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Artículos de revistas sobre el tema "Corneal epithelial cells"

Autor: Grafiati

Publicado: 4 de junio de 2021

Última modificación: 21 de febrero de 2023

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1

Langer, Marian G., C. V. Sundarraj, and Nirmala Sundarraj. "Corneal epithelial-specific cell surface antigen recognized by a monoclonal antibody." Development 94, no. 1 (June 1, 1986): 163–72. http://dx.doi.org/10.1242/dev.94.1.163.

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Monoclonal antibodies, specific against cell surface differentiation antigens of human corneal epithelial cells, were developed using epithelial cells resected from human corneas as the immunogens. One of these antibodies reacted specifically with corneal epithelial cells and not with epithelial cells of other tissues when tested by an indirect immunoperoxidase technique. Nonidet P-40 extracts of different subcellular fractions of human corneal epithelial cells were tested for their reactivity against this antibody using an enzyme-linked immunosorbent assay. The results indicated that the anti

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2

Alarcon, Irania, Lesley Kwan, Chong Yu, David J. Evans, and Suzanne M. J. Fleiszig. "Role of the Corneal Epithelial Basement Membrane in Ocular Defense against Pseudomonas aeruginosa." Infection and Immunity 77, no. 8 (June 8, 2009): 3264–71. http://dx.doi.org/10.1128/iai.00111-09.

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ABSTRACT Pseudomonas aeruginosa can invade corneal epithelial cells and translocates multilayered corneal epithelia in vitro, but it does not penetrate the intact corneal epithelium in vivo. In healthy corneas, the epithelium is separated from the underlying stroma by a basement membrane containing extracellular matrix proteins and pores smaller than bacteria. Here we used in vivo and in vitro models to investigate the potential of the basement membrane to defend against P. aeruginosa. Transmission electron microscopy of infected mouse corneas in vivo showed penetration of the stroma by P. aer

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3

Hazlett, L. D., and P. Mathieu. "Glycoconjugates on corneal epithelial surface: effect of neuraminidase treatment." Journal of Histochemistry & Cytochemistry 37, no. 8 (August 1989): 1215–24. http://dx.doi.org/10.1177/37.8.2754252.

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The purpose of this study was to develop a procedure to quantitatively examine corneal epithelial apical cell membrane-associated glycoconjugates. Saccharide moieties on young, mature, and aged corneal epithelial cells were detected and localized in corneas of immature and adult mice by using colloidal gold-labeled lectins and transmission electron microscopy (TEM). In general, dense binding to the corneal epithelial apical surface cell membranes with wheat germ agglutinin (WGA) was seen in the adult, whereas the immature cornea bound less WGA-gold. Neuraminidase digestion decreased binding of

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4

Augustin, Danielle K., Susan R. Heimer, Connie Tam, Wing Y. Li, Jeff M. Le Due, David J. Evans, and Suzanne M. J. Fleiszig. "Role of Defensins in Corneal Epithelial Barrier Function againstPseudomonas aeruginosaTraversal." Infection and Immunity 79, no. 2 (November 29, 2010): 595–605. http://dx.doi.org/10.1128/iai.00854-10.

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ABSTRACTStudies have shown that epithelium-expressed antimicrobial peptides (AMPs), e.g., β-defensins, play a role in clearing bacteria from mouse corneas already infected withPseudomonas aeruginosa. Less is known about the role of AMPs in allowing the cornea to resist infection when healthy. We previously reported that contact lens exposure, a major cause ofP. aeruginosakeratitis, can inhibit the upregulation of human β-defensin 2 (hBD-2) by corneal epithelial cells in response toP. aeruginosaantigensin vitro. Here, we studied the role of AMPs in maintaining the corneal epithelial barrier toP

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5

Zieske, J. D., and M. Wasson. "Regional variation in distribution of EGF receptor in developing and adult corneal epithelium." Journal of Cell Science 106, no. 1 (September 1, 1993): 145–52. http://dx.doi.org/10.1242/jcs.106.1.145.

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Epidermal growth factor receptor has been localized to the proliferative cell layers in a variety of stratified squamous epithelia. In the current study, the rat cornea was used as an experimental model to determine if epidermal growth factor receptor is concentrated in epithelial stem cells. Epidermal growth factor receptor was localized using immunofluorescence microscopy in adult and neonatal (1-day to 4-week) rat corneas. Antibody binding to epidermal growth factor receptor was present in basal cells across the adult cornea but was more intense in the limbal zone. In rats 1 day to 1 week o

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6

Park, Mijeong, Alexander Richardson, Elvis Pandzic, Erwin P. Lobo, J. Guy Lyons, and Nick Di Girolamo. "Peripheral (not central) corneal epithelia contribute to the closure of an annular debridement injury." Proceedings of the National Academy of Sciences 116, no. 52 (December 16, 2019): 26633–43. http://dx.doi.org/10.1073/pnas.1912260116.

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Corneal epithelia have limited self-renewal and therefore reparative capacity. They are continuously replaced by transient amplifying cells which spawn from stem cells and migrate from the periphery. Because this view has recently been challenged, our goal was to resolve the conflict by giving mice annular injuries in different locations within the corneolimbal epithelium, then spatiotemporally fate-mapping cell behavior during healing. Under these conditions, elevated proliferation was observed in the periphery but not the center, and wounds predominantly resolved by centripetally migrating l

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7

Han, Sang Beom, Farah Nur Ilyana Mohd Ibrahim, Yu-Chi Liu, and Jodhbir S. Mehta. "Efficacy of Modified Amnion-Assisted Conjunctival Epithelial Redirection (ACER) for Partial Limbal Stem Cell Deficiency." Medicina 57, no. 4 (April 10, 2021): 369. http://dx.doi.org/10.3390/medicina57040369.

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Background and objectives: the aim of this study was to analyze the efficacy of a modified “amnion-assisted conjunctival epithelial redirection (ACER)” technique for the treatment of partial limbal stem cell deficiency (LSCD). Materials and methods: the medical records of three patients with partial LSCD who underwent corneal surface reconstruction with modified ACER following superficial keratectomy were retrospectively studied. Briefly, in this technique, an inner amniotic membrane (AM) layer was applied on the corneal surface to promote corneal re-epithelialization. The outer AM layer was a

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8

Ryu, Jin Suk, So Yeon Kim, Mee Kum Kim, and Joo Youn Oh. "Inflammation Confers Healing Advantage to Corneal Epithelium following Subsequent Injury." International Journal of Molecular Sciences 24, no. 4 (February 7, 2023): 3329. http://dx.doi.org/10.3390/ijms24043329.

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Recent evidence shows that epithelial stem/progenitor cells in barrier tissues such as the skin, airways and intestines retain a memory of previous injuries, which enables tissues to accelerate barrier restoration after subsequent injuries. The corneal epithelium, the outermost layer of the cornea, is the frontline barrier for the eye and is maintained by epithelial stem/progenitor cells in the limbus. Herein, we provide evidence that inflammatory memory also exists in the cornea. In mice, eyes that had been exposed to corneal epithelial injury exhibited faster re-epithelialization of the corn

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9

Schermer, A., S. Galvin, and T. T. Sun. "Differentiation-related expression of a major 64K corneal keratin in vivo and in culture suggests limbal location of corneal epithelial stem cells." Journal of Cell Biology 103, no. 1 (July 1, 1986): 49–62. http://dx.doi.org/10.1083/jcb.103.1.49.

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In this paper we present keratin expression data that lend strong support to a model of corneal epithelial maturation in which the stem cells are located in the limbus, the transitional zone between cornea and conjunctiva. Using a new monoclonal antibody, AE5, which is highly specific for a 64,000-mol-wt corneal keratin, designated RK3, we demonstrate that this keratin is localized in all cell layers of rabbit corneal epithelium, but only in the suprabasal layers of the limbal epithelium. Analysis of cultured corneal keratinocytes showed that they express sequentially three major keratin pairs

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10

Bardag-Gorce, Fawzia, Alissa Diaz, Robert Niihara, Jeremy Stark, Daileen Cortez, Alexander Lee, Richard Hoft, and Yutaka Niihara. "Aldehyde Dehydrogenases Expression in Corneal Epithelial Cells with Limbal Stem Cell Deficiency." International Journal of Molecular Sciences 23, no. 7 (April 5, 2022): 4032. http://dx.doi.org/10.3390/ijms23074032.

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Purpose: The purpose of the present study is to investigate the expression of aldehyde dehydrogenases (ALDHs) in rabbit corneas with limbal stem cell deficiency (LSCD) and corneas treated with cultured autologous oral mucosa epithelial cell sheet CAOMECS designed to reconstruct the ocular surface with LSCD. Methods: New Zealand white rabbit autologous oral mucosal epithelial cells were isolated from a buccal biopsy and cultured to be grafted back onto corneas of rabbit model of LSCD. Immunofluorescent staining and Western blot analysis were used to compare the expression of ALDH1A1 and ALDH1A3

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11

Findlay, Amy S., D. Alessio Panzica, Petr Walczysko, Amy B. Holt, Deborah J. Henderson, John D. West, Ann M. Rajnicek, and J. Martin Collinson. "The core planar cell polarity gene, Vangl2 , directs adult corneal epithelial cell alignment and migration." Royal Society Open Science 3, no. 10 (October 2016): 160658. http://dx.doi.org/10.1098/rsos.160658.

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This study shows that the core planar cell polarity (PCP) genes direct the aligned cell migration in the adult corneal epithelium, a stratified squamous epithelium on the outer surface of the vertebrate eye. Expression of multiple core PCP genes was demonstrated in the adult corneal epithelium. PCP components were manipulated genetically and pharmacologically in human and mouse corneal epithelial cells in vivo and in vitro . Knockdown of VANGL2 reduced the directional component of migration of human corneal epithelial (HCE) cells without affecting speed. It was shown that signalling through PC

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12

Pino, Christopher J., Frederick R. Haselton, and Min S. Chang. "Seeding of Corneal Wounds by Epithelial Cell Transfer from Micropatterned PDMS Contact Lenses." Cell Transplantation 14, no. 8 (September 2005): 565–71. http://dx.doi.org/10.3727/000000005783982783.

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Persistent corneal wounds result from numerous eye disorders, and to date, available treatments often fail to accelerate reepithelialization, the key initial step in wound healing. To speed reepithelialization, we explored a cell-transfer transplant method utilizing polydimethylsiloxane (PDMS) contact lenses to deliver epithelial cells derived from limbal explants directly within a corneal wound. Human primary epithelial cells and an immortalized corneal epithelial cell line (HCE-SV40) grew well on PDMS contact lenses and their morphology and growth rates where similar to cells grown on tissue

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13

Becker, Ulrich, Carsten Ehrhardt, Marc Schneider, Leon Muys, Dorothea Gross, Klaus Eschmann, Ulrich F. Schaefer, and Claus-Michael Lehr. "A Comparative Evaluation of Corneal Epithelial Cell Cultures for Assessing Ocular Permeability." Alternatives to Laboratory Animals 36, no. 1 (February 2008): 33–44. http://dx.doi.org/10.1177/026119290803600106.

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The purpose of this study was to evaluate the potential value of different epithelial cell culture systems as in vitro models for studying corneal permeability. Transformed human corneal epithelial (HCE-T) cells and Statens Serum Institut rabbit corneal (SIRC) cells were cultured on permeable filters. SkinEthic human corneal epithelium (S-HCE) and Clonetics human corneal epithelium (C-HCE) were received as ready-to-use systems. Excised rabbit corneas (ERCs) and human corneas (EHCs) were mounted in Ussing chambers, and used as references. Barrier properties were assessed by measuring transepith

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14

Musayeva, Aytan, Caroline Manicam, Andreas Steege, Christoph Brochhausen, Beate K. Straub, Katharina Bell, Norbert Pfeiffer та Adrian Gericke. "Role of α1-adrenoceptor subtypes on corneal epithelial thickness and cell proliferation in mice". American Journal of Physiology-Cell Physiology 315, № 5 (1 листопада 2018): C757—C765. http://dx.doi.org/10.1152/ajpcell.00314.2018.

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Adrenergic stimuli are important for corneal epithelial structure and healing. The purpose of the present study was to examine the hypothesis that the lack of a single α1-adrenoceptor (α1-AR) subtype affects corneal epithelial thickness and cell proliferation. Expression levels of α1-AR mRNA were determined in mouse cornea using real-time PCR. In mice devoid of one of the three α1-AR subtypes (α1A-AR−/−, α1B-AR−/−, α1D-AR−/−) and in wild-type controls, thickness of individual corneal layers, the number of epithelial cell layers, and average epithelial cell size were determined in cryosections.

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15

Nuzzi, Alessia, Francesco Pozzo Giuffrida, Saverio Luccarelli, and Paolo Nucci. "Corneal Epithelial Regeneration: Old and New Perspectives." International Journal of Molecular Sciences 23, no. 21 (October 28, 2022): 13114. http://dx.doi.org/10.3390/ijms232113114.

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Corneal blindness is the fifth leading cause of blindness worldwide, and therapeutic options are still often limited to corneal transplantation. The corneal epithelium has a strong barrier function, and regeneration is highly dependent on limbal stem cell proliferation and basement membrane remodeling. As a result of the lack of corneal donor tissues, regenerative medicine for corneal diseases affecting the epithelium is an area with quite advanced basic and clinical research. Surgery still plays a prominent role in the treatment of epithelial diseases; indeed, innovative surgical techniques h

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16

Wang, Fan, Bo Ren, and Yi Ning Yan. "Stem Cell-Like Characteristics of Corneal Epithelial Cells." Advanced Materials Research 998-999 (July 2014): 312–15. http://dx.doi.org/10.4028/www.scientific.net/amr.998-999.312.

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Purpose: The adult corneal epithelium is maintained by a population of limbal stem cells (LSCs), transmembrane protein prominin, regarded as stem cell marker was investigated on mouse corneal tissue, to study weather contains CD133-expressing cells and their distribution. Methods: Enucleated mouse eyes were embedded in OCT and cryosections were performed for mmunohistochemical studies using the avidin-biotin-peroxidase complex (ABC) procedure. Meanwhile, dissected mouse corneas were analyzed by westernblot. Results: In the adult mouse, 13A4 immunoreactivity was detected at the apical side of s

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17

Liu, Cong, Xin Yu, and Yun Kou. "Effect of diagnostic ultrasound on corneal apoptosis in rats." Tropical Journal of Pharmaceutical Research 19, no. 9 (November 24, 2020): 1947–51. http://dx.doi.org/10.4314/tjpr.v19i9.21.

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Purpose: To investigate the effect of diagnostic ultrasound on corneal apoptosis in rats.Methods: 24 male rats were randomly divided into 4 groups: control group, 10, 20 and 30 min group. The eyeballs of rats were irradiated continuously for different time lengths by Siemens ACUSON S2000 color Doppler ultrasound diagnostic instrument. 24 hours later, the animals were killed and the corneas were taken for Tunel apoptosis detection. The apoptosis rates of corneal epithelial cells, stromal cells and endothelial cells were calculated.Results: Apoptotic cells were detected in corneal epithelial cel

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18

Notara, M., A. Lentzsch, M. Coroneo, and C. Cursiefen. "The Role of Limbal Epithelial Stem Cells in Regulating Corneal (Lymph)angiogenic Privilege and the Micromilieu of the Limbal Niche following UV Exposure." Stem Cells International 2018 (2018): 1–15. http://dx.doi.org/10.1155/2018/8620172.

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The cornea is a clear structure, void of blood, and lymphatic vessels, functioning as our window to the world. Limbal epithelial stem cells, occupying the area between avascular cornea and vascularized conjunctiva, have been implicated in tissue border maintenance, preventing conjunctivalisation and propagation of blood and lymphatic vessels into the cornea. Defects in limbal epithelial stem cells are linked to corneal neovascularisation, including lymphangiogenesis, chronic inflammation, conjunctivalisation, epithelial abnormalities including the presence of goblet cells, breaks in Bowman’s m

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19

Krasnov, M. S., and V. P. Yamskova. "The Effect of Bioregulators Isolated from Blood Serum and Cornea of the Bovin’s Eye on the Condition of Tissue and Cells of the Rabbit Corneas during Cultivation and Storage." Ophthalmology in Russia 18, no. 3 (October 1, 2021): 488–94. http://dx.doi.org/10.18008/1816-5095-2021-3-488-494.

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Objective: to study the condition of the cornea, as well as its epithelial and endothelial cells, while maintaining in vitro at various temperature conditions, under the influence of a number of factors, including bioregulators isolated from blood serum and cornea of the bovine, and epidermal growth factor.Methods. The study was carried out on rabbit corneas stored at temperatures of +4, –86 °C, as well as the cultivation of endothelial and epithelial cells isolated from the cornea after storage at these temperatures, followed by histological and immunohistochemical studies.Results. Storage of

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20

Morii, Tomoya, Takayoshi Sumioka, Ai Izutani-Kitano, Yukihisa Takada, Yuka Okada, Winston W. Y. Kao, and Shizuya Saika. "A Case of Solitary Nonvascularized Corneal Epithelial Dysplasia." Case Reports in Ophthalmological Medicine 2016 (2016): 1–4. http://dx.doi.org/10.1155/2016/5687285.

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Background. Epithelial dysplasia is categorized as conjunctival/corneal intraepithelial neoplasia which is a precancerous lesion. The lesion is usually developed at the limbal region and grows towards central cornea in association with neovascularization into the lesion. Here, we report a case of isolated nonvascularized corneal epithelial dysplasia surrounded by normal corneal epithelium with immune histochemical finding of ocular surface tissues cytokeratins, for example, keratin 13 and keratin 12.Case Presentation. A 76-year-old man consulted us for visual disturbance with localized opacifi

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21

Cui, Hao, Ying Liu, and Yifei Huang. "Roles of TRIM32 in Corneal Epithelial Cells After Infection with Herpes Simplex Virus." Cellular Physiology and Biochemistry 43, no. 2 (2017): 801–11. http://dx.doi.org/10.1159/000481563.

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Background: Epithelial cells play important roles as a critical barrier in protecting the cornea from microbial pathogens infection. Methods: In this study, we were aiming to investigate the role of E3 ubiquitin ligase tripartite motif protein 32 (TRIM32) in corneal epithelial cells in response to Herpes Simplex Virus type 1 (HSV-1) infection and to elucidate the underlying mechanisms. Results: We found the expression of TRIM32 was increased after infected with HSV-1 both in murine corneas and cultured human epithelial (HCE) cells. Furthermore, knockdown of the expression of TRIM32 significant

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22

Pedrotti, Emilio, Chiara Chierego, Tiziano Cozzini, Tommaso Merz, Neil Lagali, Alessandra De Gregorio, Adriano Fasolo, Erika Bonacci, Jacopo Bonetto, and Giorgio Marchini. "In Vivo Confocal Microscopy of the Corneal-Conjunctival Transition in the Evaluation of Epithelial Renewal after SLET." Journal of Clinical Medicine 9, no. 11 (November 6, 2020): 3574. http://dx.doi.org/10.3390/jcm9113574.

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Examination of the corneal surface by in vivo confocal microscopy (IVCM) allows for objective identification of corneal and conjunctival cell phenotypes to evaluate different epithelialization patterns. Detection of a corneal-conjunctival epithelial transition could be considered as a sign of restored epithelial function following simple limbal epithelial transplantation (SLET). This is a prospective, interventional case series. We assessed patients with limbal stem cell deficiency (LSCD) by IVCM, preoperatively and at monthly intervals following SLET. Sectors in the central and peripheral cor

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23

Sangwan, Virender S. "Limbal Stem Cells in Health and Disease." Bioscience Reports 21, no. 4 (August 1, 2001): 385–405. http://dx.doi.org/10.1023/a:1017935624867.

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Stem cells are present in all self-reviewing tissues and have unique properties. The ocular surface is made up of two distinct types of epithelial cells, constituting the conjunctival and the corneal epithelia. These epithelia are stratified, squamous and non-keratinized. Although anatomically continuous with each other at the corneoscleral limbus, the two cell phenotypes represent quite distinct subpopulations. The stem cells for the cornea are located at the limbus. The microenvironment of the limbus is considered to be important in maintaining stemness of the stem cells. They also act as a

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Nguyen, Hong Thi, Kasem Theerakittayakorn, Sirilak Somredngan, Apichart Ngernsoungnern, Piyada Ngernsoungnern, Pishyaporn Sritangos, Mariena Ketudat-Cairns, et al. "Signaling Pathways Impact on Induction of Corneal Epithelial-like Cells Derived from Human Wharton’s Jelly Mesenchymal Stem Cells." International Journal of Molecular Sciences 23, no. 6 (March 12, 2022): 3078. http://dx.doi.org/10.3390/ijms23063078.

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Corneal epithelium, the outmost layer of the cornea, comprises corneal epithelial cells (CECs) that are continuously renewed by limbal epithelial stem cells (LESCs). Loss or dysfunction of LESCs causes limbal stem cell deficiency (LSCD) which results in corneal epithelial integrity loss and visual impairment. To regenerate the ocular surface, transplantation of stem cell-derived CECs is necessary. Human Wharton’s jelly derived mesenchymal stem cells (WJ-MSCs) are a good candidate for cellular therapies in allogeneic transplantation. This study aimed to test the effects of treatments on three s

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Xie, Ruo Zhong, Serina Stretton, and Deborah F. Sweeney. "Artificial Cornea: Towards a Synthetic Onlay for Correction of Refractive Error." Bioscience Reports 21, no. 4 (August 1, 2001): 513–36. http://dx.doi.org/10.1023/a:1017900111663.

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Synthetic onlays that are implanted onto the surface of the cornea have the potential to become an alternative to spectacles and contact lenses for the correction of refractive error. A successful corneal onlay is dependent on development of a biocompatible polymer material that will maintain a healthy cornea after implantation and that will promote growth of corneal epithelial cells over the onlay, and development of a method for attachment of the onlay with minimal surgical invasiveness. The ideal onlay should be made of a material that is highly permeable yet has sufficient surface characte

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Lee, Hyo Kyung, Jin Suk Ryu, Hyun Jeong Jeong, Mee Kum Kim, and Joo Youn Oh. "Protection of Corneal Limbus from Riboflavin Prevents Epithelial Stem Cell Loss after Collagen Cross-Linking." Journal of Ophthalmology 2018 (June 3, 2018): 1–7. http://dx.doi.org/10.1155/2018/6854298.

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Purpose. To investigate whether the protection of corneal limbus from riboflavin exposure during collagen cross-linking (CXL) prevents limbal epithelial stem cell (LESC) loss. Methods. Ten New Zealand white rabbits received an epithelium-off CXL using an accelerated protocol. Seven days before procedure, 5-bromo-2-deoxyuridine (BrdU) was intraperitoneally injected. During procedure, riboflavin was applied to the corneal surface within a 9 mm diameter retention ring in 5 rabbits, thereby preventing the limbus from riboflavin exposure. In other 5 rabbits, riboflavin was instilled every 2 min, al

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27

Leher, Henry, Robert Silvany, Hassan Alizadeh, Jing Huang, and Jerry Y. Niederkorn. "Mannose Induces the Release of Cytopathic Factors from Acanthamoeba castellanii." Infection and Immunity 66, no. 1 (January 1, 1998): 5–10. http://dx.doi.org/10.1128/iai.66.1.5-10.1998.

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ABSTRACT Acanthamoeba keratitis is a chronic inflammatory disease of the cornea which is highly resistant to many antimicrobial agents. The pathogenic mechanisms of this disease are poorly understood. However, it is believed that the initial phases in the pathogenesis of Acanthamoeba keratitis involve parasite binding and lysis of the corneal epithelium. These processes were examined in vitro, usingAcanthamoeba castellanii trophozoites. Parasites readily adhered to Chinese hamster corneal epithelial cells in vitro; however, parasite binding was strongly inhibited by mannose but not by lactose.

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Saban, Daniel, Taakaki Hattori, Sunil Chauhan, and Reza Dana. "Identification and characterization of langerin positive dendritic cells in the normal cornea and in transplantation. (145.27)." Journal of Immunology 184, no. 1_Supplement (April 1, 2010): 145.27. http://dx.doi.org/10.4049/jimmunol.184.supp.145.27.

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Abstract A novel population of migratory dendritic cells (DCs), distinct from Langerhans cells (LC), was recently found to which also express langerin (CD207+) and reside throughout the body (skin, lung, gut, and liver). Moreover, such CD207+ DCs were shown to be important in generating immunity. Thus, we investigated whether CD207+ DCs exist in the cornea and their possible migration to lymph nodes (LN) in corneal alloimmunity. Methods: C57BL/6 corneas (n=30) were collected and epithelium separated from stroma. Tissue was pooled separately and digested enzymatically for FACS analysis of CD45,

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Kacham, Santhosh, Tejal Sunil Bhure, Sindhuja D. Eswaramoorthy, Gaurav Naik, Subha Narayan Rath, Sreenivasa Rao Parcha, Sayan Basu, Virender Singh Sangwan, and Sachin Shukla. "Human Umbilical Cord-Derived Mesenchymal Stem Cells Promote Corneal Epithelial Repair In Vitro." Cells 10, no. 5 (May 19, 2021): 1254. http://dx.doi.org/10.3390/cells10051254.

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Corneal injuries are among the leading causes of blindness and vision impairment. Trauma, infectious keratitis, thermal and chemical (acids and alkali burn) injuries may lead to irreversible corneal scarring, neovascularization, conjunctivalization, and limbal stem cell deficiency. Bilateral blindness constitutes 12% of total global blindness and corneal transplantation remains a stand-alone treatment modality for the majority of end-stage corneal diseases. However, global shortage of donor corneas, the potential risk of graft rejection, and severe side effects arising from long-term use of im

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30

Ramos, Tiago, Deborah Scott, and Sajjad Ahmad. "An Update on Ocular Surface Epithelial Stem Cells: Cornea and Conjunctiva." Stem Cells International 2015 (2015): 1–7. http://dx.doi.org/10.1155/2015/601731.

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The human ocular surface (front surface of the eye) is formed by two different types of epithelia: the corneal epithelium centrally and the conjunctival epithelium that surrounds this. These two epithelia are maintained by different stem cell populations (limbal stem cells for the corneal epithelium and the conjunctival epithelial stem cells). In this review, we provide an update on our understanding of these epithelia and their stem cells systems, including embryology, new markers, and controversy around the location of these stem cells. We also provide an update on the translation of this un

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Omaña-Molina, Maritza, Fernando Navarro-García, Arturo González-Robles, José de Jesús Serrano-Luna, Rafael Campos-Rodríguez, Adolfo Martínez-Palomo, Víctor Tsutsumi, and Mineko Shibayama. "Induction of Morphological and Electrophysiological Changes in Hamster Cornea after In Vitro Interaction with Trophozoites of Acanthamoeba spp." Infection and Immunity 72, no. 6 (June 2004): 3245–51. http://dx.doi.org/10.1128/iai.72.6.3245-3251.2004.

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ABSTRACT Acanthamoeba castellani and Acanthamoeba polyphaga are free-living amebae that cause keratitis and granulomatous encephalitis in humans. We have analyzed the early morphological and electrophysiological changes occurring during the in vitro interaction of cultured amebae with intact or physically damaged corneas obtained from hamsters. Both species of Acanthamoeba produced similar cytopathic changes, as seen by light microscopy and scanning electron microscopy. After adhesion to the epithelial surface, trophozoites formed clumps and migrated toward the cell borders, causing the separa

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Fu, Meng-Jun, Shan Duan, Hao-Run Zhang, Jing-Jing Zhao, Li Zeng, Rui Wang, and Xing-Tao Zhou. "Corneal histomorphology and electron microscopic observation of R124L mutated corneal dystrophy in a relapsed pedigree." International Journal of Ophthalmology 15, no. 9 (September 18, 2022): 1416–22. http://dx.doi.org/10.18240/ijo.2022.09.02.

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AIM: To investigate the histological characteristics and ultrastructure of recurrent Chinese R124L mutated corneal dystrophy after keratoplasty. METHODS: The subjects were enrolled from a Chinese family of corneal dystrophy with R124L heterozygous gene mutation and with a history of consanguineous marriage. Normal corneal samples were used as controls. RESULTS: In this family, 2 patients (3 eyes) underwent penetrating keratoplasty (PKP) and 2 patients (4 eyes) underwent lamellar keratoplasty (LKP). They had recurrence at 33.5±3.0 (range 30-36)mo after keratoplasty. Among them, 1 patient (1 eye

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Fukuoka, Hideki, Satoshi Kawasaki, Norihiko Yokoi, Kenta Yamasaki, and Shigeru Kinoshita. "Cytopathological Features of a Severe Type of Corneal Intraepithelial Neoplasia." Case Reports in Ophthalmology 7, no. 1 (May 11, 2016): 253–61. http://dx.doi.org/10.1159/000445937.

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Purpose: To report the cytopathological features of corneal intraepithelial neoplasia (CIN) through the investigation of cytokeratin expression pattern, keratinization, cell proliferation, apoptosis, and epithelial mesenchymal transition. Patient and Methods: Corneal tissue excised from a CIN patient was examined in this study. Cryosections of the excised CIN epithelial tissue were examined by immunostaining analysis using antibodies against cytokeratins, keratinization-related proteins, Ki-67, human telomerase reverse transcriptase (hTERT), and epithelial mesenchymal transition (EMT)-related

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Huhtala, Anne, Sami K. Nurmi, Hanna Tähti, Lotta Salminen, Päivi Alajuuma, Immo Rantala, Heikki Helin, and Hannu Uusitalo. "The Immunohistochemical Characterisation of an SV40-immortalised Human Corneal Epithelial Cell Line." Alternatives to Laboratory Animals 31, no. 4 (July 2003): 409–17. http://dx.doi.org/10.1177/026119290303100407.

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Alternatives to the Draize rabbit eye irritation test are currently being investigated. Because of morphological and biochemical differences between the rabbit and the human eye, continuous human cell lines have been proposed for use in ocular toxicology studies. Single cell-type monolayer cultures in culture medium have been used extensively in ocular toxicology. In the present study, an SV40-immortalised human corneal epithelial (HCE) cell line was characterised immunohistochemically, by using 13 different monoclonal antibodies to cytokeratins (CKs), ranging from CK3 to CK20. The results fro

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McKay, Tina B., Audrey E. K. Hutcheon, James D. Zieske, and Joseph B. Ciolino. "Extracellular Vesicles Secreted by Corneal Epithelial Cells Promote Myofibroblast Differentiation." Cells 9, no. 5 (April 26, 2020): 1080. http://dx.doi.org/10.3390/cells9051080.

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The corneal epithelium mediates the initial response to injury of the ocular surface and secretes a number of profibrotic factors that promote corneal scar development within the stroma. Previous studies have shown that corneal epithelial cells also secrete small extracellular vesicles (EVs) in response to corneal wounding. In this paper, we hypothesized that EVs released from corneal epithelial cells in vitro contain protein cargo that promotes myofibroblast differentiation, the key cell responsible for scar development. We focused on the interplay between corneal epithelial-derived EVs and t

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Theerakittayakorn, Kasem, Hong Thi Nguyen, Jidapa Musika, Hataiwan Kunkanjanawan, Sumeth Imsoonthornruksa, Sirilak Somredngan, Mariena Ketudat-Cairns, and Rangsun Parnpai. "Differentiation Induction of Human Stem Cells for Corneal Epithelial Regeneration." International Journal of Molecular Sciences 21, no. 21 (October 22, 2020): 7834. http://dx.doi.org/10.3390/ijms21217834.

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Deficiency of corneal epithelium causes vision impairment or blindness in severe cases. Transplantation of corneal epithelial cells is an effective treatment but the availability of the tissue source for those cells is inadequate. Stem cells can be induced to differentiate to corneal epithelial cells and used in the treatment. Multipotent stem cells (mesenchymal stem cells) and pluripotent stem cells (embryonic stem cells and induced pluripotent stem cells) are promising cells to address the problem. Various protocols have been developed to induce differentiation of the stem cells into corneal

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Sun, Tung-Tien. "Altered phenotype of cultured urothelial and other stratified epithelial cells: implications for wound healing." American Journal of Physiology-Renal Physiology 291, no. 1 (July 2006): F9—F21. http://dx.doi.org/10.1152/ajprenal.00035.2006.

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The differentiation of cultured stratified epithelial cells can deviate significantly from that of normal epithelium, leading to suggestions that cultured cells undergo abnormal differentiation, or a truncated differentiation. Thus cultured epidermal and corneal epithelial cells stop synthesizing their tissue-specific keratin pair K1/K10 and K3/K12, respectively. The replacement of these keratins in the suprabasal compartment by K6/K16 keratins that are made by all stratified squamous epithelia during hyperplasia rules out a truncated differentiation. Importantly, the keratin pattern of in viv

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Milyudin, E. S., and D. A. Drozdetskaya. "MEOHANisMs oF HEALiNG oF OoRNEAL DEFEOTs wiTH THE USE OF SiLiOA DESiCOATiON AMNiOTiO MEMBRANE." Aspirantskiy Vestnik Povolzhiya 19, no. 1-2 (March 15, 2019): 80–84. http://dx.doi.org/10.17816/2072-2354.2019.19.1.80-84.

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The purpose of this work is to study the mechanism of healing of corneal epithelium defect by using silica desiccation amniotic membrane at the cytomorphological level. 7 patients of Samara Regional Clinical Ophtalmologic Hospital named after T.I. Eroshevsky formed the main group of the perforemd study. They were diagnosed with recurrent trophic ulcers of the epithelium and corneal stroma. Their corneal defects were covered with the silica desiccation amniotic membrane. A control group included 5 patients with the same diagnosis. They were observed and treated without amniotic membrane applica

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Oliva, Joan, Fawzia Bardag-Gorce, and Yutaka Niihara. "Clinical Trials of Limbal Stem Cell Deficiency Treated with Oral Mucosal Epithelial Cells." International Journal of Molecular Sciences 21, no. 2 (January 9, 2020): 411. http://dx.doi.org/10.3390/ijms21020411.

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The corneal surface is an essential organ necessary for vision, and its clarity must be maintained. The corneal epithelium is renewed by limbal stem cells, located in the limbus and in palisades of Vogt. Palisades of Vogt maintain the clearness of the corneal epithelium by blocking the growth of conjunctival epithelium and the invasion of blood vessels over the cornea. The limbal region can be damaged by chemical burns, physical damage (e.g., by contact lenses), congenital disease, chronic inflammation, or limbal surgeries. The degree of limbus damage is associated with the degree of limbal st

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Cai, Cindy X., David E. Birk, and Thomas F. Linsenmayer. "Nuclear Ferritin Protects DNA From UV Damage in Corneal Epithelial Cells." Molecular Biology of the Cell 9, no. 5 (May 1998): 1037–51. http://dx.doi.org/10.1091/mbc.9.5.1037.

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Previously, we identified the heavy chain of ferritin as a developmentally regulated nuclear protein of embryonic chicken corneal epithelial cells. The nuclear ferritin is assembled into a supramolecular form indistinguishable from the cytoplasmic form of ferritin found in other cell types and thus most likely has iron-sequestering capabilities. Free iron, via the Fenton reaction, is known to exacerbate UV-induced and other oxidative damage to cellular components, including DNA. Since corneal epithelial cells are constantly exposed to UV light, we hypothesized that the nuclear ferritin might p

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Shen, Yun-Zhi, Mi Xu, and Song Sun. "In Vivo Confocal Microscopy Observation of Cell and Nerve Density in Different Corneal Regions with Monocular Pterygium." Journal of Ophthalmology 2020 (March 23, 2020): 1–7. http://dx.doi.org/10.1155/2020/6506134.

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Purpose. To investigate the effects of pterygium on corneal cell and nerve density in patients with unilateral pterygium using in vivo laser scanning confocal microscopy (LSCM). Methods. In this cross-sectional study, 24 patients with unilateral pterygium who were treated in the Department of Ophthalmology of the Second People’s Hospital of Wuxi City from April 2018 to July 2018 were analyzed. Each eye with pterygium and its fellow eye were imaged by LSCM. The density of basal corneal epithelial cells, anterior stromal cells, posterior stromal cells, dendritic cells, and endothelial cells in p

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Cejka, Cestmir, Vladimir Holan, Peter Trosan, Alena Zajicova, Eliska Javorkova, and Jitka Cejkova. "The Favorable Effect of Mesenchymal Stem Cell Treatment on the Antioxidant Protective Mechanism in the Corneal Epithelium and Renewal of Corneal Optical Properties Changed after Alkali Burns." Oxidative Medicine and Cellular Longevity 2016 (2016): 1–12. http://dx.doi.org/10.1155/2016/5843809.

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The aim of this study was to examine whether mesenchymal stem cells (MSCs) and/or corneal limbal epithelial stem cells (LSCs) influence restoration of an antioxidant protective mechanism in the corneal epithelium and renewal of corneal optical properties changed after alkali burns. The injured rabbit corneas (with 0.25 N NaOH) were untreated or treated with nanofiber scaffolds free of stem cells, with nanofiber scaffolds seeded with bone marrow MSCs (BM-MSCs), with adipose tissue MSCs (Ad-MSCs), or with LSCs. On day 15 following the injury, after BM-MSCs or LSCs nanofiber treatment (less after

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Borzenok, S. A., B. E. Malyugin, M. Yu Gerasimov, and D. S. Ostrovsky. "Cultivated autologous oral mucosal epithelial transplantation." Russian Journal of Transplantology and Artificial Organs 23, no. 1 (April 10, 2021): 171–77. http://dx.doi.org/10.15825/1995-1191-2021-1-171-177.

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According to the World Health Organization, corneal blindness is the fourth most common cause of blindness and visual impairment worldwide. In Russia, up to 18% of blindness is caused by corneal damage. Limbal stem cell deficiency (LSCD) is one of the causes of corneal blindness and visual impairment due to anterior epithelial replacement with fibrovascular pannus. Bilateral LSCD may develop in patients with aniridia, Steven-Jones syndrome, and severe corneal burns of both eyes, leading to severe decrease in visual acuity in both eyes and, as a consequence, physical disability associated with

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Jester, J. V., T. Moller-Pedersen, J. Huang, C. M. Sax, W. T. Kays, H. D. Cavangh, W. M. Petroll, and J. Piatigorsky. "The cellular basis of corneal transparency: evidence for ‘corneal crystallins’." Journal of Cell Science 112, no. 5 (March 1, 1999): 613–22. http://dx.doi.org/10.1242/jcs.112.5.613.

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In vivo corneal light scattering measurements using a novel confocal microscope demonstrated greatly increased backscatter from corneal stromal fibrocytes (keratocytes) in opaque compared to transparent corneal tissue in both humans and rabbits. Additionally, two water-soluble proteins, transketolase (TKT) and aldehyde dehydrogenase class 1 (ALDH1), isolated from rabbit keratocytes showed unexpectedly abundant expression (approximately 30% of the soluble protein) in transparent corneas and markedly reduced levels in opaque scleral fibroblasts or keratocytes from hazy, freeze injured regions of

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Soleimani, Mohammad, Kasra Cheraqpour, Raghuram Koganti, Seyed Mahbod Baharnoori, and Ali R. Djalilian. "Concise Review: Bioengineering of Limbal Stem Cell Niche." Bioengineering 10, no. 1 (January 12, 2023): 111. http://dx.doi.org/10.3390/bioengineering10010111.

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The corneal epithelium is composed of nonkeratinized stratified squamous cells and has a significant turnover rate. Limbal integrity is vital to maintain the clarity and avascularity of the cornea as well as regeneration of the corneal epithelium. Limbal epithelial stem cells (LESCs) are located in the basal epithelial layer of the limbus and preserve this homeostasis. Proper functioning of LESCs is dependent on a specific microenvironment, known as the limbal stem cell niche (LSCN). This structure is made up of various cells, an extracellular matrix (ECM), and signaling molecules. Different e

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Sun, Yan, Amy G. Hise, Carolyn M. Kalsow, and Eric Pearlman. "Staphylococcus aureus-Induced Corneal Inflammation Is Dependent on Toll-Like Receptor 2 and Myeloid Differentiation Factor 88." Infection and Immunity 74, no. 9 (September 2006): 5325–32. http://dx.doi.org/10.1128/iai.00645-06.

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ABSTRACT Toll-like receptors (TLRs) expressed by the corneal epithelium represent a first line of host defense to microbial keratitis. The current study examined the role of TLR2, TLR4, and TLR9 and the common adaptor molecule myeloid differentiation factor 88 (MyD88) in a Staphylococcus aureus model of corneal inflammation. The corneal epithelia of C57BL/6, TLR2−/−, TLR4−/−, TLR9−/−, and MyD88−/− mice were abraded using a trephine and epithelial brush and were exposed to heat- or UV-inactivated S. aureus clinical strain 8325-4 and other clinical isolates. Corneal thickness and haze were measu

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Das, Prosun, Jacintha Archana Pereira, Malay Chaklader, Aditya Law, Ketaki Bagchi, Gautam Bhaduri, Samaresh Chaudhuri, and Sujata Law. "Phenotypic alteration of limbal niche–associated limbal epithelial stem cell deficiency by ultraviolet-B exposure–induced phototoxicity in mice." Biochemistry and Cell Biology 91, no. 3 (June 2013): 165–75. http://dx.doi.org/10.1139/bcb-2012-0082.

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Good vision requires a healthy cornea, and a healthy cornea needs healthy stem cells. Limbal epithelial stem cells (LESCs) are a traditional source of corneal epithelial cells and are recruited for the continuous production of epithelium without seizing throughout an animal's life, which maintains corneal transparency. Like the maintenance of other adult somatic stem cells, the maintenance of LESCs depends on the specific microenvironmental niche in which they reside. The purpose of this study was to determine the microenvironmental damage associated with LESCs fate due to ultraviolet (UV)-B e

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Le-Bel, Gaëtan, Sergio Cortez Ghio, Louis-Philippe Guérin, Francis Bisson, Lucie Germain, and Sylvain L. Guérin. "Irradiated Human Fibroblasts as a Substitute Feeder Layer to Irradiated Mouse 3T3 for the Culture of Human Corneal Epithelial Cells: Impact on the Stability of the Transcription Factors Sp1 and NFI." International Journal of Molecular Sciences 20, no. 24 (December 13, 2019): 6296. http://dx.doi.org/10.3390/ijms20246296.

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Because of the worldwide shortage of graftable corneas, alternatives to restore visual impairments, such as the production of a functional human cornea by tissue engineering, have emerged. Self-renewal of the corneal epithelium through the maintenance of a sub-population of corneal stem cells is required to maintain the functionality of such a reconstructed cornea. We previously reported an association between stem cell differentiation and the level to which they express the transcription factors Sp1 and NFI. In this study, we investigated the impact of replacing irradiated 3T3 (i3T3) murine f

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Alcalde, Ignacio, Cristina Sánchez-Fernández, Susana Del Olmo-Aguado, Carla Martín, Céline Olmiere, Enol Artime, Luis M. Quirós, and Jesús Merayo-Lloves. "Synthetic Heparan Sulfate Mimetic Polymer Enhances Corneal Nerve Regeneration and Wound Healing after Experimental Laser Ablation Injury in Mice." Polymers 14, no. 22 (November 15, 2022): 4921. http://dx.doi.org/10.3390/polym14224921.

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(1) Background: Abnormal corneal wound healing compromises visual acuity and can lead to neuropathic pain. Conventional treatments usually fail to restore the injured corneal tissue. In this study, we evaluated the effectiveness of a synthetic heparan sulfate mimetic polymer (HSmP) in a mouse model of corneal wound healing. (2) Methods: A surgical laser ablation affecting the central cornea and subbasal nerve plexus of mice was used as a model of the wound-healing assay. Topical treatment with HSmP was contrasted to its vehicle and a negative control (BSS). Corneal repair was studied using imm

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Nili, Elham, Fiona J. Li, Rebecca A. Dawson, Cora Lau, Blair McEwan, Nigel L. Barnett, Steven Weier, Jennifer Walshe, Neil A. Richardson, and Damien G. Harkin. "The Impact of Limbal Mesenchymal Stromal Cells on Healing of Acute Ocular Surface Wounds Is Improved by Pre-cultivation and Implantation in the Presence of Limbal Epithelial Cells." Cell Transplantation 28, no. 9-10 (June 17, 2019): 1257–70. http://dx.doi.org/10.1177/0963689719858577.

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While limbal epithelial cells are used for treating ocular surface wounds, the therapeutic potential of mesenchymal cells cultivated from the limbal stroma (LMSC) is less clear. We have therefore examined the effects of LMSC when applied to acute ocular surface wounds. LMSC derived from male rabbits (RLMSC) were applied to the ocular surface of female rabbits immediately following removal of the corneal and limbal epithelium. Human amniotic membrane (HAM) was used as the vehicle for implanting the RLMSC. The effects of RLMSC were examined when applied alone ( n = 3) and in conjunction with a s

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