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Tesis sobre el tema "Cisplatin"

Autor: Grafiati

Publicado: 4 de junio de 2021

Última modificación: 25 de julio de 2025

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1

Amaral, Catia Lira do. "Efeito do resveratrol na nefrotoxicidade induzida pela cisplatina em ratos." Universidade de São Paulo, 2006. http://www.teses.usp.br/teses/disponiveis/60/60134/tde-22052007-090133/.

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O resveratrol (Res), um polifenol presente no vinho tinto, é conhecido por possuir potente atividade antioxidante. O efeito do resveratrol (Res) frente à nefrotoxicidade do antineoplásico cisplatina (cDDP) foi avaliado em ratos neste estudo. Os animais foram tratados com Res (25 mg/Kg de peso copóreo, ip., dose única) 30 minutos antes da administração de cisplatina (5 mg/Kg de peso copóreo, ip., dose única) e foram sacrificados depois de 2 ou 5 dias do tratamento. Após 5 dias, o aumento da creatinina sérica, volume urinário e proteinúria, que são marcadores de alterações renais, apresentaram s

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2

Pan, Zhenrui. "Functional characterization of the GATOR1 complex in cisplatin resistance." Electronic Thesis or Diss., université Paris-Saclay, 2024. http://www.theses.fr/2024UPASL053.

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L'administration de cisplatine constitue la principale approche de chimiothérapie pour de nombreux cancers épithéliaux. Cependant, la résistance à ce médicament pose un défi considérable à un traitement efficace. Malgré l'identification de nombreux facteurs associés à la résistance aux médicaments, des biomarqueurs fiables permettant de prédire la réponse au traitement restent insaisissables. Auparavant, une faible expression du suppresseur de tumeur NPRL2 était liée à la résistance au cisplatine. NPRL2, ainsi que NPRL3 et DEPDC5, forment le complexe GATOR1, un régulateur en amont du complexe

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3

Santos, Graciela Cristina dos [UNESP]. "Avaliação do efeito protetor do urucum e da bixina sobre a genotoxicidade induzida pelo antitumoral cisplatina em células da linhagem PC12." Universidade Estadual Paulista (UNESP), 2008. http://hdl.handle.net/11449/100973.

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Made available in DSpace on 2014-06-11T19:31:05Z (GMT). No. of bitstreams: 0 Previous issue date: 2008-12-12Bitstream added on 2014-06-13T18:41:39Z : No. of bitstreams: 1 santos_gc_dr_arafcf.pdf: 2386901 bytes, checksum: b46aa55b36f051a8683831df1b69f150 (MD5)<br>Universidade Estadual Paulista (UNESP)<br>A neuropatia induzida por drogas quimioterápicas é uma complicação no tratamento do câncer e outras doenças por ser freqüentemente dolorosa e requerer a interrupção da terapia. O antitumoral cisplatina é comumente usado contra muitas formas de câncer há aproximadamente 40 anos. Entretanto, su

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Santos, Graciela Cristina dos. "Avaliação do efeito protetor do urucum e da bixina sobre a genotoxicidade induzida pelo antitumoral cisplatina em células da linhagem PC12 /." Araraquara : [s.n.], 2008. http://hdl.handle.net/11449/100973.

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Resumo: A neuropatia induzida por drogas quimioterápicas é uma complicação no tratamento do câncer e outras doenças por ser freqüentemente dolorosa e requerer a interrupção da terapia. O antitumoral cisplatina é comumente usado contra muitas formas de câncer há aproximadamente 40 anos. Entretanto, sua aplicação é associada a muitos efeitos tóxicos, como neurotoxicidade, nefrotoxicidade, perda da audição e vômitos. Estes efeitos adversos têm levado ao desenvolvimento de agentes específicos para amenizar a toxicidade do fármaco. Alguns estudos sugerem que a administração de antioxidantes é capaz

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5

Kullmann, Maximilian [Verfasser]. "Identifying intracellular cisplatin interaction partners and assessing their contribution to cisplatin resistance / Maximilian Kullmann." Bonn : Universitäts- und Landesbibliothek Bonn, 2016. http://d-nb.info/111988876X/34.

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6

Hadi, Sutopo. "The chemistry of cisplatin metabolites /." [St. Lucia, Qld.], 2007. http://www.library.uq.edu.au/pdfserve.php?image=thesisabs/absthe19800.pdf.

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7

Zhang, Jin-Gang. "Cisplatin nephrotoxicity : mechanisms and antidotes." Thesis, University of Liverpool, 1996. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.307635.

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8

Castro, João Humberto Teotônio de [UNESP]. "Avaliação do espermograma de cães submetidos à administração de cisplatina." Universidade Estadual Paulista (UNESP), 2007. http://hdl.handle.net/11449/89030.

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Made available in DSpace on 2014-06-11T19:23:42Z (GMT). No. of bitstreams: 0 Previous issue date: 2007-02-28Bitstream added on 2014-06-13T18:51:10Z : No. of bitstreams: 1 castro_jht_me_jabo.pdf: 401295 bytes, checksum: 5932eead976a77a78dee0fb6c3fb9169 (MD5)<br>Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)<br>A correta orientação do Médico Veterinário, aos proprietários de cães, usados com finalidades reprodutivas, submetidas à quimioterapia com cisplatina, é importante na medida que este agente citostático age nas células em constante divisão, podendo ser citotóxicos pa

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9

Oliva, Carlos Alfredo Calpa [UNESP]. "Hemograma e teores séricos de Na, K, Mg, Ca e P de cães hígidos submetidos à administração de cisplatina." Universidade Estadual Paulista (UNESP), 2007. http://hdl.handle.net/11449/89087.

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Made available in DSpace on 2014-06-11T19:23:43Z (GMT). No. of bitstreams: 0 Previous issue date: 2007-06-19Bitstream added on 2014-06-13T18:51:13Z : No. of bitstreams: 1 oliva_cac_me_jabo.pdf: 178983 bytes, checksum: f310a85e1eb63818fa51dba6cafeadd8 (MD5)<br>A cisplatina é um fármaco antineoplásico utilizado como adjuvante no tratamento de diversas neoplasias. Neste estudo foram avaliados o hemograma e os teores de sódio, potássio, magnésio, cálcio e fósforo do soro sanguíneo de cães submetidos à terapia com cisplatina. Foram utilizados oito cães, machos, sem raça definida, com 10 a 15 kg d

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10

Li, Yan Julia. "Cisplatin-induced cytotoxicity in MDCK cells." Thesis, University of Ottawa (Canada), 2002. http://hdl.handle.net/10393/6408.

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Background. The mechanism of cisplatin-induced nephrotoxicity is not well understood. The distal tubules are affected in both human and animal studies, although the majority of cisplatin-induced renal damage is in proximal tubules. Platinum (Pt) forms intra- and interstrand cross-links with DNA in cancer cells. Hypothesis. A mechanism of cisplatin-induced cytotoxicity in MDCK cells relates to its ability to bind to DNA and interfere with its synthesis. Methods. The canine distal renal tubular epithelial cell line, MDCK was used as an in vitro model to investigate the mechanism of cisplatin-ind

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11

Brock, Penelope. "Cisplatin toxicity in infants and children /." Leuven : Leuven University Press, 1994. http://www.gbv.de/dms/bs/toc/190814756.pdf.

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12

Holding, Jeremy David. "Cisplatin : protein binding and biological activity." Thesis, University of Liverpool, 1989. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.257185.

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13

Verma, Chandra Shekhar. "Modelling interactions between cisplatin and DNA." Thesis, University of York, 1990. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.238705.

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14

Baghai, Tabassom. "ATF3 as a Key Regulator of Cisplatin Cytotoxicity: Combining ATF3 Inducing Agents Enhances Cisplatin Activity in NSCLC." Thesis, Université d'Ottawa / University of Ottawa, 2018. http://hdl.handle.net/10393/37963.

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Lung cancer is the leading cause of cancer and cancer deaths worldwide, with non-small-cell lung carcinomas (NSCLC) representing 85% of all diagnosed lung cancers. Platinum-combination chemotherapy is the current standard treatment for NSCLC, however, associated toxicities and resistance limit its efficacy. Our laboratory previously identified activating transcription factor 3 (ATF3), a stress-inducible gene whose elevated and sustained expression can trigger apoptosis to a wide variety of stressors, as a key regulator of cisplatin cytotoxicity as well. Thus, enhanced and sustained induction o

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15

Romão, Marina Isabel Mendes. "Simulação de um modelo farmacocinético para a cisplatina." Master's thesis, [s.n.], 2012. http://hdl.handle.net/10284/3561.

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Trabalho apresentado à Universidade Fernando Pessoa como parte dos requisitos para obtenção do grau de Mestre em Ciências Farmacêuticas<br>A cisplatina é um dos fármacos mais utilizadas para tratar o cancro. A sua farmacocinética tem sido descrita por diversos modelos de compartimentos e de base fisiológica. Neste trabalho procurou demonstrar-se como o Excel© pode ser utilizado para simular o modelo mais utilizado para modelar a farmacocinética da cisplatina. A simulação em Excel© permitiu seguir a evolução temporal das concentrações de cisplatina e seus metabolitos em todos os tecidos do mo

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16

OLIVETTO, Elena. "IPOACUSIA NEUROSENSORIALE E DANNO ISCHEMICO. MESSA A PUNTO DI UN MODELLO ANIMALE PER VALUTARNE GLI EFFETTI VASCOLARI E OSSIDATIVI." Doctoral thesis, Università degli studi di Ferrara, 2013. http://hdl.handle.net/11392/2388913.

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Hearing impairment is an increasingly common disease. In Italy deaf people are about seven million, including half a million adults with disabling hearing loss and over one thousand births per year with congenital deafness. This causes difficulty in integration in society for adults and prevents the language acquisition for children (Fekete, 1999). As hearing loss has high social costs, the expectation for the development of new treatments is extensive and diseases leading to hearing damage are increasingly studied from clinic and base research. Hearing loss (HL) can have genetic causes,

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17

Singh, Tanya N. "Ru(II) complexes as photoactivated cisplatin analogs." Columbus, Ohio : Ohio State University, 2006. http://rave.ohiolink.edu/etdc/view?acc%5Fnum=osu1150391177.

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18

Dolling, Jo-Anna. "Cellular responses to ionizing radiation and cisplatin." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1998. http://www.collectionscanada.ca/obj/s4/f2/dsk2/ftp02/NQ28336.pdf.

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19

Ekborn, Andreas. "Cisplatin induced ototoxicity : pharmacokinetics, prediction and prevention /." Stockholm, 2003. http://diss.kib.ki.se/2003/91-7349-721-5.

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20

Pussegoda, Kusala. "The pharmacogenomics of cisplatin-induced hearing loss." Thesis, University of British Columbia, 2012. http://hdl.handle.net/2429/42203.

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Cisplatin is a widely used chemotherapeutic agent for the treatment of solid tumours. A serious complication of cisplatin treatment is permanent hearing loss. The study hypothesis is that genetic variants in genes involved in drug metabolism and transport can contribute to increased susceptibility to hearing loss in pediatric oncology patients treated with cisplatin. Patients were recruited from across Canada through the Canadian Pharmacogenomics Network for Drug Safety (CPNDS). Recently, our group identified several predictive genetic variants that were highly associated with cisplatin-indu

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21

Mantzavinou, Aikaterini. "Sustained-release implants for intraperitoneal cisplatin delivery." Thesis, Massachusetts Institute of Technology, 2018. http://hdl.handle.net/1721.1/120884.

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Thesis: Ph. D. in Medical Engineering, Harvard-MIT Program in Health Sciences and Technology, 2018.<br>Cataloged from PDF version of thesis.<br>Includes bibliographical references (pages 217-226).<br>The objective of this work was to develop materials for continuous low-dose delivery of cisplatin directly into the abdomen, also known as intraperitoneal (IP) chemotherapy. IP chemotherapy can help treat peritoneal metastasis in many advanced gynecologic and gastrointestinal cancers and has shown particular promise in treating advanced ovarian cancer. It is however tremendously underutilized beca

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22

Barnes, Katie R. 1978. "Mechanism-based rational design of cisplatin analogues." Thesis, Massachusetts Institute of Technology, 2005. http://hdl.handle.net/1721.1/33647.

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Thesis (Ph. D.)--Massachusetts Institute of Technology, Dept. of Chemistry, 2005.<br>Vita.<br>Includes bibliographical references.<br>The success of cisplatin as an anticancer drug is attributed to the ability of the platinum compound to damage DNA and subsequently induce apoptosis. Details of the cellular processing of cisplatin-damaged DNA can provide invaluable insight into the rational design of cisplatin analogues or combination therapies. Chapter I provides a survey of recent developments in the understanding of the mechanism of cisplatin action and summarizes relevant platinum-based ant

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23

Bhatta, Puspanjali. "Protective effect of capsaicin against cisplatin ototoxicity." OpenSIUC, 2014. https://opensiuc.lib.siu.edu/theses/1579.

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Cisplatin is a widely used chemotherapeutic drug for the treatment of solid tumors. However, the drug accumulates in the cochlea, and damages inner ear structures, resulting in bilateral andpermanent hearing loss. Previous data from our laboratory indicate that activation of the transient receptor potential vanilloid 1 (TRPV1) receptor (by capsaicin) increases the NOX3 isoform of NADPH oxidase, leading to the generation of reactive oxygen species (ROS) in the cochlea, transient cochlear inflammation and transient hearing loss. We also demonstrated that the transient inflammation was produced b

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24

Dantas, Marcos Vinicius Mendes. "Influência do quimioterápico Cisplatina sobre o reparo e mineralização ao redor de implantes dentários e sobre a qualidade do tecido ósseo : estudo mecânico e histométrico in vivo /." Araraquara, 2018. http://hdl.handle.net/11449/154089.

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Orientador: Marisa Aparecida Cabrini Gabrielli<br>Resumo: A maioria dos pacientes submetidos a tratamentos de câncer bucal são impossibilitados de receber reabilitação com próteses dentais convencionais. Assim, a confecção de próteses suportadas por implantes dentários osseointegráveis tem sido considerada uma alternativa. Apesar dos elevados índices de sucesso destes tratamentos, pode haver um inconveniente em se reabilitar esses pacientes. Alguns quimioterápicos, como a Cisplatina, apresentam efeitos colaterais como redução na remodelação óssea e/ou alteração na nutrição desse tecido, o que

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Gonçalves, Estela Maria. "Efeito da cisplatina em cultura de linhagens estabelecidas e sua capacidade de induzir transformação celular in vitro." [s.n.], 2005. http://repositorio.unicamp.br/jspui/handle/REPOSIP/317944.

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Orientador: Selma Candelaria Genari<br>Tese (doutorado) - Universidade Estadual de Campinas, Instituto de Biologia<br>Made available in DSpace on 2018-08-05T19:22:08Z (GMT). No. of bitstreams: 1 Goncalves_EstelaMaria_D.pdf: 4512893 bytes, checksum: 36b5b4604b23f405a7254a71f5971cd4 (MD5) Previous issue date: 2005<br>Resumo: A cisplatina é um agente antineoplásico utilizado no tratamento quimioterápico de tumores como os de testículo, de ovário e de bexiga urinária. Contudo, estudos indicam que a cisplatina apresenta potencial mutagênico, genotóxico e tumorigênico tanto in vitro como in vivo.

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26

Martins, Nádia Maria. "Avaliação do estresse oxidativo e estado redox mitocondrial na hepatotoxicidade induzida pela cisplatina em ratos \'Wistar\': efeito protetor da dimetiltiouréia." Universidade de São Paulo, 2007. http://www.teses.usp.br/teses/disponiveis/60/60134/tde-24072007-095608/.

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A cisplatina ainda é um dos agentes quimioterápicos mais efetivos. No entanto, em elevadas doses pode ocorrer hepatotoxicidade. Alguns antioxidantes têm sido mostrado amenizar a hepatotoxicidade induzida pela cisplatina mas o mecanismo molecular envolvido não está bem esclarecido.No presente estudo nós investigamos moleculares subjacente ao efeito protetor da dimetiltiuouréia (DMTU), um conhecido eqüestrador de radical hidroxil, contra a lesão oxidativamitocondrial hepática induzida pela cisplatina em ratos. Ratos Wistar machos adultos ( 200 a 220g) foram divididos entre 4 grupos de 8 animais

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27

Horáčková, Lucie. "Testování viability nádorových linií buněk po působení chemických látek a chemoterapeutik." Master's thesis, Vysoké učení technické v Brně. Fakulta chemická, 2018. http://www.nusl.cz/ntk/nusl-376847.

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Individual types of viability tests based on colorimetric changes of the solution are desribed in the theoretical part. Furthermore, HSP proteins are characterized, which are not connected only by heat shock, but also during other cell stresses such as exposure to UV, cold, extreme pH or heavy metals. They are important for the cell, because they help to reformulate proteins that have been damaged by cellular stress and also bind to new unpacked proteins and ensure their correct folding. Proteins that are affected by molecular chaperones are collectively called client proteins. Some HSPs also

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28

García, Rodríguez Francisco J. "Caenorhabditis elegans as animal model to investigate the cellular mechanism of resistance for the chemotherapeutic agent cisplatin." Doctoral thesis, Universitat de Barcelona, 2016. http://hdl.handle.net/10803/397787.

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In the last three decades, cisplatin has been one of the most widely prescribed drugs being an effective treatment for many cancer types. Despite its effectiveness, many patients are intrinsically resistant to cisplatin-based therapies and an important fraction of tumors eventually develop chemoresistance to this agent. In this study we consolidate C. elegans as a pluricellular model (I) to better understand the biological response to cisplatin-based chemotherapy to finally to map cellular pathways capable of modulating the response to cisplatin and (II) to functionally validate candidate gene

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29

Vernieux, Louise Winsome. "Cisplatin chemotherapy, the auditory verbal learning test, and the structure of memory /." [St. Lucia, Qld.], 1997. http://www.library.uq.edu.au/pdfserve.php?image=thesisabs/absthe17065.pdf.

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30

Kong, Bao. "THE ROLE AND REGULATION of MITOCHONDRIAL DYNAMICS IN CISPLATIN RESISTANCE IN HUMAN GYNECOLOGIC CANCER CELLS." Thesis, Université d'Ottawa / University of Ottawa, 2015. http://hdl.handle.net/10393/32461.

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Cervical cancer (CECA) and ovarian cancer (OVCA) rank first and third in the number of new cases diagnosed among gynecologic cancers，and chemoresistance severely limits their treatment success. The underlying mechanism of chemoresistance is multi-factorial and partly due to defects in drug-induced apoptosis. Cisplatinum (CDDP) -induced, p53-mediated mitochondrial cell death is controlled by Akt and is a determinant of chemosensitivity in gynecologic cancer cells. Mitochondria dynamics (fusion and fission) are involved in the regulation of mitochondria-mediated apoptosis. The tumor suppressor p

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31

DI, TELLA LUCIA. "Different p63 mediated response induced by doxorubicin and cisplatin: P63 activation by c-Abl in the cisplatin induced apoptotic pathway." Doctoral thesis, Università degli Studi di Roma "Tor Vergata", 2008. http://hdl.handle.net/2108/579.

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I membri della famiglia di p53 hanno funzioni simili e differenti. La proteina p53 è coinvolta nella risposta al danno al DNA provocando arresto del ciclo cellulare o apoptosi. Anche p73 induce arresto del ciclo cellulare o apoptosi dopo un danneggiamento del DNA. P63 è un membro della famiglia di p53 ma si conosce poco circa il suo ruolo nella risposta al danno al DNA e nel cancro. TAp63α è espresso negli oociti ed è essenziale per provocare la morte degli oociti in seguito al danneggiamento del DNA senza coinvolgere p53. Il danno al DNA induce il legame di p63 alle sequenze di DNA riconos

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Bulmer, J. Todd. "Cellular responses to the anti-cancer drug, cisplatin /." *McMaster only, 2001.

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Chu, Wendy. "Mechanism of cisplatin resistance in human malignant melanoma." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1999. http://www.collectionscanada.ca/obj/s4/f2/dsk3/ftp04/mq45534.pdf.

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Mandić, Aleksandra. "Elucidation of pro-apoptotic signaling induced by cisplatin /." Stockholm, 2003. http://diss.kib.ki.se/2003/91-7349-449-6.

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Salehi, Dermanaki Pezhman. "Prevention of cisplatin ototoxicity by curcumin loaded nanoparticles." Thesis, McGill University, 2014. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=121427.

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Cisplatin is an effective chemotherapeutic agent which causes oxidative and inflammatory damages to the cochlea, the hearing organ of the auditory system. The degenerative changes of the cochlea as a result of cisplatin chemotherapy lead to permanent hearing loss in patients, especially in younger children. Curcumin is a phytochemical compound known to exert various biological properties including acting as an effective antioxidant agent. In this study, curcumin was encapsulated by NIPAAM/VP/PEG-A nanoparticles to increase the bioavailability of the drug. Our hypothesis is that a combination t

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36

Odhah, M. S. "Cisplatin : Pharmacokinetic and biochemical studies in cancer patients." Thesis, Cardiff University, 1986. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.372341.

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Edlin, Angela Rosalyn Margaret. "DNA damage recognition and p53 in cisplatin resistance." Thesis, University of Glasgow, 1995. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.387598.

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Orton, David Michael. "Insights into the mode of action of cisplatin." Thesis, University of York, 1992. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.306541.

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39

He, Qing 1973. "Understanding and improving the anticancer activity of cisplatin." Thesis, Massachusetts Institute of Technology, 2001. http://hdl.handle.net/1721.1/44508.

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Thesis (Ph.D.)--Massachusetts Institute of Technology, Dept. of Chemistry, 2001.<br>Vita.<br>Includes bibliographical references.<br>The purpose of this thesis is to further our understanding of the mechanism of action of cis-diamminedichloroplatinum(II) (cisplatin), one of the most effective anticancer drugs. Since its serendipitous discovery in 1970, cisplatin has served to help cure testicular cancer and treat a variety of human malignancies. It is widely accepted that DNA is the cellular target for cisplatin. Prior to this work, several structures of duplex DNA modified by cisplatin reveal

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40

Fisher, Joshua. "In Vitro Binding Kinetics of ChemoFilter with Cisplatin." Thesis, University of California, San Francisco, 2016. http://pqdtopen.proquest.com/#viewpdf?dispub=10165379.

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<p> <b>Introduction:</b> Endovascular chemotherapy treatment allows localized delivery adjacent to the target tumor; allowing an increased dosage and decreased leakage to other areas. It also allows for the opportunity to filter chemotherapy escaping the target tumor and entering the bloodstream. The ChemoFilter - a temporarily deployable, endovascular device will do just that; reducing systemic toxicity thus reducing adverse side effects from chemotherapy treatment. This will allow further increased dosage, increased tumor suppression, and increased tolerance to treatment. ChemoFilter has suc

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41

Carroll, Eilis. "Investigation into ubiquitin signalling in response to cisplatin." Thesis, University of Dundee, 2014. https://discovery.dundee.ac.uk/en/studentTheses/bb2af7ef-0130-4eb7-8758-937e1a8e1824.

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Cisplatin is an anti-cancer drug that acts by introducing toxic DNA interstrand crosslinks into proliferating cells, causing both cytostatic and cytotoxic effects. Although various models of the interstrand crosslink (ICL) response have been proposed, none of them are complete and much still remains unknown about how this process is coordinated. By understanding more about how cisplatin and ICLs cause cell death, we may be able to optimise the use of current drugs, or identify novel targets for new chemotherapeutic drugs. It is known that ubiquitination is important for the regulation of the I

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42

Breaux, James Kelly. "Gene expression profiles indicative of response to cisplatin /." Diss., Connect to a 24 p. preview or request complete full text in PDF format. Access restricted to UC campuses, 2003. http://wwwlib.umi.com/cr/ucsd/fullcit?p3090455.

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Phelps, Jennifer Suzanne 1960. "CISPLATIN NEPHROTOXICITY: IN VITRO STUDIES (KIDNEY, TOXICOLOGY, PLATINUM)." Thesis, The University of Arizona, 1986. http://hdl.handle.net/10150/291243.

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SATHIYASEELAN, Theneshkumar. "Novel Oto-Protection Strategy in Cisplatin Induced Ototoxicity." Doctoral thesis, Università degli studi di Ferrara, 2009. http://hdl.handle.net/11392/2388666.

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It has been almost forty years since cisplatin was introduced in clinical practice as a potent and promising anti-neoplastic drug. Since then, the usage of cisplatin for treating a variety of cancers in both children and young adults has increased. Ototoxicity is one of the dose limiting side effects of cisplatin. Currently, there is not a single good otoprotecting drug against cisplatin ototoxicity in clinical practice. We planed to study the effect of noise stress against cisplatin ototoxicity alone and in combination with two other thiol based otoprotectors, namely L-NAC and D-MET, at

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Scaramel, Fernanda dos Santos. "Avaliação da inativação de cisplatina, doxorrubicina e paclitaxel utilizando soluções de asepto 75® 0,5%, hipoclorito de sódio 10% e tiossulfato de sódio 10%." Universidade de São Paulo, 2009. http://www.teses.usp.br/teses/disponiveis/9/9139/tde-26012017-112701/.

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Os agentes antineoplásicos são considerados drogas de risco, ou seja, aquelas que podem ocasionar efeitos como genotoxicidade, carcinogenicidade , teratogenicidade ou alteração na fertilidade e a exposição dos profissionais de saúde constitui-se em grande preocupação do ponto de vista de saúde ocupacional. Precedendo o seu emprego na terapia oncológica, estes medicamentos devem ser submetidos a análises físicas, químicas e biológicas para avaliação da qualidade, sendo que estes testes geram considerável volume de resíduos que também requerem tratamento. O objetivo deste trabalho foi avaliar a

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Mendonça, Leonardo Meneghin. "Avaliação genotóxia e antigenotóxica da curcumina contra a toxicidade induzida pela cisplatina em culturas de células PC12." Universidade de São Paulo, 2008. http://www.teses.usp.br/teses/disponiveis/60/60134/tde-14092008-220103/.

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Pode-se dizer que o câncer, ao lado da AIDS, é a doença que atinge, a níveis mundiais, maior clamor da sociedade por desenvolvimento de cura e melhor qualidade de vida ao paciente. Várias terapias são utilizadas para o tratamento do câncer, podendo-se destacar a importância da quimioterapia em inúmeros protocolos de tratamento. Um dos fármacos mais antigos e mais utilizados na quimioterapia é a cisplatina, que ao longo dos seus mais de 30 anos na prática clínica demonstrou sua eficácia e foi incorporada no protocolo de tratamento de uma variedade de tumores. Entretanto, ao lado se sua comprova

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Machado, Carla da Silva. "Possíveis efeitos citoprotetores do antioxidante da dieta coenzima Q10 em modelo de células neuronais." Universidade de São Paulo, 2011. http://www.teses.usp.br/teses/disponiveis/60/60134/tde-24102011-143836/.

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A coenzima Q10 é uma provitamina lipossolúvel sintetizada endogenamente e naturalmente encontrada em alimentos como a carne vermelha, peixes, cereais, brócolis e espinafre. É comercializada como suplemento alimentar e utilizada em formulações cosméticas. Localiza-se na membrana de organelas celulares como retículo endoplasmático, vesículas e membrana interna da mitocôndria, onde atua como um cofator essencial na cadeia respiratória. Apresenta propriedades antioxidantes e potencial no tratamento de doenças neurodegenerativas e neuromusculares. O objetivo deste trabalho foi investigar os possíve

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Robey, Stephanie. "Reactions of Platinum(II) Compounds with Selenium Containing Amino Acids." TopSCHOLAR®, 2013. http://digitalcommons.wku.edu/theses/1252.

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Platinum(II) anticancer medications essentially react with DNA forming kinks inthe double helix of DNA and causing apoptosis. It has also been noted that theseanticancer medications react with methionine and cysteine in the body. With the new discoveries of selenium containing amino acids including selenomethionine and selenocysteine, new research is ongoing to see what types of products can be formed from these amino acids. Our research reacts [Pt(Met-S,N)Cl2] 2+ with selenomethionine to determine what types of products are produced. Monochelates including [Pt(SeMet-Se,N)Cl2] 2+ have formed t

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Chau, Quincy Ka-Hing. "Cisplatin efflux, binding and intracellular pH in the HTB56 human lung adenocarcinoma cell line and the E-8/0.7 cisplatin-resistant variant." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1999. http://www.collectionscanada.ca/obj/s4/f2/dsk1/tape9/PQDD_0005/MQ46559.pdf.

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Menardo, Julien. "Effets des dommages de l'ADN et du stress oxydant sur la dégénérescence des structures neuroépithéliales de la cochlée lors de l'intoxication au cisplatine et au cours du vieillissement." Thesis, Montpellier 1, 2013. http://www.theses.fr/2013MON1T012.

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Dans nos sociétés modernes, la presbyacousie, perte de l'audition liée au vieillissement, prend une place de plus en plus importante. Outre le vieillissement de la population, la prévalence de la presbyacousie est accentuée par l'exposition à des bruits toujours plus forts (concerts, baladeurs, environnement de travail, ...) et la prise de médicaments ototoxiques (cisplatine, aminoglycosides, ...). À ce jour, le lien entre l'endommagement de l'ADN, le stress oxydant et l'inflammation avec l'apparition précoce de certaines maladies liées au vieillissement (Alzheimer, démence, Parkinson, …) a ét

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