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1

Cook, James L. "Three-dimensional chondrocyte culture : in vitro and in vivo applications /." free to MU campus, to others for purchase, 1998. http://wwwlib.umi.com/cr/mo/fullcit?p9924877.

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2

Srinivasan, Jayendran. "Investigation of internal fluid pressure in cells." Morgantown, W. Va. : [West Virginia University Libraries], 2005. https://eidr.wvu.edu/etd/documentdata.eTD?documentid=4177.

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Thesis (M.S.)--West Virginia University, 2005.<br>Title from document title page. Document formatted into pages; contains x, 114 p. : ill. (some col.). Includes abstract. Includes bibliographical references (p. 69-77).
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3

Mouw, Janna Kay. "Mechanoregulation of chondrocytes and chondroprogenitors the role of TGF-BETA and SMAD signaling /." Diss., Available online, Georgia Institute of Technology, 2005, 2005. http://etd.gatech.edu/theses/available/etd-11232005-103041/.

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Thesis (Ph. D.)--Bioengineering, Georgia Institute of Technology, 2006.<br>Harish Radhakrishna, Committee Member ; Christopher Jacobs, Committee Member ; Andres Garcia, Committee Member ; Marc E. Levenston, Committee Chair ; Barbara Boyan, Committee Member.
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4

Yang, Ziquan. "Repair of cartilage injury using gene modified stem cells and acellular cartilage matrix." Thesis, Queen's University Belfast, 2008. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.501585.

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5

Bishop, Joanna Charlotte. "Biology of the articular cartilage progenitor cells." Thesis, Cardiff University, 2004. http://orca.cf.ac.uk/55374/.

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6

Brodkin, Kathryn Rhea. "Chondrocyte behavior in monolayer culture : the effects of protein substrates and culture media." Thesis, Georgia Institute of Technology, 2002. http://hdl.handle.net/1853/20216.

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7

Tsang, Kwok-yeung. "Molecular pathogenesis of abnormal chondrocyte differentiation in a transgenic mouse model /." View the Table of Contents & Abstract, 2006. http://sunzi.lib.hku.hk/hkuto/record/B35132796.

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8

Togo, Takeshi. "Identification of cartilage progenitor cells in the adult ear perichondrium : utilization for cartilage reconstruction." Kyoto University, 2008. http://hdl.handle.net/2433/135826.

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9

Kraft, Jeffrey J. "Developing a cartilage tissue equivalent using chondrocytes and mesenchymal stem cells." Access to citation, abstract and download form provided by ProQuest Information and Learning Company; downloadable PDF file, 90 p, 2007. http://proquest.umi.com/pqdweb?did=1397900431&sid=6&Fmt=2&clientId=8331&RQT=309&VName=PQD.

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10

Clements, Kristen Mary. "Mechanical disruption of articular cartilage cells and matrix." Thesis, University of Bristol, 2000. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.340082.

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11

Marcus, Paula Louise. "Plasticity and interactions of articular cartilage progenitor cells." Thesis, Cardiff University, 2008. http://orca.cf.ac.uk/54742/.

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Articular cartilage is an avascular and aneural tissue and this is, in part, attributable to its low intrinsic capacity for repair after injury. Research is now focusing on alternate cell sources for tissue engineering of damaged cartilage, and recently a population of progenitor cells has been identified within the surface zone of bovine articular cartilage. These cells are capable of differentiating along a variety of mesenchymal lineages and are thought to be required for the appositional growth of the cartilage. The aims of this thesis were to further characterise these cells and determine
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12

Zhang, Shang. "Mesenchymal stem cells, cartilage regeneration and immune privilege." Thesis, University of Bristol, 2014. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.633157.

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Many studies have shown that mesenchymal stem cells (MSCs) can be used as immunosuppressants to treat graft-versus-host disease (GVHO) and autoimmune diseases. The injection of MSCs prolonged allogeneic solid organ transplantation in animal models. The current project aimed to investigate whether tissue-engineered cartilage derived from MSCs could be transplanted allogeneically. We mainly looked at murine MSCs (mMSCs) in this project. mMSCs are more difficult to isolate than human MSCs. We tried several methods to isolate mMSCs and found that a FACS isolated subpopulation of mMSCs, i.e. PaS ce
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13

Ayyalasomayajula, Madhavi V. S. "Influence of rearrangement of actin cytoskeleton on the overall material properties of ATDC5 cells during chondrogenesis." Morgantown, W. Va. : [West Virginia University Libraries], 2004. https://etd.wvu.edu/etd/controller.jsp?moduleName=documentdata&jsp%5FetdId=3580.

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Thesis (M.S.)--West Virginia University, 2004.<br>Title from document title page. Document formatted into pages; contains xi, 97 p. : ill. (some col.). Includes abstract. Includes bibliographical references (p. 68-70).
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14

Yoshimatsu, Masayoshi. "In vivo regeneration of rat laryngeal cartilage with mesenchymal stem cells derived from human induced pluripotent stem cells via neural crest cells." Doctoral thesis, Kyoto University, 2021. http://hdl.handle.net/2433/265189.

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京都大学<br>新制・課程博士<br>博士(医学)<br>甲第23417号<br>医博第4762号<br>新制||医||1052(附属図書館)<br>京都大学大学院医学研究科医学専攻<br>(主査)教授 松田 秀一特定拠点, 教授 妻木 範行, 教授 安達 泰治<br>学位規則第4条第1項該当<br>Doctor of Medical Science<br>Kyoto University<br>DFAM
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15

Fellows, Christopher R. "Analyses of articular cartilage-derived stem cells : identification of cellular markers for stem cells within the healthy and osteoarthritic knee articular cartilage." Thesis, Cardiff University, 2014. http://orca.cf.ac.uk/70446/.

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Previous studies have identified stem cell populations in articular cartilage using colony forming assays and mesenchymal stem cell (MSC) marker expression. The specificity of classical MSC markers for isolation of stem cells within articular cartilage is insufficient, with large and highly variable quantities being reported in the literature. This study has demonstrated, for the first time, a panel of stem cell markers specific for articular cartilage-derived stem cells (ACSC). ACSCs were isolated, quantified and cultured from healthy and OA joints. Stem cells were clonally-derived cell lines
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16

Stoker, Aaron. "Evaluation of the metabolic responses of normal and osteoarthritic cartilage in vitro and in vivo /." Free to MU Campus, others may purchase, 2004. http://wwwlib.umi.com/cr/mo/fullcit?p3144460.

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17

Yu, Yin. "Identification and characterization of cartilage progenitor cells by single cell sorting and cloning." Thesis, University of Iowa, 2012. https://ir.uiowa.edu/etd/3414.

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Cartilage lesion is a fairly common problem in orthopaedic practise. It is often a consequence of traumas, inflammatory conditions, and biomechanics alterations. However, as an avascular and aneural tissue, articular cartilage has minimal healing ability. Over the past decades, surgeons and scientists have proposed a nubmer of treatment strategies to promote restoration of articular cartilage, like arthroscopic lavage, microfracture surgery, osteochoncral autografts and allografts, autologous chondrocyte implantation, and other cell-based repairs. Nevertheless, these solutions often result in
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18

Tan, Zhijia, and 谭志佳. "Molecular analyses of chondrocyte differentiation and adaptation to ER stress." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2013. http://hdl.handle.net/10722/209435.

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Endochondral bone development depends on the progression of chondrocyte proliferation, hypertrophy and terminal differentiation, which requires precise transcriptional regulation and signaling coordination. Disturbance of this process would disrupt chondrocyte differentiation and lead to chondrodysplasias. In cells, a highly conserved mechanism, ER stress signaling, has been developed to sense the protein load and maintain the cellular homeostasis. In humans, mutations in COL10A1 induce ER stress and result in metaphyseal chondrodysplasia type Schmid (MCDS). Previous analysis of a MCDS mouse m
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19

Yu, Yin. "Articular cartilage tissue engineering using chondrogenic progenitor cell homing and 3D bioprinting." Diss., University of Iowa, 2015. https://ir.uiowa.edu/etd/6895.

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Articular cartilage damage associated with joint trauma seldom heals and often leads to osteoarthritis (OA). Current treatment often fails to regenerated functional cartilage close to native tissue. We previously identified a migratory chondrogenic progenitor cell (CPC) population that responded chemotactically to cell death and rapidly repopulated the injured cartilage matrix, which suggested their potential for cartilage repair. To test that potential we filled experimental full thickness chondral defects with an acellular hydrogel containing SDF-1α. We expect that SDF-1α can increase the re
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20

Lu, Luhui, and 陆璐慧. "Molecular control of osteo-chondroprogenitors formation." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2009. http://hub.hku.hk/bib/B44673966.

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21

Esa, Adam. "Characterising the role of articular cartilage progenitor cells in osteoarthritis." Thesis, Cardiff University, 2015. http://orca.cf.ac.uk/90195/.

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Osteoarthritis (OA) is a chronic and highly prevalent degenerative disease of the synovial joint leading to cartilage destruction and bone remodelling. The current management of end-stage OA is joint replacement, however, this procedure is not suitable for a subset of patients hence there is a growing need for alternative treatments and technologies to address this limitation. One such approach to this problem is the application of cell-based therapies that regenerate areas of damaged cartilage. Recently discovered articular cartilage progenitor cells (CPC) have been hallmarked as a potential
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22

Nelson, Larissa. "Evaluation of the potential for repair of degenerate hyaline cartilage in the osteoarthritic knee by cartilage stem cells." Thesis, Cardiff University, 2012. http://orca.cf.ac.uk/42362/.

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Osteoarthritis (OA) is a highly prevalent, debilitating disease affecting many joints including the knee. Despite the involvement of several tissues, it is believed that the articular cartilage is the primary site of pathogenesis in humans. Within this study, a new scoring system of OA was devised, incorporating the articular cartilage and underlying bone, aimed at providing a more comprehensive means of grading the severity of tissue damage. We examined changes progressively from mild to severe and were able to deduce from the scoring system that bone changes may precede those of the overlyin
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23

Tsang, Kwok-yeung, and 曾國揚. "Molecular pathogenesis of abnormal chondrocyte differentiation in a transgenic mouse model." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2006. http://hub.hku.hk/bib/B4501551X.

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24

Ahmed, Yasser Abdel Galil. "Analysis of physiological death in equine chondrocytes /." Connect to thesis, 2007. http://eprints.unimelb.edu.au/archive/00003656.

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25

Yang, Liu, and 楊柳. "Genetic analyses of terminal differentiation of hypertrophic chondrocytes." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2009. http://hdl.handle.net/10722/210320.

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26

Yang, Liu. "Genetic analyses of terminal differentiation of hypertrophic chondrocytes." Click to view the E-thesis via HKUTO, 2009. http://sunzi.lib.hku.hk/hkuto/record/B43223758.

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27

衛永剛 and Wing-kong Wai. "Abnormal chondrocyte differentiation: a transgenic model." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 1998. http://hub.hku.hk/bib/B31237800.

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28

Wai, Wing-kong. "Abnormal chondrocyte differentiation : a transgenic model /." Hong Kong : University of Hong Kong, 1998. http://sunzi.lib.hku.hk/hkuto/record.jsp?B19656439.

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29

Music, Ena. "Optimisation of methods for driving Chondrogenesis of human and ovine bone marrow–derived stromal cells." Thesis, Queensland University of Technology, 2021. https://eprints.qut.edu.au/207820/1/Ena_Music_Thesis.pdf.

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This thesis investigated the effects of different molecules and oxygen levels on the quality of engineered cartilage tissues produced using both human and sheep bone marrow–derived stromal cells. As damaged cartilage cannot repair naturally, it is hoped that cell-based repair strategies can delay the need for joint replacement surgery due to osteoarthritis, which affects 1 in 10 Australians.
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30

Denison, Tracy Adam. "The effect of fluid shear stress on growth plate." Diss., Atlanta, Ga. : Georgia Institute of Technology, 2009. http://hdl.handle.net/1853/29603.

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Thesis (Ph.D)--Biomedical Engineering, Georgia Institute of Technology, 2009.<br>Committee Chair: Boyan, Barbara; Committee Co-Chair: Schwartz, Zvi; Committee Member: Bonewald, Lynda; Committee Member: Jo, Hanjoong; Committee Member: Sambanis, Athanassios. Part of the SMARTech Electronic Thesis and Dissertation Collection.
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31

Heymer, Andrea. "Chondrogenic differentiation of human mesenchymal stem cells and articular cartilage reconstruction." kostenfrei, 2008. http://www.opus-bayern.de/uni-wuerzburg/volltexte/2008/2944/.

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32

Lee, Christopher S. D. "Directing the paracrine actions of adipose stem cells for cartilage regeneration." Diss., Georgia Institute of Technology, 2012. http://hdl.handle.net/1853/44713.

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Current cartilage repair methods are ineffective in restoring the mechanical and biological functions of native hyaline cartilage. Therefore, using the paracrine actions of stem cell therapies to stimulate endogenous cartilage regeneration has gained momentum. Adipose stem cells (ASCs) are an attractive option for this endeavor because of their accessibility, chondrogenic potential, and secretion of factors that promote connective tissue repair. In order to use the factors secreted by ASCs to stimulate cartilage regeneration, the signaling pathways that affect postnatal cartilage developmen
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33

Boyer, Sam. "Characterisation of articular cartilage progenitor cells : potential use in tissue engineering." Thesis, Cardiff University, 2006. http://orca.cf.ac.uk/56057/.

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Articular cartilage is a resilient and load bearing material that provides diarthrodial joints with excellent friction, lubrication and wear characteristics required for continuous motion. However, articular cartilage has a poor regenerative capacity and its degeneration is a common cause of morbidity in terms of loss of joint function and osteoarthritis, frequently resulting in the need for total knee replacement. Articular cartilage has a distinct zonal architecture with biochemical and cellular variations existing from the surface zone to the deeper calcified layers. Thus, the development o
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34

Ferng, Alice Shirong. "ENGINEERING ARTICULAR CARTILAGE FROM HUMAN AND CANINE NON-EMBRYONIC STEM CELLS." Thesis, The University of Arizona, 2009. http://hdl.handle.net/10150/192338.

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35

Al-Obaidi, Aida Hameed Hassan. "Preclinical studies for cartilage tissue engineering using induced pluripotent stem cells." Thesis, University of Bristol, 2017. https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.738237.

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36

Streppa, Heather Kirsten. "A novel co-culture model for the study of osteoarthritis in dogs /." free to MU campus, to others for purchase, 2004. http://wwwlib.umi.com/cr/mo/fullcit?p1422968.

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37

Lin, Zhen. "Chondrocyte : a target for the treatment of osteoarthritis." University of Western Australia. Orthopaedics Unit, 2007. http://theses.library.uwa.edu.au/adt-WU2007.0203.

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[Truncated abstract] Osteoarthritis (OA) is the most common form of arthritis, characterized by progressively degeneration of articular cartilage. Chondrocyte is the only cell type in articular cartilage tissue and responsible for cartilage matrix turnover. This thesis focuses on the biological and genetic behaviors of human chondrocyte and potential therapeutic strategies that target on chondrocyte. Chondrocytes have been used for the tissue-engineered cartilage construction, especially in articular cartilage repair. The technique of chondrocyte-base tissue engineering utilizes in vitro propa
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38

Fabre, Hugo. "Cartilage Tissue Engineering Using Mesenchymal Stem Cells : development of a screening method by flow cytometry to characterize diverse sources of human mesenchymal stem cells and to evaluate the quality of their chondrogenic conversion." Thesis, Lyon 1, 2015. http://www.theses.fr/2015LYO10186.

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Articular cartilage is made up of dense, connective tissue localized at the junction of several locations in the skeleton. It covers the surface of the joints to ensure that bones can move. It is an avascular tissue that is not innervated and is composed primarily of a single cell type, the chondrocyte, which synthesizes an abundant extracellular matrix (ECM). Osteoarthritis (OA), a degenerative disease of articular cartilage, is characterized by the degradation of the ECM, associated with increased secretion of matrix metalloproteinases (MMPs) and aggrecanases. In addition, the OA process ind
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39

Nettles, Dana Lynn. "Evaluation of chitosan as a cell scaffolding material for cartilage tissue engineering." Master's thesis, Mississippi State : Mississippi State University, 2001. http://library.msstate.edu/etd/show.asp?etd=etd-10262001-114635.

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40

Nasu, Akira. "Genetically Matched Human iPS Cells Reveal that Propensity for Cartilage and Bone Differentiation Differs with Clones, not Cell Type of Origin." Kyoto University, 2014. http://hdl.handle.net/2433/189661.

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41

Viswanathan, Sundar. "Finite element analysis of interaction between actin cytoskeleton and intracellular fluid in prechondrocytes and chondrocytes subjected to compressive loading." Morgantown, W. Va. : [West Virginia University Libraries], 2004. https://etd.wvu.edu/etd/controller.jsp?moduleName=documentdata&jsp%5FetdId=3664.

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Thesis (M.S.)--West Virginia University, 2004.<br>Title from document title page. Document formatted into pages; contains ix, 138 p. : ill. (some col.). Includes abstract. Includes bibliographical references (p. 93-94).
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42

Leung, Y. L., and 梁宇亮. "Transcriptional regulators of col10al in chondrocyte differentiation." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2003. http://hub.hku.hk/bib/B31244440.

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43

Chen, Xike. "Integration Capacity of Human Induced Pluripotent Stem Cell-Derived Cartilage." Kyoto University, 2019. http://hdl.handle.net/2433/242390.

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44

Yagi, Rieko. "Bcl-2 Regulates Chondrocyte Phenotype Through MEK-ERK1/2 Pathway; Relevance to Osteoarthritis and Cartilage Biology." [Kent, Ohio] : Kent State University, 2005. http://rave.ohiolink.edu/etdc/view?acc%5Fnum=kent1118329494.

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Thesis (Ph.D.)--Kent State University, 2005.<br>Title from PDF t.p. (viewed Sept. 5, 2006). Advisor: Walter E. Horton. Keywords: chondrocytes; osteoarthritis; Sox9; Bcl-2; MEK-ERK 1/2. Includes bibliographical references (p. 91-106).
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45

Vail, Daniel Joseph. "Mapping the Way Toward an Engineered Articular Cartilage:A Complete Transcriptional Characterization of Native and MSC-Derived Cartilage." Case Western Reserve University School of Graduate Studies / OhioLINK, 2021. http://rave.ohiolink.edu/etdc/view?acc_num=case162644731682198.

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46

Ahmed, Saima. "Repairing injured articular cartilage : investigation of potential mechanisms using mesenchymal stem cells." Thesis, University of Sheffield, 2017. http://etheses.whiterose.ac.uk/17872/.

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47

Leung, Ching-man, and 梁靜雯. "Effects of Ext1 and Ext2 mutations in a chondrocyte cell line on heparan sulfate synthesis and in vitro chondrogenesis." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2002. http://hub.hku.hk/bib/B31227569.

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48

Loke, Chee Wui. "Finite element modeling of cells in response to loading effect of cytoskeleton /." Morgantown, W. Va. : [West Virginia University Libraries], 2005. https://etd.wvu.edu/etd/controller.jsp?moduleName=documentdata&jsp%5FetdId=4036.

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Thesis (M.S.)--West Virginia University, 2005.<br>Title from document title page. Document formatted into pages; contains xi, 86 p. : ill. (some col.). Includes abstract. Includes bibliographical references (p. 59-62).
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49

Mazor, Marija. "Changes in chondrogenic progenitor populations associated with osteoarthritis grades." Thesis, Orléans, 2016. http://www.theses.fr/2016ORLE2084.

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L'arthrose (OA) est une maladie dégénérative avec un impact remarquable sur la qualité de vie. Pourtant, aucune intervention pharmacologique entièrement appropriée, aucune thérapie biologique ou procédure n'entraînent la dégradation progressive de l'articulation OA. Ici, nous explorons les cellules souches mésenchymateuses (MSC) - précurseurs multi-potentiels de cellules qui peuvent être isolées à partir de différents niveaux de dégradation du cartilage. Nous émettons l'hypothèse que les cellules progénitrices mésenchymateuses (CPM) pourraient servir comme une thérapie potentielle. Le cartilag
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50

Huang, Zhao [Verfasser]. "In vitro differentiation of chondrogenic cells in three-dimensional scaffold-assisted culture for cartilage repair and characterization of cartilage sources / Zhao Huang." Berlin : Medizinische Fakultät Charité - Universitätsmedizin Berlin, 2017. http://d-nb.info/1127045490/34.

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