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Artículos de revistas sobre el tema "Coumarine"

Autor: Grafiati

Publicado: 4 de junio de 2021

Última modificación: 8 de febrero de 2022

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1

Hafiz, I. S. Abdel, A. M. Hussein y V. F. F. Mahmoud. "Nitriles in Heterocyclic Organic Synthesis: Synthesis of Pyrano[2,3-h]coumarines, Pyrano[3,2-c]coumarines, and their Derivatives". Zeitschrift für Naturforschung B 54, n.º 12 (1 de diciembre de 1999): 1568–72. http://dx.doi.org/10.1515/znb-1999-1215.

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Several new 4H-pyrano[2,3-h]coumarines 5a-e were prepared by the reaction of 7-hydroxycoumarine with cinnamonitriles 1. Also, the reaction of 7-hydroxycoumarine with a mixture of aliphatic aldehydes and malononitrile afforded compounds 5f,g. Similarly, 4-hydroxycoumarine was reacted with the same reagents to give compounds 9a-g. The reaction of 9 g with different nucleophilic reagents afforded the pyrimido[4′,5′:6,5]pyrano[3,2-c]coumarin-4-one derivatives 10-12, 4-methyl-2-(ethoxymethylenamino)4H-pyrano[3,2-c]coumarine-3-carbonitrile (13) and pyrazolo[3′,4′;6,5]pyrano[3,2-c]coumarine (14) respectively.

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2

Mulia, Melindra. "ISOLASI KUMARIN DARI KULIT BUAH LIMAU SUNDAI (Citrus nobilis Lour)". EKSAKTA: Berkala Ilmiah Bidang MIPA 18, n.º 02 (30 de noviembre de 2017): 137–45. http://dx.doi.org/10.24036/eksakta/vol18-iss02/70.

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Coumarin has been isolated and characteritated from rind of Citrus nobilis Lour by maseration methode with methanol. After fractionation by n-hexane and ethyl acetate, collected the phase ethyl acetate which positive of coumarin. From ethyl acetate extract coumarin have been isolated by column chromatography. The isolation results was obtain 2,159 g of pure white needle-shape crystalline with the melting point of 126,2-127,60C. Structure of the isolated coumarine was elucidated by spectroscopic methodes, UV-Vis,13C-NMR, 1H-NMR, 2D-NMR (DEPT/HSQC, COSY, NOESY, HMBC) and IR spectra. Based on the spectra data the isolated coumarine is marmin.

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3

Mohtat, Bita, Semiramis Nahavandian, Maryam Razaghi, Saeedeh Farsijani y Hoorieh Djahaniani. "Triphenylphosphine Mediated Synthesis of Functionalized Benzo-Fused Coumarins from Some OH Acids and Dialkyl Acetylene Dicarboxylate". Journal of Chemistry 2013 (2013): 1–5. http://dx.doi.org/10.1155/2013/289636.

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Benzo-fused coumarins are prepared from 4-quinolinol by treatment with PPh3and dialkyl acetylenedicarboxylate. Angular coumarins are prepared from 3-isoquinolinol and 7-hydroxyl coumarine with PPh3and dialkyl acetylenedicarboxylate.

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4

Gurlui, Silviu, Ion Sandu, Nicanor Cimpoesu, Valentin Pohoata, Ioan Gabriel Sandu y Mitachi Strat. "Nanoaggregates and Selforganization Phenomena in Polyurethane Coumarine Film". Materiale Plastice 54, n.º 3 (30 de septiembre de 2017): 589–92. http://dx.doi.org/10.37358/mp.17.3.4903.

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The spectroscopic and photochemical properties of polyurethane coumarine (PUC) in solid state were investigated at room temperature under once-photon excitation. One photon induced photocycloaddition of PUC was investigated and the AFM and spectroscopic FTIR analysis confirmed dimer formation. The AFM analysis shows that the fotodimerization process occurs at the surface of polymer films. The polyurethane coumarine film on CaF2 unirradiated and irradiated underline both the fotodimerization of the polymer films as well as the photoclevage of the polyurethane coumarin.

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5

González-Pérez, M., S. Y. Ooi, S. Martins, João P. Prates Ramalho, A. Pereira y A. T. Caldeira. "Gaining insight into the photophysical properties of a coumarin STP ester with potential for bioconjugation". New Journal of Chemistry 42, n.º 20 (2018): 16635–45. http://dx.doi.org/10.1039/c8nj03548b.

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The photophysical properties of a coumarin 392 4-sulfotetrafluorophenyl ester, C392STP (sodium (E/Z)-4-(4-(2-(6,7-dimethoxycoumarin-3-yl)vinyl)-benzoyl)-2,3,5,6-tetrafluoro-benzenesulfonate), an amine reactive coumarine with potential for bioconjungation, have been studied in different solvents.

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6

Rabtti, El, Maja Natic, Dusanka Milojkovic-Opsenica, Jelena Trifkovic, Tomislav Tosti, Ivan Vuckovic, Vlatka Vajs y Zivoslav Tesic. "Quantitative structure-toxicity relationship study of some natural and synthetic coumarins using retention parameters". Journal of the Serbian Chemical Society 77, n.º 10 (2012): 1443–56. http://dx.doi.org/10.2298/jsc120716091r.

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Four lipophilicity descriptors (RM0, b, C0, PC1) for twelve coumarine derivatives were determined by reversed-phase thin-layer chromatography in order to analyze which descriptor best describes the lipophilicity of coumarines investigated. Moreover, possible chemical toxicity of coumarins, expressed as the probability of a compound to cause organ-specific health effects, was calculated using ACD/Tox Suite program. The quantitative relationships between toxicity and molecular descriptors, including experimentally determined lipophilicity descriptors obtained in current study, were investigated using partial least square regression. The best models were obtained for kidney and liver health effects. Quantitative structure-toxicity relationship models revealed the importance of electric polarization descriptors, size descriptors and lipophilicity descriptors. Obtained models were used for the selection of the structural features of the compounds that are significantly affecting their absorption, distribution, metabolism, excretion, and toxicity.

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7

Ibrahim, Sanusi, Muhamad Iqbal y Bustanul Arifin. "ISOLASI KUMARIN DARI BIJI PINANG (Areca catechu L.)". Jurnal Riset Kimia 1, n.º 1 (11 de febrero de 2015): 50. http://dx.doi.org/10.25077/jrk.v1i1.71.

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ABSTRACT Coumarin has been isolated from seed of Areca catechu L. an ethyl acetate fraction which needle crystal products at 184 –185°C. Based on thin layer chromatography analysis using n-hexane : acetone (4 : 6) as eluent got Rf 0.6. From elemental analysis, mass spectra, ultraviolet spectra, infra red spectra, nuclear magnetic resonance spectra ( H and C NMR) ,concluded this compound was 7-hidroksi-4-metil coumarine. Keywords : Areca catechu, 7-hidroksi-4-metil kumarin.

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8

Shahi, Akbar Massoumi, Mohammad Nikpassand y Leila Zare Fekri. "Acidic Ionic Liquid-catalyzed Synthesis of Pyrano[4,3-b]pyran-5(4H)-ones using 4,4,4-trifluoro-1-phenylbutane-1,3-dione as a Building Block". Current Organic Synthesis 17, n.º 8 (28 de octubre de 2020): 648–53. http://dx.doi.org/10.2174/1570179417666200520111536.

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Aims: synthesis of pyrano[c-2,3]chromens with Ionic Liquid catalyst with simple method. Background: Synthesis of pyrano[c]coumarins has a special place in the structure due to two bioactive compounds in its structure and attracts a great deal of attention in this research work, it has been attempted to attach chromatically valuable skeletons to them and synthesize the pyrano [c] coumarines, which can potentially have high biological properties. For this purpose, electrophilic β-ketoester ringing in the presence of ionic liquid catalysts was used. While optimizing the catalyst recovery, it is possible to synthesize several coumarine pyrano[ c]derivatives with high yield. Objective: This paper describes an efficient procedure for the multi-component reaction of aromatic aldehydes, 4,4,4-Trifluoro-1-phenyl-1,3-butanedione and 4-hydroxycoumarinwhich catalyzed by Ioniq liquid (OlmDSA), at room temperature. This catalyst was synthesized with new simple procedure. This protocol has advantages of simplicity, mild condition and high yield. Materials and Methods: After formation of a new stain corresponding to the alkene intermediate, 4-hydroxy coumarin (1 mM) was added. The reaction was progressed by thin layer chromatography in a 1: 2 ratio solvent containing ethyl acetate and hexane. The reaction mixture was then stirred for one hour. After the reaction was complete, the catalyst was first removed by washing. Ethanol was then added to the reaction residue and washed and finally filtered. The residual solid on the filter paper after drying was considered as the product and was taken to confirm. its structure, melting point and spectra. The following is a general overview of the reaction. Results and Discussion: In addition to the advantages mentioned for this tri-component reaction, the conservation of the coumarin ring is very important in this research design because it is formed in many of the reported open reactions and phenolic ring. Conclusion: The benefits of this work include simple reaction steps, review of reaction progress by TLC chromatography, simple separation of the catalyst by washing and reuse for three times without any reduction in yield and high reaction yield.

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9

Horner, Leopold y Christoph Franz. "Studien zum Vorgang der Wasserstoffübertragung, 76 [1]. Der anomale Verlauf der Elektroreduktion von Cumarin mit Lithium als Leitsalzkation: Versuche zur Reaktionslenkung durch Mediatoren / Studies on the Occurrence of Hydrogen Transfer, 76 [1] The Anomal Course of the Electroreduction of Coumarine with Supporting Electrolyts Containing Li+: Experiments to Influence the Reaction by Mediators". Zeitschrift für Naturforschung B 40, n.º 6 (1 de junio de 1985): 822–25. http://dx.doi.org/10.1515/znb-1985-0621.

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Abstract In contradiction to the experience the hydrodimer is formed as the main product in the electroreduction of coumarine using lithium compounds as a supporting electrolyt. It is assumed that the lithium ions are coordinated internally with the radicalanion A resp. B derived from coumarine. In this way the hydrodimerization is favoured. From 18 different compounds added as possible mediators to the catholyt only pyridine influences moderately the ratio: hydrodimerizationproduct/dihydroproduct.

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10

Al-Majedy, Yasameen K., Hiba H. Ibraheem, Liblab Sami Jassim y Ahmed A. Al-Amiery. "Antioxidant Activity of Coumarine Compounds". Al-Nahrain Journal of Science 22, n.º 1 (1 de marzo de 2019): 1–8. http://dx.doi.org/10.22401/anjs.22.1.01.

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11

Metelitsa, A. V., M. I. Knyazhansky, V. V. Ivanitsky, O. G. Nikolaeva, V. A. Palchkov, A. P. Panina, N. E. Shelepin y V. I. Minkin. "Photochromic Spiropyrans of Coumarine Series". Molecular Crystals and Liquid Crystals Science and Technology. Section A. Molecular Crystals and Liquid Crystals 246, n.º 1 (mayo de 1994): 37–40. http://dx.doi.org/10.1080/10587259408037784.

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12

Muttaqin, Fauzan Zein, Taufik Muhammad Fakih y Hubbi Nashrullah Muhammad. "MOLECULAR DOCKING, MOLECULAR DYNAMICS, AND IN SILICO TOXICITY PREDICTION STUDIES OF COUMARIN, N-OXALYLGLYCINE, ORGANOSELENIUM, ORGANOSULFUR, AND PYRIDINE DERIVATIVES AS HISTONE LYSINE DEMETHYLASE INHIBITORS". Asian Journal of Pharmaceutical and Clinical Research 10, n.º 12 (1 de diciembre de 2017): 212. http://dx.doi.org/10.22159/ajpcr.2017.v10i12.19348.

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Objective: Prostate cancer is the second most common cancer in men. One of the efforts in the treatment of prostate cancer is by inhibiting histone lysine demethylase. Derivative compounds of coumarine, N-oxalylglycine, organoselenium, organosulfur, and pyridine have been reported to be active against two types of histone lysine demethylase (KDM) enzymes, KDM4E and KDM5B. This study aims to study the interactions of these derivatives with KDM.Methods: In this study, we performed computational studies, including molecular docking and molecular dynamics (MDs) simulations, and toxicity prediction, to assess the compounds’ activities toward three other KDM enzymes, KDM1A, KDM4A, and KDM4C.Results: Molecular docking simulations showed that a derivative compound of N-oxalylglycine, (R)-3-(4-[benzyloxy]phenyl)-2-(carboxyformamido) propanoic acid, and a derivative compound of pyridine, 3-(4-methoxybenzylamino)pyridine-2,4-dicarboxylic acid, has the highest affinity toward KDM. These results were confirmed in MDs studies which showed strong interactions at the active site of the five receptors. Toxicity prediction results show that the derivative compounds of coumarine, N-oxalylglycine, organoselenium, organosulfur, and pyridine are classified in category (high class), which suggests that the safety is not guaranteed, but is likely, not carcinogenic and nongenotoxic.Conclusion: Several coumarin, N-oxalylglycine, organoselenium, organosulfur, and pyridine derivative compounds are predicted to be able to interact strongly with KDM. The results in this study are useful for further studies in the development of novel anticancer drugs that target KDM.

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13

Holubekova, Alzbeta, Pavel Mach y Jan Urban. "Spectral properties of coumarin derivatives in various environments". Open Chemistry 11, n.º 4 (1 de abril de 2013): 492–501. http://dx.doi.org/10.2478/s11532-012-0185-0.

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AbstractThe structural and spectral properties of coumarin derivatives in complex environments were investigated within the time-dependent density functional theory (TD DFT). Absorption spectra calculations were obtained at TD PBE0/6-31+G(d,p) level of theory for coumarin47 in the gas-phase and in various polar and non-polar organic solvents. The geometries of coumarins 6, 30, 47 and 522 in the gas phase and in inclusion complexes with the β-cyclodextrin (βCD) were determined by PM3 and DFT (HCTH/6-31G) calculations. Encapsulation of coumarin in βCD and associated changes in electronic structure produced either a red or blue shift in the absorption spectra of coumarins. A proposed cavity model for βCD-coumarin complex in water solution allowed identification of various contributions to the overall shift in the absorption spectra of coumarin upon complex formation in a solvent environment

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14

Cilibrizzi, Agostino, Marina Fedorova, Juliet Collins, Robin Leatherbarrow, Rudiger Woscholski y Ramon Vilar. "A tri-functional vanadium(iv) complex to detect cysteine oxidation". Dalton Transactions 46, n.º 21 (2017): 6994–7004. http://dx.doi.org/10.1039/c7dt00076f.

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15

Horner, L. y Ch Franz. "Studien zum Vorgang der Wasserstoffübertragung, 74 [1]. Elektroreduktive Hydrierungen an Raney-Nickel-Pulver als Kathode / Studies on the Occurrence of Hydrogen Transfer, 74 [1]. Electroreductive Hydrogenation Using Raney-Nickel-Powder as a Cathode". Zeitschrift für Naturforschung B 40, n.º 6 (1 de junio de 1985): 808–13. http://dx.doi.org/10.1515/znb-1985-0619.

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Abstract Cathodically pretreated Raney-nickel-powder with a potential of -900 to -1000 mV (vs SCE) shows a positive potential shift of 200 to 300 mV in the presence of a hydrogen acceptor (coumarine or 1-ethinylcyclohexanol (1)). Pyridine and quinoline do not have any strong influence on the potential but retard the hydrogenation of coumarine. Acetylene derivatives as 1-ethinylcyclohexanol are hydrogenated in two steps applying a potential down to -1050 mV. At -1150 mV the selectivity is lost. With Raney-nickel-powder pre-treated with pyridine or hydrogensulfide the two-step selectivity of the hydrogenation of 1 is preserved applying also a potential of -1200 mV.

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16

Ventura, Thatiana, Diego Silva, Elena Lassounskaia, Edmilson Maria, Michelle Muzitano y Rodrigo R. de Oliveira. "Coumarine Analogues with Antimycobacterial and Immunomodulatory Activity". Current Bioactive Compounds 11, n.º 2 (20 de agosto de 2015): 109–15. http://dx.doi.org/10.2174/157340721102150820130149.

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17

El-Taweel, Fathy Mohamed Abdel Aziz, Salah Zaki Ahmed Sowellim y Abdel Ghani Ali Elagamey. "Reactions with 2(1H)-Quinolinone and Coumarine Derivatives: New Routes to Polysubstituted 2(1H)-Quinolinone and Coumarine Derivatives". Bulletin of the Chemical Society of Japan 68, n.º 3 (marzo de 1995): 905–10. http://dx.doi.org/10.1246/bcsj.68.905.

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18

Sokolova, I. V., N. Yu Vasil'eva, Ya O. Vylegzhanina y G. V. Maier. "Electronic structure, spectra, and nature of electronically excited states of the bifluorophores stilbene-CH2-coumarine and phenyl-CH2-coumarine". Russian Physics Journal 36, n.º 9 (septiembre de 1993): 882–86. http://dx.doi.org/10.1007/bf00559002.

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19

Chattopadhyay, Kalicharan, Erik Fenster, Alexander J. Grenning y Jon A. Tunge. "Palladium-catalyzed substitution of (coumarinyl)methyl acetates with C-, N-, and S-nucleophiles". Beilstein Journal of Organic Chemistry 8 (27 de julio de 2012): 1200–1207. http://dx.doi.org/10.3762/bjoc.8.133.

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The palladium-catalyzed nucleophilic substitution of (coumarinyl)methyl acetates is described. The reaction proceeds though a palladium π-benzyl-like complex and allows for many different types of C-, N-, and S-nucleophiles to be regioselectively added to the biologically active coumarin motif. This new method was utilized to prepare a 128-membered library of aminated coumarins for biological screening.

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20

Dimić, Dušan S., Zoran S. Marković, Luciano Saso, Edina H. Avdović, Jelena R. Đorović, Isidora P. Petrović, Danijela D. Stanisavljević et al. "Synthesis and Characterization of 3-(1-((3,4-Dihydroxyphenethyl)amino)ethylidene)-chroman-2,4-dione as a Potential Antitumor Agent". Oxidative Medicine and Cellular Longevity 2019 (13 de febrero de 2019): 1–12. http://dx.doi.org/10.1155/2019/2069250.

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The newly synthesized coumarin derivative with dopamine, 3-(1-((3,4-dihydroxyphenethyl)amino)ethylidene)-chroman-2,4-dione, was completely structurally characterized by X-ray crystallography. It was shown that several types of hydrogen bonds are present, which additionally stabilize the structure. The compound was tested in vitro against different cell lines, healthy human keratinocyte HaCaT, cervical squamous cell carcinoma SiHa, breast carcinoma MCF7, and hepatocellular carcinoma HepG2. Compared to control, the new derivate showed a stronger effect on both healthy and carcinoma cell lines, with the most prominent effect on the breast carcinoma MCF7 cell line. The molecular docking study, obtained for ten different conformations of the new compound, showed its inhibitory nature against CDKS protein. Lower inhibition constant, relative to one of 4-OH-coumarine, proved stronger and more numerous interactions with CDKS protein. These interactions were carefully examined for both parent molecule and derivative and explained from a structural point of view.

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21

Journal, Baghdad Science. "Study the Spectral Properties of Coumarine -47 Dissolved in Chloroform". Baghdad Science Journal 11, n.º 2 (1 de junio de 2014): 635–40. http://dx.doi.org/10.21123/bsj.11.2.635-640.

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The spectral propetties (absorption and fluorescence) of Coumarine-47 laser dye have been studied. This type of laser dye belong the Coumarine family and it has dissolved in chloroform at different concentrations (1x10-5, 5x10-5, and 1x10-4 M) at room temperature. The achieved results have been pointed out to increase in the absorption and fluorescence as the concentration increased which are agreements with Beer – Lambert law. These have been also showed an expansion in the spectral range of absorption and fluorescence with a noticed shift in the direction of longer wavelength (Red-shift) with increasing concentration. The quantum efficiency of the dissolved C47 in chloroform has been computed by using the brevious concentrations and their results are as follows (69%, 63%, and 45%) respectively. The radiative and fluorescence lifetime have been also computed as given (6.47ns, 4.67ns, and 2.06ns) and (4,07ns, 3.22ns, and 1.47ns) respectively.

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22

Gh-Bedewy, W., O. Salih y A. Ahmad. "Synthesis of New Pyrazolines Derivatives from Coumarine Compounds". JOURNAL OF EDUCATION AND SCIENCE 24, n.º 3 (30 de noviembre de 1999): 34–40. http://dx.doi.org/10.33899/edusj.1999.58792.

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23

Govori. "Antimicrobial Properties of Newly Synthesized Derivatives of Coumarine". American Journal of Biochemistry and Biotechnology 6, n.º 4 (1 de abril de 2010): 275–78. http://dx.doi.org/10.3844/ajbbsp.2010.275.278.

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24

EL-TAWEEL, F. M. A. A., S. Z. A. SOWELLIM y A. G. A. ELAGAMEY. "ChemInform Abstract: Reactions with 2(1H)-Quinolinone and Coumarine Derivatives: New Routes to Polysubstituted 2(1H)-Quinolinone and Coumarine Derivatives." ChemInform 26, n.º 31 (17 de agosto de 2010): no. http://dx.doi.org/10.1002/chin.199531153.

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25

Jablonský, Michal, Helena Ramajová, Aleš Ház, Alexandra Sládková, Andrea Škulcová y Katarína Čížová. "Comparison of Different Methods for Extraction from Lavender: Yield and Chemical Composition". Key Engineering Materials 688 (abril de 2016): 31–37. http://dx.doi.org/10.4028/www.scientific.net/kem.688.31.

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A comparative study of accelerated solvent extraction (ASE) with two conventional volatile isolation methods including traditional steam distillation and Soxhlet extraction was performed on lavender. ASE was carried out by butanol (polar protic solvent) or dichloromethane (nonpolar solvent) and the temperature was 120°C. Separation and identification of the components was carried out by GC/MS. The main components of the analysed samples were Linalool (14.79%), α-Terpineol (4.42%), Linalool oxide (furanoid) (2.92%), cis-linalyl oxide (2.8%), α-Bisabolol (1.86%) and Octacosane (1.56%) for steam distillation; for ASE (dichlormethane): β-Terpineol (2.06%), Linalyl anthranilate (1.82%), Largeracetal (1.82%), Eucalyptol (1.74%), Linalool (1.73%), Coumarine (1.28%) and Caryophylene oxide (1.08%); for ASE (butanol): Lageracetal (8.29%), Octacosane (1.75%), Eucalyptol (1.05%) and Caryophyllene oxide (1.02%) and for Soxhlet (butanol): Largeracetal (11.42%), Linalool (3.36%), Coumarine (0.83%) and Eucalyptol (0.74%). The study has shown that ASE is a fast and environmentally sustainable technique, using butanol and dichloromethane as solvent for the extraction of extractive compounds from lavender.

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Sravani G, Linga Naik A, Kranthi A y Priyanka G. "Preparation and Analysis of Coumarin Compound for New Application". International Research Journal of Pharmaceutical and Applied Sciences 8, n.º 4 (25 de junio de 2020): 33–35. http://dx.doi.org/10.26452/irjpas.v8i4.1321.

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Numerous normally occurring substances usually applied in famous drugs the world over, incorporate the coumarin moiety. Coumarin speaks to a unique platform for restorative scientists, in light of its unconventional physicochemical highlights, and the adaptable and easy engineered change right into a huge assortment of functionalized coumarone. As an outcome, countless coumarin subordinates were dependent, incorporated, and tried to cope with numerous pharmacological focuses in a particular way, e.G., specific chemical inhibitors, and all of the extra as of past due, numerous chose targets (multitarget ligands) associated with multifactorial illnesses, as an instance, Parkinson's and Alzheimer's infections. In this survey, a definition of today's manufactured paths prompting mono-and polyfunctionalized coumarins might be introduced, alongside the precept natural pathways in their biosynthesis and metabolic adjustments. The numerous current and overdue audits in the discipline provoked us to type-specific terrific alternatives. Subsequently, the survey is targeted around following up on chosen focuses on neurodegenerative illnesses.

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Prahadeesh, N., Maheswaran Sithambaresan y Umaramani Mathiventhan. "A Study on Hydrogen Peroxide Scavenging Activity and Ferric Reducing Ability of Simple Coumarins". Emerging Science Journal 2, n.º 6 (13 de diciembre de 2018): 417. http://dx.doi.org/10.28991/esj-2018-01161.

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Coumarin compounds are δ-lactones where α-pyrone ring is fused with benzene ring. Coumarins are widely distributed in the plant kingdom as well as they are very important in synthetic organic chemistry. Coumarins have great interest because of their abundance in nature and diverse pharmacological activities including antibacterial, antiviral, antipyretic, and anticoagulant, antioxidant, anti-inflammatory and anticancer. This study focused on synthesizing different simple Coumarins and studying their antioxidant activity. Four simple Coumarins (Coumarin (C1), 4-hydroxy coumarin (C2), 7-hydroxy coumarin (C3) and 7-hydoxy-4-methyl coumarin (C4)) were synthesized by using standard methods and were characterized by using UV, IR, 1H and 13C NMR spectra. Antioxidant activity of the simple Coumarins was studied by using standard FRAP assay and Hydrogen peroxide assay and expressed as FRAP value (mmol Fe2+/g) and IC50 value (mg/dm-3) respectively. Ascorbic acid was used as standard. All synthesized simple Coumarins showed both antioxidant activities. Hydroxyl Coumarins (C2, C3 and C4) showed higher activities in both cases than C1. Among the hydroxyl Coumarins C3 showed highest hydrogen peroxide scavenging activity and Ferric reducing capacity too. Antioxidant power of the tested simple Coumarins in decreasing order was C3, C2, C4 and C1 in both cases. But the hydrogen peroxide scavenging activity and Ferric reducing capacity of the all synthesized simple Coumarins were lower when compared to standard ascorbic acid.

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28

Channabasava y Govindappa Melappa. "Identification of Bioactive Coumarin(s) from Three Endophytic Fungal Species of Calophyllum tomentosum". Natural Products Journal 10, n.º 4 (21 de agosto de 2020): 502–12. http://dx.doi.org/10.2174/2210315509666190430145906.

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Background: Many biologically important bioactive compounds have been identified in Calophyllum tomentosum extract. Hence, we aimed to identify different endophytic fungal species from different parts of the plants and their bioactive compounds. Objective: The study includes identification and characterization of bioactive compounds in the extracts of endophytic fungal species of Calophyllum tomentosum. Methods: Different parts were used to assess the different endophytic fungi. Two different solvents were used: extracts and qualitative solvents. TLC and GC-MS were employed to identify the bioactive compounds. The bioactive compounds producing endophytes were identified by using18S rRNA. Results: In total, 13 different fungal species were identified from different parts of the Calophyllum tomentosum. The C. tomentosum leaf part showed seven different fungal endophytes from the barks (four) and stems (two). The methanol extract of Fusarium species (stem), Cladosporium species (bark) and hexane extract of Alternaria species (bark) showed a higher amount of coumarins in qualitative methods and TLC. Based on the above results, for further GC-MS and molecular identification studies, we selected three endophytes. In the GC-MS analysis, the methanol extract of Fusarium species (stem) showed psoralen, and furocoumarin (imperatonin or ammidin); Cladosporium species (bark) showed coumarin (2H-1-benzopyran-2-one), coumaric acid (3-benzofurancarboxylic acid), hynecromone (coumarin 4), 4-hydroxy-9-(3-methyl-2-butyl)furo(3,2-g)chloronen-7- one; and hexane extract of Alternaria species (bark) showed coumaric acid (3-benzofurancarboxylic acid). The three fungal endophytes were identified as Fusarium equiseti, Cladosporium uredinicola and Alternaria alternata from 18S rRNA analysis. Conclusions: Based on the above results, the three endophytic fungal species confirm the presence of coumarins and therefore, can be used for the production of coumarins instead of the plant.

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Jiang, Zhen-Ju, Hong-Shui Lv, Jian Zhu y Bao-Xiang Zhao. "New fluorescent chemosensor based on quinoline and coumarine for Cu2+". Synthetic Metals 162, n.º 23 (diciembre de 2012): 2112–16. http://dx.doi.org/10.1016/j.synthmet.2012.09.013.

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Delettré, J., M. E. Delaitre, P. Vigny y E. Bisagni. "Structure de la furo[3,2-g]coumarine-3-carboxylate d'éthyle". Acta Crystallographica Section C Crystal Structure Communications 42, n.º 12 (15 de diciembre de 1986): 1849–51. http://dx.doi.org/10.1107/s0108270186090303.

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31

M, Govindappa, Channabasava, Ritu Pawar, Chandrasekhar Srinivasa, Chandan Shivamallu y Manoj-Kumar Arthikala. "Endophytic Fungi Penicillium species BCt Phytochemicals Inhibit Replication of Enzymes of Human Immuno-deficiency Virus 1 in in vitro and in silico Studies". International Journal of Pharmaceutical Sciences and Nanotechnology 14, n.º 5 (1 de septiembre de 2021): 5624–33. http://dx.doi.org/10.37285/ijpsn.2021.14.5.6.

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The present investigation was aimed to know the coumarins in the methanol extract of endophytic fungi, Penicillium species BCt isolated from Calophyllum tomentosum bark tissues using qualitative and GC-MS analysis. The endophytic extract was evaluated for anti-HIV activity on three replicating enzymes in vitro and in silico. The methanol extract of Penicillium species confirmed the presence of coumarins in four qualitative methods and yielded four different types of coumarins in GC-MS. In GC-MS analysis, totally seven different phytochemicals were identified based on retention time and compared with available library data. The four coumarins are coumarin (2H-1-benzopyran-2-one), coumaric acid (3-benzofuran-carboxylic acid), hynecromone (coumarin 4), 4-hydroxy-9-(3-methyl-2-butyl) furo (3,2-g) chloronen-7-one) and other three are common phytochemicals. The HIV-1 RT (98) was strongly inhibited by the endophytic fungal extract compared to integrase (118) and protease (158) in vitro analysis. Highest inhibition of integrase was observed with coumarilic acid (-17.62) when attached to Glu-35, Asn-38, Ser-39 amino acids. The protease was inhibited strongly by hymecromone (-16.39) when attached to amino acids of Val-77, Glu-34, Pro-79, Gly-78. The inhibition of RT was observed with coumarilic acid by attaching to Ala-445, Arg-567, Asp-456, Glu-478, Ser-499, Asn-474 (-23.54) significantly. Based on above results, the endophytic fungal coumarins have the ability to inhibit the three replicating enzymes of HIV-1 significantly. The in-silico results are evidence for how coumarins inhibiting the HIV replicating proteins by binding at specific amino acids. The results will help to understand how and where phytochemicals bind to target proteins to inhibit their action and it may help to identification of drugs to treat HIV. To validate our results, the in vivo research is needed.

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Airoldi, Cristina, Francisco Cardona, Erika Sironi, Laura Colombo, Mario Salmona, Ilaria Cambianica, Francesca Ornaghi, Giulio Sancini, Francesco Nicotra y Barbara La Ferla. "Fluorescent amyloid β-peptide ligand derivatives as potential diagnostic tools for Alzheimer’s disease". Pure and Applied Chemistry 85, n.º 9 (1 de septiembre de 2013): 1813–23. http://dx.doi.org/10.1351/pac-con-12-11-07.

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Aβ-peptide ligands based on a cis-glycofused benzopyran structure have been fluorescently labeled using coumarine derivatives. Among the synthesized compounds, two conserved their binding ability to β-amyloid peptides, as shown by NMR experiments. Moreover, exploiting its fluorescent property, it was demonstrated that one of such compounds was able to cross an in vitro model of blood–brain barrier (BBB) and to stain Aβ‑deposits.

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33

M. Gomha, Sobhi y Hassan M. Abdel-aziz. "Synthesis and Antitumor Activity of 1,3,4-Thiadiazole Derivatives Bearing Coumarine Ring". HETEROCYCLES 91, n.º 3 (2015): 583. http://dx.doi.org/10.3987/com-14-13146.

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Capparelli, Elena, Marialessandra Contino, Maria G. Perrone, Francesco Berardi, Roberto Perrone, Marcello Leopoldo y Nicola A. Colabufo. "Functionalized Coumarine Fragment to Obtain Fluorescent and Selective P-Glycoprotein Ligands". Archiv der Pharmazie 349, n.º 3 (11 de enero de 2016): 161–67. http://dx.doi.org/10.1002/ardp.201500325.

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35

Muià, Carmelo, Emanuela Mazzon, Daniele Zito, Daniele Maiere, Domenico Britti, Concetta Crisafulli, Giacomo Oteri, Giancarlo Cordasco y Salvatore Cuzzocrea. "Cloricromene, a coumarine derivative, reduced the development of periodontitis in rats". Naunyn-Schmiedeberg's Archives of Pharmacology 373, n.º 1 (28 de marzo de 2006): 51–59. http://dx.doi.org/10.1007/s00210-006-0048-3.

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36

Squadrito, Francesco, Domenica Altavilla, Giuseppe M. Campo, Gioacchino Calapai, Mariapatrizia Ioculano, Basilia Zingarelli, Antonino Saitta, Marco Prosdocimi y Achille P. Caputi. "Cloricromene, a coumarine derivative, protects against lethal endotoxin shock in rats". European Journal of Pharmacology 210, n.º 2 (enero de 1992): 107–13. http://dx.doi.org/10.1016/0014-2999(92)90660-v.

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37

Endo, Tadashi, Nobuyuki Nakada, Tsugio Sato y Masahiko Shimada. "The fluorescence properties of coumarine dye intercalated in a swelling clay". Journal of Physics and Chemistry of Solids 50, n.º 2 (enero de 1989): 133–37. http://dx.doi.org/10.1016/0022-3697(89)90409-5.

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38

Stringlis, Ioannis A., Ronnie de Jonge y Corn� M. J. Pieterse. "The Age of Coumarins in Plant–Microbe Interactions". Plant and Cell Physiology 60, n.º 7 (10 de mayo de 2019): 1405–19. http://dx.doi.org/10.1093/pcp/pcz076.

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Abstract Coumarins are a family of plant-derived secondary metabolites that are produced via the phenylpropanoid pathway. In the past decade, coumarins have emerged as iron-mobilizing compounds that are secreted by plant roots and aid in iron uptake from iron-deprived soils. Members of the coumarin family are found in many plant species. Besides their role in iron uptake, coumarins have been extensively studied for their potential to fight infections in both plants and animals. Coumarin activities range from antimicrobial and antiviral to anticoagulant and anticancer. In recent years, studies in the model plant species tobacco and Arabidopsis have significantly increased our understanding of coumarin biosynthesis, accumulation, secretion, chemical modification and their modes of action against plant pathogens. Here, we review current knowledge on coumarins in different plant species. We focus on simple coumarins and provide an overview on their biosynthesis and role in environmental stress responses, with special attention for the recently discovered semiochemical role of coumarins in aboveground and belowground plant–microbe interactions and the assembly of the root microbiome.

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39

Bevans, Carville, Andreas Fregin, Christof Geisen, Clemens Müller-Reible, Matthias Watzka y Johannes Oldenburg. "Current pharmacogenetic developments in oral anticoagulation therapy: The influence of variant VKORC1 and CYP2C9 alleles". Thrombosis and Haemostasis 98, n.º 09 (2007): 570–78. http://dx.doi.org/10.1160/th07-07-0454.

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SummaryFor decades coumarins have been the most commonly prescribed drugs for therapy and prophylaxis of thromboembolic conditions. Despite the limitation of their narrow therapeutic dosage window, the broad variation of intra- and inter-individual drug requirement, and the relatively high incidence of bleeding complications,prescriptions for coumarins are increasing due to the aging populations in industrialised countries.The identification of the molecular target of coumarins,VKORC1, has greatly improved the understanding of coumarin treatment and illuminated new perspectives for a safer and more individualized oral anticoagulation therapy. Mutations and SNPs within the translated and non-translated regions of the VKORC1 gene have been shown to cause coumarin resistance and sensitivity,respectively. Besides the known CYP2C9 variants that affect coumarin metabolism, the haplotype VKORC1*2 representing a frequent SNP within the VKORC1 promoter has been identified as a major determinant of coumarin sensitivity,reducingVKORC1 enzyme activity to 50% of wild type. Homozygous carriers of the VKORC1*2 allele are strongly predisposed to coumarin sensitivity. Using individualized dose adaptation, a significant reduction of bleeding complications can be expected, especially in the initial drug saturation phase. Furthermore, concomitant application of low dose vitamin K may significantly reduce intra-individual coumarin dose variation and, thus, may stabilize oral anticoagulation therapy. The use of new pharmacogenetics-based dosing schemes and the concomitant application of low-dose vitamin K with coumarins will decidedly influence the current practice of oral anticoagulation and greatly improve coumarin drug safety.

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40

Nascimento, Jainara Santos do, Wilson Elias Rozo Núñez, Valmore Henrique Pereira dos Santos, Josefina Aleu, Sílvio Cunha y Eliane de Oliveira Silva. "Mapping the Biotransformation of Coumarins through Filamentous Fungi". Molecules 24, n.º 19 (29 de septiembre de 2019): 3531. http://dx.doi.org/10.3390/molecules24193531.

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Natural coumarins are present in remarkable amounts as secondary metabolites in edible and medicinal plants, where they display interesting bioactivities. Considering the wide enzymatic arsenal of filamentous fungi, studies on the biotransformation of coumarins using these microorganisms have great importance in green chemical derivatization. Several reports on the biotransformation of coumarins using fungi have highlighted the achievement of chemical analogs with high selectivity by using mild and ecofriendly conditions. Prompted by the enormous pharmacological, alimentary, and chemical interest in coumarin-like compounds, this study evaluated the biotransformation of nine coumarin scaffolds using Cunninghamella elegans ATCC 10028b and Aspergillus brasiliensis ATCC 16404. The chemical reactions which were catalyzed by the microorganisms were highly selective. Among the nine studied coumarins, only two of them were biotransformed. One of the coumarins, 7-hydroxy-2,3-dihydrocyclopenta[c]chromen-4(1H)-one, was biotransformed into the new 7,9-dihydroxy-2,3-dihydrocyclopenta[c]chromen-4(1H)-one, which was generated by selective hydroxylation in an unactivated carbon. Our results highlight some chemical features of coumarin cores that are important to biotransformation using filamentous fungi.

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41

Pratiwi, Dianti, Dila Qhoirul Nisa, Elsya Martia, Putri Wulanbirru y Syfa Dwi Andini. "Isolasi Senyawa Kumarin pada Tanaman". Syntax Idea 3, n.º 7 (19 de julio de 2021): 1576. http://dx.doi.org/10.36418/syntax-idea.v3i7.1375.

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Indonesia is a country rich in biodiversity. Of several plants that can be used as alternative medicine to treat disease. The efficacy of plants as medicine in health is related to plants having chemical compounds which are the result of secondary metabolites contained in these plants. One of the secondary metabolites in plants is coumarin. Coumarins can be found in almost all plants from roots, stems, leaves, flowers and fruit. The purpose of this study was to isolate and identify coumarin compounds contained in these plants. In the process of isolating coumarin compounds that can be done by several methods including extraction, phytochemical screening, fractionation, isolation of coumarins and identification of isolates. Plants containing coumarin compounds that were used in the isolation of coumarins that we reviewed were sundai lime peel (Citrus nobilis Lour), rambutan fruit seeds (Nephelium lappaceum L), water henna leaves (Impatiens Balsemina Linn), harp bark (Sandoricum koetjape) and Artemisia annua L.

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42

Cuzzocrea, Salvatore, Emanuela Mazzon, Carla Bevilaqua, Giuseppina Costantino, Domenico Britti, Giuseppe Mazzullo, Angela De Sarro y Achille P. Caputi. "Cloricromene, a coumarine derivative, protects against collagen-induced arthritis in Lewis rats". British Journal of Pharmacology 131, n.º 7 (diciembre de 2000): 1399–407. http://dx.doi.org/10.1038/sj.bjp.0703695.

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43

Frøland, Anders. "Studies on Dosage in Prophylactic Coumarine Treatment of Patients with Coronary Occlusion". Acta Medica Scandinavica 169, n.º 5 (24 de abril de 2009): 545–50. http://dx.doi.org/10.1111/j.0954-6820.1961.tb07864.x.

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44

Kiskan, Baris y Yusuf Yagci. "Self-healing of poly(propylene oxide)-polybenzoxazine thermosets by photoinduced coumarine dimerization". Journal of Polymer Science Part A: Polymer Chemistry 52, n.º 20 (25 de julio de 2014): 2911–18. http://dx.doi.org/10.1002/pola.27323.

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45

Lioret, Vivian, Yoann Rousselin y Richard A. Decréau. "Pyrene/coumarine-subphthalocyanine conjugates as light harvesting systems with intramolecular energy transfer". Dyes and Pigments 183 (diciembre de 2020): 108696. http://dx.doi.org/10.1016/j.dyepig.2020.108696.

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46

Tsuji, Eiichi, Kosuke Okazaki y Kei Takeda. "Crystal structures of rat catechol-O-methyltransferase complexed with coumarine-based inhibitor". Biochemical and Biophysical Research Communications 378, n.º 3 (enero de 2009): 494–97. http://dx.doi.org/10.1016/j.bbrc.2008.11.085.

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47

Ukirde, R. D., R. B. Patil y S. D. Sawant. "Design, Synthesis and Evaluation of Antioxidant Activity of Some Coumarin Derivatives". Asian Journal of Organic & Medicinal Chemistry 4, n.º 3 (30 de septiembre de 2019): 138–43. http://dx.doi.org/10.14233/ajomc.2019.ajomc-p172.

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Coumarin derivatives are an important class of heterocyclic compounds, specifically 4-amino substituted coumarins with antioxidant, anticancer activities. The above observations prompted us to synthesize new coumarins with various substitutions. The starting material 4-chloro-2H-chromen-2-one was synthesized by refluxing a mixture of 4-hydroxy-2H-chromen-2-one in phosphoryl chloride. The 4-substituted amine derivatives of coumarin were synthesized by refluxing 4-chloro-2H-chromen-2- one with 4-substituted amines and anhydrous K2CO3 and methanol. All the eleven 4-substituted amine derivatives of coumarin were synthesized by replacing chloro group with different amines. These coumarin derivatives were evaluated for in vitro antioxidant activity using quercetin as standard.

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48

Pandya, Mahesh K., Tapan H. Parekh, Mehulsinh R. Chhasatia y Nileshkumar D. Vala. "Synthesis and characterization of some novel coumarin based various 2-aryl-pyrido [3,2-c] coumarins". Journal of Drug Delivery and Therapeutics 10, n.º 2 (15 de marzo de 2020): 158–63. http://dx.doi.org/10.22270/jddt.v10i2.3933.

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A survey of the literature reveals that the number of coumarin derivatives having heterocyclic moieties either as substituent groups or fused with parent coumarin nucleus possesses a variety of functions and are widely used in drugs and dyes. Because of this wide utility, the synthesis of coumarin has remained a subject of active interest. Looking at the importance of these heterocoumarins and with a view to exploring new methods of their synthesis, the present work was undertaken and this synthesis deals with various 2-aryl-pyrido [3,2-c] coumarins. The compounds have been synthesized by reacting Mannich bases of various 4-hydroxy coumarins with pyridinium salts of various aroyl methyl bromides in the presence of ammonium acetate and acetic acid. All the compounds synthesized have been characterized by analytical and spectral data. Keywords: Pyrido, Coumarins, Krohanke’s reaction.

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49

Sanaryh Mohammed Al-awad, Leaqaa Abdalredha raheem y Ausama Ayob Jaccob. "Synthesis and Pharmacological Evaluation of Novel Coumarin Derivatives". International Journal of Research in Pharmaceutical Sciences 11, n.º 1 (27 de enero de 2020): 865–74. http://dx.doi.org/10.26452/ijrps.v11i1.1908.

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The current work focuses on new architecture, synthesis of coumarin-oxadiazole hybrid derivative products as both these (coumarin ring and oxadiazole) have a wide variety of biological behavior, Compounds containing the nucleus of coumarin (2H-1-benzopyran-2-one) are an interesting class of hetero cycles which hold an important role in the field of natural ingredients and synthetic organic chemistry. It has been exciting medicinal chemists to study native coumarins or synthetic analogs for their application for decades. And they can be further modified to synthesize more effective and potent drugs. Compounds have been characterized by spectrophotometry of physicochemical properties and their structures verified by infrared spectroscopy (FTIR) and nuclear magnetic resonance (1H-NMR) Such new derivatives of coumarinyl-oxadiazole was qualified to estimate the lethal dose, anticancer, anticoagulant and antioxidant activity. Their pharmacological properties depend on their pattern of substitution, compound S4F proved significant anticoagulant activity in concentration (50, 100, 200 mg/ml) similar for heparin, and monitor the coagulation effect on plasma, while compound S4CO give significant anticancer activity against MCF-7 a breast cancer cell. Specific compounds have strong antioxidants with the effective action of radical scavengers; the S4Cl compound with IC50 1.49 is the most potent antioxidant activity note. Basically, all the formulations tested reported satisfactory behavior. The review shows that varieties of coumarin derivatives have synthesized and shown anti-cancer, antioxidant and anti-coagulant potentials. These derivatives synthesis and its biological assay can be further modified in the future to improve the anti-cancer, anti-oxidant and anticoagulant potentials of the versatile coumarin nucleus.

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50

Nowacka, Maria, Tomasz Makowski y Anna Kowalewska. "Hybrid Fluorescent Poly(silsesquioxanes) with Amide- and Triazole-Containing Side Groups for Light Harvesting and Cation Sensing". Materials 13, n.º 20 (10 de octubre de 2020): 4491. http://dx.doi.org/10.3390/ma13204491.

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Hybrid polymers containing pyrene (Py) units bound to linear poly(silsesquioxane) (LPSQ) chains through flexible linkers containing heteroatoms (S, N, O) (LPSQ-triazole-Py and LPSQ-amide-Py) exhibit intense fluorescence emission, both in very diluted solutions (c = 10−8 mol/L) and in the solid state. The materials are thermally stable and exhibit good thin film forming abilities. Their optical and physicochemical properties were found to be strongly dependent on the structure of the side chains. Comparative studies with octahedral silsesquioxane (POSS) analogues (POSS-triazole-Py and POSS-amide-Py) emphasized the role of the specific double-strand architecture of the LPSQ backbone and distribution of side Py groups for their photo-luminescent properties. The new hybrid materials were tested as fluorescence energy donors to red-emitting dyes (Nile Red and Coumarine 6). All the silsesquioxanes studied were found to be able to transfer FL emission energy to Coumarin 6, irrespectively of their spatial structure. However, due to the differences in the wavelength range of FL emission, only LPSQ-triazole-Py were able to act as energy donors to Nile Red. The Py-grafted LPSQ may be also applied for development of soluble and highly emissive chemosensors. Their fluorescent nature was explored for the detection of Cu(II), Fe(III), Co(II), Ag(I), Hg(II), Mg(II), Ca(II), Pb(II) and Zn(II). The morphology of the side chains and hydrogen-bonding interactions influenced the sensing capacity of all the studied materials.

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