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Tesis sobre el tema "Genetic Mutation"

Autor: Grafiati

Publicado: 4 de junio de 2021

Última modificación: 26 de julio de 2025

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1

Wu, F. "Mutation-based genetic improvement of software." Thesis, University College London (University of London), 2017. http://discovery.ucl.ac.uk/1561361/.

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Genetic Improvement (GI) of software is a recent field that has drawn much attention from Software Engineering researchers. It aims to use search techniques to automatically modify and improve existing software. The drawback in previous GI approaches is scalability of these approaches, due to the large search space formed by the code base in real-world systems. To overcome the scalability challenge, more recent studies have confined the granularity of code modification at the statement level and applied a prior sensitivity analysis to further reduce the search space. However, some software imp

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2

Hoek, Kim G. P. "Mutation screening of pre-eclampsia candidate genes, LEP (ob) and LEPR (obR)." Thesis, Stellenbosch : University of Stellenbosch, 2006. http://hdl.handle.net/10019.1/2834.

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Thesis (MSc (Genetics))--University of Stellenbosch, 2006.<br>Pre-eclampsia is a multisystemic disorder with an incidence of ~6-8% in non-Caucasian women in the Western Cape. Trophoblast invasion is vital for adequate anchorage of the placenta to the uterine wall as well as for the optimisation of utero-placental blood flow in uncomplicated pregnancies. This process is facilitated by the fetal trophoblast cells that digest the extracellular matrix of the uterus by secreting various molecules, including the metalloproteinases (MMP), of which MMP-9 has an increased production during the first tr

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3

Abu-Bakar, Nordin. "Adaptive genetic algorithms." Thesis, University of Essex, 2000. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.343268.

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4

Singleton, Andrew B. "Genetic aspects of dementia." Thesis, University of Newcastle Upon Tyne, 1998. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.299652.

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5

Hui, Wing-sum, and 許永森. "Molecular and mutation analysis of hereditary multiple exostoses." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2002. http://hub.hku.hk/bib/B42577081.

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6

King, Helen Anne. "Phenotypic and genetic analysis of the hindshaker mutation." Thesis, University of Glasgow, 1997. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.241893.

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7

Carvalho, Sara. "Adaptation from standing genetic variation and from mutation." Doctoral thesis, Universidade Nova de Lisboa. Instituto de Tecnologia Química e Biológica, 2012. http://hdl.handle.net/10362/8499.

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Dissertation presented to obtain the Ph.D degree in Evolutionary Biology<br>Understanding the genetic basis of adaptation is crucial to explain the emergence and maintenance of the multitude of life forms we find on Earth today. Perhaps even more importantly, gaining knowledge about how fast organisms can cope with environmental changes may prove crucial in a world being altered at increasing speed due to the human actions. The study of adaptive evolution may therefore have major implications (and applications) in Agriculture, Conservation of endangered species and even Human Health. Natural

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8

Irvine, Alan David. "Mutation analysis in human keratin diseases." Thesis, Queen's University Belfast, 1998. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.268237.

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9

Lewis, Courtney. "Genetics Laboratory Directors’ Perspectives on the Role of Genetic Counselors in Acquired Mutation Testing: Current and Expanded Opportunities." University of Cincinnati / OhioLINK, 2014. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1396523134.

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10

譚麗華 and Lai-wa Tam. "Genetics and development of the oral apparatus in 'paramecium tetraurelia'." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 1985. http://hub.hku.hk/bib/B31207431.

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11

周妙芬 and Miu-fun Chau. "The role of the micronucleus in the development of the oral apparatus of paramecium." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 1987. http://hub.hku.hk/bib/B31208101.

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12

Zhao, Wei, and 趙煒. "BRAF mutation and aberrant methylation of gene promoters in the pathogenesis of gastrointestinal tract adenocarcinoma." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2006. http://hub.hku.hk/bib/B36718464.

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13

Ochoa, Gabriela. "Error thresholds and optimal mutation rates in genetic algorithms." Thesis, University of Sussex, 2000. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.341070.

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14

Hietpas, Ryan T. "Experimental Illumination of Comprehensive Fitness Landscapes: A Dissertation." eScholarship@UMMS, 2013. https://escholarship.umassmed.edu/gsbs_diss/667.

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Evolution is the single cohesive logical framework in which all biological processes may exist simultaneously. Incremental changes in phenotype over imperceptibly large timescales have given rise to the enormous diversity of life we witness on earth both presently and through the natural record. The basic unit of evolution is mutation, and by perturbing biological processes, mutations may alter the fitness of an individual. However, the fitness effect of a mutation is difficult to infer from historical record, and complex to obtain experimentally in an efficient and accurate manner. We have re

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15

Hietpas, Ryan T. "Experimental Illumination of Comprehensive Fitness Landscapes: A Dissertation." eScholarship@UMMS, 2006. http://escholarship.umassmed.edu/gsbs_diss/667.

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Evolution is the single cohesive logical framework in which all biological processes may exist simultaneously. Incremental changes in phenotype over imperceptibly large timescales have given rise to the enormous diversity of life we witness on earth both presently and through the natural record. The basic unit of evolution is mutation, and by perturbing biological processes, mutations may alter the fitness of an individual. However, the fitness effect of a mutation is difficult to infer from historical record, and complex to obtain experimentally in an efficient and accurate manner. We have re

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16

McKenzie, Rod. "Molecular structure of the bifunctional purine biosynthesis pathway genes : Ade1 in Schizosaccharomyces pombe and Ade5, 7 in Saccharomyces cerevisiae." Thesis, University of Edinburgh, 1989. http://hdl.handle.net/1842/12632.

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17

Fjellstedt, Erik. "Clinical and genetic studies on patients with cystinuria /." Linköping : Univ, 2003. http://www.bibl.liu.se/liupubl/disp/disp2003/med817s.pdf.

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18

Welander, Jenny. "Genetic Alterations in Pheochromocytoma and Paraganglioma." Doctoral thesis, Linköpings universitet, Avdelningen för cellbiologi, 2015. http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-114806.

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Pheochromocytomas and paragangliomas are neuroendocrine tumors that arise from neural crest-derived cells of the adrenal medulla and the extra-adrenal paraganglia. They cause hypertension due to an abnormally high production of catecholamines (mainly adrenaline and noradrenaline), with symptoms including recurrent episodes of headache, palpitations and sweating, and an increased risk of cardiovascular disease. Malignancy in the form of distant metastases occurs in 10-15% of the patients. The malignant cases are difficult to predict and cure, and have a poor prognosis. About a third of pheochro

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19

Trentin, Grace. "Dietary effects on spontaneous genetic damage and somatic mutation frequencies." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1997. http://www.collectionscanada.ca/obj/s4/f2/dsk2/ftp01/MQ27384.pdf.

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20

Al-Saktawi, Khalid A. "Phenotypic analysis of rumpshaker mutation on two different genetic backgrounds." Thesis, University of Glasgow, 2002. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.248226.

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21

Bentley, Elizabeth. "Genetic analysis of the myelencephalic blebs mutation on mouse chromosome." Thesis, University College London (University of London), 1997. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.265754.

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22

Richter, James Neal. "On mutation and crossover in the theory of evolutionary algorithms." Thesis, Montana State University, 2010. http://etd.lib.montana.edu/etd/2010/richter/RichterJ0510.pdf.

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The Evolutionary Algorithm is a population-based metaheuristic optimization algorithm. The EA employs mutation, crossover and selection operators inspired by biological evolution. It is commonly applied to find exact or approximate solutions to combinatorial search and optimization problems. This dissertation describes a series of theoretical and experimental studies on a variety of evolutionary algorithms and models of those algorithms. The effects of the crossover and mutation operators are analyzed. Multiple examples of deceptive fitness functions are given where the crossover operator is s

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23

Carr, Martin. "Genetic variation on the fourth chromosome of Drosophila melanogaster." Thesis, University of Nottingham, 2000. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.324481.

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24

Sinclair, Graham Bernard. "Mutation analysis, heterologous expression, and characterization of human glucocerebrosidase." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 2001. http://www.collectionscanada.ca/obj/s4/f2/dsk3/ftp05/NQ62529.pdf.

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25

Ford, Deborah. "Genetic epidemiology of breast and ovarian cancer." Thesis, Institute of Cancer Research (University Of London), 2001. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.367527.

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26

Kostareva, Anna. "Genetic and pathophysiological study of desmin derangements in cardiac disorders /." Stockholm : Karolinska institutet, 2007. http://diss.kib.ki.se/2007/978-91-7357-294-1/.

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27

Hui, Wing-sum. "Molecular and mutation analysis of hereditary multiple exostoses." Click to view the E-thesis via HKUTO, 2002. http://sunzi.lib.hku.hk/hkuto/record/B42577081.

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28

Hunt-Jones, Charlotte Amy. "Mutation analysis of GABAergic neuroinhibitory genes in childhood genetic generalised epilepsies." Thesis, Swansea University, 2015. https://cronfa.swan.ac.uk/Record/cronfa43036.

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Epilepsy affects over 450,000 people in the UK and there are over 50 epilepsy phenotypes; genetic generalised epilepsy (GGE) account for up to 30% of seizure types. It is established that GGE and other neurological disorders are, in some cases, caused by channelopathies within post-synaptic inhibitory neurotransmitter systems such as GAB A (epilepsy) and Glycine (hyperekplexia). GAB A is the primary inhibitory neurotransmitter in the brain and is synthesised from glutamate by GAD65 and 67, and is released from the pre-synaptic nerve terminal into the synaptic cleft, where it binds to post-syna

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29

Mat, Wai Kin. "Genetic code mutants of bacillus subtilis /." View abstract or full-text, 2007. http://library.ust.hk/cgi/db/thesis.pl?BICH%202007%20MAT.

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30

Warwicker, Paul. "Genetic studies into haemolytic uraemic syndrome." Thesis, University of Newcastle Upon Tyne, 2000. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.313270.

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31

Bryant, Kylie. "Genetic Algorithms and the Travelling Salesman Problem." Scholarship @ Claremont, 2000. https://scholarship.claremont.edu/hmc_theses/126.

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Genetic algorithms are an evolutionary technique that use crossover and mutation operators to solve optimization problems using a survival of the fittest idea. They have been used successfully in a variety of different problems, including the traveling salesman problem. In the traveling salesman problem we wish to find a tour of all nodes in a weighted graph so that the total weight is minimized. The traveling salesman problem is NP-hard but has many real world applications so a good solution would be useful. Many different crossover and mutation operators have been devised for the traveling s

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32

Roberts, Jacqueline Lucy. "A study of replicating instabilities in Schizosaccharomyces pombe." Thesis, University of Edinburgh, 1987. http://hdl.handle.net/1842/14296.

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33

Lehtonen, M. (Mervi). "Mitochondrial DNA sequence variation in patients with sensorineural hearing impairment and in the Finnish population." Doctoral thesis, University of Oulu, 2002. http://urn.fi/urn:isbn:9514268490.

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Abstract Sensorineural hearing impairment (SNHI) is a well-recognized manifestation of mitochondrial diseases and occurs either in a non-syndromic form or as a part of a syndrome. Mitochondrial deafness is bilateral, usually progressive and is inherited maternally. Approximately 70% of patients with the most common syndromes, Kearns-Sayre, MELAS or MERRF, have SNHI. Several mutations in mitochondrial DNA (mtDNA) have been found to cause non-syndromic SNHI, including 1555A>G, 7445T>C, 7472insC and 7511T>C. In order to estimate prevalences of pathogenic mtDNA mutations in population-based cohor

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34

Yau, Wai-kwong, and 丘偉光. "Significance of c-kit mutation in RUNX1-RUNX1T1 acute myeloidleukemia." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2010. http://hub.hku.hk/bib/B44659477.

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35

Göransdotter, Ericson Kim. "Genetic studies of familial hemophagocytic lymphohistiocytosis /." Stockholm, 2004. http://diss.kib.ki.se/2004/91-7140-086-9/.

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36

Johnstone, Duncan Bruce. "Genetic analysis of potassium channels in C. elegans /." Thesis, Connect to this title online; UW restricted, 1999. http://hdl.handle.net/1773/4983.

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37

Andreyev, Hubert Jervoise Nicholas. "Kirsten ras mutation in colorectal adenocarcinoma : prognostic indicator and molecular target." Thesis, Institute of Cancer Research (University Of London), 1997. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.266506.

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38

Panton, Nicola. "Mutation analysis of four genes implicated in iron homeostasis in porphyria cutanea tarda (PCT) patients." Thesis, Link to the online version, 2008. http://hdl.handle.net/10019/888.

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39

Owens, Kelly Noel. "Genetic, molecular, and cytological characterization of the paternal effect gene, paternal loss, of Drosophila melanogaster /." Thesis, Connect to this title online; UW restricted, 1996. http://hdl.handle.net/1773/10255.

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40

Starker, Lee. "New Insights in Genetic and Epigenetic Mechanisms Involved in Parathyroid Tumorigenesis." Doctoral thesis, Uppsala universitet, Institutionen för kirurgiska vetenskaper, 2013. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-205587.

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Primary hyperparathyroidism (pHPT) is a pathology associated with one or multiple hyperfunctioning parathyroid glands. The disease prevalence occurs in roughly 1-2% of the population primarily post-menopausal women. The molecular pathology of the disease is poorly understood. Elevated serum calcium levels in the setting of an inappropriately elevated parathyroid hormone level are indicative of the disease process. The ultimate treatment of the disease is to remove the hyperfunctioning gland. The aim of this thesis was to examine potential genetic and epigenetic aberrations that are potenti

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41

Djureinovic, Tatjana. "Investigation of genetic factors involved in colorectal cancer predisposition /." Stockholm, 2006. http://diss.kib.ki.se/2006/91-7140-864-9/.

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42

Ryder-Cook, Allan Stuart. "Molecular genetic mapping of the mdx mutation and the mouse X chromosome." Thesis, University of Cambridge, 1989. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.306503.

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43

Zeng, Zhao-Bang. "Theoretical studies on genetic limits to natural and artificial selection with mutation." Thesis, University of Edinburgh, 1986. http://hdl.handle.net/1842/13251.

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44

Alfred, Jane. "Genetic and phenotypic analysis of Danforth's short-tail mutation in the mouse." Thesis, University of Edinburgh, 1996. http://hdl.handle.net/1842/20818.

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The principle aim of this project was to finely map the proximal region of mouse chromosome 2, in order to identify markers genetically linked to the <I>Sd</I> gene. To do this, an interspecific backcross in which <I>Sd </I>was segregating, was established and the backcross progeny were haplotyped using a panel of simple sequence repeat markers. Potential candidate genes, such as <I>Pax8</I> and <I>vimentin</I>, were excluded by backcross mapping, and markers flanking <I>Sd</I> were identified and utilised in the screening of YAC libraries. YACs isolated with these markers were used to generat

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45

Gong, Fangcheng 1962. "Genetic and cytological studies of the necrotic leaf-spot mutation in cotton." Thesis, The University of Arizona, 1991. http://hdl.handle.net/10150/277845.

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The cotton (Gossypium hirsutum L.) necrotic leaf-spot mutation is due to a single recessive gene. Cytologically the necrotic leaf-spot mutant affects the development and necrosis of leaves associated with the changed staining pattern, contraction and collapse of palisade and spongy parenchyma cells sequentially. The scanning electron microscope revealed that the stomata are also involved or affected by necrosis. The mutation exhibits a slightly deleterious effect on pollen viability, but not on the viability of the embryo.

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46

Zhang, Xinzhao. "Simulation of cardiac pacemaker dysfunction arising from genetic mutations." Thesis, University of Manchester, 2012. https://www.research.manchester.ac.uk/portal/en/theses/simulation-of-cardiac-pacemaker-dysfunction-arising-from-genetic-mutations(017e8599-a29f-4e38-b3af-5a54ae460800).html.

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The sinoatrial node (SAN) is the primary pacemaker in mammalian hearts and is vital to cardiac function. Genetic mutations in SAN can result in lose-of-function of ion channels, consequently arouse sinus node dysfunction (SND), Brugada syndrome (BrS) and progressive cardiac conduction disease (PCCD). The mechanisms underlying the he pathogenesis for cardiac pacemaker dysfunctions associated with genetic mutations has not been defined. In this project, by using computer modeling, mechanisms by which the HCN4 mutations impair cardiac pacemaking and possible pro-arrhythmic effects of ivabradine w

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47

WANG, MIN. "Description and Application of Genetic Algorithm." Thesis, Blekinge Tekniska Högskola, Sektionen för ingenjörsvetenskap, 2012. http://urn.kb.se/resolve?urn=urn:nbn:se:bth-2362.

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Genetic Algorithm (GA) as a class of Evolutionary Algorithm (EA) is a search algorithm based on the mechanics of natural selection and natural genetics. This dissertation presents the description, solving procedures and application of GA. The definitions of selection, crossover and mutation operators are given in details and an application based on GA in Time Table Problem (TTP) is performed in a new way. Due to its high capability of overall search, GA is particularly appropriate for solving timetabling and scheduling problems. TTP (Time Table Problem) which belongs to NP-hard problem is a sp

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48

Saadi, Irfan. "Characterization of the SLC3A1 (D2H) gene and mutation analysis of cystinuria patients in Québec." Thesis, McGill University, 1997. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=20283.

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Cystinuria is an autosomal recessive disorder of the kidneys and intestine with defective luminal transport of cystine and other dibasic amino acids (ornithine, arginine, and lysine). Three phenotypes have been described, based on urinary excretion of these amino acids in obligate heterozygotes: Type I (silent carriers); Type II (moderate elevation); and Type III (mild elevation). The SLC3AI (D2H) protein has been shown to enhance cystine reabsorption and mutations in D2H have been reported in cystinuria. The aims of this study were to characterize D2H gene structure and to identify mutations

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49

Osborne, Kathleen Amy. "Molecular analysis of the foraging microregion in the fruitfly Drosophila melanogaster." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 2000. http://www.collectionscanada.ca/obj/s4/f2/dsk1/tape2/PQDD_0020/NQ56253.pdf.

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50

Harnevik, Lotta. "Molecular genetic studies on cystinuria." Doctoral thesis, Linköping : Univ, 2007. http://www.bibl.liu.se/liupubl/disp/disp2007/med1034s.pdf.

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