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Tesis sobre el tema "Glucomannanes"

Autor: Grafiati

Publicado: 4 de junio de 2021

Última modificación: 20 de abril de 2024

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1

Nervo, Roberto. "ETUDE DE L'OXYDATION ET DE L'HYDROLYSE EN MILIEU DIPHASIQUE SOLIDE-GAZ DES GLUCOMANNANES ET D'AUTRES POLYSACCHARIDES." Phd thesis, Grenoble, 2010. http://tel.archives-ouvertes.fr/tel-00465186.

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Le travail présenté dans ce mémoire porte sur la modification d'un polysaccharide extrait d'un tubercule d'espèces d'Amorphophallus konjac sp., une plante pérenne appartenant à la famille des Araceae. Ce polysaccharide, le glucomannane, est un copolymère linéaire soluble dans l'eau, constitué de résidus D-mannopyranosyle (M) et D-glucopyranosyle (G) liés en β-(1→4) (M/G ≅ 1,6) et la chaîne principale présente des groupements acétyles. La masse molaire varie de 4.105 à 2.106 g.mol-1 selon les sources botaniques et les méthodes de purification, et l'étude de sa structure ainsi que ses propriétés

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2

Dorthe, Sandrine. "Caractérisation de farines et de glucomannanes de Konjac selon l'origine botanique et le procédé de fabrication-purification." Université Joseph Fourier (Grenoble), 2005. http://www.theses.fr/2005GRE10006.

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La société KALYS, a initié cette thèse, réalisée en collaboration avec le CERMAV, CNRS. 28 échantillons représentatifs des espèces principales de konjac (Amorphophallus sp. ) en Asie sont étudiés. Les farines sont d'abord comparées selon l'espèce de konjac et le traitement de purification. Quelle que soit l'espèce, la structure moléculaire et la masse molaire du glucomannane (KGM) des farines brutes sont similaires. Les éléments nouveaux pour la connaissance fondamentale du KGM sont : la longueur maximale des blocs de résidus enchaînés, la distribution des groupements acétyles et leur position

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3

Meissonnier, Guylaine. "Effets toxiques de l'aflatoxine b1 et de la toxine t-2 sur les systèmes de défenses métaboliques et immunitaires chez le porc, évaluation des effets protecteurs de glucomannanes." Toulouse 3, 2007. http://www.theses.fr/2007TOU30153.

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L'aflatoxine B1 (AFB1) et la toxine T-2 sont des mycotoxines, métabolites secondaires de micromycètes qui peuvent contaminer les denrées alimentaires notamment les céréales. Les objectifs de nos travaux ont été de déterminer chez le porc, une espèce cible et sensible aux mycotoxines, les effets toxiques de l'AFB1 et de la toxine T-2 sur deux systèmes de défense, les enzymes de biotransformation et l'immunité. De plus, nous avons évalué in vivo l'effet protecteur d'un potentiel liant de toxine. Chez le porc, l'exposition à l'AFB1 aux doses testées n'a pas provoqué de manifestations cliniques ma

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4

Denagbe, Wilfried. "Lipides et polysaccharides extraits du fruit du palmier Acrocomia aculeata (moucaya) : Structures, propriétés antioxydantes, émulsifiantes et formation de nano-vecteurs." Electronic Thesis or Diss., Guyane, 2023. http://www.theses.fr/2023YANE0006.

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Acrocomia aculeata (« moucaya », en créole guyanais) est un palmier indigène de Guyane et d’Amazonie. Bien que ses fruits soient riches en lipides (0,1 à 83% de la matière fraîche pour le mésocarpe du fruit) et en glucides (6 à 98% de la matière fraîche pour le mésocarpe du fruit), seuls les lipides sont valorisés comme sources de biocarburants (biodiesel et biokérosène) dans la sous-région amazonienne, en raison du manque de connaissance sur la nature chimique des glucides. En Guyane, le fruit ne fait l’objet d’aucune valorisation et ses capacités antioxydantes restent mal connues. Pour palli

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5

Rajabi-Nassab, Farhad. "Étude structurale des polysaccharides d'Aloë Vahombe (Liliacées) et d'un polysaccharide des parois de Micromonospora SpF₃ (Actinomycétales)." Paris 11, 1989. http://www.theses.fr/1989PA112283.

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The work describes in this these is divided in two parts. 1 - The polysaccharides mixture obtained by hot water extraction of Aloe Vahombe leaves is composed of at least four different partially acetylated beta ( 1-4) glucomanns, which differ in molecular weight glucose to mannose ratios and acetyl contents. Futhermore, on fraction contains a small but significant amount of protein. 2- The structure of the Micromonospora cell wall polysaccharide has been investigated by using methylation. Smith degradation, partial hydrolyses and NMR spectroscopy. Its components are N-acetylglucosamine, D-mann

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6

Lafarge, Céline. "Impact du glucomannane de konjac sur les interactions composés volatils - amidon de pomme de terre dans un gel hydraté." Thesis, Dijon, 2016. http://www.theses.fr/2016DIJOS007/document.

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L’objectif de ce travail est de démontrer que la présence de glucomannane de konjac (KGM) dans une matrice d’amidon de pomme de terre permet d’accroître sa stabilité physique sans inhiber l’encapsulation moléculaire de composés d’arôme par l’amylose. Pour cette étude, les deux polyosides choisis sont issus de tubercules de plantes abondantes dans la nature.L’amidon est connu pour interagir avec des composés volatils, soit en les piégeant dans la zone amorphe, soit en formant des complexes d'inclusion. Ce phénomène est appelé encapsulation moléculaire. Cependant, les matrices amylacées à forte

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7

Shahbuddin, M. "Development of konjac glucomannan hydrogels for wound healing." Thesis, University of Sheffield, 2014. http://etheses.whiterose.ac.uk/5147/.

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The research presented in this thesis explores the potential uses of KGM and the development of KGM containing hydrogels for wound healing applications. The work involved characterization of five different species of Amorphophallus and investigating the biological activity of KGM and different molecular weight fractions of KGM on skin cells. KGM stimulated fibroblast (but not keratinocyte) proliferation and these effect were influenced by the species, Glc:Man ratio, % of glucomannan, molecular weight and the treatments of KGM. KGM also had the ability to maintain fibroblasts and ADMSC viabilit

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8

Falcucci, Marianna. "Studio dell'attività idrolitica di glucomannano ad opera di alcuni preparati enzimatici industriali." Master's thesis, Alma Mater Studiorum - Università di Bologna, 2016. http://amslaurea.unibo.it/10061/.

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Over the last few decades, polysaccharides have gained increasing attention in the biomedical and drug delivery fields. Among them, glucomannan (GM) has become a particularly interesting polymer in the nutraceutical, pharmaceutical and cosmeceutical field, however the high molecular weight of this natural polymer is the cause of the limits to its application that reflected in a poor solubility in water.Reduce the molecular weight could improve its use and at the same time does not eliminate its properties. In this study, we investigated the ability of enzymes to hydrolyze the polysaccharide st

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9

Khanna, Sheila. "The chemical, physical and nutritional properties of the plant polysaccaride konjac glucomannan." Thesis, Glasgow Caledonian University, 2003. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.688245.

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10

Yoshida, Makiko. "Plant sterols and glucomannan as hypocholesterolemic and hypoglycemic agents in subjects with and without type 2 diabetes." Thesis, McGill University, 2003. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=80900.

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The objective of this research was to examine the effects of plant sterols and glucomannan on lipid profiles, plasma plant sterol levels and glycemic control in mildly hypercholesterolemic subjects. Thirteen type 2 diabetic and sixteen non-diabetic individuals participated in a randomized crossover trial consisting of 4 phases, of 21 days each. During the study period, subjects were supplemented with plant sterols and/or glucomannan. Overall reductions of total cholesterol and low-density lipoprotein (LDL) cholesterol concentrations were greater after consumption of plant sterols and gl

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11

Zhang, Quimang [Verfasser], Petra [Akademischer Betreuer] Mischnick та Hans-Joachim [Akademischer Betreuer] Jördening. "Study on Stereochemistry and Regioselective Methylation in 1,4-β-Glucomannan / Quimang Zhang ; Petra Mischnick, Hans-Joachim Jördening". Braunschweig : Technische Universität Braunschweig, 2019. http://d-nb.info/118194614X/34.

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12

Zhang, Quimang Verfasser], Petra [Akademischer Betreuer] Mischnick та Hans-Joachim [Akademischer Betreuer] [Jördening. "Study on Stereochemistry and Regioselective Methylation in 1,4-β-Glucomannan / Quimang Zhang ; Petra Mischnick, Hans-Joachim Jördening". Braunschweig : Technische Universität Braunschweig, 2019. http://nbn-resolving.de/urn:nbn:de:gbv:084-2019032608291.

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13

Johansson, Dan. "Carbohydrate degradation and dissolution during Kraft cooking : Modelling of kinetic results." Licentiate thesis, Karlstad University, Faculty of Technology and Science, 2008. http://urn.kb.se/resolve?urn=urn:nbn:se:kau:diva-1626.

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<p>Chemical pulp fibres from wood are commonly used in products associated with packaging as well as with printing and writing. The prevalent way of liberating fibres is by subjecting wood chips to Kraft cooking. This process has a history of almost 130 years and should be both well described and well established. However, new products and new applications that use fibres as an important renewable resource make it all the more important that the properties of fibres be controllable. The properties of wood fibres are influenced by their carbohydrate composition which, in turn, is dependent on t

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14

Barake, Roula. "Effects of plant sterols and glucomannan on parameters of cholesterol kinetics in hyperlipidemic individuals with and without type 2 diabetes." Thesis, McGill University, 2005. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=83964.

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The objective of this study was to examine the effects of plant sterols and/or glucomannan on lipid profiles and cholesterol kinetics in hyperlipidemic individuals with or without type 2 diabetes. It was hypothesized that plant sterols and glucomannan reduce circulating cholesterol levels and may have an additive or synergistic effect when combined by reducing cholesterol absorption. Thirteen type 2 diabetics and sixteen non-diabetics all mildly hypercholesterolemic free living subjects participated in a randomized crossover trial consisting of 4 phases, 21 days each. Subjects consumed

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15

Svedinger, Andersson Maria. "The Effect of Different Xylan Contents on the Strength Properties of Softwood Kraft pulp." Thesis, Karlstads universitet, Fakulteten för teknik- och naturvetenskap, 2013. http://urn.kb.se/resolve?urn=urn:nbn:se:kau:diva-28850.

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The aim of this Master thesis was to investigate if the xylan content had any influence on the physical properties of softwood kraft pulps. To achieve pulps with different xylan content different kraft cooking conditions were used; two different temperatures and two different effective alkali levels. The cooking conditions used were 160°C with 30% effective alkali (EA) referred to as reference cook and 145°C with 17% effective alkali (EA) referred to as the mild cook. The first step in this study was to determine the cooking time needed for reaching a certain kappa number, i.e.30. It was also

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16

Deshpande, Raghu. "The initial phase of the sodium bisulfite pulping of softwood dissolving pulp." Licentiate thesis, Karlstads universitet, Institutionen för ingenjörs- och kemivetenskaper, 2015. http://urn.kb.se/resolve?urn=urn:nbn:se:kau:diva-36494.

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The sulfite pulping process is today practised in only a small number of pulp mills around the globe and the number of sulfite mills that use sodium as the base (cation) is less than five. However, due to the increasing interest in the wood based biorefinery concept, the benefits of sulfite pulping and especially the sodium based variety, has recently gained a lot of interest. It was therefore considered to be of high importance to further study the sodium based sulfite process to investigate if its benefits could be better utilized in the future in the production of dissolving pulps. Of speci

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17

Uttpatel, Rodrigo. "NÍVEIS BAIXOS DE AFLATOXINAS DIETÉTICAS E ADSORVENTES NO DESEMPENHO DE MATRIZES DE CORTE E DE SUA PROGÊNIE." Universidade Federal de Santa Maria, 2007. http://repositorio.ufsm.br/handle/1/10706.

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This study was conducted to investigate the effect of the consumption of aflatoxins and adsorbents (esterifid glucomannan) for broiler breeders on productive and reproductive aspects addition to verify the residual effects on the progeny. Four experiments were conducted, with the first consisting of 240 broiler breeders feed with increasing levels of aflatoxins, according to the treatment: T1 free aflatoxins diet and treatments T2, T3 and T4, dies containing 0.250, 0.500 and 0.750mg the aflatoxins/kg of diet. The second experiment was composed of 300 broiler breeders submitted to diets contain

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18

Hoar, Melanie E. "USE OF MTB-100TM, PROVIDED THROUGH A MINERAL MIX, TO REDUCE TOXICITY WHEN LACTATING BEEF COWS GRAZE ENDOPHYTE-INFECTED TALL FESCUE." UKnowledge, 2013. http://uknowledge.uky.edu/animalsci_etds/20.

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Two experiments were conducted at the University of Kentucky, Eden Shale Farm, Owenton, KY to evaluate the use of MTB-100TM (Alltech, Inc., Nicholasville, KY) to alleviate the symptoms of fescue toxicity when lactating Angus x Beefmaster cows and their calves grazed endophyte-infected KY-31 tall fescue. Experiment 1 provided a carbohydrate based toxin adsorbent, MTB-100TM, ad libitum in a commercial mineral supplement to project a daily consumption rate of 0, 20 or 40 g of MTB-100TM per cow. Cows were weighed, assigned a body condition score (BCS) and hair coat score (HC), rectal temperatures

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19

Yee, Melinda Chua Fui. "An investigation of the biology and chemistry of the Chinese medicinal plant, Amorphophallus konjac." Thesis, University of Wolverhampton, 2011. http://hdl.handle.net/2436/237603.

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Konjac glucomannan (KGM), the main biologically active constituent of konjac flour extracted from corms of Amorphophallus konjac (konjac), can be used to prepare functional foods and may also have potential as a pharmaceutical product to combat obesity. The current study employed three experimental approaches to study the biology and chemistry of konjac, namely (1) glasshouse experiments to study the morphogenesis, growth and productivity of konjac plants, (2) a histological and immunocytochemical investigation of the localisation and developmental regulation of the deposition and metabolism o

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20

Åkerholm, Margaretha. "Ultrastructural Aspects of Pulp Fibers as Studied by Dynamic FT-IR Spectroscopy." Doctoral thesis, KTH, Fibre and Polymer Technology, 2003. http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-3609.

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<p>Dynamic (or 2D) FT-IR spectroscopy in combination withpolarized IR irradiation has been used in this work to studywood polymer orientation and interactions on theultrastructural level in wood fibers in the native state aswell as the effects of different pulping processes. The woodpolymer interactions were studied under both dry and humidconditions.</p><p>The matrix of lignin and hemicelluloses located between thewell-ordered cellulose fibrils in the wood cell wall of sprucewas here shown to be more highly ordered than has earlier beenrevealed. It was confirmed that glucomannan is orientedpa

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21

Deshpande, Raghu. "The initial phase of sodium sulfite pulping of softwood : A comparison of different pulping options." Doctoral thesis, Karlstads universitet, Institutionen för ingenjörs- och kemivetenskaper, 2016. http://urn.kb.se/resolve?urn=urn:nbn:se:kau:diva-46929.

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Single stage and two-stage sodium sulfite cooking were carried out on either spruce, pine or pure pine heartwood chips to investigate the influence of several process parameters on the initial phase of such a cook down to about 60 % pulp yield. The cooking experiments were carried out in the laboratory with either a lab-prepared or a mill-prepared cooking acid and the temperature and time were varied. The influences of dissolved organic and inorganic components in the cooking liquor on the final pulp composition and on the extent of side reactions were investigated. Kinetic equations were deve

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22

Klinthong, Worasaung, and 詹木泉. "Gelation Behavior of Konjac Glucomannan." Thesis, 2009. http://ndltd.ncl.edu.tw/handle/69647444952479443444.

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碩士<br>南台科技大學<br>化學工程與材枓工程系<br>97<br>This research studies the gelation behavior of konjac glucomannan (KGM) gel and konjac glucomannan and xanthan (KGM/XG) mixed gels described by the cascade model to understand the mechanism of gelation and the nature of their junction zones. The KGM and XG with molecular weights of 4.75  105 g/mol and 9.80  105 g/mol, respectively, are used as samples. During pretest, there is some liquid phase separating from gel phase, which is called syneresis. Thus, the syneresis of KGM gel is studied on the effect of concentration and aging times. It is shown that

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23

Hsu, Chau-Yang, and 許朝揚. "kinetics of Ag+ ion adsorption by phosphorylated konjac glucomannan and Ag+ ion release from Ag@phosphorylated konjac glucomannan hydrogel." Thesis, 2018. http://ndltd.ncl.edu.tw/handle/daahr3.

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碩士<br>國立中興大學<br>化學系所<br>106<br>In the modern age, it is foreseeable that more and more elderly people and the diabetics may experience slow wound healing when they are injured. One way to solve this problem is to choose a suitable dressing. Hydrophilic dressings can effectively reduce the healing time. This article selected glucomannan as the research object. It has water-absorptive properties and can be used as a material for hydrophilic dressings. Silver ions have a sterilizing function and are often used as medical disinfectants. With its bactericidal properties, it can make dressings resis

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24

Silva, Daniela Catarina Almeida. "Purification of Konjac Glucomannan for Tissue Engineering Applications." Master's thesis, 2020. https://hdl.handle.net/10216/128524.

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Silva, Daniela Catarina Almeida. "Purification of Konjac Glucomannan for Tissue Engineering Applications." Dissertação, 2020. https://hdl.handle.net/10216/128524.

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26

Mills, Rodney Lynn. "Supplementation of Energy and Glucomannan to Alleviate Tall Fescue Toxicosis." 2007. http://trace.tennessee.edu/utk_gradthes/311.

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An 84 d randomized block design using 96 beef calves (238.8 + 20.1 kg) in each of two years was used to assess the efficacy of energy supplementation and glucomannan (MTB) to alleviate tall fescue toxicosis. Groups of four calves were randomly assigned to 24 endophyte-infected tall fescue pastures (1.23 + 0.06 ha). Pastures of calves were randomly assigned to treatments: unsupplemented (CON), supplemented with soybean hulls (SH) at 0.33% BW (DM basis; LO), supplemented with SH at 0.66% BW (DM basis; HI), LO plus 20 g·hd-1·d-1 MTB-100® (LO-MTB), HI plus 20 g·hd-1·d-1 MTB-100® (HI-MTB). Calves w

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27

Redondo, Marta Filipa da Silva. "Konjac glucomannan photocrosslinked hydrogels for in vitro 3D cell culture." Master's thesis, 2020. https://hdl.handle.net/10216/130779.

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28

Wang, Ying-Chu, and 王瑩筑. "Bioactive structure and molecular property of konjac glucomannan: immunomodulatory viewpoint." Thesis, 2009. http://ndltd.ncl.edu.tw/handle/p4h5pe.

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碩士<br>靜宜大學<br>食品營養研究所<br>97<br>This study was to investigate the in vitro and in vivo immunostimulatory effect of konjac glucomannan (KM) and its acid-hydrolyzate fractions KMAF1 (MW &gt;100kDa)、KMAF2 (MW10~100kDa) and KMAF3 (MW &lt;10kDa). All KM samples prepared were composed of D-mannose and D-glucose at a ratio of 1.6:1. The in vitro results on Raw264.7 cell macrophage indicate that all KM samples examined significantly promoted the macrophage viability, where the samples of Mw &gt; 10kDa (KM, KMAF1 and KMAF2) induced significantly production of nitric oxide, TNF-, and IL-6. B

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29

Redondo, Marta Filipa da Silva. "Konjac glucomannan photocrosslinked hydrogels for in vitro 3D cell culture." Dissertação, 2020. https://hdl.handle.net/10216/130779.

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30

Shahbuddin, M., A. J. Bullock, S. MacNeil, and Stephen Rimmer. "Glucomannan-poly(N-vinyl pyrrolidinone) bicomponent hydrogels for wound healing." 2014. http://hdl.handle.net/10454/10531.

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No<br>Polysaccharides interact with cells in ways that can be conducive to wound healing. We have recently reported that konjac glucomannan (KGM) which is comprised of D-mannose and D-glucose linked by beta-1,4 glycosidic chains, stimulates fibroblast proliferation. The aim of this study was to produce a range of crosslinked KGMs and bicomponent KGM containing hydrogels and to examine their potential for wound healing. Two types of KGM hydrogel were synthesized, biodegradable from crosslinked KGM and non-biodegradable by forming semi-IPNs and graft-conetworks with a second synthetic component,

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31

Correia, Viviana Gomes. "Genetic and functional analysis of the bacillus subtilis BSP1 gam cluster." Master's thesis, 2012. http://hdl.handle.net/10362/13961.

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Mannans (linear mannan, glucomannan, galactomannan and galactoglucomannan) are the major constituents of the hemicellulose fraction in softwoods and show great importance as a renewable resource for fuel or feedstock applications. As complex polysaccharides, mannans can only be degraded through a synergistic action of different mannan-degrading enzymes, mannanases. Microbial mannanases are mainly extracellular enzymes that can act in wide range of pH and temperature, contributing to pulp and paper, pharmaceutical, food and feed, oil and textile successful industrial applications. Knowing and

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32

Ying-Hsin and 范櫻馨. "Effects of konjac glucomannan and its hydrolysates on bowel habits, ecosystem, and lipid metabolism." Thesis, 2003. http://ndltd.ncl.edu.tw/handle/02592394317452939211.

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碩士<br>中山醫學大學<br>營養學研究所<br>93<br>The aim of this study is to investigate the effects of Amorphophallus konjac and its hydrolysates on bowel habits, fecal characteristics, food intake, body weight change, lipid metabolism and intestinal hydrolase activities of BALB/c mice. The time-dependent effects of cellulose (C), konjac (K) and konjac hydrolysates (KH) were first investigated. 7 wk mice were randomly allocated to 5% cellulose diet (2 or 4 wk feeding), 5% konjac diet (2 or 4 wk feeding) and 5% konjac hydrolysates diet (2 or 4 wk feeding). We have found that various diets did not cause differ

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33

König, Dagmar [Verfasser]. "Natrium-Carboxymethylstärke und Konjac-Glucomannan als abbaubare Hilfsstoffe für das Colon-Targeting / vorgelegt von Dagmar König." 2005. http://d-nb.info/973688637/34.

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34

HUEY, TEY SZE, and 鄭詩慧. "Effects of Konjac Glucomannan, Inulin Oligosaccharide and Grifola frondosa Extracts in Colitis-associated Colon Carcinogenesis Mouse Model." Thesis, 2017. http://ndltd.ncl.edu.tw/handle/aj9haq.

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35

Pintão, Inês Maria Rodrigues. "Development of a bi-functional 3D scaffold composed by glucomannan and biphasic calcium phosphates for bone tissue engineering applications." Master's thesis, 2020. https://hdl.handle.net/10216/130761.

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Pintão, Inês Maria Rodrigues. "Development of a bi-functional 3D scaffold composed by glucomannan and biphasic calcium phosphates for bone tissue engineering applications." Dissertação, 2020. https://hdl.handle.net/10216/130761.

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37

Tsai, Yi-Ting, and 蔡怡婷. "Effects of konjac glucomannan and inulin oligosaccharide on tumor development and immune function in colitis-associated colon carcinogenesis mouse model." Thesis, 2013. http://ndltd.ncl.edu.tw/handle/26455294873617387168.

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碩士<br>中山醫學大學<br>營養學研究所<br>101<br>Objectives. The aim of study was to determine effects of konjac glucomannan (KGM) and inulin oligosaccharide on tumor development, immune function, intestinal ecology and its mechanisms using a colitis-associated colon carcinogenesis mouse model. Materials and Methods. Six-week-old C57BL/6J male mice were fed control diet (AIN-93G) and initially divided into vehicle control and AOM-DSS groups for 50 days. The AOM-DSS group was administered with a single carcinogen azoxymethane (AOM) (i.p., 10 mg/kg BW) and three cycles of 1-1.5% (w/v) dextran sodium sulfate (DS

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38

Wen-Tzu and 吳文慈. "The modulatory effects of konjac glucomannan on high fat-related risk factors of colon carcinogenesis - clinical, animal and cell line studies." Thesis, 2012. http://ndltd.ncl.edu.tw/handle/r76zav.

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博士<br>中山醫學大學<br>營養學研究所<br>100<br>Konjac glucomannan (KGM), a viscous dietary fiber, has been shown to improve the health of colonic environment by promoting the growth of probiotics and production of short-chain fatty acids (SCFA) in humans and mice. The aim of my doctoral research was to investigate the roles of KGM in prevention risk factors of colon cancer in clinical and animals studies, and to determine its potential anti-cancer effects in human adenocarcinoma cell line model. In the first study, the effects of KGM supplementation into a low-fiber diet on precancerous markers of colon c

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