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Artículos de revistas sobre el tema "Gastric mucosa Effect of drugs on"

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Publicado: 4 de junio de 2021
Última modificación: 29 de enero de 2023

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1

Lavy, Alexandra. "Corrosive Effect of Nifedipine in the Upper Gastrointestinal Tract." Diagnostic and Therapeutic Endoscopy 6, no. 1 (January 1, 1999): 39–41. http://dx.doi.org/10.1155/dte.6.39.

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Upper gastrointestinal tract mucosa is prone to injury. Drugs may disturb gastric mucosa protective mechanisms and cause damage. Injury by NSAIDs is a well described complication. Nifedipine, a widely used drug, was not described before as having a potential to damage gastrointestinal mucosa. We describe here, two patients, who developed esophageal and gastric mucosal damage, probably related to Nifedipine ingestion.
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Lu, Sheng-Yu, Song Guo, Shao-Bin Chai, Jia-Qi Yang, Yuan Yue, Hao Li, Pei-Ming Sun, et al. "Autophagy in Gastric Mucosa: The Dual Role and Potential Therapeutic Target." BioMed Research International 2021 (June 11, 2021): 1–8. http://dx.doi.org/10.1155/2021/2648065.

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The incidence of stomach diseases is very high, which has a significant impact on human health. Damaged gastric mucosa is more vulnerable to injury, leading to bleeding and perforation, which eventually aggravates the primary disease. Therefore, the protection of gastric mucosa is crucial. However, existing drugs that protect gastric mucosa can cause nonnegligible side effects, such as hepatic inflammation, nephritis, hypoacidity, impotence, osteoporotic bone fracture, and hypergastrinemia. Autophagy, as a major intracellular lysosome-dependent degradation process, plays a key role in maintain
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3

Andrews, F. J., C. Malcontenti-Wilson, and P. E. O'Brien. "Effect of nonsteroidal anti-inflammatory drugs on LFA-1 and ICAM-1 expression in gastric mucosa." American Journal of Physiology-Gastrointestinal and Liver Physiology 266, no. 4 (April 1, 1994): G657—G664. http://dx.doi.org/10.1152/ajpgi.1994.266.4.g657.

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Leukocyte adhesion to the endothelium appears to play an important role in gastric injury. This study aimed to develop immunohistochemical staining techniques to investigate the distribution and sequence of expression of both leukocyte [lymphocyte function associated antigen 1 (LFA-1)] and endothelial [intracellular adhesion molecule 1 (ICAM-1)] adhesion molecules in the mucosa after treatment with nonsteroidal anti-inflammatory drugs (NSAIDs). In control rats there were 803 +/- 72 LFA-1-stained cells/mm2 in the deep mucosa, 134 +/- 32 cells/mm2 in the superficial mucosa, and 6.4 +/- 1.2 ICAM-
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4

Fang, Yan Fei, Wen Li Xu, Lan Wang, Qing Wu Lian, Li Feng Qiu, Hui Zhou, and Shu Jie Chen. "Effect of Hydrotalcite on Indometacin-Induced Gastric Injury in Rats." BioMed Research International 2019 (April 11, 2019): 1–9. http://dx.doi.org/10.1155/2019/4605748.

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Background and Aims. Hydrotalcite plays an important role in the therapy of gastric ulcer induced by nonsteroidal anti-inflammatory drugs (NSAIDs), but little is known about the mechanism. We designed two experiments to study the preventive and curative effects of hydrotalcite on NSAIDs-related gastric injury in rats and to investigate the relationship between the protective and curative mechanism of hydrotalcite and the secretion of epidermal growth factor (EGF)/prostaglandin E2 (PGE2). Methods. Two experiments were separately designed to evaluate the preventive and curative effects of hydrot
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5

Ren, Shou-zhong, Jian-sheng Guo, Lin Sheng, Chen Jun, Shui-ping Dai, and Zhi-jian Ma. "PROTECTIVE EFFECT OF FENGLIAO-CHANGWEIKANG EXTRACTS, A TRADITIONAL CHINESE HERBAL MEDICINE FORMULA,ON MUCOSA IN RAT WITH CHRONIC GASTRITIS." African Journal of Traditional, Complementary and Alternative Medicines 13, no. 1 (December 3, 2015): 53–61. http://dx.doi.org/10.21010/ajtcam.v13i1.8.

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Background: Fengliao-Changwei-Kang(FCK), Chinese patent drug, is a famous traditional Chinese herbal medicine formula, which is effectively used to cure gastrointestinal disease including gastritis, enteritis and diarrhea in the clinic for many years. However, little research has been focused on the protective effects of FCK on the gastric mucosa of chronic gastritis (CG) model rat.
 Objective: The present study aimed to explore the effects of FCK extract on mucosa in rats with Chronic Gastritis.
 Materials and Methods: The CG rat model was induced by synthetic methods. The serum lev
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6

Villa, Afonso Luiz, Ceneviva Reginaldo, Fernanda Viaro, Fernando Ramalho, Antonio Dorival Campos, and Paulo Roberto B. Evora. "The cytoprotective effect of a nitric oxide donor drug on gastric mucous membrane of rats treated with ketoprofen, a non-steroidal anti-inflammatory drug." Arquivos de Gastroenterologia 43, no. 3 (September 2006): 233–37. http://dx.doi.org/10.1590/s0004-28032006000300015.

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BACKGROUND: Non-steroidal anti-inflammatory drugs are considered today a very important group of medication, with a wide variety of therapeutic use, in different areas of modern medicine. Despite their beneficial effects on the patient, these drugs show a high incidence of side effects, mainly in the gastrointestinal tract. The physiopathological mechanisms of non-steroidal anti-inflammatory drugs induced lesions and the gastric mucosa defense mechanism became an important source for medical research, especially those which try to evaluate the role of nitric oxide as a cytoprotective agent. AI
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7

Bakalarz, Dominik, Edyta Korbut, Zhengnan Yuan, Bingchen Yu, Dagmara Wójcik, Aleksandra Danielak, Katarzyna Magierowska, et al. "Novel Hydrogen Sulfide (H2S)-Releasing BW-HS-101 and Its Non-H2S Releasing Derivative in Modulation of Microscopic and Molecular Parameters of Gastric Mucosal Barrier." International Journal of Molecular Sciences 22, no. 10 (May 14, 2021): 5211. http://dx.doi.org/10.3390/ijms22105211.

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Hydrogen sulfide (H2S) is an endogenously produced molecule with anti-inflammatory and cytoprotective properties. We aimed to investigate for the first time if a novel, esterase-sensitive H2S-prodrug, BW-HS-101 with the ability to release H2S in a controllable manner, prevents gastric mucosa against acetylsalicylic acid-induced gastropathy on microscopic and molecular levels. Wistar rats were pretreated intragastrically with vehicle, BW-HS-101 (0.5–50 μmol/kg) or its analogue without the ability to release H2S, BW-iHS-101 prior to ASA administration (125 mg/kg, intragastrically). BW-HS-101 was
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8

Lyra, Anna, Markku Saarinen, Heli Putaala, Kaisa Olli, Sampo J. Lahtinen, Arthur C. Ouwehand, Mari Madetoja, and Kirsti Tiihonen. "Bifidobacterium animalisssp.lactis420 Protects against Indomethacin-Induced Gastric Permeability in Rats." Gastroenterology Research and Practice 2012 (2012): 1–9. http://dx.doi.org/10.1155/2012/615051.

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Gastrointestinal (GI) adverse effects such as erosion and increased permeability are common during the use of nonsteroidal anti-inflammatory drugs (NSAIDs). Our objective was to assess whetherBifidobacterium animalisssp.lactis420 protects against NSAID-induced GI side effects in a rat model. A total of 120 male Wistar rats were allocated into groups designated as control, NSAID, and probiotic. The NSAID and probiotic groups were challenged with indomethacin (10 mg/kg−1; single dose). The probiotic group was also supplemented daily with 1010 CFU ofB. lactis420 for seven days prior to the indome
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9

Bastaki, Salim MA, and John L. Wallace. "Pathogenesis of Nonsteroidal Anti-Inflammatory Drug Gastropathy: Clues to Preventative Therapy." Canadian Journal of Gastroenterology 13, no. 2 (1999): 123–27. http://dx.doi.org/10.1155/1999/738968.

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Gastric ulceration and bleeding are major impediments to the chronic use of nonsteroidal anti-inflammatory drugs (NSAIDs). The development of effective therapies for prevention of these adverse effects requires better understanding of their pathogenesis. Several features of NSAIDs contribute to the development of damage in the stomach, including the topical irritant effects of these drugs on the epithelium, impairment of the barrier properties of the mucosa, suppression of gastric prostaglandin synthesis, reduction of gastric mucosal blood flow and interference with the repair of superficial i
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10

Moghal, Naheed, and N. A. Jafarey. "Effects of Nonsteroidal Antiinflammatory Drugs on Gastric and Duodenal Mucosa." Gastroenterology 96, no. 2 (February 1989): 553–54. http://dx.doi.org/10.1016/0016-5085(89)91605-3.

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11

Kononenko, N. N., M. T. Mirzaliev, and V. V. Chikitkina. "The effect of dry extract of cabbage garden on the local non-specific proteinase-inhibitory potential of the mucous membrane of the stomach on the model of acute gastric ulcer." Farmatsevtychnyi zhurnal, no. 6 (December 21, 2019): 77–84. http://dx.doi.org/10.32352/10.32352/0367-3057.6.19.09.

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Peptic ulcer of the stomach and duodenum is a complex gastroenterological disease multifactorial in pathogenesis. One of the key components of non-specific inflammation in peptic ulcer disease is the activation of proteinases in the gastric mucosa and their interaction with proteinase inhibitors, which determines the degree of proteolytic aggression in terms of the development of destructive changes in the tissues that they damage.
 The aim of the work was to study the effect of dry extract of cabbage garden on the components of the proteinase-inhibitor system in experimental gastric ulce
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12

Parkhomenko, V. V., І. М. Skrypnyk, І. І. Starchenko, and O. F. Gopko. "CHARACTERISTICS OF GASTRIC MUCOSA INJURY IN PATIENTS WITH NSAID-INDUCED GASTROPATHY AND CONCOMITANT ISCHEMIC HEART DISEASE, AND WAYS TO CORRECT THIS CONDITION." Актуальні проблеми сучасної медицини: Вісник Української медичної стоматологічної академії 20, no. 2 (July 6, 2020): 70–75. http://dx.doi.org/10.31718/2077-1096.20.2.70.

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The non-steroidal anti-inflammatory drugs (NSAIDs) in general clinical practice can provoke the development of NSAID-induced gastropathy, which can be complicated by bleeding. The aim of this article was to evaluate the effect of eupatilin on histological changes of the gastric mucosa in patients with NSAID-induced gastropathy and concomitant ischemic heart disease depending on the association with Helicobacter pylori. The study included 125 patients with NSAID-gastropathy and concomitant stable ischemic heart disease I-II functional class. Patients were divided into two groups: I (n=82) inclu
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13

Kim, Sun-Joong, Young Sam Park, Hyun-Dong Paik, and Hyo Ihl Chang. "Effect of anthocyanins on expression of matrix metalloproteinase-2 in naproxen-induced gastric ulcers." British Journal of Nutrition 106, no. 12 (June 23, 2011): 1792–801. http://dx.doi.org/10.1017/s000711451100242x.

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Non-steroidal anti-inflammatory drugs cause gastric ulceration through a number of mechanisms including inhibition of PG synthesis, generation of reactive oxygen species (ROS) and induction of apoptosis. Recently, matrix metalloproteinases (MMP) have been suggested to play a crucial role in these mechanisms. The present study investigated the protective effect of anthocyanins isolated from black rice bran (Heugjinjubyeo) against naproxen-induced gastric mucosal injury in rats. The oral administration of anthocyanins (5, 25 or 50 mg/kg body weight) showed significant protection against naproxen
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14

Tijani, Stephanie Abiola, Samuel B. Olaleye, and Ebenezer O. Farombi. "Anti-ulcerogenic effect of the methanol extract of Chasmanthera dependens (Hochst) stem on male Wistar rats." Journal of Basic and Clinical Physiology and Pharmacology 29, no. 4 (July 26, 2018): 377–83. http://dx.doi.org/10.1515/jbcpp-2017-0152.

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AbstractBackgroundOxidative stress and free radical-mediated processes have been implicated in the pathogenesis of indomethacin-induced gastric ulcer. This study investigated the ability of the methanol extract ofChasmanthera dependensto protect the gastric mucosal from oxidative damage induced by oral administration of indomethacin in rats.MethodsTheC. dependensstems were chopped into pieces, air-dried, and pulverized into powder. One kilogram of the powder was macerated in 1 L of methanol for 72 h. The mixture was filtered and evaporated using rotatory evaporator to obtain the extract ofC. d
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15

Wang, Caihui, Wen Su, Xingli Su, Guojun Ni, Tao Liu, and Yi Kong. "Synergy Effects of Three Plant Extracts on Protection of Gastric Mucosa." Natural Product Communications 10, no. 11 (November 2015): 1934578X1501001. http://dx.doi.org/10.1177/1934578x1501001146.

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The gastric mucosa protection effect of three natural plant extracts, Hericium erinaceus (HE), Centella asiatica (CA) and Amomum villosum (AV), were evaluated using the indomethacin damage model. Compared with a single extract, a combination of HE/CA/AV, especially with the ratios of 80:10:10, 45:45:10 and 45:10:45, showed significant synergistic effects for protection of the gastric mucosa with gastric ulcer inhibition rates of 97.8 ± 0.7%, 86.5 ± 2.8% and 86.1 ± 3.6%, respectively. Microscopic appearances of the gastric mucosa were carried out to help confirm the results.
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16

Liu, Xiao-Yu, Li-Fei Zheng, Yan-Yan Fan, Qian-Ying Shen, Yao Qi, Guang-Wen Li, Qi Sun, Yue Zhang, Xiao-Yan Feng, and Jin-Xia Zhu. "Activation of dopamine D2 receptor promotes pepsinogen secretion by suppressing somatostatin release from the mouse gastric mucosa." American Journal of Physiology-Cell Physiology 322, no. 3 (March 1, 2022): C327—C337. http://dx.doi.org/10.1152/ajpcell.00385.2021.

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In vivo administration of dopamine (DA) receptor (DR)-related drugs modulate gastric pepsinogen secretion. However, DRs on gastric pepsinogen-secreting chief cells and DA D2 receptor (D2R) on somatostatin-secreting D cells were subsequently acquired. In this study, we aimed to further investigate the local effect of DA on gastric pepsinogen secretion through DRs expressed on chief cells or potential D2Rs expressed on D cells. To elucidate the modulation of DRs in gastric pepsinogen secretion, immunofluorescence staining, ex vivo incubation of gastric mucosa isolated from normal and D2R−/− mice
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17

Antonenko, Antonina V., and Tetyana V. Beregova. "The improvement of treatment efficacy of gastropathy associated with the use of nonsteroidal anti-inflammatory drugs in Helicobacter pylori-negative patients with osteoarthritis." Current Issues in Pharmacy and Medical Sciences 27, no. 4 (December 1, 2014): 237–39. http://dx.doi.org/10.1515/cipms-2015-0023.

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Abstract Among the more common side effects of osteoarthritis treatment are NSAID-gastropathy and NSAID-enteropathy. NSAIDs can cause direct injury to colon tissue and also impair synthesis of prostaglandins, reduce mucosal integrity, increase permeability and promote an influx of bacteria and toxins. Alterations in gastrointestinal permeability are considered as an initial step in the development of lesions of the gastric mucosa such as erosions and ulcers. The mechanisms underlying the ability of NSAIDs to cause ulceration in the stomach and proximal duodenum are well understood and this inj
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18

Fulga, Simona, Ana-Maria Pelin, Cristina Mihaela Ghiciuc, and Elena Cătălina Lupușoru. "Particularities of Experimental Models Used to Induce Gastric Ulcer." ARS Medica Tomitana 25, no. 4 (November 1, 2019): 179–84. http://dx.doi.org/10.2478/arsm-2019-0035.

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Abstract Introduction: Gastric ulcer is one of the most common gastrointestinal diseases, therefore the constant interest for new treatments is due to adverse effects induced by current therapy. The restricted number of in vivo experimental models is a challenge for researchers. Objectives: Identifying the particularities of different types of experimentally induced gastric ulcer in laboratory animals to facilitate their choise for the study of new antiulcer drugs. Material and method: A search in PubMed and Scopus using keywords ( “experimentally” AND “gastric ulcer” AND “rats/mice”) to inclu
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19

Mazumder, Somnath, Rudranil De, Subhashis Debsharma, Samik Bindu, Pallab Maity, Souvik Sarkar, Shubhra Jyoti Saha та ін. "Indomethacin impairs mitochondrial dynamics by activating the PKCζ–p38–DRP1 pathway and inducing apoptosis in gastric cancer and normal mucosal cells". Journal of Biological Chemistry 294, № 20 (2 квітня 2019): 8238–58. http://dx.doi.org/10.1074/jbc.ra118.004415.

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The subcellular mechanism by which nonsteroidal anti-inflammatory drugs (NSAIDs) induce apoptosis in gastric cancer and normal mucosal cells is elusive because of the diverse cyclooxygenase-independent effects of these drugs. Using human gastric carcinoma cells (AGSs) and a rat gastric injury model, here we report that the NSAID indomethacin activates the protein kinase Cζ (PKCζ)–p38 MAPK (p38)–dynamin-related protein 1 (DRP1) pathway and thereby disrupts the physiological balance of mitochondrial dynamics by promoting mitochondrial hyper-fission and dysfunction leading to apoptosis. Notably,
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20

Myszor, M. F., and H. J. F. Hodgson. "The Effect of Nonsteroidal Anti-Inflammatory Drugs on Dna Synthesis in Human Gastric Mucosa." Clinical Science 70, s13 (January 1, 1986): 39P. http://dx.doi.org/10.1042/cs070039pa.

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21

Morozova, Olga Yu. "Non-steroidal anti-inflammatory drugs: Deleterious effect on the gastric mucosa and protection against ulcerogenic effects." Integrative Physiology 2, no. 4 (2022): 390–98. http://dx.doi.org/10.33910/2687-1270-2021-2-4-390-398.

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22

Yu, Lanlan, Ruijun Li, Wei Liu, Yalin Zhou, Yong Li, Yong Qin, Yuhan Chen, and Yajun Xu. "Protective Effects of Wheat Peptides against Ethanol-Induced Gastric Mucosal Lesions in Rats: Vasodilation and Anti-Inflammation." Nutrients 12, no. 8 (August 7, 2020): 2355. http://dx.doi.org/10.3390/nu12082355.

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Alcohol consumption increases the risk of gastritis and gastric ulcer. Nutritional alternatives are considered for relieving the progression of gastric mucosal lesions instead of conventional drugs that produce side effects. This study was designed to evaluate the gastroprotective effects and investigate the defensive mechanisms of wheat peptides against ethanol-induced acute gastric mucosal injury in rats. Sixty male Sprague–Dawley rats were divided into six groups and orally treated with wheat peptides (0.1, 0.2, 0.4 g/kgbw) and omeprazole (20 mg/kgbw) for 4 weeks, following absolute ethanol
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23

THONGSOM, Montakarn, Lanchakon CHANUDOM, and Jitbanjong TANGPONG. "Co-treatment Effect of Syzygium cumini (L.) Skeels on Indomethacin Induced Gastric Ulcer on Mice Model." Walailak Journal of Science and Technology (WJST) 16, no. 3 (December 1, 2019): 193–206. http://dx.doi.org/10.48048/wjst.2019.6224.

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Syzygium cumini (L.) Skeels or SCC originally from India and Southeast Asia, commonly used as a medicinal and acted as antioxidant and anti-inflammatory plant. Indomethacin, which is a part of nonsteroidal anti-inflammatory drugs (NSAIDs) family, induced gastric damage and perforation through the excess generation of reactive oxygen species (ROS). This research focus on co-treatment administered between SCC and indomethacin in the subsequent 7 days and evaluated on oxidative damage, inflammatory parameter and epidermal growth factor (EGF) receptor. SCC showed a concentration and dose dependent
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24

Alhakamy, Nabil A., Shaimaa M. Badr-Eldin, Osama A. A. Ahmed, Abdulrahman A. Halwani, Hibah M. Aldawsari, Mohamed A. El-Moselhy, Aliaa Anter, et al. "Optimized Ellagic Acid–Ca Pectinate Floating Beads for Gastroprotection against Indomethacin-Induced Gastric Injury in Rats." Biomolecules 10, no. 7 (July 6, 2020): 1006. http://dx.doi.org/10.3390/biom10071006.

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A peptic ulcer is an alimentary tract injury that leads to a mucosal defect reaching the submucosa. This work aimed to optimize and maximize ellagic acid (EA) loading in Ca pectinate floating beads to maximize the release for 24 h. Three factors were selected: Ca pectinate concentration (X1, 1–3 w/v %), EA concentration (X2, 1–3 w/v %) and the dropping time (X3, 10–30 min). The factorial design proposed eight formulations. The optimized EA–Ca pectinate formulation was evaluated for the gastric ulcer index and the oxidative stress parameter determination of gastric mucosa. The results indicated
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25

Renga, M., G. Brandi, G. M. Paganelli, C. Calabrese, S. Papa, A. Tosti, P. Tomassetti, M. Miglioli, and G. Biasco. "Rectal cell proliferation and colon cancer risk in patients with hypergastrinaemia." Gut 41, no. 3 (September 1, 1997): 330–32. http://dx.doi.org/10.1136/gut.41.3.330.

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Background—The influence of gastrin on the colonic mucosa is still uncertain. Some authors have suggested a stimulating effect on the growth of normal and malignant colonic epithelium, while others have shown no association between gastrin and neoplastic development.Aims—To evaluate the effect of gastrin on colorectal cell proliferation, patients with chronic endogenous hypergastrinaemia underwent proctoscopy. Biopsy specimens were taken in order to study rectal cell kinetics.Patients and controls—Ten patients with chronic autoimmune gastritis (CAG), six patients with Zollinger-Ellison syndrom
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26

Lee, Ji Hwan, Hee Jae Kwak, Dongchul Shin, Hye Jin Seo, Shin Jung Park, Bo-Hee Hong, Myoung-Sook Shin, Seung Hyun Kim, and Ki Sung Kang. "Mitigation of Gastric Damage Using Cinnamomum cassia Extract: Network Pharmacological Analysis of Active Compounds and Protection Effects in Rats." Plants 11, no. 6 (March 8, 2022): 716. http://dx.doi.org/10.3390/plants11060716.

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Gastritis is a common disease worldwide that is caused by various causes such as eating habits, smoking, severe stress, and heavy drinking, as well as Helicobacter pylori infections and non-steroidal anti-inflammatory drugs. Cinnamomum cassia is a tropical aromatic evergreen tree commonly used as a natural medicine in Asia and as a functional food ingredient. Studies have reported this species’ anti-obesity, anti-diabetic, and cardiovascular disease suppression effects. We evaluated the potential effects of C. cassia using non-steroidal anti-inflammatory drugs (NSAIDs), ethanol (EtOH), and eth
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27

Paseban, Maryam, Saeed Niazmand, Mohammad Soukhtanloo, Naser T. Meibodi, Abbasali Abbasnezhad, Seyed M. Mousavi, and Mohammad J. Niazmand. "The Therapeutic Effect of Nigella sativa Seed on Indomethacin-induced Gastric Ulcer in Rats." Current Nutrition & Food Science 16, no. 3 (April 27, 2020): 276–83. http://dx.doi.org/10.2174/1573401315666190114152855.

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Background: Nonsteroidal anti-inflammatory drugs (NSAIDs) are widely used to relieve pain and reduce inflammation. However, gastric complications remain a major problem limiting their clinical usage. This study was carried out to evaluate the therapeutic effect of Nigella sativa seed (N. sativa seed) hydroalcoholic extract on indomethacin-induced gastric ulcer in rats and its possible mechanism. Methods: This study was carried out on forty-eight male Wistar rats. Gastric ulcer was induced by indomethacin (35 mg/kg). N. sativa seed extract (100, 200, and 400 mg/kg) and ranitidine (50 mg/kg) was
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28

Chernikov, M. V., M. A. Oganova, A. S. Gerasimenko, and E. A. Artemyev. "ANTIULCER ACTIVITY OF DINITRATE 2-PHENYL-9DIETHYLAMINOETHYLAMINE[1,2-A]BENZIMIDAZOLE WITH HELICOBACTER PYLORI-LIKE DAMAGE OF GASTRIC MUCOSA." Pharmacy & Pharmacology 6, no. 4 (September 12, 2018): 367–79. http://dx.doi.org/10.19163/2307-9266-2018-6-4-367-379.

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The search for new drugs providing effective and safe therapy of acid-dependent diseases of the gastrointestinal tract, continues to be an actual problem of modern pharmacotherapy. One of the most significant pathogenetic mechanisms of these diseases is associated with Helicobacter pylori damage to the gastric mucosa.The aim of this study is the experimental investigation of the antiulcer effect of 2-phenyl-9-diethylaminoethylamine [1,2-a] benzimidazole substance (hereinafter a Benzimidazole derivative substance) on the model of Helicobacter pylori-like gastric mucosal injury in combination wi
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29

Wróblewski, Hubert, and Aleksandra Zimna. "Proton pump inhibitors usage and the risk of cancer." Journal of Education, Health and Sport 11, no. 8 (August 28, 2021): 342–48. http://dx.doi.org/10.12775/jehs.2021.11.08.038.

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Introduction and purpose of the work:Proton pump inhibitors are used to reduce gastric acidity by irreversibly inhibiting the hydrogen-potassium ATPase present in the parietal cells of the stomach. These drugs are used more and more often, often not in accordance with the recommendations. There are reports suggesting a relationship between chronic PPI use and the occurrence of cancer. The aim of the study is to present information on the relationship between the use of proton pump inhibitors and the risk of developing cancer.State of knowledge:Recent field studies have shown that there is a si
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Balasubramanian, T., M. Somasundaram, and A. John William Felix. "Taurine Prevents Ibuprofen-Induced Gastric Mucosal Lesions and Influences Endogenous Antioxidant Status of Stomach in Rats." Scientific World JOURNAL 4 (2004): 1046–54. http://dx.doi.org/10.1100/tsw.2004.207.

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Recently, free radical–induced tissue damage is implicated in the nonsteroidal anti-inflammatory drugs (NSAIDs)–involved gastric mucosal lesion. Administration of taurine, an endogenous antioxidant, is reported to be beneficial in various clinical conditions. Therefore, we decided to study the protective effect of taurine in ibuprofen-induced gastropathy and the effects of administration of taurine on the endogenous antioxidant enzymes such as superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (GPX), and reduced glutathione (GSH) of stomach. In rats, administration of tauri
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Danielewski, Maciej, Sylwia Zielińska, Agnieszka Matuszewska, Wojciech Słupski, Maciej Włodarczyk, Izabela Jęśkowiak, Benita Wiatrak, et al. "Sanguinarine-Chelerythrine Fraction of Coptis chinensis Exerts Anti-inflammatory Activity in Carrageenan Paw Oedema Test in Rats and Reveals Reduced Gastrotoxicity." Oxidative Medicine and Cellular Longevity 2022 (March 16, 2022): 1–12. http://dx.doi.org/10.1155/2022/1504929.

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Inflammatory diseases are a common therapeutic problem and nonsteroidal anti-inflammatory drugs are not deprived of side effects, of which ulcerogenic activity is one of the most frequent. The aim of the study was to evaluate the anti-inflammatory activity of the sanguinarine-chelerythrine (SC) fraction of Coptis chinensis and its influence on the integrity of gastric mucosa. The study was conducted on sixty male rats randomly divided into six experimental groups: two control groups (a negative control group CON and a positive control group CAR); three groups receiving an investigational fract
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Koshurba, I. V., F. V. Hladkykh, and M. O. Chyzh. "EVALUATION OF ANTIULCEROGENIC EFFECT OF CRYOCONSERVATED PLACENTA EXTRACT ON THE MODEL OF ETHANOL-PREDISONOLIC LESIONS OF THE GASTRIC MUCOSA." Medical Science of Ukraine (MSU) 18, no. 2 (June 30, 2022): 3–9. http://dx.doi.org/10.32345/2664-4738.2.2022.01.

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Relevance. Gastric and duodenal ulcers occur in 6-10% of the adult population, and mortality from peptic ulcers ranges from 5 to 15%. Conservative treatment of this disease almost always involves the use of antisecretory and antibacterial drugs. Existing treatment regimens for peptic ulcer disease, focused on key pathogenetic mechanisms, do not take into account the individual adaptive and trophological characteristics of patients. As a potential antiulcer agent, our attention was drawn to the cryopreserved placenta extract ("Cryocell-cryoextract placenta"). It eliminates the ulcerogenic effec
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MANOCHA, Sachin, Dushyant LAL, and Subramanian VENKATARAMAN. "ADMINISTRATION OF H2 BLOCKERS IN NSAID INDUCED GASTROPATHY IN RATS: effect on histopathological changes in gastric, hepatic and renal tissues." Arquivos de Gastroenterologia 53, no. 1 (March 2016): 36–43. http://dx.doi.org/10.1590/s0004-28032016000100008.

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ABSTRACT Background Nonsteroidal anti-inflammatory drugs induces gastric mucosal lesions because of its acidic properties. Ranitidine, an H2 receptor antagonist, has proved beneficial in patients with gastric ulcers. Objective The present study was performed to assess the effect of administering ranitidine in Nonsteroidal anti-inflammatory drugs (diclofenac, nimesulide) induced gastropathy, and their effect on the histopathology of stomach, kidney and liver. Methods Diclofenac, nimesulide, and ranitidine were administered in doses of 2, 4, and 6 mg/kg, p.o. once daily for 14 days, and their ef
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34

Husori, Dadang Irfan, Marianne Marianne, Nabila Deli Syafarina Lubis, Kurnia Lavinda Yusfa, and Intan Farah Diba Angela. "Evaluation of Gastroprotective Effect from Phaleria macrocarpa Fruits Extract on Gastric Ulcer in Male Wistar Rats." Open Access Macedonian Journal of Medical Sciences 10, A (March 15, 2022): 462–69. http://dx.doi.org/10.3889/oamjms.2022.8242.

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Abstract
 
 BACKGROUND: The long-term use of Non-Steroidal Anti-Inflammatory Drugs (NSAIDs) triggers gastric mucosal damage and causes ulcers. Meanwhile, studies showed that God's crown fruit (Phaleria macrocarpa) contains secondary metabolites of flavonoids and tannins that can protect the gastric mucosa.
 AIM: This study aims to determine the gastroprotective effect of P. macrocarpa ethanolic extracts against gastric ulcers in rats induced with acetosal and ethanol. The extracts were obtained by maceration method using 96% ethanol as solvent.
 METHODS: The male rats used
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35

Rahmadi, Mahardian, Nily Su’aida, Pratiwi Yustisari, Wahyu Agung Dewaandika, Elma Oktavia Hanaratri, Mareta Rindang Andarsari, Sumarno, and Toetik Aryani. "Gastroprotective effect of fluvoxamine and ondansetron on stress-induced gastric ulcers in mice." Journal of Basic and Clinical Physiology and Pharmacology 32, no. 4 (June 25, 2021): 485–90. http://dx.doi.org/10.1515/jbcpp-2020-0424.

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Abstract Objectives The association between stress and gastric ulcers has been well reported. This study is divided into two parts: the first part of this study is consisted of analyzing the effect of fluvoxamine administration by intracerebroventricular (ICV) and intraperitoneal (IP) injections on stress-induced gastric ulcers. The second part investigates the effect of ondansetron in influencing the protection of the gastric mucous by giving fluvoxamine to the mice before being induced with stress. Methods Water immersion restraint stress (WIRS) was used to induce stress. Fluvoxamine 50 and
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Ige, Serah Funke, Bolade S. Olateju, Victor A. Oladipupo, Adedayo T. Adekola, and Oluwaseun B. Ademilua. "Role of Low Environmental Temperature in Peptic Ulcer Development." International Journal of Medical Research & Review 9, no. 3 (May 31, 2021): 193–204. http://dx.doi.org/10.17511/ijmrr.2021.i03.10.

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Peptic ulcers are described as acid-induced lesions found in the stomach and duodenum caused bythe imbalance between the defending factors of the mucosa and the attacking factors such ashydrochloric acid in gastric juice, with Helicobacter Pylori (H. Pylori) and Non-Steroidal Anti-Inflammatory Drugs NSAIDs. They exhibit seasonal patterns in their occurrence, with higheroccurrence in winter and spring and a low occurrence in summer. Temperature plays a major role intheir occurrence, some of which have resulted in increased morbidity in some number of diseases,such as gastrointestinal bleeding,
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Afroz, Rumana, Md Ismail Khan, Kazi Afzalur Rahman, Mahbuba Jahan Lotus, Mir muhammad Shoyeb Shahabuddin, Tasnin Afrin, Nahid Yeasmin, and Kawsar Jahan Moon. "Histopathological Evaluation of Gastro Protective Effect of Trigonella Foenum Graecum Seed (Methi) and omeprazole in Experimentally Induced Gastric Ulcer in Rats." Journal of Dhaka Medical College 28, no. 1 (March 3, 2020): 67–75. http://dx.doi.org/10.3329/jdmc.v28i1.45759.

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Context: Peptic ulcer is a common disorder of the stomach and duodenum. Bangladesh is a developing country with a very high point prevalence of duodenal ulcer disease (11.9%) and a H. pylori prevalence of more than 90% in asymptomatic adults and 80% in children at the age of 5 years. The multifactorial pathogenesis of peptic ulcers is secretion of gastric acid. The main therapeutic target is the control of this secretion using antacids, H2 receptor blockers (ranitidine, famotidine) or proton pump blockers (omeprazole and lansoprazole). However, nowadays, gastric ulcer therapy faces a major dra
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Sugiharta, Amelia Dwi Nurulita, I. Gusti Ayu Trisna Windiani, I. Gusti Agung Ngurah Sugitha Adnyana, and I. Gusti Ayu Indah Ardani. "Erocive gastritis with bipolar affective disorder current episode severe depression with psychotic symptoms with history of sexual violence in adolescent." International journal of health & medical sciences 5, no. 4 (October 31, 2022): 313–16. http://dx.doi.org/10.21744/ijhms.v5n4.1995.

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Depression is a mental health disorder characterized by feelings of sadness, unhappiness, hopelessness, and even guilt. Erosive gastritis is an erosion of the gastric mucosa caused by damage to the mucosal barrier that is superficial but does not penetrate the muscularis mucosal layer. The patient is a 17 year old girl. Experiencing sad behavior changes, lack of interest, loss of joy, and suicide attempts. In addition, the patient was vomiting blood, and was examined by a pediatric gastroenterohepatologist. The supporting examination that was carried out, namely endoscopy, showed that the pati
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39

Suchitra M R, Danalakshmi G K, Sampathkumar P, Sumathi S, Poornima A, and Parthasarathy S. "A study of In vitro antioxidant and apoptotic effect of citrus medica Linn. leaves (Naarthai) against human gastric adenocarcinoma cell line (ags)." International Journal of Research in Pharmaceutical Sciences 11, SPL4 (December 21, 2020): 1188–91. http://dx.doi.org/10.26452/ijrps.v11ispl4.4263.

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Carcinoma or cancer of the stomach is one of the common malignancies of older men. Numerous methods of treatment options, including herbal and plant products, have been described for its management. The leaves of citrus medica or the naarthai leaves as it has been named traditionally do possess activities in the gastric mucosa. Hence, we decided to extract the phytochemicals from the leaves and find out the antioxidant, cytotoxic potential of the same. After confirmation of the leaves from appropriate authorities, petroleum ether, ethanolic and aqueous extracts of the leaves were made. The IC
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40

Hawkey, C. J., A. B. Hawthorne, N. Hudson, A. T. Cole, Y. R. Mahida, and T. K. Daneshmend. "Separation of the impairment of haemostasis by aspirin from mucosal injury in the human stomach." Clinical Science 81, s25 (October 1, 1991): 565–73. http://dx.doi.org/10.1042/cs0810565.

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1. An increasing body of data suggests that the anti-haemostatic as well as the ulcerogenic actions of aspirin and other non-steroidal anti-inflammatory drugs may be operative when patients present with haematemesis and melaena. 2. We therefore developed methods to allow separate evaluation of the erosive and anti-haemostatic actions of aspirin in the human gastric mucosa. Volunteer subjects took 300 mg of aspirin daily in the morning or 600 mg of aspirin four times a day for 5 days under blinded randomized conditions. Changes in spontaneous gastric microbleeding, endoscopic signs of injury, s
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41

Bibik, E. Yu, A. V. Myazina, K. A. Frolov, V. V. Dotsenko, and S. G. Krivokolysko. "Impact of new 1,4‑dihydrothiopyridine derivatives with analgesic activity on gastric mucosa." Glavvrač (Chief Medical Officer), no. 9 (August 31, 2022): 16–18. http://dx.doi.org/10.33920/med-03-2209-04.

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In clinical practice, the occurrence of such a side effect as gastrotoxicity can occur in patients taking NSAIDs with any route of administration. In this case, damage not only to the upper parts of the digestive tract is noted, but also to the intestine as a whole, since NSAID-induced enteropathy is manifested by the intestinal permeability disorder with protein exudation and diapedesis of erythrocytes, as well as by the development of erosions, ulcers, and life-threatening complications: bleeding, perforation, intestinal obstruction, and the appearance of circular folds [1]. The purpose of t
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42

Khémiri, Ikram, and Lotfi Bitri. "Effectiveness of Opuntia ficus indica L. inermis Seed Oil in the Protection and the Healing of Experimentally Induced Gastric Mucosa Ulcer." Oxidative Medicine and Cellular Longevity 2019 (November 15, 2019): 1–17. http://dx.doi.org/10.1155/2019/1568720.

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Gastric ulcer is a painful lesion of the gastric mucosa which can be disabling, or even more very serious in the case of a perforation of the stomach and internal hemorrhage. Traditional pharmacopeias have shown the efficacy of various plant extracts in the treatment of this pathology. Some extracts from Opuntia ficus indica (OFI) have been proven to have medicinal therapeutic benefits. The aim of this study was to investigate the preventive and curative effects of OFI seed oil extracted by cold pressing on an ethanol-induced gastric ulcer model in rats. Gastroprotective activities of the oil
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43

Filaretova, Ludmila, Tatiana Podvigina, and Natalia Yarushkina. "Physiological and Pharmacological Effects of Glucocorticoids on the Gastrointestinal Tract." Current Pharmaceutical Design 26, no. 25 (August 4, 2020): 2962–70. http://dx.doi.org/10.2174/1381612826666200521142746.

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The review considers the data on the physiological and pharmacological effects of glucocorticoids on the gastric mucosa and focuses on the gastroprotective role of stress-produced glucocorticoids as well as on the transformation of physiological gastroprotective effects of glucocorticoids to pathological proulcerogenic consequences. The results of experimental studies on the re-evaluation of the traditional notion that stress-produced glucocorticoids are ulcerogenic led us to the opposite conclusion suggested that these hormones play an important role in the maintenance of the gastric mucosal
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44

Waseem, Uzma, Syeda Rizwana Jafri, Sarah Khalid, Fauzia Qureshi, Nadia Majeed, and Ursula Akif. "Anti-inflammatory activity of acacia catechu-bark aqueous solution in aspirin induced gastric ulcer in rodents." International Journal Of Community Medicine And Public Health 8, no. 12 (November 24, 2021): 5649. http://dx.doi.org/10.18203/2394-6040.ijcmph20214551.

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Background: Aspirin is amongst the most widely used drugs and has many adverse effects on gastric mucosa. Anti-inflammatory properties of Acacia catechu have been established already. Objective was to evaluate the histopathological changes induced by aspirin in the stomach of albino rats and to assess the protective effect of different doses of Acacia catechu.Methods: Experimental study Postgraduate Medical Institute, Lahore for 21 days. Forty-eight adult albino rats, both males and female, were divided into four groups A, B, C and D randomly; each comprising of 12 rats. Group A was control, g
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45

Ishikawa, T., B.-L. Zhu, and H. Maeda. "Effects of therapeutic agents on cellular respiration as an indication of metabolic activity." Human & Experimental Toxicology 25, no. 3 (March 2006): 135–40. http://dx.doi.org/10.1191/0960327106ht610oa.

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Animal experiments are indispensable in the investigation of the toxicity of drugs on cells, but may not be preferred for ethical reasons and sensitivity. As an alternative procedure, we investigated the susceptibility of cells to drugs using the effect on cellular respiration as an indicator of cell activity (toxicity). The primary cultures (cell lines) used in this study included human fetal myocardial cells, skeletal muscle cells, nerve cells, hypophyseal cells, epithelial cells of gastric mucosa, lymphocytes, hepatocytes, pancreatic (exocrine) cells, renal tubular epithelial cells and feta
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46

Bibik, E. Yu, A. V. Myazina, K. A. Frolov, V. V. Dotsenko, and S. G. Krivokolysko. "Influence of new 1,4‑dihydrothiopyridine derivatives with analgesic activity on the gastric mucosa." Glavvrač (Chief Medical Officer), no. 7 (July 1, 2022): 9–11. http://dx.doi.org/10.33920/med-03-2207-01.

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In clinical practice, such a side effect as gastrotoxicity can occur in patients taking NSAIDs with any route of administration. In this case, damage not only to the upper parts of the digestive tract, but also to the intestine as a whole is noted, since NSAID-induced enteropathy is manifested by a breach in the intestinal permeability with protein exudation and diapedesis of erythrocytes, as well as by the damage with the development of erosions, ulcers and life-threatening complications: bleeding, perforation, intestinal obstruction, the occurrence of circular structures [1]. The purpose of
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47

Paseban, Maryam, Saeed Niazmand, Mohammad Soukhtanloo, and Naser Tayyebi Meybodi. "The preventive effect of Nigella sativa seed on gastric ulcer induced by indomethacin in rat." Journal of Herbmed Pharmacology 9, no. 1 (January 1, 2020): 12–19. http://dx.doi.org/10.15171/jhp.2020.02.

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Introduction: Nonsteroidal anti-inflammatory drugs (NSAIDs) are considered as one of the most administrated groups of medications worldwide. Due to the role of NSAIDs in inducing gastric ulceration, their clinical applications are still challenging. Nigella sativa seed is widely used as an herbal medication against gastrointestinal complications. The present experiment was carried out to investigate the impact of N. sativa seed hydro-alcoholic extract on gastric ulcer induced by indomethacin (IND) and to evaluate its possible mechanisms in rat. Methods: This study was performed on 48 male Wist
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Frolova, A. A., T. S. Shindina, L. V. Maslovsky, M. L. Maksimov, E. B. Aleksandrova, and O. E. Kropova. "Mechanism of action of gastroprotective agent rebamipide." Glavvrač (Chief Medical Officer), no. 8 (July 25, 2022): 23–25. http://dx.doi.org/10.33920/med-03-2208-06.

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Among the diseases of the digestive system, a significant place is occupied by acid-dependent diseases caused by excessive secretion of hydrochloric acid secreted by the parietal cells of the gastric mucosa. Due to their high prevalence and risk of complications, these pathologies represent a serious medical and social problem. Gastroprotective agents have a protective effect on the mucous membrane of the stomach and intestines. This group of medicines includes a range of drugs that differ in principle and mechanism of action, such as misoprostol, bismuth salts, as well as some herbal preparat
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Takeuchi, Kenichiro, Maki Ohishi, Keiko Endo, Kenichi Suzumura, Hitoshi Naraoka, Takeji Ohata, Jiro Seki, Yoichi Miyamae, Masashi Honma, and Tomoyoshi Soga. "Hydroxyproline, a Serum Biomarker Candidate for Gastric Ulcer in Rats: A Comparison Study of Metabolic Analysis of Gastric Ulcer Models Induced by Ethanol, Stress, and Aspirin." Biomarker Insights 9 (January 2014): BMI.S15918. http://dx.doi.org/10.4137/bmi.s15918.

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Gastrointestinal symptoms are a common manifestation of adverse drug effects. Non-steroid anti-inflammatory drugs (NSAIDs) are widely prescribed drugs that induce the serious side effect of gastric mucosal ulceration. Biomarkers for these side effects have not been identified and ulcers are now only detectable by endoscopy. We previously identified five metabolites as biomarker candidates for NSAID-induced gastric ulcer using capillary electrophoresis–mass spectrometry (CE–MS)-based metabolomic analysis of serum and stomach from rats. Here, to clarify mechanism of changes and limitations of in
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Ye, Junhong, Jifu Li, and Ping Zhao. "The Silkworm Carboxypeptidase Inhibitor Prevents Gastric Cancer Cells’ Proliferation through the EGF/EGFR Signaling Pathway." International Journal of Molecular Sciences 24, no. 2 (January 5, 2023): 1078. http://dx.doi.org/10.3390/ijms24021078.

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Gastric cancer is a common malignant tumor originating from the gastric mucosa epithelium. Studies have shown that bioactive substances such as antimicrobial peptides and cantharidin contained in a variety of insects can exert anti-cancer functions; when compared with chemotherapy drugs, these bioactive substances have less toxicity and reduced side effects. Here, we report the first Bombyx mori carboxypeptidase inhibitor that is specifically and highly expressed in silk glands, which can significantly prevent the proliferation of gastric cancer cells by inhibiting the MAPK/ERK pathway initiat
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