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Artículos de revistas sobre el tema "Cultic acts"

Autor: Grafiati

Publicado: 4 de junio de 2021

Última modificación: 29 de julio de 2025

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1

Rizun, Nazar. "SCANDINAVIAN THING-ASSEMBLIES AND CULTIC SITES AS RITUAL SPACE: RESEARCH STATUS." Ethnic History of European Nations, no. 64 (2021): 7–14. http://dx.doi.org/10.17721/2518-1270.2021.64.01.

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The article investigates the most recent studies on ritual space (thing-assemblies, cultic sites, and ceremonial buildings) in the late Iron Age and medieval Scandinavia. Various rituals, performed at these locations, allowed elites and rulers to gain and maintain power, to create and sustain social order, to resolve conflicts. The paper explores the works of A. Sanmark (research on assemblies as ritual space), F. Iversen (centers of cult), O. Sundqvist (cultic sites and buildings), L. Sonne (political leaders and cult), L. Larsson (ceremonial structures), and other contemporary scholars. The

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2

Proctor, Travis W. "Hospitality, not Honors: Portraits and Patronage in the Acts of John." Harvard Theological Review 115, no. 1 (2022): 69–89. http://dx.doi.org/10.1017/s0017816022000050.

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AbstractIn this article, I examine how the apocryphal Acts of John depicts wealthy Christian converts as part of the “Christianization” of Ephesus. I note how the Acts of John uses its portrayal of leading citizens not only to critique, but to preserve and adapt prevailing expectations surrounding Greco-Roman cultic patronage. My analysis comprises two parts. In the first part, I discuss the ways in which the Acts of John undermines prevalent Greco-Roman practices of benefaction. I note that the Acts of John criticizes monetary offerings as part of cultic “exchanges,” and thus indirectly conde

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3

DeGrado, Jessie. "The qdesha in Hosea 4:14: Putting the (Myth of the) Sacred Prostitute to Bed." Vetus Testamentum 68, no. 1 (2018): 8–40. http://dx.doi.org/10.1163/15685330-12341300.

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AbstractDespite a lack of evidence for the practice of sacred prostitution in the ancient Middle East, scholars have continued to understand the wordqdešɔin Hosea 4:14 to denote a female officiant who performed sexual acts in a cultic setting. This article argues that the understanding of theqdešɔas a cultic prostitute has appealed to interpreters for over two millennia because the Hebrew word has a semantic range that includes both female cultic functionaries and prostitutes. The lexeme denotes a class of women who are employed outside of the patrimonial estate, including priestesses or prost

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4

Akagi, Kai. "Acceptability and Purity in Acts 10:35." Novum Testamentum 66, no. 3 (2024): 309–20. http://dx.doi.org/10.1163/15685365-bja10075.

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Abstract δεκτός in Acts 10:35 may be understood as a term from the Jewish purity and consecration system. With a high degree of consistency, Hebrew רצון and רצה are rendered in cultic contexts in the LXX with words of the δεκ- lexeme. While verbs of the δεκ- lexeme are not uncommon prior to the LXX, adjectives of the δεκ-lexeme are uncommon outside of the LXX prior to the NT, establishing the use of δεκ- adjectives in the LXX as the primary context for δεκτός in Acts. This interpretation is consistent with themes of purity and consecration in the Cornelius episode and throughout Luke-Acts.

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5

Proctor, Travis. "Environmental Change, the Acts of John, and Shifting Cultic Landscapes in Late Antique Ephesus." Studies in Late Antiquity 5, no. 2 (2021): 176–215. http://dx.doi.org/10.1525/sla.2021.5.2.176.

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The city of Ephesus experienced a marked civic transformation in Late Antiquity. After having centered its settlements and economic fortunes on its proximity to a deep-water harbor for over a millenium, late antique Ephesus gradually shifted to an inland, fortified settlement on Ayasoluk Hill. While several factors undoubtedly informed this civic reorientation, the most commonly cited impetus for Ephesus’s late antique reorientation was the infilling of its deep-water harbor. This article argues that, in addition to this environmental cause, an important cultural shift correspondingly informed

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6

Harland, Philip A. "Honours and worship: Emperors, imperial cults and associations at Ephesus (first to third centuries C.E.)." Studies in Religion/Sciences Religieuses 25, no. 3 (1996): 319–34. http://dx.doi.org/10.1177/000842989602500306.

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Scholars have frequently underplayed the significance of the emperors within actual social and religious life in cities of the Roman empire and have portrayed imperial cults as predominantly political, lacking in religious dimensions. However, this view of imperial cults is misguided and acts as an obstacle to understanding the nature and significance of these cults at the local level. A fresh study of associations (local social-religious groups) in Ephesus helps to clarify the significance of emperors with respect to social, political and religious facets of life. There were two main intercon

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7

Fadeev, Andrew. "Integration of Mental Spaces on the Example of the Cultic Milieu's Concept "Bigfoot"." Proceedings of the Saratov Orthodox Theological Seminary, no. 1 (24) (May 24, 2024): 11–31. http://dx.doi.org/10.56621/27825884_2024_24_11.

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The aim of the study is to test the method of conceptual integration of mental spaces for the Cultic Milieu’s concept "bigfoot". The article focuses on the fact that the concept acts as a mental representation of the corresponding fragment of the surrounding reality as a dynamic structure of knowledge. A feature of the above example is cognitive fiction, which, nevertheless, has a stable vitality in the discourse of unconventional religiosity. The scientific novelty of the study is to identify the initial mental spaces, their integration and the isolation of new emergent properties that contri

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8

Shin, W. Gil. "Holy Land Sanctity for Every Greco-Roman City: Rethinking the Lukan Apostolic Decree (Acts 15:19–21)." Journal of Biblical Literature 141, no. 3 (2022): 553–74. http://dx.doi.org/10.15699/jbl.1413.2022.8.

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Abstract The meaning of the enigmatic verse of Acts 15:21, not to mention the issues around the preceding Apostolic Decree (vv. 19–20), has largely been researched individually and historical-critically. By contrast, in this study I explicate the meaning of the verse within the broader scope of James’s speech by attending to the Jewish spatiality on Luke’s narrative-ideological plane. The Lukan James’s speech tightly combines intertextual elements that bear on significant Jewish spatiality, namely, the restored tent of David (v. 16) within the quotation of Amos 9:11–12, the alluded-to holy lan

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9

Eubank, Nathan. "Justice Endures Forever: Paul's Grammar of Generosity." Journal for the Study of Paul and His Letters 5, no. 2 (2015): 169–87. http://dx.doi.org/10.2307/26371765.

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For centuries before and after Paul, Jewish sages taught that charitable deeds are among the supreme acts of fidelity to God. Paul himself taught what might be called a traditional Jewish theology of charitable giving. He describes generosity to humans as an act of service for God that will bring happy returns in the future. He uses the cultic and financial metaphors that are common in other Jewish discussions of charity, and he also quotes biblical texts that speak of God's protection of the generous. This article concludes by noting the implications of this largely unrecognized point of cont

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Eubank, Nathan. "Justice Endures Forever: Paul's Grammar of Generosity." Journal for the Study of Paul and His Letters 5, no. 2 (2015): 169–87. http://dx.doi.org/10.2307/jstudpaullett.5.2.0169.

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For centuries before and after Paul, Jewish sages taught that charitable deeds are among the supreme acts of fidelity to God. Paul himself taught what might be called a traditional Jewish theology of charitable giving. He describes generosity to humans as an act of service for God that will bring happy returns in the future. He uses the cultic and financial metaphors that are common in other Jewish discussions of charity, and he also quotes biblical texts that speak of God's protection of the generous. This article concludes by noting the implications of this largely unrecognized point of cont

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11

Dietrich, Oliver. "Learning from ‘Scrap’ about Late Bronze Age Hoarding Practices: A Biographical Approach to Individual Acts of Dedication in Large Metal Hoards of the Carpathian Basin." European Journal of Archaeology 17, no. 3 (2014): 468–86. http://dx.doi.org/10.1179/1461957114y.0000000061.

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Hoard finds appear throughout the European Bronze Age with distinct chronological and chorological peaks. While there is some consensus on seeing hoards as an expression of cultic behaviour, the large ‘scrap metal' hoards in particular still provoke interpretations as raw material collected for recycling. With socketed axes whose sockets were intentionally filled with deliberately fragmented metalwork, Hansen (1996–1998) has pointed out a group of finds that could be crucial to a better understanding of ‘scrap’ hoards. Using the finds from the Carpathian Basin as a case study, a dual biographi

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12

Chilton, Paul, and Monika Kopytowska. "Political dialogue across time, space and genres." International Review of Pragmatics 14, no. 2 (2022): 226–51. http://dx.doi.org/10.1163/18773109-01402004.

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Abstract The objective behind this paper is to outline an integrated cognitive-social-pragmatic approach to the re-emergence of far-right cultic politics along with the role of social media in enhancing the dialogic impact of contemporary discourses of hostility. We start from the assumption that while deixis and speech acts enable attribution of status functions and deontic powers, and thus legitimation on the level of discourse (which is key in construction of the self vis-à-vis others), cyberspace, with the semiotic affordances it offers, creates a conducive environment for expanding the di

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13

Glancy, Jennifer. "FAMILY PLOTS: BURYING SLAVES DEEP IN HISTORICAL GROUND." Biblical Interpretation 10, no. 1 (2002): 57–75. http://dx.doi.org/10.1163/156851502753443290.

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AbstractDespite the anthropological identification of slavery as an anti-kinship structure, some New Testament scholars have attempted to "kin-ify" the relations between slaveholders and slaves, that is, to interpret slavery as a fictive kinship structure. Commentators on Acts of the Apostles, for example, are likely to accept the patriarchal or matriarchal right of householders to enforce decisions concerning the cultic practices of household slaves. By suggesting that the Spirit responds to the invitations of slaveholders, household by patriarchal household, Acts treats enslaved members of h

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14

Biddle, Mark E. "The (re-)establishment of order: Disorder in the priestly understanding and in the teaching and acts of Jesus." Review & Expositor 114, no. 2 (2017): 166–75. http://dx.doi.org/10.1177/0034637317702098.

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While a biblical doctrine of sin requires the honest and careful assessment of the complexity and plurality of the biblical witness,2 especially with regard to the relationship of the two Testaments, scholarship often draws lines of demarcation between the two Testaments too sharply. Ancient Israel’s priests devoted significant attention to the “objective” quality of wrong done as a pastoral problem, for example. Leviticus establishes that “unintentional sin” covers the whole gamut of behaviors short of willful sin that can result in terrible injury and harm. Indeed, the priests so consistentl

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15

Mastrocinque, Attilio. "The Mithraic praesepia as Dining Beds." Acta Antiqua Academiae Scientiarum Hungaricae 58, no. 1-4 (2018): 421–26. http://dx.doi.org/10.1556/068.2018.58.1-4.25.

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Summary A mithraeum always has long benches, which were called praesepiae, “places where cattle are fed in a stall” (CIMRM 233). The name is inappropriate for a dining room, which was usually called, instead, triclinium. Mithraeum is the current modern name, whereas the ancients called it spelaeum, antrum, templum. Another important name was Leonteum, which was not a separate cultic place for Leones only, because Porphyry states that the members of a Mithraic community were the Leones and the servants were called Korakes, the Ravens (Porphyr. de abst. 4. 16). The Mithraic menu apparently consi

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16

Grassi, Umberto. "Acts or Identities? Rethinking Foucault on Homosexuality." Cultural History 5, no. 2 (2016): 200–221. http://dx.doi.org/10.3366/cult.2016.0126.

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In the first part of this article I summarize the ongoing historiographical debate over Michel Foucault's theory of the nineteenth-century medical ‘invention’ of homosexuality, as it was formulated in the 1976 first volume of The History of Sexuality, The Will to Knowledge. Starting from the now-outdated conflict between ‘essentialists’ and ‘social constructionists’, I underline the ‘blind spots’ of the Foucauldian narrative as highlighted by postcolonial, feminist and queer criticisms. In the second part, I shift to the historiography of the early modern Iberian and Colonial world. Even thoug

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Precious, B., K. Childs, V. Fitzpatrick-Swallow, S. Goodbourn, and R. E. Randall. "Simian Virus 5 V Protein Acts as an Adaptor, Linking DDB1 to STAT2, To Facilitate the Ubiquitination of STAT1." Journal of Virology 79, no. 21 (2005): 13434–41. http://dx.doi.org/10.1128/jvi.79.21.13434-13441.2005.

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ABSTRACT The V protein of simian virus 5 (SV5) facilitates the ubiquitination and subsequent proteasome-mediated degradation of STAT1. Here we show, by visualizing direct protein-protein interactions and by using the yeast two-hybrid system, that while the SV5 V protein fails to bind to STAT1 directly, it binds directly and independently to both DDB1 and STAT2, two cellular proteins known to be essential for SV5-mediated degradation of STAT1. We also demonstrate that STAT1 and STAT2 interact independently of SV5 V and show that SV5 V protein acts as an adaptor molecule linking DDB1 to STAT2/ST

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18

Bondarchuk, Yaroslava. "Display of the Ancient Religious Bone Cults in the Late Acheulean–Mousterian Art." NaUKMA Research Papers. History and Theory of Culture 4 (June 15, 2021): 35–45. http://dx.doi.org/10.18523/2617-8907.2021.4.35-45.

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The relevance of research. One of the most important unsolved problems of cultural studies, religious studies, art history, and history is to determine the time of the origin of religious ideas: that of the beginning of the spiritual evolution of the mankind, which at a certain stage of development begins to master not only the material world but also tries to comprehend the supernatural transcendent reality. The views of scholars regarding the time of the birth of religious beliefs is divided into two opposing points of view. According to one of them, expressed in the works of R. Marett, F. R

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19

Rambaud, Thierry. "Le budget des cultes. Actes de la Journée d'études du 30 janvier sur le budget des cultes." Church History and Religious Culture 88, no. 4 (2008): 644–45. http://dx.doi.org/10.1163/187124108x426862.

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20

Kim, Woohyun, Sooyoung Lee, Yeongnam Son, Chunkyu Ko, and Wang-Shick Ryu. "DDB1 Stimulates Viral Transcription of Hepatitis B Virus via HBx-Independent Mechanisms." Journal of Virology 90, no. 21 (2016): 9644–53. http://dx.doi.org/10.1128/jvi.00977-16.

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ABSTRACTHBx, a small regulatory protein of hepatitis B virus (HBV), augments viral DNA replication by stimulating viral transcription. Among numerous reported HBx-binding proteins, DDB1 has drawn attention, because DDB1 acts as a substrate receptor of the Cul4-DDB1 ubiquitin E3 ligase. Previous work reported that the DDB1-HBx interaction is indispensable for HBx-stimulated viral DNA replication, suggesting that the Cul4-DDB1 ubiquitin E3 ligase might target cellular restriction factors for ubiquitination and proteasomal degradation. To gain further insight into the DDB1-HBx interaction, we gen

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21

Panek, Johan, Spencer S. Gang, Kirthi C. Reddy, et al. "A cullin-RING ubiquitin ligase promotes thermotolerance as part of the intracellular pathogen response inCaenorhabditis elegans." Proceedings of the National Academy of Sciences 117, no. 14 (2020): 7950–60. http://dx.doi.org/10.1073/pnas.1918417117.

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Intracellular pathogen infection leads to proteotoxic stress in host organisms. Previously we described a physiological program in the nematodeCaenorhabditis eleganscalled the intracellular pathogen response (IPR), which promotes resistance to proteotoxic stress and appears to be distinct from canonical proteostasis pathways. The IPR is controlled by PALS-22 and PALS-25, proteins of unknown biochemical function, which regulate expression of genes induced by natural intracellular pathogens. We previously showed that PALS-22 and PALS-25 regulate the mRNA expression of the predicted ubiquitin lig

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22

Scherer, Paul C., Yan Ding, Zhiqing Liu, et al. "Inositol hexakisphosphate (IP6) generated by IP5K mediates cullin-COP9 signalosome interactions and CRL function." Proceedings of the National Academy of Sciences 113, no. 13 (2016): 3503–8. http://dx.doi.org/10.1073/pnas.1525580113.

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The family of cullin-RING E3 Ligases (CRLs) and the constitutive photomorphogenesis 9 (COP9) signalosome (CSN) form dynamic complexes that mediate ubiquitylation of 20% of the proteome, yet regulation of their assembly/disassembly remains poorly understood. Inositol polyphosphates are highly conserved signaling molecules implicated in diverse cellular processes. We now report that inositol hexakisphosphate (IP6) is a major physiologic determinant of the CRL–CSN interface, which includes a hitherto unidentified electrostatic interaction between the N-terminal acidic tail of CSN subunit 2 (CSN2)

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23

Finocchiaro, Francesco. "El matrimonio de los acatólicos en el Derecho italiano." Ius Canonicum 14, no. 27 (2018): 117–31. http://dx.doi.org/10.15581/016.14.21350.

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Post brevem introductionem de modo perveniendi ad actualem disciplinam acatholicorum matrimonii in lure italico, designatur triplex via matrimonialis italica: matrimonium canonicum transcriptum ad effectus civiles, matrimonium celebratum ante procuratorem registri civilis et matrimonium celebratum ante acatholicos ministros culti. Hoc ultimum suppositum, compartáis aliis duabus viis, est obiectum studii articuli. Quod matrimonium validum sit pendet ab eo quod nominatio ministri ab auctoritate religiosa approbata fuerit a Ministerio Gubernationis; non vero ab eo quod celebratum fuerit in ambitu

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Bigenzahn, Johannes W., Giovanna M. Collu, Felix Kartnig, et al. "LZTR1 is a regulator of RAS ubiquitination and signaling." Science 362, no. 6419 (2018): 1171–77. http://dx.doi.org/10.1126/science.aap8210.

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In genetic screens aimed at understanding drug resistance mechanisms in chronic myeloid leukemia cells, inactivation of the cullin 3 adapter protein-encoding leucine zipper-like transcription regulator 1 (LZTR1) gene led to enhanced mitogen-activated protein kinase (MAPK) pathway activity and reduced sensitivity to tyrosine kinase inhibitors. Knockdown of theDrosophila LZTR1orthologCG3711resulted in a Ras-dependent gain-of-function phenotype. Endogenous human LZTR1 associates with the main RAS isoforms. Inactivation ofLZTR1led to decreased ubiquitination and enhanced plasma membrane localizati

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25

Clark-Huckstep, Andrew E. "The History of Sexuality and Historical Methodology." Cultural History 5, no. 2 (2016): 179–99. http://dx.doi.org/10.3366/cult.2016.0125.

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Michel Foucault's The History of Sexuality has been the subject of debate among historians for decades. More specifically, his assertion, ‘the sodomite was a temporary aberration, the homosexual was now a species,’ has been used to support an ‘acts-to-identity’ theory that locates in the late-nineteenth century a shift in thinking about sexuality. The author argues that a re-reading of Foucault shifts the focus of historical inquiry from identities towards the process of knowledge creation, allowing for ambiguity that the concept ‘identity’ might foreclose. This essay examines the debate and o

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26

Liu, Zhongjiao, Kexuan Ma, Panpan Zhang, Siqi Zhang, Xin Song, and Yuqi Qin. "F-box protein Fbx23 acts as a transcriptional coactivator to recognize and activate transcription factor Ace1." PLOS Genetics 21, no. 1 (2025): e1011539. https://doi.org/10.1371/journal.pgen.1011539.

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Protein ubiquitination is usually coupled with proteasomal degradation and is crucial in regulating protein quality. The E3 ubiquitin-protein ligase SCF (Skp1-Cullin-F-box) complex directly recognizes the target substrate via interaction between the F-box protein and the substrate. F-box protein is the determinant of substrate specificity. The limited number of identified ubiquitin ligase-substrate pairs is a major bottleneck in the ubiquitination field. Penicillium oxalicum contains many transcription factors, such as BrlA, CreA, XlnR, and Ace1, conserved in filamentous fungi that regulate th

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27

Zou, Jianqiu, Wenxia Ma, Jie Li, et al. "Neddylation mediates ventricular chamber maturation through repression of Hippo signaling." Proceedings of the National Academy of Sciences 115, no. 17 (2018): E4101—E4110. http://dx.doi.org/10.1073/pnas.1719309115.

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During development, ventricular chamber maturation is a crucial step in the formation of a functionally competent postnatal heart. Defects in this process can lead to left ventricular noncompaction cardiomyopathy and heart failure. However, molecular mechanisms underlying ventricular chamber development remain incompletely understood. Neddylation is a posttranslational modification that attaches ubiquitin-like protein NEDD8 to protein targets via NEDD8-specific E1-E2-E3 enzymes. Here, we report that neddylation is temporally regulated in the heart and plays a key role in cardiac development. C

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Hedberg-Oldfors, Carola, Alexandra Abramsson, Daniel P. S. Osborn, et al. "Cardiomyopathy with lethal arrhythmias associated with inactivation of KLHL24." Human Molecular Genetics 28, no. 11 (2019): 1919–29. http://dx.doi.org/10.1093/hmg/ddz032.

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Abstract Hypertrophic cardiomyopathy (HCM) is the most common inherited cardiovascular disorder, yet the genetic cause of up to 50% of cases remains unknown. Here, we show that mutations in KLHL24 cause HCM in humans. Using genome-wide linkage analysis and exome sequencing, we identified homozygous mutations in KLHL24 in two consanguineous families with HCM. Of the 11 young affected adults identified, 3 died suddenly and 1 had a cardiac transplant due to heart failure. KLHL24 is a member of the Kelch-like protein family, which acts as substrate-specific adaptors to Cullin E3 ubiquitin ligases.

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Lutz, Lindy M., Chandler R. Pace, and Michelle M. Arnold. "Rotavirus NSP1 Associates with Components of the Cullin RING Ligase Family of E3 Ubiquitin Ligases." Journal of Virology 90, no. 13 (2016): 6036–48. http://dx.doi.org/10.1128/jvi.00704-16.

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ABSTRACTThe rotavirus nonstructural protein NSP1 acts as an antagonist of the host antiviral response by inducing degradation of key proteins required to activate interferon (IFN) production. Protein degradation induced by NSP1 is dependent on the proteasome, and the presence of a RING domain near the N terminus has led to the hypothesis that NSP1 is an E3 ubiquitin ligase. To examine this hypothesis, pulldown assays were performed, followed by mass spectrometry to identify components of the host ubiquitination machinery that associate with NSP1. Multiple components of cullin RING ligases (CRL

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30

Iheanacho, S. B. C., E. E. Ikpeme, and Idris A. Saba. "Eradication of Cultism in Nigeria Tertiary Institutions through Active Participation in Sport." Journal of Public Administration and Governance 3, no. 1 (2013): 88. http://dx.doi.org/10.5296/jpag.v3i1.3381.

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This paper focuses on sport as panacea for cultism in Nigerian tertiary institutions. The vices that stigmatized the tertiary institutions today are traceable to the uncontrolled behaviour of students. School authorities and concerned government over the years have applied measures to check the excesses of students in tertiary institutions without noticeable success. Sports stand to provide the needed solution to these linger problems of cultism in tertiary institutions. Sports is perceived as wholesome pursuits for students in tertiary institution which channel their thinking and disposition

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Vava, Akhona, Juliano D. Paccez, Yihong Wang, et al. "DCUN1D1 Is an Essential Regulator of Prostate Cancer Proliferation and Tumour Growth That Acts through Neddylation of Cullin 1, 3, 4A and 5 and Deregulation of Wnt/Catenin Pathway." Cells 12, no. 15 (2023): 1973. http://dx.doi.org/10.3390/cells12151973.

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Defective in cullin neddylation 1 domain containing 1 (DCUN1D1) is an E3 ligase for the neddylation, a post-translational process similar to and occurring in parallel to ubiquitin proteasome pathway. Although established as an oncogene in a variety of squamous cell carcinomas, the precise role of DCUN1D1 in prostate cancer (PCa) has not been previously explored thoroughly. Here, we investigated the role of DCUN1D1 in PCa and demonstrated that DCUN1D1 is upregulated in cell lines as well as human tissue samples. Inhibition of DCUN1D1 significantly reduced PCa cell proliferation and migration an

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Tanaka, Susumu, Yoshiko Honda, Misa Sawachika, Kensuke Futani, Namika Yoshida, and Tohru Kodama. "Degradation of STK16 via KCTD17 with Ubiquitin–Proteasome System in Relation to Sleep–Wake Cycle." Kinases and Phosphatases 1, no. 1 (2022): 14–22. http://dx.doi.org/10.3390/kinasesphosphatases1010003.

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Serine/threonine-protein kinase 16 (STK16) is a novel member of the Numb-associated family of protein kinases with an atypical kinase domain. In this study, we aimed to investigate the involvement of STK16 in sleep–wake mechanisms. We confirmed the expression of Stk16 in the murine hypothalamus, the sleep–wake center, and found considerable changes in STK16 protein levels in the anterior hypothalamus during the light–dark cycle. We found that the coexistence of the potassium channel tetramerization domain containing 17 (KCTD17), an STK16 interactor, caused STK16 degradation. In contrast, the p

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Rolemberg Santana Travaglini Berti de Correia, Camila, Caroline Torres, Ellen Gomes, et al. "Functional characterization of Cullin-1-RING ubiquitin ligase (CRL1) complex in Leishmania infantum." PLOS Pathogens 20, no. 7 (2024): e1012336. http://dx.doi.org/10.1371/journal.ppat.1012336.

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Cullin-1-RING ubiquitin ligases (CRL1) or SCF1 (SKP1-CUL1-RBX1) E3 ubiquitin ligases are the largest and most extensively investigated class of E3 ligases in mammals that regulate fundamental processes, such as the cell cycle and proliferation. These enzymes are multiprotein complexes comprising SKP1, CUL1, RBX1, and an F-box protein that acts as a specificity factor by interacting with SKP1 through its F-box domain and recruiting substrates via other domains. E3 ligases are important players in the ubiquitination process, recognizing and transferring ubiquitin to substrates destined for degra

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Torres, W., O. Tinoco, A. Huamantinco, E. Mialhe, and L. Conde. "Biorremediación del agua recirculante en cultivo de camarón blanco utilizando microbiota autóctona del mangle rojo." Revista del Instituto de investigación de la Facultad de minas, metalurgia y ciencias geográficas 21, no. 42 (2018): 55–62. http://dx.doi.org/10.15381/iigeo.v21i42.15787.

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The aquaculture activity in the white shrimp culture using recirculating water deteriorates the quality of the water by the hydrodynamic action of watermetabolites- organic matter, which generate negative impacts on the production of the crustacean. The objective of this research is to demonstrate that the autochthonous microbiota extracted from the red mangrove stimulates bioremediation. For this purpose, the microbiota was subjected to a process of bioaugmentation that enriches its biodiversity, so that when used, it guarantees bioremediation activity. The application of the treatment begins

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Shibata, Shigeru. "30 YEARS OF THE MINERALOCORTICOID RECEPTOR: Mineralocorticoid receptor and NaCl transport mechanisms in the renal distal nephron." Journal of Endocrinology 234, no. 1 (2017): T35—T47. http://dx.doi.org/10.1530/joe-16-0669.

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A key role of aldosterone and mineralocorticoid receptor is to regulate fluid volume and K+ homeostasis in the body by acting on the renal distal nephron. Global responses of the kidney to elevated aldosterone levels are determined by the coordinate action of different constituent tubule cells, including principal cells, intercalated cells and distal convoluted tubule cells. Recent studies on genetic mutations causing aldosterone overproduction have identified the molecules involved in aldosterone biosynthesis in the adrenal gland, and there is also increasing evidence for mechanisms and signa

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Babaei-Jadidi, Roya, Ningning Li, Anas Saadeddin, et al. "FBXW7 influences murine intestinal homeostasis and cancer, targeting Notch, Jun, and DEK for degradation." Journal of Experimental Medicine 208, no. 2 (2011): 295–312. http://dx.doi.org/10.1084/jem.20100830.

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The Fbxw7 (F-box/WD repeat–containing protein 7; also called CDC4, Sel10, Ago, and Fbw7) component of the SCF (Skp1/Cullin/F-box protein) E3 ubiquitin ligase complex acts as a tumor suppressor in several tissues and targets multiple transcriptional activators and protooncogenes for ubiquitin-mediated degradation. To understand Fbxw7 function in the murine intestine, in this study, we specifically deleted Fbxw7 in the murine gut using Villin-Cre (Fbxw7ΔG). In wild-type mice, loss of Fbxw7 in the gut altered homeostasis of the intestinal epithelium, resulted in elevated Notch and c-Jun expressio

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Iso, Tatsuro, Takafumi Suzuki, Liam Baird, and Masayuki Yamamoto. "Absolute Amounts and Status of the Nrf2-Keap1-Cul3 Complex within Cells." Molecular and Cellular Biology 36, no. 24 (2016): 3100–3112. http://dx.doi.org/10.1128/mcb.00389-16.

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The transcription factor Nrf2 (NF-E2-related-factor 2) is essential for the oxidative and electrophilic stress responses. Keap1 (Kelch-like-ECH-associated-protein 1), an adaptor for a cullin-3 (Cul3)-based ubiquitin ligase, regulates Nrf2 activity through proteasomal degradation, and acts as a sensor for oxidative and electrophilic stresses. The Keap1-Cul3 complex is a critical regulator of the cellular Nrf2 level, and yet quantitative information regarding their endogenous intracellular concentrations in homeostatic conditions and during stress responses is unknown. We analyzed the absolute a

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Kondo-Okamoto, Noriko, Kentaro Ohkuni, Katsumi Kitagawa, J. Michael McCaffery, Janet M. Shaw, and Koji Okamoto. "The Novel F-Box Protein Mfb1p Regulates Mitochondrial Connectivity and Exhibits Asymmetric Localization in Yeast." Molecular Biology of the Cell 17, no. 9 (2006): 3756–67. http://dx.doi.org/10.1091/mbc.e06-02-0145.

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Although it is clear that mitochondrial morphogenesis is a complex process involving multiple proteins in eukaryotic cells, little is known about regulatory molecules that modulate mitochondrial network formation. Here, we report the identification of a new yeast mitochondrial morphology gene called MFB1 (YDR219C). MFB1 encodes an F-box protein family member, many of which function in Skp1-Cdc53/Cullin-F-box protein (SCF) ubiquitin ligase complexes. F-box proteins also act in non-SCF complexes whose functions are not well understood. Although cells lacking Mfb1p contain abnormally short mitoch

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An, Hyun-Jung, Cheol-Jung Lee, Ga-Eun Lee, et al. "FBXW7-mediated ERK3 degradation regulates the proliferation of lung cancer cells." Experimental & Molecular Medicine 54, no. 1 (2022): 35–46. http://dx.doi.org/10.1038/s12276-021-00721-9.

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AbstractExtracellular signal-regulated kinase 3 (ERK3) is an atypical member of the mitogen-activated protein kinase (MAPK) family, members of which play essential roles in diverse cellular processes during carcinogenesis, including cell proliferation, differentiation, migration, and invasion. Unlike other MAPKs, ERK3 is an unstable protein with a short half-life. Although deubiquitination of ERK3 has been suggested to regulate the activity, its ubiquitination has not been described in the literature. Here, we report that FBXW7 (F-box and WD repeat domain-containing 7) acts as a ubiquitination

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Brooks, Seth, та Jason Pfeiffer. "The ubiquitin E3 ligase Cul4B regulates TTP protein turnover and TNFα mRNA stability independent of p38 (57.6)". Journal of Immunology 186, № 1_Supplement (2011): 57.6. http://dx.doi.org/10.4049/jimmunol.186.supp.57.6.

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Abstract TNFα is a central mediator of inflammation and is critical for host response to infection and injury. TNFα biosynthesis is controlled by transcriptional and post-transcriptional mechanisms allowing for rapid, transient production. Tristetraprolin (TTP) is an AU-Rich Element binding protein that regulates the stability of TNFα mRNA. Previous work has demonstrated that TTP function is regulated by activation of both the p38 and ERK kinase pathways and that TTP protein is rapidly degraded by a proteasomal mechanism. Using a novel screen for TTP interacting proteins, we identified Cullin

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Muromoto, Ryuta, та Tadashi Matsuda. "Jun activation domain-binding protein 1 (JAB1)/CSN5 is required for the optimal response to interferon-α. (P6313)". Journal of Immunology 190, № 1_Supplement (2013): 184.18. http://dx.doi.org/10.4049/jimmunol.190.supp.184.18.

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Abstract Degradation of IFNAR1 protein is one of the mechanisms limiting the extent of cellular responses to type I interferon. Tyrosine kinase 2 (TYK2), a JAK family kinase, has been reported to bind and stabilize the basal IFNAR1 protein level, indicating that TYK2 is a fundamental component of IFN receptor complex. In this study, we identified Jun activation domain-binding protein 1 (JAB1; also known as fifth subunit of COP9-signalosome, CSN5) as a new TYK2 binding partner and investigated the role of JAB1 in the regulation of IFN responses. Knock-down of JAB1 by siRNA resulted in the suppr

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Hartley-Brown, Monique A., Clifton C. Mo, Omar Nadeem, Shonali Midha, Jacob P. Laubach, and Paul G. Richardson. "Mezigdomide—A Novel Cereblon E3 Ligase Modulator under Investigation in Relapsed/Refractory Multiple Myeloma." Cancers 16, no. 6 (2024): 1166. http://dx.doi.org/10.3390/cancers16061166.

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Mezigomide is an oral cereblon E3 ligase modulator (CELMoD) that is under clinical investigation in patients with relapsed/refractory (RR) multiple myeloma (MM). Like other CELMoD compounds, mezigdomide acts by altering the conformation of cereblon within the cullin 4A ring ligase–cereblon (CRL4CRBN) E3 ubiquitin ligase complex, thereby recruiting novel protein substrates for selective proteasomal degradation. These include two critical lymphoid transcription factors, Ikaros family zinc finger proteins 1 and 3 (IKZF1 and IKZF3), also known as Ikaros and Aiolos, which have important roles in th

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Albert, Sonia París. "el cultivo de las emociones a través de una educación emocional en la filosofía con niñas y niños." childhood & philosophy 18 (April 27, 2022): 01–22. http://dx.doi.org/10.12957/childphilo.2022.58561.

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Clarifying the concept of emotions is an essential task of 21st century societies. We cannot continue living if we ignore the importance they have in our everyday thinking and acting. Emotions are fundamental both to the private and the public sphere It is becoming increasingly important to learn to identify what we feel and what those around us feel, how we express these feelings and understand their consequences, in order to enable us to transform harmful emotions into others more favorable to the well-being of our personal relationships and our relationship with the environment. With this o

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Mitchell, Jonathan K., Nathaniel M. Byers, and Paul D. Friesen. "Baculovirus F-Box Protein LEF-7 Modifies the Host DNA Damage Response To Enhance Virus Multiplication." Journal of Virology 87, no. 23 (2013): 12592–99. http://dx.doi.org/10.1128/jvi.02501-13.

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The DNA damage response (DDR) of a host organism represents an effective antiviral defense that is frequently manipulated and exploited by viruses to promote multiplication. We report here that the large DNA baculoviruses, which require host DDR activation for optimal replication, encode a conserved replication factor, LEF-7, that manipulates the DDR via a novel mechanism. LEF-7 suppresses DDR-induced accumulation of phosphorylated host histone variant H2AX (γ-H2AX), a critical regulator of the DDR. LEF-7 was necessary and sufficient to block γ-H2AX accumulation caused by baculovirus infection

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45

Schwörer, Tobias. "The Red Flag of Peace: Colonial Pacification, Cargo Cults and the End of War among the South Fore." Anthropologica 56, no. 2 (2014): 341–52. https://doi.org/10.5281/zenodo.4118369.

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Warfare among the South Fore ceased quickly after first contact in 1949. Three aspects of the process of colonial pacification profoundly changed incentive structures for local warfare: punishment by force of those groups continuing acts of aggression, incentives for giving up warfare and the emergence of hybrid forms of judicial institutions to peacefully settle conflicts. The Fore stress their own agency in ending warfare, mainly through participation in cargo cult movements with promises of valuables and "new things to come," which made it possible for all groups to end war at the

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Goes, Thais Monteiro, Sandra Helena Isse Polaro, and Lucia Hisako Takase Gonçalves. "CULTIVO DO BEM VIVER DAS PESSOAS IDOSAS E TECNOLOGIA CUIDATIVO-EDUCACIONAL DE ENFERMAGEM." Enfermagem em Foco 7, no. 2 (2016): 47. http://dx.doi.org/10.21675/2357-707x.2016.v7.n2.794.

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Objetivo: realizar avaliação diagnóstica de condições de vida e saúde dos idosos convivendo em família e comunidade, usuários de uma Unidade Básica de Saúde – UBS e testar o desenvolvimento de uma tecnologia cuidativo-educacional. Metodologia: pesquisa convergente-assistencial, adotando a técnica do grupo de convergência com 13 idosos, que se desenvolveu em sete encontros, em 2013. Resultados: o estudo revelou perspectivas à enfermeira ser facilitadora no desenvolvimento de competências ao autocuidado e estimuladora de idosos para que sejam protagonistas do próprio envelhecimento, instrumental

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NUNES, ALINE MARA CHAVES, Ana Janaina Oliveira Rodrigues, MARCIO PORFIRIO DA SILVA, GÉSSICA THAÍS DOS SANTOS MOURA, and KELINE SOUSA ALBUQUERQUE UCHÔA. "EFEITO DA ADUBAÇÃO SILICATADA NO CULTIVO DO TOMATEIRO SOB ESTRESSE HÍDRICO." IRRIGA 1, no. 2 (2018): 29–33. http://dx.doi.org/10.15809/irriga.2018v1n2p29-33.

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EFEITO DA ADUBAÇÃO SILICATADA NO CULTIVO DO TOMATEIRO SOB ESTRESSE HÍDRICO   ALINE MARA CHAVES NUNES¹; ANA JANAINA OLIVEIRA RODRIGUES2; MARCIO PORFIRIO DA SILVA2; GÉSSICA THAÍS DOS SANTOS MOURA2 E KELINE SOUSA ALBUQUERQUE UCHÔA3  1 Engenheiro Agrônoma, Instituto Federal do Ceará – IFCE – campus Limoeiro do Norte, Rua Estevão Remígio, nº 1145, bairro Centro. CEP: 62930-000. Limoeiro do Norte-CE. E-mail: mc_nunes@hotmail.com 2 Mestrando, Departamento de Engenharia Agrícola – Universidade Federal do Ceará – UFC, Av. Mister Hull, s/n - Campus do Pici - CEP 60.02

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Chen, Bo, Yanrong Lu, Younan Chen, and Jingqiu Cheng. "The role of Nrf2 in oxidative stress-induced endothelial injuries." Journal of Endocrinology 225, no. 3 (2015): R83—R99. http://dx.doi.org/10.1530/joe-14-0662.

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Endothelial dysfunction is an important risk factor for cardiovascular disease, and it represents the initial step in the pathogenesis of atherosclerosis. Failure to protect against oxidative stress-induced cellular damage accounts for endothelial dysfunction in the majority of pathophysiological conditions. Numerous antioxidant pathways are involved in cellular redox homeostasis, among which the nuclear factor-E2-related factor 2 (Nrf2)/Kelch-like ECH-associated protein 1 (Keap1)–antioxidant response element (ARE) signaling pathway is perhaps the most prominent. Nrf2, a transcription factor w

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Liu, Liang, Xiaodong Chen, Kaizong Huang, et al. "Ubiquitin ligase subunit FBXO9 inhibits V-ATPase assembly and lung cancer metastasis." Journal of Clinical Oncology 42, no. 16_suppl (2024): e20520-e20520. http://dx.doi.org/10.1200/jco.2024.42.16_suppl.e20520.

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e20520 Background: The evolutionarily conserved protein FBXO9 acts as a substrate receptor for the SKP1-cullin-1-RBX1 ubiquitin ligase and is implicated in cancer, exhibiting either tumor-suppressive or oncogenic effects depending on the specific tumor type. However, their role in lung cancer metastasis remains unclear. Methods: Lentiviral vectors carrying miRNA-based shRNA sequences for gene-specific knockdown were generated, and Lenti-CRISPR-Cas9 vectors containing gene-specific sgRNA sequences were designed. Gene overexpression was achieved using doxycycline-inducible lentiviral constructs,

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Ms.Krishnappriya.N and Monsingh Ms.Geetha. "Form Based Codes for the Revitalization of Urban Roads with Cultural Context in Myilai- Teynampet Region, Chennai." International Journal of Recent Research in Thesis and Dissertation (IJRRTD) 5, no. 1 (2024): 120–25. https://doi.org/10.5281/zenodo.11118976.

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<strong>Abstract:</strong><em> </em>Cities are today home to more than half the world’s population. The crucial role of cities in promoting sustainable development focused on people and the respect of human rights is notably recognized in the 2030 Agenda for Sustainable Development which includes among its 17 goals a specific objective to ‘make cities and human settlements inclusive, safe, resilient and sustainable’ and identifies culture and creativity as one of the essential levers for action. In this context culture acts as an integral factor for sustainable urban developm

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