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Degelman, Douglas y Amy J. Smith. "Perceived Gender of a Pastor's Name and Ratings of Vocational Success". Psychological Reports 96, n.º 2 (abril de 2005): 457–63. http://dx.doi.org/10.2466/pr0.96.2.457-463.
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Undergraduate students (16 men and 16 women) from a Christian university read a 1-page description of a pastor named either “Carl Anderson” or “Carol Anderson.” Students rated each named pastor on four items summed for a measure of vocational success. We predicted, based on role congruity, that students would rate a female-named pastor lower than a male-named pastor on the measure, but women's ratings of pastoral vocational success were significantly higher. Men's ratings did not differ significantly for the male- and female-named pastors. Power was low so further research is appropriate.
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Muse, J. Steven. "Faith, Hope, and the “Urge to Merge” in Pastoral Ministry: Some Countertransference-Related Distortions of Relationship between Male Pastors and their Female Parishioners". Journal of Pastoral Care 46, n.º 3 (septiembre de 1992): 299–308. http://dx.doi.org/10.1177/002234099204600309.
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Explicates the nature, extent, and potential of countertransference developing as male pastors serve as caregivers to female parishioners. Provides a list of “warning signs” which can alert the pastor to inappropriate stances and offers recommendations for assisting caregivers to develop intimate relationships without sexualizing them.
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Yoo, Jieun. "A Qualitative Study on the Experience of Military Life and Ministry of Korean Christian Female Military Pastors". Religions 12, n.º 3 (26 de febrero de 2021): 153. http://dx.doi.org/10.3390/rel12030153.
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The purpose of this study was to understand who female military pastors are in the Korean military and examine their military lives and ministry experiences through in-depth interviews and qualitative analysis. Six of the eight female military pastors currently working participated in this study. Seven major themes were identified: motivation to apply, role confusion and ambiguity, token women in the Korean military, perceived barriers or bias, equality experience, lack of network or mentor, and work and family balance. This study was helpful for obtaining a deeper understanding of female military pastors who exist as a minority in the Korean military. This study also provides basic information for the seminary education of future female military pastors and policies for female leaders working in the Korean military.
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Meyer-Wilmes, Hedwig. "Identity By Conflicts ? Female Pastors Between Caring and Career". Journal of Empirical Theology 11, n.º 2 (1998): 41–45. http://dx.doi.org/10.1163/157092598x00121.
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Sjö, Sofia. "The Gendering of Pastors in Contemporary Nordic Films: Norms, Conventions and Contemporary Views". Religion and Gender 5, n.º 1 (19 de febrero de 2015): 91–104. http://dx.doi.org/10.18352/rg.10084.
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The article examines how Lutheran pastors are gendered in six well-known Nordic films. Building on the theory of mediatisation of religion, the study argues for the need to look at how media shapes religion and gender for a thorough understanding of views on religion today. The film analyses show a connection between female pastors and less problematised forms of religion, but also traditional ways of undermining women in films. The films are argued to present a problematised religious view on sexuality, mostly connected to male pastors. Both aspects of gendering religion are tied to larger debates and discussions of religion and gender in the Nordic countries today. The article suggests that media have the potential to challenge traditional religious norms and to present their own norms, and highlights the need for further comparative studies.
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Alencar, Gedeon Freire. "Pastores Assembleianos na Universidade: A Polissemia Assembleiana da Terceira Geração Pastoral". REFLEXUS - Revista Semestral de Teologia e Ciências das Religiões 8, n.º 12 (13 de mayo de 2015): 289. http://dx.doi.org/10.20890/reflexus.v8i12.244.
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Resumo: Em termos quantitativos, a população universitária e a membresia das Assembleias de Deus são parecidas. Em 1991, os universitários eram 3.928.260 e os assembleianos 2.439.770. Em 2010, o número de universitários subiu para 12.679.010 e o de assembleianos para 12.314.410. Cresceu o numero de universitários e também o de assembleianos, inclusive de assembleianos universitários e de pastores. Quem são esses pastores assembleianos com nível superior e o que eles pensam? Foram enviados mais de mil emails para pessoas que integravam listagens de convenções, ministérios e igrejas, e também para amigos indicados por essas pessoas. Preenchidos e devolvidos, somaram 84 questionários. A primeira parte eram questões pessoais: residência, idade, sexo, estado civil, escolaridade, profissão e ministério, conversão. Além dessas questões, a pesquisa se dividiu em blocos: questões doutrinárias, institucionais, políticas e sociais. O caleidoscópio absolutamente multifacetado e plural mostra a cara dessa denominação que tem um nome único, Assembleias de Deus, mas essa pluralidade não está apenas no nome, mas também em sua natureza. Atualmente, são mais de 12 milhões de assembleianos (dados do Censo 2010), conquanto seja impossível quantificar o número de pastores/as. Desde a década de 1950, a Assembleia de Deus é a maior denominação pentecostal do país, embora diferentes entre si, distintas e, quase sempre, divergentes. Nasceram em 1911 já plurais, mas a terceira geração de pastores assembleianos leva isso ao extremo. Esse novo estamento assembleiano – pastores com curso universitário e/ou pós-graduação – é uma nova liderança: quais condutas, tendências doutrinárias e políticas é o que se pretende entender nesta pesquisa. Palavras-chave: Universitários. Pastores Assembleianos. Identidade. Bricolagem Religiosa. Assembleias de Deus. Abstract: In quantitative terms, university student population and the membership of the Assemblies of God are alike in Brazil. There were 3,928,260 university students in 1991 and 2,439,770 members in the Assemblies of God. In 2010, the number of students had risen to 12,679,010 students and to12,314,410 for members of the Assemblies of God. Both the number of university students and Assembly of God members have increased, including university students who are members or pastors from the Assemblies of God. Who are these university graduate Assembly of God pastors and what do they think? Over a thousand emails were sent to people from listings of conventions, ministries and churches, and also to friends indicated by those people; and 84 questionnaires were filled and returned. The first part of the questionnaire dealt with personal information questions: residence, age, sex, marital status, education, occupation, ministry, and conversion. Besides that, the research was divided into blocks: doctrinal, institutional, political and social issues. The multifaceted and plural kaleidoscope shows the face of this denomination that has a unique name, Assemblies of God, but this plurality isn’t only in its name, but also in its nature. There are currently more than 12 million members in the Assemblies of God (2010 Census), and it is impossible to quantify the number of ministers both male and female. Since the 1950s the Assemblies of God has accounted for the largest Pentecostal denomination in the country; and its associated churches are diverse, different, and often divergent. They were born plural in 1911, but the third generation of the Assembly pastors has taken it to the extreme. This new Assembly of God estate (ou “stratum”) makes up a new leadership. This research intends to understand the conduct, doctrinal and political trends of the current Assembly of God leadership. Keywords: University Students. Assembly of God Pastors. Identity. Religious Bricolage. Assemblies of God.
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Middleton, Revardale Lavant y Virginia A. Hinton. "A Preliminary Investigation of the Vocal Behaviors and Characteristics of Female Pastors". Journal of Voice 23, n.º 5 (septiembre de 2009): 594–602. http://dx.doi.org/10.1016/j.jvoice.2008.01.002.
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Rosendahl, Dan y Sirpa Rosendahl. "Role Stress. Experiences of Swedish Non-Lutheran Clergy". European Journal of Social Sciences 3, n.º 1 (10 de febrero de 2020): 108. http://dx.doi.org/10.26417/ejss.v3i1.p108-118.
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Background: About fifty percent of Swedish Non-Lutheran Clergy leave the vocation before retirement resulting in huge personal, financial, psychological, emotional, spiritual and social costs. The factors behind this substantial flood out has scarcely been researched. From the multifaceted problematic aspects of pastoral work, the aim of this study was to explore the clergy’s experiences of work stressors with the focus on Role-stress. Method: A qualitative approach with 19 open ended interviews was used and the interview material underwent qualitative content analysis. Results: Multiple external role-senders together with the individual pastor’s experienced, internal expectations and demands, generated different types of Clergy role-categories that surfaced during the analysis. These roles were accompanied by several role-stressors as apparent with the roles Servants of men and Servants of God and the presence of Vision Conflict. Further the pastor as the Church’s ultimately responsible person is plagued by Role-ambiguity and Role-confusion, and as the Proven trustworthy administrator struggling with Role-conflict. Family-work and Work-family conflicts, especially for female pastors, contributed to Work overload, this consequence also effecting the male colleagues during the generic attempts to meet as many of the Church members’ expectations as possible. The accumulated Work overload, together with a lowered level of Work Satisfaction, boosted the Turnover intentions. Conclusions: Mutual succinct information between employer and employee, active continuous communication and refined and updated organizational structure need to be coordinated in order to lower the level of experienced role stress and thus reduce the present substantial number of Clergy leaving the vocation prematurely.
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Lin, Yu-Fen, Chi-Sing Li, Beverly Irby y Genevieve Brown. "Exploring Taiwanese Female Pastors' Intimate Relationships: Using the Story of the Levite's Concubine". Counseling and Values 58, n.º 2 (octubre de 2013): 142–57. http://dx.doi.org/10.1002/j.2161-007x.2013.00030.x.
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Lin, Yu-Fen, Chi-Sing Li, Beverly J. Irby y Genevieve Brown. "A Feminist Group Counseling Model to Address Asian Female Pastors’ Self-Esteem Related Issues". Psychology 04, n.º 11 (2013): 902–11. http://dx.doi.org/10.4236/psych.2013.411130.
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Gaddini, Katie Christine. "‘Wife, Mommy, Pastor and Friend’: The Rise of Female Evangelical Microcelebrities". Religions 12, n.º 9 (13 de septiembre de 2021): 758. http://dx.doi.org/10.3390/rel12090758.
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The popularity of digital media has spurred what has been called a “crisis of authority”. How do female evangelical microcelebrities figure in this crisis? Many of these women belong to churches led by male pastors, have amassed a large following online, and are sought-after speakers and teachers. This paper analyses how gender, religious authority, and the digital sphere collide through the rise of female evangelical microcelebrities. Bringing together ethnographic data, textual analysis, and social media analysis of six prominent women, I emphasize the power of representation to impact religious practices and religious meaning. This article examines how evangelical women are performing and negotiating their legitimacy as the Internet and fluid geographical boundaries challenge local models of religious authority. Moving away from a binary perspective of “having” or “not having” authority, this paper considers the various spheres of authority that evangelical microcelebrities occupy, including normative womanhood, prosperity theology, and politics. Finally, by examining the social media content put forth by female evangelical microcelebrities, I interrogate the political stakes of evangelical women’s authority.
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Vargas, Ignacio Madera. "A FÊ DOS POBRES: DESAFIO Â NOVA EVANGELIZAÇÃO". Perspectiva Teológica 45, n.º 125 (24 de octubre de 2014): 107. http://dx.doi.org/10.20911/21768757v45n125p107/2013.
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A fé dos pobres possui uma lógica interna que é necessário aprofundar para identificar o que dita lógica pode oferecer aos processos de nova evangelização na Igreja e da missão continental proposta por Aparecida. No interior da confissão de fé, compreendida em seus níveis epistemológico e ético, caracteriza-se a fé dos pobres em suas dimensões de minoridade, resistência e maravilha e suas relações com a fé e a esperança. Uma nova dinâmica ministerial emerge como necessária para uma nova evangelização do continente que inclui o ministério dos teólogos e teólogas em relação adulta com os pastores e o magistério da Igreja.ABSTRACT: The faith of the poor has an internai logic that is necessary to deepen in order to identify the contribution that logic can offer to the processes of the new evangelization in the Church and of the continental mission proposed by Aparecida. Within the confession of faith understood in its epistemological and ethical leveis, the faith of the poor is characterized in its dimensions of minority, resistance and wonder and its relationship with faith and hope. A new ministerial dynamic emerges as necessary for a new evangelization of the continent which includes the Ministry of theologians (male and female) in an adult relation with the pastors and the Magisterium of the Church.
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Penman, Heather y Andrew Picard. "All the Single Ladies: An Investigation Into the Experiences of Single Female Pastors in the Baptist Union of New Zealand". Pacific Journal of Baptist Research 12, n.º 1 (2017): 2–17. http://dx.doi.org/10.21307/pjbr-2017-001.
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Lin, Yu-Fen. "Using a Feminist Interpretation of the Bible’s Book of Ruth to Address Taiwanese Female Pastors’ Financial Autonomy and Self-Esteem". Psychology 09, n.º 09 (2018): 2353–67. http://dx.doi.org/10.4236/psych.2018.99134.
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Poon, Vincent H. K. "Pastor Wellness among Chinese Churches: A Canadian Study". Journal of Pastoral Care & Counseling: Advancing theory and professional practice through scholarly and reflective publications 73, n.º 3 (septiembre de 2019): 169–75. http://dx.doi.org/10.1177/1542305019872435.
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This article reports the results of a survey of Canadian Chinese pastors (N = 79) regarding pastor wellness by using a 10-item questionnaire. The results indicate that 22 (27.84%) have significant concerns and 38 (48.1%) have some concerns, with females slightly more affected. Major areas of concern are marital and/or family satisfaction, physical health, problem dealing with relationships in church, and emotional health. The author discusses the implications of the results and makes some recommendations to the pastors and churches.
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Koepping, Elizabeth. "Spousal Violence among Christians: Taiwan, South Australia and Ghana". Studies in World Christianity 19, n.º 3 (diciembre de 2013): 252–70. http://dx.doi.org/10.3366/swc.2013.0060.
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Local, often unconscious, understanding of male and female informs people's views irrespective of the religious ideology of (for Christians) the imago dei. This affects church teaching about and dealings with spousal violence, usually against wives, and can be an indicator of the failure of contextualising, from Edinburgh to Tonga and Seoul to Accra, actually to challenge context and ‘speak the Word of God’ rather than of elite-defined culture. In examining five denominations (Assembly of God, Methodist, Lutheran, Roman Catholic, True Jesus Church) in Ghana, South Australia and Taiwan, ecclesial attitudes to divorce are shown to have a crucial effect on an abused woman's decision regarding the marriage, especially where stated clerical practice differs from precept. Adding that to the effects of church teaching, the side-lining of pressure and support groups and the common failure of churches to censure spousal violence of pastors, leads the writer to suggest that any prophetic voice is strangled by shameful culture-bound collusion.
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Glanz, Judy L. "Exploration of Christian Women’s Vocational Ministry Leadership and Identity Formation in Evangelical Churches on the West Coast". Christian Education Journal: Research on Educational Ministry 17, n.º 2 (11 de mayo de 2020): 325–46. http://dx.doi.org/10.1177/0739891320919422.
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This empirical research explores adult identity formation through work experiences, gaining insight into structures and practices which allow women to thrive in leadership within the evangelical church ministry context. This qualitative research explores adult identity formation and gender role stereotypes in leadership domains within the evangelical church context on the West Coast. Twenty-five ( n = 25) women in vocational church leadership, aged 25–71, revealed what impedes or contributes to female leadership adult identity formation. Key findings revealed women leaders thrive and gain identity strength through agency found in union with Christ; hold back identity components and skills available to church leadership teams to fit the male work context; contextual factors impact women’s well-being in leadership including assumptions and mindsets adverse to women leading; and lead pastors and supervisors’ beliefs about women in leadership are critical to healthy identity formation. Therefore, this research is an exploration of what experiences assist women leaders to thrive or not thrive in evangelical vocational leadership on the West Coast and how their identity in Christ empowers their leadership.
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Ofori-Amoah, Justice. "Stakeholders Opinions of Health-Related Conditions of Female Head Porters in Kumasi/Asokore Mampong". TEXILA INTERNATIONAL JOURNAL OF PUBLIC HEALTH 9, n.º 2 (30 de junio de 2021): 162–73. http://dx.doi.org/10.21522/tijph.2013.09.02.art015.
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Young Females Usually Migrate From The Northern Part Of Ghana To The South To Engage In Head Porting Business. However, The High Cost Of Rent In Urban Areas And The Poor Environmental Conditions Of Poor Urbanites Have Exposed Head Porters To Bad Conditions With Varying Implications On Health And Well-Being. This Study Examines The Health-Related Conditions Of Female Head Porters In Kumasi Through Stakeholders’ Opinions. The Study Used Quantitative Methods In Eliciting Information From Female Head-Porters In Asokore Mampong, Kumasi. In All, 100 Respondents; Comprising Relatives Of Female Head Porters And Other Opinion Leaders Such As The Assembly Member, Imam, Pastor, Teachers From Northern Ghana, Were Interviewed Through Self-Administered Questionnaires. Data Were Analyzed Using A Statistical Package For The Social Sciences (SPSS) And Excel. Economic Reasons Remain Topical For The Migration Of Females From The North To The South To Engage In Head Porting. While Many Of These Migrants Do Not Return Home, Leading To The Emergence Of Migrant Settlements In Kumasi, Others Return To Support Their Families With Their Earnings. Stakeholders Argued That Skills Development And Creating Of Entrepreneurial Ventures Are Necessary To Reduce The North-South Migratory Patterns. The Migration Of Females From The North To The South In Search Of Greener Pastures Is Likely To Continue As A Result Of Opportunity Gaps. However, Worsening Conditions Of Living May Deteriorate The Health Conditions Of Some Of The Migrants. Stakeholders Recommend A New Wave Of Solutions With Focus On Skills Development, Job Creation, And Entrepreneurial Training As Solutions.
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Holledge, Julie. "Pastor Hansen's Confirmation Class: Religion, Freedom, and the Female Body inEt dukkehjem". Ibsen Studies 10, n.º 1 (junio de 2010): 3–16. http://dx.doi.org/10.1080/15021866.2010.495528.
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Aristizábal, Edith T., Ana Liliana Ríos García y Francisco José del Pozo Serrano. "Evaluation of Mental Health, gender and social education in female inmates from the Rehabilitation Center for women El Buen Pastor in Barranquilla (Colombia)". Salud Uninorte 32, n.º 2 (15 de mayo de 2016): 256–67. http://dx.doi.org/10.14482/sun.32.2.8831.
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Tsuji, Teruyuki. "The Power of the Illegitimate". New West Indian Guide / Nieuwe West-Indische Gids 94, n.º 3-4 (25 de noviembre de 2020): 211–44. http://dx.doi.org/10.1163/22134360-bja10006.
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Abstract Based on archival research and supplemented by ethnographic observations, this article critically revisits the history of La Divina Pastora, the Madonna of Spanish origin, in colonial Trinidad, focusing on how the spirituality and materiality of two statues of this Marian image intersected, competed, and reinforced each other: a fair-complexioned La Divina Pastora in northern Trinidad, created and patronized by the Catholic central authorities; and a dark-skinned, miracle-working La Divin/Sipari Mai in Siparia, formerly a peripheral Spanish mission in southern Trinidad. Tracing the trajectory of their lives and relations reveals the complexities of the ecclesiastical history of Trinidad, unearthing the contradictions and tensions between the patriarchal making and remaking of religious orthodoxy and the popular praxis of faith for day-to-day substantive issues needing medico-spiritual solutions. Unlike extant studies, addressing the two distinct statues representing the same Marian image, this article utilizes a holistic approach in order to appreciate why and how the Madonna at Siparia emerged, survived, and thrived as a shared empowering object, despite the colonial obsession with racial-cultural purity and regimes of the boundaries of belonging. The conflicts among the Christian communities were intertwined and thwarted the Catholic central authority’s attempts to exploit La Divin/Sipari Mai’s transgressive power to attract Hindus to the Church. The tangled conflicts also created conditions in which Hindu supplications for miraculous cures persisted and thrived, despite discrimination and repression by the Catholic authorities. The incessant interactions between Catholics and Hindu devotees in Siparia led to the combination of their originally divergent practices and worldviews and the transformation of the dark-colored Madonna from La Divina Pastora to La Divin/Sipari Mai, an alternative spiritual construction that represented various maternal/female bodies, each conforming to distinct religious traditions.
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Fraser, Rachel Z., Mithila Shitut, Puja Agrawal, Odete Mendes y Sue Klapholz. "Safety Evaluation of Soy Leghemoglobin Protein Preparation Derived From Pichia pastoris, Intended for Use as a Flavor Catalyst in Plant-Based Meat". International Journal of Toxicology 37, n.º 3 (11 de abril de 2018): 241–62. http://dx.doi.org/10.1177/1091581818766318.
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The leghemoglobin protein (LegH) from soy ( Glycine max) expressed in Pichia pastoris (LegH preparation, LegH Prep) imparts a meat-like flavor profile onto plant-based food products. The safety of LegH Prep was evaluated through a series of in vitro and in vivo tests. The genotoxic potential of LegH Prep was assessed using the bacterial reverse mutation assay (Ames test) and the in vitro chromosome aberration test. LegH Prep was nonmutagenic and nonclastogenic in each test, respectively. Systemic toxicity was assessed in a 28-day dietary study in male and female Sprague Dawley rats. There were no mortalities associated with the administration of LegH Prep. There were no clinical observations, body weight, ophthalmological, clinical pathology, or histopathological changes attributable to LegH Prep administration. There were no observed effects on male reproduction in this study, but the suggestion of a potential estrous cycle distribution effect in female rats prompted a second comprehensive 28-day dietary study in female Sprague Dawley rats. This study demonstrated that female reproductive parameters were comparable between rats treated with LegH Prep and concurrent control rats. These studies establish a no observed adverse effect level of 750 mg/kg/d LegH, which is over 100 times greater than the 90th percentile estimated daily intake. Collectively, the results of the studies presented raise no issues of toxicological concern with regard to LegH Prep under the conditions tested.
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van Klinken, Adriaan S. "God’s World Is Not an Animal Farm – Or Is It? The Catachrestic Translation of Gender Equality in African Pentecostalism". Religion and Gender 3, n.º 2 (19 de febrero de 2013): 240–58. http://dx.doi.org/10.1163/18785417-00302006.
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Building on scholarly debates on Pentecostalism, gender and modernity in Africa, this article engages a postcolonial perspective to explore and discuss the ambivalent, even paradoxical nature of African Pentecostal gender discourse. It analyses the conceptualization of gender equality, in particular the attempt to reconcile the notions of ‘male–female equality’ and ‘male headship’, in a sermon series delivered by a prominent Zambian Pentecostal pastor, and argues that the appropriation and interruption of Western notions of gender equality in these sermons can be interpreted, in the words of Homi Bhabha, as a catachrestic postcolonial translation of modernity. Hence, the article critically discusses the Western ethnocentrism in some scholarly debates on gender and Pentecostalism in Africa, and points to some of the fundamental questions that Pentecostalism and its ambivalent gender discourse pose to gender-critical scholarship in the study of religion.
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Gil-Madrona, Pedro, Alejandro Prieto-Ayuso, Sheila Aparecida Dos Santos Silva, Jaime Serra-Olivares, Miguel Ángel Aguilar Jurado y Arturo Díaz-Suárez. "Habits and behaviours related to the health in adolescents during their leisure time". Anales de Psicología 35, n.º 1 (24 de diciembre de 2018): 140–47. http://dx.doi.org/10.6018/analesps.35.1.301611.
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This research attempts to determine which are the common practices related to the participation in sport and physical activities within the consumption of harmful substances in adolescents. A descriptive, correlational and transversal design was performed. A total of 1,140 subjects participated in the study (Mean age: 18.75 ± 6.35 years old; gender: male 46.7%, female 53.3%), of wich 790 were undergraduates and 350 non-undergraduates from the autonomous community of Castilla-La Mancha (Spain). It was used the Evaluation Questionnaire of the Habits related to the Health (Gil-Madrona, González-Víllora, Pastor-Vicedo, & Fernández-Bustos, 2010). Descriptive analysis revealed that a high percentage of adolescents do not practice sport regularly. The differential analysis showed significant statistical values which relates the sport habit with the tobacco, alcohol and/or drugs consumption. It was concluded that the design and development of programmes which foster physical activity are a need.
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Fidler, AE, JS Lin, S. Lun, W. Ng Chie, A. Western, V. Stent y KP McNatty. "Production of biologically active tethered ovine FSHbetaalpha by the methylotrophic yeast Pichia pastoris". Journal of Molecular Endocrinology 30, n.º 2 (1 de abril de 2003): 213–25. http://dx.doi.org/10.1677/jme.0.0300213.
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The pituitary-derived glycoprotein hormone FSH plays a central role in controlling vertebrate gonadal function. In female mammals the maturation of ovarian follicles is critically dependent upon stimulation by FSH. Moreover, injection of exogenous FSH is used extensively to stimulate increased numbers of follicles to ovulate. Structurally FSH is a heterodimeric glycoprotein composed of two non-covalently associated polypeptide subunits. The tertiary structures of both the alpha- and beta-subunits are constrained by intramolecular disulphide bonds and are post-translationally modified with two N-linked carbohydrate moieties, the structure of which appears to modulate in vivo biological activity. Here we report the expression of ovine FSH (oFSH) as a biologically active single-chain polypeptide using the methylotrophic yeast Pichia pastoris. Sequences encoding the mature oFSH alpha- and beta-proteins were fused to form a gene encoding a fusion protein with the C-terminus of the beta-chain joined to the N-terminus of the alpha-chain, with the chains separated by a two amino acid linker sequence. This fusion gene was itself fused to two alternative Pichia leader sequences (mating factor alpha and acid phosphatase) and transformed into the Pichia strains GS115 and SMD1168. The recombinant fusion protein (oFSHbetaalpha) was expressed at approximately 0.1 microg/ml in 'shake-flask' cultures. The Pichia-expressed tethered protein was biologically active in an in vitro bioassay, had a molecular mass of 28 kDa, as determined by SDS-PAGE, and bound the bovine FSH receptor with a binding profile similar to that of native oFSH.
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Stock, Joseph D., China Supakorn, Julia A. Calderon Diaz, Max F. Rothschild y Kenneth J. Stalder. "19 Overview of the National Pork Board replacement gilt feet and leg evaluation trial". Journal of Animal Science 97, Supplement_2 (julio de 2019): 11–12. http://dx.doi.org/10.1093/jas/skz122.020.
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Abstract Replacement gilt feet and leg conformation traits are subjectively evaluated at early ages (150 d) in order to select acceptable replacements. The objectives of this study were to: 1) evaluate replacement gilt feet and leg conformation (FLC) using subjective and objective measurement methods, 2) estimate objective joint angle changes over two parities, and 3) evaluate the effect of three diets differing in standardized ileal digestible (SID) lysine concentrations on FLC traits using the objective evaluation method. Crossbred Large White × Landrace gilts (n = 641) were used. Gilts were moved to GDU at 77 days-of-age and randomly allotted to three ad libitum fed dietary treatments providing similar ME but differing in SID lysine concentrations (low, medium, and high) during the grow-finisher period. All animals received common gestation and lactation diets. Feet and leg conformation traits were evaluated at 100 d, 200 d, 1st litter (392 ± 25 d) and 2nd litter (548 ± 49 d) weaning events. Subjective evaluation was done on a scale from 1 to 5. Data were analyzed using mixed linear model methods. The majority of gilts received the intermediate score (i.e. 3) when joint angles were subjectively evaluated. No differences (P ≥ 0.05) were observed for knee, front pastern and hock objective joint angles between subjective scores assigned. Differences in subjectively evaluated rear pastern (P < 0.05) were observed, where objective joint angles associated with scores of ≤ 2 and 3 were lower than score of ≥ 4. There was no interaction between dietary treatment and objective evaluation time-period for any FLC traits studied (P > 0.05). Females with greater knee, hock, front and rear pastern objective joint angles at 100 d of age, continued to have greater joint angles (0.2 ± 0.04 degrees; P < 0.001) later in life. Front and rear pastern joint angles decreased (P < 0.001) and hock joint angles increased from 100 d to end of study (P < 0.001).
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Hagley, Elmer A. C. y D. R. Barber. "EFFECT OF FOOD SOURCES ON THE LONGEVITY AND FECUNDITY OF PHOLETESOR ORNIGIS (WEED) (HYMENOPTERA: BRACONIDAE)". Canadian Entomologist 124, n.º 2 (abril de 1992): 341–46. http://dx.doi.org/10.4039/ent124341-2.
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AbstractThe fecundity of first-generation adult Pholetesor ornigis (Weed) increased when individuals were confined with flowers of creeping "Charlie" (Glechoma hederacea L.), dandelion (Taraxacum officinale Weber), and apple (Malus domesticus L.), but not with blossoms of chickweed [Stellaria media (L.) Cyrillo] or Shepherd’s purse [Capsella bursa-pastoris (L.) Medic]. Longevity of P. ornigis was little affected. The fecundity of second-generation P. ornigis increased when individuals were confined with terminal leaves of apple with honeydew of the aphid Aphis pomi DeGeer, but not when confined with terminal leaves without honeydew or with flowers of round-leaved mallow (Malva neglecta Wallr.) or red clover (Trifolium pratense L.). Longevity of P. ornigis adults also increased when they were provided with aphid honeydew. There were significant differences between the total number (oviposited and ovarian) of eggs produced by second-generation females given different food sources. Those given aphid honeydew oviposited a greater proportion of their eggs than those confined with apple leaves without honeydew or with flowers of M. neglecta or T. pratense, Adult P. ornigis fed an aqueous solution of honey (50:50, v/v) lived longest and produced more eggs than those provided with any other food source.
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Zapater, Cinta, Ana Rocha, Gregorio Molés, Alessia Mascoli, Soledad Ibañez, Silvia Zanuy y Ana Gómez. "Functional Activity of Recombinant Forms of Amh and Synergistic Action with Fsh in European Sea Bass Ovary". International Journal of Molecular Sciences 22, n.º 18 (18 de septiembre de 2021): 10092. http://dx.doi.org/10.3390/ijms221810092.
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Although anti-Müllerian hormone (AMH) has classically been correlated with the regression of Müllerian ducts in male mammals, involvement of this growth factor in other reproductive processes only recently come to light. Teleost is the only gnathostomes that lack Müllerian ducts despite having amh orthologous genes. In adult teleost gonads, Amh exerts a role in the early stages of germ cell development in both males and females. Mechanisms involving the interaction of Amh with gonadotropin- and growth factor-induced functions have been proposed, but our overall knowledge regarding Amh function in fish gonads remains modest. In this study, we report on Amh actions in the European sea bass ovary. Amh and type 2 Amh receptor (Amhr2) are present in granulosa and theca cells of both early and late-vitellogenic follicles and cannot be detected in previtellogenic ovaries. Using the Pichia pastoris system a recombinant sea bass Amh has been produced that is endogenously processed to generate a 12–15 kDa bioactive mature protein. Contrary to previous evidence in lower vertebrates, in explants of previtellogenic sea bass ovaries, mature Amh has a synergistic effect on steroidogenesis induced by the follicle-stimulating hormone (Fsh), increasing E2 and cyp19a1a levels.
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Hadlow, W. J. "Carotid Body Tumor: An Incidental Finding in Older Ranch Mink". Veterinary Pathology 23, n.º 2 (marzo de 1986): 162–69. http://dx.doi.org/10.1177/030098588602300209.
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Carotid body tumors were found incidentally at necropsy in 15 ranch mink ( Mustela vison), mostly royal pastels, kept for studies on slow viral diseases. The mink, five males and ten females, were 77 to 135 months old (mean age 107 months). Loosely or firmly attached at the bifurcation of the common carotid artery, and 11 larger tumors were smooth-surfaced, discrete, pale brown, globoid masses that varied from 2.5 to 16 mm in diameter. Four tumors of microscopic size occurred in otherwise normal-looking carotid bodies. All were composed of densely packed polygonal cells disposed in sheets and cords or arranged in clusters by a reticulin meshwork rich in blood vessels. Always unilateral, the tumors had not invaded locally or metastasized. As seen in the smallest tumors, the neoplastic cells usually arose centrally in the carotid body and formed an expansive growth that replaced much of the normal parenchyma without necessarily enlarging the organ beyond normal limits. The cause of the tumors was not apparent. All tumor-bearing mink had lived at an elevation of 1,100 meters, and none had suffered from any obvious chronic cardiopulmonary disease.
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Symeonidis, Argiris, Derralynn Hughes, Linda Richfield y Atul Mehta. "Variation of Serum Lipid Profile during Enzyme Replacement Therapy, in Patients with Type 1 Gauchers Disease." Blood 108, n.º 11 (16 de noviembre de 2006): 3849. http://dx.doi.org/10.1182/blood.v108.11.3849.3849.
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Abstract Enzyme Replacement Therapy (ERT) has dramatically changed the clinical course and prognosis of patients with Gaucher disease. We have assessed the extent to which the recently defined Goals of Therapy (Pastores et al, Semin Hematol 41(suppl 5):4–14) in 9 major fields (anemia, thrombocytopenia, hepatomegaly, splenomegaly, skeletal pathology,biomarkers, pulmonary manifestations, growth and functional health and well being) were achieved in our cohort of patients with type I Gaucher disease. Fifty-seven patients (27 females, 30 males, median age at diagnosis 30 years (range 2–77 years) and at start of ERT 39 years (range 5–79 years) were assessed. The median period of ERT was 94 months (range 24–155 months). Patients on ERT for less than 2 years were excluded. Twenty five specific goals are defined within the 9 fields. The median overall success rate was 20 of 25 goals or 80% per patient (range 12–25 goals or 60–100%). The success rate for 9 goals was 100% ( normalization of hemoglobin 1 year post-splenectomy, no major bleeding 1 year after ERT start, doubling of baseline platelet count in severely thrombocytopenic patients 2 years after ERT start, maintenance of platelet count in non-thrombocytopenic patients, prevention of bone crises, reversion of hepatopulmonary syndrome and dependence on oxygen, amelioration of pulmonary hypertension and prevention of rapid deterioration of pulmonary disease and sudden death). Higher success rates were achieved for the goals related to thrombocytopenia (97.9%) and pulmonary manifestations (97%) although in the latter case the applicability was low. Lower success rates were achieved for the goals related to bone manifestations (78.7%). There was no significant difference in the success rate between males and females, splenectomised and non-splenectomised patients, and between patients treated less or more than 6 years. However patients started on ERT before the 40th year of age exhibited significantly higher success rate as compared to patients started after the 40th year (p=0.047) and there was a significant inverse correlation between overall success rate and patient’s age at treatment start (r = − 0.437). Finally, the success rate was higher among double heterozygotes, carrying the N370S mutation, as compared to patients homozygous for the N370S mutation (89.2±9.6% vs. 80.2±12.9%, p=0.016).
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Frankel, Arthur E., Jung H. Woo, Jeremy P. Mauldin, Francine M. Foss, Madeleine Duvic y David M. Neville. "An Update On The Clinical Activity Of Resimmune, a Targeted Therapy Directed To CD3 Receptor, In Patients With Cutaneous T Cell Lymphomas--CTCL". Blood 122, n.º 21 (15 de noviembre de 2013): 4381. http://dx.doi.org/10.1182/blood.v122.21.4381.4381.
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Abstract Cutaneous T cell lymphoma—CTCL is a malignancy of skin-tropic T cells. CTCL cells have ubiquitous overexpression of CD3. Although uncommon, CTCL has been estimated to affect 1,500 patients per year in the United States. There are multiple approved systemic therapies for CTCL, but responses are brief lasting months. Allogeneic stem cell transplantation may provide long-term remissions, but is suitable for only rare CTCL patients. Overall, CTCL has a long clinical course with relentless progression over months to years with estimated median survival of 3-5 years for stage IB-IIB patients. The CD3 targeted agent, Resimmune, was synthesized and prepared for clinical use. It consists of the catalytic and translocation domains of diphtheria toxin fused to two anti-human CD3 Fv fragments. DNA encoding Resimmune protein was integrated into the Pichia pastoris genome, and recombinant protein was produced in Pichia pastoris via the secretory route (Woo, Protein Expr Purif 25, 270, 2002). Protein was purified by anion exchange and size exclusion chromatography. The CD3+ Jurkat cell line incubated with Resimmune yielded an IC50 for protein synthesis inhibition of 0.017pM. The CD3- Vero cell line incubated with Resimmune showed an IC50 >10pM. Mice, rats, and monkeys given total doses of >200mg/kg over four days showed only transient transaminasemia without histopathologic tissue injury or clinical signs or symptoms (Woo, Cancer Immunol Immunother 57, 1225, 2008). In a mouse model with human CD3e transfected lymphocytes, four logs of antigen positive cells were reproducibly depleted from nodes and spleen with 100mg/kg total dose of Resimmune (Thompson, Protein Eng 14, 1035, 2001). Based on these findings, a phase 1 study was initiated and this report serves to update the results of a single cycle of Resimmune given at 2.5-11.25mg/kg 15 min IV infusion twice daily for 8 doses to 18 CTCL patients. There were 10 females and 8 males with ages 20-81 years. Two patients were naïve to systemic therapies, and all others had failed 1-4 prior treatments including interferon, bexarotene, gemcitabine, vorinostat, chlorambucil, etoposide, pralatrexate, doxil, romidepsin, methotrexate, CHOP, and brentuximab vedotin. None of the Resimmune treated CTCL patients had dose-limiting toxicities. Side effects were mild-moderate and transient with fevers, chills, nausea, transaminasemia, hypoalbuminemia, lymphopenia, reactivation of EBV and CMV, and hypophosphatemia. Toxicities responded to antipyretics, anti-emetics, albumin infusions, rituximab treatment and valgancyclovir. Among measured patients, there was a 3 log decline in normal, circulating T cells by day 5 that recovered by day 14. Because of vascular leak syndrome toxicities in non-CTCL patients, the MTD was defined as 7.5mg/kg x 8 doses. Cmax ranged from 1.9-40.7ng/mL and half-life from 5-66min. Pretreatment anti-DT titers were 0.9-251mg/mL and day 30 post-therapy increased to 5-4059 mg/mL. 17 CTCL patients were evaluable for response. There were six responses for a response rate of 35%. There were four CRs (24% CR rate). Three of the CRs are over 4-years duration. Patients with IB or IIB disease and mSWAT<50 had an overall response rate of 86% and CR rate of 56%. The long time required to convert from a PR to a CR in the absence of any additional therapy beyond the four treatment days suggest an additional anti-tumor mechanism beyond immunotoxin-induced killing such as immunomodulation. Accrual of patients with mSWAT scores of 50 or less is ongoing. Disclosures: Woo: Angimmune: Patents & Royalties, Research Funding. Foss:celgene: Honoraria, Research Funding; millenium: Honoraria, Membership on an entity’s Board of Directors or advisory committees; eisai: Membership on an entity’s Board of Directors or advisory committees; spectrum: Research Funding; merck: Research Funding; seattle genetics: Research Funding. Neville:Angimmune: Employment, Equity Ownership, Patents & Royalties.
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Giraldo, Pilar, Marcio M. Andrade, Blanca Medrano, Pilar Alfonso, Pilar Irún, Koldo Atutxa, Angeles Fernandez-Galan et al. "Substrate Reduction Therapy With Miglustat In Type 1 Gaucher Disease In Spain. Nine Years Outcomes Update On ZAGAL Study". Blood 122, n.º 21 (15 de noviembre de 2013): 4713. http://dx.doi.org/10.1182/blood.v122.21.4713.4713.
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Substrate reduction therapy (SRT) has showed as an useful therapy in type 1 GD patients with mild or moderate disease. The main limitation to use miglustat has been the gastrointestinal adverse events. Since 2004 we have conducted the ZAGAL (Zavesca en Gaucher Leve) study for monitoring the real-life use of miglustat in Spanish adult patients with mild-to moderate disease. The study included GD1 patient’s naïve to therapy as well as patients who have previously been treated with ERT. For follow-up, the therapeutic goals for GD therapy by Pastores GM et al were applied. To date a total of 351 GD1 patients have been diagnosed in Spain (FEETEG unpublished. 2013); from 2004 until 2013, 53 of them have been exposed of miglustat (15.1%). In 16 patients (30.2%) miglustat was the first line of therapy and the remaining 38 switched from ERT. Currently 37 patients (mean age 43.6 y, range 22-83) 50.9% females, are on miglustat therapy (20 at least for 5 years and 13 during more than 8 years). Related to efficacy, the therapy permit to achieve a stable hemoglobin concentration level and spleen reduced volume, but we recorded a decrease of absolute platelet count in 15 patients (28.3%) (mean: 35x109/L, range: 10-86x109/L). Related to biomarkers changes an increase in CT activity was observed in 56.6% of patients (mean: 2,448 nmol/mL.h, range 135-13,687) and 43.4 % for CCL18/PARC (mean: 250 ng/mL, range: 19-1016). Seventeen patients (32.1%) had transitory gastrointestinal disturbances. Sixteen patients (30.2%) discontinued therapy: one of them for pregnancy, two by bone crisis, two by weight loss, one for bad compliance and ten by gastrointestinal discomfort or intolerance (18.8%). 60% of patients has a fine tremor in first months on therapy. 4 died by non-related causes (2 cancer, 1 hearth attack, 1 liver failure), Conclusion The long term follow-up of GD patients treated with Miglustat shows that more than 69% had achieved and maintains the therapeutic goals. A high individual variability had been observed related to miglustat gastrointestinal intolerance apparently no related with GBA genotype, gender and age, but possibly associated with disacaridases inhibition and food habits. Disclosures: No relevant conflicts of interest to declare.
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Nadasya, Ogiska Chaherfa, Johanes Nugroho Eko Putranto, I. Ketut Sudiana y Agus Subagjo. "THE PROFILE OF CORONARY HEART DISEASE PATIENTS IN DR SOETOMO GENERAL HOSPITAL". Majalah Biomorfologi 31, n.º 1 (29 de enero de 2021): 6. http://dx.doi.org/10.20473/mbiom.v31i1.2021.6-12.
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Background Coronary heart disease is a deadly disease for both men and women. Risk factors for coronary heart disease include age, sex, hypertension, diabetes mellitus, dyslipidemia. The incidence of coronary heart disease is not uniform thus here we reported the profile of coronary heart disease patients in Soetomo General Hospital Objective To analyze the profile of coronary heart disease patients in RSUD dr. Soetomo from February 2018 until September 2018. Materials and Methods A descriptive research based on the medical records patients was done Result There are 65 male patients (76%) and 20 female patients (24%). There are 58% patients aged 50-60 years (49 people), 24% patients aged more than 60 years old (21 people) and 18% patients less than 50 years old (15 people). Types of patients' occupations include 42% public servants (36 people), 36% private employees (31 people), 9% housewives (8 people), 5% retirees (3 people), 3% entrepreneurs (2 people), 1% teachers (1 person), 1% drivers (1 person) , 1% fishermen (1 person), 1% pastor (1 person) 1% merchant (1 person). The main complaints of patients included chest pain (40% or 34 cases), shortness of breath (23.5% or 20 cases),PCI pro staging therapy (4.6% or 4 cases), thump chest (1.2% or 1 case), lower right abdominal pain (1.2% or 1 case), right leg pain (1.2% or 1 case), nausea (1.2% or 1 case), vomiting (1.2% or 1 case), cough (1.2% or 1 case), dysentery (1.2% or 1 case) and no complaints (23.5% or 20 cases). Inpatients with coronary heart disease in Dr. Soetomo General Hospital have a history of hypertension (30.6% or 38 people), heart disease (22.6% or 28 people), diabetes mellitus (21.9% or 26 people), smoking (5.6% or 7 people), dyslipidemia (3.2% or 4 people), stroke (2.4% or 3 people) ), pulmonary TB (0.8% or 1 person), COPD (0.8% or 1 person) and no history of disease (12.9% or 16 people). Fifty-two patients had blood sugar levels of ≥100 mg / dl with a data percentage of 61%. While 16 other patients had blood sugar levels <100 mg / dl with a data percentage of 19%. And the remaining 17 patients did not get data with a percentage of 20% Conclusion We found 85 patients, predominantly males of 50-60 age group. The commonest occupation of these patients is public servant, and they came with major complaints of chest pain with past history of hypertension and high blood levels.
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Shi, H. y J. Zheng. "First Report of Soybean Cyst Nematode (Heterodera glycines) on Tobacco in Henan, Central China". Plant Disease 97, n.º 6 (junio de 2013): 852. http://dx.doi.org/10.1094/pdis-10-12-0926-pdn.
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Soybean cyst nematode (SCN) (Heterodera glycines) commonly infests soybean (Glycine max), but has also been reported to infest haricot bean, mung bean, adzuki bean, some species of Lespedeza and Melilotus (3), purple deadnettle (Lamium purpureum), henbit (Lamium amplexicaule), field pennycress (Thlaspi arvense), and shepherd's-purse (Capsella bursa-pastoris) (4). During 2009 to 2011, a survey for plant parasitic nematodes on tobacco was made in Xuchang, Henan Province, central China. Thirty six percent of 50 tobacco fields showed yellowing symptoms, and females and cysts of cyst-forming nematode were observed in the yellowing tobacco roots. The cysts were characterized by a lemon shape, with posterior protuberance, ambifenestrate, bullae, and underbridge present. The key morphometrics of cysts were fenestra length (38 to 44 μm) and width (34 to 40 μm), vulval silt (41 to 50 μm), and underbridge length (73 to 99 μm), all of which were similar to SCN (1). DNA was extracted by putting a single cracked cyst collected from the tobacco root to a 0.2-ml Eppendorf tube containing 10 μl double distilled water, 8 μl 10 × PCR Buffer (Mg–), and 2 μl of proteinase K (600 μg/ml) and frozen at –70°C for 30 min, then incubated at 65°C for 1 h and at 95°C for 10 min. After centrifugation at 12,000 rpm for 2 min, the DNA suspension was used for PCR amplification. Primers TW81 (5′-GTTTCCGTAGGTGAACCTGC-3′) and AB28 (5′-ATATGCTTAAGTTCAGCGGGT-3′) were used to amplify the rDNA internal transcribed spacer (ITS) region, and a PCR fragment of 1,030 bp was obtained. The sequence (GenBank Accession No. JX561139) showed 99% similarity to H. glycines strain Hg1-Ark1 (EF611124). Duplex PCR containing the universal primers D2A (5′-ACAAGTACCGTGAGGGAAAGTTG-3′), D3B (5′-TCGGAAGGAACCAGCTACTA-3′) and SCAR primers SCNFI (5′-GGACCCTGACCAAAAAGTTTCCGC-3′), SCNRI (5′-GGACCCTGACGAGTTATGGGCCCG-3′), obtained a 477-bp fragment, which is specific for SCN populations (2). Based on both morphological and molecular identification, the populations of cyst-forming nematodes on tobacco from Henan, China were confirmed as SCN. Pathogenicity tests were conducted on 30 each of 50-day-old tobacco and 5-day-old soybean plants (one plant per pot), respectively, by adding 2 ml of a suspension of 1,000 eggs and J2 of cysts collected from tobacco roots. After 35 days, 20 to 35 white females could be detected in each of the tobacco roots, and the yellowing symptom on almost all of tobacco plants was observed. Although infection on soybean plants was observed, the nematodes infected in roots was just 10 to 20 per pot, and they all stayed in the infective J2 stage. Except for one J3 until 48 dpi, no mature females could be found, and the nematode population could not reproduce on soybean tested. This suggests that the cyst nematode population from tobacco is a new pathotype of SCN. To our knowledge, this is the first report of SCN parasitized on tobacco in naturally infected fields, which is a potential threat to tobacco growth and should attract worldwide attention. References: (1) R. H. Mulvey. Can. J. Zool. 50:1277, 1972. (2) S. Ou et al. Nematology 10:397, 2008. (3) R. D. Riggs. In: Biology and Management of the Soybean Cyst Nematode, p. 107-114, 1992. (4) R. Venkatesh et al. Weed Technol. 14:156, 2000.
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Saadoun, D., M. Vieira, M. Vautier, X. Baraliakos, I. Andreica, J. A. P. Da Silva, M. Sousa et al. "POS0055 SARS-COV-2 OUTBREAK IN AUTOIMMUNE DISEASES: THE EURO-COVIMID STUDY". Annals of the Rheumatic Diseases 80, Suppl 1 (19 de mayo de 2021): 233–34. http://dx.doi.org/10.1136/annrheumdis-2021-eular.3368.
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Background:Coronavirus disease 2019 (COVID-19), has raised several questions in patients with immune-mediated inflammatory diseases (IMID). Whether the seroprevalence and factors associated with symptomatic COVID-19 are similar in IMID patients and in the general population is still unknown.Objectives:To assess the serological and clinical prevalence of COVID-19 in European IMID patients, along with the factors associated with its risk and the impacts the pandemic had on the IMID management.Methods:Prospective multicentre cross-sectional study among patients with five IMID (i.e. systemic lupus erythematous, Sjögren’s syndrome, rheumatoid arthritis, axial spondylarthritis or giant cell arteritis) from six tertiary-referral centers from France, Germany, Italy, Portugal, Spain and United Kingdom. Demographics, comorbidities, IMID, treatments, flares and COVID-19 details were collected. Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) serological tests were systematically performed.Results:Between June 7 and December 8, 2020, 3028 patients were included (median age 58 years, 73.9% females). SARS-CoV-2 antibodies were detected in 166 (5.5%) patients. Symptomatic COVID-19 was seen in 122 patients (prevalence: 4.0%, 95% CI 3.4-4.8%); 23 (24.2%) of them were hospitalized and four (3.2%) died. In multivariate logistic regression analysis, symptomatic COVID-19 was more likely to be observed in patients with higher levels of C-reactive protein (OR: 1.18; 95% CI 1.05-1.33; p = 0.006), and increased with the number of IMID flares (OR: 1.27; 95% CI 1.02-1.58; p = 0.03). Conversely, it was less likely to occur in patients treated with biological therapy (OR: 0.51; 95% CI 0.32-0.82; p = 0.006). During the pandemic, at least one self-reported disease flare was seen in 654 (21.6%) patients. Also, 519 (20.6%) patients experienced changes in their treatment, with 125 of these (24.1%) being due to COVID-19.Conclusion:The SARS-CoV-2 prevalence in IMID patients over the study period seems to be similar to that of the general population1. The IMID inflammatory status seems to be independently associated with the development of COVID-19.References:[1]Pollán M, Pérez-Gómez B, Pastor-Barriuso R, Oteo J, Hernán MA, Pérez-Olmeda M, et al. Prevalence of SARS-CoV-2 in Spain (ENE-COVID): a nationwide, population-based seroepidemiological study. Lancet Lond Engl. 2020 Aug 22;396(10250):535–44.Disclosure of Interests:None declared.
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Dallagiacoma, G., T. Buzzegoli, M. Karner, P. Matzneller, B. Raffeiner y C. Dejaco. "AB0752 CHRONIC RECURRENT MULTIFOCAL OSTEOMYELITIS: A SINGLE-CENTER CASE SERIES". Annals of the Rheumatic Diseases 80, Suppl 1 (19 de mayo de 2021): 1404.2–1404. http://dx.doi.org/10.1136/annrheumdis-2021-eular.4048.
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Background:Chronic recurrent multifocal osteomyelitis (CRMO) is a chronic autoinflammatory disease that primarily affects the skeleton of children and adolescents in the absence of an infectious etiology[1]. CRMO lesions presentation varies widely ranging from episodic bone pain to growth disturbance; lytic and sclerotic bone lesions can be found on X-ray, however magnetic resonance imaging is very useful for evaluating the extent of disease and follow-up [2].Objectives:To report demographic, clinical and laboratory characteristics and response to therapy in a single center Italian cohort of CRMO patients.Methods:We reviewed retrospectively the clinical records of seven patients affected by CRMO diagnosed between 2008 and 2019 at rheumatologic service of South Tyrol region in Italy.Results:We identified 7 patients with CRMO, 4 were female patients, median age of onset of symptoms was seven years. Median delay in diagnosis was seven months; all patients had bone pain as initial symptom and 6 patients presented joint swelling. Median number of lesions was two; all patients had a recurrent pattern, 4 patient had multifocal distribution and 5 had appendicular skeleton involvement. None of our patients had antinuclear antibodies or HLA-B27 positivity. Mean erythrocyte sedimentation rate was 52 mm/h and C-reactive protein 1,96 mg/dL. Regarding other organs involvement one patient presented palmoplantar pustulosis, one psoriatic arthritis and one psoriasis guttata; three patient referred familiarity for psoriasis. Histopathological diagnosis was confirmed in 3 patients. NSAIDs were used in six patients, methotrexate in two patients and bisphosphonates in 6 patients. Among biological DMARDs Adalimumab was used in two patients, one patient was treated subsequently with Secukinumab and Ustekinumab. 3 patients achieved remission (Table 1).Table 1.Demographic, clinical and laboratory characteristics of patients with chronic recurrent multifocal osteomyelitis.Total (n=7)Demographics Female (%)4 (57) Age at disease onset, years, median (range)7 (6-24) Delay in diagnosis, months, median (range)7 (2-14) Follow-up, months, median (range)69 (11-151)Initial symptoms Bone pain, n (%)7 (100) Swelling, n (%)5 (71) Limp, n (%)3 (43) Fever, n (%)1 (14)Clinical features Number of lesions, median (range)2 (1-10) Axial skeleton involvement, n (%)2 (29) Appendicular skeleton involvement, n (%)5 (71)Distribution of involvement Femur, n (%)3 (43) Radius/ulna, n (%)2 (29) Humerus, n (%)1 (14) Tibia/fibula, n (%)5 (5) Tarsal bones, n (%)1 (14) Others, n (%)3 (43)Laboratory tests Hemoglobin, g/dL, mean ± SD13.1±0.6 Leukocytes × 103/mm3, mean ± SD8.48 ±1.7 Platelets × 103/mm3, mean ± SD384±130 Erythrocyte sedimentation rate mm/h, mean ± SD52±37 C-reactive protein, mg/dL, mean ± SD1.96±2.35 Positive antinuclear antibodies, n (%)0 (100) HLA-B27 positive, n (%)0 (100)Comorbidities Any type of autoimmunity, n (%)2 (29) Others, n (%)3 (43) Histological confirmation, n (%)3 (43)Treatment NSAIDs, n (%)6 (86) Glucocorticoids, n (%)0 (0) Bisphosphonates, n (%)6 (86) TNF blocking agents, n (%)2 (29) Biological DMARDs, n (%)1 (4) Methotrexate, n (%)2 (29) Antibiotics, n (%)3 (43) Reached remission, n (%) 3 (43)Conclusion:CRMO remains a rare diagnosis. From our experience most of the patients had delay in diagnosis, laboratory tests showed mild elevation of inflammatory parameters, was found association with psoriatic arthritis and psoriasis, remission was achieved with combination of bisphosphonate and immunosuppressive therapy in less than half of the cohortReferences:[1]A. Taddio, F. Zennaro, S. Pastore, e R. Cimaz, «An Update on the Pathogenesis and Treatment of Chronic Recurrent Multifocal Osteomyelitis in Children», Pediatr. Drugs, vol. 19, n. 3, pagg. 165–172, giu. 2017.[2]S. J. Menashe et al., «The Many Faces of Pediatric Chronic Recurrent Multifocal Osteomyelitis (CRMO): A Practical Location- and Case-Based Approach to Differentiate CRMO From Its Mimics», J. Magn. Reson. Imaging JMRI, pag. e27299, ago.2020Disclosure of Interests:None declared
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Ugarte-Gil, M. F., R. V. Gamboa Cárdenas, C. Reategui Sokolova, V. Pimentel-Quiroz, M. Medina Chinchon, C. Elera-Fitzcarrald, J. Alfaro Lozano et al. "SAT0237 THE SYSTEMIC LUPUS INTERNATIONAL COLLABORATING CLINICS (SLICC) FRAILTY INDEX (SLICC-FI) PREDICTS DAMAGE ACCRUAL IN SYSTEMIC LUPUS ERYTHEMATOSUS (SLE) PATIENTS. DATA FROM A LATIN AMERICAN MESTIZO COHORT". Annals of the Rheumatic Diseases 79, Suppl 1 (junio de 2020): 1061.1–1062. http://dx.doi.org/10.1136/annrheumdis-2020-eular.3997.
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Background:The Systemic Lupus International Collaborating Clinics (SLICC) Frailty Index (SLICC-FI) has been developed as a predictor of outcomes in SLE patients1-3. However, it needs to be validated in several populations.Objectives:To evaluate the SLICC-FI as a predictor of future damage accrual in systemic lupus erythematosus (SLE) patients.Methods:Patients from a single-center prevalent cohort were included. Damage accrual was defined as the increase in SLICC/American College of Rheumatology (ACR) damage index (SDI) scores between the baseline and last visits. The SLICC-FI was measured at baseline. Univariable and multivariable negative binomial regression were performed to determine the association between the baseline SLICC-FI (per 0.05 increase) and damage accrual during follow-up, adjusted for sex, age at diagnosis, socioeconomic status, disease duration, SLE Disease Activity Index 2000 (SLEDAI-2K), SDI, prednisone daily dose, antimalarial and immunosuppressive drug use at baseline, and duration of follow-up.Results:Of the 265 patients included, 248 (93.6%) were female with mean (SD) age 35.1 (13.6) years at diagnosis. At baseline, mean (SD) SLE disease duration was 7.3 (6.5) years, SDI was 1.1 (1.3) and SLEDAI-2K was 5.3 (4.6). The mean (SD) baseline SLICC-FI was 0.22 (0.05). After a mean (SD) of 5.2 (2.2) years of follow-up, the SDI increased in 126 (47.5%) patients, and the final mean (SD) SDI score was 1.7 (1.7). Higher SLICC-FI scores at baseline predicted greater damage accrual in the univariable analysis [Incidence Rate Ratio (IRR)=1.283, (CI95% 1.072-1.536); p=0.007]. The SLICC-FI remained associated with damage accrual in the multivariable model, after adjustment for possible confounders [IRR= 1.224 (CI95% 1.007-1.488); p=0.042].Conclusion:The SLICC-FI predicts damage accrual in prevalent SLE, supporting the relevance of this index in the evaluation of SLE patients. This is the first study validating the SLICC-FI in South American populationReferences:[1]Legge A, Kirkland S, Rockwood K, et al. Construction of a Frailty Index as a Novel Health Measure in Systemic Lupus Erythematosus. J Rheumatol. 2020; 47: 72-81[2]Legge A, Kirkland S, Rockwood K, et al. Evaluating the Properties of a Frailty Index and Its Association With Mortality Risk Among Patients With Systemic Lupus Erythematosus. Arthritis Rheumatol. 2019; 71: 1297-107[3]Legge A, Kirkland S, Rockwood K, et al. Prediction of Damage Accrual in Systemic Lupus Erythematosus Using the Systemic Lupus International Collaborating Clinics Frailty Index (SLICC-FI). Arthitis Rheumatol. Epub ahead of print 2019 Oct 21.Disclosure of Interests:Manuel F. Ugarte-Gil Grant/research support from: Jannsen, Pfizer, Rocío Violeta Gamboa Cárdenas Grant/research support from: Pfizer, Cristina Reategui Sokolova: None declared, Victor Pimentel-Quiroz: None declared, Mariela Medina Chinchon: None declared, Claudia Elera-Fitzcarrald Consultant of: Tecnofarma, Jose Alfaro Lozano Speakers bureau: Lilly, Zoila Rodriguez Bellido: None declared, Cesar Pastor Asurza: None declared, Risto Perich Campos Consultant of: Pfizer, Speakers bureau: Pfizer, Graciela S Alarcon: None declared
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Pimentel-Quiroz, V., A. Sánchez-Torres, C. Reategui Sokolova, R. V. Gamboa Cárdenas, C. Sánchez-Schwartz, M. Medina Chinchon, F. Zevallos Miranda et al. "THU0316 VALIDATION OF ACR/EULAR PROVISIONAL CLASSIFICATION CRITERIA FOR ANCA-ASSOCIATED VASCULITIS IN A LATIN-AMERICAN TERTIARY CENTER". Annals of the Rheumatic Diseases 79, Suppl 1 (junio de 2020): 387.2–387. http://dx.doi.org/10.1136/annrheumdis-2020-eular.5092.
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Background:There is lack studies about performance of new criteria set for ANCA-Associated Vasculitis (AAV) in Latin-America.Objectives:To validate the new classification criteria for AAV in a real-life cohort of patients with these conditions.Methods:We performed a review of medical records from January 1990 to December 2019 at Hospital Nacional Guillermo Almenara Irigoyen from Peru. AAV was diagnosed by experienced rheumatologists based on the ACR 1990 criteria, Chapel Hill 2012 consensus, EMEA criteria and their experience and clinical acumen. Granulomatosis with polyangiitis (GPA), microscopic polyangiitis (MPA) and eosinophilic granulomatosis with polyangiitis (EGPA) were diagnosed. Renal limited vasculitis was considered as MPA. To evaluate the performance of the new criteria, we classified all patients using “former criteria set” (including the 1990 ACR criteria for GPA and EGPA and the 1994 Chapel Hill Consensus Conference for MPA) and the EMEA (European Medicines Agency) criteria set. At the same time, we classified all patients using the ACR/EULAR Provisional criteria (new criteria set). The values for sensitivity, specificity and level of agreement (using Cohen’s kappa) of all sets of criteria were calculated using the clinical diagnosis as gold standard.Results:Two hundred twelve patients were identified; 12 of them were excluded (eight did not have ANCA and four had incomplete data). Female/male ratio was 1.9:1 [130 (65%)/70 (35%)] and their mean (SD) age at diagnosis was 59.3 (12.6) years. One hundred fifty-four (77%) had MPA, 41 (20.5%) GPA and 5 (2.5%) EGPA. One hundred ninety-six patients had ANCA-IIF results [p-ANCA: 131 (66.8%), c-ANCA: 43 (21.9%), negative-ANCA: 22 (11.3%)] and 190 patients had ANCA-ELISA results [MPO: 129 (67.9%), PR3: 37 (19.5%), negative-ANCA: 24 (12.6%)]. Type of diagnosis according to criteria set used is depicted in Table 1. The new criteria set had better agreement (kappa: 0.653) than the EMEA criteria (kappa: 0.506) and the former criteria set (kappa: 0.305). Performance of the criteria sets is depicted in Table 2.Table 1.Type of AAV according to criteria set used.TYPE OF AAVClinical diagnosisFormer criteriaNew criteriaEMEAcriteriaMPA, n (%)154 (77)76 (38)137 (68.5)110 (56.0)GPA, n (%)41 (20.5)30 (15)39 (19.5)39 (19.5)EGPA, n (%)5 (2.5)2 (1)4 (2)2 (1.0)Not classifiable, n (%)NA92 (46)20 (10)44 (22.0)PAN5 (2.5)PAN: Polyarteritis nodosa. NA: Not applicable.Table 2.Performance of the different criteria sets in AAV patients.DIAGNOSISCRITERIA SETSESPKappaMPAFormer49.4100.00.309EMEA69.993.90.471New87.093.50.713GPAFormer68.398.70.744EMEA92.799.40.938New80.596.20.781EGPAFormer40.0100.00.565EMEA40.0100.00.565New60.099.50.659SE: Sensitivity. SP: Specificity.Conclusion:The ACR/EULAR Provisional Criteria for AAV have better agreement with the clinical diagnosis of AAV in Latin-American patients from a real-life cohort.Disclosure of Interests:Victor Pimentel-Quiroz: None declared, Alfredo Sánchez-Torres: None declared, Cristina Reategui Sokolova: None declared, Rocío Violeta Gamboa Cárdenas Grant/research support from: Pfizer, César Sánchez-Schwartz: None declared, Mariela Medina Chinchon: None declared, Francisco Zevallos Miranda: None declared, Erika Noriega: None declared, Jose Alfaro Lozano Speakers bureau: Lilly, Jorge-M Cucho-V: None declared, Zoila Rodriguez Bellido: None declared, Cesar Pastor Asurza: None declared, Eduardo Acevedo-Vásquez: None declared, Risto Perich Campos Consultant of: Pfizer, Speakers bureau: Pfizer, Graciela S Alarcon: None declared, Manuel F. Ugarte-Gil Grant/research support from: Jannsen, Pfizer
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Oyler-McCance, Sara J., Judy St. John, Fritz L. Knopf y Tom W. Quinn. "Population Genetic Analysis of Mountain Plover Using Mitochondrial DNA Sequence Data". Condor 107, n.º 2 (1 de mayo de 2005): 353–62. http://dx.doi.org/10.1093/condor/107.2.353.
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Abstract Mountain Plover (Charadrius montanus) distribution and abundance have been reduced drastically in the past 30 years and the conversion of shortgrass prairie to agriculture has caused breeding populations to become geographically isolated. This, coupled with the fact that Mountain Plovers are thought to show fidelity to breeding grounds, leads to the prediction that the isolated breeding populations would be genetically distinct. This pattern, if observed, would have important management implications for a species at risk of extinction. Our study examined genetic variation at two mitochondrial regions for 20–30 individuals from each of four breeding sites. We found no evidence of significant population differentiation in the data from the control region or the ATPase 6/8 region. Nested-clade analysis revealed no relationship between haplotype phylogeny, and geography among the 47 control region haplotypes. In the ATPase 6/8 region, however, one of the two clades provided information suggesting that, historically, there has been continuous range expansion. Analysis of mismatch distributions and Tajima's D suggest that the Mountain Plover underwent a population expansion, following the Pleistocene glacial period. To explain the lack of detectable genetic differentiation among populations, despite their geographic isolation and fidelity to breeding locations, we speculate that there is sufficient female-mediated gene flow to homogenize gene pools among populations. Such gene flow might ensue if pair bonds are formed in mixed flocks on wintering grounds rather than on the summer breeding grounds. Análisis Genéticos de Poblaciones de Charadrius montanus Usando Secuencias de ADN Mitocondrial Resumen. La distribución y la abundancia de Charadrius montanus se han reducido drásticamente desde hace 30 años y las poblaciones han quedado más aisladas geográficamente debido a la transformación de las praderas de pastos cortos a tierras agrícolas. Estos cambios, combinados con el hecho de que se cree que C. montanus presenta fidelidad a sus áreas de nidificación, sugieren que las poblaciones reproductivas aisladas podrían ser distintas genéticamente. De observarse este patrón, tendría consecuencias importantes para el manejo de esta especie en peligro de extinción. En nuestro estudio, investigamos el patrón de variación genética en dos regiones mitocondriales en 20–30 individuos de C. montanus provenientes de cuatro sitios de nidificación. No encontramos evidencia de diferencias poblacionales significativas en los datos de la región de control, ni en la región de ATPasa 6/ 8. Un análisis de clados anidados reveló que no hay ninguna relación entre haplotipos filogenia y geografía entre los 47 haplotipos de la región de control. Sin embargo, en la región ATPasa 6/8, uno de los dos clados proveyó información que sugiere que la especie ha aumentado históricamente su rango de distribución. Análisis de distribuciones “mismatch” y de la D de Tajima sugieren que la población se expandió después del período glacial del Pleistoceno. Para explicar la falta de diferenciación genética entre las poblaciones, a pesar de su aislamiento geográfico y de la fidelidad a sus sitios de nidificación, especulamos que el flujo de genes es controlado por las hembras de la población de tal modo que los acervos génicos son bastante homogéneos entre las poblaciones. Dicho flujo de genes podría ocurrir si se formaran las parejas en las bandadas mixtas en el invierno, no en el verano cuando están en sus áreas de nidificación.
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Acosta, M. E., L. Gómez-Lechón, O. Compán, S. Pastor, C. A. Montilla-Morales, O. Martínez González, A. I. Turrión, J. Del Pino y C. Hidalgo. "AB0543 CLINICAL CHARACTERISTICS OF A GROUP OF CHRONIC GRAFT-VERSUS-HOST DISEASE PATIENTS WITH POSITIVE AUTOIMMUNITY." Annals of the Rheumatic Diseases 79, Suppl 1 (junio de 2020): 1568.1–1568. http://dx.doi.org/10.1136/annrheumdis-2020-eular.1871.
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Background:Graft-versus-host disease (GVHD) is a commonly severe multiorgan complication in patients undergoing allogeneic transplantation of hematopoietic progenitors. Its chronic form reflects a complex immune response with different degrees of inflammation, immune dysregulation and fibrosis. In some chronic graft-versus-host disease (cGVHD) patients, positive antibodies have been detected, which represent the presence of immune activity and suggest the possible involvement of B lymphocytes in the disease etiopathogenesis, but their clinical utility is controversial.Objectives:To describe the clinical characteristics of a group of cGVHD patients with positive autoimmunity treated in a multidisciplinary consultation of Rheumatology-Dermatology- Hematology of GVHD.Methods:Observational and retrospective study to describe the clinical characteristics of the patients with positive autoimmunity collected in the database of the multidisciplinary consultation of GVHD. The variables reviewed for this study, in addition to the demographic ones, were type of antibody, disease causing the transplant, presentation, severity and type of involvement. The statistical analysis was done with Epi-info 7.2.2.6.Results:Only 16 (16%) of the 100 patients included in the database had positive autoimmunity. Twelve (75%) tested positive to ANA, although 5 (31.25%) in a lower titer (1/80). The most common immunofluorescence pattern was the nucleolar in 88.89% (66.67% nucleolar and 22.22% nucleolar + cytoplasmic). Other antibodies detected were: 6 anti-Ro52, 2 anti-dsDNA, 1 anti-RP155, 1 anti-Fibrillarin, 1 anti-SAE1, 1 p-ANCA and 1 anti-NOR-90. The mean of age was 51.31±14.03 years. As for sex 4 (25%) were female and 12 (75%) were men. The most frequent disease that caused the transplant was acute myeloid leukemia (58.3%). Ten (62.5%) patients presented de novo cGVHD, 1 (6.25%) progressive and 5 (31.25%) quiescent. The time since receiving the transplant until the first visit was 14 to 79 months. Ten (62.5%) patients had nonspecific symptoms (arthralgia and myalgia), 2 (12.5%) edema, 8 (50%) contractures, 8 (50%) fasciitis and 6 (37.5%) eosinophilia. Eight (50%) patients had ocular involvement and 6 (37.5%) of the oral mucosa in the form of dry syndrome (Sjögren-like syndrome). Ten (62.5%) patients had limitation of joint mobility detected by the range of motion scale (ROM), of which 6 were mild and 4 moderate. Only 5 (31.25%) patients had general condition impairment. As for the skin involvement 10 (62.5%) patients had sclerodermiform involvement (8 of them being eosinophilic fasciitis- like), 2 (12.5%) lichenoid, and 3 (18.5%) mixed (sclerodermiform + lichenoid). Only 1 patient didn´t meet diagnostic criteria for GVHD. The sclerodermiform was the most common type of involvement in the positive ANA patients. Regarding the severity according to the of the American National Institute of Health (NIH) classification: 8 (50%) had serious affectation, 5 (31.25%) moderate and 2 (12.5%) mild, with 4 (25%) exitus.Conclusion:In our cohort of patients with cGVHD, serum detection of autoantibodies is uncommon, being the ANA with nucleolar pattern the most frequent. Although the small sample size does not allow correlations with the clinical variables it´s worth highlighting a greater positivity of autoantibodies in the sclerodermiform skin forms.References:[1]Kuzmina Z et al. Clinical significance of autoantibodies in a large cohort of patients with chronic graft-versus-host disease defined by NIH criteria. Am J Hematol. 2015 February; 90(2): 114–119.[2]Rhoades R, Gaballa S. The Role of B Cell Targeting in Chronic Graft-Versus-Host Disease, Biomedicines 2017, 5, 61: 2-10Disclosure of Interests:Maria Elisa Acosta: None declared, Luis Gómez-Lechón: None declared, Olga Compán: None declared, Sonia Pastor: None declared, Carlos A. Montilla-Morales: None declared, Olga Martínez González: None declared, Ana Isabel Turrión: None declared, Javier del Pino Grant/research support from: Roche, Bristol, Consultant of: Gedeon, Cristina Hidalgo: None declared
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Lukina, Elena, Judith Peterschmitt, Nora Watman, Marta Dragosky, Marcelo Iastrebner, Gregory Pastores, Elsa Avila Arreguin et al. "Eliglustat Tartrate, a Novel Investigational Oral Substrate Reduction Therapy for Gaucher Disease Type 1: Updated Phase 2 Results." Blood 116, n.º 21 (19 de noviembre de 2010): 3791. http://dx.doi.org/10.1182/blood.v116.21.3791.3791.
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Abstract Abstract 3791 Background: Gaucher disease type 1 (GD1), an inherited lysosomal storage disorder, is characterized by a deficiency of acid β-glucosidase and accumulation of glucosylceramide in lysosomes causing organomegaly, thrombocytopenia, anemia, and bone disease. Eliglustat tartrate (formerly Genz-112638) is a novel, specific inhibitor of glucosylceramide synthase under development as an oral substrate reduction therapy for the treatment of GD1. Purpose: To report updated efficacy and safety observations in GD1 patients after 2 years of treatment with eliglustat tartrate in an ongoing Phase 2 clinical trial. Methods: This is an open-label, uncontrolled, multicenter, Phase 2 clinical trial of eliglustat tartrate (50 or 100 mg bid, depending on trough plasma level of drug) in 26 previously untreated adults with GD1. Entry criteria required that patients have splenomegaly with thrombocytopenia (platelet count: 45,000 to 100,000 mm3) and/or anemia (hemoglobin: 8.0–10 g/dL, females; 8.0–11 g/dL, males). Efficacy results included changes from baseline in hemoglobin and platelet levels, spleen and liver volumes, biomarkers, bone mineral density (BMD), and other skeletal findings. Hematologic and visceral parameters were assessed centrally every 3 to 6 months; MRI, DXA, and X-rays were performed yearly and reviewed centrally. Achievement of Gaucher disease therapeutic goals for hemoglobin, platelet counts, and organ volume also was assessed at 2 years. Results: Thirty-month hematologic, organ volume, and biomarker data will be available for presentation. Six of the 26 enrolled patients discontinued the Phase 2 study. Results (mean changes from baseline ± SD) are currently available in up to 20 patients who completed 2 years of treatment with eliglustat tartrate. For these patients, hemoglobin level increased by 2.1±1.5 g/dL (11.2±1.6 to 13.3±1.5 g/dL), and platelet count increased by 81.5±56.0% (67,900±20,900/mm3 to 119,200±42,400/mm3). Spleen volume (as multiples of normal, MN) decreased by 52.4±10.7% (17.95 MN to 8.14 MN), and liver volume decreased by 23.9±12.8% (1.69 MN to 1.24 MN). Mean chitotriosidase and CCL18 decreased by 75.4% and 75.2%, respectively. Through 2 years, no bone crises or reductions in mobility were reported. Femur MRI showed improvement of the dark marrow signal in 8/18 patients, indicating reduction of the infiltration of the bone marrow by Gaucher cells; the rest of the patients remained stable (10/18 patients). In addition, there were no new lytic lesions or bone infarcts; existing lytic lesions remained stable, and of 7 existing infarcts, 1 improved and 6 remained stable. Mean lumbar spine BMD increased by 7.8±10.6% (P=0.010), DXA T-Score by 0.6±0.8 (P=0.012), and DXA Z-Score by 0.6±0.7 (P=0.003), with major gains among osteoporotic/osteopenic patients. After 2 years, most patients met short-term therapeutic goals published by Pastores et al (Semin Hematol 2004;41[suppl 5]:4–14); more patients met goals for hemoglobin (95%), liver volume (95%), and spleen volume (90%) than for platelet count (60%). Overall, 85% (17/20) of patients met established therapeutic goals for ≥3 of 4 parameters after 2 years. Eliglustat tartrate was well tolerated in this trial up to 2 years. Most adverse events (AEs) were mild and unrelated to treatment. The most common AEs reported during 2 years were viral infections (6 patients), and urinary tract infections, increased blood pressure, and abdominal pain (3 patients each). Eight drug-related AEs, all mild, occurred in 6 patients. Summary/Conclusions: In this Phase 2 study, eliglustat tartrate has shown promising efficacy as a potential oral substrate reduction therapy for GD1. After 2 years, patients with GD1 treated with eliglustat tartrate continued to show improvements in hematologic, organ volume, and bone parameters with a safety profile that supports ongoing treatment. Three controlled Phase 3 studies are underway: one in untreated patients (ENGAGE), one in patients switching from enzyme replacement therapy (ENCORE), and another that compares different dose regimens of eliglustat (EDGE). Disclosures: Lukina: Genzyme Corporation: Honoraria. Peterschmitt:Genzyme Corporation: Employment. Pastores:Amicus: Research Funding; Actelion: Research Funding; Biomarin: Research Funding; Genzyme Corporation: Research Funding; Shire HGT: Research Funding; Protalix: Research Funding. Kaper:Genzyme Corporation: Employment. Haque:Genzyme Corporation: Employment. Puga:Genzyme Corporation: Employment.
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Mupangwa, Terence y Sophia Chirongoma. "The challenges of being a female pastor: A case of the Apostolic Faith Mission in Zimbabwe". HTS Teologiese Studies / Theological Studies 76, n.º 2 (23 de septiembre de 2020). http://dx.doi.org/10.4102/hts.v76i2.5838.
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The focus of this article is to highlight some of the inherent gender injustices experienced by the female pastors within the Apostolic Faith Mission in Zimbabwe (AFMZ). Drawing insights from the field research conducted in pursuance of a doctoral programme, the study foregrounds some of the barriers that women have had to endure when it comes to the issue of being ordained as a pastor. The article also interrogates the reasons used as a basis to exclude female pastors from the key decision-making bodies and to deny them the opportunity to preach at the national conference, which is the biggest gathering within the AFMZ. This is a qualitative study utilising interviews, focus group discussions and the observation method. The main findings emerging from this study reveal that whilst some positive changes have been made towards the inclusion of women in the pastoral ministry, however, there are still many gaps needing urgent attention before the AFMZ becomes a gender-inclusive and gender-equitable faith community.Contribution: This article foregrounds the challenges faced by female pastors in the AFMZ. It advocates for gender mainstreaming and gender inclusive policies in the AFMZ leadership structures. This is in sync with the focus of this collection, for which the main thrust is on women and religious leadership.
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Lin, Yu-Fen, Chi-Sing Li, Beverly Irby y Genevieve Brown. "Exploring Asian Female Pastors' Leadership Roles in the Church: Using Deborah's Story". Qualitative Report, 8 de diciembre de 2014. http://dx.doi.org/10.46743/2160-3715/2010.1355.
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Women in many Christian cultures are told that men are strong and should lead the church. Consequently, some women rationalize that they should not assume top leadership roles in the church. When they do assume such roles, many female pastors experience challenges. The purpose of our qualitative case study was to give voice to Asian female pastors (AFPs) by having them share challenges they experienced in the Taiwanese Presbyterian Church and relate those challenges to the experiences of Deborah in the biblical story found in Judges 4 and 5. Reported in this paper are the results of focus groups centered on a feminist commentary of Deborah's story. The voices of the AFPs speak to reconstruct traditional patriarchal theological thought.
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Mensire, Josephine, Bernard Gechiko Nyabwari y Paul Mulwa Kyalo. "EXECUTION OF SENSITIZATION PROGRAMMES OF ADVENTIST RELIEF AGENCY ON FEMALE CIRCUMCISION IN NYAMIRA CONFERENCE OF SEVENTH-DAY ADVENTISTS IN NYAMIRA COUNTY, KENYA". European Journal of Social Sciences Studies 6, n.º 4 (17 de junio de 2021). http://dx.doi.org/10.46827/ejsss.v6i4.1088.
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The purpose of this study was to examine the extent to which sensitization programmes of Adventist Relief Agency on female circumcision have been executed in Nyamira Conference of the Seventh-day Adventists in Nyamira County, Kenya. This study adopted a theoretical framework based on social change, social control theories. This study adopted mixed methods approach which includes both quantitative and qualitative methods which encompassed concurrent triangulation. Concurrent triangulation enabled the researcher to adopt descriptive survey research design. The target population in this study was 7 Conference management staff, 3 ADRA programme implementation officers, 60 church pastors and 700 church lay leaders. The sample size consisted of 18 church pastors and 210 lay leaders which was 30% of the target population whereas all the 7 Nyamira Conference management staff members and the 3 ADRA programme implementation officials were purposively included in the study. The study used questionnaires and oral interviews to collect data from the respondents. A pilot study was conducted for reliability and validity of the research instruments. The instruments were piloted in the churches within Nyamira Conference whose pastors and lay leaders did not participate in the study utilizing simple random sampling to select respondents. To ensure reliability of the findings, the data was subjected to cronbanch alpha index. The Cronbach alpha coefficient of 0.7878 was obtained and this implied that the research instruments were reliable and therefore the researcher adopted the research instruments. It was established that there were sensitization programmes on female circumcision in Nyamira County. Based on the findings of this study, it can be concluded that there is need to support the sensitization programmes of Adventist Relief Agency on female circumcision in Nyamira Conference of the Seventh-day Adventists in Nyamira County. Based on the findings of this study it was recommended that the Nyamira Conference management of the Seventh Day Adventist church should strive to encourage and support the sensitization programmes by the Adventist Relief Agency on female circumcision in the area of jurisdiction.
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Chinyamurindi, Willie y Reuben Rashe. "Called to the ministry: Narratives of career choice amongst female pastors in South Africa". SA Journal of Industrial Psychology 47 (11 de febrero de 2021). http://dx.doi.org/10.4102/sajip.v47i0.1810.
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De Beer, Sanrie y Julian Müller. "Using stories to assist storytelling in a pastoral setting: Four female pastors in dialogue with Mary Magdalene". HTS Teologiese Studies / Theological Studies 65, n.º 1 (3 de marzo de 2009). http://dx.doi.org/10.4102/hts.v65i1.149.
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Sometimes we need a source of encouragement for restoring our own lives, to help us re-create ourselves. Using text as narrative texts opens up a multitude of possibilities in the work with clients in therapy. The story of Mary Magdalene told in John 20:11–18 is considered to be a healing story. This article aims to retell the story of her encounter with the resurrected Jesus, using the Gospel of Mary as an enlightening intertext. Because the story of Mary Magdalene’s encounter with Jesus is used as a healing story, the basic principles of transformative narrative theory are considered to be useful in the analysis of this text. Mary Magdalene’s story is then discussed with three female pastors of the Netherdutch Reformed Church of Africa. The research opened up a discussion about spirituality. This article would be incomplete without reflecting on the spirituality stories of the group of co-researchers.
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Baloyi, M. E. "Pastoral care and the agony of female singleness in the African christian context". In die Skriflig/In Luce Verbi 44, n.º 3/4 (25 de julio de 2010). http://dx.doi.org/10.4102/ids.v44i3/4.169.
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In our society the norm is thatevery adult should get married one day. This could imply thatunmarried people do not feel welcome either in the community or the church. They may feel neglected or even like outcasts. It is a pity that the church, which also finds itself within the community, is composed of people who still continue to havethe kind of attitude that excludes singles, even inside church circles. While churches run programmes that have a strong emphasis on marriage and family life, nothing is being doneto address singleness and its related problems. As a result, singles often regard themselves as unimportant and worthless. This article is aimed at un-covering the role of the church through its leadership (pastors in particular) to assist and helpto redeem the damaged image and self-esteem that singles may have in their respective communities and churches. The article focuses on singles in the African church and society. It is crucial that a church programme of care and counselling be structured in order to minister to persons who are separated, divorced, widowed or never married for whatever reason.
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Human, Heidi y Julian C. Müller. "Sexual abuse: A practical theological study, with an emphasis on learning from transdisciplinary research". HTS Teologiese Studies / Theological Studies 71, n.º 3 (11 de marzo de 2015). http://dx.doi.org/10.4102/hts.v71i3.3025.
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This article illustrates the practical usefulness of transdisciplinary work for practical theology by showing how input from an occupational therapist informed my understanding and interpretation of the story of Hannetjie, who had been sexually abused as a child. This forms part of a narrative practical theological research project into the spirituality of female adult survivors of childhood sexual abuse. Transdisciplinary work is useful to practical theologians, as it opens possibilities for learning about matters pastors have to face, but may not have knowledge about. A short retelling of Hannetjie’s story is given to provide information about the context of the research. Next, the transdisciplinary process that was followed is mentioned, and the questions that the transdisciplinary team had to respond to are discussed. Following that, I focus more specifically on the occupational therapist’s answers, and the knowledge gained from her contribution, as an example of how a co-researcher from a divergent discipline can inform a theological study. In this case, knowledge was shared about sensory integration and how the brain processes traumatic stimuli, such as sexual abuse. Lastly, the interrelationship between Hannetjie’s body stories, mind stories and spirit stories is discussed to show how the learning received from occupational therapy affected my thinking about Hannetjie’s stories and the relationships between them. Thus, it is concluded that transdisciplinary work has great value for practical theology, especially in the pastor’s daily work with people who are struggling with difficult stories, because we cannot listen to people’s spirit stories in isolation. They are inextricably intertwined with all our stories about ourselves.
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Witt, Andreas, Elmar Brähler, Paul L. Plener y Jörg M. Fegert. "Different Contexts of Sexual Abuse With a Special Focus on the Context of Christian Institutions: Results From the General Population in Germany". Journal of Interpersonal Violence, 27 de noviembre de 2019, 088626051988854. http://dx.doi.org/10.1177/0886260519888540.
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Recent revelations of the extent of sexual abuse in the Roman Catholic Church in Germany and the United States have once more triggered the debate about sexual abuse. Those inquiries identify cases that are known to authorities or have been recorded in these institutions. However, to assess the full magnitude of the problem, data beyond recorded or known cases are needed, as it can be assumed that a vast number of cases are not reported and are hence not included in such file reviews. Therefore, representative surveys are needed. The aim of the present study was to examine the prevalence of sexual abuse by priests and in different contexts in the German population based on a representative sample. A total of 2,510 participants (54.3% female, M = 48 years) were retrospectively asked about different experiences, offenders, contexts, and so on, of child sexual abuse using questions that were used to assess child sexual abuse in prior surveys and the Childhood Trauma Questionnaire (CTQ). In sum, 0.21% ( n = 7) of the participants reported child sexual abuse by a priest or pastor. 0.16% reported child sexual abuse in an institution of the Roman Catholic Church. Results also indicated that victims of sexual abuse by priests and pastors reported rather severe types of sexual abuse based on the CTQ in comparison with other contexts, such as schools. Extrapolating the data for the population, it can be assumed that the estimated number of victims is much higher than those identified by research based on recorded cases.
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Lagat, Rebecca J. "A voice from the margins: Investigating the African Adventist rationale on the quest for female ordination". Verbum et Ecclesia 37, n.º 1 (31 de marzo de 2016). http://dx.doi.org/10.4102/ve.v37i1.1585.
Texto completoResumen
Discussions surrounding women�s ordination reached a peak with the 60th General Conference Session (GCS 2015) of the Seventh-day Adventist (SDA) Church. A report compiled by a section of delegates from the East-Central Africa Division � Biblical Research Committee indicated that this continent was not yet ready to ordain women as pastors. In light of the report, this article aims to investigate the rationale of such a stark decision. Firstly, the report shows that African Adventist women theologians were omitted from the discussions � a lack of good will from the church leadership towards the females as the majority of the membership. Secondly, the decision against ordination of women is suspect and biblically inconclusive. Through an overview of literature on a biblical missional design, the article postulates: Contextualisation and theologising are necessary for Africa, but the SDA Church must remember that globally both theology and culture are subject to the biblical guidelines, and thus to God�s missio Dei as well.Intradisciplinary and/or interdisciplinary implications: This article balances cultural contextualism and gender relations � challenging a cultural bias through a missional hermeneutic. This can lead to fairer representation of African women in Adventist church structures and reroute the equality discourse in light of the missio Dei. The study intersects with cultural theory, social analysis and biblical hermeneutics.�