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Artículos de revistas sobre el tema "Determinants and dynamics of infectious diseases"

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Publicado: 7 de julio de 2024

Última modificación: 19 de julio de 2025

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1

LIAO, C. M., S. C. YANG, C. P. CHIO, and S. C. CHEN. "Understanding influenza virus-specific epidemiological properties by analysis of experimental human infections." Epidemiology and Infection 138, no. 6 (2009): 825–35. http://dx.doi.org/10.1017/s0950268809991178.

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SUMMARYThis study aimed to estimate the natural history and transmission parameters based on experimental viral shedding and symptom dynamics in order to understand the key epidemiological factors that characterize influenza (sub)type epidemics. A simple statistical algorithm was developed by combining a well-defined mathematical scheme of epidemiological determinants and experimental human influenza infection. Here we showed that (i) the observed viral shedding dynamics mapped successfully the estimated time-profile of infectiousness and (ii) the profile of asymptomatic probability was obtain

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2

Grant, Andrew J., Gemma L. Foster, Trevelyan J. McKinley, et al. "Bacterial Growth Rate and Host Factors as Determinants of Intracellular Bacterial Distributions in Systemic Salmonella enterica Infections." Infection and Immunity 77, no. 12 (2009): 5608–11. http://dx.doi.org/10.1128/iai.00827-09.

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ABSTRACT Bacteria of the species Salmonella enterica cause a range of life-threatening diseases in humans and animals worldwide. The within-host quantitative, spatial, and temporal dynamics of S. enterica interactions are key to understanding how immunity acts on these infections and how bacteria evade immune surveillance. In this study, we test hypotheses generated from mathematical models of in vivo dynamics of Salmonella infections with experimental observation of bacteria at the single-cell level in infected mouse organs to improve our understanding of the dynamic interactions between host

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3

Fibriansah, Guntur, Xin-Ni Lim, and Shee-Mei Lok. "Morphological Diversity and Dynamics of Dengue Virus Affecting Antigenicity." Viruses 13, no. 8 (2021): 1446. http://dx.doi.org/10.3390/v13081446.

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The four serotypes of the mature dengue virus can display different morphologies, including the compact spherical, the bumpy spherical and the non-spherical clubshape morphologies. In addition, the maturation process of dengue virus is inefficient and therefore some partially immature dengue virus particles have been observed and they are infectious. All these viral particles have different antigenicity profiles and thus may affect the type of the elicited antibodies during an immune response. Understanding the molecular determinants and environmental conditions (e.g., temperature) in inducing

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4

Duan, Xujie, Rui Liu, Wenjing Lan, and Shuying Liu. "The Essential Role of Mitochondrial Dynamics in Viral Infections." International Journal of Molecular Sciences 26, no. 5 (2025): 1955. https://doi.org/10.3390/ijms26051955.

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Mitochondria are dynamic organelles that play crucial roles in energy production, metabolic balance, calcium homeostasis, apoptosis, and innate immunity, and are key determinants of cell fate. They are also targets for viral invasion of the body. Many viral proteins target mitochondria, controlling mitochondrial morphology, metabolism, and immune response, thereby achieving immune evasion, promoting their proliferation, and accelerating the infection process. Mitochondrial quality control is key to maintaining normal physiological functions and mitochondrial homeostasis. Dysregulation of mitoc

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5

Quaglia, Agustin I., Erik M. Blosser, Bethany L. McGregor, et al. "Tracking Community Timing: Pattern and Determinants of Seasonality in Culicoides (Diptera: Ceratopogonidae) in Northern Florida." Viruses 12, no. 9 (2020): 931. http://dx.doi.org/10.3390/v12090931.

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Community dynamics are embedded in hierarchical spatial–temporal scales that connect environmental drivers with species assembly processes. Culicoides species are hematophagous arthropod vectors of orbiviruses that impact wild and domestic ruminants. A better sense of Culicoides dynamics over time is important because sympatric species can lengthen the seasonality of virus transmission. We tested a putative departure from the four seasons calendar in the phenology of Culicoides and the vector subassemblage in the Florida panhandle. Two years of weekly abundance data, temporal scales, persisten

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METCALF, C. J. E., O. N. BJØRNSTAD, M. J. FERRARI, et al. "The epidemiology of rubella in Mexico: seasonality, stochasticity and regional variation." Epidemiology and Infection 139, no. 7 (2010): 1029–38. http://dx.doi.org/10.1017/s0950268810002165.

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SUMMARYThe factors underlying the temporal dynamics of rubella outside of Europe and North America are not well known. Here we used 20 years of incidence reports from Mexico to identify variation in seasonal forcing and magnitude of transmission across the country and to explore determinants of inter-annual variability in epidemic magnitude in rubella. We found considerable regional variation in both magnitude of transmission and amplitude of seasonal variation in transmission. Several lines of evidence pointed to stochastic dynamics as an important driver of multi-annual cycles. Since average

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7

Chukwuma Sr, Chrysanthus. "Features of the Emergence and Re-Emergence of Infectious Diseases, Geopolitics and Gain-of-Function Research." International Journal of Coronaviruses 3, no. 4 (2022): 10–18. http://dx.doi.org/10.14302/issn.2692-1537.ijcv-21-4044.

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This paper attempts to present the dissemination and transmission dynamics of emerging and reemerging infectious diseases and the underlying features of gain-of-function research and geopolitics in the ambient within and across borders. Research and publication are relevant from perspectives in the management of local and global health because disease is perspicuously a geopolitical issue ostensibly linked to gain-of-function research where health diplomacy undergirds present and future global functionalities regarding the emergence and reemergence of infectious diseases. These have generated

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8

Chrysanthus, Chukwuma Sr. "Geopolitical issues in health and biosecurity concerning gain-of-function research, emergence and re-emergence of infectious diseases." International Journal of Clinical Virology 6, no. 1 (2022): 011–16. http://dx.doi.org/10.29328/journal.ijcv.1001043.

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There are global concerns in the dissemination and transmission dynamics of emerging and reemerging infectious diseases and the underlying features of gain-of-function research and geopolitics within and across borders. These concerns have become pertinent in the management of local and global health because the disease is perspicuously a geopolitical issue ostensibly linked to gain-of-function research where health diplomacy focuses on the present and future global emergence and re-emergence of infectious diseases, pandemics, and microbiome variants. These have generated vehement reactions wi

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9

Sr, Dr Chrysanthus Chukwuma. "Perspectives in the Emergence and Re-Emergence of Infectious Diseases, Geopolitics and Gain-of-Function Research." Scholars International Journal of Biochemistry 5, no. 1 (2022): 1–7. http://dx.doi.org/10.36348/sijb.2022.v05i01.001.

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This paper attempts to present the dissemination and transmission dynamics of emerging and reemerging infectious diseases and the underlying features of gain-of-function research and geopolitics in the ambient within and across borders. Research and publication are relevant from perspectives in the management of local and global health because disease is perspicuously a geopolitical issue ostensibly linked to gain-of-function research where health diplomacy undergirds present and future global functionalities regarding the emergence and reemergence of infectious diseases. These have generated

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10

Myall, A., I. Venkatachalam, C. Philip, et al. "SPATIAL-TEMPORAL DETERMINANTS OF MDRO TRANSMISSION DYNAMICS: IMPLICATIONS FOR INFECTION CONTROL." International Journal of Infectious Diseases 130 (May 2023): S31. http://dx.doi.org/10.1016/j.ijid.2023.04.071.

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11

Pereira, Felicidade Mota, Aline Salomão de Araujo, Ana Catarina Martins Reis, et al. "Dynamics and Determinants of SARS-CoV-2 RT-PCR Testing on Symptomatic Individuals Attending Healthcare Centers during 2020 in Bahia, Brazil." Viruses 14, no. 7 (2022): 1549. http://dx.doi.org/10.3390/v14071549.

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RT-PCR testing data provides opportunities to explore regional and individual determinants of test positivity and surveillance infrastructure. Using Generalized Additive Models, we explored 222,515 tests of a random sample of individuals with COVID-19 compatible symptoms in the Brazilian state of Bahia during 2020. We found that age and male gender were the most significant determinants of test positivity. There was evidence of an unequal impact among socio-demographic strata, with higher positivity among those living in areas with low education levels during the first epidemic wave, followed

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12

Verkade, Erwin, Birgit van Benthem, Marjolein Kluytmans-van den Bergh, et al. "Dynamics and Determinants of Staphylococcus aureus Carriage in Livestock Veterinarians: A Prospective Cohort Study." Clinical Infectious Diseases 57, no. 2 (2013): e11-e17. http://dx.doi.org/10.1093/cid/cit228.

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13

DE MELKER, H. E., and M. A. E. CONYN-VAN SPAENDONCK. "Immunosurveillance and the evaluation of national immunization programmes: a population-based approach." Epidemiology and Infection 121, no. 3 (1998): 637–43. http://dx.doi.org/10.1017/s0950268898001587.

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Mass vaccination can change the epidemiological dynamics of infectious diseases. It may result in a limited persistence of natural and vaccine-induced immunity and a higher mean age of infection, which may lead to a greater risk of complications. The epidemiological situation should be monitored and immunosurveillance based on the assessment of specific antibodies against vaccine-preventable diseases in human serum is one of the tools. In order to estimate the immunity of the Dutch population reliably, a large-scale, population-based, collection of serum samples was established (8359 sera in a

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14

Lambrechts, Louis, Robert C. Reiner, M. Veronica Briesemeister, et al. "Direct mosquito feedings on dengue-2 virus-infected people reveal dynamics of human infectiousness." PLOS Neglected Tropical Diseases 17, no. 9 (2023): e0011593. http://dx.doi.org/10.1371/journal.pntd.0011593.

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Dengue virus (DENV) transmission from humans to mosquitoes is a poorly documented, but critical component of DENV epidemiology. Magnitude of viremia is the primary determinant of successful human-to-mosquito DENV transmission. People with the same level of viremia, however, can vary in their infectiousness to mosquitoes as a function of other factors that remain to be elucidated. Here, we report on a field-based study in the city of Iquitos, Peru, where we conducted direct mosquito feedings on people naturally infected with DENV and that experienced mild illness. We also enrolled people natura

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15

Ntajal, Joshua, Timo Falkenberg, Thomas Kistemann, and Mariele Evers. "Influences of Land-Use Dynamics and Surface Water Systems Interactions on Water-Related Infectious Diseases—A Systematic Review." Water 12, no. 3 (2020): 631. http://dx.doi.org/10.3390/w12030631.

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Human interactions with surface water systems, through land-use dynamics, can influence the transmission of infectious water-related diseases. As a result, the aim of our study was to explore and examine the state of scientific evidence on the influences of these interactions on water-related infectious disease outcomes from a global perspective. A systematic review was conducted, using 54 peer-reviewed research articles published between 1995 and August 2019. The study revealed that there has been an increase in the number of publications since 2009; however, few of these publications (n = 6)

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16

Boyd, Patricia S., Janae B. Brown, Joshua D. Brown, et al. "NMR Studies of Retroviral Genome Packaging." Viruses 12, no. 10 (2020): 1115. http://dx.doi.org/10.3390/v12101115.

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Nearly all retroviruses selectively package two copies of their unspliced RNA genomes from a cellular milieu that contains a substantial excess of non-viral and spliced viral RNAs. Over the past four decades, combinations of genetic experiments, phylogenetic analyses, nucleotide accessibility mapping, in silico RNA structure predictions, and biophysical experiments were employed to understand how retroviral genomes are selected for packaging. Genetic studies provided early clues regarding the protein and RNA elements required for packaging, and nucleotide accessibility mapping experiments prov

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17

Charuni, T. M. J. "Narrative review on the spectrum of diseases prevalent among substance-addicted populations and their interconnected health dynamics." Journal of Science of the University of Kelaniya 17, no. 1 (2024): 57–63. http://dx.doi.org/10.4038/josuk.v17i1.8107.

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Substance addiction is a complex phenomenon characterized by the dysfunction of the brain's reward system and neuroplasticity, leading individuals to lose control over their behaviour. This review explores the diverse health implications of addiction, including its impact on liver diseases, cardiovascular conditions, respiratory issues, cancers, infectious diseases, gastrointestinal problems, and mental disorders. Heavy alcohol consumption, tobacco use, illicit drug abuse, and prescription drug misuse contribute significantly to these health burdens, affecting various organs and systems in the

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18

CHANG, M., S. L. GROSECLOSE, A. A. ZAIDI, and C. R. BRADEN. "An ecological analysis of sociodemographic factors associated with the incidence of salmonellosis, shigellosis, and E. coli O157:H7 infections in US counties." Epidemiology and Infection 137, no. 6 (2008): 810–20. http://dx.doi.org/10.1017/s0950268808001477.

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SUMMARYIdentifying county-level sociodemographic and economic factors associated with the incidence of enteric disease may provide new insights concerning the dynamics of community transmission of these diseases as well as opportunities for prevention. We used data from the National Notifiable Diseases Surveillance System, the U.S. Census Bureau, and the Health Resources and Services Administration to conduct an ecological analysis of 26 sociodemographic and economic factors associated with the incidence of salmonellosis, shigellosis, and E. coli O157:H7 infections in US counties for the perio

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19

Hounkonnou, Cornélia P. A., Valérie Briand, Nadine Fievet, et al. "Dynamics of Submicroscopic Plasmodium falciparum Infections Throughout Pregnancy: A Preconception Cohort Study in Benin." Clinical Infectious Diseases 71, no. 1 (2019): 166–74. http://dx.doi.org/10.1093/cid/ciz748.

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Abstract Background In the context of global malaria elimination efforts, special attention is being paid to submicroscopic Plasmodium falciparum infections. In pregnant, sub-Saharan African women, such infections are more prevalent than microscopic infections, and are thought to have adverse effects on both mothers’ and newborns’ health. However, no study has studied the dynamics and determinants of these infections throughout pregnancy. Retard de Croissance Intra-uterin et Paludisme (RECIPAL), a preconception cohort study carried out in Benin between 2014 and 2017, represented a unique oppor

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20

Mironova, L. V., A. S. Ponomareva, E. A. Basov та ін. "Assessing the Efciency of Detection of Vibrio cholerae Genetic Determinants Through Waterbody Vibrioﬂora Monitoring System". Problems of Particularly Dangerous Infections, № 3 (23 жовтня 2021): 89–97. http://dx.doi.org/10.21055/0370-1069-2021-3-89-97.

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Objective of the study was to assess the eﬀectiveness of PCR screening of Vibrio cholerae genetic determinants in samples from surface water reservoirs for optimization of the cholera microbiological monitoring system.Materials and methods. The study was carried out as a part of the vibrioﬂora monitoring in surface water bodies in Irkutsk city. The study design included: 1) PCR screening of V. cholerae genetic determinants in nutrient-enriched (1 % peptone water) samples from surface water reservoirs during the monitoring period (824 samples); 2) studying of the V. cholerae DNA accumulation dy

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21

Lourenço, José, and Mario Recker. "Viral and Epidemiological Determinants of the Invasion Dynamics of Novel Dengue Genotypes." PLoS Neglected Tropical Diseases 4, no. 11 (2010): e894. http://dx.doi.org/10.1371/journal.pntd.0000894.

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22

Ding, Wandi, Yun Kang, and Anuj Mubayi. "Special Issue: Mathematical modeling and analysis of social and ecological determinants for the dynamics of infectious diseases and public health policies." Mathematical Biosciences and Engineering 18, no. 6 (2021): 8535–37. http://dx.doi.org/10.3934/mbe.2021422.

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23

Fabre, Frédéric, Claude Bruchou, Alain Palloix, and Benoît Moury. "Key determinants of resistance durability to plant viruses: Insights from a model linking within- and between-host dynamics." Virus Research 141, no. 2 (2009): 140–49. http://dx.doi.org/10.1016/j.virusres.2008.11.021.

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24

Snyman, Albert, Ralph Eric Thijl Vanstreels, Chandré Nell, et al. "Determinants of external and blood parasite load in African penguins (Spheniscus demersus) admitted for rehabilitation." Parasitology 147, no. 5 (2020): 577–83. http://dx.doi.org/10.1017/s0031182020000141.

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AbstractWe investigate the factors associated with the occurrence and abundance of external and blood parasites in African penguins (Spheniscus demersus), an endangered seabird that breeds exclusively on the coasts of Namibia and South Africa. External parasites were collected using the dust-ruffling method from 171 African Penguins admitted at a rehabilitation facility in the Western Cape, South Africa. Additionally, blood smears were obtained upon admission and weekly during rehabilitation and examined for blood parasites. Fleas Parapsyllus longicornis humboldti, ticks Ornithodoros capensis

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25

Segundo Salej Higgins, Sílvio, Adrian Pablo Hinojosa Luna, Reinaldo Onofre dos Santos, Andreia Maria Pinto Rabelo, Maíra Soalheiro, and Vanessa Cardoso Ferreira. "A study on social contact rates relevant for the spread of infectious diseases in a Brazilian slum." Revista Brasileira de Estudos de População 40 (August 11, 2023): 1–20. http://dx.doi.org/10.20947/s0102-3098a0241.

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Inspired by the POLYMOD study, an epidemiological survey was conducted in June 2021 in one of the most densely populated and socially vulnerable sectors of Belo Horizonte (Brazil). A sample of 1000 individuals allowed us to identify, within a 24-hour period, the rates of social contacts by age groups, the size and frequency of clique in which respondents participated, as well as other associated sociodemographic factors (number of household residents, location of contact, use of public transportation, among others). Data were analyzed in two phases. In the first one, results between two SIR mo

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Bernhauerová, Veronika, Veronica V. Rezelj, and Marco Vignuzzi. "Modelling Degradation and Replication Kinetics of the Zika Virus In Vitro Infection." Viruses 12, no. 5 (2020): 547. http://dx.doi.org/10.3390/v12050547.

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Mathematical models of in vitro viral kinetics help us understand and quantify the main determinants underlying the virus–host cell interactions. We aimed to provide a numerical characterization of the Zika virus (ZIKV) in vitro infection kinetics, an arthropod-borne emerging virus that has gained public recognition due to its association with microcephaly in newborns. The mathematical model of in vitro viral infection typically assumes that degradation of extracellular infectious virus proceeds in an exponential manner, that is, each viral particle has the same probability of losing infectivi

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27

Farooq, Tahir, Muhammad Dilshad Hussain, Muhammad Taimoor Shakeel, et al. "Deploying Viruses against Phytobacteria: Potential Use of Phage Cocktails as a Multifaceted Approach to Combat Resistant Bacterial Plant Pathogens." Viruses 14, no. 2 (2022): 171. http://dx.doi.org/10.3390/v14020171.

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Plants in nature are under the persistent intimidation of severe microbial diseases, threatening a sustainable food production system. Plant-bacterial pathogens are a major concern in the contemporary era, resulting in reduced plant growth and productivity. Plant antibiotics and chemical-based bactericides have been extensively used to evade plant bacterial diseases. To counteract this pressure, bacteria have evolved an array of resistance mechanisms, including innate and adaptive immune systems. The emergence of resistant bacteria and detrimental consequences of antimicrobial compounds on the

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Al-Neama, Raed Taha, Kevin J. Bown, Damer P. Blake, and Richard J. Birtles. "Determinants of Eimeria and Campylobacter infection dynamics in UK domestic sheep: the role of co-infection." Parasitology 148, no. 5 (2021): 623–29. http://dx.doi.org/10.1017/s0031182021000044.

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Luz, Saturnino, and Masood Masoodian. "Exploring Environmental and Geographical Factors Influencing the Spread of Infectious Diseases with Interactive Maps." Sustainability 14, no. 16 (2022): 9990. http://dx.doi.org/10.3390/su14169990.

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Environmental problems due to human activities such as deforestation, urbanisation, and large scale intensive farming are some of the major factors behind the rapid spread of many infectious diseases. This in turn poses significant challenges not only in as regards providing adequate healthcare, but also in supporting healthcare workers, medical researchers, policy makers, and others involved in managing infectious diseases. These challenges include surveillance, tracking of infections, communication of public health knowledge and promotion of behavioural change. Behind these challenges lies a

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Churakov, Mikhail, Christian J. Villabona-Arenas, Moritz U. G. Kraemer, Henrik Salje, and Simon Cauchemez. "Spatio-temporal dynamics of dengue in Brazil: Seasonal travelling waves and determinants of regional synchrony." PLOS Neglected Tropical Diseases 13, no. 4 (2019): e0007012. http://dx.doi.org/10.1371/journal.pntd.0007012.

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Wang, Zhe, Lu Liu, Liang Shi, et al. "Identifying the Determinants of Distribution of Oncomelania hupensis Based on Geographically and Temporally Weighted Regression Model along the Yangtze River in China." Pathogens 11, no. 9 (2022): 970. http://dx.doi.org/10.3390/pathogens11090970.

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Background: As the unique intermediate host of Schistosoma japonicum, the geographical distribution of Oncomelania hupensis (O. hupensis) is an important index in the schistosomiasis surveillance system. This study comprehensively analyzed the pattern of snail distribution along the Yangtze River in Jiangsu Province and identified the dynamic determinants of the distribution of O. hupensis. Methods: Snail data from 2017 to 2021 in three cities (Nanjing, Zhenjiang, and Yangzhou) along the Yangtze River were obtained from the annual cross-sectional survey produced by the Jiangsu Institute of Par

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32

Chen, Huanhuan, Guangshuo Zhang, Guiling Ding, et al. "Interspecific Host Variation and Biotic Interactions Drive Pathogen Community Assembly in Chinese Bumblebees." Insects 14, no. 11 (2023): 887. http://dx.doi.org/10.3390/insects14110887.

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Bumblebees have been considered one of the most important pollinators on the planet. However, recent reports of bumblebee decline have raised concern about a significant threat to ecosystem stability. Infectious diseases caused by multiple pathogen infections have been increasingly recognized as an important mechanism behind this decline worldwide. Understanding the determining factors that influence the assembly and composition of pathogen communities among bumblebees can provide important implications for predicting infectious disease dynamics and making effective conservation policies. Here

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Davis, E. L., J. Prada, L. J. Reimer, and T. D. Hollingsworth. "Modelling the Impact of Vector Control on Lymphatic Filariasis Programs: Current Approaches and Limitations." Clinical Infectious Diseases 72, Supplement_3 (2021): S152—S157. http://dx.doi.org/10.1093/cid/ciab191.

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Abstract Vector control is widely considered an important tool for lymphatic filariasis (LF) elimination but is not usually included in program budgets and has often been secondary to other policy questions in modelling studies. Evidence from the field demonstrates that vector control can have a large impact on program outcomes and even halt transmission entirely, but implementation is expensive. Models of LF have the potential to inform where and when resources should be focused, but often simplify vector dynamics and focus on capturing human prevalence trends, making them comparatively ill-d

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Pikuła, Anna, Anna Lisowska, and Katarzyna Domańska-Blicharz. "Epidemiology of Infectious Bursal Disease Virus in Poland during 2016–2022." Viruses 15, no. 2 (2023): 289. http://dx.doi.org/10.3390/v15020289.

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Infectious bursal disease virus is an immunosuppressive ubiquitous pathogen that causes serious economic losses in poultry production. The virus is prone to genetic changes through mutations and reassortment, which drive the emergence of new variants and lead to a change in the epidemiological situation in a field. Such a situation is currently being reported due to a large wave of IBDV A3B1 reassortant infections in northwestern Europe. On the other hand, in Poland, which is the largest producer of chicken meat in the EU, the IBDVs of genotypes A3B2 and A3B4 were circulating just before the e

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Lamouroux, David, Jan Nagler, Theo Geisel, and Stephan Eule. "Paradoxical effects of coupling infectious livestock populations and imposing transport restrictions." Proceedings of the Royal Society B: Biological Sciences 282, no. 1800 (2015): 20142805. http://dx.doi.org/10.1098/rspb.2014.2805.

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Spatial heterogeneity of a host population of mobile agents has been shown to be a crucial determinant of many aspects of disease dynamics, ranging from the proliferation of diseases to their persistence and to vaccination strategies. In addition, the importance of regional and structural differences grows in our modern world. Little is known, though, about the consequences when traits of a disease vary regionally. In this paper, we study the effect of a spatially varying per capita infection rate on the behaviour of livestock diseases. We show that the prevalence of an infectious livestock di

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OGDEN, N. H., M. BIGRAS-POULIN, C. J. O'CALLAGHAN, et al. "Vector seasonality, host infection dynamics and fitness of pathogens transmitted by the tickIxodes scapularis." Parasitology 134, no. 2 (2006): 209–27. http://dx.doi.org/10.1017/s0031182006001417.

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Fitness of tick-borne pathogens may be determined by the degree to which their infection dynamics in vertebrate hosts permits transmission cycles if infective and uninfected tick stages are active at different times of the year. To investigate this hypothesis we developed a simulation model that integrates the transmission pattern imposed by seasonally asynchronous nymphal and larvalIxodes scapularisticks in northeastern North America, with a model of infection in white-footed mice (Peromyscus leucopus) reservoir hosts, using the bacteriaBorrelia burgdorferiandAnaplasma phagocytophilumas examp

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Hancke, Diego, and Olga Virginia Suárez. "Factors Affecting Helminth Abundances in Synanthropic Rodents of an Urban Environment." Open Parasitology Journal 6, no. 1 (2018): 87–95. http://dx.doi.org/10.2174/1874421401806010087.

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Background: Current levels of urbanization cause changes in the ecology of hosts, the pathogens, or both, promoting the proliferation of zoonotic diseases. Rodents are a good biological model for the development of pathogen transmission models because it presence is often related to a none-adequate environmental management. Objective: The main goal of this paper was to study the changes in the abundance of helminth populations in synanthropic rodents of an urban landscape. Methods: A total of 92 R. norvegicus and 65 M. musculus were captured in the City of Buenos Aires (Argentina) and were scr

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Fawzy, Mohamed, and Yosra A. Helmy. "The One Health Approach is Necessary for the Control of Rift Valley Fever Infections in Egypt: A Comprehensive Review." Viruses 11, no. 2 (2019): 139. http://dx.doi.org/10.3390/v11020139.

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Rift Valley fever (RVF) is an emerging transboundary, mosquito-borne, zoonotic viral disease caused high morbidity and mortality in both human and ruminant populations. It is considered an important threat to both agriculture and public health in African and the Middle Eastern countries including Egypt. Five major RVF epidemics have been reported in Egypt (1977, 1993, 1994, 1997, and 2003). The virus is transmitted in Egypt by different mosquito's genera such as Aedes, Culex, Anopheles, and Mansonia, leading to abortions in susceptible animal hosts especially sheep, goat, cattle, and buffaloes

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Mohanty, Pratap C., and Kamal Sharma. "Households’ responses on medical pluralism: Dynamics and determinants of access to traditional medicines in India." Clinical Epidemiology and Global Health 12 (October 2021): 100880. http://dx.doi.org/10.1016/j.cegh.2021.100880.

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Kibibi, Wairimu H. "Epidemiology of Anaemia in Children under Five in Uganda: Current Trends, Challenges, and Strategic Approaches." RESEARCH INVENTION JOURNAL OF SCIENTIFIC AND EXPERIMENTAL SCIENCES 4, no. 1 (2024): 17–23. http://dx.doi.org/10.59298/rijses/2024/411723.

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Anaemia in children under five years old is a significant public health issue in Uganda, affecting over half of the vulnerable population and posing challenges to their health and development. The issue is influenced by nutritional deficiencies, infectious diseases, socioeconomic factors, and limited healthcare access. Clinical manifestations include pallor, fatigue, and developmental delays, and early detection is difficult due to non-specific symptoms, resource constraints, and cultural practices. The impact of anaemia on child health and development is profound, affecting physical growth, c

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Sun, Qinfang, Avik Biswas, Dmitry Lyumkis, Ronald Levy, and Nanjie Deng. "Elucidating the Molecular Determinants of the Binding Modes of a Third-Generation HIV-1 Integrase Strand Transfer Inhibitor: The Importance of Side Chain and Solvent Reorganization." Viruses 16, no. 1 (2024): 76. http://dx.doi.org/10.3390/v16010076.

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The first- and second-generation clinically used HIV-1 integrase (IN) strand transfer inhibitors (INSTIs) are key components of antiretroviral therapy (ART), which work by blocking the integration step in the HIV-1 replication cycle that is catalyzed by a nucleoprotein assembly called an intasome. However, resistance to even the latest clinically used INSTIs is beginning to emerge. Developmental third-generation INSTIs, based on naphthyridine scaffolds, are promising candidates to combat drug-resistant viral variants. Among these novel INSTIs, compound 4f exhibits two distinct conformations wh

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42

Banerjee, Soumya, Alan S. Perelson, and Melanie Moses. "Modelling the effects of phylogeny and body size on within-host pathogen replication and immune response." Journal of The Royal Society Interface 14, no. 136 (2017): 20170479. http://dx.doi.org/10.1098/rsif.2017.0479.

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Understanding how quickly pathogens replicate and how quickly the immune system responds is important for predicting the epidemic spread of emerging pathogens. Host body size, through its correlation with metabolic rates, is theoretically predicted to impact pathogen replication rates and immune system response rates. Here, we use mathematical models of viral time courses from multiple species of birds infected by a generalist pathogen (West Nile Virus; WNV) to test more thoroughly how disease progression and immune response depend on mass and host phylogeny. We use hierarchical Bayesian model

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Bbosa, Nicholas, Deogratius Ssemwanga, Rebecca N. Nsubuga, et al. "Phylogenetic Networks and Parameters Inferred from HIV Nucleotide Sequences of High-Risk and General Population Groups in Uganda: Implications for Epidemic Control." Viruses 13, no. 6 (2021): 970. http://dx.doi.org/10.3390/v13060970.

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Phylogenetic inference is useful in characterising HIV transmission networks and assessing where prevention is likely to have the greatest impact. However, estimating parameters that influence the network structure is still scarce, but important in evaluating determinants of HIV spread. We analyzed 2017 HIV pol sequences (728 Lake Victoria fisherfolk communities (FFCs), 592 female sex workers (FSWs) and 697 general population (GP)) to identify transmission networks on Maximum Likelihood (ML) phylogenetic trees and refined them using time-resolved phylogenies. Network generative models were fit

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Cruz-Alegría, Ingrid Yazmin, Nancy Gabriela Santos-Hernández, Christian Ruiz-Castillejos, et al. "Ecoepidemiology of Chagas Disease in a Biological Corridor in Southeastern Mexico: A Promising Approach to Understand the Risk of Chagas Disease." Journal of Parasitology Research 2024 (March 8, 2024): 1–9. http://dx.doi.org/10.1155/2024/4775361.

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Ecoepidemiology is an emerging field that attempts to explain how biotic, environmental, and even social factors influence the dynamics of infectious diseases. Particularly in vector-borne diseases, the study under this approach offers us an overview of the pathogens, vectors, and hosts that coexist in a given region and their ecological determinants. As a result of this, risk predictions can be established in a changing environment and how it may impact human populations. This paper is aimed at evaluating some ecoepidemiological characteristics of Chagas disease in a natural reserve in southe

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Liu, Yang, Sebastian Funk, and Stefan Flasche. "The contribution of pre-symptomatic infection to the transmission dynamics of COVID-2019." Wellcome Open Research 5 (April 1, 2020): 58. http://dx.doi.org/10.12688/wellcomeopenres.15788.1.

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Background: Pre-symptomatic transmission can be a key determinant of the effectiveness of containment and mitigation strategies for infectious diseases, particularly if interventions rely on syndromic case finding. For COVID-19, infections in the absence of apparent symptoms have been reported frequently alongside circumstantial evidence for asymptomatic or pre-symptomatic transmission. We estimated the potential contribution of pre-symptomatic cases to COVID-19 transmission. Methods: Using the probability for symptom onset on a given day inferred from the incubation period, we attributed the

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Ranjan, Amit, Sabiha Shaik, Agnismita Mondal та ін. "Molecular Epidemiology and Genome Dynamics of New Delhi Metallo-β-Lactamase-Producing Extraintestinal Pathogenic Escherichia coli Strains from India". Antimicrobial Agents and Chemotherapy 60, № 11 (2016): 6795–805. http://dx.doi.org/10.1128/aac.01345-16.

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ABSTRACTThe global dissemination and increasing incidence of carbapenem-resistant, Gram-negative organisms have resulted in acute public health concerns. Here, we present a retrospective multicenter study on molecular characterization of metallo-β-lactamase (MBL)-producing clinicalEscherichia coliisolates recovered from extraintestinal infections in two hospitals in Pune, India. We screened a large sample size of 510E. coliisolates for MBL production wherein we profiled their molecular determinants, antimicrobial resistance phenotypes, functional virulence properties, genomic features, and tra

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Kizy, Anne E., and Melody N. Neely. "First Streptococcus pyogenes Signature-Tagged Mutagenesis Screen Identifies Novel Virulence Determinants." Infection and Immunity 77, no. 5 (2009): 1854–65. http://dx.doi.org/10.1128/iai.01306-08.

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ABSTRACT The virulence of bacterial pathogens is a complex process that requires the dynamic expression of many genes for the pathogens to invade and circumvent host defenses, as well as to proliferate in vivo. In this study, we employed a large-scale screen, signature-tagged mutagenesis (STM), to identify Streptococcus pyogenes virulence genes important for pathogenesis within the host. Approximately 1,200 STM mutants were created and screened using the zebrafish infectious disease model. The transposon insertion site was identified for 29 of the 150 mutants that were considered attenuated fo

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Adams, Mark D., E. Ricky Chan, Neil D. Molyneaux, and Robert A. Bonomo. "Genomewide Analysis of Divergence of Antibiotic Resistance Determinants in Closely Related Isolates of Acinetobacter baumannii." Antimicrobial Agents and Chemotherapy 54, no. 9 (2010): 3569–77. http://dx.doi.org/10.1128/aac.00057-10.

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ABSTRACT Multidrug resistance has emerged as a significant concern with infections caused by Acinetobacter baumannii. Ample evidence supports the involvement of mobile genetic elements in the transfer of antibiotic resistance genes, but the extent of variability and the rate of genetic change associated with the acquisition of antibiotic resistance have not been studied in detail. Whole-genome sequence analysis of six closely related clinical isolates of A. baumannii, including four from the same hospital, revealed extensive divergence of the resistance genotype that correlated with observed d

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Robert, Elodie, Manuela Grippa, Dayangnéwendé Edwige Nikiema, et al. "Environmental determinants of E. coli, link with the diarrheal diseases, and indication of vulnerability criteria in tropical West Africa (Kapore, Burkina Faso)." PLOS Neglected Tropical Diseases 15, no. 8 (2021): e0009634. http://dx.doi.org/10.1371/journal.pntd.0009634.

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In 2017, diarrheal diseases were responsible for 606 024 deaths in Sub-Saharan Africa. This situation is due to domestic and recreational use of polluted surface waters, deficits in hygiene, access to healthcare and drinking water, and to weak environmental and health monitoring infrastructures. Escherichia coli (E. coli) is an indicator for the enteric pathogens that cause many diarrheal diseases. The links between E. coli, diarrheal diseases and environmental parameters have not received much attention in West Africa, and few studies have assessed health risks by taking into account hazards

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Sindi, Suzanne S., and Tricia R. Serio. "Prion dynamics and the quest for the genetic determinant in protein-only inheritance." Current Opinion in Microbiology 12, no. 6 (2009): 623–30. http://dx.doi.org/10.1016/j.mib.2009.09.003.

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