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Tesis sobre el tema "DsRNase"

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Publicado: 11 de marzo de 2023

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1

Souza, Sandra Maria de. "Avaliação do silenciamento gênico em plantas utilizando estratégias baseadas em dsRNAs." reponame:Biblioteca Digital de Teses e Dissertações da UFRGS, 2006. http://hdl.handle.net/10183/165640.

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O silenciamento gênico tem sido utilizado extensivamente para facilitar a investigação de eventos da biologia vegetal. Ele pode ser induzido de diferentes modos, sendo que o passo chave para sua ocorrência é a presença de RNA fita dupla (dsRNA). A fim de avaliar um método rápido de obtenção de silenciamento para análise funcional em larga escala, foi inoculado dsRNA ou siRNA diretamente em folhas de plantas de arroz e de Nicotiana benthamiana. Os dsRNAs de seqüências do gene pds e do gene codificante da ferritina foram obtidos através da síntese in vivo e in vitro e o siRNA de PDS de arroz, de
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2

Cole, Thomas Edwin. "Molecular studies of virus-like dsRNAs in a diseased isolate of Ophiostoma novo-ulmi." Thesis, Imperial College London, 1999. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.327031.

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3

Vyas, Meenal, Amir Raza, Muhammad Yousaf Ali, et al. "Knock down of Whitefly Gut Gene Expression and Mortality by Orally Delivered Gut Gene-Specific dsRNAs." PUBLIC LIBRARY SCIENCE, 2017. http://hdl.handle.net/10150/622632.

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Control of the whitefly Bemisia tabaci (Genn.) agricultural pest and plant virus vector relies on the use of chemical insecticides. RNA-interference (RNAi) is a homology-dependent innate immune response in eukaryotes, including insects, which results in degradation of the corresponding transcript following its recognition by a double-stranded RNA (dsRNA) that shares 100% sequence homology. In this study, six whitefly `gut' genes were selected from an in silico-annotated transcriptome library constructed from the whitefly alimentary canal or 'gut' of the B biotype of B. tabaci, and tested for k
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4

Reddy, Vidita. "Role of dsRNA-induced DRAK1 in Apoptosis." University of Toledo / OhioLINK, 2018. http://rave.ohiolink.edu/etdc/view?acc_num=toledo1513349817056948.

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5

Lu, Lenette L. "dsRNA Signaling in Innate Immunity and Viral Inhibition." Case Western Reserve University School of Graduate Studies / OhioLINK, 2009. http://rave.ohiolink.edu/etdc/view?acc_num=case1220030971.

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6

Muccioli, Maria. "Characterizing dsRNA-induced inflammation in ovarian cancer cells." Ohio University / OhioLINK, 2014. http://rave.ohiolink.edu/etdc/view?acc_num=ohiou1405707670.

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7

Kilic, Ozlem III. "Effect of dsRNA-containing and dsRNA-free hypovirulent isolates of Fusarium oxysporum on severity of Fusarium seedling disease of Essex soybean." Thesis, Virginia Tech, 1997. http://hdl.handle.net/10919/36965.

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Sixty-six isolates of <I>F. oxysporum</I> and <I>F. solani</I> were recovered from healthy and necrotic Essex soybean seedlings grown in naturally infested soil. These were tested for pathogenicity at 20 C and -0.01 MPa water potential in artificially infested, autoclaved field soil. Highly pathogenic, moderately pathogenic, and hypovirulent isolates of both species were identified. Fifty-seven <I>F. oxysporum</I> and nine <I>F. solani</I> isolates were tested for the presence of dsRNA. The presence of dsRNA was not associated with hypovirulence in <I>F. oxysporum</I> since some hypovirulent
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8

Rodrigues, Paula. "Produção e caracterização de um antissoro policlonal para detecção de ds-RNA." Bachelor's thesis, UTAD, 1998. http://hdl.handle.net/10198/997.

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Os fitopatologistas têm feito um uso cada vez maior dos métodos serológicos na detecção e caracterização de fitopatogénios, por se tratar de técnicas rápidas, práticas e de elevada sensibilidade, que se podem adaptar às necessidades. De entre estes testes, as várias adaptações do ELISA (enzyme-linked immunosorbent assay) são, actualmente, os métodos mais divulgados, uma vez que permitem testar um elevado número de amostras num curto espaço de tempo e a preço moderado. A maioria dos vírus fitopatogénicos tem genoma de ss-RNA (ácido ribonucleico monocatenário) que, durante o processo replicativo
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9

Potgieter, Abraham Christiaan. "Cloning viral dsRNA genomes : analysis and application / A.C. Potgieter." Thesis, North-West University, 2004. http://hdl.handle.net/10394/334.

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Double-stranded RNA viruses occur in a large number of hosts in nature ranging from bacteria to mammals. Molecular studies of the double-stranded RNA viruses have greatly enhanced man's understanding of this large group of viruses as far as structure and function of their genes and epidemiology is concerned. However, one of the major prerequisites of obtaining this information is the ability to clone the genomes of these viruses for nucleotide sequencing and recombinant protein expression studies. In the dsRNA field, cloning viral genomes has historically been difficult and time consuming and
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10

Robinson, Helen Lynne. "Characterization of double-stranded RNA (dsRNA) from Rhizoctonia solani." Thesis, University of Edinburgh, 1999. http://webex.lib.ed.ac.uk/abstracts/robins01.pdf.

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11

Ho, Wing-tak, and 何永德. "Glycyrrhizic acid potentiates dsRNA-induced nitric oxide generation inalveolar macrophages." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2004. http://hub.hku.hk/bib/B31971799.

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12

Stricker, Ruth Lydia Olga [Verfasser], S. E. [Akademischer Betreuer] Behrens, E. [Akademischer Betreuer] Mundt, and E. [Akademischer Betreuer] Vahlenkamp. "Influence of cellular dsRNA binding proteins in the replication process of a dsRNA virus / Ruth Lydia Olga Stricker. Betreuer: S.-E. Behrens ; E. Mundt ; E. Vahlenkamp." Halle, Saale : Universitäts- und Landesbibliothek Sachsen-Anhalt, 2012. http://d-nb.info/1025352467/34.

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13

Ho, Wing-tak. "Glycyrrhizic acid potentiates dsRNA-induced nitric oxide generation in alveolar macrophages." Click to view the E-thesis via HKUTO, 2004. http://sunzi.lib.hku.hk/hkuto/record/B31971799.

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14

Beyleveld, Mia. "Interaction of nonstructural protein NS3 of African horsesickness virus with viral and cellular proteins." Diss., Pretoria : [s.n.], 2007. http://upetd.up.ac.za/thesis/available/etd-12132007-115112.

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15

Brown, Joanne Louise. "The role of the dsRNA dependent protein kinase (PKR) in cell signalling." Thesis, St George's, University of London, 1999. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.391775.

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16

Figueirêdo, Girlene Soares de. "Potencial Antagônico de Trichoderma spp. associados a dsRNA contra Colletotrichum guaranicola (Albuq.)." Universidade Federal do Amazonas, 2010. http://tede.ufam.edu.br/handle/tede/4491.

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17

Moura, Vanessa Santos [UNESP]. "Caracterização bioquímica e funcional de toxina killer produzida por Saccharomyces cerevisiae." Universidade Estadual Paulista (UNESP), 2017. http://hdl.handle.net/11449/151466.

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18

Noland, Jeffrey Edward. "RISK PARAMETERS AND ASSESSMENT OF DIETARY dsRNA EXPOSURE IN FOLSOMIA CANDIDA." UKnowledge, 2017. http://uknowledge.uky.edu/entomology_etds/37.

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Assessing the risk of transgenic crop products is essential when determining the safety of a crop for deregulation and commercialization. The Organization of Economic and Cooperative Development (OECD), International Standards Organization (ISO), and governmental regulatory agencies require a battery of tests to demonstrate the safety of a GM product against several surrogate species of organisms that perform various ecosystem services. Assays are performed using toxicology methods established for pesticides. These methods have been applied to testing the safety, specificity and fate of Bacill
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19

Ostertag, Derek Glenn. "Novel dsRNA-dependent activation of a cellular antiviral response to vesicular stomatitis virus /." Diss., Connect to a 24 p. preview or request complete full text in PDF format. Access restricted to UC campuses, 2005. http://wwwlib.umi.com/cr/ucsd/fullcit?p3167840.

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20

DAINO, GIANLUCA. "Characterization of Ebola virus VP35-dsRNA binding for drug development against Ebola virus disease." Doctoral thesis, Università degli Studi di Cagliari, 2017. http://hdl.handle.net/11584/248693.

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The Ebola virus (EBOV) VP35 protein plays an important role in the inhibition of the initial innate immune responses to EBOV infection leading to Ebola virus disease development. In fact, VP35 interaction with the RIG-I like receptors (RLR) cascade components inhibits the interferon (IFN) production, impeding proper host immune response. Hence, it has been shown that VP35 is a validate drug target. Full-length His-tagged recombinant VP35 (rVP35) has been previously expressed in prokaryotic system and used to validate a biochemical pull-down assay for the screening of small molecules targeted t
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21

Schwartz, Thomas. "Structural basis for left handed Z-DNA binding by human dsRNA specific adenosine deaminase ADAR1." [S.l.] : [s.n.], 1999. http://www.diss.fu-berlin.de/2000/34/index.html.

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22

Elco, Christopher. "Regulation of dsRNA-induced transcription by NFêB and IRF-3 through TLR3 and RIG-1." Connect to text online, 2007. http://rave.ohiolink.edu/etdc/view?acc%5Fnum=case1182005526.

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23

Lowe, Katie. "An investigation into the induction of tumour cell apoptosis by dsRNA : a pro-inflammatory event?" Thesis, St George's, University of London, 2012. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.568723.

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Dendritic cells (DCs) exhibit the capacity to recognise and phagocytose dying cells and invading pathogens and to present antigens from this internalised material on their surface. The recognition of these antigens by T cells can induce specific cytotoxic responses against other cells expressing the same antigen. These characteristics suggest the potential for DCs to be used a Cancer vaccine, due to their ability to stimulate an immune response against tumour cells. To ensure that cytotoxicity, rather than tolerance to the presented antigens is induced, co- stimulatory molecule expression on a
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24

Özkan, Selin. "Investigations of Aspergillus fumigatus RNA silencing mechanisms and pathogenicity in the presence of dsRNA mycoviruses." Thesis, Imperial College London, 2014. http://hdl.handle.net/10044/1/44122.

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Mycoviruses are a specific group of viruses that naturally infect and replicate in fungi. Aspergillus fumigatus, an opportunistic pathogen causing fungal lung diseases in humans and animals, is recently shown to harbour at least three different types of mycoviruses. RNA silencing mechanisms exist in fungi against mycoviruses and it is also known that A. fumigatus encodes all the proteins involved in RNA silencing, including Dicer and Argonaute homologues. Therefore, it is anticipated that small interfering RNAs (siRNAs) are generated and silencing of viral dsRNAs occurs as seen with other myco
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25

Elco, Christopher. "REGULATION OF dsRNA-INDUCED TRANSCRIPTION BY NFêB AND IRF-3 THROUGH TLR3 AND RIG-I." Case Western Reserve University School of Graduate Studies / OhioLINK, 2007. http://rave.ohiolink.edu/etdc/view?acc_num=case1182005526.

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26

Obadia, Benjamin. "Antiviral RNAi is initiated by dsRNA internalization into midgut cells in the insect model Drosophila." Paris 6, 2013. http://www.theses.fr/2013PA066227.

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Les insectes se sont adaptés à une variété admirable d'environnements où ils rencontrent divers microorganismes. Par conséquent, au cours de leur évolution, leurs mécanismes de défense ont été modelés pour générer un systme immunitaire flexible, leur permettant de survivre aux infections, mais favorisant, par ailleurs, une meilleure diffusion des microbes aux autres animaux. Historiquement, et de faon récurrente, les maladies transmises par les insectes ont constitué une grave menace pour les humains et ont concentré les efforts de recherche sur les interactions insecte-bactérie pluôt que s
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27

Cramer, Tamlyn Jill. "Monitoring the African horsesickness virus life cycle by real-time RT-PCR of viral dsRNA." Diss., University of Pretoria, 2010. http://hdl.handle.net/2263/29034.

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African horsesickness (AHS), caused by African horsesickness virus (AHSV), is an infectious, non-contagious, insect-borne viral disease that affects members of the Equidae family. AHSV is a non-enveloped virus, consisting of 10 segments of double stranded RNA (dsRNA) encoding seven structural and four non-structural proteins. Infection of mammalian cell cultures with AHSV leads to severe cellular pathogenesis effects (CPE), whereas insect cells show no noticeable CPE. Differences are also apparent between different serotypes of AHSV with regards to viral production, viral release, membrane per
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28

Chukwudi, Chinwe Uzoma. "dsRNA as a target for tetracyclines and berberine, and a stress response regulator in Escherichia coli." Thesis, Royal Veterinary College (University of London), 2012. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.572453.

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29

Ghazal, Ghada. "Biochemical and genetic analysis of RNA processing and decay." Thèse, Université de Sherbrooke, 2009. http://savoirs.usherbrooke.ca/handle/11143/4287.

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Gene expression is the conduit by which genetic information is connected into cellular phenotypes. Recently, it was shown that gene expression in mammalian cells is governed, at least in part, by the expression of short double stranded RNA (dsRNA). This mode of gene regulation is influenced by a large group of dsRNA binding proteins that could either stabilize or trigger the degradation of dsRNA. Indeed, double stranded RNA (dsRNA) specific ribonucleases (RNases) play an important role in regulating gene expression. In most eukaryotes, members of the dsRNA specific RNase III family trigger RNA
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30

Abraham, Ninan. "Consequences of loss of the murine dsRNA-dependent protein kinase, PKR, by natural mutation or genetic ablation." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1998. http://www.collectionscanada.ca/obj/s4/f2/dsk2/ftp03/NQ36761.pdf.

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31

Blanc, Antony. "Capture of eukaryotic mRNA cap structures by the coat protein of the yeast L-A dsRNA virus." Thesis, McGill University, 1994. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=41540.

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The eukaryotic mRNA 5$ sp prime$ cap structure m$ sp7$GpppX (where X is any nucleotide) is of crucial importance in translation initiation and protects messenger RNAs (mRNAs) against exonucleolytic degradation. L-A and L-BC are double-stranded RNA viruses which are persistently maintained in the cytoplasm of many Saccharomyces cerevisiae strains. Unexpectedly, their coat proteins exhibited a strong cap-binding activity. Unlike any other cap-binding protein, the coat protein (gag) of the L-A virus was shown to attach covalently to the cap structure of mRNAs, resulting in the cleavage of the cap
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32

Sehki, Hayat. "Rôle d’un suppresseur endogène de RNAi dans le développement de la plante et ses interactions avec les pathogènes." Thesis, université Paris-Saclay, 2020. http://www.theses.fr/2020UPASB034.

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Le Post-Transcriptional Gene Silencing (PTGS) est un mécanisme dirigé contre les acides nucléiques invasifs endogènes (transposons) et exogènes (pathogènes, transgènes). Dans le cas des virus, le PTGS peut s’attaquer aux ARNs double-brin (dsRNAs) intermédiaires de la réplication virale et aux ARNs simple-brin viraux, mais il est souvent inhibé par des protéines virales appelées Viral Suppressor of RNAi (VSR). Chez la plante modèle Arabidopsis thaliana, une enzyme appelée RNase THREE-LIKE 1 (RTL1) est induite en réponse à l'infection virale et détruit les dsRNAs de manière non sélective. Cette
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33

DeWitte-Orr, Stephanie. "A study of innate antiviral mechanisms using fish cell lines." Thesis, University of Waterloo, 2006. http://hdl.handle.net/10012/1272.

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Understanding basic antiviral mechanisms in vertebrates is essential for developing methods to enhance antiviral responses and promote human and animal health. In fish these antiviral mechanisms are poorly understood, but are important to understand because of the devastating impact of viral diseases on aquaculture. Therefore, the antiviral responses of a rainbow trout macrophage-like cell line, RTS11, and two non-immune cell lines, the rainbow trout fibroblast RTG-2 and Chinook salmon embryo CHSE-214 were studied. Three antiviral responses were first characterized using the viral mim
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34

Rocha, Guilherme Zweig 1983. "A atuação da proteína quinase dependente de dsRNA (PKR) no desenvolvimento de tumor de cólon em camundongos obesos." [s.n.], 2014. http://repositorio.unicamp.br/jspui/handle/REPOSIP/312750.

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Orientador: José Barreto Campello Carvalheira<br>Tese (doutorado) - Universidade Estadual de Campinas, Faculdade de Ciências Médicas<br>Made available in DSpace on 2018-08-25T19:07:24Z (GMT). No. of bitstreams: 1 Rocha_GuilhermeZweig_D.pdf: 7543896 bytes, checksum: 5459a8edf8e3ca3315e980f52bbbb876 (MD5) Previous issue date: 2014<br>Resumo: Embora a obesidade seja reconhecida como importante causa de diabetes e doença cardiovascular, a associação entre obesidade e diferentes tipos de câncer tem recebido muito menos atenção. A associação entre obesidade e o desenvolvimento de câncer de cólon r
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Lima, Swiany Silveira. "Incidência e transmissão de dsRNA em Pseudocercospora griseola, agente causal da mancha-angular do feijoeiro comum (Phaseolus vulgaris)." Universidade Federal de Viçosa, 2008. http://locus.ufv.br/handle/123456789/5300.

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Darissa, Omar [Verfasser]. "Molecular characterization of a novel segmented dsRNA mycovirus and its association with hypovirulence of Fusarium graminearum / Omar Darissa." Hamburg : Staats- und Universitätsbibliothek Hamburg, 2011. http://d-nb.info/1010759787/34.

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Carvalho, Eudislaine Fonseca de. "Resposta antiviral em células LL5 de Lutzomyia longipalpiscomparativo entre infecção por vírus da Estomatite Vesicular (VSV) e dsRNA." reponame:Repositório Institucional da FIOCRUZ, 2013. https://www.arca.fiocruz.br/handle/icict/13940.

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Made available in DSpace on 2016-04-20T12:39:28Z (GMT). No. of bitstreams: 2 eudislaine_carvalho_ioc_mest_2013.pdf: 1777151 bytes, checksum: 5c17debede158ac9bc7692a3a408b4ba (MD5) license.txt: 1748 bytes, checksum: 8a4605be74aa9ea9d79846c1fba20a33 (MD5) Previous issue date: 2013<br>Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Rio de Janeiro, RJ, Brasil<br>As doenças transmitidas por insetos vetores são de grande importância para saúde pública. No Brasil, as principais doenças compreendem a malária, doença de Chagas, leishmaniose, dengue e febre amarela. O inseto vetor flebotomíneo é o prin
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38

Belhouchet, Mourad. "Analysis of an anti-silencing mechanism involved in immune evasion by vector-borne dsRNA animal viruses of family Reoviridae." Thesis, University of Oxford, 2013. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.711672.

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39

Thornley, Thomas B. "IFN-α/β Induction by dsRNA and Toll-Like Receptors Shortens Allograft Survival Induced by Costimulation Blockade: A Dissertation". eScholarship@UMMS, 2006. https://escholarship.umassmed.edu/gsbs_diss/254.

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Costimulation blockade protocols are promising alternatives to the use of chronic immunosuppression for promoting long-term allograft survival. However, the efficacy of costimulation blockade-based protocols is decreased by environmental insults such as viral infections. For example, lymphocytic choriomeningitis virus (LCMV) infection at the time of costimulation blockade treatment abrogates skin allograft survival in mice. In this dissertation, we test the hypothesis that viruses shorten allograft survival by activating the innate immune system through pattern-recognition receptors (PRRs), su
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40

Dickerman, Benjamin K. "THE PHYSIOLOGICAL FUNCTION OF THE dsRNA-BINDING PROTEIN PACT/RAX, PROTEIN ACTIVATOR OF PKR AND ITS ROLE IN MOUSE DEVELOPMENT." Case Western Reserve University School of Graduate Studies / OhioLINK, 2012. http://rave.ohiolink.edu/etdc/view?acc_num=case1335901974.

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41

Nathania, Lilian. "Biochemical Analysis of Thermotoga maritima Ribonuclease III and its Ribosomal RNA Substrates." Diss., Temple University Libraries, 2011. http://cdm16002.contentdm.oclc.org/cdm/ref/collection/p245801coll10/id/140013.

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Chemistry<br>Ph.D.<br>The site-specific cleavage of double-stranded (ds) RNA is a conserved early step in bacterial ribosomal RNA (rRNA) maturation that is carried out by ribonuclease III. Studies on the RNase III mechanism of dsRNA cleavage have focused mainly on the enzymes from mesophiles such as Escherichia coli. In contrast, little is known of the RNA processing pathways and the functions of associated ribonucleases in the hyperthermophiles. Therefore, structural and biochemical studies of proteins from hyperthermophilic bacteria are providing essential insight on the sources of biomolecu
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42

Elbahesh, Husni M. "Study of Innate Immune Response Components in West Nile Virus Infected Cells." Digital Archive @ GSU, 2011. http://digitalarchive.gsu.edu/biology_diss/94.

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Two cellular innate responses, the dsRNA protein kinase (PKR) pathway and the 2'-5' oligoadenylate synthetase (OAS)/RNase L pathway, are activated by dsRNAs produced by viruses and reduce translation of host and viral mRNAs. PKR activation results in eIF2a phosphorylation. As a consequence of eIF2a phosphorylation, stress granules (SGs) are formed by the aggregation of stalled SG proteins with pre-initiation complexes and mRNA. West Nile virus (WNV) infections do not induce eIF2a phosphorylation despite upregulation of PKR mRNA and protein suggesting an active suppression of PKR activation. As
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43

Bento, Flavia de Moura Manoel. "Silenciamento gênico por interferência de RNA (RNAi) em traça-do-tomateiro, Tuta absoluta (Meyrick), utilizando bactérias expressando dupla fita de RNA (dsRNA)." Universidade de São Paulo, 2017. http://www.teses.usp.br/teses/disponiveis/11/11137/tde-06042018-144427/.

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O uso da técnica de RNAi vem sendo avaliada em diversos insetos-pragas pois, é uma estratégia inovadora que pode ser integrada no manejo de importantes pragas agrícolas. Os insetos da Ordem Lepidoptera são reconhecidos por apresentarem recalcitrância à técnica de silenciamento utilizando dsRNA. Assim, ajustes devem ser feitos aos métodos de entrega de dsRNA para que haja estabilidade da molécula até atingir o mRNA alvo de silenciamento no inseto. O silenciamento gênico por RNAi possui potencial de uso para o controle da \"traça-do-tomateiro\" Tuta absoluta (Meyrick, 1917) (Lepidoptera: Gelechi
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44

Garcia, Rayssa Almeida. "Validação da estabilidade de estruturas de dsRNA para uso no silenciamento gênico de insetos-praga : avaliação na planta e no inseto alvo." reponame:Repositório Institucional da UnB, 2015. http://dx.doi.org/10.26512/2015.02.D.18462.

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Dissertação (mestrado)—Universidade de Brasília, Programa de Pós-Graduação em Biologia Molecular, 2015.<br>Texto parcialmente liberado pelo autor. Conteúdo restrito: capítulos I, II e III.<br>Submitted by Ana Cristina Barbosa da Silva (annabds@hotmail.com) on 2015-06-29T16:49:59Z No. of bitstreams: 1 2015_RayssaAlmeidaGarcia_Parcial.pdf: 404317 bytes, checksum: 9c6cd5a3cdd519dad13504c7fdb4b4e4 (MD5)<br>Approved for entry into archive by Raquel Viana(raquelviana@bce.unb.br) on 2015-07-20T12:06:44Z (GMT) No. of bitstreams: 1 2015_RayssaAlmeidaGarcia_Parcial.pdf: 404317 bytes, checksum: 9c6cd5
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Almeida, João Paulo Pereira de. "O transcritoma antisense primário de Halobacterium salinarum NRC-1." Universidade de São Paulo, 2018. http://www.teses.usp.br/teses/disponiveis/17/17131/tde-15012019-101127/.

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Em procariotos, RNAs antisense (asRNAs) constituem a classe de RNAs não codificantes (ncRNAs) mais numerosa detectada por métodos de avaliação de transcritoma em larga escala. Apesar da grande abundância, pouco se sabe sobre mecanismos regulatórios e aspectos da conservação evolutiva dessas moléculas, principalmente em arquéias, onde o mecanismo de degradação de RNAs dupla fita (dsRNAs) é um fenômeno pouco conhecido. No presente estudo, utilizando dados de dRNA-seq, identificamos 1626 inícios de transcrição primários antisense (aTSSs) no genoma de Halobacterium salinarum NRC-1, importante orga
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46

Shi, Zhongjie. "Biochemical properties and substrate reactivities of Aquifex Aeolicus Ribonuclease III." Diss., Temple University Libraries, 2012. http://cdm16002.contentdm.oclc.org/cdm/ref/collection/p245801coll10/id/213666.

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Chemistry<br>Ph.D.<br>Ribonuclease III is a highly-conserved bacterial enzyme that cleaves double-stranded (ds) RNA structures, and participates in diverse RNA maturation and decay pathways. Essential insight on the RNase III mechanism of dsRNA cleavage has been provided by crystallographic studies of the enzyme from the hyperthermophilic bacterium, Aquifex aeolicus. However, those crystals involved complexes containing either cleaved RNA, or a mutant RNase III that is catalytically inactive. In addition, neither the biochemical properties of A. aeolicus (Aa)-RNase III, nor the reactivity epit
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47

Saunders, Caroline Ginny. "A study of orchid mycorrhizal fungi : an examination of the influence of dsRNA elements on symbiosis and the application of molecular methods for fungal identification." Thesis, University of Hull, 1997. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.389288.

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羽者家, 宝. "植物内在性dsRNAによる全身性の免疫系活性化効果とその応用". Kyoto University, 2019. http://hdl.handle.net/2433/245330.

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49

Xie, Bingning. "Long non-coding RNA-based mechanisms for the inhibition of cell growth and development by 5 - Fluorouracil." Thesis, Rennes 1, 2016. http://www.theses.fr/2016REN1B046/document.

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Les ARNm codent pour les protéines, tandis qu'un grand nombre d'ARNs nommés longues ARNs non codants (ARNlnc) ne sont pas traduites en protéines. Les deux types d’ARNs existent en isoforms qui se distinguent à cause de l’épissage alternatif. Certains des ARNlnc jouent des rôles importants dans la croissance et différentiation cellulaire. Cependant, leurs fonctions dans la cytotoxicité de la chimiothérapie anti-cancéreuse médicamenteuse utilisant le 5-fluorouracile (5-FU) sont encore inconnues. Pendant mes travaux j'ai trouvé que le traitement par le 5-FU cause l’accumulation des ARNlnc. Ce phé
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50

Hahn, Sabine. "Virologische Untersuchungen an Stieleichen (Quercus robur L.) zum verursachenden Pathogen der pfropfübertragbaren chlorotischen Ringflecken." Doctoral thesis, Humboldt-Universität zu Berlin, Landwirtschaftlich-Gärtnerische Fakultät, 2006. http://dx.doi.org/10.18452/15457.

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Regelmäßige Bonituren haben gezeigt, dass virusverdächtige Symptome an Stieleichen, die zu etwa 90 % als chlorotische Ringflecken auftreten, im nord- und mitteldeutschen Raum weit verbreitet sind. In der vorliegenden Arbeit sollte der Erreger dieser Symptome isoliert und näher charakterisiert werden. Aus zwei Blattproben mit chlorotischen Ringflecken konnten stäbchenförmige Viruspartikeln mit einer Länge von ca. 450 nm isoliert und auf krautige Indikatoren übertragen werden. In einer RT-PCR mit Hüllprotein bzw. Transportprotein-sequenzspezifischen Primern wurden diese als Tobacco mosaic virus
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