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Tesis sobre el tema "Cyanobacteria Toxicology"

Autor: Grafiati

Publicado: 4 de junio de 2021

Última modificación: 31 de enero de 2023

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1

Froscio, Suzanne M. "Investigation of the mechanisms involved in cylindrospermopsin toxicity : hepatocyte culture and reticulocyte lysate studies." Title page, contents and abstract only, 2002. http://web4.library.adelaide.edu.au/theses/09PH/09phf938.pdf.

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Bibliography: leaves 121-139. The aim of this study was to determine the extent to which protein synthesis inhibition, lowered glutathione (GSH) levels and toxin metabolism contribute to the toxicity of cyclindrospermopsin. Both hepatocyte cultures and reticulocyte lysates were utilized as in vitro tools of investigation. The findings imply that the inhibition of protein synthesis by direct action of the toxin cannot be considered a primary cause of hepatocyte cell death over an acute time frame. Cytochrome P450-derived metabolites may play a crucial role in cytotoxicity, and the toxicity proc

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2

Niyonzima, Francois Niyongabo. "Bioaccumulation and ecotoxicology of b-methylamino-l-alanine (BMAA) in model crop plants." Thesis, Nelson Mandela Metropolitan University, 2010. http://hdl.handle.net/10948/1475.

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Cyanobacteria are known to produce a variety of toxic compounds. β-N-methylamino-L-alanine (BMAA) is one of the neurotoxins produced by most cyanobacteria. BMAA has been implicated in amyotrophic lateral sclerosis / Parkinsonism dementia complex (ALS / PDC) and was suggested to contribute to this pathology after biomagnification and slow release of BMAA from a protein associated form. The uptake and accumulation of BMAA by the aquatic macrophyte Ceratophyllum demersum has recently been shown, but the consumption of aquatic macrophytes by humans is not typical. The uptake by, and accumulation i

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3

Humpage, Andrew Raymond. "Tumour promotion by the cyanobacterial toxin microcystin /." Title page, contents and abstract only, 1997. http://web4.library.adelaide.edu.au/theses/09PH/09phh9258.pdf.

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4

Giles, Jonathan. "Mathematical modelling of the development of cyanobacteria (blue-green algae) in an eutrophical lake, including aspects of toxicology." Thesis, University of South Wales, 1998. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.284893.

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5

Brookes, Justin Dean. "The influence of nutrients and light on the metabolic activity and buyoancy of Microcystis aeruginosa and Anabaena circinalis /." Title page, contents and summary only, 1997. http://web4.library.adelaide.edu.au/theses/09PH/09phb8711.pdf.

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6

Sampaio, Joseane. "Cianopeptídeos inibidores de proteases produzidos por cianobactérias brasileiras." Universidade de São Paulo, 2012. http://www.teses.usp.br/teses/disponiveis/9/9141/tde-08032013-153415/.

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As cianobactérias são micro-organismos reconhecidos por seu potencial em produzir cianotoxinas que afetam não só o ecossistema e a outros organismos dos ambientes aquáticos, mas também aos seres humanos, agindo em diversos órgãos e tecidos. Cerca de 600 metabólitos secundários produzidos por cianobactérias já foram descritos na literatura, sendo que muitos deles possuem potencial biológico. Os peptídeos de baixo peso molecular, produzidos por cianobactérias chamados cianopeptídeos, dos quais se podem citar as anabaenopeptinas, aeruginosinas, microviridinas, cianopeptolinas e microgininas, são

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7

Zajac, Meron Petro. "Investigação da cilidrospermopsina e PSPs em amostras de águas superficiais no Estado de São Paulo (OU) Investigação da presença de cilindrospermopsina e saxitoxinas em amostras de águas superficiais no Estado de São Paulo." Universidade de São Paulo, 2006. http://www.teses.usp.br/teses/disponiveis/9/9141/tde-27102009-120004/.

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O crescimento desordenado das cidades tem trazido à tona problemas de saneamento e degradação dos recursos naturais, entre eles a água. O despejo de efluentes domésticos e industriais têm ocasionado a eutrofização dos mananciais, culminando com a proliferação dos fitoplânctons. Esta proliferação tem chegado ao ponto, em certos momentos, de acarretar episódios de floração de algas. Entre os organismos fitoplanctônicos que se desenvolvem no ambiente, estão as cianobactérias, com vários gêneros capazes de produzir diversas cianotoxinas, tais como as microcistinas, anatoxinas, cilindrospermopsinas

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8

Bortoli, Stella de. "Investigação da biossíntese de toxinas produzidas por cepas de cianobactérias." Universidade de São Paulo, 2011. http://www.teses.usp.br/teses/disponiveis/9/9141/tde-29092011-164054/.

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A demanda crescente de água doce de boa qualidade são problemas atuais e mundiais, além do descaso com os dejetos lançados nos ambientes aquáticos que comprometem a qualidade dos recursos hídricos. Um dos parâmetros que atesta a potabilidade da água é a presença de cianobactérias e cianotoxinas. Cianobactérias são microrganismos procariontes aeróbicos fotoautróficos que sintetizam as cianotoxinas. Estes compostos podem ser classificados de acordo com seus mecanismos de ação em hepatotóxicos, neurotóxicos e dermatotóxicos. Por sua diversidade, representam diferentes riscos não só ao ecossistema

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9

Müller, Luciana. "Avaliação da toxicidade e degradação de M. aeruginosa e Microcistina-LR por AOPs e nanopartículas de prata." Universidade Tecnológica Federal do Paraná, 2017. http://repositorio.utfpr.edu.br/jspui/handle/1/2601.

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Florações de cianobactérias são facilmente encontradas, devido ao crescente aporte de nutrientes nos corpos de águas naturais e artificiais, ocasionado pelos acelerados processos de eutrofização frutos da ocupação urbana e rural sem a observação de critérios mínimos. Microcystis aeruginosa é uma espécie de cianobactéria potencialmente produtora de cianotoxinas, comumente associada a casos de intoxicação em escala mundial. Novas tecnologias para o tratamento de água têm sido implementadas para cumprimento dos padrões de potabilidade exigidos pela legislação. O presente trabalho buscou analisar

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10

Norris, Ross L. G. "Toxicology of compounds from the cyanobacterium Cylindrospermopsis raciborskii /." [St. Lucia, Qld.], 2002. http://www.library.uq.edu.au/pdfserve.php?image=thesisabs/absthe16950.pdf.

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11

Carvalho, Maiara Soares de. "Aplicação da Moringa oleifera na remoção de células de Microcystis aeruginosa e metabólitos por flotação por ar dissolvido e filtração rápida." Universidade Tecnológica Federal do Paraná, 2015. http://repositorio.utfpr.edu.br/jspui/handle/1/1197.

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CNPq<br>Florações de cianobactérias em reservatórios de abastecimento de água têm ocorrido com uma frequência cada vez maior, causando diversos problemas de ordem operacional nos sistemas de tratamento de água em decorrência da elevada densidade de células, além de preocupações quanto à eficiência do tratamento na remoção de metabólitos como cianotoxinas e compostos odoríferos. Este trabalho teve por objetivo avaliar a aplicabilidade da Moringa oleifera Lam pura e associada ao policloreto de alumínio (PACl) na remoção de células de Microcystis aeruginosa, microcistinas, 2-MIB e geosmina por me

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12

Karlsson, Oskar. "Distribution and Long-term Effects of the Environmental Neurotoxin β-N-methylamino-L-alanine (BMAA) : Brain changes and behavioral impairments following developmental exposure". Doctoral thesis, Uppsala universitet, Institutionen för farmaceutisk biovetenskap, 2010. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-140785.

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Many cyanobacteria are reported to produce the nonprotein amino acid β-N-methylamino-L-alanine (BMAA). Cyanobacteria are extensively distributed in terrestrial and aquatic environments and recently BMAA was detected in temperate aquatic ecosystems, e.g. the Baltic Sea. Little is known about developmental effects of the mixed glutamate receptor agonist BMAA. Brain development requires an optimal level of glutamate receptor activity as the glutamatergic system modulates many vital neurodevelopmental processes. The aim of this thesis was to investigate the developmental neurotoxicity of BMAA, and

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13

Osborne, Nicholas John Thomas. "Investigation of the toxicology and public health aspects of the marine cyanobacterium, Lyngbya majuscula /." [St. Lucia, Qld.], 2004. http://www.library.uq.edu.au/pdfserve.php?image=thesisabs/absthe18107.pdf.

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14

Bain, Peter A., and n/a. "Gene Expression Profiling of Cylindrospermopsin Toxicity." Griffith University. School of Biomolecular and Physical Sciences, 2007. http://www4.gu.edu.au:8080/adt-root/public/adt-QGU20080404.145834.

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Cylindrospermopsin (CYN) is a toxic alkaloid produced by several freshwater cyanobacterial species, the most prevalent in Australian waters being Cylindrospermopsis raciborskii. The occurrence of CYN-producing cyanobacteria in drinking water sources worldwide poses a potential human health risk, with one well-documented case of human poisoning attributed to the toxin. While extensive characterisation of CYN-induced toxicity has been conducted in rodents both in vivo and in primary cell cultures, little is known about mechanisms of toxicity in human cell types. This thesis describes studies und

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15

Gomes, Camila Queiroz. "Caracterização de Geitlerinema UFV-E01 (Cyanobacteria) e Stigeoclonium UFV- E02 (Chlorophyta) cultivadas em presença de arsênio." Universidade Federal de Viçosa, 2005. http://www.locus.ufv.br/handle/123456789/8844.

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Submitted by Marco Antônio de Ramos Chagas (mchagas@ufv.br) on 2016-10-17T15:58:03Z No. of bitstreams: 1 texto completo.pdf: 919530 bytes, checksum: 79e4c5e2a21091121057607849cdca46 (MD5)<br>Made available in DSpace on 2016-10-17T15:58:03Z (GMT). No. of bitstreams: 1 texto completo.pdf: 919530 bytes, checksum: 79e4c5e2a21091121057607849cdca46 (MD5) Previous issue date: 2005-02-18<br>Coordenação de Aperfeiçoamento de Pessoal de Nível Superior<br>As cianobactérias e algas são organismos encontrados, abundantemente, em ambientes aquáticos, onde atuam como produtores primários transferindo e

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16

Qiao, Qin. "Reprotoxic effects of microcystins and secondary metabolites produced by cyanobacteria Microcystis in adult medaka fish." Thesis, Paris, Muséum national d'histoire naturelle, 2016. http://www.theses.fr/2016MNHN0022/document.

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Les efflorescences de cyanobactéries sont susceptibles d’avoir des effets néfastes sur les organismes des écosystèmes aquatiques, ainsi que sur les populations environnantes, notamment à travers la production de nombreuses molécules potentiellement toxiques (appelées cyanotoxines). Jusqu'à présent, une des cyanotoxines les plus étudiées est la microcystine (MC). Cette thèse a pour objectif d’évaluer la toxicité potentielle sur la reproduction de la MC-LR et de l'extrait d'une souche de Microcystis productrice de MCs en étudiant leurs effets toxiques sur le foie et les gonades de poissons medak

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17

Downing, T. G. "The role of nitrogen in the regulation of microcystin content in Microcystis aeruginosa." Thesis, Stellenbosch : Stellenbosch University, 2005. http://hdl.handle.net/10019.1/50523.

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Thesis (PhD)--University of Stellenbosch, 2005.<br>ENGLISH ABSTRACT: Several genera of cyanobacteria produce a range of toxins. The increased rate of eutrophication of surface fresh waters due to anthropogenic inputs has resulted in more frequent and severe cyanobacterial bloom events. Such bloom events make impoundments unsuitable for recreational use and increase the cost of production of potable water due to the necessity for removal of toxins released from cells during the purification process. Microcystis aeruginosa is the major freshwater bloom-forming toxic cyanobacterium. Conce

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18

Sabart, Marion. "Variations spatiotemporelles dans la dynamique, la diversité génétique et le potentiel toxique de populations de Microcystis aeruginosa (Cyanobacteria) dans plusieurs écosystèmes aquatiques du centre de la France." Chambéry, 2009. http://www.theses.fr/2009CHAMS039.

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Les proliférations de cyanobactéries dans les milieux aquatiques continentaux représentent un problème environnemental, économique et sanitaire, notamment à cause de la capacité de certains genres à produire des toxines. En étudiant les variations spatio-temporelles de la diversité génétique et du potentiel toxique de populations de la cyanobactérie hépatotoxique Microcystis dans différents types d'écosystèmes aquatiques (retenues, étangs, fleuve) situés dans une même aire géographique, nous avons montré une structuration génétique des populations ainsi que d'importantes différences du potenti

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19

Misson, Benjamin Olivier. "Potentiel toxique et structure génétique de populations de Microcystis en lien avec les différentes phases de son cycle de vie." Thesis, Clermont-Ferrand 2, 2011. http://www.theses.fr/2011CLF22168/document.

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L‟eutrophisation croissante des écosystèmes aquatiques favorise le développement des cyanobactéries, parmi lesquelles Microcystis est la plus représentée dans les régions tempérées. La capacité de Microcystis à produire une puissante hépatotoxine, la microcystine, est à l‟origine de diverses perturbations écologiques, et de nombreuses nuisances sanitaires. La compréhension des facteurs déterminant la toxicité des efflorescences de Microcystis constitue, de fait, un enjeu majeur des recherches actuelles. Dans ce contexte, l‟objectif premier de ce travail de thèse était d‟étudier la variabilité

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20

De, Boutray Marie-Laure. "Les cyanobactéries et leurs toxines dans les sources d’eau potable." Thesis, Paris Est, 2017. http://www.theses.fr/2017PESC1069/document.

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La prolifération grandissante des épisodes de fleurs d’eau de cyanobactéries toxiques dans les plans d'eau potable et dans les usines de traitement d'eau potable est une préoccupation mondiale. L’utilisation de sondes in vivo, permettant la détection de la phycocyanine des cyanobactéries par fluorescence, est une technologie innovante, de plus en plus couramment utilisée. Néanmoins, pour favoriser son implémentation à grande échelle, elle doit être validée scientifiquement. De nombreuses sources d’interférences dans ces sondes sont à l’origine de biais de lecture. Les objectifs de cette recher

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21

Boyaud, France. "Synthèse totale de la laxaphycine B : un lipopeptide cyclique d’origine marine : extension à d’autres peptides apparentés." Thesis, Montpellier 2, 2013. http://www.theses.fr/2013MON20083.

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Le milieu marin représente une source d'inspiration pour les chimistes, grâce à l'incroyable diversité structurale des composés isolés des organismes et micro-organismes marins. Parmi eux, la laxaphycine B, un lipopeptide cyclique isolée de la cyanobactérie Anabaena torulosa est comme la plupart des peptides marins produit selon une voie de biosynthèse non ribosomale « NRPS /PKS » et présente une forte activité cytotoxique sur différentes lignées cellulaires cancéreuses. Une des problématiques de ce lipopeptide est l'absence d'information sur son mécanisme d'action. Afin d'identifier des cible

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22

Silva, Sidnei Moura e. "Síntese e aplicações estratégicas de algumas neurotoxinas produzidas por cianobactérias." Universidade de São Paulo, 2009. http://www.teses.usp.br/teses/disponiveis/9/9141/tde-21052009-145829/.

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As cianobactérias apresentam distribuição variada e podem ocorrer desde as regiões frias do ártico até os trópicos, em corpos dágua doce e no ambiente marinho. Algumas espécies de cianobactérias produzem compostos com conhecida toxidade, podendo causar efeitos deletérios em seres humanos e animais. Entre estes compostos estão os com atividade neurotóxica devido aos mais variados mecanismos de ação. O objetivo geral deste projeto é a obtenção por via sintética de algumas neurotoxinas e variantes, entre elas a β-N-metil-L-alanina (L-BMAA), anatoxina-a e anatoxina-a(s), bem como algumas apli

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23

Vergalli, Julia. "Versatilité écologique de la cyanobactérie potentiellement toxique Planktothrix agardhii : influence de la salinité?" Thesis, Aix-Marseille, 2013. http://www.theses.fr/2013AIXM4309.

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La recherche a été initiée par l'observation d'efflorescences de Planktothrix agardhii, une cyanobactérie dulçaquicole potentiellement toxique, dans deux étangs saumâtres, les étangs de l'Olivier et de Bolmon, avec dans ce dernier le déclin de l'espèce concomitamment à une augmentation de salinité. L'objectif de l'étude consistait à évaluer l'influence de la salinité du milieu sur la performance, l'hégémonie et la production de toxine de Planktothrix agardhii au sein de la communauté phytoplanctonique.La réalisation de suivis pluriannuels in situ couplés à des expérimentations en milieu contrô

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24

Mbukwa, Elbert Anyambilile. "Selective bio-analytical methods for specific identification and detection of toxic microcystis species and microcystins in water." Thesis, 2013. http://hdl.handle.net/10210/8541.

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25

Humpage, Andrew Raymond. "Tumour promotion by the cyanobacterial toxin microcystin / by Andrew Raymond Humpage." Thesis, 1997. http://hdl.handle.net/2440/19139.

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Bibliography: leaves 235-265.<br>xvi, 265 leaves : ill. ; 30 cm.<br>Examines the tumour promoting effects of the microcystins through a long-term study in which cyanobacterial extract containing a range of microcystins was given in drinking water to mice previously treated with the tumour initiator N-nitroso-N-methyluren by gavage ; and through examining the effects of pure microcystin-LR in cultured primary hepatocytes from immature mice.<br>Thesis (Ph.D.)--University of Adelaide, Dept. of Clinical and Experimental Pharmacology, 1998?

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26

Bezuidenhout, Nelanie. "An investigation into the cyanobacteria and related cyanotoxins in the Vaalkop dam and Vaalkop Treatment Plant, Rustenburg." Thesis, 2013. http://hdl.handle.net/10210/8544.

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M.Sc. (Environmental Management)<br>In South Africa, there are practically no freshwater lakes. Therefore, exploitable water supplies are confined to rivers, artificial lakes behind dams, and groundwater. The many demands for water, and the erratic flow of most South African rivers, have led to the creation of artificial lakes and dams, i.e. impoundments on all the major rivers, in order to stabilise flow and therefore guarantee annual water supply. Cyanobacterial bloom formation in freshwater sources, such as rivers, lakes, dams and reservoirs are known to occur throughout the world. In South

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27

John, Wilson. "Capillary electrophoresis and related techniques for the analysis of fresh water algal toxins." Thesis, 1997. http://hdl.handle.net/10413/4868.

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As cyanobacteria (also known as blue green algae) produce a range of cyclic peptides which are highly toxic, capillary electrophoresis and associated techniques have been investigated to assess their applicability for toxin monitoring in the water bodies of kwaZulu Natal, South Africa. Capillary electrophoresis (CE) is a technique in which charged molecules can be efficiently separated in a buffer solution within a capillary tube under the influence of a strong electric field. Two CE modes, namely capillary zone electrophoresis (CZE) and micellar electrokinetic capillary chromatography (

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