Plánka, Ladislav, David Starý, Jana Hlučilová, Jiří Klíma, Josef Jančář, Leoš Křen, Jana Lorenzová, et al. "Comparison of Preventive and Therapeutic Transplantations of Allogeneic Mesenchymal Stem Cells in Healing of the Distal Femoral Growth Plate Cartilage Defects in Miniature Pigs." Acta Veterinaria Brno 78, no. 2 (2009): 293–302. http://dx.doi.org/10.2754/avb200978020293.

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The aim of the study was to verify whether there is a difference in the lengthwise growth of the femurs and in their angular deformity when comparing preventive vs. therapeutic transplantation of allogeneic mesenchymal stem cells (MSCs) to an iatrogenic defect in the distal physis of femur. Modified composite chitosan/collagen type I scaffold with MSCs was transplanted to an iatrogenically created defect of the growth cartilage in the lateral condyle of the left femur in 20 miniature male pigs. In Group A of animals (n = 10) allogeneic MSCs were transplanted immediately after creating the defe
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6

Rim, Yeri Alice, Yoojun Nam, and Ji Hyeon Ju. "Application of Cord Blood and Cord Blood-Derived Induced Pluripotent Stem Cells for Cartilage Regeneration." Cell Transplantation 28, no. 5 (September 25, 2018): 529–37. http://dx.doi.org/10.1177/0963689718794864.

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Regeneration of articular cartilage is of great interest in cartilage tissue engineering since articular cartilage has a low regenerative capacity. Due to the difficulty in obtaining healthy cartilage for transplantation, there is a need to develop an alternative and effective regeneration therapy to treat degenerative or damaged joint diseases. Stem cells including various adult stem cells and pluripotent stem cells are now actively used in tissue engineering. Here, we provide an overview of the current status of cord blood cells and induced pluripotent stem cells derived from these cells in
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7

Bae, Jung Yoon, Kazuaki Matsumura, Shigeyuki Wakitani, Amu Kawaguchi, Sadami Tsutsumi, and Suong-Hyu Hyon. "Beneficial Storage Effects of Epigallocatechin-3-O-Gallate on the Articular Cartilage of Rabbit Osteochondral Allografts." Cell Transplantation 18, no. 5-6 (May 2009): 505–12. http://dx.doi.org/10.1177/096368970901805-604.

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A fresh osteochondral allograft is one of the most effective treatments for cartilage defects of the knee. Despite the clinical success, fresh osteochondral allografts have great limitations in relation to the short storage time that cartilage tissues can be well-preserved. Fresh osteochondral grafts are generally stored in culture medium at 4°C. While the viability of articular cartilage stored in culture medium is significantly diminished within 1 week, appropriate serology testing to minimize the chances for the disease transmission requires a minimum of 2 weeks. (–)-Epigallocatechin-3- O-g
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8

Moskalewski, S., and J. Malejczyk. "Bone formation following intrarenal transplantation of isolated murine chondrocytes: chondrocyte-bone cell transdifferentiation?" Development 107, no. 3 (November 1, 1989): 473–80. http://dx.doi.org/10.1242/dev.107.3.473.

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Isolated syngeneic epiphyseal chondrocytes transplanted into a muscle formed cartilage in which matrix resorption and endochondral ossification began at the end of the second week after transplantation. After 56 days cartilage was converted into an ossicle. In 7-day-old intrarenal transplants, epiphyseal chondrocytes formed nodules of cartilage. In 10-day-old transplants, islands of bone appeared. Slight resorption of cartilage was first noted in 14-day-old transplants of chondrocytes. After eight weeks, transplants contained mainly bone. Intramuscularly transplanted rib chondrocytes formed ca
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9

Cima, L. G., J. P. Vacanti, C. Vacanti, D. Ingber, D. Mooney, and R. Langer. "Tissue Engineering by Cell Transplantation Using Degradable Polymer Substrates." Journal of Biomechanical Engineering 113, no. 2 (May 1, 1991): 143–51. http://dx.doi.org/10.1115/1.2891228.

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This paper reviews our research in developing novel matrices for cell transplantation using bioresorbable polymers. We focus on applications to liver and cartilage as paradigms for regeneration of metabolic and structural tissue, but review the approach in the context of cell transplantation as a whole. Important engineering issues in the design of successful devices are the surface chemistry and surface microstructure, which influence the ability of the cells to attach, grow, and function normally; the porosity and macroscopic dimensions, which affect the transport of nutrients to the implant
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10

Longo, Umile Giuseppe, Stefano Petrillo, Edoardo Franceschetti, Alessandra Berton, Nicola Maffulli, and Vincenzo Denaro. "Stem Cells and Gene Therapy for Cartilage Repair." Stem Cells International 2012 (2012): 1–9. http://dx.doi.org/10.1155/2012/168385.

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Cartilage defects represent a common problem in orthopaedic practice. Predisposing factors include traumas, inflammatory conditions, and biomechanics alterations. Conservative management of cartilage defects often fails, and patients with this lesions may need surgical intervention. Several treatment strategies have been proposed, although only surgery has been proved to be predictably effective. Usually, in focal cartilage defects without a stable fibrocartilaginous repair tissue formed, surgeons try to promote a natural fibrocartilaginous response by using marrow stimulating techniques, such
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11

Yang, Guihua, Jiashen Shao, Jiachen Lin, Haixia Yang, Jing Jin, Chenxi Yu, Bo Shen, et al. "Transplantation of Human Umbilical Cord Blood-Derived Mesenchymal Stem Cells Improves Cartilage Repair in a Rabbit Model." BioMed Research International 2021 (February 25, 2021): 1–8. http://dx.doi.org/10.1155/2021/6380141.

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The aim of this study was to investigate the therapeutic efficacy and safety of transplanting human umbilical cord blood-derived mesenchymal stem cells (hUCB-MSCs) in the treatment of cartilage injury. First, the articular cartilage defect model in rabbits was constructed. Then, the identified hUCB-MSCs and rabbit bone marrow stem cells (rBM-MSCs) were transplanted into the bone defect, respectively, and the cartilage repair effect was observed by hematoxylin-eosin (HE) staining and immunohistochemistry. Besides, the glycosaminoglycan (GAG) content and biomechanics of the restoration area were
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12

Dang, Luong Huu, Yuan Tseng, How Tseng, and Shih-Han Hung. "Partial Decellularization for Segmental Tracheal Scaffold Tissue Engineering: A Preliminary Study in Rabbits." Biomolecules 11, no. 6 (June 10, 2021): 866. http://dx.doi.org/10.3390/biom11060866.

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In this study, we developed a new procedure for the rapid partial decellularization of the harvested trachea. Partial decellularization was performed using a combination of detergent and sonication to completely remove the epithelial layers outside of the cartilage ring. The post-decellularized tracheal segments were assessed with vital staining, which showed that the core cartilage cells remarkably remained intact while the cells outside of the cartilage were no longer viable. The ability of the decellularized tracheal segments to evade immune rejection was evaluated through heterotopic impla
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13

Silva, Laís Meireles Costa, Mariá Andrade de Carvalho Rocha, Marllos Henrique Vieira Nunes, Brenda Lurian do Nascimento Medeiros, Yulla Klinger de Carvalho Leite, Huanna Waleska Soares Rodrigues, Marcelo Campos Rodrigues, Hermínio José da Rocha Neto, Maria Acelina Martins de Carvalho, and Napoleão Martins Argôlo Neto. "Xenogeneic Mesenchymal Stem Cells in the Formation of Hyaline Cartilage in Osteochondral Goat Failure." Acta Scientiae Veterinariae 46, no. 1 (May 16, 2018): 10. http://dx.doi.org/10.22456/1679-9216.82560.

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Background: Osteochondral knee failures are among the most common causes of disability among the elderly human population and animal athletes. The xenogeneic transplantation of mesenchymal stem cells is a questionable therapeutic alternative that, despite the low expression of Major Histocompatibility Complex type II by these cells, still has relevantuncertainties about the safety and clinical efficacy. The main objective of the present study was to investigate whether the xenogeneic transplantation of mesenchymal stem cells induces hyaline cartilage formation, without histopathological eviden
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14

Thorp, Hallie, Kyungsook Kim, Makoto Kondo, Travis Maak, David W. Grainger, and Teruo Okano. "Trends in Articular Cartilage Tissue Engineering: 3D Mesenchymal Stem Cell Sheets as Candidates for Engineered Hyaline-Like Cartilage." Cells 10, no. 3 (March 13, 2021): 643. http://dx.doi.org/10.3390/cells10030643.

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Articular cartilage defects represent an inciting factor for future osteoarthritis (OA) and degenerative joint disease progression. Despite multiple clinically available therapies that succeed in providing short term pain reduction and restoration of limited mobility, current treatments do not reliably regenerate native hyaline cartilage or halt cartilage degeneration at these defect sites. Novel therapeutics aimed at addressing limitations of current clinical cartilage regeneration therapies increasingly focus on allogeneic cells, specifically mesenchymal stem cells (MSCs), as potent, banked,
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15

Chailakhyan, R. K., A. B. Shekhter, V. I. Tel’pukhov, S. V. Ivannikov, Yu V. Gerasimov, N. N. Vorobieva, I. L. Moskvina, and V. N. Bagratashvili. "Repair of Partial Thickness Articular Hyaline Cartilage Injuries with Multipotent Mesenchymal Stromal Bone Marrow Cells Transplantation in Rabbits." N.N. Priorov Journal of Traumatology and Orthopedics 22, no. 1 (March 15, 2015): 23–27. http://dx.doi.org/10.17816/vto201522123-27.

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Possibility of hyaline cartilage integrity restoration using multipotent mesenchymal stromal cells (MMSC) was studied on the rabbit model of partial thickness articular hyaline cartilage defect without subchondral plate damage. Size of defect made up 0.5 cm in diameter and 1.5 mm deep. Autologous bone marrow was harvested from the resected upper flaring portion of the ilium, single cell suspension was prepared and cultured in matrasses. Grown MMSC were centrifuged and the sediment was transferred into the cartilage defect. The cells were covered with either vicryl or gelatin sponge, or vicryl
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16

Chailakhyan, R. K., A. B. Shekhter, V. I. Tel’Pukhov, S. V. Ivannikov, Yu V. Gerasimov, N. N. Vorobieva, I. L. Moskvina, and V. N. Bagratashvili. "Repair of Partial Thickness Articular Hyaline Cartilage Injuries with Multipotent Mesenchymal Stromal Bone Marrow Cells Transplantation in Rabbits." Vestnik travmatologii i ortopedii imeni N.N. Priorova, no. 1 (March 30, 2015): 23–27. http://dx.doi.org/10.32414/0869-8678-2015-1-23-27.

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Possibility of hyaline cartilage integrity restoration using multipotent mesenchymal stromal cells (MMSC) was studied on the rabbit model of partial thickness articular hyaline cartilage defect without subchondral plate damage. Size of defect made up 0.5 cm in diameter and 1.5 mm deep. Autologous bone marrow was harvested from the resected upper flaring portion of the ilium, single cell suspension was prepared and cultured in matrasses. Grown MMSC were centrifuged and the sediment was transferred into the cartilage defect. The cells were covered with either vicryl or gelatin sponge, or vicryl
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17

Li, Bing Hui, Yong Yu, and Dan Xu. "The Application of Tissue Engineering Cartilage and Bracket Constructed Biomaterials for Athletic Injury." Advanced Materials Research 643 (January 2013): 68–71. http://dx.doi.org/10.4028/www.scientific.net/amr.643.68.

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The development of tissue engineering techniques for cartilage repair and regeneration provided a new way, according to their own characteristics and structure of the cartilage, as artificial cartilage replacement materials and scaffold materials should have good biomechanical properties. The effect of autologous cartilage transplantation is best in the field of articular cartilage repair, the study of bone marrow stromal cells in vitro tests and animal experiments was more, and the clinical application was less, which is still in the stage of exploration. Biomaterials material for tissue repa
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18

Plánka, L., A. Nečas, P. Gál, H. Kecová, E. Filová, L. Křen, and P. Krupa. "Prevention of Bone Bridge Formation Using Transplantation of the Autogenous Mesenchymal Stem Cells to Physeal Defects: An Experimental Study in Rabbits." Acta Veterinaria Brno 76, no. 2 (2007): 253–63. http://dx.doi.org/10.2754/avb200776020253.

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Physeal cartilage is known to have poor self-repair capacity after injury. Evaluation of the ability of cultured mesenchymal stem cells to repair damaged physis is the topic of current research. In 10 immature New Zealand white rabbits autogenous mesenchymal stem cells were transplanted into a iatrogenic physeal defect in a lateral portion of the distal growth plate of the right femur. The same defect without stem cells transplantation in the left femoral distal physis served as a control. In our study, we used our own technique of implantation of MSCs with a newly modified gel scaffold (New C
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19

Wang, Qian, Na Yang, Kun Zhang, Zhong Li, Yangjun Zhu, and Zhe Song. "Effect of intra-articular injection of adipose stem cells on traumatic osteoarthritis cartilage defects." Materials Express 11, no. 1 (January 1, 2021): 28–37. http://dx.doi.org/10.1166/mex.2021.1874.

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Traumatic osteoarthritis with cartilage defects can lead to mobility problems. Mitotic activity in cartilage is extremely low, and once damaged, repairing can be difficult. The commonly used autologous or allogeneic cartilage transplantation techniques also have certain limitations. In recent years, directed induction of osteoblastic differentiation using adipocytes has been shown to be effective in repairing cartilage defects. However, it is often induced in vitro and is prone to incomplete or over-differentiation. In addition, because of the large differences in the in vivo and in vitro micr
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20

Muñoz-Criado, Ignacio, Jose Meseguer-Ripolles, Maravillas Mellado-López, Ana Alastrue-Agudo, Richard J. Griffeth, Jerónimo Forteza-Vila, Ramón Cugat, Montserrat García, and Victoria Moreno-Manzano. "Human Suprapatellar Fat Pad-Derived Mesenchymal Stem Cells Induce Chondrogenesis and Cartilage Repair in a Model of Severe Osteoarthritis." Stem Cells International 2017 (2017): 1–12. http://dx.doi.org/10.1155/2017/4758930.

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Cartilage degeneration is associated with degenerative bone and joint processes in severe osteoarthritis (OA). Spontaneous cartilage regeneration is extremely limited. Often the treatment consists of a partial or complete joint implant. Adipose-derived stem cell (ASC) transplantation has been shown to restore degenerated cartilage; however, regenerative differences of ASC would depend on the source of adipose tissue. The infra- and suprapatellar fat pads surrounding the knee offer a potential autologous source of ASC for patients after complete joint substitution. When infrapatellar- and supra
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21

Ba, Kai, Xueqin Wei, Duan Ni, Na Li, Tianfeng Du, Xinbo Wang, and Wenting Pan. "Chondrocyte Co-cultures with the Stromal Vascular Fraction of Adipose Tissue in Polyhydroxybutyrate/Poly-(hydroxybutyrate-co-hydroxyhexanoate) Scaffolds: Evaluation of Cartilage Repair in Rabbit." Cell Transplantation 28, no. 11 (July 24, 2019): 1432–38. http://dx.doi.org/10.1177/0963689719861275.

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Chondral defects are challenging to repair because of the poor self-healing capacity of articular cartilage. The aim of this study was to compare and investigate the cartilage regeneration of stromal vascular fraction (SVF) cells and adipose-derived stem cells (ASCs) co-cultured with chondrocytes seeding on scaffolds composed of polyhydroxybutyrate (PHB)/poly-(hydroxybutyrate-co-hydroxyhexanoate) (PHBHHx). In this study, the cellular morphologies and proliferation capabilities on scaffolds were evaluated. Next, scaffolds with 1:1 co-culture of ASCs/SVF and chondrocytes were implanted into the
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22

Oshima, Yasushi, Nobuyoshi Watanabe, Ken-ichi Matsuda, Shinro Takai, Mitsuhiro Kawata, and Toshikazu Kubo. "Behavior of Transplanted Bone Marrow-derived GFP Mesenchymal Cells in Osteochondral Defect as a Simulation of Autologous Transplantation." Journal of Histochemistry & Cytochemistry 53, no. 2 (February 2005): 207–16. http://dx.doi.org/10.1369/jhc.4a6280.2005.

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To elucidate the behavior of autologously transplanted mesenchymal cells in osteochondral defects, we followed transplanted cells using green fluorescent protein (GFP) transgenic rats, in which all cells express GFP signals in their cytoplasm and nuclei as transplantation donors. Bone marrow-derived mesenchymal cells, which contain mesenchymal stem cells (MSCs), were obtained from transgenic rats. Then, dense mesenchymal cell masses created by hanging-drop culture were transplanted and fixed with fibrin glue into osteochondral defects of wild-type rats. At 24 weeks after surgery, the defects w
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23

Kondo, Shimpei, Yusuke Nakagawa, Mitsuru Mizuno, Kenta Katagiri, Kunikazu Tsuji, Shinji Kiuchi, Hideo Ono, Takeshi Muneta, Hideyuki Koga, and Ichiro Sekiya. "Transplantation of Aggregates of Autologous Synovial Mesenchymal Stem Cells for Treatment of Cartilage Defects in the Femoral Condyle and the Femoral Groove in Microminipigs." American Journal of Sports Medicine 47, no. 10 (July 15, 2019): 2338–47. http://dx.doi.org/10.1177/0363546519859855.

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Background: Previous work has demonstrated that patients with cartilage defects of the knee benefit from arthroscopic transplantation of autologous synovial mesenchymal stem cells (MSCs) in terms of magnetic resonance imaging (MRI), qualitative histologic findings, and Lysholm score. However, the effectiveness was limited by the number of cells obtained, so large-sized defects (>500 mm2) were not investigated. The use of MSC aggregates may enable treatment of larger defects by increasing the number of MSCs adhering to the cartilage defect. Purpose: To investigate whether transplantation of
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24

Nguyen, Phuc Dang-Ngoc, Ngoc Bich Vu, Ha Thi-Ngan Le, Thuy Thi-Thanh Dao, Long Xuan Gia та Phuc Van Pham. "Engineered cartilage tissue from biodegradable Poly(ε-caprolactone) scaffold and human umbilical cord derived mesenchymal stem cells". Biomedical Research and Therapy 5, № 02 (26 лютого 2018): 2000–2012. http://dx.doi.org/10.15419/bmrat.v5i02.414.

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Introduction: Cartilage injury is the most common injury among orthopedic diseases. The predominant treatment for this condition is cartilage transplantation. Therefore, production of cartilage for treatment is an important strategy in regenerative medicine of cartilage to provide surgeons with an additional option for treatment of cartilage defects. This study aimed to produce in vitro engineered cartilage tissue by culturing and differentiating umbilical cord derived mesenchymal stem cells on biodegradable Poly(ε-caprolactone) (PCL) scaffold.
 Methods: Human umbilical cord derived mesen
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25

Rim, Yeri Alice, Yoojun Nam, Narae Park, Hyerin Jung, Kijun Lee, Jennifer Lee, and Ji Hyeon Ju. "Chondrogenic Differentiation from Induced Pluripotent Stem Cells Using Non-Viral Minicircle Vectors." Cells 9, no. 3 (March 1, 2020): 582. http://dx.doi.org/10.3390/cells9030582.

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Human degenerative cartilage has low regenerative potential. Chondrocyte transplantation offers a promising strategy for cartilage treatment and regeneration. Currently, chondrogenesis using human pluripotent stem cells (hiPSCs) is accomplished using human recombinant growth factors. Here, we differentiate hiPSCs into chondrogenic pellets using minicircle vectors. Minicircles are a non-viral gene delivery system that can produce growth factors without integration into the host genome. We generated minicircle vectors containing bone morphogenetic protein 2 (BMP2) and transforming growth factor
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26

Jiang, L., A. Ma, L. Song, Y. Hu, H. Dun, P. Daloze, M. Zafarullah, and H. Chen. "THE COMBINATION OF AUTOLOGOUS MESENCHYMAL STEM CELLS, ACELLULAR DERMAL MATRIX AND GROWTH FACTORS FOR CARTILAGE REGENERATION IN EXPERIMENTAL CARTILAGE DEFECT MODEL IN NONHUMAN PRIMATES." Transplantation Journal 90 (July 2010): 466. http://dx.doi.org/10.1097/00007890-201007272-00862.

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27

Tu, Vy Thi-Kieu, Ha Thi-Ngan Le, Xuan Hoang-Viet To, Phuc Dang-Ngoc Nguyen, Phat Duc Huynh, Thuan Minh Le, and Ngoc Bich Vu. "Method for in vitro production of cartilage microtissues from scaffold-free spheroids composed of human adipose-derived stem cells." Biomedical Research and Therapy 7, no. 4 (April 26, 2020): 3697–708. http://dx.doi.org/10.15419/bmrat.v7i4.597.

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Introduction: Cartilage damage is one of the injuries that is difficult for the human body to self-repair due to the avascular and completely mature tissue with only few stem or progenitor cells present. Recently, some studies showed that engineered cartilage tissues could be used to treat or improve this injury. This study aimed to produce the cartilage microtissues from the differentiation of scaffold-free spheroids composed of human adipose-derived stem cells.
 Methods: Human adipose-derived stem cells (ADSCs) were isolated and expanded following the previously published study. They we
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28

Liu, Jun-wei, Yong-li Wu, Wei Wei, Yan-ling Zhang, Di Liu, Xiao-xiu Ma, Chun Li, and Yu-yuan Ma. "Effect of Warm Acupuncture Combined with Bone Marrow Mesenchymal Stem Cells Transplantation on Cartilage Tissue in Rabbit Knee Osteoarthritis." Evidence-Based Complementary and Alternative Medicine 2021 (August 11, 2021): 1–12. http://dx.doi.org/10.1155/2021/5523726.

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The current study was designed to investigate the effect and underlying mechanism of warm acupuncture combined with bone marrow mesenchymal stem cells (BMSC) transplantation on cartilage tissue injury in rabbit knee osteoarthritis (KOA). In the study, 50 rabbits were randomly divided into 5 groups: blank group, KOA group, warm acupuncture group, BMSCs group, and warm acupuncture combined with BMSCs group. After warm acupuncture combined with BMSCs, the Modified Lequesne MG knee joint assessment scale was used to evaluate the degree of knee joint behavior, the Taiping Peng method generally obse
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29

Phull, Abdul-Rehman, Seong-Hui Eo, Qamar Abbas, Madiha Ahmed, and Song Ja Kim. "Applications of Chondrocyte-Based Cartilage Engineering: An Overview." BioMed Research International 2016 (2016): 1–17. http://dx.doi.org/10.1155/2016/1879837.

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Chondrocytes are the exclusive cells residing in cartilage and maintain the functionality of cartilage tissue. Series of biocomponents such as different growth factors, cytokines, and transcriptional factors regulate the mesenchymal stem cells (MSCs) differentiation to chondrocytes. The number of chondrocytes and dedifferentiation are the key limitations in subsequent clinical application of the chondrocytes. Different culture methods are being developed to overcome such issues. Using tissue engineering and cell based approaches, chondrocytes offer prominent therapeutic option specifically in
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30

Thompson, Seth D., Rajeswari Pichika, Richard L. Lieber, G. R. Scott Budinger, and Mitra Lavasani. "Systemic Transplantation of Adult Multipotent Stem Cells Functionally Rejuvenates Aged Articular Cartilage." Aging and disease 12, no. 3 (2021): 726. http://dx.doi.org/10.14336/ad.2020.1118.

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31

Hyc, Anna, Jacek Malejczyk, Anna Osiecka, and Stanislaw Moskalewski. "Immunological Response against Allogeneic Chondrocytes Transplanted into Joint Surface Defects in Rats." Cell Transplantation 6, no. 2 (March 1997): 119–24. http://dx.doi.org/10.1177/096368979700600205.

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Rat chondrocytes isolated from the articular–epiphyseal cartilage complex were transplanted into defects prepared in articular cartilage and subchondral bone. Transplants were taken for examination after 3 and 8 wk. Cartilage formed by syngeneic chondrocytes did not evoke formation of infiltrations. Contrary to that, in the vicinity of cartilage produced by allogeneic chondrocytes numerous infiltrating cells were present and cartilage resorption could be observed. Cyclosporine-A (CsA) treatment of recipients of allogeneic chondrocytes only partially suppressed accumulation of infiltrating cell
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32

Epperlein, H., D. Meulemans, M. Bronner-Fraser, H. Steinbeisser, and M. A. Selleck. "Analysis of cranial neural crest migratory pathways in axolotl using cell markers and transplantation." Development 127, no. 12 (June 15, 2000): 2751–61. http://dx.doi.org/10.1242/dev.127.12.2751.

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We have examined the ability of normal and heterotopically transplanted neural crest cells to migrate along cranial neural crest pathways in the axolotl using focal DiI injections and in situ hybridization with the neural crest marker, AP-2. DiI labeling demonstrates that cranial neural crest cells migrate as distinct streams along prescribed pathways to populate the maxillary and mandibular processes of the first branchial arch, the hyoid arch and gill arches 1–4, following migratory pathways similar to those observed in other vertebrates. Another neural crest marker, the transcription factor
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Cegielski, Marek, Wojciech Dziewiszek, Maciej Zabel, Piotr Dzięgiel, Dariusz Iżycki, Maciej Zatoński, and Marek Bochnia. "Experimental application of xenogenous antlerogenic cells in replacement of auricular cartilage in rabbits." Xenotransplantation 15, no. 6 (November 2008): 374–83. http://dx.doi.org/10.1111/j.1399-3089.2008.00497.x.

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34

Xia, Peng, Xinwei Wang, Qi Wang, Xiaoju Wang, Qiang Lin, Kai Cheng, and Xueping Li. "Low-Intensity Pulsed Ultrasound Promotes Autophagy-Mediated Migration of Mesenchymal Stem Cells and Cartilage Repair." Cell Transplantation 30 (January 1, 2021): 096368972098614. http://dx.doi.org/10.1177/0963689720986142.

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Mesenchymal stem cell (MSC) migration is promoted by low-intensity pulsed ultrasound (LIPUS), but its mechanism is unclear. Since autophagy is known to regulate cell migration, our study aimed to investigate if LIPUS promotes the migration of MSCs via autophagy regulation. We also aimed to investigate the effects of intra-articular injection of MSCs following LIPUS stimulation on osteoarthritis (OA) cartilage. For the in vitro study, rat bone marrow-derived MSCs were treated with an autophagy inhibitor or agonist, and then they were stimulated by LIPUS. Migration of MSCs was detected by transw
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35

Moskalewski, Stanislaw, Anna Hyc, Tomasz Grzela, and Jacek Malejczyk. "Differences in Cartilage Formed Intramuscularly or in Joint Surface Defects by Syngeneic Rat Chondrocytes Isolated from the Articular-Epiphyseal Cartilage Complex." Cell Transplantation 2, no. 6 (November 1993): 467–73. http://dx.doi.org/10.1177/096368979300200605.

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Syngeneic rat chondrocytes isolated from the articular-epiphyseal cartilage complex were suspended in hyaluronic acid and transplanted intramuscularly or into joint surface defects. Transplants were fixed in ruthenium hexammonium trichloride and embedded in glycol methacrylate. In cartilage nodules produced intramuscularly, chondrocyte hypertrophy and matrix calcification were observed after 2 wk. Partial ossification occurred after 4 wk and the cartilage was almost completely replaced by an ossicle after 8 wk. Only small, dispersed groups of chondrocytes remained within the ossicle. In cartil
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36

Chen, Yu-Chun, Hwa-Chang Liu, Feng-Huei Lin, and Chih-Hung Chang. "DEVELOPMENT OF ENGINEERED CARTILAGE PRODUCT FROM BONE MARROW MESENCHYMAL STEM CELLS: AN EXAMPLE IN TAIWAN." Journal of Musculoskeletal Research 24, no. 01 (March 2021): 2130001. http://dx.doi.org/10.1142/s0218957721300015.

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Cartilage can redistribute human body’s daily loads and decrease the friction force in the diarthrodial joints. However, it may be injured due to trauma, sports injury, biomechanical imbalance, and genetic disease. Microfracture (MF), osteochondral autograft transplantation (OAT), and autologous chondrocyte implantation (ACI) are the most common treatment procedures in the hospital. Recently, the concept of tissue engineering involving the combination of cells, scaffolds, and bioactive signals has inspired researchers. Our team of researchers synthesized a tri-copolymer from biological polymer
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37

Choi, Woo Hee, Hwal Ran Kim, Su Jeong Lee, Nayoung Jeong, So Ra Park, Byung Hyune Choi, and Byoung-Hyun Min. "Fetal Cartilage-Derived Cells Have Stem Cell Properties and Are a Highly Potent Cell Source for Cartilage Regeneration." Cell Transplantation 25, no. 3 (March 2016): 449–61. http://dx.doi.org/10.3727/096368915x688641.

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38

Ryu, Dong Jin, Yoon Sang Jeon, Jun Sung Park, Gi Cheol Bae, Jeong-seok Kim, and Myung Ku Kim. "Comparison of Bone Marrow Aspirate Concentrate and Allogenic Human Umbilical Cord Blood Derived Mesenchymal Stem Cell Implantation on Chondral Defect of Knee: Assessment of Clinical and Magnetic Resonance Imaging Outcomes at 2-Year Follow-Up." Cell Transplantation 29 (January 1, 2020): 096368972094358. http://dx.doi.org/10.1177/0963689720943581.

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Biological repair of cartilage lesions remains a significant clinical challenge. A wide variety of methods involving mesenchymal stem cells (MSCs) have been introduced. Because of the limitation of the results, most of the treatment methods have not yet been approved by the Food and Drug Administration (FDA). However, bone marrow aspirate concentrate (BMAC) and human umbilical cord blood derived mesenchymal stem cells (hUCB-MSCs) implantation were approved by Korea FDA. The aim of this study was to evaluate clinical and magnetic resonance imaging (MRI) outcomes after two different types of MSC
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39

Miura, Yasushi, and Shawn W. O'Driscoll. "Culturing Periosteum in Vitro: The Influence of Different Sizes of Explants." Cell Transplantation 7, no. 5 (September 1998): 453–57. http://dx.doi.org/10.1177/096368979800700504.

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Periosteal transplantation is being used clinically to repair articular defects. Isolated cells and very small periosteal explants can be grown in tissue culture, but it will be necessary to test larger sizes for tissue engineering to be applied to clinical transplantation of periosteum. This study was conducted to assess the chondrogenic potential of different sizes of periosteal explants in agarose culture. Ninety-six rabbit tibial periosteal explants in three different sizes (small 1.5 × 2, medium 3 × 2, and large 4 × 6 mm, 32 pieces per size) were cultured in agarose suspension for 6 wk an
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40

Basok, Y. B., A. M. Grigoryev, L. A. Kirsanova, A. D. Kirillova, A. M. Subbot, A. V. Tsvetkova, E. A. Nemets, and V. I. Sevastianov. "Comparative study of chondrogenesis of human adipose-derived mesenchymal stem cells when cultured in collagen-containing media under in vitro conditions." Russian Journal of Transplantology and Artificial Organs 23, no. 3 (September 16, 2021): 90–100. http://dx.doi.org/10.15825/1995-1191-2021-3-90-100.

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In terms of method of production, collagen carriers are subdivided into materials obtained on the basis of extracellular matrix (ECM) components, particularly collagen-containing hydrogels and decellularized tissue.Objective: to compare in vitro the ability of biopolymer microheterogeneous collagen-containing hydrogel (BMCH) and tissue-specific matrix from decellularized porcine articular cartilage (DPAC) to support adhesion, proliferation and chondrogenic differentiation of human adipose-derived mesenchymal stem cells (hAMSCs).Materials and methods. For cartilage decellularization, we carried
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41

Itokazu, Maki, Shigeyuki Wakitani, Hisashi Mera, Yoshihiro Tamamura, Yasushi Sato, Mutsumi Takagi, and Hiroaki Nakamura. "Transplantation of Scaffold-Free Cartilage-Like Cell-Sheets Made from Human Bone Marrow Mesenchymal Stem Cells for Cartilage Repair." CARTILAGE 7, no. 4 (June 23, 2016): 361–72. http://dx.doi.org/10.1177/1947603515627342.

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42

Jiang, Shuangpeng, Guangzhao Tian, Xu Li, Zhen Yang, Fuxin Wang, Zhuang Tian, Bo Huang, et al. "Research Progress on Stem Cell Therapies for Articular Cartilage Regeneration." Stem Cells International 2021 (February 12, 2021): 1–25. http://dx.doi.org/10.1155/2021/8882505.

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Injury of articular cartilage can cause osteoarthritis and seriously affect the physical and mental health of patients. Unfortunately, current surgical treatment techniques that are commonly used in the clinic cannot regenerate articular cartilage. Regenerative medicine involving stem cells has entered a new stage and is considered the most promising way to regenerate articular cartilage. In terms of theories on the mechanism, it was thought that stem cell-mediated articular cartilage regeneration was achieved through the directional differentiation of stem cells into chondrocytes. However, re
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43

Zhang, Rui, Qiaoxia Zhang, Zhiyu Zou, Zheng Li, Meng Jin, Jing An, Hui Li, and Jianbing Ma. "Curcumin Supplementation Enhances Bone Marrow Mesenchymal Stem Cells to Promote the Anabolism of Articular Chondrocytes and Cartilage Repair." Cell Transplantation 30 (January 1, 2021): 096368972199377. http://dx.doi.org/10.1177/0963689721993776.

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Mesenchymal stem cells derived from bone marrows (BMSCs) and curcumin derived from turmeric were used for osteoarthritis (OA) treatment, respectively. We invested the effects of curcumin supplementation for BMSC therapeutic effects. In vitro, rat BMSCs were identified by dual-immunofluorescent staining of CD44 and CD90, and flow cytometry. Primary articular chondrocytes were identified by toluidine blue staining and immunofluorescent staining of Col2a1. EdU incorporation, migration assay, real-time quantitative polymerase chain reaction, and Western blot analyses were performed to evaluate the
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44

Wu, Jiang, Guang Hui Wang, Hong Zhang, Yu Ping Wu, Yang Cheng Lv, Jing Song Liu, Jie Ke Ma, and Jiang Zhu. "Chondrogenic Ability of Bone Marrow Mesenchymal Stem Cells in Alginate and Collagen Sponge." Key Engineering Materials 474-476 (April 2011): 1935–38. http://dx.doi.org/10.4028/www.scientific.net/kem.474-476.1935.

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In the present study, we have demonstrated that alginate and collagen sponge can act as scaffolds in order to support 3-dimensional structure for the differentiated bone marrow derived mesenchymal stem cells (BMSCs) during chondrogenesis in vitro and in vivo. The chondrogenic induced BMSCs were well distributed and differentiation in scaffolds system before implantation, then they produced sufficient ECM in the implants to form chondroid aggregates in vivo. In our opinion, well-differentiated BMSCs is a crucial feature of cartilage repair and only can be achieved in scaffold matrix. Furthermor
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45

Kagimoto, Shintaro, Takanori Takebe, Shinji Kobayashi, Yuichiro Yabuki, Ayaka Hori, Koichi Hirotomi, Taro Mikami, Toshimasa Uemura, Jiro Maegawa, and Hideki Taniguchi. "Autotransplantation of Monkey Ear Perichondrium-Derived Progenitor Cells for Cartilage Reconstruction." Cell Transplantation 25, no. 5 (May 2016): 951–62. http://dx.doi.org/10.3727/096368916x690917.

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46

Lu, Tsai-Jung, Fang-Yao Chiu, Hsiao-Ying Chiu, Ming-Chau Chang, and Shih-Chieh Hung. "Chondrogenic Differentiation of Mesenchymal Stem Cells in Three-Dimensional Chitosan Film Culture." Cell Transplantation 26, no. 3 (March 2017): 417–27. http://dx.doi.org/10.3727/096368916x693464.

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Articular cartilage has a very limited capacity for self-repair, and mesenchymal stem cells (MSCs) have the potential to treat cartilage defects and osteoarthritis. However, in-depth mechanistic studies regarding their applications are required. Here we demonstrated the use of chitosan film culture for promoting chondrogenic differentiation of MSCs. We found that MSCs formed spheres 2 days after seeding on dishes coated with chitosan. When MSCs were induced in a chondrogenic induction medium on chitosan films, the size of the spheres continuously increased for up to 21 days. Alcian blue staini
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47

Liu, Jun-qi, Qi-wen Li, and Zhen Tan. "New Insights on Properties and Spatial Distributions of Skeletal Stem Cells." Stem Cells International 2019 (June 3, 2019): 1–11. http://dx.doi.org/10.1155/2019/9026729.

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Skeletal stem cells (SSCs) are postnatal self-renewing, multipotent, and skeletal lineage-committed progenitors that are capable of giving rise to cartilage, bone, and bone marrow stroma including marrow adipocytes and stromal cells in vitro and in an exogenous environment after transplantation in vivo. Identifying and isolating defined SSCs as well as illuminating their spatiotemporal properties contribute to our understating of skeletal biology and pathology. In this review, we revisit skeletal stem cells identified most recently and systematically discuss their origin and distributions.
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48

Aoyama, H., and K. Asamoto. "Determination of somite cells: independence of cell differentiation and morphogenesis." Development 104, no. 1 (September 1, 1988): 15–28. http://dx.doi.org/10.1242/dev.104.1.15.

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Somites are mesodermal structures which appear transiently in vertebrates in the course of their development. Cells situated ventromedially in a somite differentiate into the sclerotome, which gives rise to cartilage, while the other part of the somite differentiates into dermomyotome which gives rise to muscle and dermis. The sclerotome is further divided into a rostral half, where neural crest cells settle and motor nerves grow, and a caudal half. To find out when these axes are determined and how they rule later development, especially the morphogenesis of cartilage derived from the somites
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49

Gál, P., A. Nečas, L. Plánka, H. Kecová, L. Křen, P. Krupa, J. Hlučilová, and D. Usvald. "Chondrocytic Potential of Allogenic Mesenchymal Stem Cells Transplanted without Immunosuppression to Regenerate Physeal Defect in Rabbits." Acta Veterinaria Brno 76, no. 2 (2007): 265–75. http://dx.doi.org/10.2754/avb200776020265.

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Mesenchymal stem cells (MSCs) from bone marrow are multipotent cells capable of forming cartilage, bone, and other connective tissues. The objective of this study was to determine whether the use of allogenic mesenchymal stem cells could functionally heal a defect in the distal femoral physis in rabbits without the use of immunosuppressive therapy. A iatrogenic defect was created in the lateral femoral condyle of thirty-two New Zealand white rabbits, 7 weeks old, weighing 2.25 ± 0.24 kg. Each defect, 3.5 mm in width and 12 mm in length, in the right distal femoral physis was treated with allog
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50

Salamone, Monica, Salvatrice Rigogliuso, Aldo Nicosia, Marcello Tagliavia, Simona Campora, Paolo Cinà, Carmelo Bruno, and Giulio Ghersi. "Neural Crest-Derived Chondrocytes Isolation for Tissue Engineering in Regenerative Medicine." Cells 9, no. 4 (April 14, 2020): 962. http://dx.doi.org/10.3390/cells9040962.

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Chondrocyte transplantation has been successfully tested and proposed as a clinical procedure aiming to repair articular cartilage defects. However, the isolation of chondrocytes and the optimization of the enzymatic digestion process, as well as their successful in vitro expansion, remain the main challenges in cartilage tissue engineering. In order to address these issues, we investigated the performance of recombinant collagenases in tissue dissociation assays with the aim of isolating chondrocytes from bovine nasal cartilage in order to establish the optimal enzyme blend to ensure the best
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