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Artículos de revistas sobre el tema "Digestive cancers"

Autor: Grafiati

Publicado: 11 de enero de 2025

Última modificación: 31 de julio de 2025

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1

Adianto Nugroho, Fransicus Arifin, Perwira Widianto, et al. "Digestive Surgery Services in COVID-19 Pandemic Period: Indonesian Society of Digestive Surgeons Position Statement." Journal Of The Indonesian Medical Association 70, no. 6 (2020): 132–41. http://dx.doi.org/10.47830/jinma-vol.70.6-2020-239.

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Digestive surgery service including surgical management of gastrointestinal disease and digestive cancers are experiencing the impact of COVID-19 pandemic. Therefore it is necessary to formulate recommendation for digestives surgery service, as guidelines to engage in case-by-case assessment of particular patients with digestive diseases. We are aware that the knowledge and science of COVID-19 are still evolving, with new progression every day. This recommendation reflect actual condition and are subject for future adjustment in the future.

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2

Zheng, Jiachen, Ming Zhao, Jiahui Li, et al. "Obesity-associated digestive cancers: A review of mechanisms and interventions." Tumor Biology 39, no. 3 (2017): 101042831769502. http://dx.doi.org/10.1177/1010428317695020.

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The prevalence of obesity has steadily increased over the past few decades. Previous studies suggest that obesity is an oncogenic factor and that over 20% of all cancers are obesity-related. Among such cancers, digestive system malignancies (including esophageal adenocarcinomas, colorectal cancers, and cancers of the gastric cardia, liver, and pancreas) are reported most frequently. While the 5-year survival rates of cancers of the breast and prostate are 90%, that rate is only 45% for digestive cancers. In this review, the mechanisms of obesity-associated digestive cancers are discussed, with

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3

Yang, Ting-Fang, Xin-Rui Li, and Mo-Wei Kong. "Molecular mechanisms underlying roles of long non-coding RNA small nucleolar RNA host gene 16 in digestive system cancers." World Journal of Gastrointestinal Oncology 16, no. 11 (2024): 4300–4308. http://dx.doi.org/10.4251/wjgo.v16.i11.4300.

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This editorial reviews the molecular mechanisms underlying the roles of the long non-coding RNA (lncRNA) small nucleolar RNA host gene 16 (SNHG16 ) in digestive system cancers based on two recent studies on lncRNAs in digestive system tumors. The first study, by Zhao et al , explored how hBD-1 affects colon cancer, via the lncRNA TCONS_00014506 , by inhibiting mTOR and promoting autophagy. The second one, by Li et al , identified the lncRNA prion protein testis specific (PRNT ) as a factor in oxaliplatin resistance by sponging ZNF184 to regulate HIPK2 and influence colorectal cancer progressio

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4

Zhang, Tao, Bofang Wang, Baohong Gu, et al. "Genetic and Molecular Characterization Revealed the Prognosis Efficiency of Histone Acetylation in Pan-Digestive Cancers." Journal of Oncology 2022 (April 5, 2022): 1–21. http://dx.doi.org/10.1155/2022/3938652.

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The imbalance between acetylation and deacetylation of histone proteins, important for epigenetic modifications, is closely associated with various diseases, including cancer. However, knowledge regarding the modification of histones across the different types of digestive cancers is still lacking. The purpose of this research was to analyze the role of histone acetylation and deacetylation in pan-digestive cancers. We systematically characterized the molecular alterations and clinical relevance of 13 histone acetyltransferase (HAT) and 18 histone deacetylase (HDAC) genes in five types of dige

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5

Turati, Federica, Marta Rossi, Claudio Pelucchi, Fabio Levi, and Carlo La Vecchia. "Fruit and vegetables and cancer risk: a review of southern European studies." British Journal of Nutrition 113, S2 (2015): S102—S110. http://dx.doi.org/10.1017/s0007114515000148.

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High intakes of fruit and vegetables may reduce the risk of cancer at several sites. Evidence has been derived mainly from case–control studies. We reviewed the relationship between consumption of vegetables and fruit and the risk of several common cancers in a network of Italian and Swiss case–control studies including over 10 000 cases of fourteen different cancers and about 17 000 controls. Data were suggestive of a protective role of vegetable intake on the risk of several common epithelial cancers. OR for the highest compared with the lowest levels of consumption ranged from 0·2 (larynx,

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6

Capparelli, Rosanna, Paola Cuomo, Antonio Gentile, and Domenico Iannelli. "Microbiota–Liver Diseases Interactions." International Journal of Molecular Sciences 24, no. 4 (2023): 3883. http://dx.doi.org/10.3390/ijms24043883.

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Gut microbiota regulates essential processes of host metabolism and physiology: synthesis of vitamins, digestion of foods non-digestible by the host (such as fibers), and—most important—protects the digestive tract from pathogens. In this study, we focus on the CRISPR/Cas9 technology, which is extensively used to correct multiple diseases, including liver diseases. Then, we discuss the non-alcoholic fatty liver disease (NAFLD), affecting more than 25% of the global population; colorectal cancer (CRC) is second in mortality. We give space to rarely discussed topics, such as pathobionts and mult

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7

Yuan, Xiao, Ya Yuan, Zhi He, et al. "The Regulatory Functions of Circular RNAs in Digestive System Cancers." Cancers 12, no. 3 (2020): 770. http://dx.doi.org/10.3390/cancers12030770.

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Circular ribonucleic acids (circRNAs), which are a type of covalently closed circular RNA, are receiving increasing attention. An increasing amount of evidence suggests that circRNAs are involved in the biogenesis and development of multiple diseases such as digestive system cancers. Dysregulated circRNAs have been found to act as oncogenes or tumour suppressors in digestive system cancers. Moreover, circRNAs are related to ageing and a wide variety of processes in tumour cells, such as cell apoptosis, invasion, migration, and proliferation. Moreover, circRNAs can perform a remarkable multitud

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8

Zhang, Hongli, Qingqing Feng, Wei-Dong Chen, and Yan-Dong Wang. "HGF/c-MET: A Promising Therapeutic Target in the Digestive System Cancers." International Journal of Molecular Sciences 19, no. 11 (2018): 3295. http://dx.doi.org/10.3390/ijms19113295.

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The HGF/c-MET pathway is active in the development of digestive system cancers, indicating that inhibition of HGF/c-MET signaling may have therapeutic potential. Various HGF/c-MET signaling inhibitors, mainly c-MET inhibitors, have been tested in clinical trials. The observed efficacy and adverse events of some c-MET inhibitors were not very suitable for treating digestive system cancers. The development of new HGF/c-MET inhibitors in preclinical studies may bring promising treatments and synergistic combination (traditional anticancer drugs and c-MET inhibitors) strategies provided anacceptab

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9

Zhang, Nan, Yueying Wang, Gary Tse, Guangping Li, Shouling Wu, and Tong Liu. "Association of Visit-to-Visit Variability in Fasting Plasma Glucose with Digestive Cancer Risk." Oxidative Medicine and Cellular Longevity 2022 (July 13, 2022): 1–12. http://dx.doi.org/10.1155/2022/4530894.

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Background and Aims. The aim of this study is to investigate the association between visit-to-visit variability in fasting plasma glucose (FPG) and the risk of digestive cancers among individuals with and without diabetes. Methods. Using data from Kailuan cohort, a prospective population-based study, individuals who had at least two measurements of FPG between 2006 and 2012 without prior cancer were included in this study. Four indexes of variability were used, including standard deviation (SD), coefficient of variation (CV), variability independent of the mean (VIM), and average successive va

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10

Xiong, Zuming, Yongjun Yang, Wenxin Li, Yirong Lin, Wei Huang, and Sen Zhang. "Exploring Key Biomarkers and Common Pathogenesis of Seven Digestive System Cancers and Their Correlation with COVID-19." Current Issues in Molecular Biology 45, no. 7 (2023): 5515–33. http://dx.doi.org/10.3390/cimb45070349.

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Digestive system cancer and COVID-19 significantly affect the digestive system, but the mechanism of interaction between COVID-19 and the digestive system cancers has not been fully elucidated. We downloaded the gene expression of COVID-19 and seven digestive system cancers (oral, esophageal, gastric, colorectal, hepatocellular, bile duct, pancreatic) from GEO and identified hub differentially expressed genes. Multiple verifications, diagnostic efficacy, prognostic analysis, functional enrichment and related transcription factors of hub genes were explored. We identified 23 common DEGs for sub

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11

Ishikawa, Marin, Kohei Nakamura, Ryutaro Kawano, et al. "Clinical and Diagnostic Utility of Genomic Profiling for Digestive Cancers: Real-World Evidence from Japan." Cancers 16, no. 8 (2024): 1504. http://dx.doi.org/10.3390/cancers16081504.

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The usefulness of comprehensive genomic profiling (CGP) in the Japanese healthcare insurance system remains underexplored. Therefore, this large-scale study aimed to determine the usefulness of CGP in diagnosing digestive cancers. Patients with various cancer types recruited between March 2020 and October 2022 underwent the FoundationOne® CDx assay at the Keio PleSSision Group (19 hospitals in Japan). A scoring system was developed to identify potentially actionable genomic alterations of biological significance and actionable genomic alterations. The detection rates for potentially actionable

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12

Lai, Yue, Jun Mi, and Qiang Feng. "Fusobacterium nucleatum and Malignant Tumors of the Digestive Tract: A Mechanistic Overview." Bioengineering 9, no. 7 (2022): 285. http://dx.doi.org/10.3390/bioengineering9070285.

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Fusobacterium nucleatum (F. nucleatum) is an oral anaerobe that plays a role in several oral diseases. However, F. nucleatum is also found in other tissues of the digestive tract, and several studies have recently reported that the level of F. nucleatum is significantly elevated in malignant tumors of the digestive tract. F. nucleatum is proposed as one of the risk factors in the initiation and progression of digestive tract malignant tumors. In this review, we summarize recent reports on F. nucleatum and its role in digestive tract cancers and evaluate the mechanisms underlying the action of

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13

Sandaly, Diakite, Camara Fode Lansana, Diakite Saikou Yaya, et al. "Digestive Tract Cancers: Epidemiological, Anatomical and Clinical Aspects and Management at Conakry Hospital." Cancer Research Journal 12, no. 1 (2024): 16–20. http://dx.doi.org/10.11648/j.crj.20241201.14.

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Introduction: Digestive cancers represent between 10 and 50% of all cancers and therefore occupy a preponderant place in digestive surgery departments. Our general objective was to study the epidemiological, anatomo-clinical and therapeutic aspects of cancers of the digestive tract at the Conakry University Hospital. Methodology: This was a retrospective descriptive study covering a period of 6 years, from January 1, 2014 to December 31, 2019. Result: the hospital prevalence of cancers of the digestive tract was 6.34% with a male predominance of 54% and a sex ratio of 1.17. The average age was

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14

Chen, Siyuan, Hui Dong, Shiming Yang, and Hong Guo. "Cathepsins in digestive cancers." Oncotarget 8, no. 25 (2017): 41690–700. http://dx.doi.org/10.18632/oncotarget.16677.

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15

Gonzalez, A. Llopis, M. Morales Suarez-Varela, and R. Rodriguez Martin. "Other digestive tract cancers." European Journal of Cancer Prevention 1 (October 1991): 28. http://dx.doi.org/10.1097/00008469-199110001-00049.

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16

Vaque, J., L. Armadans, J. Penella, P. Quesada, and J. Rossello. "Other digestive tract cancers." European Journal of Cancer Prevention 1 (October 1991): 29. http://dx.doi.org/10.1097/00008469-199110001-00050.

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17

Paz-Houza, J. I., M. M. Abad, E. Munoz, and A. Bullon. "Other digestive tract cancers." European Journal of Cancer Prevention 1 (October 1991): 29. http://dx.doi.org/10.1097/00008469-199110001-00051.

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18

McCarthy, Michael. "Aspirin and digestive cancers." Lancet 341, no. 8848 (1993): 821. http://dx.doi.org/10.1016/0140-6736(93)90589-9.

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19

Cai, Xianlei, Xueying Li, Mengyao Tang, et al. "Dietary carbohydrate intake, glycaemic index, glycaemic load and digestive system cancers: an updated dose–response meta-analysis." British Journal of Nutrition 121, no. 10 (2019): 1081–96. http://dx.doi.org/10.1017/s0007114519000424.

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Abstract Several studies analysed the associations between dietary carbohydrate intake, glycaemic index (GI) and glycaemic load (GL) and digestive system cancers; however, the results remain controversial. This study was to perform a meta-analysis evaluating the quantitative and dose–response associations between carbohydrate intake, GI and GL, and risk of digestive system cancers. We searched medical and biological databases up to June 2018 and identified twenty-six cohort studies and eighteen case–control studies. Meta-analytic fixed or random effects models were applied to process data. We

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20

Gan, Xiaoning, Guanqi Dai, Yonghao Li, Lin Xu, and Guolong Liu. "Intricate roles of estrogen and estrogen receptors in digestive system cancers: a systematic review." Cancer Biology & Medicine 21, no. 10 (2024): 898–915. http://dx.doi.org/10.20892/j.issn.2095-3941.2024.0224.

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Gender disparities are evident across different types of digestive system cancers, which are typically characterized by a lower incidence and mortality rate in females compared to males. This finding suggests a potential protective role of female steroid hormones, particularly estrogen, in the development of these cancers. Estrogen is a well-known sex hormone that not only regulates the reproductive system but also exerts diverse effects on non-reproductive organs mediated through interactions with estrogen receptors (ERs), including the classic (ERα and ERβ) and non-traditional ERs [G protein

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21

Stokłosa, Paulina, Anna Borgström, Sven Kappel, and Christine Peinelt. "TRP Channels in Digestive Tract Cancers." International Journal of Molecular Sciences 21, no. 5 (2020): 1877. http://dx.doi.org/10.3390/ijms21051877.

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Cancers of the digestive tract are among the most prevalent types of cancer. These types of cancers are often diagnosed at a late stage, which results in a poor prognosis. Currently, many biomedical studies focus on the role of ion channels, in particular transient receptor potential (TRP) channels, in cancer pathophysiology. TRP channels show mostly non-selective permeability to monovalent and divalent cations. TRP channels are often dysregulated in digestive tract cancers, which can result in alterations of cancer hallmark functions, such as enhanced proliferation, migration, invasion and th

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22

Reitano, Elisa, Nicola de’Angelis, Paschalis Gavriilidis, et al. "Oral Bacterial Microbiota in Digestive Cancer Patients: A Systematic Review." Microorganisms 9, no. 12 (2021): 2585. http://dx.doi.org/10.3390/microorganisms9122585.

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The relation between the gut microbiota and human health is increasingly recognized. Recently, some evidence suggested that dysbiosis of the oral microbiota may be involved in the development of digestive cancers. A systematic review was conducted according to the PRISMA guidelines to investigate the association between the oral microbiota and digestive cancers. Several databases including Medline, Scopus, and Embase were searched by three independent reviewers, without date restriction. Over a total of 1654 records initially identified, 28 studies (2 prospective cohort studies and 26 case-con

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23

Olivier, Raphael, Violaine Randrian, David Tougeron, and Jean-Christophe Saurin. "Endoscopy to Diagnose and Prevent Digestive Cancers in Lynch Syndrome." Cancers 13, no. 14 (2021): 3505. http://dx.doi.org/10.3390/cancers13143505.

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Lynch syndrome patients could benefit from various recommendations to prevent digestive cancers. In this review, we summarize the criteria to identify Lynch syndrome in patients with digestive cancers. We detail endoscopic screening procedures in patients with Lynch syndrome for gastric, small bowel, pancreatic, and colorectal cancers. We review the precise modalities of endoscopic follow-up, particularly the discrepancies that exist between the guidelines of the various scientific societies. We discuss the treatment of colorectal cancers in Lynch syndrome cases and patient adherence to endosc

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24

Yeh, Kun-Huei. "Awardee Summary of 2023 Taiwan Oncology Society Clinical Research Award Recipient: Persistent Endeavors on Research of Digestive Cancers for Three Decades." Journal of Cancer Research and Practice 11, no. 1 (2024): 1–6. http://dx.doi.org/10.4103/ejcrp.ejcrp-d-23-00044.

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Abstract Objective: Digestive cancers account for five of the top ten cancer-related deaths in Taiwan. Our team has made persistent endeavors in translational research and clinical trials of digestive cancers for almost three decades. Data Sources and Study Selection: We enrolled relevant translational and clinical studies for digestive cancers published by our groups in the past three decades. Results: First, we developed a unique weekly 24-h infusion of high-dose 5-fluorouracil (5-FU) and leucovorin regimen (HDFL) in 1992. HDFL exhibits satisfactory single-agent activity, minimal myelosuppre

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Valean, Simona, Romeo Chira, and Dan Dumitrascu. "Epidemiological trends in digestive cancers compared to trends in alcohol consumption. Facts from Romania: correlation or coincidence?" Medicine and Pharmacy Reports 91, no. 4 (2018): 376–86. http://dx.doi.org/10.15386/cjmed-1067.

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Cancer has emerged as the leading cause of death in human populations, according to recent estimations. Epidemiological studies emphasized the role of life style and of environmental factors in promoting the risk for digestive cancers. The contribution of alcohol was highly suspected. Even for digestive cancers with dominant infection etiology, like liver cancer and gastric cancer, the contribution of alcohol should be assessed. At population level there is therefore a need to compare trends in epidemiological data of gastrointestinal cancers and data on alcohol consumption, in order to extrap

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Constantin, Adrian, Roxana Constantin, Florin Achim, Bogdan Socea, and Dragos Predescu. "Pregnancy and Gastric Cancer: A Narrative Review." Diagnostics 13, no. 11 (2023): 1909. http://dx.doi.org/10.3390/diagnostics13111909.

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Cases of digestive cancers diagnosed during pregnancy are rare. The increasing prevalence of pregnancy in women aged 30–39 years (and not exceptionally 40–49 years) could explain the frequent co-occurrence of cancers and pregnancy. The diagnosis of digestive cancers in pregnancy is difficult due to the overlap between neoplasm symptomatology and the clinical picture of pregnancy. A paraclinical evaluation may also be difficult depending on the trimester of the pregnancy. Diagnosis is also delayed by practitioners’ hesitation to use invasive investigations (imaging, endoscopy, etc.) due to feta

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Vecchia, Carlo La, and Cristina Bosetti. "Diet and cancer risk in Mediterranean countries: open issues." Public Health Nutrition 9, no. 8A (2006): 1077–82. http://dx.doi.org/10.1017/s1368980007668475.

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AbstractObjectiveTo analyse various aspects of the Mediterranean diet in relation to the risk of several common cancers in Italy.DesignData from a series of case-control studies conducted in northern Italy between 1983 and 2004 on over 20 000 cases of several major cancers and 18 000 controls.ResultsFor most digestive tract cancers, the risk decreased with increasing vegetable and fruit consumption, with relative risks between 0.3 and 0.7 for the highest level of intake, and the population-attributable risks for low intake of vegetables and fruit ranged between 15 and 40%. Less strong inverse

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Chai, Sanbao, Shuqing Yu, Zhirong Yang, et al. "Effect of incretin-based therapies on cancers of digestive system among 101 595 patients with type 2 diabetes mellitus: a systematic review and network meta-analysis combining 84 trials with a median duration of 30 weeks." BMJ Open Diabetes Research & Care 7, no. 1 (2019): e000728. http://dx.doi.org/10.1136/bmjdrc-2019-000728.

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ObjectivesTo evaluate the risk of cancers of digestive system with incretin-based therapies among patients with type 2 diabetes mellitus.Research design and methodsMedline, Embase, Cochrane Library and ClinicalTrials.gov databases were searched for randomized controlled clinical trials that compared incretin-based drugs with placebo or other antidiabetic drugs. Paired reviewers independently screened citations, extracted data and assessed risk of bias of included studies. Network meta-analysis was performed, followed by subgroup analysis. The Grading of Recommendations Assessment, Development

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PITU, FLAVIU, SERGIU PASCA, CALIN POPA, and AL HAJJAR NADIM. "The importance of MLH1, MSH2, MSH6 and PMS2 in determining DNA damage response in digestive cancers." Romanian Biotechnological Letters 26, no. 1 (2021): 2289–94. http://dx.doi.org/10.25083/rbl/26.1/2289.2294.

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Introduction: Genomic instability is a common feature across human cancers, but presents variation across different types of cancer, patients and cells of from the same tumor.This can be caused either by changes in the DNA damage repair pathways, aberrant histone modifications or methylation. The aim of this study was to determine the common mutated genes between digestive cancers that present genomic instability and to determine the biological processes in which these are implicated. Material and Methods: Mutational profiles for patients presenting digestive cancers and mutations in MLH1, MSH

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Zhou, Liyun, Zhenhua Jiang, Jing Gu, Wenhui Gu, and Shuangyin Han. "B7-H3 and digestive system cancers." European Journal of Inflammation 19 (January 2021): 205873922110005. http://dx.doi.org/10.1177/20587392211000581.

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Digestive system cancers (DSC) are the most common cancers worldwide and often associated with poor prognosis because of their characteristics of invasive and metastatic. Thus, it is particularly necessary to find novel molecular targets for early diagnosis, as well as targeted treatment of DSC. B7-H3, which was previously referred to as a modulatory ligand that regulate T-cell-mediated immune reaction, is a B7-family member of co-stimulatory biomolecules, and in recent years it was found that its concentration was remarkably up modulated in serum, as well as tissues of DSC patients. Numerous

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Valean, Simona, Monica Acalovschi, Mircea Diculescu, et al. "Mortality in Digestive Cancers, 2012: International Data and Data from Romania." Journal of Gastrointestinal and Liver Diseases 24, no. 4 (2015): 507–14. http://dx.doi.org/10.15403/jgld.2014.1121.244.rom.

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We aimed to compare the difference in case fatality rate between more developed and very high Human Development Index (HDI) regions, less developed and low HDI regions, and Romania. The incidence and mortality rates for digestive cancers were obtained from the IARC/WHO 2012 database. World mean mortality-to-incidence ratios registered the highest values in pancreatic cancer (0.97/0.94), and liver cancer (0.93/0.96) in males/females, respectively. The lowest values were recorded in colorectal cancer (0.48 in both sexes). Mortality-to-incidence ratios were generally higher in less developed area

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Auwercx, Julie, Pierre Rybarczyk, Philippe Kischel, et al. "Mg2+ Transporters in Digestive Cancers." Nutrients 13, no. 1 (2021): 210. http://dx.doi.org/10.3390/nu13010210.

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Despite magnesium (Mg2+) representing the second most abundant cation in the cell, its role in cellular physiology and pathology is far from being elucidated. Mg2+ homeostasis is regulated by Mg2+ transporters including Mitochondrial RNA Splicing Protein 2 (MRS2), Transient Receptor Potential Cation Channel Subfamily M, Member 6/7 (TRPM6/7), Magnesium Transporter 1 (MAGT1), Solute Carrier Family 41 Member 1 (SCL41A1), and Cyclin and CBS Domain Divalent Metal Cation Transport Mediator (CNNM) proteins. Recent data show that Mg2+ transporters may regulate several cancer cell hallmarks. In this re

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Gilly, F. N., A. C. Sayag-Beaujard, P. Y. Carry, et al. "INTRAPERITONEAL CHEMOHYPERTHERMIA IN DIGESTIVE CANCERS." Southern Medical Journal 89, Supplement (1996): S142. http://dx.doi.org/10.1097/00007611-199610001-00303.

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Zhou, Ying, and Guang-Hua Luo. "Porphyromonas gingivalisand digestive system cancers." World Journal of Clinical Cases 7, no. 7 (2019): 819–29. http://dx.doi.org/10.12998/wjcc.v7.i7.819.

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Bedenne, L., E. Dorval, F. Tusseau, et al. "French Guidelines for Digestive Cancers." Gastroentérologie Clinique et Biologique 30 (September 2006): 3–4. http://dx.doi.org/10.1016/s0399-8320(06)73583-7.

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Wu, Ruo-Lin, Lei Huang, Hong-Chuan Zhao, and Xiao-Ping Geng. "Hyaluronic acid in digestive cancers." Journal of Cancer Research and Clinical Oncology 143, no. 1 (2016): 1–16. http://dx.doi.org/10.1007/s00432-016-2213-5.

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Tron, Laure, Mathieu Fauvernier, Anne-Marie Bouvier, et al. "Socioeconomic Environment and Survival in Patients with Digestive Cancers: A French Population-Based Study." Cancers 13, no. 20 (2021): 5156. http://dx.doi.org/10.3390/cancers13205156.

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Social inequalities are an important prognostic factor in cancer survival, but little is known regarding digestive cancers specifically. We aimed to provide in-depth analysis of the contextual social disparities in net survival of patients with digestive cancer in France, using population-based data and relevant modeling. Digestive cancers (n = 54,507) diagnosed between 2006–2009, collected through the French network of cancer registries, were included (end of follow-up 30 June 2013). Social environment was assessed by the European Deprivation Index. Multidimensional penalized splines were use

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Profir, Monica, Oana Alexandra Roşu, Sanda Maria Creţoiu, and Bogdan Severus Gaspar. "Friend or Foe: Exploring the Relationship between the Gut Microbiota and the Pathogenesis and Treatment of Digestive Cancers." Microorganisms 12, no. 5 (2024): 955. http://dx.doi.org/10.3390/microorganisms12050955.

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Digestive cancers are among the leading causes of cancer death in the world. However, the mechanisms of cancer development and progression are not fully understood. Accumulating evidence in recent years pointing to the bidirectional interactions between gut dysbiosis and the development of a specific type of gastrointestinal cancer is shedding light on the importance of this “unseen organ”—the microbiota. This review focuses on the local role of the gut microbiota imbalance in different digestive tract organs and annexes related to the carcinogenic mechanisms. Microbiota modulation, either by

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Semprini, Jason. "Examining the “Medicare Effect” on Distant-Stage Cancer Diagnoses by Site, Gender, and Rurality." Journal of Scientific Innovation in Medicine 6, no. 1 (2023): 4. http://dx.doi.org/10.29024/jsim.171.

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Background: Compared to cancers detected early, distant stage cancers are associated with lower survival, diminished quality of life, and higher costs. Evidence suggests that greater access to comprehensive health insurance (i.e., Medicare) improved early detection. Yet, few studies have evaluated the effect of Medicare coverage across cancers or factors influencing healthcare use. Methods: This study analyzed 35 years of population-based cancer registry data from the Surveillance Epidemiology and End Results program for eight common cancers: Oral, Digestive, Respiratory, Skin, Genital, Urinar

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Zhang, Lu, Lan-shan Huang, Gang Chen, and Zhen-bo Feng. "Potential Targets and Clinical Value of MiR-224-5p in Cancers of the Digestive Tract." Cellular Physiology and Biochemistry 44, no. 2 (2017): 682–700. http://dx.doi.org/10.1159/000485281.

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Background/Aims: MicroRNAs participate in various biological processes in malignant tumors. However, the mechanisms of miR-224-5p in digestive system cancers are not fully understood. A comprehensive investigation of the clinical value and potential targets of miR-224-5p in cancers of the digestive tract is necessary. Methods: Expression profiling data and related-prognostic data of miR-224-5p were acquired from Gene Expression Omnibus, The Cancer Genome Atlas, ArrayExpress, and published literature. The potential target mRNAs of miR-224-5p were predicted using bioinformatics methods and final

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Yaméogo, P. B., R. A. Djigemde, M. Ilboudo, A. S. Ouedraogo, and N. Zongo. "Descriptive epidemiology of colorectal cancer in Burkina Faso." African Journal of Oncology 2, no. 2 (2022): 54–57. http://dx.doi.org/10.54266/ajo.2.2.54.

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OBJECTIVE: To describe the epidemiological profile of colorectal cancers in Burkina Faso. MATERIALS AND METHODS: This was a cross-sectional and descriptive study of colorectal cancers diagnosed in all anatomy and pathology laboratories in Burkina Faso from 1988 to 2018. Age, sex, nature of the specimens, histo-genetic and histological types were studied. Comparisons were possible using Student's t test and Fisher's Khi2 test. RESULTS: In 31 years, 802 colorectal cancers were diagnosed, representing a mean annual incidence of 25.9 cases ± 7.6. These cancers represented 30.9% of all digestive ca

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Vithayathil, Mathew, Paul Carter, Siddhartha Kar, Amy M. Mason, Stephen Burgess, and Susanna C. Larsson. "Body size and composition and risk of site-specific cancers in the UK Biobank and large international consortia: A mendelian randomisation study." PLOS Medicine 18, no. 7 (2021): e1003706. http://dx.doi.org/10.1371/journal.pmed.1003706.

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Background Evidence for the impact of body size and composition on cancer risk is limited. This mendelian randomisation (MR) study investigates evidence supporting causal relationships of body mass index (BMI), fat mass index (FMI), fat-free mass index (FFMI), and height with cancer risk. Methods and findings Single nucleotide polymorphisms (SNPs) were used as instrumental variables for BMI (312 SNPs), FMI (577 SNPs), FFMI (577 SNPs), and height (293 SNPs). Associations of the genetic variants with 22 site-specific cancers and overall cancer were estimated in 367,561 individuals from the UK Bi

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Raihani, I. E., L. Bennis, I. Oussayeh, Y. Ouardi, and M. Khallouki. "Nutritional Assessment in Digestive Carcinology Surgery." SAS Journal of Medicine 11, no. 04 (2025): 352–57. https://doi.org/10.36347/sasjm.2025.v11i04.017.

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Malnutrition is a major public health concern, particularly among patients with digestive cancers, where it contributes to higher rates of postoperative complications, delayed healing, and increased morbidity. This retrospective study, conducted over six months from January to June 2024 in the visceral surgery department of Ibn Tofail Hospital, CHU Mohammed VI in Marrakech, aimed to evaluate the perioperative nutritional management of patients undergoing digestive oncologic surgery and assess adherence to current guidelines. A total of 31 patients were included, with a mean age of 59.6 years (

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Zhao, Zhou, Zhaolun Cai, Tianxiang Jiang, Junhong Han, and Bo Zhang. "Histone Chaperones and Digestive Cancer: A Review of the Literature." Cancers 14, no. 22 (2022): 5584. http://dx.doi.org/10.3390/cancers14225584.

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Background: The global burden of digestive cancer is expected to increase. Therefore, crucial for the prognosis of patients with these tumors is to identify early diagnostic markers or novel therapeutic targets. There is accumulating evidence connecting histone chaperones to the pathogenesis of digestive cancer. Histone chaperones are now broadly defined as a class of proteins that bind histones and regulate nucleosome assembly. Recent studies have demonstrated that multiple histone chaperones are aberrantly expressed and have distinct roles in digestive cancers. Objective: The purpose of this

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Liu, Fangteng, Qing Dong, and Jun Huang. "Overexpression of LncRNA PVT1 Predicts Advanced Clinicopathological Features and Serves as an Unfavorable Risk Factor for Survival of Patients with Gastrointestinal Cancers." Cellular Physiology and Biochemistry 43, no. 3 (2017): 1077–89. http://dx.doi.org/10.1159/000481719.

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Background/Aims: Many studies have reported that PVT1 played important roles in diverse cancer types. But the systematic analysis of PVT1 in gastrointestinal cancers has not been inspected. Thus, we aimed to investigate clinical value of the long noncoding RNA PVT1 (lncRNA) expression in digestive system cancers. Methods: Eligible studies were collected from a number of databases (PubMed, Web of Science, Embase, Chinese National Knowledge Infrastructure and Wanfang database). Pooled hazard ratio (HR) or odds ratio (OR) with 95 % confidence interval (95 % Cl) were applied to assess the clinical

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Bytnar, Julie A., Craig D. Shriver, and Kangmin Zhu. "Incidence rates of digestive cancers among U.S. military servicemen: Comparison with the rates in the general U.S. population." PLOS ONE 16, no. 9 (2021): e0257087. http://dx.doi.org/10.1371/journal.pone.0257087.

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Background Digestive cancers greatly contribute to the cancer burden in the United States. These cancers are more common among men and some are increasing among adults under age 50. Military population, which is dominantly male and young, and general populations differ in exposure to risk factors for these cancers. However, no studies have systematically investigated whether the incidence rates of these cancers differ between the two populations. This study aimed to compare incidence rates and trends of select digestive cancers between active-duty military and general populations in men aged 2

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Xie, Liling, Yun Song, Tengfei Lin, et al. "Association of plasma retinol levels with incident cancer risk in Chinese hypertensive adults: a nested case–control study." British Journal of Nutrition 122, no. 03 (2019): 293–300. http://dx.doi.org/10.1017/s000711451900120x.

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AbstractWe aimed to investigate the association between plasma retinol and incident cancer among Chinese hypertensive adults. We conducted a nested case–control study, including 231 patients with incident cancer and 231 matched controls during a median 4·5-year follow-up of the China Stroke Primary Prevention Trial. There was a significant, inverse association between retinol levels and digestive system cancer (per 10 μg/dl increases: OR 0·79; 95 % CI 0·69, 0·91). When compared with participants in the first quartile of retinol (&lt; 52·3 μg/dl), a significantly lower cancer risk was found

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Adrien, HODONOU Montcho, TAMOU SAMBO Bio Elie, BOBOE Jordan, SETO D. Morel, TOBOME S. Romaric, and ALLODE S. Alexandre. "Pitfalls and Diagnostic Difficulties Related to Digestive Tract Cancers in North-Benin." SAS Journal of Surgery 9, no. 1 (2023): 13–17. http://dx.doi.org/10.36347/sasjs.2023.v09i01.004.

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Introduction: Treatment of digestive cancers is not the only challenge for the practitioner over the world. Getting sound diagnosis still remains a big challenge given the pitfalls and difficulties occurring at this stage. The objective of the current study was to unravel pitfalls and difficulties related to the diagnosis of digestive cancer in northern Benin. Methodology: a cross-sectional study carried out from 2013 to 2017 at 4 hospitals in northern Benin was designed to discuss the efficiency of the current diagnosis tools and their limits for a good diagnosis. Results: In total, 141 cases

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Manfredi, Sylvain, and Antoine Drouillard. "Immune-checkpoint inhibition for digestive cancers." Lancet Oncology 18, no. 5 (2017): 561–62. http://dx.doi.org/10.1016/s1470-2045(17)30188-2.

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Thun, Michael J. "Aspirin, NSAIDs, and digestive tract cancers." Cancer and Metastasis Reviews 13, no. 3-4 (1994): 269–77. http://dx.doi.org/10.1007/bf00666097.

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