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1

IGWE, ORISA J., SHANE S. QUE HEE, and W. D. WAGNER. "Interaction between 1,2-Dichloroethane and Disulfiram." Toxicological Sciences 6, no. 4 (1986): 733–46. http://dx.doi.org/10.1093/toxsci/6.4.733.

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2

IGWE, O. "Interaction between 1,2-dichloroethane and disulfiram I. Toxicologic effects." Fundamental and Applied Toxicology 6, no. 4 (1986): 733–46. http://dx.doi.org/10.1016/0272-0590(86)90186-7.

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3

Brittebo, E. B., B. Kowalski, H. Ghantous, and I. Brandt. "Epithelial binding of 1,2-dichloroethane in mice." Toxicology 56, no. 1 (1989): 35–45. http://dx.doi.org/10.1016/0300-483x(89)90210-2.

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4

Li, Wenxue, Liping Chen, Yiwei Su, Hua Yin, Yaqin Pang, and Zhixiong Zhuang. "1,2-Dichloroethane induced nephrotoxicity through ROS mediated apoptosis in vitro and in vivo." Toxicology Research 4, no. 5 (2015): 1389–99. http://dx.doi.org/10.1039/c5tx00056d.

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5

Yllner, Sven. "Metabolism of 1,2-Dichloroethane-14C in the Mouse." Acta Pharmacologica et Toxicologica 30, no. 3-4 (2009): 257–65. http://dx.doi.org/10.1111/j.1600-0773.1971.tb00657.x.

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6

Igwe, Orisa J., Shane S. Que Hee, and William D. Wagner. "Interaction between 1,2-dichloroethane and tetraethylthiuram disulfide (disulfiram)." Toxicology and Applied Pharmacology 86, no. 2 (1986): 286–97. http://dx.doi.org/10.1016/0041-008x(86)90059-1.

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7

Zeng, Ni, Zhen Zhang, Hongmei Jiang, et al. "LncRNA-241 inhibits 1,2-Dichloroethane-induced hepatic apoptosis." Toxicology in Vitro 61 (December 2019): 104650. http://dx.doi.org/10.1016/j.tiv.2019.104650.

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8

PAYAN, J. P., A. M. SAILLENFAIT, P. BONNET, J. P. FABRY, I. LANGONNE, and J. P. SABATE. "Assessment of the Developmental Toxicity and Placental Transfer of 1,2-Dichloroethane in Rats." Toxicological Sciences 28, no. 2 (1995): 187–98. http://dx.doi.org/10.1093/toxsci/28.2.187.

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9

Payan, J. "Assessment of the Developmental Toxicity and Placental Transfer of 1,2-Dichloroethane in Rats." Fundamental and Applied Toxicology 28, no. 2 (1995): 187–98. http://dx.doi.org/10.1006/faat.1995.1159.

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10

Payan, J. P., D. Beydon, J. P. Fabry, M. T. Brondeau, M. Ban, and J. de Ceaurriz. "Urinary thiodiglycolic acid and thioether excretion in male rats dosed with 1,2-dichloroethane." Journal of Applied Toxicology 13, no. 6 (1993): 417–22. http://dx.doi.org/10.1002/jat.2550130608.

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11

Lin, Edith L. C., Joan K. Mattox, and Michael A. Pereira. "Glutathione plus cytosol- and microsome-mediated binding of 1,2-dichloroethane to polynucleotides." Toxicology and Applied Pharmacology 78, no. 3 (1985): 428–35. http://dx.doi.org/10.1016/0041-008x(85)90249-2.

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12

Wang, S. Y., Y. C. Kuo, Y. Z. Huang, C. W. Huang, and C. M. Kao. "Bioremediation of 1,2-dichloroethane contaminated groundwater: Microcosm and microbial diversity studies." Environmental Pollution 203 (August 2015): 97–106. http://dx.doi.org/10.1016/j.envpol.2015.03.042.

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13

Riebeth, D. M., N. O. Belser, and C. E. Castro. "Partial rapid metabolism of 1,2-dichloroethane byMethylosinus trichosporiumOB-3b." Environmental Toxicology and Chemistry 11, no. 4 (1992): 497–501. http://dx.doi.org/10.1002/etc.5620110407.

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14

Cottalasso, Damiano, Antonella Bellocchio, Raffaella Norese, et al. "Effects of vitamin E on dolichol content of rats acutely treated with 1,2-dichloroethane." Toxicology 143, no. 3 (2000): 283–92. http://dx.doi.org/10.1016/s0300-483x(99)00181-x.

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15

Story, David L., Earl F. Meierhenry, Charles A. Tyson, and Harry A. Milman. "Differences in Rat Liver Enzyme-Altered Foci Produced By Chlorinated Aliphatics and Phenobarbital." Toxicology and Industrial Health 2, no. 4 (1986): 351–62. http://dx.doi.org/10.1177/074823378600200402.

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Nine chlorinated aliphatics (CAs)—1,1-dichloroethane, 1,2-dichloro ethane, 1,1,1-trichloroethane, 1,1,2-trichloroethane, trichloro ethylene, tetrachloroethylene, 1,1,1,2-tetrachloroethane, 1,1,2,2- tetrachloroethane, and hexachloroethane—were examined in a rat liver foci assay for evidence of initiating and promoting potential. Young adult male Osborne-Mendel rats (ten/group) were given partial hepa tectomies, followed 24 hr later by a single i.p. dose of either diethyl nitrosamine (30 mg/kg body weight) or CA, 1 wk later either a diet containing 0.05% (w/w) phenobarbital or daily oral gavage
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16

Lone, Mohammad Iqbal, Nazia Nazam, Aashiq Hussain, et al. "Genotoxicity and immunotoxic effects of 1,2-dichloroethane in Wistar rats." Journal of Environmental Science and Health, Part C 34, no. 3 (2016): 169–86. http://dx.doi.org/10.1080/10590501.2016.1193924.

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17

Ma, Jie, Haiyan Li, Richard Spiese, John Wilson, Guangxu Yan, and Shaohui Guo. "Vapor intrusion risk of lead scavengers 1,2-dibromoethane (EDB) and 1,2-dichloroethane (DCA)." Environmental Pollution 213 (June 2016): 825–32. http://dx.doi.org/10.1016/j.envpol.2016.03.032.

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18

Muralidhara, S., R. Ramanathan, S. M. Mehta, L. H. Lash, D. Acosta, and J. V. Bruckner. "Acute, Subacute, and Subchronic Oral Toxicity Studies of 1,1-Dichloroethane in Rats: Application to Risk Evaluation." Toxicological Sciences 64, no. 1 (2001): 135–45. http://dx.doi.org/10.1093/toxsci/64.1.135.

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19

Riebeth, D. M., N. O. Belser, and C. E. Castro. "PARTIAL RAPID METABOLISM OF 1,2-DICHLOROETHANE BY METHYLOSINUS TRICHOSPORIUM OB-3b." Environmental Toxicology and Chemistry 11, no. 4 (1992): 497. http://dx.doi.org/10.1897/1552-8618(1992)11[497:prmodb]2.0.co;2.

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20

Sweeney, Lisa M., Shakil A. Saghir, and Michael L. Gargas. "Physiologically based pharmacokinetic model development and simulations for ethylene dichloride (1,2-dichloroethane) in rats." Regulatory Toxicology and Pharmacology 51, no. 3 (2008): 311–23. http://dx.doi.org/10.1016/j.yrtph.2008.05.002.

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21

McDermott, Catherine, and James J. A. Heffron. "Toxicity of Industrially Relevant Chlorinated Organic Solvents In Vitro." International Journal of Toxicology 32, no. 2 (2013): 136–45. http://dx.doi.org/10.1177/1091581813482006.

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The cytotoxic effects of 4 industrially important chlorinated organic solvents, dichloromethane (DCM), 1,2-dichloroethane (DCE), trichloroethylene (TCE), and tetrachloroethylene (PERC) in vitro, were investigated. Jurkat T cells were exposed to the solvents individually for 72 hours and changes in reactive oxygen species (ROS) formation, cell proliferation, intracellular free calcium concentration ([Ca2+]), and caspase-3 activity were measured. There was a concentration-dependent increase in the ROS formation and intracellular free [Ca2+] following exposure to each of the solvents. This was ac
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22

Colacci, Annamaria, Mario Mazzullo, Giancarlo Arfellini, Giorgio Prodi, and Sandro Grilli. "In vitro microsome- and cytosol-mediated binding of 1,2-dichloroethane and 1,2-dibromoethane with DNA." Cell Biology and Toxicology 1, no. 2 (1985): 45–55. http://dx.doi.org/10.1007/bf00717790.

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23

Baertsch, Amadeus, Werner K. Lutz, and Christian Schlatter. "Effect of inhalation exposure regimen on DNA binding potency of 1,2-dichloroethane in the rat." Archives of Toxicology 65, no. 3 (1991): 169–76. http://dx.doi.org/10.1007/bf02307305.

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24

Hughes, K., M. E. Meek, and I. Caldwell. "1,2‐Dichloroethane: Evaluation of risks to health from environmental exposure in Canada." Journal of Environmental Science and Health, Part C 12, no. 2 (1994): 293–303. http://dx.doi.org/10.1080/10590509409373448.

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25

Huang, Manqi, Yizhou Zhong, Li Lin, et al. "1,2-Dichloroethane induces cerebellum granular cell apoptosis via mitochondrial pathway in vitro and in vivo." Toxicology Letters 322 (April 2020): 87–97. http://dx.doi.org/10.1016/j.toxlet.2020.01.004.

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26

Laurent, Bodin, Solal Cécilia, Roudot Alain-Claude, et al. "Proposal of a new carcinogenic toxicological reference value (TRV) for inhalation exposure to 1,2-dichloroethane." Toxicology Letters 189 (September 2009): S242. http://dx.doi.org/10.1016/j.toxlet.2009.06.460.

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27

Frederick Frasch, H., Ana M. Barbero, Houda Alachkar, and James N. McDougal. "Skin Penetration And Lag Times Of Neat And Aqueous Diethyl Phthalate, 1,2-Dichloroethane And Naphthalene." Cutaneous and Ocular Toxicology 26, no. 2 (2007): 147–60. http://dx.doi.org/10.1080/15569520701212274.

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28

Storer, Richard D., and Rory B. Conolly. "An investigation of the role of microsomal oxidative metabolism in the in vivo genotoxicity of 1,2-dichloroethane." Toxicology and Applied Pharmacology 77, no. 1 (1985): 36–46. http://dx.doi.org/10.1016/0041-008x(85)90265-0.

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29

Mohsenzadeh, Mahdi, Seyed Ahmad Mirbagheri, and Samad Sabbaghi. "Degradation of 1,2-dichloroethane by photocatalysis using immobilized PAni-TiO2 nano-photocatalyst." Environmental Science and Pollution Research 26, no. 30 (2019): 31328–43. http://dx.doi.org/10.1007/s11356-019-06240-5.

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30

Giri, Ashok Kumar, and Shane S. Quehee. "In vivo sister chromatid exchange induced by 1,2-dichloroethane on bone marrow cells of mice." Environmental Mutagenesis 12, no. 3 (1988): 331–34. http://dx.doi.org/10.1002/em.2860120307.

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31

Daniel, F. Bernard, Merrel Robinson, Greg R. Olson, Raymond G. York, and L. W. Condie. "Ten and Ninety-Day Toxicity Studies of 1,2-Dichloroethane in Sprague-Dawley Rats." Drug and Chemical Toxicology 17, no. 4 (1994): 463–77. http://dx.doi.org/10.3109/01480549409014312.

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32

Siddiqui, M. KJ, U. Nigam, S. Srivastava, D. S. Tejeshwar, and Chandrawati. "Association of maternal blood pressure and hemoglobin level with organochlorines in human milk." Human & Experimental Toxicology 21, no. 1 (2002): 1–6. http://dx.doi.org/10.1191/0960327102ht198oa.

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Milk samples of women from the general population in Lucknow were analysed by gas–liquid chromatography to determine the concentration of organochlorine pesticides and their possible association with maternal characteristics. p,p0-DDT (dichloro diphenyltrichloroethane),p,p-DDE (dichloro diphenyl trichloroethylene), p,p0-DDD (dichloro diphenyl dichloroethane), ¬, 00ad, fi and flisomers of hexachlorocyclohexane (HCH) and aldrin were detected. The calculated daily intake of DDT and HCH by the neonates exceeded their acceptable daily intake (ADI) set by the WHO. A statistically significant associa
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33

Thomas, L., B. DeFeo, M. F. Mariani, and G. D. V. van Rossum. "Comparison of metabolic effects of carbon tetrachloride and 1,2-dichloroethane added in vitro to slices of rat liver." Toxicology in Vitro 3, no. 1 (1989): 59–68. http://dx.doi.org/10.1016/0887-2333(89)90025-8.

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34

Ansari, G. A. S., Jose C. Gan, and Brian K. Barton. "Synergistic inactivation of plasma ?1-proteinase inhibitor by aldehydes of cigarette smoke with styrene oxide and 1,2-dichloroethane." Archives of Environmental Contamination and Toxicology 17, no. 4 (1988): 533–36. http://dx.doi.org/10.1007/bf01055520.

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35

Eldakroory, SA, DA El Morsi, RH Abdel-Rahman, S. Roshdy, MS Gouida, and EO Khashaba. "Correlation between toxic organochlorine pesticides and breast cancer." Human & Experimental Toxicology 36, no. 12 (2017): 1326–34. http://dx.doi.org/10.1177/0960327116685887.

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Organochlorines (OCs) are common environmental pollutants that have been linked to cancer. This work aims to assess the role of OCs as a risk factor for breast cancer and to evaluate the cellular changes induced by exposure to such environmental contaminants. The study included 70 cancer patients subjected to thorough history taking and routine investigations. Samples from tumor and normal adjacent tissue were taken to measure OCs’ levels and to perform molecular analysis (some oncogenic and apoptotic markers) by flow cytometry. There were significantly higher concentrations of methoxychlor, d
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36

Boverhof, D. R., J. A. Hotchkiss, M. J. LeBaron, L. M. Segal, and C. Howick. "Investigation of the potential non-genotoxic mode of action for 1,2-Dichloroethane (DCE)-induced mammary tumors in female rats." Toxicology Letters 295 (October 2018): S150—S151. http://dx.doi.org/10.1016/j.toxlet.2018.06.750.

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37

Kramers, P. G. N., H. C. A. Mout, B. Bissumbhar, and C. R. Mulder. "Inhalation exposure in Drosophila mutagenesis assays: experiments with aliphatic halogenated hydrocarbons, with emphasis on the genetic activity profile of 1,2-dichloroethane." Mutation Research/Environmental Mutagenesis and Related Subjects 252, no. 1 (1991): 17–33. http://dx.doi.org/10.1016/0165-1161(91)90248-7.

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38

SCHULZ, GÜNTER, and GISELA BIRKHAHN. "Kinetic Analogies Between Decomposition of 1,2-Dichloroethane and Chloroform Under Non-Thermal Reducing RF Plasma Conditions." Hazardous Waste and Hazardous Materials 13, no. 4 (1996): 465–72. http://dx.doi.org/10.1089/hwm.1996.13.465.

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39

Zhang, Lin, and Ya‐ping Jin. "Toxic effects of combined treatment of 1,2‐dichloroethane and ethanol on mouse brain and the related mechanisms." Journal of Biochemical and Molecular Toxicology 33, no. 5 (2019): e22294. http://dx.doi.org/10.1002/jbt.22294.

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40

Zhong, Yizhou, Boxuan Liang, Manjiang Hu, et al. "MicroRNA-29b-3p aggravates 1,2-dichloroethane-induced brain edema by targeting aquaporin 4 in Sprague-Dawley rats and CD-1 mice." Toxicology Letters 319 (February 2020): 160–67. http://dx.doi.org/10.1016/j.toxlet.2019.11.011.

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41

Liang, Boxuan, Yizhou Zhong, Bo Wang, et al. "1,2-Dichloroethane induces apoptosis in the cerebral cortexes of NIH Swiss mice through microRNA-182-5p targeting phospholipase D1 via a mitochondria-dependent pathway." Toxicology and Applied Pharmacology 430 (November 2021): 115728. http://dx.doi.org/10.1016/j.taap.2021.115728.

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42

Lund, B. O., Å. Bergman, and I. Brandt. "In vitro macromolecular binding of 2-(2-chlorophenyl)-2-(4-chlorophenyl)-1,1-dichloroethane (o,p′-DDD) in the mouse lung and liver." Chemico-Biological Interactions 70, no. 1-2 (1989): 63–72. http://dx.doi.org/10.1016/0009-2797(89)90063-x.

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43

Suguro, Mayuko, Takamasa Numano, Mayumi Kawabe, et al. "Lung Tumor Induction by 26-week Dermal Application of 1,2-Dichloroethane in CB6F1-Tg rasH2 Mice." Toxicologic Pathology 45, no. 3 (2017): 427–34. http://dx.doi.org/10.1177/0192623317701003.

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Short-term alternatives to traditional 2-year carcinogenic studies in rodents are being actively pursued. Recently, a 26-week short-term carcinogenicity study using CB6F1-Tg rasH2@Jcl (rasH2) mice has become a worldwide standard for the evaluation of chemical carcinogenesis. However, an acceptable short-term carcinogenic study model for dermally applied products is still lacking. To investigate the suitability of using the rasH2 mouse to test carcinogenic potential, 1,2-dichloroethane (1,2-DCE) was dermally applied to rasH2 mice: 1,2-DCE is a known carcinogen that causes lung bronchiolo-alveol
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44

Wang, Gaoyang, Yuan Yuan, Jun Zhang, et al. "Roles of aquaporins and matrix metalloproteinases in mouse brain edema formation induced by subacute exposure to 1,2-dichloroethane." Neurotoxicology and Teratology 44 (July 2014): 105–12. http://dx.doi.org/10.1016/j.ntt.2014.06.005.

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45

Jin, Xiaoxia, Yingjun Liao, Xiaoqiong Tan, et al. "Involvement of the p38 MAPK signaling pathway in overexpression of matrix metalloproteinase-9 during the course of brain edema in 1,2-dichloroethane-intoxicated mice." NeuroToxicology 69 (December 2018): 296–306. http://dx.doi.org/10.1016/j.neuro.2018.07.022.

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46

Leblond, Vincent S., and Alice Hontela. "Effects ofin VitroExposures to Cadmium, Mercury, Zinc, and 1-(2-Chlorophenyl)-1-(4-chlorophenyl)-2,2-dichloroethane on Steroidogenesis by Dispersed Interrenal Cells of Rainbow Trout (Oncorhynchus mykiss)." Toxicology and Applied Pharmacology 157, no. 1 (1999): 16–22. http://dx.doi.org/10.1006/taap.1999.8660.

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47

Zhou, Zhengyuan, Jingyao Huang, Muhammad Danish, et al. "Insights into enhanced removal of 1,2-dichloroethane by amorphous boron-enhanced Fenton system: Performances and mechanisms." Journal of Hazardous Materials 420 (October 2021): 126589. http://dx.doi.org/10.1016/j.jhazmat.2021.126589.

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48

JENSEN, B. "Toxicity, ultrastructural effects, and metabolic studies with 1-(o-chlorophenyl)-1-(p-chlorophenyl)-2,2-dichloroethane(o,p?-DDD) and its methyl analog in the guinea pig and rat*1." Toxicology and Applied Pharmacology 87, no. 1 (1987): 1–9. http://dx.doi.org/10.1016/0041-008x(87)90078-0.

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49

Wei, Yu-Ting, Shian-chee Wu, Shi-Wei Yang, Choi-Hong Che, Hsing-Lung Lien, and De-Huang Huang. "Biodegradable surfactant stabilized nanoscale zero-valent iron for in situ treatment of vinyl chloride and 1,2-dichloroethane." Journal of Hazardous Materials 211-212 (April 2012): 373–80. http://dx.doi.org/10.1016/j.jhazmat.2011.11.018.

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50

Al-Baldawi, Israa Abdulwahab. "Removal of 1,2-Dichloroethane from real industrial wastewater using a sub-surface batch system with Typha angustifolia L." Ecotoxicology and Environmental Safety 147 (January 2018): 260–65. http://dx.doi.org/10.1016/j.ecoenv.2017.08.022.

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