Bibliografías temáticas / Dark kinase

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Literatura académica sobre el tema "Dark kinase"

Autor: Grafiati
Publicado: 6 de enero de 2025
Última modificación: 31 de julio de 2025

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Artículos de revistas sobre el tema "Dark kinase"

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Plutzer, Isaac, Dhaval P. Bhatt, Emily M. Wilkerson, Regan Williamson, Dennis Goldfarb, and M. Ben Major. "Abstract 4126: Illuminating the dark kinome using proximity labeling and phosphoproteomics analysis." Cancer Research 85, no. 8_Supplement_1 (2025): 4126. https://doi.org/10.1158/1538-7445.am2025-4126.

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Kinases are highly druggable targets for cancer therapy due to their control over a variety of oncogenic processes via protein phosphorylation. While, large clinical phosphoproteomics datasets have expanded our understanding of how the phosphoproteome is altered in cancer, annotation of the phosphoproteome is significantly lacking. 95% of phosphorylation sites in the PhosphoSitePlus database have no associated kinase, and 80% of annotated substrates are assigned to just 20% of the most well-studied kinases. Of the ∼650 kinases in the human genome, 162 are designated by the NIH as ‘dark kinases
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Soleymani, Saber, Nathan Gravel, Liang-Chin Huang, et al. "Dark kinase annotation, mining, and visualization using the Protein Kinase Ontology." PeerJ 11 (December 5, 2023): e16087. http://dx.doi.org/10.7717/peerj.16087.

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The Protein Kinase Ontology (ProKinO) is an integrated knowledge graph that conceptualizes the complex relationships among protein kinase sequence, structure, function, and disease in a human and machine-readable format. In this study, we have significantly expanded ProKinO by incorporating additional data on expression patterns and drug interactions. Furthermore, we have developed a completely new browser from the ground up to render the knowledge graph visible and interactive on the web. We have enriched ProKinO with new classes and relationships that capture information on kinase ligand bin
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Needham, Elise J., Benjamin L. Parker, Timur Burykin, David E. James, and Sean J. Humphrey. "Illuminating the dark phosphoproteome." Science Signaling 12, no. 565 (2019): eaau8645. http://dx.doi.org/10.1126/scisignal.aau8645.

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Protein phosphorylation is a major regulator of protein function and biological outcomes. This was first recognized through functional biochemical experiments, and in the past decade, major technological advances in mass spectrometry have enabled the study of protein phosphorylation on a global scale. This rapidly growing field of phosphoproteomics has revealed that more than 100,000 distinct phosphorylation events occur in human cells, which likely affect the function of every protein. Phosphoproteomics has improved the understanding of the function of even the most well-characterized protein
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Sawyers, Charles L. "Will Kinase Inhibitors Have a Dark Side?" New England Journal of Medicine 355, no. 3 (2006): 313–15. http://dx.doi.org/10.1056/nejmcibr062354.

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Southekal, Siddesh, Nitish Kumar Mishra, and Chittibabu Guda. "Pan-Cancer Analysis of Human Kinome Gene Expression and Promoter DNA Methylation Identifies Dark Kinase Biomarkers in Multiple Cancers." Cancers 13, no. 6 (2021): 1189. http://dx.doi.org/10.3390/cancers13061189.

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Kinases are a group of intracellular signaling molecules that play critical roles in various biological processes. Even though kinases comprise one of the most well-known therapeutic targets, many have been understudied and therefore warrant further investigation. DNA methylation is one of the key epigenetic regulators that modulate gene expression. In this study, the human kinome’s DNA methylation and gene expression patterns were analyzed using the level-3 TCGA data for 32 cancers. Unsupervised clustering based on kinome data revealed the grouping of cancers based on their organ level and ti
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Berginski, Matthew E., Nienke Moret, Changchang Liu, Dennis Goldfarb, Peter K. Sorger, and Shawn M. Gomez. "The Dark Kinase Knowledgebase: an online compendium of knowledge and experimental results of understudied kinases." Nucleic Acids Research 49, no. D1 (2020): D529—D535. http://dx.doi.org/10.1093/nar/gkaa853.

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Abstract Kinases form the backbone of numerous cell signaling pathways, with their dysfunction similarly implicated in multiple pathologies. Further facilitated by their druggability, kinases are a major focus of therapeutic development efforts in diseases such as cancer, infectious disease and autoimmune disorders. While their importance is clear, the role or biological function of nearly one-third of kinases is largely unknown. Here, we describe a data resource, the Dark Kinase Knowledgebase (DKK; https://darkkinome.org), that is specifically focused on providing data and reagents for these
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Anandakrishnan, Manju, Karen E. Ross, Chuming Chen, Vijay Shanker, Julie Cowart, and Cathy H. Wu. "KSFinder—a knowledge graph model for link prediction of novel phosphorylated substrates of kinases." PeerJ 11 (October 6, 2023): e16164. http://dx.doi.org/10.7717/peerj.16164.

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Background Aberrant protein kinase regulation leading to abnormal substrate phosphorylation is associated with several human diseases. Despite the promise of therapies targeting kinases, many human kinases remain understudied. Most existing computational tools predicting phosphorylation cover less than 50% of known human kinases. They utilize local feature selection based on protein sequences, motifs, domains, structures, and/or functions, and do not consider the heterogeneous relationships of the proteins. In this work, we present KSFinder, a tool that predicts kinase-substrate links by captu
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Cozza, G., F. Meggio, and S. Moro. "The Dark Side of Protein Kinase CK2 Inhibition." Current Medicinal Chemistry 18, no. 19 (2011): 2867–84. http://dx.doi.org/10.2174/092986711796150423.

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Salcedo, Mariah V., Nathan Gravel, Abbas Keshavarzi, Liang-Chin Huang, Krzysztof J. Kochut, and Natarajan Kannan. "Predicting protein and pathway associations for understudied dark kinases using pattern-constrained knowledge graph embedding." PeerJ 11 (October 18, 2023): e15815. http://dx.doi.org/10.7717/peerj.15815.

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The 534 protein kinases encoded in the human genome constitute a large druggable class of proteins that include both well-studied and understudied “dark” members. Accurate prediction of dark kinase functions is a major bioinformatics challenge. Here, we employ a graph mining approach that uses the evolutionary and functional context encoded in knowledge graphs (KGs) to predict protein and pathway associations for understudied kinases. We propose a new scalable graph embedding approach, RegPattern2Vec, which employs regular pattern constrained random walks to sample diverse aspects of node cont
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Weiss, Ellen. "Shedding light on dark adaptation." Biochemist 42, no. 5 (2020): 44–50. http://dx.doi.org/10.1042/bio20200067.

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The retina is famous for its ability to operate under a broad range of light intensities. This is partly due to the presence of two types of photoreceptor cells, rods and cones. Rods are used mostly for dim light vision, and cones are used for bright light and colour vision. These cells are also able to adapt to a broad range of light intensities using light- and dark-adaptation mechanisms. Dark adaptation is used by the vertebrate retina to increase its visual sensitivity when moving from a brightly lit environment to a dark environment. The brighter the surrounding light, the longer it takes
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Tesis sobre el tema "Dark kinase"

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McAloon, L. "Illuminating the Regulation of the Dark Kinase PSKH1." Phd thesis, Australian Catholic University, 2024. https://acuresearchbank.acu.edu.au/download/ddf9adef5f561e344249d40d56e53b20134e8ba28236ce76842a3f1e4e995190/13285318/McAloon_2024_Illuminating_the_regulation_of_the_dark.pdf.

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PSKH1 is a 48 kDa serine/threonine-protein kinase whose function, regulation and downstream effectors remain undefined. Discovered in the late 1980’s, PSKH1 is increasingly implicated in an appreciating number of cellular processes, including vesicle trafficking, cell migration, and pre-mRNA splicing. More recently, PSKH1 was classified as a top-6 driver of prostate cancer progression. Precisely how PSKH1 mediates these effects is not currently understood. This thesis sought to resolve these questions using a combination of in vitro and in vivo experimental methodologies. Chapter 3 details
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Lin, Yao. "Control of DAPK-1 degradation." Thesis, University of Edinburgh, 2009. http://hdl.handle.net/1842/4189.

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DAPK-1 is calcium-calmodulin regulated protein kinase involved in multiple cellular pathways including apoptosis, autophagy, cell survival and motility. The cytokine TNF-α has been reported to induce the degradation of DAPK-1. Here I identified the protease cathepsin B as a novel binding partner of DAPK-1 that protects DAPK-1 from TNF-α induced degradation. Using deletion mutants of DAPK-1, I mapped the cathepsin B binding domain on DAPK-1 to amino acids 836-947. Overexpression of this mini-protein DAPK-1(836-947) facilitated degradation of full-length DAPK-1 and apoptosis induced by TNFR-1. M
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Lorén, Christina. "Investigating the function of the Receptor Tyrosine Kinase ALK during Drosophila melanogaster development." Doctoral thesis, Umeå universitet, Umeå centrum för molekylär patogenes (UCMP), 2004. http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-411.

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The Drosophila melanogaster gene Anaplastic Lymphoma Kinase (DAlk) is homologous to mammalian Alk, which is a member of the Alk/Ltk family of receptor tyrosine kinases (RTKs). In humans the t(2;5) translocation involving the Alk locus encodes an active form of Alk that is the causative agent in Non-Hodgkin’s Lymphoma (Morris et al., 1994). Alk has also been associated with other cancers such as inflammatory myofibroblastic tumours (IMTs). The physiological function of the Alk RTK has not been described in any system until very recently, and is still not defined in vertebrates. The molecular si
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Yang, Lei. "Structural studies on human dihydroxyacetone kinase (DAK) and the carbohydrate-binding domain of Streptococcus pneumoniae NanA." Thesis, University of St Andrews, 2013. http://hdl.handle.net/10023/4506.

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A number of dihydroxyacetone kinases (DAK) have been described that can utilize either ATP (in animals, plants and some bacteria) or phosphoenolpyruvate (PEP) (in most bacteria) as the energy source to convert dihydroxyacetone (Dha) to dihydroxyacetone phosphate (DhaP), which plays critical roles in many metabolic pathways. It has also been described that Homo sapiens DAK is able to regulate the innate immune system via its interaction with Melanoma differentiation-associated protein 5 (MDA5), which is recognized as an RNA sensor during virus infection. These findings make H. sapiens DAK a ver
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Vaultier, Marie-Noëlle. "Etude de la perception et de la transduction du signal froid chez Arabidopsis thaliana : Implication des voies de signalisation lipidique." Paris 6, 2006. http://www.theses.fr/2006PA066223.

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Keitz, Fabienne Dominique von [Verfasser], Christian [Akademischer Betreuer] Peschel, and Gisela [Akademischer Betreuer] Keller. "Die Koexpression von Aurora A Kinase und EGFR ist prognostisch für Patienten mit Plattenepithelkarzinomen des Kopf- Hals- Bereichs und stellt eine Zielstruktur für die Therapie dar / Fabienne Dominique von Keitz. Gutachter: Gisela Keller ; Christian Peschel. Betreuer: Christian Peschel." München : Universitätsbibliothek der TU München, 2014. http://d-nb.info/1058434632/34.

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Kongs, Veronica Louise. "Graduate band conducting recital : lesson plans and theoretical/historical analysis of literature." Manhattan, Kan. : Kansas State University, 2007. http://hdl.handle.net/2097/365.

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Furlong, Pierce James. "Aspects of ancient Near Eastern chronology (c. 1600-700 BC)." Melbourne, 2007. http://repository.unimelb.edu.au/10187/2096.

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The chronology of the Late Bronze and Early Iron Age Near East is currently a topic of intense scholarly debate. The conventional/orthodox chronology for this period has been assembled over the past one-two centuries using information from King-lists, royal annals and administrative documents, primarily those from the Great Kingdoms of Egypt, Assyria and Babylonia. This major enterprise has resulted in what can best be described as an extremely complex but little understood jigsaw puzzle composed of a multiplicity of loosely connected data. I argue in my thesis that this conventional chronolog
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Weraduwage, Sarathi. "Harnessing the anabolic properties of dark respiration to enhance sink activity at elevated CO2 using Arabidopsis thaliana L. with partially-suppressed mitochondrial pyruvate dehydrogenase kinase." Thesis, 2013. http://hdl.handle.net/10214/6759.

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Sink limitations in plants reduce the potential for photosynthesis and yield, particularly under conditions that favour enhanced source activity such as elevated CO2 (EC). Dark respiration, considered catabolic, has rarely been exploited to enhance sink activity in plants. Arabidopsis thaliana L. lines with partially-suppressed mitochondrial pyruvate dehydrogenase (mtPDH) kinase (mtPDHK), a negative post-translational regulator of the mtPDH complex, was shown previously to have both elevated mtPDH complex activity and increased seed weight and oil content at ambient CO2 (AC), suggesting an enh
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Widau, Ryan Cole. "Protein phosphatase 2A (PP2A) holoenzymes regulate death associated protein kinase (DAPK) in ceramide-induced anoikis." Thesis, 2010. http://hdl.handle.net/1805/2131.

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Indiana University-Purdue University Indianapolis (IUPUI)<br>Modulation of sphingolipid-induced apoptosis is a potential mechanism to enhance the effectiveness of chemotherapeutic drugs. Ceramide is a pleiotropic, sphingolipid produced by cells in response to inflammatory cytokines, chemotherapeutic drugs and ionizing radiation. Ceramide is a potent activator of protein phosphatases, including protein phosphatase 2A (PP2A) leading to dephosphorylation of substrates important in regulating mitochondrial dysfunction and apoptosis. Previous studies demonstrated that death associated protein kinas
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Libros sobre el tema "Dark kinase"

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Gemmell, David. Dark prince. Ballantine Books, 1991.

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Gemmell, David. Dark prince. Ballantine Books, 1993.

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Gemmell, David. Dark prince. Century, 1991.

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Inc, Mada Design, ed. The Dark Fortress. Scholastic, 2005.

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Duhig, Ian. The speed of dark. Picador, 2007.

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Shreeve, Nicholas. Dark legacy: The fortunes of Begam Samru. Rupa & Co., 1998.

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Koen, Karleen. Dark angels: A novel. Crown, 2006.

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Koen, Karleen. Dark angels: A novel. Random House Large Print, 2006.

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Indonesia, Persekutuan Gereja-Gereja di. Dari Kinasih ke Mamasa: Sebuah catatan perjalanan pelayanan PGI masa bakti 2004-2009. Persekutuan Gereja-Gereja di Indonesia, 2009.

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John, Judith. A dark history : Tudors: Murder, adultery, incest, witchcraft, wars, religious persecution, piracy. Metro Books, 2014.

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Capítulos de libros sobre el tema "Dark kinase"

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Vener, A. V., P. J. M. van Kan, A. Gal, I. Ohad, and B. Andersson. "Reversible Activation of LHCII Kinase by Transient Low pH Treatment of Thylakoids in the Dark." In Photosynthesis: from Light to Biosphere. Springer Netherlands, 1995. http://dx.doi.org/10.1007/978-94-009-0173-5_363.

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Peters, H. "Magen-Darm-Trakt." In Die Ultraschalluntersuchung des Kindes. Springer Berlin Heidelberg, 1997. http://dx.doi.org/10.1007/978-3-642-59139-6_11.

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Légeret, Corinne, and Margarete Bolten. "Materialien zur Diagnostik bei funktionellen Magen-Darm-Störungen." In Funktionelle Magen-Darm-Störungen im Kindes- und Jugendalter. Springer Berlin Heidelberg, 2022. http://dx.doi.org/10.1007/978-3-662-64253-5_8.

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Bolten, Margarete, and Corinne Légeret. "Materialien zur interdisziplinären Behandlung bei funktionellen Magen-Darm-Störungen." In Funktionelle Magen-Darm-Störungen im Kindes- und Jugendalter. Springer Berlin Heidelberg, 2022. http://dx.doi.org/10.1007/978-3-662-64253-5_9.

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Légeret, Corinne, and Margarete Bolten. "Pathogenese funktioneller gastrointestinaler Störungen." In Funktionelle Magen-Darm-Störungen im Kindes- und Jugendalter. Springer Berlin Heidelberg, 2022. http://dx.doi.org/10.1007/978-3-662-64253-5_5.

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Légeret, Corinne, and Margarete Bolten. "Klinische Symptomatik und Klassifikation funktioneller gastrointestinaler Störungen im Kindes- und Jugendalter." In Funktionelle Magen-Darm-Störungen im Kindes- und Jugendalter. Springer Berlin Heidelberg, 2022. http://dx.doi.org/10.1007/978-3-662-64253-5_4.

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Bolten, Margarete, and Corinne Légeret. "Therapieansätze bei funktionellen gastrointestinalen Störungen." In Funktionelle Magen-Darm-Störungen im Kindes- und Jugendalter. Springer Berlin Heidelberg, 2022. http://dx.doi.org/10.1007/978-3-662-64253-5_7.

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Légeret, Corinne, and Margarete Bolten. "Diagnostik und Differenzialdiagnostik bei funktionellen Darmstörungen." In Funktionelle Magen-Darm-Störungen im Kindes- und Jugendalter. Springer Berlin Heidelberg, 2022. http://dx.doi.org/10.1007/978-3-662-64253-5_6.

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Bolten, Margarete. "Die Sauberkeitsentwicklung im Kindesalter." In Funktionelle Magen-Darm-Störungen im Kindes- und Jugendalter. Springer Berlin Heidelberg, 2022. http://dx.doi.org/10.1007/978-3-662-64253-5_3.

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Bolten, Margarete. "Psychosoziale Aspekte der Nahrungsaufnahme, Verdauung und Ausscheidung." In Funktionelle Magen-Darm-Störungen im Kindes- und Jugendalter. Springer Berlin Heidelberg, 2022. http://dx.doi.org/10.1007/978-3-662-64253-5_2.

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Actas de conferencias sobre el tema "Dark kinase"

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Essegian, Derek J., Rimpi Khurana, Vasileios Stathias, Valery Chavez, Jaime R. Merchan, and Stephan Schürer. "Abstract 5103: The dark cancer kinome - untapped opportunities for the development of novel drugs." In Proceedings: AACR Annual Meeting 2019; March 29-April 3, 2019; Atlanta, GA. American Association for Cancer Research, 2019. http://dx.doi.org/10.1158/1538-7445.sabcs18-5103.

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Essegian, Derek J., Rimpi Khurana, Vasileios Stathias, Valery Chavez, Jaime R. Merchan, and Stephan Schürer. "Abstract 5103: The dark cancer kinome - untapped opportunities for the development of novel drugs." In Proceedings: AACR Annual Meeting 2019; March 29-April 3, 2019; Atlanta, GA. American Association for Cancer Research, 2019. http://dx.doi.org/10.1158/1538-7445.am2019-5103.

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Mejtoft, Thomas, Erik Frängsmyr, Ulrik Söderström, and Ole Norberg. "Deceptive Design: Cookie Consent and Manipulative Patterns." In Digital Support from Crisis to Progressive Change. University of Maribor Press, 2021. http://dx.doi.org/10.18690/978-961-286-485-9.29.

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As a larger proportion of our lives moves onto the web, so does important and valuable information. This has led to an increase in different kinds of manipulative patterns (dark patterns) in web design with the sole purpose of being deceptive and tricking users. This paper discusses the comprehensive suite of deceptive design patterns on Internet services where the users are expected to comply with the use of cookies. This was done by analyzing 50 different home cooking recipe websites, regarding their appliance to GDPR and how they use different dark patterns in their design. Even though legi
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F., Adolfo, and Licoa C. "Digital Cultures of Horror in Mónica Ojeda’s Fiction." In XII Congress of the ICLA. Georgian Comparative Literature Association, 2025. https://doi.org/10.62119/icla.4.9051.

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The Internet is a world where all kinds of people with different interests, motivations, and worldviews browse and interact with each other. These interactions have given rise to diverse digital cultures, some of which can be called Digital Cultures of Horror. As an inhabitant of the contempo­rary world, Mónica Ojeda is aware of these cultures’ dark themes and envi­ronments and how they shape the lives of their members, so she has used them to create her fiction and depicts the dreadful side of human beings. Mónica Ojeda describes the horrors of the Internet and digital cultures in her novels
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Xu, Shou-long, and Shu-liang Zou. "Video Monitoring System Availability in Radiation Accident Condition." In 2016 24th International Conference on Nuclear Engineering. American Society of Mechanical Engineers, 2016. http://dx.doi.org/10.1115/icone24-60848.

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Study of availability in radiation environment is presented for video monitoring system. Testing experiment has been completed by seven kinds of Image sensor module which includes three kinds of digital image sensor module and four kinds of analog image sensor module. Radiation accident condition was simulated by γ-ray ionizing radiation environment where the dose rate at 16.63Gy/h 20.20Gy/h and 58.30Gy/h. Availability has been studied by analyzing real time monitoring image quality parameters captured in γ-ray exposure environment. The primary image quality parameters include average gray lev
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Furuya, Yoshiyuki, Saburo Matsuoka, and Takayuki Abe. "Frequency Effects on Gigacycle Fatigue Properties of High-Strength Steels." In ASME/JSME 2004 Pressure Vessels and Piping Conference. ASMEDC, 2004. http://dx.doi.org/10.1115/pvp2004-2986.

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This report will reveal a series of fatigue test results for high-strength steels at 100 Hz and 20 kHz and discuss frequency effects on gigacycle fatigue properties. The 20 kHz fatigue testing machine is an effective tool to conduct gigacycle fatigue tests in a reasonable term, while frequency effects have to be carefully investigated before applying the machine. The fatigue tests were conducted for two kinds of high-strength steels, that were a low-alloy steel and a spring steel. These fatigue test results showed that the frequency effects were negligible even at 20 kHz in case of fish-eye fr
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Ciolan, Laura elena. "DIGIKIDS: TECHNOLOGY MEDIATED DEVELOPMENT, BEYOND FEAR AND STEREOTYPES." In eLSE 2012. Editura Universitara, 2012. http://dx.doi.org/10.12753/2066-026x-12-075.

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The social and pedagogical discourse about ”digital natives”, Millennials, or ”digikids” is not so new anymore, but as the case with many serious, even dramatic changes, a whole range of stereotypes and prejudices developed concerning this new generation, seriously affecting he quality of interaction with adults in general, and the quality of educational interaction in particular. We will try in this paper to look the the learning characteristics of the new generation of kids, as well as on their consequences in designing learning experiences. Quality of the new generations is not intrinsic, n
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Chi Hsu, Ying, I. Wen Yen, and Meng-Cong Zheng. "Knowledge Visualization of Earthquake: Impact of Design Format on Readers' Perception and Understanding." In 14th International Conference on Applied Human Factors and Ergonomics (AHFE 2023). AHFE International, 2023. http://dx.doi.org/10.54941/ahfe1003221.

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To strengthen the seismic intensity and differentiate adaptations to earthquakes in Taiwan, the Central Weather Bureau of the Ministry of Transportation and Communications subdivided the original seismic intensity of 5 Strong and 6 Violent earthquakes of the Seismic Intensity Scale into 5 Lower and 5 Upper, 6 Lower and 6 Upper respectively in 2020.First, we collected 28 infographics from domestic and overseas governmental and private institutions and stock image websites using earthquake intensity as the keyword. Three researchers with design backgrounds classified the infographics into three
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Vanegas Luna, Laura. "El juego como re-significador de la circunstancia y la ciudad." In Seminario Internacional de Investigación en Urbanismo. Universidad Piloto de Colombia, 2022. http://dx.doi.org/10.5821/siiu.10461.

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Play, understood as a social activity practiced by humans, takes place in its own kind of place: the playspace. This text finds itself on the premise that play allows players to understand and use an environment in new and unforeseen ways, assigning new meanings and interpretations to the city and said environment. Thus, this text supports itself on the study of games performed in public spaces, a hide-and-seek session and conversations held with Pokémon Go users. Taking these studies into account, unique and different kinds of living and experiencing a place during a play session can be ident
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Informes sobre el tema "Dark kinase"

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Lers, Amnon, and Gan Susheng. Study of the regulatory mechanism involved in dark-induced Postharvest leaf senescence. United States Department of Agriculture, 2009. http://dx.doi.org/10.32747/2009.7591734.bard.

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Postharvest leaf senescence contributes to quality losses in flowers and leafy vegetables. The general goal of this research project was to investigate the regulatory mechanisms involved in dark-induced leaf senescence. The regulatory system involved in senescence induction and control is highly complex and possibly involves a network of senescence promoting pathways responsible for activation of the senescence-associated genes. Pathways involving different internal signals and environmental factors may have distinctive importance in different leaf senescence systems. Darkness is known to have
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Chamovitz, Daniel, and Albrecht Von Arnim. Translational regulation and light signal transduction in plants: the link between eIF3 and the COP9 signalosome. United States Department of Agriculture, 2006. http://dx.doi.org/10.32747/2006.7696515.bard.

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The COP9 signalosome (CSN) is an eight-subunit protein complex that is highly conserved among eukaryotes. Genetic analysis of the signalosome in the plant model species Arabidopsis thaliana has shown that the signalosome is a repressor of light dependent seedling development as mutant Arabidopsis seedlings that lack this complex develop in complete darkness as if exposed to light. These mutant plants die following the seedling stage, even when exposed to light, indicating that the COP9 signalosome also has a central role in the regulation of normal photomorphogenic development. The biochemical
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3

Meyer, Erik. Night skies data report: Photometric assessment of night sky quality at Sequoia and Kings Canyon National Parks. National Park Service, 2025. https://doi.org/10.36967/2308859.

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This report characterizes night sky conditions in Sequoia and Kings Canyon National Parks (SEKI) using measurements made in the park unit and models of regional conditions based on satellite data. Calibrated night sky imagery was obtained to characterize the night sky at 5 sites. These ground-based observations were collected on 8 nights from 2004-06-12 to 2009-07-21. Satellite data from 2022 was used to create a map of predicted night sky conditions in and around the park. The sky overhead remains pristine with an average zenith brightness of 21.63 mag/arcsec2. We estimate more than 91% of st
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