Bibliografías temáticas / Granule de birbeck

Literatura académica sobre el tema "Granule de birbeck"

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Publicado: 20 de abril de 2024

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Artículos de revistas sobre el tema "Granule de birbeck":

Mc Dermott, Ray, Umit Ziylan, Danièle Spehner, Huguette Bausinger, Dan Lipsker, Mieke Mommaas, Jean-Pierre Cazenave et al. "Birbeck Granules Are Subdomains of Endosomal Recycling Compartment in Human Epidermal Langerhans Cells, Which Form Where Langerin Accumulates". Molecular Biology of the Cell 13, n.º 1 (enero de 2002): 317–35. http://dx.doi.org/10.1091/mbc.01-06-0300.

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Birbeck granules are unusual rod-shaped structures specific to epidermal Langerhans cells, whose origin and function remain undetermined. We investigated the intracellular location and fate of Langerin, a protein implicated in Birbeck granule biogenesis, in human epidermal Langerhans cells. In the steady state, Langerin is predominantly found in the endosomal recycling compartment and in Birbeck granules. Langerin internalizes by classical receptor-mediated endocytosis and the first Birbeck granules accessible to endocytosed Langerin are those connected to recycling endosomes in the pericentriolar area, where Langerin accumulates. Drug-induced inhibition of endocytosis results in the appearance of abundant open-ended Birbeck granule-like structures appended to the plasma membrane, whereas inhibition of recycling induces Birbeck granules to merge with a tubular endosomal network. In mature Langerhans cells, Langerin traffic is abolished and the loss of internal Langerin is associated with a concomitant depletion of Birbeck granules. Our results demonstrate an exchange of Langerin between early endosomal compartments and the plasma membrane, with dynamic retention in the endosomal recycling compartment. They show that Birbeck granules are not endocytotic structures, rather they are subdomains of the endosomal recycling compartment that form where Langerin accumulates. Finally, our results implicate ADP-ribosylation factor proteins in Langerin trafficking and the exchange between Birbeck granules and other endosomal membranes.

González, M. A. Martinez y MaPaz Ortega Serrano. "Birbeck-Like Granule in an Epithelial Cell". Ultrastructural Pathology 18, n.º 4 (enero de 1994): 457–58. http://dx.doi.org/10.3109/01913129409023218.

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Chabrol, Eric, Michel Thépaut, Colette Dezutter-Dambuyant, Corinne Vivès, Julien Marcoux, Richard Kahn, Jenny Valladeau-Guilemond, Patrice Vachette, Dominique Durand y Franck Fieschi. "Alteration of the Langerin Oligomerization State Affects Birbeck Granule Formation". Biophysical Journal 108, n.º 3 (febrero de 2015): 666–77. http://dx.doi.org/10.1016/j.bpj.2014.10.075.

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Guenova, Emmanuella y Martin Schaller. "Residents’ corner September 2011. CarpeDIEM – Birbeck granule in Langerhans cell histiocytosis". European Journal of Dermatology 21, n.º 5 (septiembre de 2011): 827. http://dx.doi.org/10.1684/ejd.2011.1540.

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Thépaut, Michel, Jenny Valladeau, Alessandra Nurisso, Richard Kahn, Bertrand Arnou, Corinne Vivès, Sem Saeland et al. "Structural Studies of Langerin and Birbeck Granule: A Macromolecular Organization Model†‡". Biochemistry 48, n.º 12 (31 de marzo de 2009): 2684–98. http://dx.doi.org/10.1021/bi802151w.

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ASANO, Shoichi, Yuko SONODA y Seichiro SAGAMI. "Birbeck granule-like structure (BgS) observed in lymph nodes of DNCB-sensitive mice." Nishi Nihon Hifuka 48, n.º 1 (1986): 61–69. http://dx.doi.org/10.2336/nishinihonhifu.48.61.

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Bucana, Corazon D., C. Gwyneth Munn, Min Ja Song, Kenneth Dunner y Margaret L. Kripke. "Internalization of Ia Molecules into Birbeck Granule-Like Structures in Murine Dendritic Cells". Journal of Investigative Dermatology 99, n.º 4 (octubre de 1992): 365–73. http://dx.doi.org/10.1111/1523-1747.ep12616079.

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Strunk, D., K. Rappersberger, C. Egger, H. Strobl, E. Kromer, A. Elbe, D. Maurer y G. Stingl. "Generation of human dendritic cells/Langerhans cells from circulating CD34+ hematopoietic progenitor cells". Blood 87, n.º 4 (15 de febrero de 1996): 1292–302. http://dx.doi.org/10.1182/blood.v87.4.1292.bloodjournal8741292.

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Human Langerhans cells (LC) are CD1a+ dendritic cells (DC) that function as potent antigen-presenting cells for primary and secondary immune responses. Limitations in DC/LC numbers, imposed by difficult and tedious isolation procedures, have so far precluded their use as immunogens in the generation and/or augmentation of host responses against various pathogens. Therefore, we have developed a procedure for the generation of human DC/LC from CD34+ hematopoietic progenitor cells (HPC) isolated (mean: 0.7 x 10(6)/ buffy coat and 2.6 x 10(6)/leukapheresis product) and purified ( > 95%) from the peripheral blood of healthy adults. In vitro stimulation of these cells with granulocyte-macrophage colony-stimulating factor (GM-CSF) and tumor necrosis factor (TNF)-alpha led to their vigorous proliferation and differentiation resulting in the emergence of CD45+/CD68+/CD3-/CD19- /CD56- leukocytes some of which (mean: 12%) express CD1a and exhibit anti-CD4 and anti-major histocompatibility complex (MHC) class II reactivity. These CD1a- leukocytes include (1) LC as evidenced by the presence of Birbeck granules (BG), (2) CD14+ monocytes, and (3) Birbeck granule-negative cells with a dendritic morphology. Addition of interleukin (IL)-4 to the cytokine cocktail interfered with the development of monocytes and led to a reduction in the overall yield but, on the other hand, resulted in an increased percentage of CD1a+ cells (mean: 24%) among all cells generated. In vitro generated CD1a+, but not CD1a- HPC-derived cells are potent stimulators of the primary mixed leukocyte reaction and, as such, promising candidates for vaccination purposes.

Strunk, Dirk, Claudia Egger, Gerda Leitner, Daniel Hanau y Georg Stingl. "A Skin Homing Molecule Defines the Langerhans Cell Progenitor in Human Peripheral Blood". Journal of Experimental Medicine 185, n.º 6 (17 de marzo de 1997): 1131–36. http://dx.doi.org/10.1084/jem.185.6.1131.

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We have recently described a system for the generation of dendritic cells (DC) and Langerhans cells (LC) from defined CD34+ precursors purified from peripheral blood of healthy adult volunteers (1). This study has now been extended by the characterization of two distinct subpopulations of CD34+ cells in normal human peripheral blood as defined by the expression of the skin homing receptor cutaneous lymphocyte-associated antigen (CLA). CD34+/CLA+ cells from normal peripheral blood were found to be CD71LOW/CD11a+/CD11b+/CD49d+/ CD45RA+ whereas CD34+/CLA− cells displayed the CD71+/CD11aLOW/CD11bLOW/CD49d(+)/ CD45RALOW phenotype. To determine the differentiation pathways of these two cell populations, CD34+ cells were sorted into CLA+ and CLA− fractions, stimulated with GM-CSF and TNF-α in vitro, and then were cultured for 10 to 18 d. Similar to unfractionated CD34+ cells, the progeny of both cell populations contained sizable numbers (12–22%) of dendritically shaped, CD1a+/HLA-DR+++ cells. In addition to differences in their motility, the two dendritic cell populations generated differed from each other by the expression of LC-specific structures. Only the precursors expressing the skin homing receptor were found to differentiate into LC as evidenced by the presence of Birbeck granules. In contrast, CLA− precursor cells generated a CD1a+ DC population devoid of Birbeck granule–containing LC. Provided that comparable mechanisms as found in this study are also operative in vivo, we postulate that the topographic organization of the DC system is already determined, at least in part, at the progenitor level.

Strobl, H., E. Riedl, C. Scheinecker, C. Bello-Fernandez, W. F. Pickl, K. Rappersberger, O. Majdic y W. Knapp. "TGF-beta 1 promotes in vitro development of dendritic cells from CD34+ hemopoietic progenitors." Journal of Immunology 157, n.º 4 (15 de agosto de 1996): 1499–507. http://dx.doi.org/10.4049/jimmunol.157.4.1499.

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Abstract Several studies have demonstrated that dendritic cells (DC) can be generated in vitro from CD34+ hemopoietic progenitor cells. The growth requirements for these cells are poorly characterized, however. In particular, undefined serum/plasma components seem to significantly contribute to in vitro DC development. We report here that the cytokine combination granulocyte-macrophage CSF (GM-CSF) plus TNF-alpha and stem cell factor (SCF) commonly used for the in vitro generation of DC in serum/plasma-supplemented medium is, in the absence of serum supplementation, very inefficient in inducing DC development. We further demonstrate that supplementation with TGF-beta 1 is required for substantial DC development to occur in the absence of serum. Culture of CD34+ cells under serum-free conditions with TGF-beta 1 plus GM-CSF, TNF-alpha, and SCF strongly induces DC differentiation. This culture condition is even more efficient than culturing CD34+ cells with GM-CSF plus TNF-alpha and SCF in the presence of cord blood plasma. The proportions and total yields of cells with typical DC morphology and CD1a molecule expression are higher. The allostimulatory capacity of DC from TGF-beta 1-supplemented, cultures exceeds allostimulation by cells grown in plasma-containing medium. Substantial numbers (21 +/- 7%) of cells grown in TGF-beta 1-supplemented, but not plasma-supplemented, cultures express the Birbeck granule marker molecule Lag and display numerous Birbeck granules. Cells with distinct monocytic features are less frequently observed in TGF-beta 1-supplemented serum-free cultures. The addition of neutralizing anti-TGF-beta 1 Ab abrogates the observed TGF-beta 1 effects.

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Tesis sobre el tema "Granule de birbeck":

Hanau, Daniel. "Dynamique des marqueurs de la cellule de langerhans epidermique : vers une nouvelle comprehension du role du granule de birbeck". Université Louis Pasteur (Strasbourg) (1971-2008), 1987. http://www.theses.fr/1987STR13228.

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Hanau, Daniel. "Dynamique des marqueurs de la cellule de Langerhans épidermique vers une nouvelle compréhension du rôle du granule de Birbeck /". Grenoble 2 : ANRT, 1987. http://catalogue.bnf.fr/ark:/12148/cb37605793b.

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Behr-Gross, Esposito-Farese Marie-Emmanuelle. "Etude de la fonction de trois marqueurs des cellules de Langerhans épidermiqueS : le granule de Birbeck, les molécules CD1 et les récepteurs pour la partie Fc des immunoglobulines G". Strasbourg 1, 1995. http://www.theses.fr/1995STR15067.

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Uzan-Gafsou, Stéphanie. "Etude du rôle de Rab11 et de ses effecteurs dans l'homéostasie des granules de Birbeck des cellules de Langerhans". Paris 6, 2007. http://www.theses.fr/2007PA066519.

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Bien que le système endosomal des cellules eucaryotes ait été largement décrit, les mécanismes permettant la communication entre les différents compartiments, suscitent encore de nombreux débats. Or, les acteurs responsables de l’intégrité de ces compartiments ne sont pas distribués de façon aléatoire. Ces compartiments doivent donc être vus comme une combinaison unique et dynamique de sous-domaines membranaires fonctionnels. Au cours de ma thèse, je me suis intéressée aux mécanismes sous-jacents à la formation de ces sous-domaines. Mon travail a permis d’établir l’importance des protéines Rab dans la formation de ces microdomaines, grâce à l’étude de sous-domaines morphologiquement particuliers: les granules de Birbeck (BGs) des cellules de Langerhans. Bien que la Langerine ait été montrée comme un acteur indispensable dans la biogénèse de ces granules, la formation de ces structures ainsi que la stabilité même de la Langerine nécessitent aussi l’activité de Rab11A. Ce résultat nous a conduits à étudier le rôle des effecteurs de Rab11 dans ce contexte. Cette analyse a permis de mettre en évidence l’importance relative de différents complexes Rab11/effecteur sur la dynamique de la Langerine.

Chabrol, Eric. "Caractérisation structurale et fonctionnelle d'une lectine de type-C des cellules de Langerhans : La Langérine". Phd thesis, Université de Grenoble, 2012. http://tel.archives-ouvertes.fr/tel-00743636.

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Les cellules dendritiques jouent un rôle primordial dans le système immunitaire. En effet, ces cellules sont à l'interface entre l'immunité innée et adaptative par leur capacité de reconnaissance, d'internalisation et de dégradation de pathogènes afin de présenter des antigènes aux lymphocytes. La capacité de reconnaissance est engendrée par l'expression de différents récepteurs à la surface de ces cellules. Parmi ces récepteurs, deux grandes familles permettent la reconnaissance d'un large panel de différents pathogènes, comme les TLRs (" Toll-Like Receptors) et les lectines de type-C. Ces récepteurs sont utilisés comme marqueurs des différents sous-types de cellules dendritiques. Par exemple, parmi les lectines de type-C, DC-SIGN est majoritairement exprimée dans les cellules dendritiques dermiques alors que la Langérine est, quand à elle, fortement exprimée par les cellules dendritiques épidermiques, les cellules de Langerhans. Ces deux sous-types de cellules dendritiques divergent par leur réponse à l'infection par le VIH (" virus d'immunodéficience humain "). En effet, le virus utilise DC-SIGN pour détourner le rôle de ces cellules afin d'infecter les lymphocytes T alors que la reconnaissance du VIH par la Langérine, dans les cellules de Langerhans, conduit à la clairance de virus par son internalisation dans le granule de Birbeck. Cet organite est spécifique des cellules de Langerhans et nécessite l'expression de la Langérine. Ce travail de thèse s'est donc focalisé sur la caractérisation structurale et fonctionnelle de la Langérine. Il a permis de mettre en évidence l'importance de la structure tertiaire du domaine CRD et de la structure quaternaire de la protéine pour la formation et la bonne structuration du granule de Birbeck. Ensuite, l'étude fonctionnelle de cette lectine, notamment par résonance plasmonique de surface, nous a conduit à identifier une nouvelle spécificité de reconnaissance de la Langérine pour les glycosaminoglycanes dans un site d'interaction différent du site canonique. Enfin, nous avons caractérisé une spécificité de reconnaissance du site canonique pour les monosaccharides sulfatés de type glucosamine en utilisant la résonance plasmonique de surface et la cristallographie.

Capítulos de libros sobre el tema "Granule de birbeck":

Pavelka, Margit y Jürgen Roth. "Langerhans Cells and Birbeck Granules: Antigen Presenting Dendritic Cells of the Epidermis". En Functional Ultrastructure, 100–101. Vienna: Springer Vienna, 2010. http://dx.doi.org/10.1007/978-3-211-99390-3_52.

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"Birbeck Granule". En Encyclopedia of Cancer, 416. Berlin, Heidelberg: Springer Berlin Heidelberg, 2011. http://dx.doi.org/10.1007/978-3-642-16483-5_655.

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Webb, D. K. H. "Histiocytoses". En Oxford Textbook of Medicine, 4361–66. Oxford University Press, 2010. http://dx.doi.org/10.1093/med/9780199204854.003.220407.

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The histiocytoses are characterized by the infiltration of affected tissues with cells of monocyte/macrophage lineage. Langerhans’ cell histiocytosis—may present with (1) disease affecting a single organ—typically skin (rash) or bone (pain and soft tissue swelling, or asymptomatic radiographic lesions); or (2) multisystem disease—characteristic features include ear discharge, diabetes insipidus, and lung involvement (diffuse micronodular shadowing on chest radiography, with progression to cyst formation and a honeycomb lung appearance). Diagnosis requires identification of Langerhans’ cells within lesional inflammatory cell infiltrate, with demonstration of either the CD1a surface antigen on immunohistochemistry or the presence of Birbeck granules on electron microscopy. Most cases eventually resolve spontaneously. Immunosuppressive and/or cytotoxic drugs are given when there is progressive organ injury, but the most effective and least toxic approach to treatment is not known....