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Artículos de revistas sobre el tema "Cartilage cells"

Autor: Grafiati

Publicado: 4 de junio de 2021

Última modificación: 5 de marzo de 2023

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1

Åberg, Thomas, Ritva Rice, David Rice, Irma Thesleff, and Janna Waltimo-Sirén. "Chondrogenic Potential of Mouse Calvarial Mesenchyme." Journal of Histochemistry & Cytochemistry 53, no. 5 (May 2005): 653–63. http://dx.doi.org/10.1369/jhc.4a6518.2005.

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Facial and calvarial bones form intramembranously without a cartilagenous model; however, cultured chick calvarial mesenchyme cells may differentiate into both osteoblasts and chondroblasts and, in rodents, small cartilages occasionally form at the sutures in vivo. Therefore, we wanted to investigate what factors regulate normal differentiation of calvarial mesenchymal cells directly into osteoblasts. In embryonic mouse heads and in cultured tissue explants, we analyzed the expression of selected transcription factors and extracellular matrix molecules associated with bone and cartilage develo

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2

Holmbeck, Kenn, Paolo Bianco, Kali Chrysovergis, Susan Yamada, and Henning Birkedal-Hansen. "MT1-MMP–dependent, apoptotic remodeling of unmineralized cartilage." Journal of Cell Biology 163, no. 3 (November 10, 2003): 661–71. http://dx.doi.org/10.1083/jcb.200307061.

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Skeletal tissues develop either by intramembranous ossification, where bone is formed within a soft connective tissue, or by endochondral ossification. The latter proceeds via cartilage anlagen, which through hypertrophy, mineralization, and partial resorption ultimately provides scaffolding for bone formation. Here, we describe a novel and essential mechanism governing remodeling of unmineralized cartilage anlagen into membranous bone, as well as tendons and ligaments. Membrane-type 1 matrix metalloproteinase (MT1-MMP)–dependent dissolution of unmineralized cartilages, coupled with apoptosis

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3

Yi, Hee-Gyeong, Yeong-Jin Choi, Jin Woo Jung, Jinah Jang, Tae-Ha Song, Suhun Chae, Minjun Ahn, Tae Hyun Choi, Jong-Won Rhie, and Dong-Woo Cho. "Three-dimensional printing of a patient-specific engineered nasal cartilage for augmentative rhinoplasty." Journal of Tissue Engineering 10 (January 2019): 204173141882479. http://dx.doi.org/10.1177/2041731418824797.

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Autologous cartilages or synthetic nasal implants have been utilized in augmentative rhinoplasty to reconstruct the nasal shape for therapeutic and cosmetic purposes. Autologous cartilage is considered to be an ideal graft, but has drawbacks, such as limited cartilage source, requirements of additional surgery for obtaining autologous cartilage, and donor site morbidity. In contrast, synthetic nasal implants are abundantly available but have low biocompatibility than the autologous cartilages. Moreover, the currently used nasal cartilage grafts involve additional reshaping processes, by meticu

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4

Mazor, Marija, Annabelle Cesaro, Mazen Ali, Thomas M. Best, Eric Lespessailles, and Hechmi Toumi. "Progenitor Cells From Cartilage." Medicine & Science in Sports & Exercise 49, no. 5S (May 2017): 681. http://dx.doi.org/10.1249/01.mss.0000518798.14205.0d.

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5

Benjamin, M., C. W. Archer, and J. R. Ralphs. "Cytoskeleton of cartilage cells." Microscopy Research and Technique 28, no. 5 (August 1, 1994): 372–77. http://dx.doi.org/10.1002/jemt.1070280503.

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6

Suchorska, Wiktoria Maria, Ewelina Augustyniak, Magdalena Richter, Magdalena Łukjanow, Violetta Filas, Jacek Kaczmarczyk, and Tomasz Trzeciak. "Modified methods for efficiently differentiating human embryonic stem cells into chondrocyte-like cells." Postępy Higieny i Medycyny Doświadczalnej 71, no. 1 (June 19, 2017): 0. http://dx.doi.org/10.5604/01.3001.0010.3831.

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Human articular cartilage has a poor regenerative capacity. This often results in the serious joint disease- osteoarthritis (OA) that is characterized by cartilage degradation. An inability to self-repair provided extensive studies on AC regeneration. The cell-based cartilage tissue engineering is a promising approach for cartilage regeneration. So far, numerous cell types have been reported to show chondrogenic potential, among others human embryonic stem cells (hESCs).

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7

Le, Hanxiang, Weiguo Xu, Xiuli Zhuang, Fei Chang, Yinan Wang, and Jianxun Ding. "Mesenchymal stem cells for cartilage regeneration." Journal of Tissue Engineering 11 (January 2020): 204173142094383. http://dx.doi.org/10.1177/2041731420943839.

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Cartilage injuries are typically caused by trauma, chronic overload, and autoimmune diseases. Owing to the avascular structure and low metabolic activities of chondrocytes, cartilage generally does not self-repair following an injury. Currently, clinical interventions for cartilage injuries include chondrocyte implantation, microfracture, and osteochondral transplantation. However, rather than restoring cartilage integrity, these methods only postpone further cartilage deterioration. Stem cell therapies, especially mesenchymal stem cell (MSCs) therapies, were found to be a feasible strategy in

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8

Zhang, Hong, Xiaopeng Zhao, Zhiguang Zhang, Weiwei Chen, and Xinli Zhang. "An Immunohistochemistry Study of Sox9, Runx2, and Osterix Expression in the Mandibular Cartilages of Newborn Mouse." BioMed Research International 2013 (2013): 1–11. http://dx.doi.org/10.1155/2013/265380.

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The purpose of this study is to investigate the spacial expression pattern and functional significance of three key transcription factors related to bone and cartilage formation, namely, Sox9, Runx2, and Osterix in cartilages during the late development of mouse mandible. Immunohistochemical examinations of Sox9, Runx2, and Osterix were conducted in the mandibular cartilages of the 15 neonatal C57BL/6N mice. In secondary cartilages, both Sox9 and Runx2 were weakly expressed in the polymorphic cell zone, strongly expressed in the flattened cell zone and throughout the entire hypertrophic cell z

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9

Hayes, Anthony J., John Whitelock, and James Melrose. "Regulation of FGF-2, FGF-18 and Transcription Factor Activity by Perlecan in the Maturational Development of Transitional Rudiment and Growth Plate Cartilages and in the Maintenance of Permanent Cartilage Homeostasis." International Journal of Molecular Sciences 23, no. 4 (February 9, 2022): 1934. http://dx.doi.org/10.3390/ijms23041934.

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The aim of this study was to highlight the roles of perlecan in the regulation of the development of the rudiment developmental cartilages and growth plate cartilages, and also to show how perlecan maintains permanent articular cartilage homeostasis. Cartilage rudiments are transient developmental templates containing chondroprogenitor cells that undergo proliferation, matrix deposition, and hypertrophic differentiation. Growth plate cartilage also undergoes similar changes leading to endochondral bone formation, whereas permanent cartilage is maintained as an articular structure and does not

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10

Schilling, T. F., C. Walker, and C. B. Kimmel. "The chinless mutation and neural crest cell interactions in zebrafish jaw development." Development 122, no. 5 (May 1, 1996): 1417–26. http://dx.doi.org/10.1242/dev.122.5.1417.

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During vertebrate development, neural crest cells are thought to pattern many aspects of head organization, including the segmented skeleton and musculature of the jaw and gills. Here we describe mutations at the gene chinless, chn, that disrupt the skeletal fates of neural crest cells in the head of the zebrafish and their interactions with muscle precursors. chn mutants lack neural-crest-derived cartilage and mesoderm-derived muscles in all seven pharyngeal arches. Fate mapping and gene expression studies demonstrate the presence of both undifferentiated cartilage and muscle precursors in mu

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11

Mackie, E. J., I. Thesleff, and R. Chiquet-Ehrismann. "Tenascin is associated with chondrogenic and osteogenic differentiation in vivo and promotes chondrogenesis in vitro." Journal of Cell Biology 105, no. 6 (December 1, 1987): 2569–79. http://dx.doi.org/10.1083/jcb.105.6.2569.

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The tissue distribution of the extracellular matrix glycoprotein, tenascin, during cartilage and bone development in rodents has been investigated by immunohistochemistry. Tenascin was present in condensing mesenchyme of cartilage anlagen, but not in the surrounding mesenchyme. In fully differentiated cartilages, tenascin was only present in the perichondrium. In bones that form by endochondral ossification, tenascin reappeared around the osteogenic cells invading the cartilage model. Tenascin was also present in the condensing mesenchyme of developing bones that form by intramembranous ossifi

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12

Jian, Quan-Liang, Wei-Chun HuangFu, Yen-Hua Lee, and I.-Hsuan Liu. "Age, but not short-term intensive swimming, affects chondrocyte turnover in zebrafish vertebral cartilage." PeerJ 6 (October 1, 2018): e5739. http://dx.doi.org/10.7717/peerj.5739.

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Both age and intensive exercise are generally considered critical risk factors for osteoarthritis. In this work, we intend to establish zebrafish models to assess the role of these two factors on cartilage homeostasis. We designed a swimming device for zebrafish intensive exercise. The body measurements, bone mineral density (BMD) and the histology of spinal cartilages of 4- and 12-month-old zebrafish, as well the 12-month-old zebrafish before and after a 2-week exercise were compared. Our results indicate that both age and exercise affect the body length and body weight, and the micro-compute

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13

Kurenkova, Anastasiia D., Irina A. Romanova, Pavel D. Kibirskiy, Peter Timashev, and Ekaterina V. Medvedeva. "Strategies to Convert Cells into Hyaline Cartilage: Magic Spells for Adult Stem Cells." International Journal of Molecular Sciences 23, no. 19 (September 22, 2022): 11169. http://dx.doi.org/10.3390/ijms231911169.

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Damaged hyaline cartilage gradually decreases joint function and growing pain significantly reduces the quality of a patient’s life. The clinically approved procedure of autologous chondrocyte implantation (ACI) for treating knee cartilage lesions has several limits, including the absence of healthy articular cartilage tissues for cell isolation and difficulties related to the chondrocyte expansion in vitro. Today, various ACI modifications are being developed using autologous chondrocytes from alternative sources, such as the auricles, nose and ribs. Adult stem cells from different tissues ar

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14

Kirasirova, E. A., N. V. Lafutkina, R. A. Rezakov, R. F. Mamedov, and I. F. Al-Assaf. "PATHOMORPHOLOGICAL CHANGES IN THE CARTILAGE OF THE TRACHEA DEPENDING ON TERMS OF THE INTUBATION." Folia Otorhinolaryngologiae et Pathologiae Respiratoriae 25, no. 3 (2019): 87–93. http://dx.doi.org/10.33848/foliorl23103825-2019-25-3-87-93.

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Objective - to study the nature and prevalence of pathological changes in the cartilage of the trachea depending on the duration of intubation according to the results of pathomorphological studies. Materials and methods. Pathomorphological study of cartilage of the anterior tracheal wall was carried out on 37 patients at different times of mechanical ventilation. Depending on the timing of the ventilator before the tracheostomy, all patients were divided into three groups. In 10 people, the duration of ventilation until tracheostomy was no more than 3 days, in 15 people - 4 -7 days and in 12

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15

Wang, Mingjie, Zhiguo Yuan, Ning Ma, Chunxiang Hao, Weimin Guo, Gengyi Zou, Yu Zhang, et al. "Advances and Prospects in Stem Cells for Cartilage Regeneration." Stem Cells International 2017 (2017): 1–16. http://dx.doi.org/10.1155/2017/4130607.

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The histological features of cartilage call attention to the fact that cartilage has a little capacity to repair itself owing to the lack of a blood supply, nerves, or lymphangion. Stem cells have emerged as a promising option in the field of cartilage tissue engineering and regenerative medicine and could lead to cartilage repair. Much research has examined cartilage regeneration utilizing stem cells. However, both the potential and the limitations of this procedure remain controversial. This review presents a summary of emerging trends with regard to using stem cells in cartilage tissue engi

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16

Soliman, Soha A., Basma Mohamed Kamal, and Hanan H. Abd-Elhafeez. "Cellular Invasion and Matrix Degradation, a Different Type of Matrix-Degrading Cells in the Cartilage of Catfish (Clarias gariepinus) and Japanese Quail Embryos (Coturnix coturnix japonica)." Microscopy and Microanalysis 25, no. 05 (October 2019): 1283–92. http://dx.doi.org/10.1017/s1431927619014892.

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AbstractWe previously studied the phenomena of the mesenchymal cell-dependent mode of cartilage growth in quail and catfish. Thus, we selected the two cartilage models in which mesenchymal cells participate in their growth. In such models, cartilage degradation occurred to facilitate cellular invasion. The studies do not explain the nature of the cartilage degrading cells. The current study aims to explore the nature of the cartilage-degrading cells using transmission electron microscopy (TEM) and immunohistochemistry. Samples of cartilage have been isolated from the air-breathing organ of cat

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17

Peng, Haining, Yi Zhang, Zhongkai Ren, Ziran Wei, Renjie Chen, Yingze Zhang, Xiaohong Huang, and Tengbo Yu. "Cartilaginous Metabolomics Reveals the Biochemical-Niche Fate Control of Bone Marrow-Derived Stem Cells." Cells 11, no. 19 (September 21, 2022): 2951. http://dx.doi.org/10.3390/cells11192951.

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Joint disorders have become a global health issue with the growth of the aging population. Screening small active molecules targeting chondrogenic differentiation of bone marrow-derived stem cells (BMSCs) is of urgency. In this study, microfracture was employed to create a regenerative niche in rabbits (n = 9). Cartilage samples were collected four weeks post-surgery. Microfracture-caused morphological (n = 3) and metabolic (n = 6) changes were detected. Non-targeted metabolomic analysis revealed that there were 96 differentially expressed metabolites (DEMs) enriched in 70 pathways involved in

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18

Zhang, Jianying, Shiwu Dong, Wesley Sivak, Hui Bin Sun, and Kai Tao. "Stem Cells in Cartilage Regeneration." Stem Cells International 2017 (2017): 1–2. http://dx.doi.org/10.1155/2017/7034726.

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19

Kistler, Andreas, Brigitta Galli, and Herbert Kuhn. "Retinoic acid-induced cartilage degradation is caused by cartilage cells." Roux's Archives of Developmental Biology 199, no. 7 (July 1991): 377–86. http://dx.doi.org/10.1007/bf01705847.

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20

CHEN, JING, CHUNGEN GUO, HONGSHENG LI, XIAOQIN ZHU, SHUYUAN XIONG, and JIANXIN CHEN. "NONLINEAR SPECTRAL IMAGING OF ELASTIC CARTILAGE IN RABBIT EARS." Journal of Innovative Optical Health Sciences 06, no. 03 (July 2013): 1350024. http://dx.doi.org/10.1142/s1793545813500247.

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Elastic cartilage in the rabbit external ear is an important animal model with attractive potential value for researching the physiological and pathological states of cartilages especially during wound healing. In this work, nonlinear optical microscopy based on two-photon excited fluorescence and second harmonic generation were employed for imaging and quantifying the intact elastic cartilage. The morphology and distribution of main components in elastic cartilage including cartilage cells, collagen and elastic fibers were clearly observed from the high-resolution two-dimensional nonlinear op

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21

Longo, Umile Giuseppe, Stefano Petrillo, Edoardo Franceschetti, Alessandra Berton, Nicola Maffulli, and Vincenzo Denaro. "Stem Cells and Gene Therapy for Cartilage Repair." Stem Cells International 2012 (2012): 1–9. http://dx.doi.org/10.1155/2012/168385.

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Cartilage defects represent a common problem in orthopaedic practice. Predisposing factors include traumas, inflammatory conditions, and biomechanics alterations. Conservative management of cartilage defects often fails, and patients with this lesions may need surgical intervention. Several treatment strategies have been proposed, although only surgery has been proved to be predictably effective. Usually, in focal cartilage defects without a stable fibrocartilaginous repair tissue formed, surgeons try to promote a natural fibrocartilaginous response by using marrow stimulating techniques, such

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22

Ranger, Ann M., Louis C. Gerstenfeld, Jinxi Wang, Tamiyo Kon, Hyunsu Bae, Ellen M. Gravallese, Melvin J. Glimcher, and Laurie H. Glimcher. "The Nuclear Factor of Activated T Cells (Nfat) Transcription Factor Nfatp (Nfatc2) Is a Repressor of Chondrogenesis." Journal of Experimental Medicine 191, no. 1 (January 3, 2000): 9–22. http://dx.doi.org/10.1084/jem.191.1.9.

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Nuclear factor of activated T cells (NFAT) transcription factors regulate gene expression in lymphocytes and control cardiac valve formation. Here, we report that NFATp regulates chondrogenesis in the adult animal. In mice lacking NFATp, resident cells in the extraarticular connective tissues spontaneously differentiate to cartilage. These cartilage cells progressively differentiate and the tissue undergoes endochondral ossification, recapitulating the development of endochondral bone. Proliferation of already existing articular cartilage cells also occurs in some older animals. At both sites,

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23

Bae, Jung Yoon, Kazuaki Matsumura, Shigeyuki Wakitani, Amu Kawaguchi, Sadami Tsutsumi, and Suong-Hyu Hyon. "Beneficial Storage Effects of Epigallocatechin-3-O-Gallate on the Articular Cartilage of Rabbit Osteochondral Allografts." Cell Transplantation 18, no. 5-6 (May 2009): 505–12. http://dx.doi.org/10.1177/096368970901805-604.

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A fresh osteochondral allograft is one of the most effective treatments for cartilage defects of the knee. Despite the clinical success, fresh osteochondral allografts have great limitations in relation to the short storage time that cartilage tissues can be well-preserved. Fresh osteochondral grafts are generally stored in culture medium at 4°C. While the viability of articular cartilage stored in culture medium is significantly diminished within 1 week, appropriate serology testing to minimize the chances for the disease transmission requires a minimum of 2 weeks. (–)-Epigallocatechin-3- O-g

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24

A Soliman, Soha. "MMP-9 Expression in Normal Rabbit Chondrocytes." Cytology & Histology International Journal 5, no. 1 (2021): 1–9. http://dx.doi.org/10.23880/chij-16000131.

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Chondrocytes regulate anabolic and catabolic processes to maintain the extracellular matrix components. Catabolic activities depend on the proteolytic action of the matrix -degrading enzymes including ADAMTS (A disintegrin and metalloproteinases) and MMP (Matrix Metalloproteinase). The current study explored the distribution of MMP-9 in normal articular cartilages of the embryos rabbit. Articular cartilage has grown by appositional growth that the perichondrial stem cells differentiate into chondrocytes. MMP-9 positive perichondrial stem cells or chondroblasts and early chondrocytes. Mature ch

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25

Sun, GW, H. Kobayashi, M. Suzuki, N. Kanayama, and T. Terao. "Production of cartilage link protein by human granulosa-lutein cells." Journal of Endocrinology 175, no. 2 (November 1, 2002): 505–15. http://dx.doi.org/10.1677/joe.0.1750505.

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Link protein (LP), an extracellular matrix protein in cartilage, stabilizes aggregates of hyaluronic acid (HA) and proteoglycans, including aggrecan and inter-alpha-trypsin inhibitor (ITI). We have shown previously that cartilage LP is present in the maturing rat and mouse ovary. In the present study, we have employed immunohistochemistry to examine the anatomical distribution of cartilage LP in the human ovary. The expression of cartilage LP was selectively detected in the cells within the granulosa compartment of the preovulatory dominant follicle. The HA-positive granulosa-lutein cells were

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26

Sen, Rwik, Sofia Pezoa, Lomeli Carpio Shull, Laura Hernandez-Lagunas, Lee Niswander, and Kristin Artinger. "Kat2a and Kat2b Acetyltransferase Activity Regulates Craniofacial Cartilage and Bone Differentiation in Zebrafish and Mice." Journal of Developmental Biology 6, no. 4 (November 12, 2018): 27. http://dx.doi.org/10.3390/jdb6040027.

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Cranial neural crest cells undergo cellular growth, patterning, and differentiation within the branchial arches to form cartilage and bone, resulting in a precise pattern of skeletal elements forming the craniofacial skeleton. However, it is unclear how cranial neural crest cells are regulated to give rise to the different shapes and sizes of the bone and cartilage. Epigenetic regulators are good candidates to be involved in this regulation, since they can exert both broad as well as precise control on pattern formation. Here, we investigated the role of the histone acetyltransferases Kat2a an

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27

Schilling, T. F., and C. B. Kimmel. "Musculoskeletal patterning in the pharyngeal segments of the zebrafish embryo." Development 124, no. 15 (August 1, 1997): 2945–60. http://dx.doi.org/10.1242/dev.124.15.2945.

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The head skeleton and muscles of the zebrafish develop in a stereotyped pattern in the embryo, including seven pharyngeal arches and a basicranium underlying the brain and sense organs. To investigate how individual cartilages and muscles are specified and organized within each head segment, we have examined their early differentiation using Alcian labeling of cartilage and expression of several molecular markers of muscle cells. Zebrafish larvae begin feeding by four days after fertilization, but cartilage and muscle precursors develop in the pharyngeal arches up to 2 days earlier. These chon

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28

McBurney, Kim M., and Glenda M. Wright. "Chondrogenesis of a non-collagen-based cartilage in the sea lamprey, Petromyzon marinus." Canadian Journal of Zoology 74, no. 12 (December 1, 1996): 2118–30. http://dx.doi.org/10.1139/z96-241.

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Chondrogenesis of the trabeculae, non-collagen-based cartilages in prolarval stages of the sea lamprey, Petromyzon marinus, was examined by light and electron microscopy. Chondrogenesis of the trabecular cartilages in prolarval lampreys commenced with the formation of mesenchymal condensations. Two peaks in mesenchymal cell density occurred, one prior to condensation formation and a second immediately before cartilage differentiation. The possibility of inductive influences by epithelio-mesenchymal interactions on the initiation of chondrogenesis is discussed. Bilateral condensations first app

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29

Rim, Yeri Alice, Yoojun Nam, and Ji Hyeon Ju. "Application of Cord Blood and Cord Blood-Derived Induced Pluripotent Stem Cells for Cartilage Regeneration." Cell Transplantation 28, no. 5 (September 25, 2018): 529–37. http://dx.doi.org/10.1177/0963689718794864.

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Regeneration of articular cartilage is of great interest in cartilage tissue engineering since articular cartilage has a low regenerative capacity. Due to the difficulty in obtaining healthy cartilage for transplantation, there is a need to develop an alternative and effective regeneration therapy to treat degenerative or damaged joint diseases. Stem cells including various adult stem cells and pluripotent stem cells are now actively used in tissue engineering. Here, we provide an overview of the current status of cord blood cells and induced pluripotent stem cells derived from these cells in

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30

Kotaka, Shinji, Shigeyuki Wakitani, Akira Shimamoto, Naosuke Kamei, Mikiya Sawa, Nobuo Adachi, and Mituo Ochi. "Magnetic Targeted Delivery of Induced Pluripotent Stem Cells Promotes Articular Cartilage Repair." Stem Cells International 2017 (December 26, 2017): 1–7. http://dx.doi.org/10.1155/2017/9514719.

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Cartilage regeneration treatments using stem cells are associated with problems due to the cell source and the difficulty of delivering the cells to the cartilage defect. We consider labeled induced pluripotent stem (iPS) cells to be an ideal source of cells for tissue regeneration, and if iPS cells could be delivered only into cartilage defects, it would be possible to repair articular cartilage. Consequently, we investigated the effect of magnetically labeled iPS (m-iPS) cells delivered into an osteochondral defect by magnetic field on the repair of articular cartilage. iPS cells were labele

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Wang, L., M. Lazebnik, and M. S. Detamore. "Hyaline cartilage cells outperform mandibular condylar cartilage cells in a TMJ fibrocartilage tissue engineering application." Osteoarthritis and Cartilage 17, no. 3 (March 2009): 346–53. http://dx.doi.org/10.1016/j.joca.2008.07.004.

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32

Schmitt, Andreas, Martijn van Griensven, Andreas B. Imhoff, and Stefan Buchmann. "Application of Stem Cells in Orthopedics." Stem Cells International 2012 (2012): 1–11. http://dx.doi.org/10.1155/2012/394962.

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Stem cell research plays an important role in orthopedic regenerative medicine today. Current literature provides us with promising results from animal research in the fields of bone, tendon, and cartilage repair. While early clinical results are already published for bone and cartilage repair, the data about tendon repair is limited to animal studies. The success of these techniques remains inconsistent in all three mentioned areas. This may be due to different application techniques varying from simple mesenchymal stem cell injection up to complex tissue engineering. However, the ideal carri

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33

Zheng, Min. "Stem Cells Promote the Regeneration of Knee Joint Degenerative Bone and Articular Cartilage." Journal of Healthcare Engineering 2022 (March 24, 2022): 1–7. http://dx.doi.org/10.1155/2022/9533211.

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Cartilage damage has a certain ability to spontaneously repair, but the repaired tissue often shows the phenomenon of cartilage terminal differentiation, which causes irreversible damage to its structure and function and seriously affects the quality of life and work of patients. It is of great significance to study the problems encountered in the process of cartilage damage repair. This article mainly studied stem cells to promote the regeneration of knee joint degenerative bone articular cartilage. First, the animal articular cartilage defect is modeled, 10 ml of animal venous blood is drawn

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34

Enomura, Masahiro, Soichiro Murata, Yuri Terado, Maiko Tanaka, Shinji Kobayashi, Takayoshi Oba, Shintaro Kagimoto, et al. "Development of a Method for Scaffold-Free Elastic Cartilage Creation." International Journal of Molecular Sciences 21, no. 22 (November 11, 2020): 8496. http://dx.doi.org/10.3390/ijms21228496.

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Microtia is a congenital aplasia of the auricular cartilage. Conventionally, autologous costal cartilage grafts are collected and shaped for transplantation. However, in this method, excessive invasion occurs due to limitations in the costal cartilage collection. Due to deformation over time after transplantation of the shaped graft, problems with long-term morphological maintenance exist. Additionally, the lack of elasticity with costal cartilage grafts is worth mentioning, as costal cartilage is a type of hyaline cartilage. Medical plastic materials have been transplanted as alternatives to

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35

Kaplan, David. "Role of cartilage-forming cells in regenerative medicine for cartilage repair." Orthopedic Research and Reviews Volume 2 (September 2010): 85–94. http://dx.doi.org/10.2147/orr.s7194.

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36

Messaoudi, Océane, Christel Henrionnet, Kevin Bourge, Damien Loeuille, Pierre Gillet, and Astrid Pinzano. "Stem Cells and Extrusion 3D Printing for Hyaline Cartilage Engineering." Cells 10, no. 1 (December 22, 2020): 2. http://dx.doi.org/10.3390/cells10010002.

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Hyaline cartilage is deficient in self-healing properties. The early treatment of focal cartilage lesions is a public health challenge to prevent long-term degradation and the occurrence of osteoarthritis. Cartilage tissue engineering represents a promising alternative to the current insufficient surgical solutions. 3D printing is a thriving technology and offers new possibilities for personalized regenerative medicine. Extrusion-based processes permit the deposition of cell-seeded bioinks, in a layer-by-layer manner, allowing mimicry of the native zonal organization of hyaline cartilage. Mese

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Wang, Ketao, Ji Li, Zhongli Li, Bin Wang, Yuanyuan Qin, Ning Zhang, Hao Zhang, Xiangzheng Su, Yuxing Wang, and Heng Zhu. "Chondrogenic Progenitor Cells Exhibit Superiority Over Mesenchymal Stem Cells and Chondrocytes in Platelet-Rich Plasma Scaffold-Based Cartilage Regeneration." American Journal of Sports Medicine 47, no. 9 (June 13, 2019): 2200–2215. http://dx.doi.org/10.1177/0363546519854219.

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Background: Platelet-rich plasma (PRP) has been considered a promising tool for cartilage regeneration. However, increasing evidence has demonstrated the controversial effects of PRP on tissue regeneration, partially due to the unsatisfactory cell source. Chondrogenic progenitor cells (CPCs) have gained increasing attention as a potential cell source due to their self-renewal and multipotency, especially toward the chondrogenic lineage, and, thus, may be an appropriate alternative for cartilage engineering. Purpose: To compare the effects of PRP on CPC, mesenchymal stem cell (MSC), and chondro

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Chen, Yawen, Xinli Ouyang, Yide Wu, Shaojia Guo, Yongfang Xie, and Guohui Wang. "Co-culture and Mechanical Stimulation on Mesenchymal Stem Cells and Chondrocytes for Cartilage Tissue Engineering." Current Stem Cell Research & Therapy 15, no. 1 (March 19, 2020): 54–60. http://dx.doi.org/10.2174/1574888x14666191029104249.

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Defects in articular cartilage injury and chronic osteoarthritis are very widespread and common, and the ability of injured cartilage to repair itself is limited. Stem cell-based cartilage tissue engineering provides a promising therapeutic option for articular cartilage damage. However, the application of the technique is limited by the number, source, proliferation, and differentiation of stem cells. The co-culture of mesenchymal stem cells and chondrocytes is available for cartilage tissue engineering, and mechanical stimulation is an important factor that should not be ignored. A combinati

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39

Joe, Su Mee, In Seon Lee, Yong Tae Lee, Jun Hyuk Lee, and Byung Tae Choi. "Suppression of Collagen-Induced Arthritis in Rats by Continuous Administration of Dae-Bang-Poong-Tang (Da-Fang-Feng-Tang)." American Journal of Chinese Medicine 29, no. 02 (January 2001): 355–65. http://dx.doi.org/10.1142/s0192415x0100037x.

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Although Dae-Bang-Poong-Tang (an herbal formula of 15 herbs)-treated rats exhibited a mild inflammation, the significant histological changes including a marked infiltration of inflammatory cells in the synovium and damaged articular cartilages were not observed. The staining abilities of the cartilage such as periodic acid Schiff's reaction in the interterritorial matrix of hyaline cartilage, alcian blue and aldehyde fuchsin staining in the capsule of chondrocytes and in the interterritorial matrix of articular cartilage and Con A, sWGA and BSL-1 affinities of chondrocytes tended to decrease

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40

Li, Lu, Yuehui Ma, Xianglong Li, Xiangchen Li, Chunyu Bai, Meng Ji, Shuang Zhang, Weijun Guan, and Junjie Li. "Isolation, Culture, and Characterization of Chicken Cartilage Stem/Progenitor Cells." BioMed Research International 2015 (2015): 1–11. http://dx.doi.org/10.1155/2015/586290.

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A chondrocyte progenitor population isolated from the surface zone of articular cartilage has become a promising cell source for cell-based cartilage repair. The cartilage-derived stem/progenitor cells are multipotent stem cells, which can differentiate into three cell types in vitro including adipocytes, osteoblasts, and chondrocytes. Much work has been done on cartilage stem/progenitor cells (CSPCs) from people, horses, and cattle, but the relatively little literature has been published about these cells in chickens. In our work, CSPCs were isolated from chicken embryos in incubated eggs for

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41

Buhrmann, Constanze, Ali Honarvar, Mohsen Setayeshmehr, Saeed Karbasi, Mehdi Shakibaei, and Ali Valiani. "Herbal Remedies as Potential in Cartilage Tissue Engineering: An Overview of New Therapeutic Approaches and Strategies." Molecules 25, no. 13 (July 6, 2020): 3075. http://dx.doi.org/10.3390/molecules25133075.

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It is estimated that by 2023, approximately 20% of the population of Western Europe and North America will suffer from a degenerative joint disease commonly known as osteoarthritis (OA). During the development of OA, pro-inflammatory cytokines are one of the major causes that drive the production of inflammatory mediators and thus of matrix-degrading enzymes. OA is a challenging disease for doctors due to the limitation of the joint cartilage’s capacity to repair itself. Though new treatment approaches, in particular with mesenchymal stem cells (MSCs) that integrate the tissue engineering (TE)

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42

Shiraishi, Katsunori, Naosuke Kamei, Shunsuke Takeuchi, Shinobu Yanada, Hisashi Mera, Shigeyuki Wakitani, Nobuo Adachi, and Mitsuo Ochi. "Quality Evaluation of Human Bone Marrow Mesenchymal Stem Cells for Cartilage Repair." Stem Cells International 2017 (2017): 1–9. http://dx.doi.org/10.1155/2017/8740294.

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Quality evaluation of mesenchymal stem cells (MSCs) based on efficacy would be helpful for their clinical application. In this study, we aimed to find the factors of human bone marrow MSCs relating to cartilage repair. The expression profiles of humoral factors, messenger RNAs (mRNAs), and microRNAs (miRNAs) were analyzed in human bone marrow MSCs from five different donors. We investigated the correlations of these expression profiles with the capacity of the MSCs for proliferation, chondrogenic differentiation, and cartilage repair in vivo. The mRNA expression of MYBL1 was positively correla

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He, Yuan-Jia, Shuang Lin, and Qiang Ao. "Research Progress of Tissue-Engineered Cartilage in Repairing Cartilage Defects." Science of Advanced Materials 12, no. 1 (January 1, 2020): 66–74. http://dx.doi.org/10.1166/sam.2020.3704.

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Due to the unsatisfactory outcome of current clinical treatment, tissue engineering technology has become a promising approach for the treatment of cartilage defects. Typical cartilage tissue engineering uses seed cells that have been expanded in vitro to implant into various biomaterial scaffolds that are biocompatible and are gradually degraded and absorbed in the body, with or without physical/chemical factors mimicking the cartilage microenvironment, to regenerate cartilage tissue with similar biochemical and biomechanical properties to natural cartilage tissue. Therefore, we summarise the

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44

Cui, Dixin, Hongyu Li, Xin Xu, Ling Ye, Xuedong Zhou, Liwei Zheng, and Yachuan Zhou. "Mesenchymal Stem Cells for Cartilage Regeneration of TMJ Osteoarthritis." Stem Cells International 2017 (2017): 1–11. http://dx.doi.org/10.1155/2017/5979741.

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Temporomandibular joint osteoarthritis (TMJ OA) is a degenerative disease, characterized by progressive cartilage degradation, subchondral bone remodeling, synovitis, and chronic pain. Due to the limited self-healing capacity in condylar cartilage, traditional clinical treatments have limited symptom-modifying and structure-modifying effects to restore impaired cartilage as well as other TMJ tissues. In recent years, stem cell-based therapy has raised much attention as an alternative approach towards tissue repair and regeneration. Mesenchymal stem cells (MSCs), derived from the bone marrow, s

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45

Clark, Andrea L., Linda Mills, David A. Hart, and Walter Herzog. "MUSCLE-INDUCED PATELLOFEMORAL JOINT LOADING RAPIDLY AFFECTS CARTILAGE mRNA LEVELS IN A SITE SPECIFIC MANNER." Journal of Musculoskeletal Research 08, no. 01 (March 2004): 1–12. http://dx.doi.org/10.1142/s0218957704001223.

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Mechanical loading of articular cartilage affects the synthesis and degradation of matrix macromolecules. Much of the work in this area has involved mechanical loading of articular cartilage explants or cells in vitro and assessing biological responses at the mRNA and protein levels. In this study, we developed a new experimental technique to load an intact patellofemoral joint in vivo using muscle stimulation. The articular cartilages were cyclically loaded for one hour in a repeatable and measurable manner. Cartilage was harvested from central and peripheral regions of the femoral groove and

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46

Deng, Zhantao, Jiewen Jin, Jianning Zhao, and Haidong Xu. "Cartilage Defect Treatments: With or without Cells? Mesenchymal Stem Cells or Chondrocytes? Traditional or Matrix-Assisted? A Systematic Review and Meta-Analyses." Stem Cells International 2016 (2016): 1–14. http://dx.doi.org/10.1155/2016/9201492.

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Articular cartilage defects have been addressed by using multiple strategies. In the last two decades, promising new strategies by using assorted scaffolds and cell sources to induce tissue regeneration have emerged, such as autologous chondrocyte implantation (ACI) and mesenchymal stem cell implantation (MSCI). However, it is still controversial in the clinical strategies when to choose these treatments. Thus, we conducted a systematic review and meta-analyses to compare the efficacy and safety of different cartilage treatments. In our study, 17 studies were selected to compare different trea

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Huselstein, C., Y. Li, and X. He. "Mesenchymal stem cells for cartilage engineering." Bio-Medical Materials and Engineering 22, no. 1-3 (2012): 69–80. http://dx.doi.org/10.3233/bme-2012-0691.

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48

Min, Byoung-Hyun, Hyun Jung Lee, and Young Jick Kim. "Cartilage Repair Using Mesenchymal Stem Cells." Journal of the Korean Medical Association 52, no. 11 (2009): 1077. http://dx.doi.org/10.5124/jkma.2009.52.11.1077.

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Savkovic, Vuk, Hanluo Li, Jong-Keun Seon, Michael Hacker, Sandra Franz, and Jan-Christoph Simon. "Mesenchymal Stem Cells in Cartilage Regeneration." Current Stem Cell Research & Therapy 9, no. 6 (September 22, 2014): 469–88. http://dx.doi.org/10.2174/1574888x09666140709111444.

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Liao, Jinfeng, and Yunfeng Lin. "Stem Cells and Cartilage Tissue Engineering." Current Stem Cell Research & Therapy 13, no. 7 (August 29, 2018): 489. http://dx.doi.org/10.2174/1574888x1307180803122513.

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