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Artículos de revistas sobre el tema "Dendrite differentiation"

Autor: Grafiati

Publicado: 4 de junio de 2021

Última modificación: 14 de febrero de 2022

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1

Sharp, David J., Wenqian Yu, Lotfi Ferhat, Ryoko Kuriyama, David C. Rueger, and Peter W. Baas. "Identification of a Microtubule-associated Motor Protein Essential for Dendritic Differentiation." Journal of Cell Biology 138, no. 4 (1997): 833–43. http://dx.doi.org/10.1083/jcb.138.4.833.

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The quintessential feature of the dendritic microtubule array is its nonuniform pattern of polarity orientation. During the development of the dendrite, a population of plus end–distal microtubules first appears, and these microtubules are subsequently joined by a population of oppositely oriented microtubules. Studies from our laboratory indicate that the latter microtubules are intercalated within the microtubule array by their specific transport from the cell body of the neuron during a critical stage in development (Sharp, D.J., W. Yu, and P.W. Baas. 1995. J. Cell Biol. 130:93– 104). In ad

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2

Takano, Tetsuya, Tomoki Urushibara, Nozomu Yoshioka, et al. "LMTK1 regulates dendritic formation by regulating movement of Rab11A-positive endosomes." Molecular Biology of the Cell 25, no. 11 (2014): 1755–68. http://dx.doi.org/10.1091/mbc.e14-01-0675.

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Neurons extend two types of neurites—axons and dendrites—that differ in structure and function. Although it is well understood that the cytoskeleton plays a pivotal role in neurite differentiation and extension, the mechanisms by which membrane components are supplied to growing axons or dendrites is largely unknown. We previously reported that the membrane supply to axons is regulated by lemur kinase 1 (LMTK1) through Rab11A-positive endosomes. Here we investigate the role of LMTK1 in dendrite formation. Down-regulation of LMTK1 increases dendrite growth and branching of cerebral cortical neu

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3

Sharp, D. J., W. Yu, and P. W. Baas. "Transport of dendritic microtubules establishes their nonuniform polarity orientation." Journal of Cell Biology 130, no. 1 (1995): 93–103. http://dx.doi.org/10.1083/jcb.130.1.93.

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The immature processes that give rise to both axons and dendrites contain microtubules (MTs) that are uniformly oriented with their plus-ends distal to the cell body, and this pattern is preserved in the developing axon. In contrast, developing dendrites gradually acquire nonuniform MT polarity orientation due to the addition of a subpopulation of oppositely oriented MTs (Baas, P. W., M. M. Black, and G. A. Banker. 1989. J. Cell Biol. 109:3085-3094). In theory, these minus-end-distal MTs could be locally nucleated and assembled within the dendrite itself, or could be transported into the dendr

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4

Yu, Wenqian, David J. Sharp, Ryoko Kuriyama, Prabhat Mallik, and Peter W. Baas. "Inhibition of a Mitotic Motor Compromises the Formation of Dendrite-like Processes from Neuroblastoma Cells." Journal of Cell Biology 136, no. 3 (1997): 659–68. http://dx.doi.org/10.1083/jcb.136.3.659.

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Microtubules in the axon are uniformly oriented, while microtubules in the dendrite are nonuniformly oriented. We have proposed that these distinct microtubule polarity patterns may arise from a redistribution of molecular motor proteins previously used for mitosis of the developing neuroblast. To address this issue, we performed studies on neuroblastoma cells that undergo mitosis but also generate short processes during interphase. Some of these processes are similar to axons with regard to their morphology and microtubule polarity pattern, while others are similar to dendrites. Treatment wit

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5

Yoong, Li-Foong, Yun-Jin Pai, and Adrian W. Moore. "Stages and transitions in dendrite arbor differentiation." Neuroscience Research 138 (January 2019): 70–78. http://dx.doi.org/10.1016/j.neures.2018.09.015.

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6

Tanaka, Makito, Tetsuro Sasada, Tetsuya Nakamoto, et al. "Immunogenicity of Artificial Dendritic Cells Is Upregulated by ROCK Inhibition-Mediated Dendrite Formation." Blood 114, no. 22 (2009): 3022. http://dx.doi.org/10.1182/blood.v114.22.3022.3022.

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Abstract Abstract 3022 Poster Board II-998 Dendritic cells (DC) are “professional” antigen-presenting cells (APC) that can prime T cells. Their characteristic morphology and phenotype segregate them from other APC. Many studies suggest that mature DC are able to induce potent antitumor T cell immunity that can reject tumors. Based on this, numerous cancer vaccine trials using ex vivo generated DC have been conducted in humans. However, the observed objective response rates in these studies have been disappointing. This could partially be attributed to difficulties in generating large numbers o

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7

Abdelmohsen, Kotb, Emmette R. Hutchison, Eun Kyung Lee, et al. "miR-375 Inhibits Differentiation of Neurites by Lowering HuD Levels." Molecular and Cellular Biology 30, no. 17 (2010): 4197–210. http://dx.doi.org/10.1128/mcb.00316-10.

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ABSTRACT Neuronal development and plasticity are maintained by tightly regulated gene expression programs. Here, we report that the developmentally regulated microRNA miR-375 affects dendrite formation and maintenance. miR-375 overexpression in mouse hippocampus potently reduced dendrite density. We identified the predominantly neuronal RNA-binding protein HuD as a key effector of miR-375 influence on dendrite maintenance. Heterologous reporter analysis verified that miR-375 repressed HuD expression through a specific, evolutionarily conserved site on the HuD 3′ untranslated region. miR-375 ov

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8

Chamak, B., and A. Prochiantz. "Influence of extracellular matrix proteins on the expression of neuronal polarity." Development 106, no. 3 (1989): 483–91. http://dx.doi.org/10.1242/dev.106.3.483.

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The influence of laminin (LN) and fibronectin (FN) on the differentiation of individual neurones from the embryonic rat central nervous system was studied in vitro. In control cultures or in the presence of soluble FN, most neurones had several dendrite-like and one axon-like processes. On substratum-bound LN, multipolar and unipolar cells were present. Soluble LN and bound FN induced a very simple neuronal morphology, most neurones having only one axon-like neurite as defined by morphological and immunocytochemical characteristics. The significant reduction of neuronal adhesion and spreading

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9

Buscà, Roser, Corine Bertolotto, Patricia Abbe, et al. "Inhibition of Rho Is Required for cAMP-induced Melanoma Cell Differentiation." Molecular Biology of the Cell 9, no. 6 (1998): 1367–78. http://dx.doi.org/10.1091/mbc.9.6.1367.

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Up-regulation of the cAMP pathway by forskolin or α-melanocyte stimulating hormone induces melanocyte and melanoma cell differentiation characterized by stimulation of melanin synthesis and dendrite development. Here we show that forskolin-induced dendricity is associated to a disassembly of actin stress fibers. Since Rho controls actin organization, we studied the role of this guanosine triphosphate (GTP)-binding protein in cAMP-induced dendrite formation.Clostridium botulinum C3 exotransferase, which inhibits Rho, mimicked the effect of forskolin in promoting dendricity and stress fiber disr

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10

Baudouin, Stéphane J., Julie Angibaud, Gildas Loussouarn та ін. "The Signaling Adaptor Protein CD3ζ Is a Negative Regulator of Dendrite Development in Young Neurons". Molecular Biology of the Cell 19, № 6 (2008): 2444–56. http://dx.doi.org/10.1091/mbc.e07-09-0947.

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A novel idea is emergxsing that a large molecular repertoire is common to the nervous and immune systems, which might reflect the existence of novel neuronal functions for immune molecules in the brain. Here, we show that the transmembrane adaptor signaling protein CD3ζ, first described in the immune system, has a previously uncharacterized role in regulating neuronal development. Biochemical and immunohistochemical analyses of the rat brain and cultured neurons showed that CD3ζ is mainly expressed in neurons. Distribution of CD3ζ in developing cultured hippocampal neurons, as determined by im

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11

Ruan, Zhi Yi, Sheng Da Zeng, Li Xin Lin, and Lu Rong Wu. "Phase Field Method Simulation of Dendrite Crystal Growth of Metal Nickel Based on Fractal Theory." Applied Mechanics and Materials 190-191 (July 2012): 522–27. http://dx.doi.org/10.4028/www.scientific.net/amm.190-191.522.

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Using fractal theory simulation of dendrite crystal DLA growth model of pure substance, the undercooling during solidification process of crystal nucleation is simulated; and then in the crystal nuclei are formed on the basis of a pure substance, the phase field model and combined with the finite difference method further differentiation simulation of dendrite crystal growth. According to MATLAB programming, the simulation results obtained by field and temperature field can be seen in the DLA growth, growth model with random premise, for the same kind of material simulated dendrite crystal hav

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12

Zhang, Keqin, Cielo Barragan-Adjemian, Ling Ye, et al. "E11/gp38 Selective Expression in Osteocytes: Regulation by Mechanical Strain and Role in Dendrite Elongation." Molecular and Cellular Biology 26, no. 12 (2006): 4539–52. http://dx.doi.org/10.1128/mcb.02120-05.

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ABSTRACT Within mineralized bone, osteocytes form dendritic processes that travel through canaliculi to make contact with other osteocytes and cells on the bone surface. This three-dimensional syncytium is thought to be necessary to maintain viability, cell-to-cell communication, and mechanosensation. E11/gp38 is the earliest osteocyte-selective protein to be expressed as the osteoblast differentiates into an osteoid cell or osteocyte, first appearing on the forming dendritic processes of these cells. Bone extracts contain large amounts of E11, but immunostaining only shows its presence in ear

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13

Serdar, Mordelt, Müser, et al. "Detrimental Impact of Energy Drink Compounds on Developing Oligodendrocytes and Neurons." Cells 8, no. 11 (2019): 1381. http://dx.doi.org/10.3390/cells8111381.

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The consumption of energy drinks is continuously rising, particularly in children and adolescents. While risks for adverse health effects, like arrhythmia, have been described, effects on neural cells remain elusive. Considering that neurodevelopmental processes like myelination and neuronal network formation peak in childhood and adolescence we hypothesized that developing oligodendrocytes and neurons are particularly vulnerable to main energy drink components. Immature oligodendrocytes and hippocampal neurons were isolated from P0-P1 Wistar rats and were incubated with 0.3 mg/mL caffeine and

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14

Podkowa, Monika, Xin Zhao, Chi-Wing Chow, Eleanor T. Coffey, Roger J. Davis, and Liliana Attisano. "Microtubule Stabilization by Bone Morphogenetic Protein Receptor-Mediated Scaffolding of c-Jun N-Terminal Kinase Promotes Dendrite Formation." Molecular and Cellular Biology 30, no. 9 (2010): 2241–50. http://dx.doi.org/10.1128/mcb.01166-09.

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ABSTRACT Neuronal outgrowth occurs via coordinated remodeling of the cytoskeleton involving both actin and microtubules. Microtubule stabilization drives the extending neurite, yet little is known of the molecular mechanisms whereby extracellular cues regulate microtubule dynamics. Bone morphogenetic proteins (BMPs) play an important role in neuronal differentiation and morphogenesis, and BMP7 in particular induces the formation of dendrites. Here, we show that BMP7 induces stabilization of microtubules in both a MAP2-dependent neuronal cell culture model and in dendrites of primary cortical n

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15

He, Chun-Wei, Chien-Po Liao, and Chun-Liang Pan. "Wnt signalling in the development of axon, dendrites and synapses." Open Biology 8, no. 10 (2018): 180116. http://dx.doi.org/10.1098/rsob.180116.

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Wnts are a highly conserved family of secreted glycoproteins that play essential roles in the morphogenesis and body patterning during the development of metazoan species. In recent years, mounting evidence has revealed important functions of Wnt signalling in diverse aspects of neural development, including neuronal polarization, guidance and branching of the axon and dendrites, as well as synapse formation and its structural remodelling. In contrast to Wnt signalling in cell proliferation and differentiation, which mostly acts through β-catenin-dependent pathways, Wnts engage a diverse array

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16

Lieven, Christopher J., Lucia E. Millet, Mark J. Hoegger, and Leonard A. Levin. "Induction of axon and dendrite formation during early RGC-5 cell differentiation." Experimental Eye Research 85, no. 5 (2007): 678–83. http://dx.doi.org/10.1016/j.exer.2007.08.001.

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17

Kawada, Koichi, Takaaki Iekumo, Ryo Saito, et al. "Aberrant neuronal differentiation and inhibition of dendrite outgrowth resulting from endoplasmic reticulum stress." Journal of Neuroscience Research 92, no. 9 (2014): 1122–33. http://dx.doi.org/10.1002/jnr.23389.

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18

Nakanishi, Keiko, Hiroyuki Niida, Hidenori Tabata, et al. "Isozyme-Specific Role of SAD-A in Neuronal Migration During Development of Cerebral Cortex." Cerebral Cortex 29, no. 9 (2018): 3738–51. http://dx.doi.org/10.1093/cercor/bhy253.

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Abstract SAD kinases regulate presynaptic vesicle clustering and neuronal polarization. A previous report demonstrated that Sada−/− and Sadb−/− double-mutant mice showed perinatal lethality with a severe defect in axon/dendrite differentiation, but their single mutants did not. These results indicated that they were functionally redundant. Surprisingly, we show that on a C57BL/6N background, SAD-A is essential for cortical development whereas SAD-B is dispensable. Sada−/− mice died within a few days after birth. Their cortical lamination pattern was disorganized and radial migration of cortica

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19

Osorio, C., P. J. Chacon, L. Kisiswa, et al. "Growth differentiation factor 5 is a key physiological regulator of dendrite growth during development." Development 140, no. 23 (2013): 4751–62. http://dx.doi.org/10.1242/dev.101378.

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20

HARTENSTEIN, VOLKER. "Development of Drosophila larval sensory organs: spatiotemporal pattern of sensory neurones, peripheral axonal pathways and sensilla differentiation." Development 102, no. 4 (1988): 869–86. http://dx.doi.org/10.1242/dev.102.4.869.

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The sensilla of Drosophila larval thoracic and abdominal segments appear in a constant temporal sequence during stage 13/14 (9·5–11·5 h) of embryonic development. Those sensilla innervated by more than one dendrite (basiconical sensilla, chordotonal organs, some of the trichoid sensilla and campaniform sensilla) appear earlier than sensilla innervated by a single dendrite (majority of trichoid sensilla and campaniform sensilla). Furthermore, a dorsoventrally directed gradient underlies the sequence in which sensilla of a given type appear. Sensory axons are emitted in the same sequence. Thus,

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21

Jung, Seunghyun, Nathaniel Harris, Isabelle I. Niyonshuti, et al. "Photothermal Response Induced by Nanocage-Coated Artificial Extracellular Matrix Promotes Neural Stem Cell Differentiation." Nanomaterials 11, no. 5 (2021): 1216. http://dx.doi.org/10.3390/nano11051216.

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Strategies to increase the proportion of neural stem cells that differentiate into neurons are vital for therapy of neurodegenerative disorders. In vitro, the extracellular matrix composition and topography have been found to be important factors in stem cell differentiation. We have developed a novel artificial extracellular matrix (aECM) formed by attaching gold nanocages (AuNCs) to glass coverslips. After culturing rat neural stem cells (rNSCs) on these gold nanocage-coated surfaces (AuNC-aECMs), we observed that 44.6% of rNSCs differentiated into neurons compared to only 27.9% for cells gr

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22

Chernousov, A. D., M. F. Nikonova, N. I. Sharova, et al. "Neolactoferrin As a Stimulator of Innate and Adaptive Immunity." Acta Naturae 5, no. 4 (2013): 71–76. http://dx.doi.org/10.32607/20758251-2013-5-4-71-76.

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The effect of the innovative product Neolactoferrin, a natural combination of recombinant human lactoferrin (90%) and goat lactoferrin (10%) isolated from the milk of transgenic goats carrying the full-length human lactoferrin gene, on human immune system cells was studied. Neolactoferrin enhanced the production of IL-1. Neolactoferrin saturated with iron ions increased the synthesis of pro-inflammatory cytokine TNF. It determined the direction of the differentiation of precursor dendrite cells. Under the action of T cells, Neolactoferrin amplified the expression of the transcription factors r

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23

Ka, Minhan, and Woo-Yang Kim. "ANKRD11 associated with intellectual disability and autism regulates dendrite differentiation via the BDNF/TrkB signaling pathway." Neurobiology of Disease 111 (March 2018): 138–52. http://dx.doi.org/10.1016/j.nbd.2017.12.008.

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24

Barbon, Silvia, Senthilkumar Rajendran, Thomas Bertalot, et al. "Growth and Differentiation of Circulating Stem Cells After Extensive Ex Vivo Expansion." Tissue Engineering and Regenerative Medicine 18, no. 3 (2021): 411–27. http://dx.doi.org/10.1007/s13770-021-00330-7.

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Abstract Background: Stem cell therapy is gaining momentum as an effective treatment strategy for degenerative diseases. Adult stem cells isolated from various sources (i.e., cord blood, bone marrow, adipose tissue) are being considered as a realistic option due to their well-documented therapeutic potentials. Our previous studies standardized a method to isolate circulating multipotent cells (CMCs) that are able to sustain long term in vitro culture and differentiate towards mesodermal lineages. Methods: In this work, long-term cultures of CMCs were stimulated to study in vitro neuronal and m

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25

Urbaniak, Lech. "Morphometric differentiation of Corex ligerica Gay in Poland." Acta Societatis Botanicorum Poloniae 67, no. 3-4 (2014): 263–68. http://dx.doi.org/10.5586/asbp.1998.034.

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The experimental material involved 7 <em>Carex ligerica</em> Gay populations which were cultured in standardised conditions in a greenhouse before their spikes were collected for morphological studies. Four characters reflecting size of male and female glumes, selected from particular spikes were examined. Mahalanobis distances for each pair of populations were calculated and their significance was estimated using Hotellings T<sup>2</sup> statistics. Dendrite was constructed on the basis of shortest Mahalanobis distances while Euclidean distances provided grounds for hi

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26

Paulin, Joshua J. W., Peter Haslehurst, Alexander D. Fellows, et al. "Large and Small Dendritic Spines Serve Different Interacting Functions in Hippocampal Synaptic Plasticity and Homeostasis." Neural Plasticity 2016 (2016): 1–11. http://dx.doi.org/10.1155/2016/6170509.

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The laying down of memory requires strong stimulation resulting in specific changes in synaptic strength and corresponding changes in size of dendritic spines. Strong stimuli can also be pathological, causing a homeostatic response, depressing and shrinking the synapse to prevent damage from too much Ca2+influx. But do all types of dendritic spines serve both of these apparently opposite functions? Using confocal microscopy in organotypic slices from mice expressing green fluorescent protein in hippocampal neurones, the size of individual spines along sections of dendrite has been tracked in r

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27

Kanao, Shingo, Naomi Ogura, Kosuke Takahashi, et al. "Capacity of Human Dental Follicle Cells to Differentiate into Neural CellsIn Vitro." Stem Cells International 2017 (2017): 1–10. http://dx.doi.org/10.1155/2017/8371326.

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The dental follicle is an ectomesenchymal tissue surrounding the developing tooth germ. Human dental follicle cells (hDFCs) have the capacity to commit to differentiation into multiple cell types. Here we investigated the capacity of hDFCs to differentiate into neural cells and the efficiency of a two-step strategy involving floating neurosphere-like bodies for neural differentiation. Undifferentiated hDFCs showed a spindle-like morphology and were positive for neural markers such as nestin,β-III-tubulin, and S100β. The cellular morphology of several cells was neuronal-like including branched

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28

Dierssen, M., and M. Martínez de Lagrán. "DYRK1A (Dual-Specificity Tyrosine-Phosphorylated and -Regulated Kinase 1A): A Gene with Dosage Effect During Development and Neurogenesis." Scientific World JOURNAL 6 (2006): 1911–22. http://dx.doi.org/10.1100/tsw.2006.319.

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DYRKs (dual-specificity tyrosine-regulated kinases) are an emerging family of evolutionarily conserved dual-specificity kinases that play key roles in cell proliferation, survival, and development. The research in the last years suggests a relevant conserved function during neuronal development, related to proliferation and/or differentiation for DYRK1A. It is expressed in neural progenitor cells and has been proposed to participate in the signaling mechanisms that regulate dendrite differentiation. InDrosophila, disruption of the homologminibraingene results in flies with reduced neuroblast p

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29

Zhao, Lian-mei, Guo-gui Sun, Li-na Han, et al. "P-Hydroxycinnamaldehyde Induces B16-F1 Melanoma Cell Differentiation via the RhoA-MAPK Signaling Pathway." Cellular Physiology and Biochemistry 38, no. 6 (2016): 2247–60. http://dx.doi.org/10.1159/000445580.

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Background/Aims: Due to its antitumor and gastroprotective properties, cochinchina momordica seed (CMS), has been widely used to treat cancer patients in Asia. Our previous reports have shown that CMS is able to induce the differentiation of B16-F1 melanoma cells. However, its functional component and mechanism remain unclear and are addressed in this study. Methods and Results: CMSP (p-hydroxycinnamaldehyde isolated from CMS) inhibited the proliferation, migration and invasiveness of B16-F1 cells both in vivo and in vitro. CMSP also induced the differentiation of B16-F1 cells, as characterize

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30

Duellberg, Christian, Albert Auer, Nikola Canigova, Katrin Loibl, and Martin Loose. "In vitro reconstitution reveals phosphoinositides as cargo-release factors and activators of the ARF6 GAP ADAP1." Proceedings of the National Academy of Sciences 118, no. 1 (2020): e2010054118. http://dx.doi.org/10.1073/pnas.2010054118.

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The differentiation of cells depends on a precise control of their internal organization, which is the result of a complex dynamic interplay between the cytoskeleton, molecular motors, signaling molecules, and membranes. For example, in the developing neuron, the protein ADAP1 (ADP-ribosylation factor GTPase-activating protein [ArfGAP] with dual pleckstrin homology [PH] domains 1) has been suggested to control dendrite branching by regulating the small GTPase ARF6. Together with the motor protein KIF13B, ADAP1 is also thought to mediate delivery of the second messenger phosphatidylinositol (3,

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31

Park, Hyeonseon, Anikó Váradi, Heon Seok, et al. "mGluR5 is involved in dendrite differentiation and excitatory synaptic transmission in NTERA2 human embryonic carcinoma cell-derived neurons." Neuropharmacology 52, no. 6 (2007): 1403–14. http://dx.doi.org/10.1016/j.neuropharm.2007.01.021.

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32

Park, Seyeon, Eun Sook Ahn, and Yunjoo Kim. "Neuroblastoma SH-SY5Y cell-derived exosomes stimulate dendrite-like outgrowths and modify the differentiation of A375 melanoma cells." Cell Biology International 39, no. 4 (2014): 379–87. http://dx.doi.org/10.1002/cbin.10401.

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Ariyani, Winda, Wataru Miyazaki, and Noriyuki Koibuchi. "A Novel Role of Nuclear and Membrane Receptor on Isoflavone-Induced Neuritogenesis and Synaptogenesis." Journal of the Endocrine Society 5, Supplement_1 (2021): A802—A803. http://dx.doi.org/10.1210/jendso/bvab048.1632.

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Abstract Thyroid hormone (TH) receptor (TR) and estrogen receptor (ER) play crucial roles in brain development. TR and ER are involved in dendrite growth, spines, and synapse formation in neurons. Soybean isoflavones, such as genistein, daidzein, and daidzein metabolite, S-equol are known to exert their action through TR, ER, and GPER1, a G-protein-coupled ER. However, the mechanisms of isoflavones action on brain development, especially during neuritogenesis and synaptogenesis, have not yet been extensively studied. We evaluated the effects of isoflavones using mouse primary cerebellar cultur

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34

Bryan, Brad, Vikas Kumar, Lewis Joe Stafford, Yi Cai, Gangyi Wu, and Mingyao Liu. "GEFT, A Rho Family Guanine Nucleotide Exchange Factor, Regulates Neurite Outgrowth and Dendritic Spine Formation." Journal of Biological Chemistry 279, no. 44 (2004): 45824–32. http://dx.doi.org/10.1074/jbc.m406216200.

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The Rho family of small GTPases controls a wide range of cellular processes in eukaryotic cells, such as normal cell growth, proliferation, differentiation, gene regulation, actin cytoskeletal organization, cell fate determination, and neurite outgrowth. The activation of Rho-GTPases requires the exchange of GDP for GTP, a process catalyzed by the Dbl family of guanine nucleotide exchange factors. We demonstrate that a newly identified guanine nucleotide exchange factor, GEFT, is widely expressed in the brain and highly concentrated in the hippocampus, and the Purkinje and granular cells of th

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35

Diez-Guerra, F. Javier, and Jesus Avila. "An Increase in Phosphorylation of Microtubule-associated Protein 2 Accompanies Dendrite Extension During the Differentiation of Cultured Hippocampal Neurones." European Journal of Biochemistry 227, no. 1-2 (1995): 68–77. http://dx.doi.org/10.1111/j.1432-1033.1995.tb20360.x.

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36

Caux, C., C. Massacrier, B. Vanbervliet, et al. "Activation of human dendritic cells through CD40 cross-linking." Journal of Experimental Medicine 180, no. 4 (1994): 1263–72. http://dx.doi.org/10.1084/jem.180.4.1263.

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Dendritic cells, the professional antigen-presenting cells (APC) involved in T cell priming, express CD40, a molecule which triggering plays a key role in B cell growth and differentiation as well as monocyte activation. Herein we demonstrate that dendritic Langerhans cells (D-Lc) generated by culturing cord blood CD34+ progenitor cells with granulocyte/macrophage colony-stimulating and tumor necrosis factor alpha (TNF-alpha) express functional CD40 at a density higher than that found on B cells. Culturing D-Lc on CD40-ligand (CD40L) transfected L cells allowed D-Lc survival as 50 +/- 15% of s

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37

Flann, S., R. B. Hawkes, B. M. Riederer, C. C. Rider, and P. W. Beesley. "Changes in ubiquitin immunoreactivity in developing rat brain: a putative role for ubiquitin and ubiquitin conjugates in dendrite outgrowth and differentiation." Neuroscience 81, no. 1 (1997): 173–87. http://dx.doi.org/10.1016/s0306-4522(97)00196-6.

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Tran, Phu V., Stephanie J. B. Fretham, Jane Wobken, Bradley S. Miller, and Michael K. Georgieff. "Gestational-neonatal iron deficiency suppresses and iron treatment reactivates IGF signaling in developing rat hippocampus." American Journal of Physiology-Endocrinology and Metabolism 302, no. 3 (2012): E316—E324. http://dx.doi.org/10.1152/ajpendo.00369.2011.

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Gestational-neonatal iron deficiency, a common micronutrient deficiency affecting the offspring of more than 30% of pregnancies worldwide, leads to long-term cognitive and behavioral abnormalities. Preclinical models of gestational-neonatal iron deficiency result in reduced energy metabolism and expression of genes critical for neuronal plasticity and cognitive function, which are associated with a smaller hippocampal volume and abnormal neuronal dendrite growth. Because insulin-like growth factor (IGF) modulates early postnatal cellular growth, differentiation, and survival, we used a dietary

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Lafourcade, C. A., T. V. Lin, D. M. Feliciano, L. Zhang, L. S. Hsieh, and A. Bordey. "Rheb Activation in Subventricular Zone Progenitors Leads to Heterotopia, Ectopic Neuronal Differentiation, and Rapamycin-Sensitive Olfactory Micronodules and Dendrite Hypertrophy of Newborn Neurons." Journal of Neuroscience 33, no. 6 (2013): 2419–31. http://dx.doi.org/10.1523/jneurosci.1840-12.2013.

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Fu, Xiuping, Yanrui Yang, Chenchang Xu, et al. "Retrolinkin cooperates with endophilin A1 to mediate BDNF–TrkB early endocytic trafficking and signaling from early endosomes." Molecular Biology of the Cell 22, no. 19 (2011): 3684–98. http://dx.doi.org/10.1091/mbc.e11-04-0308.

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Brain-derived neurotrophic factor (BDNF) binds to its cell surface receptor TrkB to regulate differentiation, development, synaptic plasticity, and functional maintenance of neuronal cells. Binding of BDNF triggers TrkB dimerization and autophosphorylation, which provides docking sites for adaptor proteins to recruit and activate downstream signaling molecules. The molecular mechanisms underlying BDNF–TrkB endocytic trafficking crucial for spatiotemporal control of signaling pathways remain to be elucidated. Here we show that retrolinkin, a transmembrane protein, interacts with endophilin A1 a

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Shibata, A., M. V. Wright, S. David, L. McKerracher, P. E. Braun, and S. B. Kater. "Unique Responses of Differentiating Neuronal Growth Cones to Inhibitory Cues Presented by Oligodendrocytes." Journal of Cell Biology 142, no. 1 (1998): 191–202. http://dx.doi.org/10.1083/jcb.142.1.191.

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During central nervous system development, neurons differentiate distinct axonal and dendritic processes whose outgrowth is influenced by environmental cues. Given the known intrinsic differences between axons and dendrites and that little is known about the response of dendrites to inhibitory cues, we tested the hypothesis that outgrowth of differentiating axons and dendrites of hippocampal neurons is differentially influenced by inhibitory environmental cues. A sensitive growth cone behavior assay was used to assess responses of differentiating axonal and dendritic growth cones to oligodendr

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Ariyani, Winda, Wataru Miyazaki, and Noriyuki Koibuchi. "A Novel Mechanism of S-equol Action in Neurons and Astrocytes: The Possible Involvement of GPR30/GPER1." International Journal of Molecular Sciences 20, no. 20 (2019): 5178. http://dx.doi.org/10.3390/ijms20205178.

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S-equol is a major bacterial metabolite of the soy isoflavone daidzein. It is known to be a phytoestrogen that acts by binding to the nuclear estrogen receptors (ERs) that are expressed in various brain regions, including the cerebellum. However, the effects of S-equol on cerebellar development and function have not yet been extensively studied. In this study, the effects of S-equol were evaluated using a mouse primary cerebellar culture, Neuro-2A clonal cells, and an astrocyte-enriched culture. S-equol augmented the dendrite arborization of Purkinje cells induced by triiodothyronine (T3) and

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Slominski, A., G. Moellmann, and E. Kuklinska. "MSH inhibits growth in a line of amelanotic hamster melanoma cells and induces increases in cyclic AMP levels and tyrosinase activity without inducing melanogenesis." Journal of Cell Science 92, no. 4 (1989): 551–59. http://dx.doi.org/10.1242/jcs.92.4.551.

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In Bomirski Ab amelanotic hamster melanoma cells, L-tyrosine and/or L-dopa induce increases in tyrosinase activity as well as synthesis of melanosomes and melanin. L-tyrosine also modifies melanocyte-stimulating hormone (MSH) binding. In this paper we show that in the Bomirski amelanotic melanoma system MSH and agents that raise intracellular cyclic AMP induce dendrite formation, inhibit cell growth, and cause substantial increases in tyrosinase activity without inducing melanin synthesis. Tyrosinase activity is detected only in broken cell preparations, or cytochemically in fixed cells. In th

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Gurau, Carmela, Gheorghe Gurau, Valentina Mitran, Alexandru Dan, and Anisoara Cimpean. "The Influence of Severe Plastic Deformation on Microstructure and In Vitro Biocompatibility of the New Ti-Nb-Zr-Ta-Fe-O Alloy Composition." Materials 13, no. 21 (2020): 4853. http://dx.doi.org/10.3390/ma13214853.

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In this work, severe plastic deformation (SPD) of the newly designed Ti-Nb-Zr-Ta-Fe-O GUM metal was successfully conducted at room temperature using high speed high pressure torsion (HSHPT) followed by cold rolling (CR) to exploit the suitability of the processed alloy for bone staples. The Ti-31.5Nb-3.1Zr-3.1Ta-0.9Fe-0.16O GUM alloy was fabricated in a levitation melting furnace using a cold crucible and argon protective atmosphere. The as-cast specimens were subjected to SPD, specifically HSHPT, and then processed by the CR method to take the advantages of both grain refinement and larger di

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Allinquant, B., P. Hantraye, P. Mailleux, K. Moya, C. Bouillot, and A. Prochiantz. "Downregulation of amyloid precursor protein inhibits neurite outgrowth in vitro." Journal of Cell Biology 128, no. 5 (1995): 919–27. http://dx.doi.org/10.1083/jcb.128.5.919.

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The amyloid precursor protein (APP) is a transmembrane protein expressed in several cell types. In the nervous system, APP is expressed by glial and neuronal cells, and several lines of evidence suggest that it plays a role in normal and pathological phenomena. To address the question of the actual function of APP in normal developing neurons, we undertook a study aimed at blocking APP expression using antisense oligonucleotides. Oligonucleotide internalization was achieved by linking them to a vector peptide that translocates through biological membranes. This original technique, which is ver

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Jones, Daniel L., MacKenzie A. Howard, Amelia Stanco, John L. R. Rubenstein, and Scott C. Baraban. "Deletion of Dlx1 results in reduced glutamatergic input to hippocampal interneurons." Journal of Neurophysiology 105, no. 5 (2011): 1984–91. http://dx.doi.org/10.1152/jn.00056.2011.

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Dlx transcription factors are important in the differentiation of GABAergic interneurons. In mice lacking Dlx1, early steps in interneuron development appear normal. Beginning at ∼1 mo of age, primarily dendrite-innervating interneuron subtypes begin to undergo apoptosis in Dlx1−/− mice; this is accompanied by a reduction in GABAergic transmission and late-onset epilepsy. The reported reduction of synaptic inhibition is greater than might be expected given that interneuron loss is relatively modest in Dlx1−/− mice. Here we report that voltage-clamp recordings of CA1 interneurons in hippocampal

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Parcerisas, Antoni, Lluís Pujadas, Alba Ortega-Gascó, et al. "NCAM2 Regulates Dendritic and Axonal Differentiation through the Cytoskeletal Proteins MAP2 and 14-3-3." Cerebral Cortex 30, no. 6 (2020): 3781–99. http://dx.doi.org/10.1093/cercor/bhz342.

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Abstract Neural cell adhesion molecule 2 (NCAM2) is involved in the development and plasticity of the olfactory system. Genetic data have implicated the NCAM2 gene in neurodevelopmental disorders including Down syndrome and autism, although its role in cortical development is unknown. Here, we show that while overexpression of NCAM2 in hippocampal neurons leads to minor alterations, its downregulation severely compromises dendritic architecture, leading to an aberrant phenotype including shorter dendritic trees, retraction of dendrites, and emergence of numerous somatic neurites. Further, our

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Chen, Chiung-Ya, Chia-Wen Lin, Chiung-Ying Chang, Si-Tse Jiang, and Yi-Ping Hsueh. "Sarm1, a negative regulator of innate immunity, interacts with syndecan-2 and regulates neuronal morphology." Journal of Cell Biology 193, no. 4 (2011): 769–84. http://dx.doi.org/10.1083/jcb.201008050.

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Dendritic arborization is a critical neuronal differentiation process. Here, we demonstrate that syndecan-2 (Sdc2), a synaptic heparan sulfate proteoglycan that triggers dendritic filopodia and spine formation, regulates dendritic arborization in cultured hippocampal neurons. This process is controlled by sterile α and TIR motif–containing 1 protein (Sarm1), a negative regulator of Toll-like receptor 3 (TLR3) in innate immunity signaling. We show that Sarm1 interacts with and receives signal from Sdc2 and controls dendritic arborization through the MKK4–JNK pathway. In Sarm1 knockdown mice, de

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Tanaka, Masahiko. "The Dendritic Differentiation of Purkinje Neurons: Unsolved Mystery in Formation of Unique Dendrites." Cerebellum 14, no. 3 (2014): 227–30. http://dx.doi.org/10.1007/s12311-014-0585-0.

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Manning, L., and C. Q. Doe. "Prospero distinguishes sibling cell fate without asymmetric localization in the Drosophila adult external sense organ lineage." Development 126, no. 10 (1999): 2063–71. http://dx.doi.org/10.1242/dev.126.10.2063.

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The adult external sense organ precursor (SOP) lineage is a model system for studying asymmetric cell division. Adult SOPs divide asymmetrically to produce IIa and IIb daughter cells; IIa generates the external socket (tormogen) and hair (trichogen) cells, while IIb generates the internal neuron and sheath (thecogen) cells. Here we investigate the expression and function of prospero in the adult SOP lineage. Although Prospero is asymmetrically localized in embryonic SOP lineage, this is not observed in the adult SOP lineage: Prospero is first detected in the IIb nucleus and, during IIb divisio

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