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Artículos de revistas sobre el tema "Gamma stimulations"

Autor: Grafiati

Publicado: 22 de febrero de 2025

Última modificación: 31 de julio de 2025

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1

Zhang, Jianing, Yanhuan Huang, Fuqiang Ye, Bibo Yang, Zengyong Li, and Xiaoling Hu. "Evaluation of Post-Stroke Impairment in Fine Tactile Sensation by Electroencephalography (EEG)-Based Machine Learning." Applied Sciences 12, no. 9 (2022): 4796. http://dx.doi.org/10.3390/app12094796.

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Electroencephalography (EEG)-based measurements of fine tactile sensation produce large amounts of data, with high costs for manual evaluation. In this study, an EEG-based machine-learning (ML) model with support vector machine (SVM) was established to automatically evaluate post-stroke impairments in fine tactile sensation. Stroke survivors (n = 12, stroke group) and unimpaired participants (n = 15, control group) received stimulations with cotton, nylon, and wool fabrics to the different upper limbs of a stroke participant and the dominant side of the control. The average and maximal values

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2

Suzuki, M., T. Asplund, H. Yamashita, C. H. Heldin та P. Heldin. "Stimulation of hyaluronan biosynthesis by platelet-derived growth factor-BB and transforming growth factor-β1 involves activation of protein kinase C". Biochemical Journal 307, № 3 (1995): 817–21. http://dx.doi.org/10.1042/bj3070817.

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The intracellular signal transduction pathways that mediate the stimulatory effects of platelet-derived growth factor (PDGF)-BB and transforming growth factor (TGF)-beta on hyaluronan biosynthesis in human fibroblasts were investigated. The stimulatory effects of both PDGF-BB and TGF-beta 1 were dependent on protein kinase C (PKC), since the PKC inhibitor calphostin C inhibited the stimulation by the growth factors. Direct activation of PKC by phorbol 12-myristate 13-acetate (PMA) also stimulated hyaluronan production, and the combination of either PDGF-BB or TGF-beta 1 and PMA gave an increas

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3

Hui, C. S., and W. Chen. "Effects of conditioning depolarization and repetitive stimulation on Q beta and Q gamma charge components in frog cut twitch fibers." Journal of General Physiology 99, no. 6 (1992): 1017–43. http://dx.doi.org/10.1085/jgp.99.6.1017.

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Charge movement was measured in frog cut twitch fibers with the double Vaseline-gap technique. Steady-state inactivation of charge movement was studied by changing the holding potential from -90 mV to a level ranging from -70 to -30 mV. Q beta and Q gamma at each holding potential were separated by fitting the Q-V plot with a sum of two Boltzmann distribution functions. At -70 mV Q beta and Q gamma were inactivated to 54.0% (SEM 2.2) and 82.7% (SEM 3.0) of the amounts at -90 mV. At holding potentials greater than or equal to -60 mV, more Q gamma was inactivated than Q beta, and at -30 mV Q gam

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4

Veera, Lakshmi Pabbiniddi *. Kameswari Pravallika Kotra. "Medical Devices Exhibiting the Neuromodulation Technique - A Milestone for the Treatment of Migraine." International Journal of Pharmaceutical Sciences 2, no. 6 (2024): 1320–31. https://doi.org/10.5281/zenodo.12582654.

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Migraine attack is increasing day-by-day due to the stressed conditions, increased heat, and improper daily routine schedules of the people. To protect the people from the chronic pain and intense migraine attacks, medical devices are introduced which are boon to the patients. Neuromodulation is the technique adapted to treat acute migraine and chronic attack. The medical devices are manufactured in such a way that performs either magnetic stimulations or electrical stimulations when initiated. Acute treatment and preventive treatment can be provided by using these medical devices. The differe

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5

Chen, Qi, Yue Dong, and Yan Gai. "Tactile Location Perception Encoded by Gamma-Band Power." Bioengineering 11, no. 4 (2024): 377. http://dx.doi.org/10.3390/bioengineering11040377.

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Background: The perception of tactile-stimulation locations is an important function of the human somatosensory system during body movements and its interactions with the surroundings. Previous psychophysical and neurophysiological studies have focused on spatial location perception of the upper body. In this study, we recorded single-trial electroencephalography (EEG) responses evoked by four vibrotactile stimulators placed on the buttocks and thighs while the human subject was sitting in a chair with a cushion. Methods: Briefly, 14 human subjects were instructed to sit in a chair for a durat

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6

İMDAT, Nuray Nükhet, Özlem Tuğçe ÇİLİNGİR-KAYA, Zehra Nur TURGAN ÂŞIK, et al. "Electron microscopic GABA evaluation in hippocampal mossy terminals of genetic absence epilepsy rats receiving kindling stimulations." Clinical and Experimental Health Sciences 12, no. 4 (2022): 981–87. http://dx.doi.org/10.33808/clinexphealthsci.1030132.

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Objective: The hypotheses related to the fact of epileptic mechanisms are mainly based on excitation-inhibition imbalance in central nervous system. GAERS (Genetic Absence Epilepsy Rats from Strasbourg) is a well-known animal model of absence epilepsy, and frequently used in experimental studies. In the present study, we aimed to examine possible morphological and gamma-aminobutyric acid (GABA) density changes in GAERS hippocampus after electrical kindling stimulations. Methods: All control and test group rats received 6 kindling stimulations. Rats were decapitated 1 h after the last sti

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7

Schoisswohl, Stefan, Berthold Langguth, Tobias Hebel, Mohamed A. Abdelnaim, Gregor Volberg, and Martin Schecklmann. "Heading for Personalized rTMS in Tinnitus: Reliability of Individualized Stimulation Protocols in Behavioral and Electrophysiological Responses." Journal of Personalized Medicine 11, no. 6 (2021): 536. http://dx.doi.org/10.3390/jpm11060536.

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Background: Repetitive transcranial magnetic stimulation (rTMS) is a non-invasive brain stimulation tool potentially modulating pathological brain activity. Its clinical effectiveness is hampered by varying results and characterized by inter-individual variability in treatment responses. RTMS individualization might constitute a useful strategy to overcome this variability. A precondition for this approach would be that repeatedly applied protocols result in reliable effects. The condition tinnitus provides the advantage of immediate behavioral consequences (tinnitus loudness changes) after in

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8

Hwang, Eun Jung, and Richard A. Andersen. "Effects of visual stimulation on LFPs, spikes, and LFP-spike relations in PRR." Journal of Neurophysiology 105, no. 4 (2011): 1850–60. http://dx.doi.org/10.1152/jn.00802.2010.

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Local field potentials (LFPs) have shown diverse relations to the spikes across different brain areas and stimulus features, suggesting that LFP-spike relationships are highly specific to the underlying connectivity of a local network. If so, the LFP-spike relationship may vary even within one brain area under the same task condition if neurons have heterogeneous connectivity with the active input sources during the task. Here, we tested this hypothesis in the parietal reach region (PRR), which includes two distinct classes of motor goal planning neurons with different connectivity to the visu

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9

Sudha Kumari, Lekshmy, and Abbas Z. Kouzani. "A Miniaturized Closed-Loop Optogenetic Brain Stimulation Device." Electronics 11, no. 10 (2022): 1591. http://dx.doi.org/10.3390/electronics11101591.

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This paper presents a tetherless and miniaturized closed-loop optogenetic brain stimulation device, designed as a back mountable device for laboratory mice. The device has the ability to sense the biomarkers corresponding to major depressive disorder (MDD) from local field potential (LFP), and produces a feedback signal to control the closed-loop operation after on-device processing of the sensed signals. MDD is a chronic neurological disorder and there are still many unanswered questions about the underlying neurological mechanisms behind its occurrence. Along with other brain stimulation par

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10

Farrar, WL, and A. Harel-Bellan. "Myeloid growth factor(s) regulation of ornithine decarboxylase: effects of antiproliferative signals interferon-gamma and cAMP." Blood 73, no. 6 (1989): 1468–75. http://dx.doi.org/10.1182/blood.v73.6.1468.1468.

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Abstract Colony-stimulating factors (CSFs) stimulate the activation and steady- state mRNA accumulation of an important regulatory enzyme for macromolecular synthesis, ornithine decarboxylase (ODC). Cloned murine CSF-dependent cell lines exhibited a rapid activation of ODC enzyme activity, detectable within ten minutes of stimulations with either interleukin-3 (IL-3), GM-CSF, or G-CSF. This early phase of enzyme activation did not require early protein or mRNA synthesis. The subsequent protracted rise in ODC activity occurring four to six hours after CSF treatment was dependent on increases in

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11

Farrar, WL, and A. Harel-Bellan. "Myeloid growth factor(s) regulation of ornithine decarboxylase: effects of antiproliferative signals interferon-gamma and cAMP." Blood 73, no. 6 (1989): 1468–75. http://dx.doi.org/10.1182/blood.v73.6.1468.bloodjournal7361468.

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Colony-stimulating factors (CSFs) stimulate the activation and steady- state mRNA accumulation of an important regulatory enzyme for macromolecular synthesis, ornithine decarboxylase (ODC). Cloned murine CSF-dependent cell lines exhibited a rapid activation of ODC enzyme activity, detectable within ten minutes of stimulations with either interleukin-3 (IL-3), GM-CSF, or G-CSF. This early phase of enzyme activation did not require early protein or mRNA synthesis. The subsequent protracted rise in ODC activity occurring four to six hours after CSF treatment was dependent on increases in steady-s

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12

Morré, D. J., M. Davidson, C. Geilen, et al. "NADH oxidase activity of rat liver plasma membrane activated by guanine nucleotides." Biochemical Journal 292, no. 3 (1993): 647–53. http://dx.doi.org/10.1042/bj2920647.

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The activity of a hormone- and growth-factor-stimulated NADH oxidase of the rat liver plasma membrane responds to guanine nucleotides, but in a manner that differs from that of the classic trimeric and low-molecular-mass monomeric G-proteins. In the absence of added bivalent ions, both GTP and GDP as well as guanosine 5′-[gamma-thio]triphosphate (GTP[gamma-S]) but not guanosine 5′[beta-thio]diphosphate (GDP[beta-S]) stimulate the activity over the range 1 microM to 100 microM. Other di- and tri-nucleotides also stimulate, but only at concentrations of 100 microM or higher. Added bivalent ions

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13

Vollebregt, M. M. G., A. Malfroot, M. De Raedemaecker, M. van der Burg, and J. E. van der Werff ten Bosch. "Immunodeficiency in a Child with Rapadilino Syndrome: A Case Report and Review of the Literature." Case Reports in Immunology 2015 (2015): 1–4. http://dx.doi.org/10.1155/2015/137368.

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Rapadilino syndrome is a genetic disease characterized by a characteristic clinical tableau. It is caused by mutations in RECQL4 gene. Immunodeficiency is not described as a classical feature of the disease. We present a 2-year-old girl with Rapadilino syndrome with important lymphadenopathies and pneumonia due to disseminatedMycobacterium lentiflavuminfection. An immunological work-up showed several unexpected abnormalities. Repeated blood samples showed severe lymphopenia. Immunophenotyping showed low T, B, and NK cells. No Treg cells were seen. T cell responses to stimulations were insuffic

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14

Shen, F., X. L. Xu, L. H. Graf, and A. S. Chong. "CD45-cross-linking stimulates IFN-gamma production in NK cells." Journal of Immunology 154, no. 2 (1995): 644–52. http://dx.doi.org/10.4049/jimmunol.154.2.644.

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Abstract The in vitro demonstration of the ability of NK cells to secrete cytokines prompted in vivo studies that illustrated the importance of NK cell-derived cytokines in regulating immune responses. Cross-linking of CD16 on NK cells can stimulate cytokine production. CD16-independent interactions capable of stimulating cytokine production have also been described, but molecules mediating such stimulations remain to be biochemically defined. We report here that cross-linking of CD45 specifically stimulates IFN-gamma production in human NK cells. The NK cells used were IL-2-activated adherent

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15

Zhu, Yan, Di Wu, Kewei Sun, et al. "Alpha and Theta Oscillations Are Causally Linked to Interference Inhibition: Evidence from High-Definition Transcranial Alternating Current Stimulation." Brain Sciences 13, no. 7 (2023): 1026. http://dx.doi.org/10.3390/brainsci13071026.

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(1) Background: The Go/NoGo task and color-word Stroop task were used to investigate the effect of applying different frequency bands of neural oscillations to the lDLPFC on inhibitory control modulation. (2) Methods: Participants were randomly categorized into four groups and received HD-tACS at 6, 10, and 20 Hz or sham stimulation at 1.5 mA for 20 min. All participants performed a color-word Stroop task and Go/NoGo task before and immediately after the stimulation; closed-eye resting-state EEG signals were acquired for 3 min before and after the tasks. (3) Results: There were no significant

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16

Arif, Yasra, Alex I. Wiesman, Nicholas J. Christopher-Hayes, and Tony W. Wilson. "Aberrant inhibitory processing in the somatosensory cortices of cannabis-users." Journal of Psychopharmacology 35, no. 11 (2021): 1356–64. http://dx.doi.org/10.1177/02698811211050557.

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Background: Delta-9 tetrahydrocannabinol (THC) is a major exogenous psychoactive agent, which acts as a partial agonist on cannabinoid (CB1) receptors. THC is known to inhibit presynaptic neurotransmission and has been repeatedly linked to acute decrements in cognitive function across multiple domains. Previous electrophysiological studies of sensory gating have shown specific deficits in inhibitory processing in cannabis-users, but to date these findings have been limited to the auditory cortices, and the degree to which these aberrations extend to other brain regions remains largely unknown.

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17

Guy-Grand, D., B. Rocha, P. Mintz, et al. "Different use of T cell receptor transducing modules in two populations of gut intraepithelial lymphocytes are related to distinct pathways of T cell differentiation." Journal of Experimental Medicine 180, no. 2 (1994): 673–79. http://dx.doi.org/10.1084/jem.180.2.673.

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Most gut intraepithelial cells (IEL) of the mouse are T cells that bear CD8 molecules, present either as alpha-beta chain heterodimers (CD8 beta+) or as alpha chain homodimers (CD8 beta-). All CD8 beta+ IEL bear alpha/beta T cell receptors (TCR); CD8 beta- IEL bear either alpha/beta or gamma/delta TCR and are considered to be a thymus-independent (TI) population, probably arising locally from a small fraction of CD3- IEL containing the recombinant activating gene RAG proteins. Here we report that TI CD8 beta- IEL, whether bearing alpha/beta or gamma/delta TCR, contain, in normal mice, mRNAs fo

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18

Gorbatova, Irina V., Elizaveta A. Kazakova, Mikhail S. Podlutskii, et al. "Studying Gene Expression in Irradiated Barley Cultivars: PM19L-like and CML31-like Expression as Possible Determinants of Radiation Hormesis Effect." Agronomy 10, no. 11 (2020): 1837. http://dx.doi.org/10.3390/agronomy10111837.

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Gamma (γ)-irradiation of plants at low doses can provoke a broad range of growth-stimulating effects. In order to reveal universal target genes that are involved in molecular pathways of radiation hormesis establishment, we studied nine barley cultivars for their tolerance to γ-irradiation of seeds. Four morphological traits were assessed in barley seedlings after γ-irradiation of seeds at 20 Gy. Nine cultivars were sorted according to the sensitivity to irradiation as γ-stimulated, “no morphological effect”, or γ-inhibited. Gene expression of 17 candidate genes was evaluated for the 7 most co

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19

Shirakawa, F., Y. Tanaka, S. Eto, H. Suzuki, J. Yodoi, and U. Yamashita. "Effect of interleukin 1 on the expression of interleukin 2 receptor (Tac antigen) on human natural killer cells and natural killer-like cell line (YT cells)." Journal of Immunology 137, no. 2 (1986): 551–56. http://dx.doi.org/10.4049/jimmunol.137.2.551.

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Abstract The effect of interleukin 1 (IL 1) on the expression of interleukin 2 receptor (IL 2R/Tac antigen) on human natural killer (NK) cells and the NK-like cell line, YT was studied with the use of a fluoresceinated anti-IL 2R monoclonal antibody and a Spectrum III flow cytofluorometer. IL 2R was expressed on approximately 10% of NK cells. The expression of IL 2R on NK cells was increased to approximately 25% by the in vitro culture with monocytes or IL 1 and to a less extent by the culture with IL 2 or interferon-gamma (IFN-gamma). IL 2R was expressed on approximately 50% of YT cells witho

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20

Tasnim, Israt, Nuri Ince, Sujit Prabhu, et al. "NIMG-64. INTRAOPERATIVE LANGUAGE MAPPING USING GAMMA-BAND MODULATIONS OF ELECTROCORTICOGRAM (ECOG) INDUCED BY WORD/SOUND CATEGORIZATION TASK: VALIDATION WITH REPRODUCIBLE SPEECH ARRESTS DURING LINGUISTIC TASKS." Neuro-Oncology 24, Supplement_7 (2022): vii178—vii179. http://dx.doi.org/10.1093/neuonc/noac209.682.

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Abstract OBJECTIVE Determination of the correlation between gamma-band modulations of electrocorticogram (ECoG) induced by linguistic tasks and reproducible speech arrests caused by bipolar direct cortical stimulations (DCS). METHODS 3 subjects (age 39, 56, 64 years) with left temporal lobe glioma underwent surgery involving awake craniotomy. A 4x8 ECoG electrode grid (2.3mm contact exposure, 1cm contact spacing) was placed above the respective tumor area. A MATLAB-Simulink based real-time software system running on a portable laptop computer was used to map gamma-band modulations as a 2D heat

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Croft, M., and S. L. Swain. "Recently activated naive CD4 T cells can help resting B cells, and can produce sufficient autocrine IL-4 to drive differentiation to secretion of T helper 2-type cytokines." Journal of Immunology 154, no. 9 (1995): 4269–82. http://dx.doi.org/10.4049/jimmunol.154.9.4269.

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Abstract Development of T cells during primary responses was investigated using pigeon cytochrome C-specific naive Th from TCR transgenic mice. Naive CD4 cells did not activate and help resting B cells. This failure was found to be primarily because the resting B cells were incapable of stimulating the naive Th. Provision of a costimulatory signal such as anti-CD28, or addition of APCs that express costimulatory molecules, such as dendritic cells, activated B cells, and B7+ and B7+ICAM(+)-expressing fibroblasts, induced naive Th activation and promoted T cell-dependent help for IgM secretion.

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22

Palmer, E. M., and G. A. van Seventer. "Human T helper cell differentiation is regulated by the combined action of cytokines and accessory cell-dependent costimulatory signals." Journal of Immunology 158, no. 6 (1997): 2654–62. http://dx.doi.org/10.4049/jimmunol.158.6.2654.

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Abstract We have developed an in vitro differentiation model for human Th cells to study the role of cytokines and accessory cell-dependent costimulatory signals in this process. Peripheral blood-derived CD4+ "naive" (CD45RA+ RO-) T cells were stimulated in weekly intervals with immobilized anti-CD3 mAb, accessory cells, and exogenous cytokines, and were analyzed for cytokine secretion pattern. With the B cell line JY (B7-1+ B7-2+), as source of accessory cells, we could generate distinct Th subsets. Coculture with the combination of recombinant human (rh) IL-1beta and rhIL-6 gave rise to Th0-

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23

Cheron, Julian, and Guy Cheron. "Beta-gamma burst stimulations of the inferior olive induce high-frequency oscillations in the deep cerebellar nuclei." European Journal of Neuroscience 48, no. 8 (2018): 2879–89. http://dx.doi.org/10.1111/ejn.13873.

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Poccia, F., S. Boullier, H. Lecoeur, et al. "Peripheral V gamma 9/V delta 2 T cell deletion and anergy to nonpeptidic mycobacterial antigens in asymptomatic HIV-1-infected persons." Journal of Immunology 157, no. 1 (1996): 449–61. http://dx.doi.org/10.4049/jimmunol.157.1.449.

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Abstract Gamma delta T cells represent a minor population of human peripheral lymphocytes, the majority of them expressing the V delta 2/V gamma 9 TCR. Their accumulation in infectious disease lesions and their reactivity toward mycobacterial Ags suggest that V gamma 9/V delta 2 T cells play a role during infectious diseases. We have shown previously a significant expansion of the V delta 1 subset parallel to a dramatic decrease of the V delta 2 subset in PBMC from HIV-infected persons. To understand the mechanisms involved in the deletion of V delta 2 T cells, we analyzed their ability to res

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Kim, Woo Sik, DaeSeong Choi, Ji Min Park, et al. "Comparison of Exosomes Derived from Non- and Gamma-Irradiated Melanoma Cancer Cells as a Potential Antigenic and Immunogenic Source for Dendritic Cell-Based Immunotherapeutic Vaccine." Vaccines 8, no. 4 (2020): 699. http://dx.doi.org/10.3390/vaccines8040699.

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Cancer cells can secrete exosomes under various stressful conditions, whose functions are involved in the delivery of various biologically active materials into host cells and/or modulation of host immune responses. Therefore, an improved understanding of the immunological interventions that stress-induced tumor exosomes have may provide novel therapeutic approaches and more effective vaccine designs. Here, we confirmed the phenotypical and functional alterations of dendritic cells (DCs), which act as a bridge between the innate and adaptive arms of immunity, following non-irradiated (N-exo) a

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Claro, E., A. Garcia, and F. Picatoste. "Carbachol and histamine stimulation of guanine-nucleotide-dependent phosphoinositide hydrolysis in rat brain cortical membranes." Biochemical Journal 261, no. 1 (1989): 29–35. http://dx.doi.org/10.1042/bj2610029.

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Guanine nucleotides have been shown to stimulate phosphoinositide breakdown in brain membranes, but no potentiation of such an effect by agonist was demonstrated. We have studied the effect of carbachol and histamine on guanosine 5′-[gamma-thio]triphosphate (GTP[S]) stimulation of inositol phosphates formation in [3H]inositol-labelled rat brain cortical membranes. In this preparation, GTP[S] enhancement of phosphoinositide hydrolysis required the presence of MgATP and low Ca2+ concentration (100 nM). Carbachol potentiation of the GTP[S] effect was only observed when 1 mM-deoxycholate was also

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27

Thörn, Carolina Wilnerzon, Vasilios Kafetzopoulos, and Bernat Kocsis. "Differential Effect of Dopamine D4 Receptor Activation on Low-Frequency Oscillations in the Prefrontal Cortex and Hippocampus May Bias the Bidirectional Prefrontal–Hippocampal Coupling." International Journal of Molecular Sciences 23, no. 19 (2022): 11705. http://dx.doi.org/10.3390/ijms231911705.

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Dopamine D4 receptor (D4R) mechanisms are implicated in psychiatric diseases characterized by cognitive deficits, including schizophrenia, ADHD, and autism. The cellular mechanisms are poorly understood, but impaired neuronal synchronization in cortical networks was proposed to contribute to these deficits. In animal experiments, D4R activation was shown to generate aberrant increased gamma oscillations and to reduce performance on cognitive tasks requiring functional prefrontal cortex (PFC) and hippocampus (HPC) networks. While fast oscillations in the gamma range are important for local sync

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Schumacher, Peter M., Jan Dossche, Eric P. Mortier, Martin Luginbuehl, Thomas W. Bouillon, and Michel M. R. F. Struys. "Response Surface Modeling of the Interaction between Propofol and Sevoflurane." Anesthesiology 111, no. 4 (2009): 790–804. http://dx.doi.org/10.1097/aln.0b013e3181b799ef.

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Background Propofol and sevoflurane display additivity for gamma-aminobutyric acid receptor activation, loss of consciousness, and tolerance of skin incision. Information about their interaction regarding electroencephalographic suppression is unavailable. This study examined this interaction as well as the interaction on the probability of tolerance of shake and shout and three noxious stimulations by using a response surface methodology. Methods Sixty patients preoperatively received different combined concentrations of propofol (0-12 microg/ml) and sevoflurane (0-3.5 vol.%) according to a c

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Kim, Jieun, Ju Hwan Yang, In Soo Ryu, Sumin Sohn, Sunghyun Kim, and Eun Sang Choe. "Interactions of Glutamatergic Neurotransmission and Brain-Derived Neurotrophic Factor in the Regulation of Behaviors after Nicotine Administration." International Journal of Molecular Sciences 20, no. 12 (2019): 2943. http://dx.doi.org/10.3390/ijms20122943.

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Nicotine causes tobacco dependence, which may result in fatal respiratory diseases. The striatum is a key structure of forebrain basal nuclei associated with nicotine dependence. In the striatum, glutamate release is increased when α7 nicotinic acetylcholine receptors expressed in the glutamatergic terminals are exposed to nicotine, and over-stimulates glutamate receptors in gamma amino-butyric acid (GABA)ergic neurons. These receptor over-stimulations in turn potentiate GABAergic outputs to forebrain basal nuclei and contribute to the increase in psychomotor behaviors associated with nicotine

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Bewket, Gezahegn, Amare Kiflie, Fitsumbrhan Tajebe, Ebba Abate, Thomas Schön, and Robert Blomgran. "Helminth species dependent effects on Th1 and Th17 cytokines in active tuberculosis patients and healthy community controls." PLOS Neglected Tropical Diseases 16, no. 8 (2022): e0010721. http://dx.doi.org/10.1371/journal.pntd.0010721.

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Despite that the impact of different helminth species is not well explored, the current dogma states that helminths affect the Th1/Th2 balance which in turn affects the risk of tuberculosis (TB) reactivation and severity of disease. We investigated the influence of helminth species on cytokine profiles including IL-17A in TB patients and healthy community controls (CCs). In total, 104 newly diagnosed pulmonary TB patients and 70 HIV negative and QuantiFERON negative CCs in Gondar, Ethiopia were included following helminth screening by stool microscopy. Plasma samples and ex vivo stimulation of

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Butterfield, Lisa, and Hadas Naveh. "Adenovirus vector-specific cellular immunity induced by engineered human dendritic cells in vitro and in vivo (P4434)." Journal of Immunology 190, no. 1_Supplement (2013): 126.3. http://dx.doi.org/10.4049/jimmunol.190.supp.126.3.

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Abstract Recombinant adenovirus has been used in gene transfer applications, including cancer immunotherapy and infectious disease. Immunity to the adenoviral vector is known to include a potent humoral response; however, the cellular response is poorly characterized. Here, we evaluated the virus-specific response to an AdV encoding three melanoma tumor antigens (Tyrosinase, MART-1 and MAGE-A6 (AdVTMM2)) in healthy donors and patients with melanoma. CD4+ and CD8+ T cell responses were followed weekly by multi-cytokine ELISPOT assays (IFN-gamma, IL-2, IL-10 and TNF) and flow cytometric analysis

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Flamand, V., D. Abramowicz, M. Goldman, et al. "Anti-CD3 antibodies induce T cells from unprimed animals to secrete IL-4 both in vitro and in vivo." Journal of Immunology 144, no. 8 (1990): 2875–82. http://dx.doi.org/10.4049/jimmunol.144.8.2875.

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Abstract Recently, functional heterogeneity among Th cells has been recognized. Based on pattern of lymphokine secretion, two mutually exclusive subsets of CD4+ cells have been defined and designated Th1 (secreting IL-2 and IFN-gamma) and Th2 (secreting IL-4 and IL-5). Identification of these subsets was mostly based on the study of long term cultured T cell lines and clones, and little is known about the Th heterogeneity in vivo. In particular, it has been suggested that IL-4 producing cells cannot be detected in vivo or in primary stimulations in vitro unless responder cells had been previou

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Bonfiglio, Tommaso, Matteo Vergassola, Guendalina Olivero, and Anna Pittaluga. "Environmental Training and Synaptic Functions in Young and Old Brain: A Presynaptic Perspective." Current Medicinal Chemistry 26, no. 20 (2019): 3670–84. http://dx.doi.org/10.2174/0929867325666180228170450.

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Background:Aging is an unavoidable, physiological process that reduces the complexity and the plasticity of the synaptic contacts in Central Nervous System (CNS), having profound implications for human well-being. The term “cognitive reserve” refers to central cellular adaptations that augment the resilience of human brain to damage and aging. The term “Cognitive training” indicates the cultural, social and physical stimulations proposed as add-on therapy for the cure of central neurological diseases. “Cognitive training” reinforces the “cognitive reserve” permitting to counteract brain impair

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Lucas, Kenneth G., Qi Sun, Nargisa Niyazova-Brewer, and Lei Bao. "Rapid Generation of Cytomegalovirus Specific T Lymphocytes Using Commercially Available CMV pp65 Peptides." Blood 108, no. 11 (2006): 5144. http://dx.doi.org/10.1182/blood.v108.11.5144.5144.

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Abstract Adoptive immunotherapy with cytomegalovirus (CMV) specific cytotoxic T lymphocytes (CTL) can result in resolution of viremia and reconstiution of CMV specific immunity following allogeneic stem cell transplantation. Most recipients of allogeneic transplants who develop CMV reactivation are successfully treated with anti-viral agents, however some have persistent viremia or develop CMV disease despite these medications. In these situations the development of CMV specific T cells may be impractical due to time contraints or institutional limitations. We have expanded CMV pp65 specific C

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35

Dwivedi, Alka, Lynn Fu, Chris Daniel Chien, Marie Pouzolles, Nirali N. Shah, and Naomi Taylor. "Engineering Off-the-Shelf Gamma Delta CAR T Cells for the Treatment of Acute Myeloid Leukemia." Blood 142, Supplement 1 (2023): 4827. http://dx.doi.org/10.1182/blood-2023-190357.

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Chimeric antigen receptor T cell therapy (CART) therapy has shown remarkable success in the treatment of B cell acute lymphoblastic leukemias (B-ALL) and lymphomas. However, CART therapies for acute myeloid leukemia (AML), where 5-year survival rates are significantly lower than for B-ALL, are only in their infancy. CD33-CART have potent activity against AML in preclinical models and a first-in-child/first-in-human phase 1/2 CD33-CART clinical trial for AML is ongoing in the Pediatric Oncology Branch of the National Cancer Institute (NCT03971799). Nonetheless, published outcomes suggest a mode

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36

Ko, Li-Wei, Rupesh Kumar Chikara, Po-Yin Chen, et al. "Noisy Galvanic Vestibular Stimulation (Stochastic Resonance) Changes Electroencephalography Activities and Postural Control in Patients with Bilateral Vestibular Hypofunction." Brain Sciences 10, no. 10 (2020): 740. http://dx.doi.org/10.3390/brainsci10100740.

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Patients with bilateral vestibular hypofunction (BVH) often suffer from imbalance, gait problems, and oscillopsia. Noisy galvanic vestibular stimulation (GVS), a technique that non-invasively stimulates the vestibular afferents, has been shown to enhance postural and walking stability. However, no study has investigated how it affects stability and neural activities while standing and walking with a 2 Hz head yaw turning. Herein, we investigated this issue by comparing differences in neural activities during standing and walking with a 2 Hz head turning, before and after noisy GVS. We applied

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Bergmann, Liane, Matthias Staudinger, Christiane Pott, et al. "Potent Activation of Healthy Donor T-Cells Specific for Mantle Cell Lymphoma Immunoglobulin Derived Peptides by CD40- and TLR7/8-Ligand Matured Dendritic Cells in Vitro." Blood 112, no. 11 (2008): 3502. http://dx.doi.org/10.1182/blood.v112.11.3502.3502.

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Abstract Patients with mantle cell lymphoma (MCL) and MRD after intensive radiochemotherapy and autologous stem cell transplantation have a high risk of relapse. Allogeneic stem cell transplantation offers the possibility of cure but is associated with a high risk of severe “graft versus host disease”(GvHD). A way to decrease the risk of GvHD while augmenting the “graft versus lymphoma” effect may be the in vitro activation and subsequent transplantation of allogeneic idiotyp-specific T-cells. This study was set out to determine whether cytotoxic T-cell responses specific for peptides derived

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38

Weinberg, JB, MA Misukonis, PJ Shami, et al. "Human mononuclear phagocyte inducible nitric oxide synthase (iNOS): analysis of iNOS mRNA, iNOS protein, biopterin, and nitric oxide production by blood monocytes and peritoneal macrophages." Blood 86, no. 3 (1995): 1184–95. http://dx.doi.org/10.1182/blood.v86.3.1184.1184.

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Abstract Nitric oxide (NO) is produced by numerous different cell types, and it is an important regulator and mediator of many processes including smooth muscle relaxation, neurotransmission, and murine macrophage- mediated cytotoxicity for microbes and tumor cells. Although murine macrophages produce NO readily after activation, human monocytes and tissue macrophages have been reported to produce only low levels of NO in vitro. The purpose of this study was to determine if stimulated human mononuclear phagocytes produce inducible nitric oxide synthase (iNOS) mRNA, protein, and enzymatic activ

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Weinberg, JB, MA Misukonis, PJ Shami, et al. "Human mononuclear phagocyte inducible nitric oxide synthase (iNOS): analysis of iNOS mRNA, iNOS protein, biopterin, and nitric oxide production by blood monocytes and peritoneal macrophages." Blood 86, no. 3 (1995): 1184–95. http://dx.doi.org/10.1182/blood.v86.3.1184.bloodjournal8631184.

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Nitric oxide (NO) is produced by numerous different cell types, and it is an important regulator and mediator of many processes including smooth muscle relaxation, neurotransmission, and murine macrophage- mediated cytotoxicity for microbes and tumor cells. Although murine macrophages produce NO readily after activation, human monocytes and tissue macrophages have been reported to produce only low levels of NO in vitro. The purpose of this study was to determine if stimulated human mononuclear phagocytes produce inducible nitric oxide synthase (iNOS) mRNA, protein, and enzymatic activity. By r

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40

Wang, Dingyan, A. Keith Stewart, Lihua Zhuang, et al. "Genetic Disruption of the SH3 and SAM Domains of HACS1 Enhances Adaptive Immunity." Blood 110, no. 11 (2007): 2299. http://dx.doi.org/10.1182/blood.v110.11.2299.2299.

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Abstract HACS1 is a SH3 (Src homology 3) and SAM (sterile alpha motif) domain containing adaptor protein that is expressed in activated B and dendritic cells, is up-regulated by Interleukin 4 in the process of B cell activation and likely serves to dampen the immune response. To elucidate the function of HACS1, we generated HACS1 gene knockout mice by deletion of the SH3 and SAM domains. HACS1−/− mice were viable and fertile and had normal bone marrow B cell development and normal splenic T and B cell populations. However, adult HACS1−/− mice had increased numbers of peritoneal B1 cells (IgM+C

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41

Distler, Eva, Catherine Woelfel, Sylvia Pesth, et al. "Rapid Expansion of Acute Myeloid Leukemia-Reactive Cytotoxic T Cells from CD8+CD62L+ Blood Lymphocytes of HLA-Matched Healthy Donors In Vitro." Blood 108, no. 11 (2006): 3238. http://dx.doi.org/10.1182/blood.v108.11.3238.3238.

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Abstract Allogeneic cytotoxic T-lymphocyte (CTL) therapy in acute myeloid leukemia (AML) is hampered by the poor efficiency of growing leukemia-reactive CTLs from healthy donors in vitro. We established an allogeneic mini-mixed lymphocyte-leukemia culture (MLLC) approach by stimulating comparably small numbers (104/well) of CD8+ T cells isolated from healthy donors against irradiated primary AML blasts in 96-well plates. Prior to use, CD8+ T cells were immunomagnetically separated into a CD62L(high)+ subset enriched for naive precursors and central memory cells as well as a CD62L(low)+/negativ

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42

Hunt, Lee, Scott Hadley, Scott Reynolds, Regan Gilbert, Jon Rule, and Michael Kinzikeev. "Precise 3D seismic steering and production rates in the Wilrich tight gas sands of West Central Alberta." Interpretation 2, no. 2 (2014): SC1—SC18. http://dx.doi.org/10.1190/int-2013-0086.1.

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We evaluate the controls on production performance of the Wilrich tight gas sand play in West Central Alberta, and show that careful steering using 3D seismic to place the wellbore within the upper reservoir is the most important geophysical contribution to production outcomes. Geologic, geophysical, drilling, and production data from more than 20 wells are used in the analysis. The completion and production parameters within the study area are relatively invariant, creating a control experiment relative to other productivity factors. We thus isolate the effects of varying bottom hole pressure

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43

Zhang, Cenrong, Yuemin Wang, Meng Wang, et al. "Rapeseed Oil and Ginseng Saponins Work Synergistically To Enhance Th1 and Th2 Immune Responses Induced by the Foot-and-Mouth Disease Vaccine." Clinical and Vaccine Immunology 21, no. 8 (2014): 1113–19. http://dx.doi.org/10.1128/cvi.00127-14.

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ABSTRACTPrevious investigations demonstrated that saponins isolated from the root ofPanax ginsengC. A. Meyer (i.e., ginseng root saponin [GS-R]) had adjuvant activity. In the present study, the combined effects of rapeseed oil (RO) and GS-R on the immune responses elicited by foot-and-mouth disease (FMD) vaccine were investigated by measuring FMD virus (FMDV)-specific antibody levels, cytokine levels, lymphocyte proliferation, and long-lived IgG-secreting plasma cells from bone marrow in a mouse model. The results indicated that RO in combination with GS-R significantly enhanced serum IgG and

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44

Bacchetta, R., R. de Waal Malefijt, H. Yssel, et al. "Host-reactive CD4+ and CD8+ T cell clones isolated from a human chimera produce IL-5, IL-2, IFN-gamma and granulocyte/macrophage-colony-stimulating factor but not IL-4." Journal of Immunology 144, no. 3 (1990): 902–8. http://dx.doi.org/10.4049/jimmunol.144.3.902.

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Abstract In the present study, we investigated the lymphokine production patterns in a series of CD4+ and CD8+ host-reactive T cell clones isolated from PBL of a SCID patient, who was immunologically reconstituted by two allogeneic fetal liver and thymus transplantations 13 years ago. We demonstrate that these donor-derived T cell clones, specifically reacting with the MHC Ag expressed on the recipient cells, do not produce IL-4 and do not express IL-4 mRNA upon Ag or polyclonal stimulations. In contrast, CD4+ tetanus toxin-specific T cell clones isolated from the same patient and having the s

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45

Barber, K. E., P. S. Crosier, and J. D. Watson. "The differential inhibition of hemopoietic growth factor activity by cytotoxins and interferon-gamma." Journal of Immunology 139, no. 4 (1987): 1108–12. http://dx.doi.org/10.4049/jimmunol.139.4.1108.

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Abstract The effects of recombinant human tumor necrosis factor (TNF), lymphotoxin (LT), and interferon-gamma (IFN-gamma) on the growth of human hemopoietic progenitor cells in clonal culture have been examined. Colony growth was induced by using granulocyte colony-stimulating factor (G-CSF), or granulocyte-macrophage colony-stimulating factor (GM-CSF). A suppressive effect of TNF, LT, and IFN-gamma on the development of granulocyte, macrophage, and mixed granulocyte/macrophage colonies was shown. Suppression of colonies formed after stimulation with G-CSF was greater than that observed after

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46

Udompornpitak, Kanyarat, Thansita Bhunyakarnjanarat, Awirut Charoensappakit, Cong Phi Dang, Wilasinee Saisorn, and Asada Leelahavanichkul. "Lipopolysaccharide-Enhanced Responses against Aryl Hydrocarbon Receptor in FcgRIIb-Deficient Macrophages, a Profound Impact of an Environmental Toxin on a Lupus-Like Mouse Model." International Journal of Molecular Sciences 22, no. 8 (2021): 4199. http://dx.doi.org/10.3390/ijms22084199.

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Fc gamma receptor IIb (FcgRIIb) is the only inhibitory-FcgR in the FcgR family, and FcgRIIb-deficient (FcgRIIb−/−) mice develop a lupus-like condition with hyper-responsiveness against several stimulations. The activation of aryl hydrocarbon receptor (Ahr), a cellular environmental sensor, might aggravate activity of the lupus-like condition. As such, 1,4-chrysenequinone (1,4-CQ), an Ahr-activator, alone did not induce supernatant cytokines from macrophages, while the 24 h pre-treatment by lipopolysaccharide (LPS), a representative inflammatory activator, prior to 1,4-CQ activation (LPS/1,4-CQ

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47

Cheever, A. W., M. E. Williams, T. A. Wynn, et al. "Anti-IL-4 treatment of Schistosoma mansoni-infected mice inhibits development of T cells and non-B, non-T cells expressing Th2 cytokines while decreasing egg-induced hepatic fibrosis." Journal of Immunology 153, no. 2 (1994): 753–59. http://dx.doi.org/10.4049/jimmunol.153.2.753.

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Abstract Increasing evidence suggests that schistosome egg granulomas are primarily Th2 cellular reactions. Mice infected with Schistosoma mansoni were treated with a neutralizing mAb against IL-4 to evaluate the role of this cytokine in the generation of parasite egg-induced cell-mediated responses and hepatic pathology. Animals treated with anti-IL-4 before egg deposition showed decreased IL-4, IL-5, and IL-10 production in response to in vitro antigenic stimulations and decreased IL-5 and IL-13 mRNA levels in the liver. As observed previously, non-B, non-T cells were a major source of IL-4

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48

Novelli, F., M. M. D'Elios, P. Bernabei, et al. "Expression and role in apoptosis of the alpha- and beta-chains of the IFN-gamma receptor on human Th1 and Th2 clones." Journal of Immunology 159, no. 1 (1997): 206–13. http://dx.doi.org/10.4049/jimmunol.159.1.206.

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Abstract The mRNA and protein expression of the alpha- and beta-chains of IFN-gammaR were evaluated on a panel of human Th1 and Th2 clones. When cultured in IL-2-conditioned medium, both types of clones expressed mRNA for the alpha- and beta-chains, and both chains were present in the cytoplasm. Membrane expression of the alpha-chain was higher on Th2 than on Th1, whereas the beta-chain was poorly expressed on both types but increased following IL-2 withdrawal or PHA stimulation. In addition, both types of clones overexpressed MHC class I glycoproteins following IFN-gammaR triggering by exogen

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Leclercq, G., and J. Plum. "Stimulation of TCR V gamma 3 cells by gram-negative bacteria." Journal of Immunology 154, no. 10 (1995): 5313–19. http://dx.doi.org/10.4049/jimmunol.154.10.5313.

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Abstract A distinct feature of most murine TCR-gamma delta cells is that they localize in epithelial tissues that cover the internal and external surface of the body. Therefore, TCR-gamma delta cells have been hypothesized to represent a first line of defense against invading pathogens. In this study, it is shown that TCR V gamma 3 cells are activated to produce cytokines upon interaction with Gram-negative bacteria, whereas Gram-positive bacteria have no effect. Accessory cells are not required. LPS of Gram-negative bacteria is shown to be the stimulating structure for TCR V gamma 3 cells, as

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50

Piacibello, W., L. Lu, D. Williams, et al. "Human gamma interferon enhances release from phytohemagglutinin- stimulated T4+ lymphocytes of activities that stimulate colony formation by granulocyte-macrophage, erythroid, and multipotential progenitor cells." Blood 68, no. 6 (1986): 1339–47. http://dx.doi.org/10.1182/blood.v68.6.1339.1339.

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Abstract Human gamma interferon (HuIFN gamma) was evaluated for its effects on the release from human peripheral blood T lymphocytes (greater than 98% pure) stimulated by phytohemagglutinin (PHA) of activities that can stimulate granulocyte-macrophage (CFU-GM) colonies and clusters, erythroid (BFU-E) bursts, and mixed (CFU-GEMM) colonies. T lymphocytes did not release these activities in the absence of PHA with or without HuIFN gamma. In the presence of PHA, pure natural HuIFN gamma at concentrations of 0.1 to 100 U/mL significantly enhanced release of these colony-stimulating activities. Alth

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