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1

Nishinaka, Anri, Koki Nitta, Takashi Seki, Hideaki Hara, and Masamitsu Shimazawa. "The Changes in Blood Flow Seen in the Eye after Foot Acupuncture Treatment in Mice." Evidence-Based Complementary and Alternative Medicine 2020 (April 6, 2020): 1–6. http://dx.doi.org/10.1155/2020/6405471.

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Acupuncture is used to treat a wide variety of eye diseases, although there is little evidence about the effects of acupuncture treatment and the mechanisms responsible for them. Foot acupuncture treatment has effects in both mice and humans. The purpose of this study was to investigate the effects of acupuncture treatment on ocular blood flow in mice. We evaluated ocular blood flow in C57BL/6J mice after foot acupuncture treatment using laser speckle flowgraphy. The mean blur rate, which is an index of blood flow velocity, was increased in the foot acupuncture group. Our results showed that,
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2

Huang, Chang, Jiankang Liang, Qicheng Zhang, and Tao Lu. "A Comparative Study on “Mai” and “Blood Vessels” in Early Chinese and Western Medicine: Based on Hippocratic Corpus and Cauterization Canon of the Eleven Vessels of the Foot and Forearm." Evidence-Based Complementary and Alternative Medicine 2019 (June 9, 2019): 1–8. http://dx.doi.org/10.1155/2019/7826234.

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This study compared the theory describing the “four pairs of blood vessels” in the Hippocratic Corpus with the description of vessels (Mai, 脉) in the Cauterization Canon of the Eleven Vessels of the Foot and Forearm. The two theories are comparable because of the time period in which they were written, the similarities between the descriptions of the Mai and blood vessels, and the treatment methods for symptoms corresponding to their dysfunctions. We discovered that the Mai theory and the blood vessel theory in the Hippocratic Corpus were conceived with similar motivations. They had a lot of c
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3

Kim, Young-Kook, and Juhyun Song. "Potential of Glucagon-Like Peptide 1 as a Regulator of Impaired Cholesterol Metabolism in the Brain." Advances in Nutrition 11, no. 6 (2020): 1686–95. http://dx.doi.org/10.1093/advances/nmaa080.

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ABSTRACT Cerebral vascular diseases are the most common high-mortality diseases worldwide. Their onset and development are associated with glycemic imbalance, genetic background, alteration of atherosclerotic factors, severe inflammation, and abnormal cholesterol metabolism. Recently, the gut–brain axis has been highlighted as the key to the solution for cerebral vessel dysfunction in view of cholesterol metabolism and systemic lipid circulation. In particular, glucagon-like peptide 1 (GLP-1) is a cardinal hormone that regulates blood vessel function and cholesterol homeostasis and acts as a c
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4

Chylińska-Wrzos, Patrycja, Marta Lis-Sochocka, and Barbara Jodłowska-Jędrych. "Use of propolis in difficult to heal diabetic wounds. Short review." Polish Journal of Public Health 127, no. 4 (2017): 173–75. http://dx.doi.org/10.1515/pjph-2017-0037.

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Abstract According to WHO, about 347 million of people worldwide suffer from diabetes. Diabetes has complex etiology, and the consequences of this illness are seen in the morphological changes of many tissues and organs i.e. neuropathy leading to the risk of diabetic foot. Due to the diabetic condition, injuries to blood vessels in diabetic foot can be classified as chronic. This is because such wounds remain unresponsive to treatment for months or even years. There are many therapeutic methods employed in treating such injuries. These involve the use of silver, iodine or multi-antibiotic prep
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5

Гвазава and T. Gvazava. "Technique of Atypical Amputation of the Foot in Patients with a Complicated Course of Diabetic Foot Syndrome." Journal of New Medical Technologies 22, no. 3 (2015): 43–49. http://dx.doi.org/10.12737/13297.

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Abstract. Introduction. Diabetes mellitus is one of the most common and socially important diseases in the world. The diabetic foot syndrome is one of the most complex diseases with a view to pathogenesis and one of the most serious complications of diabetes mellitus. This syndrome is characterized by disorders and changes of all structures of lower extremities, causes the ulcerous and necrotic processes. At the current moment, a traditional method in treatment of complications of the diabetic foot syndrome is amputation of lower extremities. Due to the large number of postoperative complicati
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6

Polanco, Joshua Benjamín Andrés, Maria Jaqueline Mamprim, Jeana P. Silva, Letícia R. Inamassu, and Bruno Cesar Schimming. "Computed tomographic and radiologic anatomy of the lower respiratory tract in the red-foot tortoise (Chelonoidis carbonaria)." Pesquisa Veterinária Brasileira 40, no. 8 (2020): 637–46. http://dx.doi.org/10.1590/1678-5150-pvb-6587.

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ABSTRACT: The diagnosis of several diseases in chelonians is a challenge in the veterinary clinic, because a detailed physical examination with auscultation and palpation is difficult due the presence of carapace and plastron. Imaging analysis such as radiography and computed tomography (CT) have been shown to be beneficial for diagnosis, prognosis and treatment in numerous animal species. Thus, this study aimed to identify and describe the structures of the lower respiratory tract in red-foot tortoises, by computed tomography, radiography and gross anatomy in twelve red-foot tortoises (Chelon
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7

Davydkin, V. I. "PROFESSOR IVAN NIKIFOROVICH PIKSIN (to the 85th anniversary of the birth)." Grekov's Bulletin of Surgery 178, no. 6 (2020): 80–82. http://dx.doi.org/10.24884/0042-4625-2019-178-6-80-82.

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The article is dedicated to the 85th birthday of the famous scientist, honored worker of science of the Russian Federation, honored worker of science of the Republic of Mordovia, honored doctor of the Republic of Mordovia, laureate of State prize, head of the scientific-pedagogical surgical school, doctor of medical Sciences professor Piksin Ivan Nikiforovich. I. N. Piksin is the author of fundamental studies of the biomedical effects of quantum radiation at the molecular, cellular and organismal levels in patients with acute destructive diseases of the lungs, purulent-septic diseases, lactati
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8

Mamchur, V. I. "Pharmacology of treatment of vascular diseases with the help of endothelioprotectors." Infusion & Chemotherapy, no. 3.2 (December 15, 2020): 199–201. http://dx.doi.org/10.32902/2663-0338-2020-3.2-199-201.

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Background. Endothelioprotectors (EP) are a group of drugs with different pathogenetic mechanisms of action that prevent disruption and/or restore the structural and functional properties of vascular endothelium. EP are mainly used in the treatment and prevention of cardiovascular and cerebrovascular diseases and their complications.
 Objective. To describe the role of EP in modern therapy of vascular diseases on the example of L-arginine (Tivortin, “Yuria-Pharm”).
 Materials and methods. Analysis of literature data on this topic.
 Results and discussion. The endothelium can be
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9

Munir, Muneeza, Shabir Hussain, Rubi Anwar, Muhammad Waqas, and Jigar Ali. "The Role of Nanoparticles in the Diagnosis and Treatment of Diseases." Scientific Inquiry and Review 4, no. 3 (2020): 14–26. http://dx.doi.org/10.32350/sir/2020/43/981.

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Nanotechnology is involved in the diagnosis and treatment of infectious and inflammatory diseases. It has shown a good role in regenerating, restoring and repairing damaged body parts, such as the heart, lungs and blood vessels. Nanoparticles (NPs) are helpful in osteoblasts formation and also used in the treatment of bone inflammation, skin infections, tuberculosis (TB), human immunodeficiency virus (HIV), Parkinson’s disease, atherosclerosis, cardiovascular and pulmonary diseases. They also assist the anti-inflammatory drugs in penetrating the skin. Platinum nanoparticles (NP) are used in bo
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10

Pratiwi, Ika Nur, Lingga Curnia Dewi, and Ika Yuni Widyawati. "Buerger exercise dan edukasi perawatan kaki pada penderita diabetes dan hipertensi dalam upaya menurunkan resiko gangguan vaskular." Transformasi: Jurnal Pengabdian Masyarakat 16, no. 2 (2020): 121–32. http://dx.doi.org/10.20414/transformasi.v16i2.2679.

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[Bahasa]: Hipertensi dan diabetes melitus (DM) yaitu penyakit kronis yang membutuhkan perawatan berkelanjutan sebagai upaya untuk mengendalikan tekanan darah dan kadar gula darah. Keduanya memiliki kerentanan mengalami gangguan vaskular sehingga aliran sirkulasi darah tidak lancar, rentan mengalami gangguan ekstremitas kaki yang bermanifestasi menjadi sumbatan pada pembuluh darah, ulkus bahkan amputasi. Situasi pandemi akibat COVID-19, mengharuskan penderita tetap berada dirumah saja terutama pada individu dengan komorbid seperti hipertensi dan DM yang beresiko lebih tinggi tertular Covid-19,
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11

He, Chunjinig. "Effect of Shock Wave on Vascular Lesions in Diabetic Rats." Pain Physician 5, no. 22;5 (2019): E505—E510. http://dx.doi.org/10.36076/ppj/2019.22.e505.

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Background: Diabetes is one of the most common diseases in today’s society. Diabetes can cause multiple vascular lesions in the body, renal insufficiency, blindness, and so on. However, the evidence concerning the role of extracorporeal shock wave therapy in diabetic vascular disease is insufficient. Objectives: Observation of the effect of shock wave on vascular lesions in diabetic rats. Study Design: This study used an experimental design. Setting: The research took place in the laboratory research center at The Third Military Medical University. Methods: Eighteen healthy adult male Sprague
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12

Guo, Shiqi, Guozhen Zhao, Xue-ming Chen, et al. "Effect of transcutaneous electrical acupoint stimulation on bone metabolism in patients with immobilisation after foot and ankle fracture surgery: a randomised controlled trial study protocol." BMJ Open 12, no. 9 (2022): e056691. http://dx.doi.org/10.1136/bmjopen-2021-056691.

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IntroductionFracture is a disease with a high incidence worldwide. Foot and ankle fractures are common among fractures of the lower extremities. Foot and ankle fractures usually require surgical fixation and a period of fixed treatment, which can lead to decreased bone density. Although transcutaneous electrical acupoint stimulation (TEAS) is widely used for movement system diseases, there is minimal evidence to show the effectiveness of TEAS on patients after surgical fixation of ankle and foot fractures. This trial aims to evaluate whether TEAS can reduce bone loss in patients with immobilis
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13

Dong, Tao, Yu-Wen Cheng, Fei Yang, et al. "Chronic Stress Facilitates the Development of Deep Venous Thrombosis." Oxidative Medicine and Cellular Longevity 2015 (2015): 1–8. http://dx.doi.org/10.1155/2015/384535.

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The increasing pressure of modern social life intensifies the impact of stress on the development of cardiovascular diseases, which include deep venous thrombosis (DVT). Renal sympathetic denervation has been applied as one of the clinical approaches for the treatment of drug-resistant hypertension. In addition, the close relationship between oxidative stress and cardiovascular diseases has been well documented. The present study is designed to explore the mechanism by which the renal sympathetic nerve system and the oxidative stress affect the blood coagulation system in the development of DV
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14

Kacmaz, Fehmi, Adnan Kaya, Muhammed Keskin, et al. "Clinical outcomes of extended endovascular recanalization of 16 consecutive Buerger’s disease patients." Vascular 27, no. 3 (2018): 233–41. http://dx.doi.org/10.1177/1708538118805623.

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Objective Buerger’s disease is one of the worst diseases causing peripheral artery occlusions (especially lower extremity) with increased morbidity and mortality. Endovascular treatment of the diseased arteries gains preference over bypass surgery nowadays. Here, we aimed to present the clinical outcomes of 16 consecutive Buerger’s disease patients underwent extended endovascular recanalization which is a new technique to restore direct blood flow to at least one foot artery, with the performance of angioplasty for each tibial and foot artery obstructions. Methods A total of 16 consecutive pat
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15

Yang, Yongkang, Yucong Li, Qi Pan, et al. "Tibial cortex transverse transport accelerates wound healing via enhanced angiogenesis and immunomodulation." Bone & Joint Research 11, no. 4 (2022): 189–99. http://dx.doi.org/10.1302/2046-3758.114.bjr-2021-0364.r1.

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Aims Treatment for delayed wound healing resulting from peripheral vascular diseases and diabetic foot ulcers remains a challenge. A novel surgical technique named ‘tibial cortex transverse transport’ (TTT) has been developed for treating peripheral ischaemia, with encouraging clinical effects. However, its underlying mechanisms remain unclear. In the present study, we explored the potential biological mechanisms of TTT surgery using various techniques in a rat TTT animal model. Methods A novel rat model of TTT was established with a designed external fixator, and effects on wound healing were
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16

Serrano-Coll, Héctor, and Nora Cardona-Castro. "Neuropathic ulcers in leprosy: clinical features, diagnosis and treatment." Journal of Wound Care 31, Sup6 (2022): S32—S40. http://dx.doi.org/10.12968/jowc.2022.31.sup6.s32.

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Leprosy is a neglected disease caused by Mycobacterium leprae and Mycobacterium lepromatosis, and is related to significant disabilities resulting from the neural damage generated by this mycobacteria. Neuropathic ulcers—lesions that can appear at the plantar and extra-plantar levels—are one such disability, and diagnosis requires an adequate dermatological, neurological and microbiological evaluation. The treatment of these lesions is based on a multidisciplinary approach that includes debridement of the necrotic tissue, controlling infections, reducing pressure areas, optimising blood flow,
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17

Sun, Kaiqiang, Feng Lin, Jialin Jiang, Jingchuan Sun, and Jiangang Shi. "A Novel Capsule Lumbar Interbody Fusion (CLIF) in Treating Foot Drop due to Lumbar Degenerative Diseases: a Prospective, Observational Study." Pain Research and Management 2021 (November 12, 2021): 1–11. http://dx.doi.org/10.1155/2021/6880956.

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Objective. This present study aimed to explore the clinical effects of a novel capsule lumbar interbody fusion (CLIF) on foot drop due to lumbar degenerative diseases. Methods. Between June 2018 and January 2019, a total of 27 patients admitted to our department with lumbar degenerative diseases with associated foot drop were prospectively enrolled. Given the selection of surgical technique, patients were divided into traditional TLIF group and CLIF group. We assessed patients’ neurological status using JOA and VAS score, tibialis anterior muscle strength using MMT score, diameter and hemodyna
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18

Barros, Camila D. S., Jomênica B. Livramento, Margaret G. Mouro, Elisa Mieko Suemitsu Higa, Carlos T. Moraes, and Celia Harumi Tengan. "L-Arginine Reduces Nitro-Oxidative Stress in Cultured Cells with Mitochondrial Deficiency." Nutrients 13, no. 2 (2021): 534. http://dx.doi.org/10.3390/nu13020534.

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L-Arginine (L-ARG) supplementation has been suggested as a therapeutic option in several diseases, including Mitochondrial Encephalomyopathy, Lactic Acidosis, and Stroke-like syndrome (MELAS), arguably the most common mitochondrial disease. It is suggested that L-ARG, a nitric oxide (NO) precursor, can restore NO levels in blood vessels, improving cerebral blood flow. However, NO also participates in mitochondrial processes, such as mitochondrial biogenesis, the regulation of the respiratory chain, and oxidative stress. This study investigated the effects of L-ARG on mitochondrial function, ni
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19

Hasibuan, Nelly Astuti, Hery Sunandar, Senanti Alas, and Suginam Suginam. "Sistem Pakar Mendiagnosa Penyakit Kaki Gajah Menggunakan Metode Certainty Factor." Jurasik (Jurnal Riset Sistem Informasi dan Teknik Informatika) 2, no. 1 (2017): 29. http://dx.doi.org/10.30645/jurasik.v2i1.16.

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Elephant foot disease or filariasis is a contagious disease caused by filarial worms that are transmitted through the type of mosquito. This disease is chronic and if not get treatment will result in permanent disability in the form of leg enlargement, genitals both women and men. Elephant foot disease is generally detected through blood microcopy examination. Until now it is still felt because microfilaria only appear in the blood at night for several hours (nocturnal perioicity). In addition, various methods of examination are also performed to diagnose elephantiasis diseases such as those k
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20

Martin Oliva, Xavier, and Antonio Viladot Voegeli. "Aseptic (avascular) bone necrosis in the foot and ankle." EFORT Open Reviews 5, no. 10 (2020): 684–90. http://dx.doi.org/10.1302/2058-5241.5.200007.

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Aseptic necrosis may be defined as a group of diseases that have bone necrosis as a common denominator. They usually appear in the epiphyses and in the carpal and tarsal bones. They generally appear during a growth period and principally at those skeletal points subjected to particular stress. In Müller–Weiss disease in the advanced stages, talonavicular-cuneiform arthrodesis, with or without back foot correction, is the best surgical option. In Freiberg–Kohler disease, treatment can be conservative and we can maintain the head of the metatarsal by performing a joint debridement of the metatar
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21

Reading, Stacey A., and Maggie Yeomans. "Oxygen absorption by skin exposed to oxygen supersaturated water." Canadian Journal of Physiology and Pharmacology 90, no. 5 (2012): 515–24. http://dx.doi.org/10.1139/y2012-020.

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The present study tests the hypothesis that skin on the plantar surface of the foot absorbs oxygen (O2) when immersed in water that has a high dissolved O2 content. Healthy male and female subjects (24.2 ± 1.4 years) soaked each foot in tap water (1.7 ± 0.1 mg O2·L–1; 30.7 ± 0.3 °C) or O2-infused water (50.2 ± 1.7 mg O2·L–1; 32.1 ± 0.5 °C) for up to 30 min in 50 different experiments. Transcutaneous oximetry and near infrared spectroscopy were used to evaluate changes in skin PO2, oxygenated haemoglobin, and cytochrome oxidase aa3 that resulted from treatment. Compared with the tap water condi
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22

Sani, Fakhrudin Nasrul, and Noor Fitriyani. "Rendam Kaki Rebusan Air Jahe Merah Berpengaruh terhadap Penurunan Tekanan Darah Penderita Hipertensi." Jurnal Ilmiah Kesehatan 14, no. 1 (2021): 67. http://dx.doi.org/10.48144/jiks.v14i1.534.

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Abstrak. Hipertensi merupakan kondisi dimana tekanan darah seseorang melebihi batas normal yang ditetapkan, dimana kondisi tersebut dapat menimbulkan komplikasi berupa penyakit pada organ-organ tubuh lainnya. Pengobatan hipertensi terdiri dari pengobatan farmakologi dan nonfarmakologi. Salah satu pengobatan non farmakologi adalah hidroterapi yaitu rendam kaki air hangat. Penggunaan zat kompelementer dalam hidroterapi misalnya rendam kaki rebusan air jahe merah. Tujuan penelitian untuk mengetahui pengaruh rendam kaki rebusan air jahe merah terhadap penurunan tekanan darah penderita hipertensi d
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23

Vinnik, Y. S., S. S. Dunayevskaya, and D. A. Antyufriyeva. "Grculation of microparticles of lymphocytic origin at critical ischemia of the lower extremities." Medical Immunology (Russia) 22, no. 2 (2020): 319–26. http://dx.doi.org/10.15789/1563-0625-com-1796.

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Great scientific interest to problems of obliterating atherosclerosis of vessels of the lower extremities is caused by increase in incidence of this pathology and multidisciplinary approach in diagnostics and treatment the research objective: to study interrelations between quantity of the circulating microparticles of lymphocytic origin and development of critical ischemia of the lower extremities. The executed research belonged to cohort prospective researches. Two studied groups were created: 1st group included 75 patients with ischemia IIB degrees on Pokrovsky—Fontaine's classification. Th
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McKenzie, Paula, David Sotello, Yared Hailemariam, Vipul Desai, and Brian Temple. "Aeromonas veronii septicemia in an immunocompetent patient." Southwest Respiratory and Critical Care Chronicles 1, no. 4 (2013): 50. http://dx.doi.org/10.12746/swrccc.v1i4.82.

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We present a 29-year-old healthy man who fell into an industrial auger, sustaining acrushed, open pelvic injury, multiple comminuted fractures of the right leg, and traumaticamputation of his left foot. Blood and wound cultures were positive for Aeromonasspp and vancomycin resistant Enterococcus. Treatment included cefepime, levofloxacin,daptomycin, and metronidazole. Aeromonas veronii is a Gram negative bacillus usuallyfound in fresh and brackish water in warm climates. It can cause severe skin andsoft tissue infections, typically after injured tissue is exposed to contaminated water.Aeromona
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25

Gbadamosi, I. T., N. A. Okolo, A. A. Oyagbemi, T. O. Ajibade, and T. O. Omobowale. "Antihypertensive effect of Harungana madagascariensis LAM. ex poir. On sodium fluoride-induced hypertension and Associated cardiorenal dysfunctions." Ife Journal of Science 22, no. 2 (2020): 237–49. http://dx.doi.org/10.4314/ijs.v22i2.21.

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Hypertension is an important risk factor for cardiovascular diseases, which are major causes of mortality globally. This study evaluated the antihypertensive effects of Harungana madagascariensis on sodium fluorideinduced hypertension. Twenty-five rats were randomly divided into five groups (A-E). Group A (control), received normal food and water with no treatment; Groups B to E were exposed to 300 ppm sodium fluoride (NaF). In addition, Group C was treated with 10 mg/kg enalapril, while Groups D and E were treated with 100 mg/kg and 200 mg/kg of H. madagascariensis extract, respectively. The
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Борис Р. Я., Блищак Н. Б., Михалевич М. М., Блищак Ю. З. та Покотило П. Б. "УЛЬТРАСТУКТУРНА ОРГАНІЗАЦІЯ ГЕМОМІКРОЦИРКУЛЯТОРНОГО РУСЛА ШКІРИ БІЛОГО ЩУРА НА РАННІХ ЕТАПАХ ПЕРЕБІГУ ЕКСПЕРИМЕНТАЛЬНОГО СТРЕПТОЗОТОЦИН- ІНДУКОВАНОГО ЦУКРОВОГО ДІАБЕТУ". International Academy Journal Web of Scholar 1, № 11(41) (2019): 17–22. http://dx.doi.org/10.31435/rsglobal_wos/30112019/6803.

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 This article is presented information about electron microscopic characteristic the angioarchitectonics of hemomicrocirculatory white rat skin net in experimental streptozotocin-induced diabetes mellitus. Was used in the experiment 30 adult white male rats weighing 120-130 grams, which were maintained on a standard diet, had free access to food and water under normal conditions. The insulin-dependent form of type I diabetes mellitus was modeled by a single intraperitoneal injection of streptozotocin from Sigma at a rate of 7mg per 100g of body weight of the animal (prepare
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Gubergrits, N. B., N. V. Byelyayeva, and K. Y. Linevska. "Early concepts of nutrition, digestion, diseases of the gastrointestinal tract and their treatment: from the Schola Medica Salernitana to Rokitansky and Virchow." Modern Gastroenterology, no. 5—6 (December 29, 2022): 65–68. http://dx.doi.org/10.30978/mg-2022-5-65.

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The Schola Medica Salernitana and «The Salernitan Rule of Health» are monuments of medieval medicine and pharmacy. The Schola Medica Salernitana inherited the traditions of ancient medicine. «The Salernitan Rule of Health» examines the properties of various foods, fruits, and plants and their therapeutic effects. The work was written according to the custom of that time — in verse, because advice given in poetic form is better memorized. Gaspare Aselli (1581 — 1626) was a Milanese anatomist and surgeon. When his work on the lactiferous vessels of the intestine was published (1622), there was c
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Hastuti, Mona. "EFEKTIFITAS TERAPI SPA KAKI DALAM MENURUNKAN KELUHAN NEUROPATI DIABETIK PADA PASIEN DIABETES MELLITUS." Jurnal Maternitas Kebidanan 5, no. 2 (2020): 11–20. http://dx.doi.org/10.34012/jumkep.v5i2.1255.

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Indonesia is facing diabetes mellitus disease as a pandemic global, which Indonesia is standing at 6thrank with population of the country has the most diabetes mellitus patients at the age of 20 to 79 in the world and is expected to increase by the time (IDF 2017). Peripheral vascular and sensory to motor neuropathy disease are the highest complications of diseases and frequently found in diabetes mellitus case. Diabetik foot spa is one of the therapies to boost patient’s blood circulation also provide a relax feeling for patient’s feet, therefore this activities aims to observe the effectiven
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Farràs, Marta, Jonathan Richard Swann, Ian Rowland, et al. "Impact of Phenol-Enriched Olive Oils on Serum Metabonome and Its Relationship with Cardiometabolic Parameters: A Randomized, Double-Blind, Cross-Over, Controlled Trial." Antioxidants 11, no. 10 (2022): 1964. http://dx.doi.org/10.3390/antiox11101964.

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Phenol-rich foods consumption such as virgin olive oil (VOO) has been shown to have beneficial effects on cardiovascular diseases. The broader biochemical impact of VOO and phenol-enriched OOs remains, however, unclear. A randomized, double-blind, cross-over, controlled trial was performed with thirty-three hypercholesterolemic individuals who ingested for 3-weeks (25 mL/day): (1) an OO enriched with its own olive oil phenolic compounds (PCs) (500 ppm; FOO); (2) an OO enriched with its own olive oil PCs (250 ppm) plus thyme PCs (250 ppm; FOOT); and (3) a VOO with low phenolic content (80 ppm).
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Raghav, Shraddha Singh, Bhavna Kumar, Neeraj Kumar Sethiya, and Ankur Kaul. "A Mechanistic Insight on Phytoconstituents Delivering Hypoglycemic Activity: A Comprehensive Overview." Future Pharmacology 2, no. 4 (2022): 511–46. http://dx.doi.org/10.3390/futurepharmacol2040032.

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Diabetes is a long-term (chronic), challenging lifestyle (metabolic) disorder in which the body cannot regulate the amount of sugar in the blood and majorly affecting endocrine system and metabolic functions. Its complications majorly affect the neurons (as developing neuropathy), kidney (as nephropathy), and eye (as retinopathy). Diabetes also results in other associated problems, such as diabetic foot ulcers, sexual dysfunction, heart diseases etc. In the traditional medicines, the search for effective hypoglycemic agents is a continuous and challenging approach. Plant-derived bioactives, in
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Nowak, Emilia, Dominika Psiuk, Agata Rocka, et al. "Resveratrol impacts health in patients with diabetes mellitus and other metabolic conditions." Journal of Education, Health and Sport 12, no. 11 (2022): 341–46. http://dx.doi.org/10.12775/jehs.2022.12.11.045.

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Background Resveratrol is a polyphenol with many properties, including activity against glycation, oxidative stress, inflammation, neurodegeneration, carcinogenesis and aging. It appears to be a promising compound for the prevention and treatment of metabolic diseases. The aim of this review is to summarize the results of the latest clinical trials that concern effects of resveratrol in diabetes mellitus type 1 and 2 and its complications - diabetic foot ulcers, diabetic nephropathy and non-alcoholic fatty liver disease. Aim of the study Based on in vitro studies and animal models, it has been
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32

Islam, Salman Ul, Adeeb Shehzad, Muhammad Bilal Ahmed, and Young Sup Lee. "Intranasal Delivery of Nanoformulations: A Potential Way of Treatment for Neurological Disorders." Molecules 25, no. 8 (2020): 1929. http://dx.doi.org/10.3390/molecules25081929.

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Although the global prevalence of neurological disorders such as Parkinson’s disease, Alzheimer’s disease, glioblastoma, epilepsy, and multiple sclerosis is steadily increasing, effective delivery of drug molecules in therapeutic quantities to the central nervous system (CNS) is still lacking. The blood brain barrier (BBB) is the major obstacle for the entry of drugs into the brain, as it comprises a tight layer of endothelial cells surrounded by astrocyte foot processes that limit drugs’ entry. In recent times, intranasal drug delivery has emerged as a reliable method to bypass the BBB and tr
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33

Ma, Xinran, Ling Li, Lei Zhang, et al. "Efficacy and Safety of Apatinib in Relapsed or Refractory Diffuse Large B Cell Lymphoma: An Open-Label, Single-Arm, Prospective Study." Blood 134, Supplement_1 (2019): 2873. http://dx.doi.org/10.1182/blood-2019-127912.

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Background Treatment options for relapsed or refractory diffuse large B-cell lymphoma (RR DLBCL) represent an unmet medical need. Apatinib is a new oral tyrosine kinase inhibitor mainly targeting vascular endothelial growth factor receptor 2 (VEGFR-2) to inhibit tumor angiogenesis, and has shown encouraging anti-tumor effects in multiple solid tumors. Yet clinical evidence of apatinib as a potential treatment choice for RR DLBCL remains rare. In current study, we evaluated the efficacy and safety of Apatinib for patients with RR DLBCL. Methods In this open-label, single-arm, prospective study,
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34

Xhaferi, Nusret, Antonio Gavrilovski, Marija Jakimova, Fatime Ukaj, Dea Dyla, and Skender Ukaj. "Primary Actinomycosis of the Foot in a 37-year-old female Patient: A Case Study and Review of the Literature." Albanian Journal of Trauma and Emergency Surgery 6, no. 2 (2022): 1064–68. http://dx.doi.org/10.32391/ajtes.v6i2.270.

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Abstract:
 A parasitic disease called actinomycosis occurs when bacteria spread through body tissues, causing abscesses, inflammation, and pain. It affects the skin or deeper parts of the body and can sometimes affect the blood.[1] The symptoms of actinomycosis may mimic those of other diseases or even neoplasms. Remission and exacerbation of symptoms occurring in parallel sequence with the initiation and cessation of therapy is a phenomenon that should increase suspicion of actinomycosis in any of its manifestations. [2]
 Microbiology, histopathology, and MRI revealed the presence o
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35

Morozova, Elena A., and Ekaterina V. Kurdyukova. "Relationship between the level of vitamin D in bloof flow and skin dermatosis." Russian Journal of Skin and Venereal Diseases 24, no. 4 (2021): 355–65. http://dx.doi.org/10.17816/dv77778.

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Vitamin D is vital for bone health and its deficiency deemed as a disease of the past has re-emerged as an important health concern. Thanks to modern research, the role of vitamin D has been studied in detail and goes far beyond the concepts of regulating the mineral composition of bones. A small amount of active vitamin in the form of cholecalciferol is obtained by the body with food of animal origin, in the form of ergocalciferol and previtamin D ― with food of plant origin. Another way to get vitamin D is exposure to solar radiation. Both insufficient and excessive levels of vitamin D have
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36

Leniz, Javiera, and Martin C. Gulliford. "Continuity of care and delivery of diabetes and hypertensive care among regular users of primary care services in Chile: a cross-sectional study." BMJ Open 9, no. 10 (2019): e027830. http://dx.doi.org/10.1136/bmjopen-2018-027830.

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ObjectivesExplore factors related to continuity of care and its association with diabetes and hypertensive care, and disease control.DesignCross-sectional study.SettingData from the Chilean Health National Survey 2009–2010.ParticipantsRegular users of primary care services aged 15 or older.Primary and secondary outcome measuresProportion of hypertensive and diabetic patients with a blood pressure <140/90 mm Hg and HbA1c<7.0% respectively, self-report of diagnosis, treatment and recent foot and ophthalmological exams. Associations between continuity of care, sociodemographic characteristi
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37

Varma, Dr Madhumati. "Role of Education of Diabetes to Controlling Plasma Glucose, Urea, Creatinine, Uric Acid in Central Hospital Nampula." Journal of Current Medical Research and Opinion 1, no. 09 (2018): 42–46. http://dx.doi.org/10.15520/jcmro.v1i09.110.

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Modern approaches to diabetes primarily rely upon dietary and lifestyle management, often combined with regular ongoing blood glucose level monitoring. The diabetic education is a fundamental requirement of management of non-pharmacological treatment of diabetes. Medication alone not able to control diabetes. There should be patient behavior changed from continuing learning about diet, physiology, continues learning, preventive management of complication of diabetes, knowledge of diseases, self-managing small problem and inform to medical staff, use information technology . There is fast and g
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38

Euba, G., J. Lora-Tamayo, O. Murillo, et al. "Pilot Study of Ampicillin-Ceftriaxone Combination for Treatment of Orthopedic Infections Due to Enterococcus faecalis." Antimicrobial Agents and Chemotherapy 53, no. 10 (2009): 4305–10. http://dx.doi.org/10.1128/aac.00444-09.

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ABSTRACT Serious Enterococcus faecalis infections usually require combination therapy to achieve a bactericidal effect. In orthopedic infections, the prognosis of enterococcal etiology is considered poor, and the use of aminoglycosides is questioned. The ampicillin-ceftriaxone combination has recently been accepted as alternative therapy for enterococcal endocarditis. After one of our patients with endocarditis and vertebral osteomyelitis was cured with ampicillin-ceftriaxone, we started a pilot study of orthopedic infections. Patients with infections due to E. faecalis (with two or more surgi
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39

Sharma, Sanjeev Kumar, Anjan Mukherjee, Avinash Kumar Singh, et al. "Madurella mycetomatis infection following allogenic stem cell transplantation for aplastic anemia." Mediterranean Journal of Hematology and Infectious Diseases 4, no. 1 (2012): e2012038. http://dx.doi.org/10.4084/mjhid.2012.038.

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Madurella mycetomatis is the most common fungal agent causing eumycetoma. The commonest clinical presentation of the infection is the appearance of multiple sinuses with discharge of grains, which are the colonies of the fungus. It is an emerging fungal infection among transplant recipients and has not been reported following stem cell transplantation. We report here a case of aplastic anemia who developed madura foot, caused by Madurella mycetomatis, following allogenic peripheral blood stem cell transplantation. The diagnosis was made by the examination of discharged black grains under micro
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40

Reid, Gail, Joseph P. Lynch, Michael C. Fishbein, and Nina M. Clark. "Mucormycosis." Seminars in Respiratory and Critical Care Medicine 41, no. 01 (2020): 099–114. http://dx.doi.org/10.1055/s-0039-3401992.

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AbstractMucormycosis is an infection caused by a group of filamentous molds within the order Mucorales. Infections may result from ingestion of contaminated food, inhalation of spores into the nares or lungs, or inoculation into disrupted skin or wounds. In developed countries, mucormycosis occurs primarily in severely immunocompromised hosts (e.g., those with hematological malignancies, organ transplantation, neutropenia, autoimmune disorders, or other impairments in immunity). Only 6 to 10% of cases occur in subjects with no underlying disease. In contrast, in developing countries, most case
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41

Trishin, Leonid. "Diabetic Foot." International Journal of Applied Research in Bioinformatics 10, no. 2 (2020): 38–50. http://dx.doi.org/10.4018/ijarb.2020070105.

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In the article, questions of an etymology, a pathogeny of diagnostics, and treatment of diabetic foot are considered. In addition to a reasonable diet, it is necessary to take medicine, to regularly check sugar level in blood, to train regularly, and to consult constantly with the doctor to control recovery process. Long-term and stable control of blood sugar and bringing its level to norm can considerably reduce the risk of injury of nerves, kidneys, eyes, and blood vessels.
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42

Maliutina, N. V. "Basic principles of infusion therapy: fundamentals of fluid and electrolyte balance." Infusion & Chemotherapy, no. 3.2 (December 15, 2020): 196–98. http://dx.doi.org/10.32902/2663-0338-2020-3.2-196-198.

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Background. Infusion therapy (IT) is a method of managing the functions of the organism by influencing purposefully the morphological composition and physiological properties of blood through parenteral administration of organic and inorganic solutions. The main feature of IT is that the drug completely enters the bloodstream.
 Objective. To describe the main characteristics of fluid and electrolyte balance and the IT principles.
 Materials and methods. Analysis of the literature sources on this topic.
 Results and discussion. Fluid comprises about 60 % of the human body (in chi
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43

Diongue, Khadim, Mamadou Alpha Diallo, Lamine Sarr, et al. "Pulmonary Madurella mycetomatis mycetoma secondary to knee eumycetoma, Senegal." PLOS Neglected Tropical Diseases 15, no. 3 (2021): e0009238. http://dx.doi.org/10.1371/journal.pntd.0009238.

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Mycetoma is a neglected tropical disease which is endemic in Senegal. Although this subcutaneous mycosis is most commonly found on the foot, extrapodal localisations have also been found, including on the leg, knee, thigh, hand, and arm. To our knowledge, no case of blood-spread eumycetoma has been reported in Senegal. Here, we report a case of pulmonary mycetoma secondary to a Madurella mycetomatis knee eumycetoma. The patient was a 41-year-old farmer living in Louga, Senegal, where the Sudano-Sahelian climate is characterised by a short and unstable rainy season and a steppe vegetation. He s
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Nurlaily, Ari Pebru, Meri Oktariani, and Anestasia Pangestu Mei Tyas. "OPTIMIZATION OF DSME THROUGH INCREASED KNOWLEDGE OF PREVENTION OF COMPLICATIONS AND DIABETES EMERGENCIES IN WONOREJO VILLAGE." Darmabakti Cendekia: Journal of Community Service and Engagements 3, no. 1 (2021): 29. http://dx.doi.org/10.20473/dc.v3.i1.2021.29-32.

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Background: Many elderly convey blood sugar often up and down due to lack of attention to their diet. The condition became urgent because the elderly had previously died from complications accompanied by diabetic ulcers. In the posyandu area of wonorejo healthy elderly, DM disease is one of the diseases that are quite widely suffered by its citizens. Objective: The DSME education program for cadres and the elderly at Posyandu Wonorejo aims to increase knowledge and prevent diabetes complications. Method: This DSME program was conducted in four sessions, namely, session 1 discussing basic knowl
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45

Spyridakis, Evangelos, Jeffrey S. Gerber, Emily Schriver, et al. "Clinical Features and Outcomes of Children with Culture-Negative Septic Arthritis." Journal of the Pediatric Infectious Diseases Society 8, no. 3 (2018): 228–34. http://dx.doi.org/10.1093/jpids/piy034.

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Abstract Background Septic arthritis is a serious infection, but the results of blood and joint fluid cultures are often negative in children. We describe here the clinical features and management of culture-negative septic arthritis in children at our hospital and their outcomes. Methods We performed a retrospective review of a cohort of children with septic arthritis who were hospitalized at Children’s Hospital of Philadelphia between January 2002 and December 2014. Culture-negative septic arthritis was defined as a joint white blood cell count of >50000/μL with associated symptoms, a cli
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46

Larbie, Christopher, Jeremiah Issaka, and Marina Tandoh. "Anti-diabetic effect of aqueous fruit extract of Borassus aethiopum (Mart.) in alloxan-induced diabetic rats." International Journal of Phytomedicine 8, no. 3 (2016): 384. http://dx.doi.org/10.5138/09750185.1884.

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<p>Introduction: Diabetes mellitus (DM) is a group of metabolic diseases characterized by hyperglycemia resulting from defects in insulin secretion, insulin action, or both. The chronic hyperglycemia is associated with long-term damage, dysfunction, and failure of various organs, especially the eyes, kidneys, nerves, heart, and blood vessels and is among the top ten causes of death in the world. Borassus aethiopum Mart. (family Arecaceae) is a plant species of Borassus palm found widely across Africa. It serves an important source of food, providing edible fruits, and nuts, and also has
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47

Nagaeva, Elena V. "In honor of the 85th anniversary of Vladimir Vasilyevich Potemkin." Problems of Endocrinology 64, no. 6 (2019): 412–14. http://dx.doi.org/10.14341/probl10096.

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We are celebrating the 85 anniversary and 61 years of research, pedagogical and medical activities of one of the nation’s leading endocrinologists, the promoter of academic endocrinology, the founder and the first head of the department of endocrinology of the Pirogov Russian National Research Medical University (RNIMU)
 Honored Doctor of the Russian Federation, Professor Vladimir Vasilyevich Potemkin.
 V.V. Potemkin was the first in our country who began to teach endocrinology at the department of internal diseases of the pediatric faculty of the 2nd Moscow State Medical Institute (
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48

Suarez, Maria J., and Yu Shia Lin. "1360. Prevalence of Bacteremia in Hospitalized Patients with Skin and Soft Tissue Infections (SSTI)." Open Forum Infectious Diseases 8, Supplement_1 (2021): S766. http://dx.doi.org/10.1093/ofid/ofab466.1552.

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Abstract Background Skin and soft tissue infections (SSTI) are common in outpatient and inpatient settings. The prevalence of positive blood cultures (BC) ranges from 2% to 52%. Because of the variations in published data, the exact prevalence of bacteremia in hospitalized patients with SSTI is unknown. Our objective is to determine the prevalence of bacteremia in hospitalized patients with SSTI. Methods Retrospective chart review from January 2017 to December 2018. Patients older than 18 years admitted with SSTI who required BC on admission were included. Patients who met the criteria for sys
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Ramírez-Carvajal, Lisbeth, Fayna Diaz-San Segundo, Elizabeth Ramirez-Medina, Luis L. Rodríguez, and Teresa de los Santos. "Constitutively Active IRF7/IRF3 Fusion Protein Completely Protects Swine against Foot-and-Mouth Disease." Journal of Virology 90, no. 19 (2016): 8809–21. http://dx.doi.org/10.1128/jvi.00800-16.

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ABSTRACTFoot-and-mouth disease (FMD) remains one of the most devastating livestock diseases around the world. Several serotype-specific vaccine formulations exist, but they require about 5 to 7 days to induce protective immunity. Our previous studies have shown that a constitutively active fusion protein of porcine interferon (IFN) regulatory factors (IRF) 7 and 3 [IRF7/3(5D)] strongly induced type I IFN and antiviral genesin vitroand prevented mortality in an FMD mouse model when delivered with a replication-defective adenoviral vector [Ad5-poIRF7/3(5D)]. Here, we demonstrate that pigs treate
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50

Komarova, L. N., S. A. Zvezda, E. N. Agafonova, E. S. Kolodkina, and R. I. Duboshinsky. "Varicose veins with Hallux valgus." Medical Science And Education Of Ural 21, no. 3 (2020): 99–101. http://dx.doi.org/10.36361/1814-8999-2020-21-3-99-101.

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Our research is dedicated to the combined pathology of musculoskeletal system – Hallux valgus with varicose veins of lower extremities that are common in the surgical practice. This study allowed us to estimate frequency of hallux valgus and varicose veins combined with each other and also to identify main factors that contribute to these diseases progression. Methods and principles of the research. To diagnose the combined pathology instrumental investigation (foot X-ray in two planes) was performed in 40 (36,7%) patients out of 109 that were under treatment in the surgical unit of the Genera
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