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Singh, Jagwinder y Shivani Saini. "Importance of CEM in CRM-CL framework". Journal of Modelling in Management 11, n.º 1 (8 de febrero de 2016): 91–115. http://dx.doi.org/10.1108/jm2-05-2014-0038.
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Purpose – The purpose of this paper is to propose a model to understand the role of customer relationship management efforts in building, sustaining and enhancing customer loyalty (CL). Design/methodology/approach – This paper reviews extant literature in customer relationship management (CRM), customer experience management (CEM) and CL, with a particular emphasis on exploring the relationships between these proposed domains. Findings – The CRM efforts, customer acquisition, retention and experience, are suggested to have positive influence on attitudinal and behavioural loyalty. A model for testing the associations of customer relationship efforts to various forms of CL, including the satisfaction, trust and commitment as mediators in CRM-CL link are proposed. Research limitations/implications – This paper represents a first attempt to build and propose a conceptual framework of CRM–CL. This is an indicative research than a conclusive one. Therefore, research implications are to perform the empirical testing of model in different business environments. Practical implications – This application of proposed model in a business environment will be helpful for the marketing practitioners to well understand the customers’ changing expectations as well as to prioritize the marketing functions. The emphasis and right calculation about the acquisition, retention and experience decisions would be helpful to marketers to know the expected profitability of customers. Originality/value – This is the first paper to provide a comprehensive integrated model of CRM and CL to understand the effects of CRM efforts on various forms of CL.
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Al-Zadjali, Mohamed y Kamla Ali Al-Busaidi. "Empowering CRM Through Business Intelligence Applications". International Journal of Knowledge Management 14, n.º 4 (octubre de 2018): 68–87. http://dx.doi.org/10.4018/ijkm.2018100105.
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The application of business intelligence (BI) techniques for knowledge discovery and decision support empowers organizations in different functions. This article examines the impacts of BI on customer relationship management (CRM) functions (marketing, sales and customer services) in the telecommunications sector. The literature found that BI application in CRM in a telecommunications context is limited but necessary due to the high rate of competition between service providers and the massive data generated by subscribers. This study surveyed employees' perspectives from telecommunications companies in Oman, and results demonstrated mixed impacts. First, the results showed that implementing BI in marketing has a positive impact on business processes values, customer values, but a negative impact on employees' values. Second, implementing BI in sales has a positive impact on financial values and employees' values, but a negative impact on business processes values, and customers' values. Finally, implementing BI in customer service has a positive impact on employees' values. The study provides valuable guidelines for practitioners in the area of CRM, BI, and telecommunications to help understand why to invest in BI in specific CRM functions.
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Becker, Jan U., Goetz Greve y Sönke Albers. "Left Behind Expectations - How to Prevent CRM Implementations from Failing". GfK Marketing Intelligence Review 2, n.º 2 (1 de noviembre de 2010): 34–41. http://dx.doi.org/10.2478/gfkmir-2014-0061.
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Abstract This article discusses performance drivers of CRM projects and is particularly relevant for managers seeking to optimize their companies CRM efforts. Despite the billions of dollars that have been spent on the implementation of customer relationship management (CRM) systems, many of the adopting companies are unhappy with the results. This can be due to two reasons: first, either the CRM projects are poorly implemented and thus do not perform accordingly, or, second, companies expect too much from CRM systems. This research examines how technological and organizational implementations as well as internal support affect the objectives of CRM with regard to initiating, maintaining, and retaining customer relationships. The results indicate that internal support is an important factor for the performance of CRM implementation. Further, it helps to have a clear focus for a CRM system to specifically address diverse functions such as the acquisition, maintenance, and retention of customers and to tailor implementation effort to the needs of the major functions
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Liu, Yi-Yuan. "Does Technology Acceptance Change the Way from CRM to Customer Loyalty?" International Journal of E-Services and Mobile Applications 2, n.º 3 (julio de 2010): 44–56. http://dx.doi.org/10.4018/jesma.2010070103.
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This study explores the moderating effect of technology acceptance on the relationship between customer relationship management (CRM) in terms of distribution and tailor-made functions and customer loyalty in the banking industry. The author uses LISREL two-group path analysis to find the variances between high and low technology acceptance. Data collected from the customers of nine retail banks show that commitments have a mediating effect on the relationship between the tailor-made function of CRM and customer loyalty, while technology acceptance has significant effects on both relationships between the two functions of CRM and continuance commitment.
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Farid Shamsudin, Mohd, Mohd Fikri Ishak, Muhammad Asyraf Hashim, Milad Abdel Nabi, Mohd Faizun Mohamad Yazid y Anis Abdul Razak. "PRELIMINARY ANALYSIS ON RELATIONSHIP OF CRM FUNCTIONS IMPLEMENTATION TOWARDS FIRM’S BUSINESS PERFORMANCE". Humanities & Social Sciences Reviews 7, n.º 1 (15 de abril de 2019): 113–20. http://dx.doi.org/10.18510/hssr.2019.7114.
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Purpose of Study: The purpose of this preliminary study is to determine the reliability and validity of the instrument used and feasible for full-scale analysis of the aforementioned studied phenomenon. PLS-SEM is employed in this preliminary study that utilised SmartPLS 3.0.
Methodology: Drawing on RBV (resource-based view) the implementation of customer relationship management (CRM) functions in hotel industry had become a central strategy in determining competitive advantage. Empirical studies had documented that small and medium hotels had also embraced on customer-centric business practice that endures CRM functions as their strategy in sustaining competitive advantage. Indeed, they inclines to implement elementary CRM functions that leverage the IBT’s (internet-based technologies) of hotel website. CRM functions is regarded as firms’ resource that effectively deployed may lead to competitive advantage that portray in positive business performance. A total of seventy-five respondents (managers and owners) of small and medium hotels managers and owners from Greater Kuala Lumpur participated in the survey realised through convenient sampling method.
Main Findings: The result of PLS-SEM analysis on measurement model had showed a robust analysis of internal reliability and validity. Assessment of items and constructs included in the study exhibits a good internal consistency and valid, thus, reflects an acceptable research model that are feasible and ready a full-scale analysis.
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Kamalova, G. B., N. A. Vodolazkina y K. I. Aklbekov. "INFORMATION CRM SYSTEMS IN ORGANIZATIONAL AND MANAGEMENT ACTIVITIES OF TECHNICIANS-PROGRAMMERS". BULLETIN Series of Physics & Mathematical Sciences 71, n.º 3 (30 de septiembre de 2020): 220–24. http://dx.doi.org/10.51889/2020-3.1728-7901.33.
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Allocation of organizational and managerial activity as an independent type in the structure of the professional activity of a technician-programmer, including the implementation of such organizational and managerial functions as planning and teamwork, making and implementing managerial decisions, establishing and maintaining internal and external communications, evaluating and developing professional and career advancement, project management, will allow him to effectively organize activities, both his own and the division of the organization entrusted to him. One of the main organizational and managerial functions is the functions of customer relationship management. These tasks are implemented in CRM systems. To automate the organizational and management activities of specialists of various levels, including technicians-programmers, today, in the context of the rapid development of technology and technology, large-scale digitalization, it is advisable to use such information systems. Possessing high technical and functional capabilities, they allow to accumulate and quickly process huge volumes of various information, to make decisions based on this information adequately and quickly. However, ready-made CRM systems are mostly paid and overloaded with unnecessary functionality, since they are only one of the components of a giant corporate system. Practice shows that small companies are limited to the minimum required set of functions implemented in such CRM systems, so it is often easier to develop their own CRM systems for their processes. In this article the requirements for such systems of automation of organizational and management activities of technicians-programmers and its functional structure are describes.
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O’Neill, Ryan S., Todd A. Schoborg y Nasser M. Rusan. "Same but different: pleiotropy in centrosome-related microcephaly". Molecular Biology of the Cell 29, n.º 3 (febrero de 2018): 241–46. http://dx.doi.org/10.1091/mbc.e17-03-0192.
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An intimate link between centrosome function and neurogenesis is revealed by the identification of many genes with centrosome-associated functions that are mutated in microcephaly disorders. Consistent with the major role of the centrosome in mitosis, mutations in these centrosome-related microcephaly (CRM) genes are thought to affect neurogenesis by depleting the pool of neural progenitor cells, primarily through apoptosis as a consequence of mitotic failure or premature differentiation as a consequence of cell cycle delay and randomization of spindle orientation. However, as suggested by the wide range of microcephaly phenotypes and the multifunctional nature of many CRM proteins, this picture of CRM gene function is incomplete. Here, we explore several examples of CRM genes pointing to additional functions that contribute to microcephaly, including regulation of cell cycle signaling, actin cytoskeleton, and Hippo pathway proteins, as well as functions in postmitotic neurons and glia. As these examples are likely just the tip of the iceberg, further exploration of the roles of microcephaly-related genes are certain to reveal additional unforeseen functions important for neurodevelopment.
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Lipiäinen, Heini Sisko Maarit. "CRM in the digital age: implementation of CRM in three contemporary B2B firms". Journal of Systems and Information Technology 17, n.º 1 (9 de marzo de 2015): 2–19. http://dx.doi.org/10.1108/jsit-06-2014-0044.
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Purpose – The purpose of this study was to contribute to the current discussion on digitization in companies’ marketing from a customer relationship management (CRM) perspective by examining the role and objectives of CRM and the exploitation of social media to serve the objectives of CRM in contemporary business-to-business (B2B) companies. Design/methodology/approach – The data are collected through semi-structured themed interviews with key marketing/sales managers from three B2B firms. Findings – CRM seems to be moving closer to the company’s core activity and becoming everybody’s business to a greater extent than ever before, but its main goal, to enhance customer relationships, will not necessarily change. Understanding the customer is vital and requires different functions to cooperate closely to ensure the firm has the best possible understanding of its customers. Public social media tools played almost no part in CRM, but closed social media systems might have potential in the future. Research limitations/implications – The chosen research approach limits the generalization of the results. Practical implications – It seems likely that firms will benefit from a collaborative working style over the traditional silo approaches. For B2B firms, public social media does not seems to be the most suitable source to serve CRM but private social media channels might have potential in the future. Originality/value – The lack of empirical examination of the change from company ecosystem to customer ecosystem from a CRM perspective, and the lack of research on social media for CRM in the B2B context, determines the purpose of this study. Furthermore, digitization is a rather new and unstructured phenomenon and many companies are still considering how to reconcile to it.
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Berliandaldo, Mahardhika, Achmad Chodiq, Sutarno Sutarno y Heru Eko Prasetyo. "IMPLEMENTASI MODEL CUSTOMER RELATIONSHIP MANAGEMENT UNTUK FUNGSI LAYANAN UMUM PADA ERA TATANAN BARU". Journal Publicuho 4, n.º 2 (20 de abril de 2021): 225. http://dx.doi.org/10.35817/jpu.v4i2.17703.
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Customer Relationship Management or CRM is a new approach to managing relationships between organizations and customers. In the era of the new order, especially during the current Covid-19 pandemic, digitizing public service functions carried out by the General Bureau of LIPI will play an important role in supporting the smooth running of the organization's operations. Customer satisfaction is highly dependent on the service process provided by executing service functions. In order for public service functions to run properly, it is necessary to carry out analysis in exploiting customer data in order to create increased value for the organization and customers by using Value Chain model analysis. Furthermore, to describe the implementation of CRM in public service functions, the implementation of the model applied is to use Payne's five-process model. This model describes the five core processes in CRM, namely the strategy development process, the value creation process, the multichannel integration process, the performance appraisal process and the information management process. The strategy for implementing this model is used so that the results obtained can run as expected. That way, customer satisfaction will be a top priority in implementing CRM in the general service function at LIPI.
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Singh, Anurag. "Drive Customer Experience for Relationship Management through Actionable Social CRM". International Journal of Customer Relationship Marketing and Management 6, n.º 4 (octubre de 2015): 57–76. http://dx.doi.org/10.4018/ijcrmm.2015100104.
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Social CRM is gradually stirring into the conventional business strategies in spite of much hue and cry for unsecured process and stepping. Seeing people networked for the sustainable advantages of the companies, they are now being enabled by web 2.0 technologies. Web 2.0 technology is a hopeful breakthrough to modernize the CRM. In the process and implementation of the strategy, few of corporate giants have already jumped into the social CRM, and few are in the process of comprehension and the adoption. This paper aims to portray the process of social media in monitoring and fostering the relationship. The study talks about the detailed functioning of social CRM after having the investigation of the present famous social CRM process. Further an initiative is taken to explore the social CRM practices in Indian industries and to explain other functions of SCRM through cases, for capability building and healthy management.
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Ou, Yan Qun, Li Zhou y Yu Ping Fang. "Application Research of Data Warehouse in CRM". Advanced Materials Research 591-593 (noviembre de 2012): 854–57. http://dx.doi.org/10.4028/www.scientific.net/amr.591-593.854.
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Customer relationship management (CRM) is an integral part in the manufacturing enterprise information. The content of CRM is based on customer information and business transaction data, and using computer information technology to deeply analysis massive data of data warehouse. The purpose is to identify customers’ different features and analyze customer behaviors, then dig out the information of commercial value to help business planning and decision-making related business activities. The thesis introduces the system of the CRM based on Data Warehouse: to describe and predict the model of enterprise customers’ behavior by data warehouse and data mining theory and technology. The purpose is to optimize the entire CRM process, and effectively realize customer relationship management ultimately. Research and analysis of data warehouse in CRM to achieve other functions such as customer behavior analysis, key customers found and market performance evaluation. It can further analyze amounts of customer information in data warehouse, acquire efficient information about how to enhance the advantages of market competition, make the concept and goal of CRM can be achieved and satisfy the demand and challenge in modern e-commerce times. It can help enterprises increase market decision-making ability, gain competitive advantages and perfect business plan.
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Zhang, Qiang, Lan Shen, Deyong Ren, Jiang Hu, Li Zhu, Zhenyu Gao, Guangheng Zhang, Longbiao Guo, Dali Zeng y Qian Qian. "Characterization of the CRM Gene Family and Elucidating the Function of OsCFM2 in Rice". Biomolecules 10, n.º 2 (18 de febrero de 2020): 327. http://dx.doi.org/10.3390/biom10020327.
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The chloroplast RNA splicing and ribosome maturation (CRM) domain-containing proteins regulate the expression of chloroplast or mitochondrial genes that influence plant growth and development. Although 14 CRM domain proteins have previously been identified in rice, there are few studies of these gene expression patterns in various tissues and under abiotic stress. In our study, we found that 14 CRM domain-containing proteins have a conservative motif1. Under salt stress, the expression levels of 14 CRM genes were downregulated. However, under drought and cold stress, the expression level of some CRM genes was increased. The analysis of gene expression patterns showed that 14 CRM genes were expressed in all tissues but especially highly expressed in leaves. In addition, we analyzed the functions of OsCFM2 and found that this protein influences chloroplast development by regulating the splicing of a group I and five group II introns. Our study provides information for the function analysis of CRM domain-containing proteins in rice.
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Mayhew, David L., Jerry L. Mayhew y John S. Ware. "Effects of Long-term Creatine Supplementation on Liver and Kidney Functions in American College Football Players". International Journal of Sport Nutrition and Exercise Metabolism 12, n.º 4 (diciembre de 2002): 453–60. http://dx.doi.org/10.1123/ijsnem.12.4.453.
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The purpose of this study was to determine the effect of long-term Cr supplementation on blood parameters reflecting liver and kidney function. Twenty-three members of an NCAA Division II American football team (ages = 19–24 years) with at least 2 years of strength training experience were divided into a Cr monohydrate group (CrM, n = 10) in which they voluntarily and spontaneously ingested creatine, and a control group (n = 13) in which they took no supplements. Individuals in the CrM group averaged regular daily consumption of 5 to 20 g (mean ± SD = 13.9 ± 5.8 g) for 0.25 to 5.6 years (2.9 ± 1.8 years). Venous blood analysis for serum albumin, alkaline phosphatase, alanine aminotransferase, aspartate aminotransferase, bilirubin, urea, and creatinine produced no significant differences between groups. Creatinine clearance was estimated from serum creatinine and was not significantly different between groups. Within the CrM group, correlations between all blood parameters and either daily dosage or duration of supplementation were nonsignificant. Therefore, it appears that oral supplementation with CrM has no long-term detrimental effects on kidney or liver functions in highly trained college athletes in the absence of other nutritional supplements.
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Zhang, Qiang, Lan Shen, Zhongwei Wang, Guanglian Hu, Deyong Ren, Jiang Hu, Li Zhu et al. "OsCAF1, a CRM Domain Containing Protein, Influences Chloroplast Development". International Journal of Molecular Sciences 20, n.º 18 (6 de septiembre de 2019): 4386. http://dx.doi.org/10.3390/ijms20184386.
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The chloroplast RNA splicing and ribosome maturation (CRM) domain proteins are involved in the splicing of chloroplast gene introns. Numerous CRM domain proteins have been reported to play key roles in chloroplast development in several plant species. However, the functions of CRM domain proteins in chloroplast development in rice remain poorly understood. In the study, we generated oscaf1 albino mutants, which eventually died at the seedling stage, through the editing of OsCAF1 with two CRM domains using CRISPR/Cas9 technology. The mesophyll cells in oscaf1 mutant had decreased chloroplast numbers and damaged chloroplast structures. OsCAF1 was located in the chloroplast, and transcripts revealed high levels in green tissues. In addition, the OsCAF1 promoted the splicing of group IIA and group IIB introns, unlike orthologous proteins of AtCAF1 and ZmCAF1, which only affected the splicing of subgroup IIB introns. We also observed that the C-terminal of OsCAF1 interacts with OsCRS2, and OsCAF1–OsCRS2 complex may participate in the splicing of group IIA and group IIB introns in rice chloroplasts. OsCAF1 regulates chloroplast development by influencing the splicing of group II introns.
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Shutts, G. J. y T. N. Palmer. "Convective Forcing Fluctuations in a Cloud-Resolving Model: Relevance to the Stochastic Parameterization Problem". Journal of Climate 20, n.º 2 (15 de enero de 2007): 187–202. http://dx.doi.org/10.1175/jcli3954.1.
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Abstract Idealized cloud-resolving model (CRM) simulations spanning a large part of the tropical atmosphere are used to evaluate the extent to which deterministic convective parameterizations fail to capture the statistical fluctuations in deep-convective forcing, and to provide probability distribution functions that may be used in stochastic parameterization schemes for global weather and climate models. A coarse-graining methodology is employed to deduce an effective convective warming rate appropriate to the grid scale of a forecast model, and a convective parameterization scheme is used to bin these computed tendencies into different ranges of convective forcing strength. The dependence of the probability distribution functions for the coarse-grained temperature tendency on parameterized tendency is then examined. An aquaplanet simulation using a climate model, configured with similar horizontal resolution to that of the coarse-grained CRM fields, was used to compare temperature tendency variation (less the effect of advection and radiation) with that deduced as an effective forcing function from the CRM. The coarse-grained temperature tendency of the CRM is found to have a substantially broader probability distribution function than the equivalent quantity in the climate model. The CRM-based probability distribution functions of precipitation rate and convective warming are related to the statistical mechanics theory of Craig and Cohen and the “stochastic physics” scheme of Buizza et al. It is found that the standard deviation of the coarse-grained effective convective warming is an approximately linear function of its mean, thereby providing some support for the Buizza et al. scheme, used operationally by ECMWF.
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Parry, William. "DYNAMICAL ZETA FUNCTIONS FOR PIECEWISE MONOTONE MAPS OF THE INTERVAL (CRM Monograph Series 4)". Bulletin of the London Mathematical Society 28, n.º 3 (mayo de 1996): 327–29. http://dx.doi.org/10.1112/blms/28.3.327.
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Dos Santos, José Gonalo. "Data Mining as Support for Customer Relationship Management: A Case Study". INTERNATIONAL JOURNAL OF COMPUTERS & TECHNOLOGY 13, n.º 11 (30 de noviembre de 2014): 5113–20. http://dx.doi.org/10.24297/ijct.v13i11.2780.
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This article describes the data mining application to CRM - Customer Relationship Management. The article starts with an introduction showing the importance of the CRM strategy for the company, after it’s introduced the theoretical about CRM, Knowledge Discovery Database and its stages, with emphasis to the mining stage and concludes with presentation of a case study and the conclusions. For the case study it was developed a prototype of an information system of a bookstore, it was implemented, beyond the conventional functions, the association rules discovery algorithm. The implementation of the data mining technique allowed to the system supply support so that the user knows better the client, becoming possible the application of the strategy of CRM.
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Pauls, Stefan, Debbie K. Goode, Libero Petrone, Paola Oliveri y Greg Elgar. "Evolution of lineage-specific functions in ancient cis -regulatory modules". Open Biology 5, n.º 11 (noviembre de 2015): 150079. http://dx.doi.org/10.1098/rsob.150079.
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Morphological evolution is driven both by coding sequence variation and by changes in regulatory sequences. However, how cis -regulatory modules (CRMs) evolve to generate entirely novel expression domains is largely unknown. Here, we reconstruct the evolutionary history of a lens enhancer located within a CRM that not only predates the lens, a vertebrate innovation, but bilaterian animals in general. Alignments of orthologous sequences from different deuterostomes sub-divide the CRM into a deeply conserved core and a more divergent flanking region. We demonstrate that all deuterostome flanking regions, including invertebrate sequences, activate gene expression in the zebrafish lens through the same ancient cluster of activator sites. However, levels of gene expression vary between species due to the presence of repressor motifs in flanking region and core. These repressor motifs are responsible for the relatively weak enhancer activity of tetrapod flanking regions. Ray-finned fish, however, have gained two additional lineage-specific activator motifs which in combination with the ancient cluster of activators and the core constitute a potent lens enhancer. The exploitation and modification of existing regulatory potential in flanking regions but not in the highly conserved core might represent a more general model for the emergence of novel regulatory functions in complex CRMs.
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Ren, Wen Ju, Ya Hui Hu, Tong Jian Zhang y Ming Xing Li. "The Correlation between CRM Strategy for City Commercial Banks and Core Competency Cultivation-Evidence from China". Advanced Materials Research 452-453 (enero de 2012): 980–85. http://dx.doi.org/10.4028/www.scientific.net/amr.452-453.980.
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In order to reveal the incentive functions of customer relationship management (CRM) strategy in the process of core competency cultivation, the structure equation modeling (SEM) is used in this paper. By research hypothesis, model deduction, reliability and verification test, and model checking, SEM can effectively reveal the correlation between CRM strategy and core competence cultivation in Chinese city commercial banks. For illustration, the collected copies are 300 banks, and 298 copies are valid. The sample ratio of sample data and indicators is 6:1, which meets the basic requirements for structural equation test. The empirical results show that the reliability and validity in the research measurement model are quite well and the reliability and validity in the model are also quite well. The empirical research has revealed the CRM-related strategy microcosmic mechanism in core competency cultivation, which can provide the effective theoretical references and support for banks to further strengthen CRM strategy and raise management efficiency.
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Yulistiani, Dwi, Wisri Puastuti, Budi Haryanto, Agung Purnomoadi, M. Kurihara y Amlius Thalib. "COMPLETE RUMEN MODIFIER SUPPLEMENTATION IN CORN COB SILAGE BASAL DIET OF LAMB REDUCES METHANE EMISSION". Indonesian Journal of Agricultural Science 18, n.º 1 (14 de septiembre de 2017): 33. http://dx.doi.org/10.21082/ijas.v18n1.2017.p33-42.
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<p>Feeding animal with fibrous materials such as corn cob will emit methane. Complete rumen modifier (CRM) is an improved feed additive comprised a mixture of Sapindus rarak, sesbania, albizia leaves and minerals that functions as a methane inhibitor. The study aimed to determine the effect of CRM supplementation on the feed intake, nutrient digestibility, rumen fermentation, methane emission and growth of lambs. The experiment was designed in a complete randomized block, four levels of CRM (0%, 1%, 2%, and 3%), six group of 24 male lambs per treatment based on the body weight. Basal diet used was corn cob silage ad libitum and concentrate (500 g/day) as a supplement. The results showed that CRM supplementation did not affect feed consumption and average daily gain, but significantly decreased the dry matter, as well as organic matter and protein digestibility. The neutral detergent fiber (NDF) and acid detergent fiber (ADF) digestibility linearly decreased with increasing level of CRM. Ruminal pH, ammonia concentration and volatile fatty acid (VFA) concentration were not affected by the CRM supplementation. Methane production expressed in kJ/MJ gross energy (GE) or digestible energy (DE) intake significantly decreased by 32% at the 2–3% CRM supplementation and reduced by 39% when methane production was expressed in g/kg digested NDF. It can be concluded that 2% CRM supplementation in the corn cob basal diet did not affect nutrient intake and growth rate of the lamb, as well as rumen fermentation. The study suggests that CRM is an environmentally friendly feed additive for lamb</p>
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Nehari-Talet, Amine, Samer Alhawari y Haroun Alryalat. "The Outcome of Knowledge Process for Customer of Jordanian Companies on the Achievement of Customer Knowledge Retention". International Journal of Knowledge Management 6, n.º 1 (enero de 2010): 44–61. http://dx.doi.org/10.4018/jkm.2010103003.
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Organizations have increasingly recognized the importance of managing customer relationships, and Knowledge Management (KM) from the perspective of a process approaches assure positive impact on customer retention. Many organizations are turning to Customer Relationship Management (CRM) to better serve customers and facilitate closer relationships. This paper investigates how Knowledge Process for customers is used in practice by Jordanian companies to achieve Customer Knowledge Retention. The current practice is based on the data collected from 156, randomly drawn and reported from a survey of CRM applications and evaluation of CRM analytical functions provided by three software business solution companies working in the CRM area, and four companies that used the CRM system. Based on data collected from the companies, results from the analysis indicated that the knowledge process for customers had a positive effect on customer knowledge retention. The paper also verified the hypotheses of the effect of knowledge processes for customers on customer retention. The findings shed light on the potential relationship between the knowledge processes for customers and customer retention. It also provides guidance for the Information Technology (IT) industry as to how an analytical knowledge process for customers should be taken into account in developing countries to support to achieve customer knowledge retention due to cultural, social and educational differences.
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Asakura, Yukari y Alice Barkan. "A CRM Domain Protein Functions Dually in Group I and Group II Intron Splicing in Land Plant Chloroplasts". Plant Cell 19, n.º 12 (diciembre de 2007): 3864–75. http://dx.doi.org/10.1105/tpc.107.055160.
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Law, J. Randolph y Terry J. McFadden. "Training and Evaluating Team Process Skills in the Commercial Aviation Environment". Proceedings of the Human Factors Society Annual Meeting 36, n.º 17 (octubre de 1992): 1346–50. http://dx.doi.org/10.1518/107118192786749441.
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The majority of aviation incidents and accidents are attributable to human error (Billings & Reynard, 1984). Most of these human errors involve the ineffective use of team process factors, which are often referred to as Crew Resource Management (CRM) skills in the commercial aviation literature (Helmreich & Foushee, in press). In addition to these applied concerns, a revised version of McGrath's (1964) theory of group performance (Foushee & Helmreich, 1988) suggests that one must analyze the process (i.e., team process) by which a group's inputs (e.g., personality, attitudes) are transformed into group outcomes (e.g., task performance, mission safety) in order to understand how a task-oriented group functions. Therefore, team process attracts theoretical as well as practical interest. The NASA/UT/FAA Line/LOS Checklist (LLC: Helmreich, Wilhelm, Kello, Taggart, & Butler 1991) is one measure of team process that has proven useful in assessing CRM skills in training and in actual Line operations. This paper briefly reviews concepts in team process and summarizes the LLC research findings pertaining to the use of CRM skills in commercial aviation.
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., Medha. "Customer Segmentation using Data Mining Techinique". International Journal for Research in Applied Science and Engineering Technology 9, n.º VII (15 de julio de 2021): 996–98. http://dx.doi.org/10.22214/ijraset.2021.36105.
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Data mining technique can help implementing customer relationship management dimensions namely customer identification, customer attraction, customer retention and customer development . Various Data mining functions can be used to implement CRM elements . This review paper is focused on one of the element of customer identification that is customer segmentation and its implentation using K-means clustering technique. It discuses in breif about the K-means Algorithm.
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Yang, Zhi Gang, Li Sun y Xiao Yang Yu. "Design and Implementation of a Data Warehouse ETL Tray Program". Applied Mechanics and Materials 385-386 (agosto de 2013): 1684–88. http://dx.doi.org/10.4028/www.scientific.net/amm.385-386.1684.
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This paper presents an ETL system for a data warehouse designed for a PVC profile manufacturing enterprise. The system implements the data extraction, data transformation and load from the data sources of ERP system, CRM system and production line operation data collection system. The ETL requirements are discussed. The system design and implementation methods, including system structure, functions, data processing methods as well as tray program implementation are addressed.
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Tarasova, Anna, Anna Polukhina y Avdykerim Arnaberdiyev. "Information Support for Travel Agency Performance". International Journal of Recent Contributions from Engineering, Science & IT (iJES) 8, n.º 4 (18 de diciembre de 2020): 69. http://dx.doi.org/10.3991/ijes.v8i4.17669.
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<p>Internet technologies create new platforms for the sale of goods and services, however, their emergence arise new issues of how to attract and retain users. Modern Internet users enjoy freedom of choice, they can easily find travel services, or skip them just by closing the browser tab. That is how Customer Relationship Management (CRM) systems were introduced to build and manage efficiently good user relationships. This article discusses the main functions of CRM, according to the classification of The Center for Research on Information Technology and Organizations (the University of California, Irvine, USA) and considers the potentials of CRM systems on the market for large and small companies.</p><p> </p><p>The objective of the paper is to research information technologies that help to attract, retain and work with clients in travel agencies, as well as technologies that open up new platforms for the sale of tourism products, namely online sales. The article also investigates the impact the Internet technologies have on various industries, in particular on the tourism industry.</p>
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Arakawa, Yuya, Yuya Sugahara, Michiko Matsushita, Yuki Moriguchi, Hisashi Shimohiro, Mayumi Nakagawa y Kenji Iijima. "Factor XII Osaka: Abnormal factor XII with partially defective prekallikrein cleavage activity". Thrombosis and Haemostasis 105, n.º 03 (2011): 473–78. http://dx.doi.org/10.1160/th10-02-0123.
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SummaryA healthy Japanese male had reduced factor XII (FXII) activity (35%) in contrast to normal antigen levels (81%). The F12 of this proband had a 9775G to C mutation in exon 10 and an 11276G to A mutation in exon 13 that resulted in two amino acid substitutions of Ala324Pro (GCG→CCG) in the proline-rich connecting region and Gly531Glu (GGG→GAG) near the active Ser544 in the catalytic domain. His father had the nucleotide 46T/T and a heterozygous 9775G/C mutation. The FXII activity (32%) and antigen level (38%) of the father were about half that of normal individuals with 46T/T, suggesting a heterozygous cross reacting material (CRM)-negative deficiency. His mother had a 46C/T and heterozygous 11276G/A mutation, and 80% FXII activity was incompatible with the corresponding antigen level (125%), suggesting a heterozygous CRM-positive deficiency. The substitution of Ala324Pro probably caused the CRM-negative mutation and the Gly531Glu caused the CRM-positive mutation. We developed three methods based on chromogenic substrates to assay the distinct functions of FXII, namely its autoactivation on a negatively charged surface, activation by kallikrein cleavage and the prekallikrein cleavage activity of FXIIa. The ratios of autoactivated FXIIa/FXII antigen (0.80–1.10) and of kallikrein-induced FXIIa/FXII antigen (0.86–1.00) in plasma from the proband were within normal ranges, whereas those of FXIIa-induced kallikrein/FXII antigen were reduced to 0.41–0.45. In conclusion, the 9775G to C and 11276G to A mutations of F12 led to a CRM-negative and -positive FXII deficiency, and the F12 with 11276A produced a dys-functional type of FXII with a partial defect (0.41–0.45) in prekallikrein cleavage activity.
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Lau, Henry, Dilupa Nakandala, Premaratne Samaranayake y Paul Shum. "A hybrid multi-criteria decision model for supporting customer-focused profitability analysis". Industrial Management & Data Systems 116, n.º 6 (11 de julio de 2016): 1105–30. http://dx.doi.org/10.1108/imds-10-2015-0410.
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Purpose – Strategic analysis of customer profitability for assessing market segmentation and reconfiguring customer relationship management (CRM) activities remains the key factor for achieving high return on CRM investment. The purpose of this paper is to map the profit-based ranking of corporate customers into the current market segments, with a view of determining the relative profitability of each market segment. Design/methodology/approach – This study develops a novel model that combines activity-based costing (ABC), CRM, fuzzy analytic hierarchy process (AHP), and technique for order preference by similarity to ideal solution (TOPSIS) methods to evaluate strategically customer profitability and prioritizing corporate accounts. This case study airline company has invested heavily in CRM over the past seven years on integrating multi-functional departments that touch customers. The airline operations management and marketing functions provide key inputs. Results of the hybrid model validate feasibility of the proposed model. Findings – The airline management makes use of the ranking results to optimize customer profitability by reconfiguring marketing programs, integrated schedule design, fleet assignment, maintenance routing, crew scheduling, and real-time optimization of schedule recovery in the aftermath of disruptions or irregularities. The proposed model also directs the marketing function to customize service offerings and introduce appropriate service levels to engage customers of different segments for the purpose of maximizing corporate profitability. Research limitations/implications – Significant amount of investment is necessary to design and implement the extensive CRM database and systems to assure customer data quality and availability so as to bear fruits in the proposed hybrid model. These data requirements can especially be a critical barrier for small to medium-sized companies. Practical implications – This hybrid model is able to capitalize on the benefits of the ABC, CRM, fuzzy AHP, and TOPSIS methods and offset their deficiencies. Most importantly, it can be applied to various industries without complex modification. Originality/value – This study represents the first move to adopt the fuzzy AHP and TOPSIS methods to analyze the ABC and CRM data inputs of an airline company. In mapping the profit-based ranking of corporate customers into the current market segments, the relative profitability of each market segment can be determined.
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Song, Fengfei y Guang J. Zhang. "Understanding and Improving the Scale Dependence of Trigger Functions for Convective Parameterization Using Cloud-Resolving Model Data". Journal of Climate 31, n.º 18 (septiembre de 2018): 7385–99. http://dx.doi.org/10.1175/jcli-d-17-0660.1.
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As the resolution of global climate model increases, whether trigger functions in current convective parameterization schemes still work remains unknown. In this study, the scale dependence of undilute and dilute dCAPE, Bechtold, and heated condensation framework (HCF) triggers is evaluated using the cloud-resolving model (CRM) data. It is found that all these trigger functions are scale dependent, especially for dCAPE-type triggers, with skill scores dropping from ~0.6 at the lower resolutions (128, 64, and 32 km) to only ~0.1 at 4 km. The average convection frequency decreases from 14.1% at 128 km to 2.3% at 4 km in the CRM data, but it increases rapidly in the dCAPE-type triggers and is almost unchanged in the Bechtold and HCF triggers across resolutions, all leading to large overpredictions at higher resolutions. In the dCAPE-type triggers, the increased frequency is due to the increased rate of dCAPE greater than the threshold (65 J kg−1 h−1) at higher resolutions. The box-and-whisker plots show that the main body of dCAPE in the correct prediction and overprediction can be separated from each other in most resolutions. Moreover, the underprediction is found to be corresponding to the decaying phase of convection. Hence, two modifications are proposed to improve the scale dependence of the undilute dCAPE trigger: 1) increasing the dCAPE threshold and 2) considering convection history, which checks whether there is convection prior to the current time. With these modifications, the skill at 16 km, 8 km, and 4 km can be increased from 0.50, 0.27, and 0.15 to 0.70, 0.61, and 0.53, respectively.
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Welda, Welda, Bagus Baskara Sukarma y Emmy Febriani Thalib. "Sistem Informasi Penjualan Dengan Fitur Customer Relationship Management (CRM) Pada Tria Salon Berbasis Web". Jurnal Sistem Informasi dan Komputer Terapan Indonesia (JSIKTI) 1, n.º 3 (31 de marzo de 2019): 165–74. http://dx.doi.org/10.33173/jsikti.31.
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Sales is a transaction carried out by two or more parties between one person to another with a valid payment that generates an income. One of the factors of success of sales is to maintain good relationships with customers, such as giving special promotions to Pelaggan so that customers will continue to come to buy products or services offered by a company.In this study found problems such as the difficulty of determining customer loyalty, the difficulty of determining the product that must be stocked a lot, the difficulty in recording transactions because of the possibility of missing or incorrect data due to Tria salon still recording data in the ledger. In addition, other problems that arise are the delivery of promotions that take more time due to having to send the same message one by one to the customer.The solution to solving this problem is to build a sales information system with web-based customer relationship management (CRM) features. Which later can help admin performance in managing customer data, managing product and service data and managing transaction data. In addition, it can help salon owners in managing customer reports and transaction reports and can provide promotions to all customers.From the results of blackbox testing that has been done, the results obtained are that the test is in accordance with the process that is run and produces an output that is in accordance with the system functions that have been defined.
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Ahmed, Bashar Shahir, Mohamed Larabi Ben Maâti y Mohammed Al-Sarem. "Predictive Data Mining Model for Electronic Customer Relationship Management Intelligence". International Journal of Business Intelligence Research 11, n.º 2 (julio de 2020): 1–10. http://dx.doi.org/10.4018/ijbir.2020070101.
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The rising adoption of e-CRM strategies in marketing and customer relationship management has necessitated to more needs especially where a specific customer segment is targeted and the services are personalized. This paper presents a distributed data mining model using access-control architecture in a bid to realize the needs for an online CRM that intends to deliver web content to a specific group of customers. This hybrid model utilizes the integration of the mobile agent and client server technologies that could easily be updated from the already existing web platforms. The model allows the management team to derive insights from the operations of the system since it focuses on e-personalization and web intelligence hence presenting a better approach for decision support among organizations. To achieve this, a software approach made of access-control functions, data mining algorithms, customer-profiling capability, dynamic web page creation, and a rule-based system is utilized.
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G. Inyang, Udoinyang, Okure O. Obot, Moses E. Ekpenyong y Aliu M. Bolanle. "Unsupervised Learning Framework for Customer Requisition and Behavioral Pattern Classification". Modern Applied Science 11, n.º 9 (30 de agosto de 2017): 151. http://dx.doi.org/10.5539/mas.v11n9p151.
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Maintaining healthy organization-customers relationship has positive influence on customers’ behavioral tendencies as regards preference to products and services, buying behavior, loyalty, satisfaction, and so on. To achieve this, an in-depth analysis of customers’ characteristics and purchasing behavioral trend is required. This paper proposes a hybrid unsupervised learning framework consisting of k-means algorithm and self-organizing maps (SOMs) for customer segmentation and behavior analysis. K-means algorithm was used to partition the entire input space of customers’ transaction dataset into 3 and 4 disjoint segments based on customers’ frequency (F) and monetary value (MV). SOM provided visualization of the underlying clusters and discovered customers’ relationships in the dataset. Interaction of F and MV clusters resulted in 12 sub-clusters. An in-depth analysis of each sub-cluster was also performed and appropriate customer relationship management (CRM) strategies established for each sub-cluster. Discovered knowledge will guide effective allocation of resources to each customer cluster and other organizational decision support functions much required by CRM systems.
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Mert, Ufuk, Alshaimaa Adawy, Elisabeth Scharff, Pierre Teichmann, Anna Willms, Verena Haselmann, Cynthia Colmorgen et al. "TRAIL Induces Nuclear Translocation and Chromatin Localization of TRAIL Death Receptors". Cancers 11, n.º 8 (14 de agosto de 2019): 1167. http://dx.doi.org/10.3390/cancers11081167.
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Binding of tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) to the plasma membrane TRAIL-R1/-R2 selectively kills tumor cells. This discovery led to evaluation of TRAIL-R1/-R2 as targets for anti-cancer therapy, yet the corresponding clinical trials were disappointing. Meanwhile, it emerged that many cancer cells are TRAIL-resistant and that TRAIL-R1/-R2-triggering may lead to tumor-promoting effects. Intriguingly, recent studies uncovered specific functions of long ignored intracellular TRAIL-R1/-R2, with tumor-promoting functions of nuclear (n)TRAIL-R2 as the regulator of let-7-maturation. As nuclear trafficking of TRAIL-Rs is not well understood, we addressed this issue in our present study. Cell surface biotinylation and tracking of biotinylated proteins in intracellular compartments revealed that nTRAIL-Rs originate from the plasma membrane. Nuclear TRAIL-Rs-trafficking is a fast process, requiring clathrin-dependent endocytosis and it is TRAIL-dependent. Immunoprecipitation and immunofluorescence approaches revealed an interaction of nTRAIL-R2 with the nucleo-cytoplasmic shuttle protein Exportin-1/CRM-1. Mutation of a putative nuclear export sequence (NES) in TRAIL-R2 or the inhibition of CRM-1 by Leptomycin-B resulted in the nuclear accumulation of TRAIL-R2. In addition, TRAIL-R1 and TRAIL-R2 constitutively localize to chromatin, which is strongly enhanced by TRAIL-treatment. Our data highlight the novel role for surface-activated TRAIL-Rs by direct trafficking and signaling into the nucleus, a previously unknown signaling principle for cell surface receptors that belong to the TNF-superfamily.
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McIntosh, Richard J. "The H and K Family of Mock Theta Functions". Canadian Journal of Mathematics 64, n.º 4 (1 de agosto de 2012): 935–60. http://dx.doi.org/10.4153/cjm-2011-066-0.
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AbstractIn his last letter to Hardy, Ramanujan defined 17 functionsF(q), |q| < 1, which he calledmockθ-functions. He observed that asqradially approaches any root of unity ζ at whichF(q) has an exponential singularity, there is aθ-functionTζ(q) withF(q) −Tζ(q) =O(1). Since then, other functions have been found that possess this property. These functions are related to a functionH(x,q), wherexis usuallyqrore2πirfor some rational numberr. For this reason we refer toHas a “universal” mockθ-function. Modular transformations ofHgive rise to the functionsK,K1,K2. The functionsKandK1appear in Ramanujan's lost notebook. We prove various linear relations between these functions using Appell–Lerch sums (also called generalized Lambert series). Some relations (mock theta “conjectures”) involving mockθ-functions of even order andHare listed.
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Lischka, Peter, Claudia Rauh, Regina Mueller y Thomas Stamminger. "Human Cytomegalovirus UL84 Protein Contains Two Nuclear Export Signals and Shuttles between the Nucleus and the Cytoplasm". Journal of Virology 80, n.º 20 (15 de octubre de 2006): 10274–80. http://dx.doi.org/10.1128/jvi.00995-06.
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ABSTRACT Previous studies defined pUL84 of human cytomegalovirus as an essential regulatory protein with nuclear localization that was proposed to act during initiation of viral-DNA synthesis. Recently, we demonstrated that a complex domain of 282 amino acids within pUL84 functions as a nonconventional nuclear localization signal. Sequence inspection of this domain revealed the presence of motifs with homology to leucine-rich nuclear export signals. Here, we report the identification of two functional, autonomous nuclear export signals and show that pUL84 acts as a CRM-1-dependent nucleocytoplasmic shuttling protein. This suggests an unexpected cytoplasmic role for this essential viral regulatory protein.
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Azmi, Izwan, Norlida Abdul Hamid, Md Nasarudin Md Hussin y Nik Ibtishamiah Ibrahim. "Logistics and supply chain management: The importance of integration for business processes". Journal of Emerging Economies and Islamic Research 5, n.º 4 (31 de diciembre de 2017): 73. http://dx.doi.org/10.24191/jeeir.v5i4.8838.
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This conceptual paper outlines the importance of integration in supply chain management (SCM) by linking the functions of logistics as it applies in strategic business process. Often, business processes are developed at the strategic level but are never identified precisely in logistics or in SCM. Strategic business processes like Customer Relationship Management (CRM), Supplier Relationship Management (SRM), Customer Service Management (CSM) and Demand Management are not directly linked to logistics or SCM. This paper identifies the literature that expressed the importance of integration and how business processes can be relevant in the execution of key logistics activities in the supply chain context.
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Vasileva, A. V., N. N. Kalmykov, S. A. Melnikov y V. V. Solovyev. "Correlated signal model for a velocity simulator of a correlation radar meter". Journal of «Almaz – Antey» Air and Space Defence Corporation, n.º 4 (30 de diciembre de 2016): 18–23. http://dx.doi.org/10.38013/2542-0542-2016-4-18-23.
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One of the functions of a correlation radar meter for measuring altitude and velocity vector components is measuring the velocity vector components based on comparing correlation properties of the signals received by spatially separated antennae. The CRM test and control equipment contains a simplified velocity simulator forming signal transport delays according to the values of axial and transverse velocity vector components. We consider a correlated signal model allowing us to imitate a reflected signal that makes it possible to measure parameter values by means of transport delays and the difference in cross-correlation function maximum values.
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Sartoros, Christine, Douglas M. Goltz y Eric D. Salin. "Program Considerations for Simplex Optimization of Ion Lenses in ICP-MS". Applied Spectroscopy 52, n.º 5 (mayo de 1998): 643–48. http://dx.doi.org/10.1366/0003702981944292.
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The performance of an inductively coupled plasma mass spectrometer (ICP-MS) is dependent on the ion optic bias potentials. A discussion of the multielement optimization of the ICP-MS ion optics bias potentials using a Simplex algorithm is presented. Three objective functions were tested: a function developed by Leary; the combined ratio method (CRM); and the Euclidean distance from multicriteria target vector optimization. Both the Leary and the target vector optimization's performances were comparable, whereas the CRM optimizations placed an emphasis on obtaining similar signal intensities. Experiments determined that an initial Simplex starting size of 20% of the parameter space was optimal. A method for the selection of an appropriate target vector by predicting analyte signal intensity was also investigated. Signal intensities for all elements could be predicted with an acceptable margin of error (10–30%), provided that the same conditions were used. Comparisons of optimizations using a single mid-mass element vs. multielement optimizations revealed that the multielement approach is only slightly better. If the analyst wished to optimize lens settings to favor heavy or light elements, then an average mass was better than a mid-mass optimization.
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Lee, Kwanuk y Hunseung Kang. "Roles of Organellar RNA-Binding Proteins in Plant Growth, Development, and Abiotic Stress Responses". International Journal of Molecular Sciences 21, n.º 12 (26 de junio de 2020): 4548. http://dx.doi.org/10.3390/ijms21124548.
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Organellar gene expression (OGE) in chloroplasts and mitochondria is primarily modulated at post-transcriptional levels, including RNA processing, intron splicing, RNA stability, editing, and translational control. Nucleus-encoded Chloroplast or Mitochondrial RNA-Binding Proteins (nCMRBPs) are key regulatory factors that are crucial for the fine-tuned regulation of post-transcriptional RNA metabolism in organelles. Although the functional roles of nCMRBPs have been studied in plants, their cellular and physiological functions remain largely unknown. Nevertheless, existing studies that have characterized the functions of nCMRBP families, such as chloroplast ribosome maturation and splicing domain (CRM) proteins, pentatricopeptide repeat (PPR) proteins, DEAD-Box RNA helicase (DBRH) proteins, and S1-domain containing proteins (SDPs), have begun to shed light on the role of nCMRBPs in plant growth, development, and stress responses. Here, we review the latest research developments regarding the functional roles of organellar RBPs in RNA metabolism during growth, development, and abiotic stress responses in plants.
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Lawrence, Kenneth D., Dinesh R. Pai, Ronald Klimberg y Sheila M. Lawrence. "Enterprise Information System and Data Mining". International Journal of Business Intelligence Research 1, n.º 3 (julio de 2010): 34–41. http://dx.doi.org/10.4018/jbir.2010070103.
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The advent of information technology and the consequent proliferation of information systems have lead to generation of vast amounts of data, both within the organization and across its supply chain. Enterprise information systems (EIS) have added to organizational complexity, and at the same time, created opportunities for enhancing its competitive advantage by utilizing this data for business intelligence purposes. Various data mining tools have been used to gain a competitive edge through these large data bases. In this paper, the authors discuss EIS-aided business intelligence and data mining as applicable to organizational functions, such as supply chain management (SCM), marketing, and customer relationship management (CRM) in the context of EIS.
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Amalnik, Morteza Sadegh. "A Reference Model and a vision for manufacturing system for 2030". INTERNATIONAL JOURNAL OF COMPUTERS & TECHNOLOGY 14, n.º 7 (30 de abril de 2015): 5861–68. http://dx.doi.org/10.24297/ijct.v14i7.1899.
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The manufacturing enterprises are now experiencing high pressure of competition. In addition, the advancement in computer software, hardware, networks, information technologies and integration has been gradually reshaping the manufacturing companies by shifting from the industrial age to the information and knowledge era. Due to these elevated competitiveness and advanced computer technology, a number of new manufacturing and management strategies (e.g., Lean production, Just in time, Kaizen, Concurrent Engineering (CE), Cellular Manufacturing (CM), Agile manufacturing, Business process re-engineering (BPR), Agent-based systems (ABS), Computer Integrated Manufacturing (CIM), virtual manufacturing system have emerged for the innovation of manufacturing industries. The developments in organizational concepts created new concepts such as Smart organizations, Centers of excellence, Intelligent enterprises, Integrated enterprises, Virtual enterprises, Virtual enterprises networks, Dynamic enterprises, Extended enterprises, Agile enterprises, Lean enterprises, Process-driven organizations, e-enterprises, Borderless enterprises, Complicated or complex manufacturing systems, Flat structures and others. These terms have been used by researchers to describe various aspects of enterprises and its operational aspects. Although they have different definitions and scopes, there are several common issues: integration of enterprise functions; integration of enterprise resources; and collaboration. In addition Various vendors produced software applications such as Materials Requirement Planning (MRP), Manufacturing Resource Planning (MRP II), Enterprise Resource Planning (ERP),CAD/CAM systems, Manufacturing Execution System (MES), Advanced Planning & Scheduling System (APS), Supply Chain Execution (SCE), Customer Relationship Management (CRM), Advanced Order Management (AOM), Warehouse Management Systems (WMS), Transport Management System (TMS) and others. This paper proposes a Reference Model and vision for Manufacturing System for 2030 and discussed various aspects of future manufacturing enterprise..It supports the inter-enterprise functions/resources integration and collaboration over the networked environment.
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Isern, Germinal y Giuseppe Sena. "Technical, Organizational and Cross-cultural issues associated with the deployment of Customer Relationship Management (CRM) in Transnational and Global Multicultural Organizations". Journal of Intercultural Management 6, n.º 3 (1 de septiembre de 2015): 187–96. http://dx.doi.org/10.2478/joim-2014-0029.
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Abstract In the past few years the way in which, organizations, companies and corporations structure themselves has given a 180 degrees turnaround, switching from a structure based in products to a structure based in customers. The first big change was the introduction and use of Enterprise Resource Planning Systems (ERP) like SAP and Oracle. Those ERP systems changed the way in which the information was managed in large corporations including now a central database and visualizing the structures and functions of the corporation by business processes and not by business areas. Also lately with the advent of the WEB 2.0, the boom of the social media and the big data analytics areas, business, marketing and the relation with the customer has totally changed. One of the most important drivers for this turnaround is the adoption of Customer Relationship Management (CRM). CRM is supporting software designed to improve the relation with the current customers (loyalty) using modern social media and massive marketing technologies. This paper introduces the organizational issues of cross-cultural communication associated with the integration between marketing, customer service, and complaint management with information technology. In highly competitive environments a lot of organizations intent to construct a relationship with their current customers, since the cost involved in capturing new ones is a lot higher than the cost of retaining the current ones. The most crucial factor is the understanding of the clients and their values, norms, traditions, language, religions, perceptions, thoughts in few words their culture. So this cultural dimension analysis is essential and the development of a formal taxonomy or cultural concern framework a need. This paper will deal with the dimension concerns from the technical, cultural and organizational point of view needed to build this framework in order to avoid the terrible consequences of a wrong interaction with the customers due to cultural issues.
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Tang, Y., J. J. Jing, Y. Yang y C. Xie. "Parameter Estimation of a Delay Time Model of Wearing Parts Based on Objective Data". Mathematical Problems in Engineering 2015 (2015): 1–8. http://dx.doi.org/10.1155/2015/419280.
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The wearing parts of a system have a very high failure frequency, making it necessary to carry out continual functional inspections and maintenance to protect the system from unscheduled downtime. This allows for the collection of a large amount of maintenance data. Taking the unique characteristics of the wearing parts into consideration, we establish their respective delay time models in ideal inspection cases and nonideal inspection cases. The model parameters are estimated entirely using the collected maintenance data. Then, a likelihood function of all renewal events is derived based on their occurring probability functions, and the model parameters are calculated with the maximum likelihood function method, which is solved by the CRM. Finally, using two wearing parts from the oil and gas drilling industry as examples—the filter element and the blowout preventer rubber core—the parameters of the distribution function of the initial failure time and the delay time for each example are estimated, and their distribution functions are obtained. Such parameter estimation based on objective data will contribute to the optimization of the reasonable function inspection interval and will also provide some theoretical models to support the integrity management of equipment or systems.
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Prüfer, Kirsten y Julia Barsony. "Retinoid X Receptor Dominates the Nuclear Import and Export of the Unliganded Vitamin D Receptor". Molecular Endocrinology 16, n.º 8 (1 de agosto de 2002): 1738–51. http://dx.doi.org/10.1210/me.2001-0345.
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Abstract Liganded and unliganded vitamin D receptors (VDRs) carry out distinct functions; both types of functions require heterodimerization with retinoid X receptors (RXRs). Our recent studies with fluorescent protein chimeras of VDR and RXR, termed GFP-VDR, YFP-RXR, and RXR-BFP, indicated that RXR regulates VDR functions in part by regulating subcellular localization. Here we explored the mechanisms of this regulation. Photobleaching experiments demonstrated that YFP-RXR and both unliganded and liganded GFP-VDR shuttle constantly between nucleus and cytoplasm. To characterize RXR import, we identified a nuclear localization sequence (NLS) in the DNA-binding domain. Mutations in this NLS caused predominant cytoplasmic localization of nlsYFP-RXR and prevented transcriptional activity. The nlsRXR-BFP retained unliganded GFP-VDR in the cytoplasm and reduced baseline transcriptional activity. After calcitriol exposure, however, both GFP-VDR and nlsRXR-BFP entered the nucleus. We characterized receptor export rates and mechanisms using permeabilization experiments. Mutations in the calreticulin binding region slowed both GFP-VDR and YFP-RXR export. Coexpression of RXR-BFP slowed the export of unliganded GFP-VDR, whereas calcitriol treatment tripled the rate of GFP-VDR export. Treatment with leptomycin B, an inhibitor of CRM-1 receptor-mediated export, inhibited export of unliganded GFP-VDR but did not influence export of liganded GFP-VDR or YFP-RXR. Leptomycin B added before calcitriol similarly decreased hormone-induced luciferase activity but was ineffective when added subsequent to calcitriol. These results indicate that the unliganded and liganded VDR interact differently with the import and export receptors and with RXR. Most likely, the regulation of VDR nuclear import by RXR is essential for ligand-independent functions.
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Wodrich, Harald, Jens Bohne, Ellen Gumz, Reinhold Welker y Hans-Georg Kräusslich. "A New RNA Element Located in the Coding Region of a Murine Endogenous Retrovirus Can Functionally Replace the Rev/Rev-Responsive Element System in Human Immunodeficiency Virus Type 1 Gag Expression". Journal of Virology 75, n.º 22 (15 de noviembre de 2001): 10670–82. http://dx.doi.org/10.1128/jvi.75.22.10670-10682.2001.
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ABSTRACT Nuclear export of incompletely spliced RNAs is a prerequisite for retroviral replication. Complex retroviruses like human immunodeficiency virus (HIV) encode a viral transport factor (Rev), which binds to its target sequence on the RNA genome and directs it into the Crm-1-mediated export pathway. Other retroviruses, like Mason-Pfizer monkey virus, contain cis-acting constitutive RNA transport elements (CTE) which achieve nuclear export of intron-containing RNA via cellular transport factors. Here, we describe the identification and characterization of a novelcis-acting orientation-dependent RNA expression element in the coding region of the murine intracisternal A-type particle (IAP) MIA14. This IAP expression element (IAPE) can functionally replace the Rev system in the expression of HIV-1 Gag proteins but functions independently of Crm-1. The presence of this element is needed for the expression of the IAP Gag proteins, indicating its biological significance. The IAPE can be functionally replaced by placing a CTE on the MIA14 RNA, further supporting its role in mRNA export. Northern blot analysis revealed that total RNA, as well as cytoplasmic RNA, was increased when the element was present. The element was mapped to a predicted stem-loop structure in the 3′ part of the polopen reading frame. There was no overall homology between the IAPE and the CTE, but there was complete sequence identity between short putative single-stranded loops. Deletion of these loops from the IAPE severely reduced Rev-independent Gag expression.
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Saunders, Rebecca, Nuha Shiltagh, Keith Gomez, Gillian Mellars, Carolyn Cooper, David Perry, Edward Tuddenham y Stephen Perkins. "Structural analysis of eight novel and 112 previously reported missense mutations in the interactive FXI mutation database reveals new insight on FXI deficiency". Thrombosis and Haemostasis 102, n.º 08 (2009): 287–301. http://dx.doi.org/10.1160/th09-01-0044.
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SummaryFactor XI (FXI) functions in blood coagulation. FXI is composed of four apple (Ap) domains and a serine protease (SP) domain. Deficiency of FXI leads to an injury-related bleeding disorder, which is remarkable for the lack of correlation between bleeding symptoms and FXI coagulant activity (FXI:C).The number of mutations previously reported in our interactive web database (http://www.FactorXI.org) is now significantly increased to 183 through our new patient studies and from literature surveys. Eight novel missense mutations give a total of 120 throughout the FXI gene (F11).The most abundant defects in FXI are revealed to be those from low-protein plasma levels (Type I: CRM-) that originate from protein misfolding, rather than from functional defects (Type II: CRM+). A total of 70 Ap missense mutations were analysed using a consensus Ap domain structure generated from the FXI dimer crystal structure. This showed that all parts of the Ap domain were affected.The 47 SP missense mutations were also distributed throughout the SP domain structure.The periphery of the Ap β-sheet structure is sensitive to structural perturbation caused by residue changes throughout the Ap domain, yet this β-sheet is crucial for FXI dimer formation. Residues located at the Ap4:Ap4 interface in the dimer are much less directly involved. We conclude that the abundance of Type I defects in FXI results from the sensitivity of the Ap domain folding to residue changes within this, and discuss how structural knowledge of the mutations improves our understanding of FXI deficiencies.
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Carboni y Luca. "An Ontological Approach to the Description of Visual and Iconographical Representations". Heritage 2, n.º 2 (20 de abril de 2019): 1191–210. http://dx.doi.org/10.3390/heritage2020078.
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The perception of our heritage is based on sign-functions, which relate visual representations to cognitive types, allowing us to make perceptual judgements over physical objects. The recording of these types of assertions is paramount for the comprehension and analysis of our heritage. The article investigates a theoretical framework for the organization of information related to visual works on the basis of the identity and symbolic value of their single constituent elements. The framework developed is then used as a driver for the grounding of a new ontology called VIR (Visual Representation), constructed as an extension of CIDOC-CRM (CIDOC Conceptual Reference Model). VIR sustains the recording of statements about the different structural units and relationships of a visual representation, differentiating between object and interpretative act. The result, tested with data describing Byzantine and Renaissance artworks, presents solutions for describing symbols and meanings of iconographical objects, providing new clustering methods in relation to their constitutive elements, subjects or interpretations.
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Chen, Jingfei, Jialei Duan, Alina Montalbano, Boxun Li, Gary Hon y Carole R. Mendelson. "Single-Cell RNA-Seq of Mouse Decidual Leukocytes Reveals Intriguing Gestational Changes in the Immune Cell Landscape and Effects of SRC-1/-2 Double-Deficiency". Journal of the Endocrine Society 5, Supplement_1 (1 de mayo de 2021): A753—A754. http://dx.doi.org/10.1210/jendso/bvab048.1532.
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Abstract Single-cell RNA-seq of Mouse Decidual Leukocytes Reveals Intriguing Gestational Changes in the Immune Cell Landscape and Effects of SRC-1/-2 Double-DeficiencyOur previous findings suggest that the fetus signals the mother when it is ready to be born through secretion of surfactant components/immune modulators, surfactant protein A (SP-A) and platelet-activating factor (PAF) by the fetal lung into amniotic fluid (AF). This occurs with increased proinflammatory cytokine expression by fetal AF macrophages (Mϕ), increased myometrial NF-κB activation and contractile (CAP) gene expression. Steroid receptor coactivator (Src)-1 and Src-2 are critical for developmental induction SP-A and PAF by the fetal lung. The finding that pregnant wild-type (WT) mice carrying Src-1 and Src-2 double-deficient fetuses (Src-1/-2d/d) manifested a marked delay (~38h) in parturition, further suggests that signals for parturition arise from the fetus and that Src-1 and Src-2 serve a critical role. Infiltrating leukocytes at the maternal-fetal interface (MFI)/decidua are known to play a central role in pregnancy maintenance and parturition timing. However, there is limited knowledge regarding gestational changes in immune cell composition toward term. To analyze gestational changes in the composition of immune cells within decidua and effects of Src-1/-2d/d, we conducted single-cell RNA-seq of ~17,000 decidual leukocytes (CD45+) from pregnant mice at 15.5 and 18.5 dpc carrying WT or Src-1/-2d/d fetuses. Unsupervised clustering identified 22 distinct decidual immune cell clusters, comprised of Mϕ, B cells, natural killer cells, neutrophils, dendritic cells and monocytes. Significant differences in cell type composition and transcriptional profiles were found across study groups (WT @ 15.5 dpc vs. 18.5 dpc; Src-1/-2d/dvs. WT @15.5 dpc and 18.5 dpc). Interestingly, in deciduas of pregnant mice carrying WT fetuses, Mϕ and B cell clusters markedly increased between 15.5 and 18.5 dpc, whereas, neutrophils declined; however, these gestational changes did not occur in pregnant mice carrying Src-1/-2d/d fetuses. Differential gene expression and gene ontology enrichment analyses revealed specific gene expression patterns distinguishing these immune cell subtypes to uncover their putative functions. These findings highlight the complexity and dynamics of the decidual immune cell landscape during the transition from myometrial quiescence to contractility, and the fetal-maternal interactions leading to parturition. Support: NIH grants R01-HL050022 (CRM) and P01-HD087150 (CRM), Burroughs Wellcome Preterm Birth Grant #1019823 (CRM).
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Jeong, Sinwoo, Soobum Lee y Honghee Yoo. "Design Scalability Study of the Γ-Shaped Piezoelectric Harvester Based on Generalized Classical Ritz Method and Optimization". Electronics 10, n.º 16 (6 de agosto de 2021): 1887. http://dx.doi.org/10.3390/electronics10161887.
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This paper studies the design scalability of a Γ-shaped piezoelectric energy harvester (ΓEH) using the generalized classical Ritz method (GCRM) and differential evolution algorithm. The generalized classical Ritz method (GCRM) is the advanced version of the classical Ritz method (CRM) that can handle a multibody system by assembling its equations of motion interconnected by the constraint equations. In this study, the GCRM is extended for analysis of the piezoelectric energy harvesters with material and/or orientation discontinuity between members. The electromechanical equations of motion are derived for the PE harvester using GCRM, and the accuracy of the numerical simulation is experimentally validated by comparing frequency response functions for voltage and power output. Then the GCRM is used in the power maximization design study that considers four different total masses—15 g, 30 g, 45 g, 60 g—to understand design scalability. The optimized ΓEH has the maximum normalized power density of 23.1 × 103 kg·s·m−3 which is the highest among the reviewed PE harvesters. We discuss how the design parameters need to be determined at different harvester scales.
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Diniz, Márcio A., Sungjin Kim y Mourad Tighiouart. "A Bayesian Adaptive Design in Cancer Phase I Trials Using Dose Combinations with Ordinal Toxicity Grades". Stats 3, n.º 3 (17 de julio de 2020): 221–38. http://dx.doi.org/10.3390/stats3030017.
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We propose a Bayesian adaptive design for early phase drug combination cancer trials incorporating ordinal grade of toxicities. Parametric models are used to describe the relationship between the dose combinations and the probabilities of the ordinal toxicities under the proportional odds assumption. Trial design proceeds by treating cohorts of two patients simultaneously receiving different dose combinations. Specifically, at each stage of the trial, we seek the dose of one agent by minimizing the Bayes risk with respect to a loss function given the current dose of the other agent. We consider two types of loss functions corresponding to the Continual Reassessment Method (CRM) and Escalation with Overdose Control (EWOC). At the end of the trial, we estimate the MTD curve as a function of Bayes estimates of the model parameters. We evaluate design operating characteristics in terms of safety of the trial and percent of dose recommendation at dose combination neighborhoods around the true MTD by comparing this design to the one that uses a binary indicator of DLT. The methodology is further adapted to the case of a pre-specified discrete set of dose combinations.