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1
Curello, Erica L. "Catestatin in heart and brain". Diss., [La Jolla] : University of California, San Diego, 2010. http://wwwlib.umi.com/cr/fullcit?p1477895.
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Thesis (M.S.)--University of California, San Diego, 2010.Title from first page of PDF file (viewed July 13, 2010). Available via ProQuest Digital Dissertations. Includes bibliographical references (leaves 38-47).
2
Geller, Stacie Ellyn. "The influence of psychosocial factors on heart transplantation". Diss., The University of Arizona, 1994. http://hdl.handle.net/10150/186642.
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This research addresses the role that psychosocial factors currently play in selection of candidates for heart transplantation, and the predictive validity of these factors to selection decisions and patient outcomes. The initial focus of this research was on what psychosocial factors are considered and how much impact they have individually and collectively on selection decisions. This investigation examined how individual members of a cardiac transplant team (University Medical Center, Tucson, Arizona) arrive at these decisions and how these individual judgments are combined into a consensual team decision. Further, in an effort to usefully standardize the psychosocial information used in patient assessments, we developed a consensus weighting formula for the whole transplant team. Our findings from the initial phase of the research indicate general agreement among team members that psychosocial factors are of some importance in screening transplant candidates. Most team members give primary attention to medical factors, though all were attentive to the influence of psychosocial factors on patient eligibility for transplant and on post-transplant adjustment. We next examined the relationship between what the team believes they are doing in selecting candidates for transplantation against empirical data from the cases the team has evaluated. However, when belief was tested against empirical evidence we find some disparity between what the team reported as important to their decision making and the actual decisions the team had made. Our results showed that team members use some, but not all, psychosocial factors in their transplant eligibility decisions. Lastly, we investigated the relationship between psychosocial factors and various patient outcomes. We investigated the extent to which outcome measures: mortality, morbidity, functional status, quality of life, patient management, and patient compliance, can be predicted by measures, including psychosocial measures, available at the time of initial evaluation. Our results indicate an association between pre-transplantation psychosocial evaluation and certain behavior aspects of transplant outcome, patient management and compliance. However, no relationship was found between psychosocial factors and medical and functional outcomes. The findings from this empirical prediction model should add to the information available to the team at the time of the pre-transplant screening decision.
3
Means, Christopher Kable. "Sphingosine 1-phosphate signaling in the heart and its role in cardioprotection". Connect to a 24 p. preview or request complete full text in PDF format. Access restricted to UC campuses, 2007. http://wwwlib.umi.com/cr/ucsd/fullcit?p3258784.
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Thesis (Ph. D.)--University of California, San Diego, 2007.Title from first page of PDF file (viewed June 8, 2007). Available via ProQuest Digital Dissertations. Vita. Includes bibliographical references.
4
Osuala, Kingsley. "Genetic and physiological contribution of adrenergic cells in heart development". Doctoral diss., University of Central Florida, 2011. http://digital.library.ucf.edu/cdm/ref/collection/ETD/id/4999.
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Bcmo-1 is a well known retinoic acid responsive gene, suggesting that the loss of adrenergic hormones in the Dbh-/- mouse heart may result in a deregulation of retinoic acid synthesis and further an alteration in the concentration of retinoic acid present in the embryonic tissue of adrenergic hormone deficient embryos. In addition, we utilized a genetic mouse model that expresses greek lower case letter beta]-galactosidase (greek lower case letter beta])-Gal) in cells capable of synthesizing epinephrine in order to identify the spatial and temporal distribution of adrenergic-derived cells in the developing heart. The model was designed so that cells capable of expressing the gene phenylethanolamine N-methyltransferase (Pnmt), which is responsible for the synthesis of epinephrine, also produce the enzyme greek lower case letter beta])-Gal as a reporter. The resulting presence of the greek lower case letter beta]-Gal enzyme can be visualized using greek lower case letter beta]-Gal substrate called XGAL, which is converted into a blue precipitate when cleaved by the greek lower case letter beta]-Gal enzyme. Evaluation of the location of these cells in the embryonic heart showed a preferential distribution at the atrioventricular sulcus at E10.5, and later at E18.5 a more widely distributed ventricular pattern was observed. In addition, the right atrium showed a cluster of XGAL positive cells (blue cells) near the region of the sinoatrial node, while the distribution of XGAL positive cells in the left atrium was quite diffuse. Interestingly, when the adult heart was examined, it was discovered that cells capable of synthesizing epinephrine (adrenergic-derived) are found predominately on the left side of the heart. This left-sided distribution appears to be non-random and non-uniform, since specific regions are consistently XGAL positive, but not every cell in each region.; The adrenergic hormones norepinephrine (NE) and epinephrine (EPI) are essential for cardiovascular development as embryos lacking NE/EPI begin to die abruptly between embryonic days 10.5 and 11.5 due to apparent cardiac failure. The objective of this research aims to elucidate the mechanism of the embryonic fatality observed in the NE/EPI deficient mouse model. Here we utilized the dopamine greek lower case letter beta]-hydroxylase knockout (Dbh-/-) mouse model, which lacks the gene and subsequent enzyme necessary for the conversion of dopamine to norepinephrine. Embryonic mouse hearts were extracted from Dbh+/+ (control) and Dbh-/- (experimental model) mice for mRNA transcript expression profiling. These studies were performed using the Affymetrix Mouse Genome 430A 2.0 Arrays and quantitative real-time RT-PCR. Gene expression data suggests a novel connection between the ability of the heart to synthesize adrenergic hormones and the gene expression of enzymes involved in the synthesis of retinoic acid. Specifically, we found a statistically significant change in transcriptional expression of the retinol binding protein-1 (Rbp-1), retinol dehydrogenase 12 (Rdh-12) and the beta carotene monooxygenase-1(Bcmo1) genes in the E10.5 Dbh-/- mouse heart. The gene expression of Rbp-1 and Rdh-12 were increased 1.4 fold and 2.1 fold on the microarray, respectively. The proteins translated from these genes play central roles in the transport and enzymatic conversion of precursor molecules in the pathway of retinoic acid biosynthesis. Additionally, we found that the expression of Bcmo-1, an enzyme responsible for the breakdown of beta carotene to the retinoic acid precursor retinal, was down regulated 2.7 fold in the Dbh-/- heart based on microarray assessment.; Whole mount and 3-dimensional reconstruction of the greek lower case letter beta]-Gal staining showed that these cells traverse the depth of the heart at the mid-ventricular and apical regions. This finding is quite interesting and may provide new knowledge about the functional and structural characteristics of the adult heart. One observation is that these cells may contribute to the cardiomyopathy known as Tako-Tsubo or "Broken Heart" syndrome. The syndrome is characterized by left ventricular dysfunction during bouts of stress. Also, of particular intrigue is the anatomical correlation of the adrenergic derived cells and the helical ventricular myocardial band (HVMB). Careful examination of the spatial and directional pattern of these cells within the myocardium suggests they contribute primarily to a specific section of the HVMB. The significance of this finding is yet to be uncovered. Taken collectively, this study has shown a novel connection between two crucial developmental signaling pathways. Adrenergic hormone and retinoic acid signaling can now be viewed as cooperative partners in the development of the embryonic heart. In addition, this study has also shown that adrenergic derived cells in the adult heart have a distinctive left-sided distribution, which is non-random, non-uniform, and shows interesting features suggesting an anatomical connection to the HVMB and a clinical association to Tako-Tsubo syndrome. These findings will appreciably contribute to the knowledge base of the scientific community.ID: 030423430; System requirements: World Wide Web browser and PDF reader.; Mode of access: World Wide Web.; Thesis (Ph.D.)--University of Central Florida, 2011.; Includes bibliographical references (p. 69-76).
Ph.D.
Doctorate
Burnett School of Biomedical Sciences
Graduate Studies
Biomedical Sciences
5
Shipp, Nancy Gillett. "Characterization of mitoxantrone cardiotoxicity in cultured heart cells". Diss., The University of Arizona, 1991. http://hdl.handle.net/10150/185453.
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The use of the anthracenedione mitoxantrone as an antitumor agent is steadily increasing. While the toxicities associated with its use are significantly less than those observed following treatment with the widely used doxorubicin, mitoxantrone cardiotoxicity is clearly a substantial clinical problem. Current information on the mechanism by which mitoxantrone causes toxicity in heart tissue is limited. Thus, the goal of these studies was to describe a model system in which mitoxantrone cardiotoxicity can be studied, and begin to describe the mechanism by which mitoxantrone exerts its cardiotoxic effect. These experiments have shown that cultured neonatal rat heart cells are an effective model system for studying mitoxantrone-induced cytotoxicity and biochemical changes in heart tissue. Cultured heart cells develop dose- and time-dependent toxicity following a short exposure to near-pharmacologically achievable drug concentrations. Furthermore, histologic changes characteristic of this drug are also observed at the light and electron microscopic level. Initial experiments aimed at defining mitoxantrone mechanism of action showed that mitoxantrone likely does not stimulate a significant production of active oxygen species, or have a specific effect on mitochondrial function. However, there is evidence to support the possibility that mitoxantrone can form a reactive intermediate in vitro. These studies have shown that covalent binding of mitoxantrone to proteins can occur under certain conditions. Mitoxantrone toxicity is lowered with the addition of ICRF-187, a metal chelating agent. Protection is not due to inactivation of mitoxantrone, decreased mitoxantrone uptake, or a delayed increase in cytosolic calcium. Similar protection is observed against doxorubicin and the oxidized form of mitoxantrone, but not against the non-hydroxylated analog of mitoxantrone, ametantrone. Furthermore, in a cell-free system, mitoxantrone can form complexes with both copper (II) and iron (III). Mitoxantrone metal binding is reversible as ICRF-187 as well as other chelators can remove the metals from these complexes. These data suggests that metal chelation is involved in the enhancement of mitoxantrone toxicity in vitro.
6
Swaney, James S. "Anti-fibrotic effects of adenylyl cyclase in the heart implications for connective tissue remodeling by cardiac fibroblasts /". Diss., Connected to a 24 p. preview or request complete full text in PDF format. Access restricted to UC campuses, 2005. http://wwwlib.umi.com/cr/ucsd/fullcit?p3190003.
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Thesis (Ph. D.)--University of California, San Diego, 2005.Title from first page of PDF file (viewed March 6, 2006). Available via ProQuest Digital Dissertations. Vita. Includes bibliographical references (p. 84-94).
7
Kim, Teddy Earl. "Study of Sestrin in eye growth regulation, lipid physiology, heart function and domain study of dSesn and mSesn1". Diss., [La Jolla] : University of California, San Diego, 2010. http://wwwlib.umi.com/cr/fullcit?p1477913.
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Thesis (M.S.)--University of California, San Diego, 2010.Title from first page of PDF file (viewed July 16, 2010). Available via ProQuest Digital Dissertations. Includes bibliographical references (leaves 46-48).
8
Hodge, Audre. "Home is where the heart is : patterns of displacement in West Indian and Black American literature". Honors in the Major Thesis, University of Central Florida, 1997. http://digital.library.ucf.edu/cdm/ref/collection/ETH/id/172.
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This item is only available in print in the UCF Libraries. If this is your Honors Thesis, you can help us make it available online for use by researchers around the world by following the instructions on the distribution consent form at http://library.ucf.edu/Systems/DigitalInitiatives/DigitalCollections/InternetDistributionConsentAgreementForm.pdf You may also contact the project coordinator, Kerri Bottorff, at kerri.bottorff@ucf.edu for more information.Bachelors
Arts and Sciences
English Literature
9
Human, Lucille. "Homocystinuria and hyperhomocysteinaemia in the Western Cape". Thesis, [S.l. : s.n.], 2002. http://dk.cput.ac.za/cgi/viewcontent.cgi?article=1020&context=td_ctech.
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Gallagher, Ann Marie. "Hormonal regulation of collagen biosynthesis and the effect of collagen deposition on the passive mechanics of the heart following myocardial infarction /". Diss., Connect to a 24 p. preview or request complete full text in PDF format. Access restricted to UC campuses, 1997. http://wwwlib.umi.com/cr/ucsd/fullcit?p9805796.
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Pham, Dominic V. "Reducing the burden on heart failure patients and hospitals with home telemonitoring". Honors in the Major Thesis, University of Central Florida, 2010. http://digital.library.ucf.edu/cdm/ref/collection/ETH/id/1478.
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This item is only available in print in the UCF Libraries. If this is your Honors Thesis, you can help us make it available online for use by researchers around the world by following the instructions on the distribution consent form at http://library.ucf.edu/Systems/DigitalInitiatives/DigitalCollections/InternetDistributionConsentAgreementForm.pdf You may also contact the project coordinator, Kerri Bottorff, at kerri.bottorff@ucf.edu for more information.Bachelors
Nursing
Nursing
12
Tadimalla, Archana. "Discovery of mesencephalic astrocyte-derived neurotrophic factor (MANF) as a secreted, endoplasmic reticulum stress response-induced gene, and its role in the heart". Diss., [La Jolla] : [San Diego] : University of California, San Diego ; San Diego State University, 2010. http://wwwlib.umi.com/cr/ucsd/fullcit?p3402843.
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Thesis (Ph. D.)--University of California, San Diego and San Diego State University, 2010.Title from first page of PDF file (viewed June 2, 2010). Available via ProQuest Digital Dissertations. Vita. Includes bibliographical references (leaves 125-136).
13
Glass, Carley E. "Genetically modified ES cells enhance cardiac repair and regeneration in the infarcted heart". Doctoral diss., University of Central Florida, 2011. http://digital.library.ucf.edu/cdm/ref/collection/ETD/id/4900.
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Hearts transplanted with TIMP-1-ES cells demonstrated a reduction in apoptosis as well as an increase in p-Akt activity compared with ES cells or culture media controls. Interstitial and vascular fibrosis was significantly decreased in the TIMP-1-ES cell group compared to controls. Furthermore, MMP-9, a key pro-fibrotic protein, was significantly reduced following TIMP-1-ES cell transplantation. Echocardiography data showed fractional shortening and ejection fraction were significantly improved in the TIMP-1-ES cell group compared with respective controls. Our data suggest that transplanted ES cells overexpressing TIMP-1 attenuate adverse myocardial remodeling and improve cardiac function compared with ES cells. Overall, our data suggest that genetic manipulation of ES cells following transplantation in the infarcted heart enhances cardiac myocyte differentiation, inhibits apoptosis and fibrosis as well as improves cardiac function.; However, no statistical significance between miR-1-ES cell and ES cell groups was observed. Finally mice receiving miR-1-ES cell transplantation post-MI had significantly improved heart function compared with respective controls. Our data suggests miR-1 drives cardiac myocyte differentiation from transplanted ES cells and inhibits apoptosis post-MI ultimately giving rise to enhanced cardiac repair, regeneration, and function. Next, we assessed the role of miR-1-ES cells in a chronic model of MI as research has shown that apoptosis occurs not only hours but months following ischemia. 4 weeks following transplantation into the infarcted myocardium, we provide evidence demonstrating reduced cardiac apoptosis in miR-1-ES cell transplanted hearts compared to respective controls. Moreover, we show significant elevation of p-Akt levels and diminished PTEN levels in hearts transplanted with miR-1-ES cells as determined by enzyme-linked immunoassays. Finally, using echocardiography, we reveal mice receiving miR-1-ES cell transplantation post-MI had significantly improved cardiac function compared with animals transplanted with ES cell and culture media. Our data suggests that miR-1, when overexpressed in transplanted ES cells, has the capacity to inhibit apoptosis long term while attenuating contractility loss. In addition to enhancing cardiac-specific donor cell differentiation, improving the efficacy by which stem cells promote cell survival and repair in the host myocardium is imperative in the pursuit of refining and optimizing stem cell therapy. To that end, we overexpressed TIMP-1, an endogenous inhibitor of apoptosis and fibrosis, in ES cells (TIMP-1-ES cells), transplanted them into infarcted myocardium, and evaluated their impact on adverse cardiac remodeling. Immunofluorescence, TUNEL staining, caspase-3 activity, ELISAs, histology, and echocardiography were used to assess apoptosis, fibrosis, and heart function.; Transplanted embryonic stem (ES) cells following myocardial infarction (MI) contribute to limited cardiac repair and regeneration with improved function. Therefore novel strategies are still needed to enhance the efficacy by which ES cells differentiate into cardiac cell types and inhibit adverse remodeling in the infarcted myocardium. Our studies evaluate whether genetic manipulation of transplanted ES cells employing miR-1, a pro-cardiac microRNA, and TIMP-1, an anti-apoptotic and anti-fibrotic protein, will enhance cardiac myocyte differentiation, inhibit native cardiac apoptosis, and reduce fibrosis in the infarcted myocardium. Furthermore, we assess levels of associated pro-(caspase-3, PTEN) and anti-(Akt) apoptotic proteins as well as a pro-fibrotic protein (MMP-9) in the post-MI and cell transplanted heart. microRNAs (miRs) have emerged as critical regulators of various physiological processes including development, differentiation, metabolism, and death. Indeed, miR-1 plays an integral role in early cardiac development in Drosophila and mice as well as mediates differentiation of cardiac myocytes in vitro. To that end, we generated ES cells overexpressing miR-1 (miR-1-ES cells), transplanted them into the infarcted myocardium, and evaluated their impact on cardiac myocyte differentiation, myocardial repair, and left ventricular dysfunction post-MI. We provide evidence demonstrating enhanced cardiac myocyte commitment of transplanted miR-1-ES cells in the mouse infarcted heart as compared to ES cell and culture media transplanted hearts. Assessment of apoptosis revealed overexpression of miR-1 in transplanted ES cells protected host myocardium from MI-induced apoptosis through activation of p-Akt and inhibition of caspase-3, PTEN, and superoxide anion production. A significant reduction in interstitial and vascular fibrosis was quantified in miR-1-ES and ES cell transplanted groups compared with control MI.ID: 030423079; System requirements: World Wide Web browser and PDF reader.; Mode of access: World Wide Web.; Thesis (Ph.D.)--University of Central Florida, 2011.; Includes bibliographical references.
Ph.D.
Doctorate
Biomedical Sciences
14
Pace, Diane Todd. "Effect of postmenopausal hormone replacement on heart rate variability". View the abstract Download the full-text PDF version, 1998. http://etd.utmem.edu/ABSTRACTS/1998-003-pace-index.html.
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Thesis (Ph.D)--University of Tennessee Health Science Center, 1998.Title from title page screen (viewed on October 17 2008). Research advisor: Kay F. Engelhardt. Document formatted into pages (xi, 162 p. : ill.). Vita. Abstract. Includes bibliographical references (p.162).
15
Merino-Chavez, Hilda. "Transplantation of Pluripotent Stem Cells Confers Cardiac Protection in DOX-Induced Heart Failure Through Notch-1 Pathway". Master's thesis, University of Central Florida, 2012. http://digital.library.ucf.edu/cdm/ref/collection/ETD/id/5436.
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Doxorubicin (DOX) is the antineoplastic drug of preference used to treat a wide variety of malignancies, with high survival rates among treated patients. However, the benefits of this drug have become less appealing due to the side effects that occur such as DOX-induced cardiomyopathy (DIC) and an increased risk of myocardial infarction (MI). Therefore, there is an urgent need to explore the therapeutic options to treat DIC. In this context, adult stem cells have been used as a source to reduce cardiomyocyte apoptosis in DIC; however, the effects of transplanted embryonic stem (ES) cells and induced pluripotent stem (iPS) cells in DIC post MI are unknown. As a result, we wanted to understand how transplanted ES and iPS cells and the factors released by them inhibit apoptosis and improve cardiac function in DIC post MI. C57BL/6 mice were divided into five groups: Sham, DOX-MI, DOX-MI+cell culture (CC) media, DOX-MI+ES cells, and DOX-MI+iPS cells. Mice were treated with DOX (12 mg/kg, cumulative dose) followed by left coronary artery ligation to induce MI. ES or iPS cells (5 x 104) were delivered into the peri-infarct region. At day 14 post-MI, echocardiography was performed, mice sacrificed, and hearts harvested for further analyses. To investigate if protective effects are provided by factors released from ES and iPS cells in DIC, we performed in vitro studies using condition media (CM) obtained from ES or iPS cells to treat DOX-induced cardiotoxicity in H9c2 cells. Our data reveal that apoptosis was significantly inhibited in the ES and iPS cell transplanted hearts as well as ESCM and iPSCM treated cells compared with the untreated controls. Furthermore, a significant increase in levels of Notch-1, Hes1, and pAkt survival protein were observed. Decreased levels of PTEN, a negative regulator of Akt pathway, along with improved heart function were also observed in the stem cell transplanted groups. In conclusion, our data show that transplantation of ES and iPS cells blunt DOX-induced apoptosis in vivo, which is associated with improved cardiac function. Moreover, decreased apoptosis in both in vitro and in vivo models is mediated by the Notch pathway.M.S.
Masters
Molecular Biology and Microbiology
Medicine
Molecular and Microbiology
16
Rydell, Erika K. "Seeing with the heart : a documentary film that explores origins of guilt among gay christians". Honors in the Major Thesis, University of Central Florida, 2009. http://digital.library.ucf.edu/cdm/ref/collection/ETH/id/1320.
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This item is only available in print in the UCF Libraries. If this is your Honors Thesis, you can help us make it available online for use by researchers around the world by following the instructions on the distribution consent form at http://library.ucf.edu/Systems/DigitalInitiatives/DigitalCollections/InternetDistributionConsentAgreementForm.pdf You may also contact the project coordinator, Kerri Bottorff, at kerri.bottorff@ucf.edu for more information.Bachelors
Arts and Humanities
History
17
Patterson, Fran Dolores. "Orthostatic blood pressure and heart rate responses within hypovolemic and normovolemic populations". Thesis, The University of Arizona, 1994. http://hdl.handle.net/10150/144633.
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A descriptive study was conducted comparing the blood pressure and heart rate responses to position change among hypovolemic and normovolemic subjects. A convenience sample of 32 men and women from an emergency room with complaints of diarrhea, vomiting, vaginal or rectal bleeding for $\ge$12 hours duration were recruited. The normovolemic group consisted of a convenience sample of 30 men and women from the community. Data analysis included a mixed design analysis of variance. Compared to supine baseline measurements, between group changes in the systolic, diastolic, and mean arterial blood pressure were not statistically significant (p $>$.05). Once the subject stood, heart rate increased statistically significant in both groups (p $<$.05). The data suggest orthostatic hypotension can be considered when the supine resting heart rate is $\ge$87 beats per minute, and if upon standing, heart rate increases by $\ge$19.33 or is $\ge$110 beats per minute. Heart rate measurements should be taken at one minute after standing.
18
Alam, Sabikha. "Cross-talk of retinoic acid and adrenergic hormone signaling may influence development of cardiac conduction and rhythmicity in utero". Honors in the Major Thesis, University of Central Florida, 2011. http://digital.library.ucf.edu/cdm/ref/collection/ETH/id/11.
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Stress hormones, adrenaline and noradrenaline, have been shown to be critical for heart development. Mice lacking dopamine greek lower case letter beta]-hydroxylase (Dbh), an enzyme responsible for synthesis of these adrenergic hormones, die during mid-gestation due to cardiac failure. Prior research showed that adrenergic cells are found within the electrical conduction system of the heart, and adrenergic deficiency leads to slowed cardiac conduction during embryogenesis. Microarray analysis of wild-type (Dbh⁺/⁺) and knockout (Dbh⁻/⁻) mouse hearts revealed significant differences in expression of retinoic acid (RA) signaling genes. RA signaling has also been shown to be critical for heart development. These data suggest that heart failure due to adrenergic deficiency may be dependent upon RA signaling. This led to the hypothesis that adrenergic hormones promote the development of the electrical conduction system through modulation of RA signaling. To test this, embryonic mouse hearts were cultured with LE 135, a RA receptor blocker. Heart rate, arrhythmic index (AI) and conduction time were measured. Under these conditions there was a marked increase in arrhythmias. Hearts treated with LE 135 showed a mean AI of 0.232±0.057 after 24 hours of treatment while when untreated had an AI of 0.083±0.028 (pless than]0.05;n=15). In contrast, there was no significant change in heart rate or conduction speed after 24 hours with or without the retinoic acid receptor blocker. To determine if adrenergic stimulus influences retinoic acid response, an established RA-sensitive reporter cell line was employed. These F9-RARE-LacZ cells were treated with forskolin (cAMP regulator) and isoproterenol (greek lower case letter beta]-agonist) to measure changes in RA signaling. Evaluation of RA signaling showed an increase in retinoic acid responsiveness when treated with an adrenergic signaling agonist.; These results suggest that proper retinoic acid signaling is essential for maintaining cardiac rhythmicity during embryonic development and adrenergic stimulation can influence this response.ID: 030476344; System requirements: World Wide Web browser and PDF reader.; Mode of access: World Wide Web.; Accepted in partial fulfillment of the requirements for honors in the major in Molecular and Microbiology.; Adviser: Steven Ebert.; Thesis (B.A.)--University of Central Florida, 2011.; Includes bibliographical references (p. 26-28).
B.S.
Bachelors
Medicine
Molecular and Microbiology
19
O'Brien, Nicole Wadsworth. "Cardiac ischemia reperfusion injury and the role of neutral sphingomyelinase /". Diss., Connect to a 24 p. preview or request complete full text in PDF format. Access restricted to UC campuses, 2003. http://wwwlib.umi.com/cr/ucsd/fullcit?p3077801.
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Lee, Shirleatha T. "The effects of glucose tolerance, hypertension, and race on heart rate variability, QT interval duration, and left ventricular hypertrophy in overweight-obese adolescents". View the abstract Download the full-text PDF version, 2009. http://etd.utmem.edu/ABSTRACTS/2009-005-Lee-index.htm.
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Thesis (Ph.D.)--University of Tennessee Health Science Center, 2009.Title from title page screen (viewed on August 27, 2009). Research advisor: Patricia A. Cowan, Ph.D. Document formatted into pages (x, 71). Vita. Abstract. Includes bibliographical references (p. 56-70).
21
Wolleben, Charles Daniel. "An Analysis of the Reversible Phosphorylation of Glycogen Synthase in Rat Heart: a Dissertation". eScholarship@UMMS, 1986. http://escholarship.umassmed.edu/gsbs_diss/288.
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The aim of this study has been to explore the site specific phosphorylation pattern of rat heart glycogen synthase paying particular attention to phosphorylations that are important to the in vivo control of enzyme activity. This problem has been approached using techniques of immuneprecipitation of 32P labeled synthase from hormonally responsive, freshly isolated adult rat cardiomyocytes.
Identification of the active subunit of rat heart glycogen synthase was accomplished by immuneprecipitating synthase from 32P-labeled cardiomyocytes and performing Western blot analysis on DEAE-cellulose fractions containing synthase activity. Using these methods, glycogen synthase activity has been localized to a protein of 88,000 daltons.
Reverse phase HPLC analysis of synthase tryptic peptides from either hormone responsive cardiomyocytes or synthase treated in vitro with cAMP-dependent protein kinase and protein phosphatase-1 (PP-1) resulted in finding six reproducible peaks of phosphopeptides. The incorporation of radioactivity into peaks 1 and 2 was associated with both the treatment of cardiomyocytes with epinephrine and the in vitro phosphorylation of rat heart synthase with cAMP-dependent protein kinase. These same two peaks are selectively dephosphorylated when cAMP-dependent kinase treated synthase is incubated with protein phosphatase-1. This dephosphorylation of peaks 1 and 2 are coincident with the conversion of synthase from the D to the I form. Peak 3 is dephosphorylated upon treatment of cardiomyocytes with insulin and hyperphosphorylated in cardiomyocytes derived from alloxan diabetic animals.
Taken together these results demonstrates the direct relationship between the phosphopeptides in peaks 1 and 2 and the inhibition of synthase activity in response to epinephrine treatment in the cell. This inhibition can be explained by the activity of cAMP-dependent protein kinase which can duplicate the intracellular, epinephrine-stimulated synthase phosphopeptide pattern. This inhibition can be relieved in vitro by protein phosphatase-1 which dephosphorylates peaks 1 and 2. The effect of insulin and alloxan diabetes is localized to peak 3 whose phosphorylation is unaffected in vitro by either cAMP-dependent protein kinase or protein phosphatase-1.
22
Burke, Michelle y University of Lethbridge Faculty of Education. "The heart of darkness : a journey into chronic sexual addiction and the quest for recovery". Thesis, Lethbridge, Alta. : University of Lethbridge, Faculty of Education, 2003, 2003. http://hdl.handle.net/10133/202.
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The processes that are involved in sexual addiction and recovery were explored in this research. A phenomenological-hermeneutic method was employed in interviewing five male recovering sexual addicts. Themes of sexual addiction and recovery were then extrapolated from the words the participants used to express their life experience. Eleven themes characterizing the addiction process emerged from the transcriptions of the participant's in-depth interviews, as well as six themes relating to recovery. It is hoped that a deeper understanding of the sexual addict's internal and external motivations for the use of sex, will be achieved by depicting several addict' experiences in an unfolding story. It is up to readers of this research to draw their own conclusions and to take what is relevant to them from the words of the sexual addicts and the researcher's interpretation of those words. There is one absolute interpretation of the participants' life experiences. This research only suggests possibilities to illuminate interpretations of the lived experiences of the five participants involved.vii, 128 leaves ; 29 cm.
23
Ninomiya, John Koichi. "Non-invasive measures of peripheral arterial disease as predictors of coronary heart and cerebrovascular disease morbidity and mortality /". Diss., Connect to a 24 p. preview or request complete full text in PDF format. Access restricted to UC campuses, 2005. http://wwwlib.umi.com/cr/ucsd/fullcit?p3189029.
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Fleming, Belinda J. "Metabolic syndrome, inflammation, heart rate variability, and fitness in obese African American Youth". View the abstract Download the full-text PDF version, 2009. http://etd.utmem.edu/ABSTRACTS/2009-026-Fleming-index.htm.
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Thesis (Ph.D.)--University of Tennessee Health Science Center, 2009.Title from title page screen (viewed on August 6, 2009). Research advisor: Patricia A. Cowan, Ph.D. Document formatted into pages (xii,112p. : ill.). Vita. Abstract. Includes bibliographical references (p. 83-111).
25
Birchell, Shannon Lloyd. "Trapping ACO applied to MRI of the Heart". UNF Digital Commons, 2019. https://digitalcommons.unf.edu/etd/862.
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The research presented here supports the ongoing need for automatic heart volume calculation through the identification of the left and right ventricles in MRI images. The need for automated heart volume calculation stems from the amount of time it takes to manually processes MRI images and required esoteric skill set. There are several methods for region detection such as Deep Neural Networks, Support Vector Machines and Ant Colony Optimization. In this research Ant Colony Optimization (ACO) will be the method of choice due to its efficiency and flexibility. There are many types of ACO algorithms using a variety of heuristics that provide advantages in different environments and knowledge domains. All ACO algorithms share a foundational attribute, a heuristic that acts in conjunction with pheromones. These heuristics can work in various ways, such as dictating dispersion or the interpretation of pheromones. In this research a novel heuristic to disperse and act on pheromone is presented. Further, ants are applied to more general problem than the normal objective of finding edges, highly qualified region detection. The reliable application of heuristic oriented algorithms is difficult in a diverse environment. Although the problem space here is limited to MRI images of the heart, there are significant difference among them: the topology of the heart is different by patient, the angle of the scans changes and the location of the heart is not known. A thorough experiment is conducted to support algorithm efficacy using randomized sampling with human subjects. It will be shown during the analysis the algorithm has both prediction power and robustness.
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Taylor, Kelly A. "Benefits of cardiac rehabilitation". Honors in the Major Thesis, University of Central Florida, 2001. http://digital.library.ucf.edu/cdm/ref/collection/ETH/id/251.
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This item is only available in print in the UCF Libraries. If this is your Honors Thesis, you can help us make it available online for use by researchers around the world by following the instructions on the distribution consent form at http://library.ucf.edu/Systems/DigitalInitiatives/DigitalCollections/InternetDistributionConsentAgreementForm.pdf You may also contact the project coordinator, Kerri Bottorff, at kerri.bottorff@ucf.edu for more information.Bachelors
Health and Public Affairs
Nursing
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Duany, John. "Predicting Cognitive Workload with Measures from Functional Near-Infrared Spectroscopy (fNIRS) and Heart Rate". Honors in the Major Thesis, University of Central Florida, 2013. http://digital.library.ucf.edu/cdm/ref/collection/ETH/id/942.
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The objective of this study was to assess low to high levels of Cognitive Workload by measuring heart rate and cortical blood flow in real-time. Four conditions were implemented into a within-subjects experimental design. Two conditions of difficulty and two conditions of trial order were used to illicit different levels of workload which will be analyzed with psychophysiological equipment. Functional Near-Infrared Spectroscopy (fNIRS) has become more prominent for measuring the blood oxygenation levels in the prefrontal cortex of individuals operating in hazardous work environments, students with learning disabilities, and in research for military training. This is due to the fNIR device being highly mobile, inexpensive, and able to produce a high-spatial resolution of the dorsolateral prefrontal cortex during executive functioning. Heart Rate will be measured by an Electrocardiogram, which will be used in concordance with fNIR oxygenation levels to predict if an individual is in a condition that produces low or high mental workload. Successfully utilizing heart rate and blood oxygenation data as predictors of cognitive workload may validate implementing multiple physiological devices together in real-time and may be a more accurate solution for preventing excessive workload.B.S.
Bachelors
Sciences
Psychology
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Walker, Claudette. "Effects of the Use of a Heart Failure Diary on Self-Care and Quality of Life". UNF Digital Commons, 2011. http://digitalcommons.unf.edu/etd/65.
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Heart Failure is a growing and costly problem in the United States. There have been advancements in medical therapy, but unfortunately patients continue to have frequent exacerbations and hospital readmissions. The reason for this may be inadequate Heart Failure self-care, which is the most important aspect of disease management. Literature strongly encourages self-care, but there is minimal research focusing on the use of a Heart Failure diary. The study was a one group pretest/posttest design. The intervention included individualized education, provision of the Heart Failure Diary, and weekly follow-up for a total of four weeks. The Heart Failure Diary was developed specifically for this study for recording daily self-care maintenance activities which includes weight monitoring, fluid intake, salt intake, swelling, shortness of breath, and medication adherence. In order to determine the effects of using the diary on self-care and quality of life, the Self-Care of Heart Failure Index (SCHFI) and Minnesota Living with Heart Failure Questionnaire (MLHFQ) responses were compared pre and post intervention. The difference between the SCHFI pretest-posttest scores demonstrated a non-significant improvement in self-care maintenance, n = 14, 2.616 (12.942), SE = 3.459, p = .463, t = - .756, 95% CI [-10.089, 4.856]. The difference between the MLHFQ pretest-posttest scores demonstrated a non-significant improvement in quality of life, n = 14, -5.500 (18.851), SE = 5.038, p = .295, t = 1.092, 95% CI [-5.384, 16.384]. The effect size of the SCHFI, d = .20, and the MLHFQ, d = .29, are both small and most likely due to the small sample size. The study concluded that using the diary did not have a statistically significant effect on the self-care or quality of life of these patients with heart failure.
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Cao, Fei. "Chlamydia pneumoniae, toll-like receptors and pathogenesis of atherosclerotic heart disease". View the abstract Download the full-text PDF version (on campus access only), 2007. http://etd.utmem.edu/ABSTRACTS/2007-022-Cao-index.html.
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Thesis (Ph.D. )--University of Tennessee Health Science Center, 2007.Title from title page screen (viewed on May 16, 2008 ). Research advisor: Gerald I. Byrne, Ph.D. Document formatted into pages (xi, 114 p. : ill.). Vita. Abstract. Includes bibliographical references (p. 65-107).
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Tarassova, Inna. "Factors associated with recovery from cardiac surgery in female patients". Honors in the Major Thesis, University of Central Florida, 2001. http://digital.library.ucf.edu/cdm/ref/collection/ETH/id/254.
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This item is only available in print in the UCF Libraries. If this is your Honors Thesis, you can help us make it available online for use by researchers around the world by following the instructions on the distribution consent form at http://library.ucf.edu/Systems/DigitalInitiatives/DigitalCollections/InternetDistributionConsentAgreementForm.pdf You may also contact the project coordinator, Kerri Bottorff, at kerri.bottorff@ucf.edu for more information.Bachelors
Health and Public Affairs
Nursing
31
Macharia, Muiruri. "Modulation of oxidative stress biomarkers by rooibos in adults at risk of developing coronary heart disease /". [S.l. : s.n.], 2008. http://dk.cput.ac.za/cgi/viewcontent.cgi?article=1024&context=td_cput.
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Gwadry-Sridhar, Femida Guyatt Gordon Henry. "Educating patients with heart failure /". [Hamilton, Ont.] : McMaster University, 2005.
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Williams, Mary. "Life on hold: A theory of spouse response to the waiting period prior to heart transplantation". Diss., The University of Arizona, 1991. http://hdl.handle.net/10150/185731.
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The purpose of this study was to generate a grounded theory explaining the social and psychological processes used by spouses during the waiting period prior to heart transplantation. Theory discovery was accomplished using the grounded theory methodology. Life on Hold was identified as the basic social psychological process generated from the data that explains the responses of spouses during the waiting period prior to heart transplantation. Life on Hold is the process of "tabling" life's activities for an indefinite period of time in order to devote one's life to another person(s) or event. Spouses of heart transplant candidates set aside life's activities and focus all thoughts, actions, and energy on maintaining the life of the candidate until a donor heart is obtained. The process consists of two stages: Freeing Self and Making Life the Transplant. The theory provides a basis for the development of relevant interventions to assist family members to cope with the uncertainty and stress of the transplant experience.
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Williams, Cynthia. "Home Care Quality Effects of Remote Monitoring". Doctoral diss., University of Central Florida, 2014. http://digital.library.ucf.edu/cdm/ref/collection/ETD/id/6383.
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Despite concerted efforts to decrease costs and increase public health, the embattled U.S. health care system continues to struggle to alleviate these widespread issues. Because the problem of hospital utilizations among patients with heart failure is posited to increase as the population ages, innovative methodologies need to be explored to mitigate adverse events. Remote monitoring harnesses the strength of advanced information and communication technology to affect positive changes in health care quality and cost. By reaching across geographical boundaries, remote monitoring may support increased access to less costly services and improve the quality of home health care.
The purpose of the study was to examine the home care quality effects of remote monitoring technology in patients with heart failure and to provide an economic justification for its adoption and diffusion. It compared remote monitoring as a potential intervention strategy to a standard no-intervention group (without remote monitoring). Specifically, it analyzed remote monitoring as a viable strategy to decrease hospital readmissions and emergency department visits. It also compared the cost of remote monitoring against the current standard-of-care.
The theoretical framework of Donabedian's Quality Model was used in the evaluation of remote monitoring. A retrospective posttest only, case control study design was used to test the degree which remote monitoring was effective in promoting health care quality (hospital readmissions and decreased emergency department visits). Retrospective chart reviews were performed using electronic medical records (EMR). Analysis of Variance, Path Analysis, Automatic Interaction Detector Analysis (Dtreg), and Cost Outcomes Ratio were used to test the hypotheses and validate the proposed theoretical model.
No significant difference was noted in remote monitoring and usual care groups. Results suggested that remote monitoring does not statistically lead to a decrease in heart failure-related hospital readmissions and all-cause emergency department visits. Results of the cost ratio analysis suggested that there was no statistically significant difference in the net income between usual care and remote monitoring; however, data suggest that there were significant increases in cost and intensity of nursing utilization for the remote monitoring intervention. The Automatic Interaction Detector Analysis showed that the unfavorable results in hospital readmissions were due to a decrease in collaborative care and patient education prior to the recommendation for hospitalization.
The role of nursing care, whether in hospital or community-based care, in heart failure management is critical to quality outcomes. As the field continues to consider the use of technology in health care, decision makers should think through the process of patient care such that preventable hospital readmissions are decreased and patients received quality care.Ph.D.
Doctorate
Health and Public Affairs
Public Affairs; Health Services Management and Research Track
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Steyn, Jan. "The assessment of echocardiographic and tissue Doppler profiles of asymptomatic follow-up patients in cardiology practice". Thesis, Bloemfontein : Central University of Technology, Free State, 2010. http://hdl.handle.net/11462/128.
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Thesis (M. Tech.) -- Central University of Technology, Free State, 2010This main aim of this study was to assess patients in a general cardiology practice in order to determine the systolic and diastolic profiles of these patients. The aim was also to determine what effect life style and risk factors may have on the echocardiographic variables measured during such an examination. The specific aim of this study was the importance of not only examining the systolic function but the necessity to also examine the diastolic profile of patients. Life-style plays an important role, with the main culprit being obesity. Obesity was the single most important factor that affected the diastolic profile of patients seen in this study. With obesity a combination of other risk factors related to obesity was observed. Most abnormalities found due to these risk factors were associated with diastolic changes in the left ventricle. Echocardiography is routinely used in daily practice, but the diagnostic value of this tool can be enhanced if proper analyses of the systolic as well as the diastolic profiles are determined. Many cardiologists only measure the systolic function of the heart as an indication of the well- being of the left ventricle, although in this study it was proven that systolic function did not alter with ageing or with changes in the risk profile. Hundred-and-twelve patients, divided into three age groups, were evaluated in this study. Both systolic and diastolic variables were measured and analysed for abnormalities. None of these patients had systolic function abnormalities, although they had detectable anatomic changes due to ageing, obesity and hypertension. Several abnormalities were found on the diastolic profile of these patients. Muscle thickness increased due to obesity and hypertension and even with ageing, but with no significant abnormalities in the systolic function of the heart. There was a slight increase in the circumferential shortening of the left ventricle and that both the septal and longitudinal functions decreased with ageing. It is noteworthy that even where the systolic function remained normal in ageing subjects, their diastolic profiles changed significantly. Assessment of left ventricular function required a meticulous and systematic approach. In this study forty- one percent of patients visiting this general practice had abnormalities of their diastolic function although their systolic function was normal. It was found that with ageing, especially in the older age group, important abnormalities occur in their diastolic profile. The most common changes were that the E- peak velocity decreased and that the Apeak velocity of the trans-mitral flow increased. It seemed that passive filling decreased with ageing but that active filling increased simultaneously, causing the cardiac output to remain constant in older subjects. This is important to know because diseases affecting the atrium may have a profound effect on the cardiac output of older patients, even if they have normal systolic function, (due to the decreased passive filling they need their active filling or atrial contraction to support a normal cardiac output). An important marker will be to look at the ratio of the E/A- velocities in older patients to determine the ratio of active against passive filling. Other than that, a relatively new tool in echocardiography called tissue Doppler was used to determine what happened to the muscle with ageing. Here it was demonstrated that the different layers of the left ventricle acted differently with ageing. Results showed that the longitudinal fibres weakened with ageing although the circumferential fibres remained unchanged or even strengthened with ageing. It was apparent in this study that the traditional use of only systolic function may not be adequate when evaluating relative asymptomatic patients presenting at a general cardiology practice. It is important to also evaluate the diastolic profiles of these patients in order to scientifically quantify their heart health, even in asymptomatic patients. It is important to routinely evaluate the diastolic profile of patients so that early detection of these diastolic variables can be detected and timely consideration for its treatment can be given by their cardiologist. It is also important to take note of the significance of the obesity problem and the effect it has on the heart’s health. In conclusion, this study emphasizes the importance of the echocardiographic evaluation of diastolic cardiac function in addition to routine systolic evaluation in asymptomatic patients. This will enable the clinician to detect abnormalities early and tailor therapy accordingly. Lifestyle related risk factors, especially obesity, also have significant effects on diastolic cardiac function.
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Scott, Samantha L. "Is Selective Mutism an Emotion Regulation Strategy for Children with Social Phobia? A Single Case Design Investigation". Doctoral diss., University of Central Florida, 2012. http://digital.library.ucf.edu/cdm/ref/collection/ETD/id/5489.
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To determine whether children with selective mutism (SM) withhold speech to regulate their emotional arousal and decrease automatic distress, the current study examines the behavioral and physiological responses of children with SM in comparison to children with social phobia (SP) and children with no psychiatric disorder (TD) as they participate in two social situations. A single case design strategy is used to compare behavioral and physiological responses both within and across groups. Examining the temporal sequencing of behaviors and physiology provides a direct test of the utility of emotion regulation theory as it pertains to children with social phobia/selective mutism. The results indicate that children with SM show elevated arousal and emotional reactivity across all interaction segments relative to other children. Unique affective, behavioral and physiological responses occur between and within groups in relation to situational demands. The temporal sequencing of behavioral and physiological responses suggests that behavioral deficits may be related to underutilized and/or deficient physiological response systems and that not speaking represents a primitive avoidance strategy by children with SM to regulate extreme physiological arousal.ID: 031001331; System requirements: World Wide Web browser and PDF reader.; Mode of access: World Wide Web.; Adviser: Deborah C. Beidel.; Title from PDF title page (viewed April 9, 2013).; Thesis (Ph.D.)--University of Central Florida, 2012.; Includes bibliographical references (p. 79-90).
Ph.D.
Doctorate
Psychology
Sciences
Psychology; Clinical Psychology
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Potgieter, Helena Davina. "Inflammatory marker comparison between patients with acute coronary syndrome undergoing on-pump versus off-pump coronary artery bypass graft surgery". Thesis, Bloemfontein : Central University of Technology, Free State, 2010. http://hdl.handle.net/11462/126.
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Thesis (M. Tech. (Biomed. Tech.)) -- Central University of Technology, Free State, 2010The World Health Organization (WHO) has warned in 2005 that: “Coronary heart disease is now one of the leading causes of death worldwide. It is on the rise and has become a true pandemic that respects no borders” (WHO, 2005). The Heart and Stroke Foundation of South Africa more specifically estimates that approximately 33 (thirty‐three) people per day will die of a heart attack in South Africa. Despite the already high death toll resulting from AIDS in South Africa, death from a chronic disease, also including heart disease, will increase from 565 deaths per day in the year 2000, to 666 deaths per day by 2010 (Steyn, 2007). Acute coronary syndrome (ACS) is an ‘umbrella term’ describing a heterogeneous spectrum of clinical symptoms compatible with acute myocardial ischaemia (Monaco, Mathur, Martin, 2005; ACC/AHA, 2007) and an ongoing inflammatory process resulting from atherosclerosis. ACS can either be treated medically (pharmacological treatment), by percutaneous coronary intervention (PCI), or by performing coronary artery bypass graft (CABG) surgery either through on‐pump or offpump CABG surgery. By treating the ACS patient by means of CABG surgery, an inflammatory response is further triggered on top of the already existing inflammation resulting from atherosclerosis. This leads to a systemic inflammatory response (SIR), which may eventually lead to systemic inflammatory response syndrome (SIRS). This study focuses on the inflammatory response initiated by the CABG technique applied during the revascularisation of the ACS patient. Many past studies compared on‐pump and off‐pump CABG surgery, arguing not only the advantages and disadvantages of these surgeries, but also the outcomes regarding SIRS. Both types of surgery are associated with an inflammatory response resulting from tissue trauma and the use of the extracorporeal circulation (EC) in CABG surgery (Quaniers, Leruth, Albert, Limet, Defraigne, 2006). This non‐randomised, observational study primarily aimed to assess and compare the pre‐ and the post‐operative inflammatory markers between (n=60) patients with ACS undergoing either on‐pump CABG (n=30) or off‐pump CABG surgery (n=30). A secondary objective was to ascertain whether a correlation exists between the pre‐operative risk factors, the surgical procedure and the pre‐ and post‐operative inflammatory markers. Three inflammatory markers ‐ full blood count (FBC), procalcitonin (PCT) and C‐reactive protein (CRP) ‐ were analysed employing normal routine laboratory analysis. Interleukin‐6 (IL‐6) and tumour necrosis factor alpha (TNF‐α) were analysed using an enzyme amplified sensitivity immunoassay (EASI) method. The inflammatory markers were analysed pre‐operatively (baseline) and post‐operatively and at different time intervals (24, 48, 72, 96 and 120 hours post‐operatively). Pre‐operatively, all the leucocytes were already elevated in both CABG groups, as could be expected in patients with ACS resulting from the already existing atherosclerotic process and the consequent pre‐operative existing inflammatory response. A significant pre‐operative difference was moreover detected in respect of the lymphocytes between the two CABG groups (p=0.03024). A significant post‐operative difference was also detected between the two CABG groups. The following significantly elevated levels were detected in the on‐pump CABG surgical group: for WCC at 24 hours (p=0.00761), 48 hours (p=0.01520) and 72 hours (p=0.00004); for neutrophils at 24 hours (p=0.17422), 96 hours (p=0.18611) and 120 hours (p=0.12872); for lymphocytes at 48 hours (p=0.04829) and at 96 hours (p=0.01982); and, for PCT at 24 hours (p=0.00811), 48 hours (p=0.00966) and 72 hours (p=0.01823) . However, measurable values of IL‐6 levels were found to be higher in the off‐pump CABG surgical group, with significant differences manifesting between the two CABG groups at 96 hours (p=0.05352) and 120 hours (p=0.09729). No differences between the two groups could be demonstrated for eosinophils, basophils, monocytes, CRP and TNF‐α. In conclusion: despite the demonstrable inflammatory responses in both CABG groups, no difference in clinical outcomes was observed. The inflammatory responses evoked by on‐pump and off‐pump CABG procedures will, for some time to come, remain an area of interest for future research, but they are certainly not the only factors to have a bearing on surgical outcomes. The impact of intraoperative events needs to be elucidated further ‐ and in more detail ‐ in order to attempt to determine the relationship of these events on the extent of inflammatory responses and clinical outcomes, irrespective of whether the procedure is performed with or without cardiopulmonary bypass.
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Liebenberg, Liebenberg. "Evaluation of near-infrared spectroscopy in patients with acute coronary syndrome undergoing on and off-pump coronary artery bypass graft surgery". Thesis, Bloemfontein : Central University of Technology, Free State, 2012. http://hdl.handle.net/11462/161.
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Thesis (M. Tech. (Clinical technology)) - Central University of technology, Free State, 2012The objective of this study was to investigate whether intra-operative regional cerebral tissue oxygen saturation (NIRS) and hemodynamic monitoring in patients with Acute Coronary syndrome (ACS) during coronary bypass graft surgery (CABG on-pump vs. off-pump) can predict clinical outcomes and complications. Data from 60 CABG patients (30 on-pump and 30 off-pump) were analyzed. The regional cerebral tissue oxygen saturation was monitored by using near-infrared spectroscopy (NIRS). The sensors were positioned in the middle of the patient's forehead and the cables were connected to the sensors and to the INVOS 5100C® Oximeter. According to NIRS values obtained, patients were subdivided into two groups. Patients in Group 1 had absolute NIRS values more than 50 or less than a 20% drop from the baseline value. Patients in Group 2 had absolute NIRS values of less than 50 or a drop of more than 20% from the baseline value. The lowest value recorded during the procedure was recorded for this purpose, irrespective of the time this value was obtained. Intra-operative hemodynamic monitoring was captured by a computer software program (Supplier Datex Ohmeda, South Africa). In order to describe surgical outcomes several parameters were analysed and compared. This included a Pre- and Post-operative Mini-Mental state examination that was performed to identify neurological outcomes or impairment. The NIRS values and trends in relation to renal function (U&E and creatinine, urine output, and urine electrolytes), as well as clinical outcomes were analyzed post-operatively for the different groups. Clinical outcomes were described using the Society of Thoracic Surgeons Database (STS database) data fields, and specifically the recording of complications. The overall clinical outcomes were analysed between the on-pump and off-pump groups as well as the NIRS results between the two groups. In order to elucidate the predictive role of NIRS the patients were divided into groups with either impaired /reduced NIRS values or acceptable NIRS values according to published results where a reduction of more than 20% from baseline or absolute values of less than 50 were associated with inferior outcomes. Finally, the predictive value of NIRS was evaluated within the on- and then the off-pump groups. In this analysis the outcomes of patients with reduced NIRS values was compared to those of patients with acceptable NIRS values. The study demonstrated that by far the majority of patients with reduced cerebral flow/oxygen delivery as reflected in cerebral NIRS, had on-pump CABG procedures (84% fell in risk group 2). It also showed that a NIRS reduction of more than 20 % from baseline and values of less than 50, has an impact on post–operative renal function. Monitoring of cerebral oximetry intra-operatively by using near-infrared spectroscopy during cardiac surgery (especially in on-pump cardiac surgery patients) allows the perfusionist and anaesthesiologist to detect cerebral desaturation and to intervene as necessary. This study also showed a tendency towards less renal function impairment in patients with absolute NIRS values > 50 or where there was < 20% drop from baseline. It is probably important to consider studying the time spend below 50 or a drop of more than 20% from baseline NIRS values, or the “area under the curve” as a specific factor contributing to the increased risk for post-operative complications applied on an increased study population. The study supports the routine use of NIRS as a non-invasive trend monitor of cerebral saturation and certainly initiated interventions by both anaesthetic and perfusion staff which contributed to excellent clinical outcomes in this research study.
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Hudson, Erik Mark. "A Portable Computer System for Recording Heart Sounds and Data Modeling Using a Backpropagation Neural Network". UNF Digital Commons, 1995. http://digitalcommons.unf.edu/etd/158.
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Cardiac auscultation is the primary tool used by cardiologists to diagnose heart problems. Although effective, auscultation is limited by the effectiveness of human hearing. Digital sound technology and the pattern classification ability of neural networks may offer improvements in this area. Digital sound technology is now widely available on personal computers in the form of sound cards. A good deal of research over the last fifteen years has shown that neural networks can excel in diagnostic problem solving. To date, most research involving cardiology and neural networks has focussed on ECG pattern classification. This thesis explores the prospects of recording heart sounds in Wave format and extracting information from the Wave file for use with a backpropagation neural network in order to classify heart patterns.
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Balakrishnan, Meenakshi Puthucode. "Studies on a novel human cardiospecific transcription factor and its involvement in Omi/HtrA2 mediated cell death". Doctoral diss., University of Central Florida, 2010. http://digital.library.ucf.edu/cdm/ref/collection/ETD/id/4649.
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Omi/HtrA2 is a mitochondrial serine protease that is known to translocate to the cytoplasm upon induction of apoptosis and to activate caspase-dependent and caspase-independent cell death. The molecular mechanism of Omi/HtrA2's function is not clear but involves degradation of specific substrates. These substrates include cytoplasmic, mitochondrial, as well as nuclear proteins. We have pubmedisolated a new Omi/HtrA2 interactor, the THAP5 protein. THAP5 is a fifth member of a large family of transcription factors that are involved in cell proliferation, apoptosis, cell cycle control, chromosome segregation, chromatin modification and transcriptional regulation. THAP5 is an approximately 50kDa nuclear protein, with a restricted pattern of expression. Furthermore, there is no mouse or rat homolog for this protein. THAP5 mRNA is highly expressed in the human heart but some expression is also seen in the brain and skeletal muscle. The normal function of THAP5 in the heart or heart disease is unknown. THAP5 protein level is significantly reduced in the myocardial infarction (MI) area in the heart of patients with coronary artery disease (CAD). This part of the heart sustains most of the cellular damage and apoptosis. Our data clearly show that THAP5 is a specific substrate of the proapoptotic Omi/HtrA2 protease and is cleaved and removed during cell death. The molecular mechanism of THAP5's function is unclear. THAP5 can bind to a specific DNA sequence and repress transcription of a reporter gene. Our work suggests that THAP5 is a tissue specific transcriptional repressor that plays an important role in the normal function of the human heart as well as in the development of heart disease.ID: 029050522; System requirements: World Wide Web browser and PDF reader.; Mode of access: World Wide Web.; Thesis (Ph.D.)--University of Central Florida, 2010.; Includes bibliographical references (p. 68-79).
Ph.D.
Doctorate
Burnett School of Biomedical Sciences
Medicine
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Ceballos, Andres. "A multiscale model of the neonatal circulatory system following Hybrid Norwood palliation". Master's thesis, University of Central Florida, 2011. http://digital.library.ucf.edu/cdm/ref/collection/ETD/id/4866.
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A system of 32 first-order differential equations is formulated and solved for the LP model using a fourth-order adaptive Runge-Kutta solver. The output pressure and flow waveforms obtained from the LP model are imposed as boundary conditions on the CFD model. Coupling of the two models is done through an iterative process where the parameters in the LP model are adjusted to match the CFD solution. The CFD model domain is a representative HLHS anatomy of an infant after undergoing the Hybrid Norwood procedure and is comprised of the neo-aorta, pulmonary roots, aortic arch with branching arteries, and pulmonary arteries. The flow field is solved over several cardiac cycles using an implicit-unsteady RANS equation solver with the k-epsilon turbulence model.; Hypoplastic left heart syndrome (HLHS) is a complex cardiac malformation in neonates suffering from congenital heart disease and occurs in nearly 1 per 5000 births. HLHS is uniformly fatal within the first hours or days after birth as the severely malformed anatomies of the left ventricle, mitral and aortic valves, and ascending aorta are not compatible with life. The regularly implemented treatment, the Norwood operation, is a complex open heart procedure that attempts to establish univentricular circulation by removing the atrial septum (communicating the right and left ventricle), reconstructing the malformed aortic arch, and connecting the main pulmonary artery into the reconstructed arch to allow direct perfusion from the right ventricle into the systemic circulation. A relatively new treatment being utilized, the Hybrid Norwood procedure, involves a less invasive strategy to establish univentricular circulation that avoids a cardiopulmonary bypass (heart-lung machine), deliberate cardiac arrest, and circulatory arrest of the patient during the procedure. The resulting systemic-pulmonary circulation is unconventional; blood is pumped simultaneously and in parallel to the systemic and pulmonary arteries after the procedure. Cardiac surgeons are deeply interested in understanding the global and local hemodynamics of this anatomical configuration. To this end, a multiscale model of the entire circulatory system was developed utilizing an electrical lumped parameter model for the peripheral or distal circulation coupled with a 3D Computational Fluid Dynamics (CFD) model to understand the local hemodynamics. The lumped parameter (LP) model is mainly a closed loop circuit comprised of RLC compartments that model cardiac function as well as the viscous drag, flow inertia, and compliance of the different arterial and venous beds in the body.ID: 030423155; System requirements: World Wide Web browser and PDF reader.; Mode of access: World Wide Web.; Thesis (M.S.)--University of Central Florida, 2011.; Includes bibliographical references (p. 59-61).
M.S.
Masters
Mechanical, Materials, and Aerospace Engineering
Engineering and Computer Science
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Evangelista, Kimberly. "Factors Associated with Depression in Adult Cardiac Surgery Patients". Honors in the Major Thesis, University of Central Florida, 2007. http://digital.library.ucf.edu/cdm/ref/collection/ETH/id/1163.
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This item is only available in print in the UCF Libraries. If this is your Honors Thesis, you can help us make it available online for use by researchers around the world by following the instructions on the distribution consent form at http://library.ucf.edu/Systems/DigitalInitiatives/DigitalCollections/InternetDistributionConsentAgreementForm.pdf You may also contact the project coordinator, Kerri Bottorff, at kerri.bottorff@ucf.edu for more information.Bachelors
Nursing
Nursing
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Jacobs, Salomi. "Referencing echocardiographic measurements for premature and low-birth weight infants". Thesis, Bloemfontein : Central University of Technology, Free State, 2012. http://hdl.handle.net/11462/212.
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Thesis (M. Tech. (Clinical Technology)) -- Central University of technology, Free State, 2012Introduction: Reference ranges for cardiac measurement are available for adults, children and term infants but the same cannot be said for preterm or small for gestational age (SGA) infants surviving as a result of modern intensive care units. No published data of reference ranges for preterm infants exists for the South African population. Infants with congenital heart disease are twice as likely to be small for their gestational age and these reference ranges may affect clinical management decisions, therapeutic response and prognosis of these neonates. The aim was thus to establish reference ranges for cardiac dimensions and functional values for preterm and low birth weight infants for central South Africa and compare them with international standards. Methods: A total of 290 infants of less than 34 weeks of age and weighing less than 2500g at birth were examined during a twelve month period by echocardiography during the first 0-28 days of life. The study assessed normative cardiac measurements divided in M-Mode, 2-D and functional measurement for these infants in 3 weight groups. Exclusion criteria were applied to any condition affecting the size and functionality of the cardiac system. The following dimensions were measured: Standard M-Mode values for the left ventricle, 2D measurements of valve mitral and tricuspid orifices, as well as functional assessments including Shortening fraction (SF %), Ejection fraction (EF %), and Muscle performance Index (MPI)-index of the Left and Right ventricle. Measurements were done by the leading edge methodology following the ASE recommendations. A longitudinal study was also done to examine changes in these indices over the first month- on day 14 and day 28 of life. Interobserver differences were calculated for the variability between measurements of a single scan- 25 babies were re-measured and produced good repeatability. Results: 290 infants were included to produce Referance ranges of measurements (means and standard deviations) for 3 weight groups namely: <0.999g, 1000-1499g, and 1500g – 2500g. The gestational age’s ranges between 26-38 weeks with a median of 31 weeks, gender distribution was almost equal with a slight female preponderance. Body surface area ranged from a minimum from 0.076 m² and a maximum of 0.184 m², the body weight ranged between a minimum of 690g and a maximum of 2500g with a median of 1360g. Discussion: The left ventricular diastolic and systolic, interventricular septum, posterior wall, aortic and left atrium dimensions showed a proportionate increase in diameter with an increase in body weight There were no differences in cardiac dimensions between Small for Gestational age” (SGA) versus “Average for Gestational age” (AGA). Gender and race played no role in any functional measurements or with the cardiac sizes. Weight correlated well with BSA and the data suggest that weight only can be used to develop tables for clinical use. Cardiac chambers increased with BSA and weight and functional measurements stayed the same throughout the weight groups. Systolic and global functions were remarkably similar and constant throughout weight categories. . The longitudinal study also confirmed that the values are applicable to all low birth weight infants up to 28 days of age. Differences existed between some of the average South African infant’s cardiac chambers and international values. The Inter Ventricular Septum (IVS) and Posterior Wall (PW) measured thicker and the Left Atrium larger. This could be due to numerous factors that should be investigated further. Conclusion: The study emphasized the profound effect of growth and weight gain on the cardiac structure and that population specific reference values should therefore be developed and used.
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Saxena, Ankur. "Cell migration and survival pathways in cardiac development and disease". Access to abstract only; dissertation is embargoed until after 12/20/2006, 2005. http://www4.utsouthwestern.edu/library/ETD/etdDetails.cfm?etdID=138.
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Schroeder, Samantha. "The nature of love a phenomenological approach". Honors in the Major Thesis, University of Central Florida, 2012. http://digital.library.ucf.edu/cdm/ref/collection/ETH/id/615.
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As I hope to show, a philosophical study of love is highly relevant today, since the sciences have not adequately answered the perennial question: What is love?; Since the time of Socrates, the idea of love and the conception of the human heart have been devalued by thinkers who, by definition, are known as "lovers of wisdom." Considered pejoratively as "the passions," the subject of emotion was deemed inferior to thought centered upon the human faculty of reason. Many studies in the sciences, from biology to psychology, claim to have pointed us to the source of the human experience of love--but do they help us to understand love properly? In order to provide a full consideration of love in my philosophical research, I will focus my analysis on love under the philosophical lens of phenomenology. Known as the study of firsthand human experience, phenomenology became the influential school of thought for many German philosophers in the early twentieth century. My research will closely examine the writings of Max Scheler, Dietrich von Hildebrand, and Jean-Luc Marion within the context of this tradition. Moving from a justification of love in philosophy to the topic of self-love, I hope to define effectively what it means to love another. I shall also attempt to disambiguate the common assumptions regarding the nature of love. Is there a fundamental difference between the phenomenon of "falling in love" and of love itself? I question whether love, in its essence, is defined by the element of choice--of a willful emotional giving of oneself to another--and whether it can be distinguished from a passive feeling and an active loving will. I aim to bring the human affective sphere into the full light of philosophical inquiry, considering whether love is a moral act of the will that involves a total participation of the self--in mind, body, and spirit. Love is arguably the most powerful of the human emotions, one that elevates the human sphere of emotions and the ethical existence beyond simple desire.B.A.
Bachelors
Arts and Humanities
Philosophy
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Owen, Ashley Ellen. "Evaluation of differences in depression, defensiveness, social support, and coping between acute and chronic CHD patients hospitalized for myocardial infarction or unstable angina". [Tampa, Fla.] : University of South Florida, 2003. http://purl.fcla.edu/fcla/etd/SFE0000066.
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Rariden, Brandi Scot. "Sedentary Time and the Cumulative Risk of Preserved and Reduced Ejection Fraction Heart Failure: from the Multi-Ethnic Study of Atherosclerosis". UNF Digital Commons, 2018. https://digitalcommons.unf.edu/etd/792.
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ABSTRACT
Purpose: The purpose of this study was to examine the relationship between self-reported sedentary time (ST) and the cumulative risk of preserved ejection fraction heart failure (HFpEF) and reduced ejection fraction heart failure (HFrEF) using a diverse cohort of U.S. adults 45-84 years of age.
Methods: Using data from the Multi-Ethnic Study of Atherosclerosis (MESA), we identified 6,814 subjects (52.9% female). All were free of baseline cardiovascular disease. Cox regression was used to calculate the hazard ratios (HR) associated with baseline ST and risk of overall heart failure (HF), HFpEF, and HFrEF. Weekly self-reported ST was dichotomized based on the 75th percentile (1,890 min/wk).
Results: During an average of 11.2 years of follow-up there were 178 first incident HF diagnoses; 74 HFpEF, 69 HFrEF and 35 with unknown EF. Baseline ST >1,890 min/wk was significantly associated with an increased risk of HFpEF (HR [95% CI]; 1.87 [1.13 – 3.09], p= 0.01), but not HFrEF (HR [95% CI]; 1.30 [0.78 – 2.15], p= 0.32). The relationship with HFpEF remained significant in separate fully adjusted models including either waist circumference (HR [95% CI]; 2.16 [1.23 – 3.78], p < 0.01) or body mass index (HR [95% CI]; 2.17 [1.24 – 3.80], p < 0.01). Additionally, every 60 minute increase in weekly ST was associated with a significant 3% increased risk of HFpEF (HR [95% CI]; 1.03 [1.01 – 1.05], p < 0.01).
Conclusions: Sedentary time > 1,890 min/wk (~4.5 h/d) is a significant independent predictor of HFpEF, but not HFrEF.
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Floyd, Shelley Ann. "Neuropsychological, Cognitive and Physiological Implications of Barefoot Running on Working Memory". UNF Digital Commons, 2015. http://digitalcommons.unf.edu/etd/556.
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The aim of the present study was to compare the effects of barefoot versus shod running on working memory. I recruited exercise science students from the University of North Florida who exercised recreationally. Participants ran both barefoot and shod while hitting targets (poker chips) on a running track and without targets. I measured working memory using backward digit recall and also recorded participants’ heart rate, speed, and target accuracy. The main finding from this study was that working memory performance increased in the barefoot condition when participants hit targets (poker chips). This result supports the idea that additional attention is needed when running barefoot to avoid stepping on objects that could potentially cause harm to the foot. Significant increases in participant’s heart rate were also found in the barefoot condition but not in the shod condition. No significant differences found in participants’ speed in the barefoot or shod condition, nor were there any in the target or no target condition. Together, these findings suggest that individuals working memory increases after at least sixteen minutes of barefoot running if they have to look at the ground to avoid objects that may cause harm to their feet. Barefoot running may help individuals of all ages; from delaying the onset of cognitive deterioration in the elderly, obesity prevention for individuals of all ages, to providing a boost in cognitive performance for children who are behind their peers in school.
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Brake, Derrick John. "The Deep Body Core Temperatures, Physical Fatigue and Fluid Status of Thermally Stressed Workers and the Development of Thermal Work Limit as an Index of Heat Stress". Curtin University of Technology, School of Public Health, 2002. http://espace.library.curtin.edu.au:80/R/?func=dbin-jump-full&object_id=12353.
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Objectives: To determine the physiological strain on industrial workers under thermal stress on extended shifts. To continuously measure deep body core temperatures, heart rates, fluid intake, changes in hydration state and physical fatigue in order to establish acceptable levels of physiological strain. To develop a rational heat stress index compatible with these limits. To design working-in-heat protocols for a self-paced workforce. Methods: A series of studies was conducted over 77 shifts on a group of approximately 50 male volunteers working in thermally stressful environments. Continuously- recorded deep body core temperatures, heart rates, fluid consumption, urinary specific gravity and physical fatigue were measured and recorded. A new field protocol was developed to assess physical fatigue over the working shift. An original methodology was developed to allow any heat stress index to be assessed on a comparative basis with any other index. A review of the commonly used occupational heat stress indices was conducted. A new rational heat stress index was developed, based on existing biophysical relationships and recommended physiological strain limits of deep body core temperature and sweat rate. New protocols designed for self-paced work incorporating the significant risk factors for heat illness were developed and implemented in a workforce of approximately 2000 workers exposed to heat stress. The previous protocols used a shortened shift as the primary intervention to protect worker health. The subsequent protocols removed the shortened shift and replaced this with a range of other interventions. Deep body core temperature, heart rate, fluid consumption, hydration state and fatigue were measured before and after the changes in protocols.Results: Comparisons of heat stress indices confirmed the wide divergence in guidance provided by many of the commonly-used indices in terms of acceptable working environments. It also highlighted a number of serious shortcomings in the most widely-used indices, especially WBGT and ISO7933. A new, rational heat stress index called Thermal Work Limit (TWL) was developed. This included development of a computer model incorporating key thermal physiological parameters (deep body core temperature, mean skin temperature, sweat rate, skin wettedness). There was no increase in heat stress (as indicated by average workplace environmental conditions), deep body core temperature, mean heart rate, or changes in hydration status after the changes in protocols. Average environmental conditions were severe (WBGT 30.9° C, sd 2.0° C, range 25.7-35.2° C). Environmental conditions in the study were much hotter than those considered acceptable under standards such as the ACGIH. The results showed that miners regularly exceeded those limits allowable under most current indices in terms of maximum deep body core temperature (avg 38.3° C, std dev 0.4° C), maximum temperature rise (1.4° C, 0.4° C) and maximum heat storage (431 kJ, 163 kJ), without reporting any symptoms of heat illness. A significant component of the observed elevated core temperatures was due to the normal circadian rhythm, which was measured at 0.9° C (std dev 0.2° C). Evidence was found that workers "self-pace" when under thermal stress. Fluid intake averaged 0.8 l/h during exposure (sd 0.3 l/h, range 0.3-1.5 1/h). Average urinary specific gravity at start-, mid- and end of shift was 1.0251, 1.0248 and 1.0254 respectively; the differences between start and mid-shift, mid and end-shift, and start and end-shift were not significant.
However, a majority of workers were coming to work in a moderately hypohydrated state (urinary specific gravity avg 1.024, std dev 0.0059). Involuntary dehydration was not found to occur in the study group. This is in contrast to several other studies and some of the leading heat stress standards, which are based on the premise that workers are unable to maintain their hydration status when working in the heat, even when their fluid consumption is equal to their sweat rate. Continuous heart rates measured over a shift (avg 103 bpm, 14% of shifts exceeding avg 110 bpm, 5% exceeding avg 120 bpm) were in excess of those allowable under most current indices On average, workers experienced a peak 10- minute heart rate of 140 bpm and a peak 30-minute heart rate of 130 bpm during their shifts. There was a significant increase in fatigue in the first half of the working shift (P=0.001), with workers on average showing a significant recovery in the second half of their shift (p=0.04). Conclusions: Current heat stress indices provide little common agreement as to acceptable levels of thermal strain or stress for workers, at equivalent levels of environmental stress. IS07933 is seriously flawed and the ACGIH WBGT guidelines are too conservative for acclimatised workers and are unlikely to become widely adopted by industries with well-acclimatised workers. Many of the existing indices show internal inconsistencies.
Most of the physiological heat strain limits used in existing rational heat stress indices (in terms of deep body core temperature and heart rate) are conservative for self-paced, acclimatise d, non-dehydrating male workers. Involuntary dehydration is not unavoidable when acclimatised workers are exposed to thermal stress. Heat stress standards should not limit heat exposure durations for self- paced workers who have access to water on the basis of an unavoidable body water loss. Physical fatigue does occur in workers under heat stress on extended shifts; however, most workers show a significant increase in fatigue in the first half of their shift; whereas data indicates self-paced workers undergo significant recovery in terms of fatigue in the second half of the shift. As the heat exposures in this study cover a wide range of temperatures, humidity levels, wind speeds, body morphology and VO2max, these conclusions are applicable to most thermally stressful settings involving well-informed, well-acclimatised and self-paced male workers. The major category of work type not covered by this study is that of workers in fully-encapsulated (vapour-barrier) protective clothing. In addition, this study examined acute effects of heat stress and strain, not effects that might only be manifest with chronic exposure to heat.
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Nyepetsi, Naledi Gape. "Effects of dietary Garcinia kola supplementation and oxidative stress in isolated perfused rat hearts". Thesis, Cape Peninsula University of Technology, 2014. http://hdl.handle.net/20.500.11838/1458.
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Thesis submitted in fulfilment of the requirements for the degree of
Master of Technology: Biomedical Technology
In the Faculty of Health and Wellness Sciences
At the Cape Peninsula University of Technology
Supervisors: Prof. Adriaan J Esterhuyse
Dr Dirk J Bester
Bellville
January 2014Background: Oxidative stress and chronic inflammation contributes significantly to the pathogenesis of several ischaemic heart diseases, including atherosclerotic plaque rupture and myocardial infarction. It is widely demonstrated that ischaemia, followed by reperfusion, results in alterations of the mitochondrial and endothelial function through uncontrolled cascades of events characterized by free radical release and inflammation. Recent experimental evidence shows that modulation of inflammatory and antioxidant signaling mediators may determine the host outcome following myocardial ischaemia-reperfusion injury. Investigations from the past decade indicate that food supplements may play an important role in the prevention and management of chronic inflammatory diseases. Garcinia kola seeds are flavonoid rich nut from a tropical flowering, non-timber plant of the Guttiferae family. This plant is highly valued in several African cultures for its use in herbal medicine. Recently, the majority of experimental research has linked phytochemicals found in Garcinia kola nut, to its proposed beneficial effects in treatment and management of oxidative stress related-chronic diseases. Research performed in our laboratory demonstrated that kolaviron, a prominent Garcinia kola flavonoid extract, reduces myocardial apoptosis during ischaemia-reperfusion injury. Therefore, the aim of our current study was to determine the effects of Garcinia kola supplementation on cardiac inflammatory and antioxidant signaling pathways during ischaemia-reperfusion using a Wistar rat heart model. Materials and Methods: Male wistar rats were randomly divided into two groups: a control group receiving 2ml/kg corn oil and the experimental group receiving 100mg/kg Garcinia kola dissolved in corn oil, daily for 4 weeks. After the feeding period, blood samples were collected and lymphocytic DNA damage was analyzed using the alkaline comet assay. Furthermore, rat hearts were isolated and perfused with Krebs-Henseleit buffer on a working heart perfusion apparatus to measure myocardial functional parameters. Myocardial functional recovery was measured after 15 minutes global ischaemia followed by 25 minutes reperfusion. Hearts were freeze clamped at three different time points for myocardial cytokine concentration determinations using multiplex electrochemilunescent immunoassay. Nuclear factor kappa beta (NF- kβ), p38 mitogen activated protein kinases (p38 MAPK), protein kinase B/Akt (PKB/Akt), nitro-tyrosine, inducible nitric oxide (iNOS), cyclooxygenase-2 (COX-2), poly (adenosine-di-phosphate) ribose polymerase-1 (PARP-1) and caspase-3 expression and their phosphorylated forms (where applicable) were analyzed using the Western blot technique. Results: Dietary Garcinia kola supplementation significantly improved functional recovery when compared to the control group as reflected by the improved aortic output recovery (68.47 ± 6.16% versus 44.96 ± 7.00%; p<0.05). Our biochemical results supports the hypothesis that, dietary Garcinia kola supplementation modulates different cardiac proteins in terms of expression and activation at different time points when compared to the control group. We show that, before induction of ischaemia, Garcinia kola supplementation attenuates expression of inflammatory mediators and pro-apoptotic proteins when compared to the control group. The improved functional recovery was associated with a prompt inflammatory response, activation of PKB/Akt and attenuation of protein nitrosylation after 10 minutes of reperfusion. Modulation of NF-kβ and the p38 MAPK family proteins expression could have also played a significant role in myocardial functional recovery. Conclusion: We have shown that a 4 week period of dietary Garcinia kola supplementation at 100mg/kg daily improves cardiac functional recovery following ischaemia-reperfusion injury. We propose that dietary Garcinia kola supplementation protects cardiac myocytes from ischaemia-reperfusion induced oxidative stress through the induction of a prompt inflammatory response and controlled expression and/or activation of the, NF-kβ, PKB/Akt and p38 MAPK protein signaling pathways PARP-1 and caspase. Finally, we demonstrated that dietary Garcinia kola supplementation did not induce rat lymphocytic DNA damage when compared to the control group.