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Artículos de revistas sobre el tema "Heart Effect of drugs on"

Autor: Grafiati

Publicado: 4 de junio de 2021

Última modificación: 31 de enero de 2023

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1

Farrell, A. P., and M. S. Graham. "Effects of adrenergic drugs on the coronary circulation of Atlantic salmon (Salmo salar)." Canadian Journal of Zoology 64, no. 2 (February 1, 1986): 481–84. http://dx.doi.org/10.1139/z86-071.

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Spontaneously beating hearts from Atlantic salmon (Salmo salar) were used to examine the adrenergic regulation of the perfused coronary circulation. Excitatory α-adrenoceptors (vasoconstriction) dominated over inhibitory β-adrenoceptors (vasodilatation). Increased heart rate via β-adrenergic stimulation was possible with drug injections into the coronary artery. The heart rate effects followed the vasoactive effect by approximately 2 min.

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2

Rorabaugh, Boyd R., Sarah L. Seeley, Albert D. Bui, Lisanne Sprague, and Manoranjan S. D'Souza. "Prenatal methamphetamine differentially alters myocardial sensitivity to ischemic injury in male and female adult hearts." American Journal of Physiology-Heart and Circulatory Physiology 310, no. 4 (February 15, 2016): H516—H523. http://dx.doi.org/10.1152/ajpheart.00642.2015.

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Methamphetamine is one of the most common illicit drugs abused during pregnancy. The neurological effects of prenatal methamphetamine are well known. However, few studies have investigated the potential effects of prenatal methamphetamine on adult cardiovascular function. Previous work demonstrated that prenatal cocaine exposure increases sensitivity of the adult heart to ischemic injury. Methamphetamine and cocaine have different mechanisms of action, but both drugs exert their effects by increasing dopaminergic and adrenergic receptor stimulation. Thus the goal of this study was to determine

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3

Nordin, Henrik, Anders M. Galløe, Søren D. Ladefoged, and Jørn Badskjær. "The effects of propranolol and verapamil on hyperthyroid heart symptoms and function, assessed by systolic time intervals." Acta Endocrinologica 128, no. 4 (April 1993): 297–300. http://dx.doi.org/10.1530/acta.0.1280297.

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The effects of acute and chronic administration of propranolol and verapamil on heart rate and systolic time intervals were studied in 10 hyperthyroid patients and 10 normal subjects, both groups without signs of cardiovascular or pulmonary disease. In normal subjects iv propranolol reduced heart rate significantly, and both drugs increased the total electromechanical systole significantly without difference between the drugs. This effect was insignificant when the drugs were given orally. In hyperthyroid patients both drugs reduced heart rate significantly in acute and chronic administration,

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4

Haverkamp, W. "Heart rate effects of antimuscarinic drugs." International Urology and Nephrology 51, no. 10 (July 27, 2019): 1783–84. http://dx.doi.org/10.1007/s11255-019-02239-6.

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5

Frigy, Attila, Márta Germán-Salló, Lehel Máthé, and Mónika Szabó. "Vércukorcsökkentő gyógyszerek biztonságossága szívelégtelenségben." Orvosi Hetilap 158, no. 5 (February 2017): 163–71. http://dx.doi.org/10.1556/650.2017.30652.

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Abstract: The association of diabetes and heart failure is very common, furthermore, the pathophysiology and clinical course of the two entities have many crossing-points. Today, the spectrum of available anti-diabetic drugs is extremely wide, ranging from the classical (insulin, biguanides, sulphonylureas) to the most recent agents (gliptins, gliflozins). The cardiovascular effects of these drugs are multiple, their knowledge is important in the everyday practice, as the use of safe drugs regarding of heart failure is preferred. Our work provides an overview of each class of drugs after the p

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6

Bakhteev, R. R. "Effect of retabolil on hyperuricemia in chronic heart failure." Kazan medical journal 68, no. 2 (April 15, 1987): 102–3. http://dx.doi.org/10.17816/kazmj96023.

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Anabolic steroid drugs are widely used in the complex therapy of chronic heart failure. The positive effect of drugs of this group, in particular retabolol, is associated with the normalization of protein metabolism. Therefore, it is of interest to determine the possible effect of retabolol on purine metabolism as a component of protein metabolism, especially at the stage of uric acid formation. The development of hyperuricemic condition in heart failure against the background of treatment with cardiac glycosides and diuretics are reported by V. Е. Anisimov et al.

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7

Girouard, Catherine, Jean-Pierre Grégoire, Paul Poirier, and Jocelyne Moisan. "Effect of contraindicated drugs for heart failure on hospitalization among seniors with heart failure." Medicine 96, no. 9 (March 2017): e6239. http://dx.doi.org/10.1097/md.0000000000006239.

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8

Gatzov, Plamen. "New glucose-lowering drugs in patients with heart failure." Bulgarian Cardiology 27, no. 2 (July 21, 2021): 60–64. http://dx.doi.org/10.3897/bgcardio.27.e70144.

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The cardiovascular diseases are one of the main causes of mortality in the countries of Europe and North America. The heart failure (HF) and diabetes mellitus (DM) are widely spread diseases that become more frequent with the population aging in those regions. The algorithm of HF treatment in the last two decades includes several new medications. The SGLT-2 inhibitors (dapagliﬂ ozin, empagliﬂ ozin and canagloﬂ ozin) are new class anti diabetic medications which have positive effect on cardiovascular complications in patients with and without DB. The main trials using those medications in this

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9

Fehér, Gergely, and Gabriella Pusch. "Role of antihypertensive drugs in the treatment of migraine." Orvosi Hetilap 156, no. 5 (February 2015): 179–85. http://dx.doi.org/10.1556/oh.2015.30056.

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The treatment of migraine depends on the frequency, severity and concomitant diseases. There are several specific drugs developed for migraine prevention in addition to the additive antimigraine effects of some other non-specific drugs. The aim of this literature-based review is to summarize the possible antimigraine properties of different antihypertensive agents (beta-blockers, calcium channel blockers, angiotensin converting enzyme inhibitors, angiotensin receptor blockers, etc.) focusing on the possible side effects (avoidance of beta blockers in the absence of heart disease, possible anti

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10

Benfey, B. G. "Antifibrillatory effects of α1-adrenoceptor blocking drugs in experimental coronary artery occlusion and reperfusion". Canadian Journal of Physiology and Pharmacology 71, № 2 (1 лютого 1993): 103–11. http://dx.doi.org/10.1139/y93-015.

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The myocardium of animals and man possesses α1-adrenoceptors in addition to β-adrenoceptors. Ischemia increases sympathetic tone, and ventricular arrhythmias can occur by β- and α1-adrenoceptor stimulation. I believe that α1-adrenoceptor blocking drugs have antifibrillatory effects and will review the data that support this condition. The effect of α1,-adrenoceptor blocking drugs on the incidence of ventricular fibrillation in acute coronary artery occlusion and (or) reperfusion has been determined in 24 studies in conscious and anesthetized dogs and rats, anesthetized cats and pigs, and rat a

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11

Everett, S. D., G. M. Pantalos, I. F. Goldenberg, J. W. Long, P. D. Robison, R. K. White, M. S. Landa, W. J. Shaw, and D. B. Olsen. "Calves Chronically Implanted with a Total Artificial Heart as a Pharmacological Model." International Journal of Artificial Organs 14, no. 12 (December 1991): 775–80. http://dx.doi.org/10.1177/039139889101401206.

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Pharmacological therapy for congestive heart failure includes drugs that have both inotropic and vasoactive effects, although it is sometimes difficult to differentiate between the two effects. An animal with an implanted total artificial heart (TAH) allows the investigation of the vascular effect of these drugs in the absence of the effect on the myocardium. An advantage of the TAH model is its sensitivity to changes in right and left ventricular preload and afterload. Four instrumented TAH calves were given vasoactive drugs and the response was compared to control. Epinephrine, dopamine, iso

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12

Ahmed, Mohamed Mahmoud, Muhammad Abdel-Gawad, Mahmoud Ahmed Abd elbaset, and Assem Elkady. "Effect of Direct Acting Anti-Hepatitis C Drugs on the Heart." Egyptian Journal of Hospital Medicine 82, no. 1 (January 1, 2021): 106–14. http://dx.doi.org/10.21608/ejhm.2021.138116.

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13

Ritchie, Helen E., Isabelle Broström Huss, and William S. Webster. "The effect of anti-emetic drugs on rat embryonic heart activity." Reproductive Toxicology 87 (August 2019): 140–45. http://dx.doi.org/10.1016/j.reprotox.2019.06.002.

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14

Deschodt-Arsac, Véronique, Guillaume Calmettes, Gilles Gouspillou, Richard Rouland, Eric Thiaudiere, Sylvain Miraux, Jean-Michel Franconi, and Philippe Diolez. "System analysis of the effect of various drugs on cardiac contraction energetics." Biochemical Society Transactions 38, no. 5 (September 24, 2010): 1319–21. http://dx.doi.org/10.1042/bst0381319.

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We used MoCA (Modular Control and Regulation Analysis) to demonstrate in intact beating rat heart that physiological activation of contraction by adrenaline involves the almost perfect parallel activation of both mitochondria and myofibrils by intracellular Ca2+. This explains the perfect homoeostasis of the energetic intermediate PCr (phosphocreatine) in heart. When using drugs specifically stimulating either supply or demand activities, MoCA helped reveal the very specific mode of regulation of heart contraction energetics. Only activation of myofibrils activity (demand), either by increasin

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15

Baikalov, G. I., N. P. Leonov, P. G. Madonov, K. I. Ershov, K. I. Bakhareva, and M. S. Soldatova. "Chronotropic action of immobilized subtilisins during the perfusion of an isolated rat heart." Сибирский научный медицинский журнал 42, no. 5 (October 27, 2022): 37–42. http://dx.doi.org/10.18699/ssmj20220505.

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The pharmacological experiments on isolated organs (ex vivo) are the preferred method for assessing the primary pharmacodynamics of the studied drugs, since this method is completely excluded the systemic influence of neurohumoral regulation. In the last decade, a new group of thrombolytic drugs based on immobilized subtilisins has been formed. At the stage of registrational preclinical and clinical studies, their pleiotropic pharmacological effects have not been studied. Meanwhile, there is a reason to consider that their pharmacological activity in the bloodstream is not limited to thromboly

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16

AXELSSON, MICHAEL, ANTHONY P. FARRELL, and STEFAN NILSSON. "Effects of Hypoxia and Drugs on the Cardiovascular Dynamics of the Atlantic Hagfish Myxine Glutinosa." Journal of Experimental Biology 151, no. 1 (July 1, 1990): 297–316. http://dx.doi.org/10.1242/jeb.151.1.297.

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Cardiac output, ventral and dorsal aortic blood pressure and heart rate were recorded simultaneously in unanaesthetized hagfish, Myxine glutinosa L. Mean cardiac output was S.Tmlmin-1kg-1 and mean heart rate 22.3beatsmin-1. The absence of beat-to-beat oscillations in heart rate was consistent with the lack of an extrinsic cardiac innervation in hagfish. Mean blood pressures were 1.04 kPa (ventral aorta) and 0.77kPa (dorsal aorta). Injection of adrenaline into the caudal vein significantly increased cardiac output, stroke volume, heart rate and blood pressures of both aortas. Peak cardiac outpu

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17

Ostroumova, O. D., and I. V. Goloborodova. "Drug-Induced Heart Failure (Part 1: The Urgency of the Problem, the Prevalence, the Effect of Certain Groups of Drugs on the Risk of Development/Progression Heart Failure)." Safety and Risk of Pharmacotherapy 8, no. 1 (March 26, 2020): 23–35. http://dx.doi.org/10.30895/2312-7821-2020-8-1-23-35.

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Despite all the achievements of modern medicine, heart failure remains one of the most prevalent, severe and prognostically unfavorable conditions that requires close attention of the medical community. The diversity of the clinical picture and the large number of co-morbidities go hand in hand with a rather complicated pharmacotherapy regimen which, in the vast majority of cases, includes several medicines. Some classes of drugs can provoke the onset/progression of heart failure in patients with left ventricular dysfunction, as well as contribute to the development of heart failure in patient

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18

Chukaeva, I. I., N. V. Orlova, and M. V. Soloveva. "Rational therapy of hypertension with concomitant ischemic heart disease." Systemic Hypertension 11, no. 1 (March 15, 2014): 29–33. http://dx.doi.org/10.26442/sg29004.

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Hypertension is one of the most common cardiovascular diseases, that causes the disability and mortality. Recommendations of the European Society of Hypertension and the European Society of Cardiologyin 2013 identified new approaches of antihypertensive therapy. For the control of blood pressure is recommended five major groups of drugs. Numerous multicenter studies confirm the high efficiency of angiotensin converting enzyme inhibitors (perindopril) and calcium antagonists (amlodipine). Drugs have proven marked hypotensive and cardioprotective effects. Prestarium fixed combination with a calc

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19

Castro, Solange L. de, and Maria de Nazareth L. de Meirelles. "Effect of drugs on Trypanosoma cruzi and on its interaction with heart muscle cell in vitro." Memórias do Instituto Oswaldo Cruz 82, no. 2 (June 1987): 209–18. http://dx.doi.org/10.1590/s0074-02761987000200009.

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Megazol, nifurtimox, benznidazol and allopurinol were investigated, by light and electron µscopy, for their action on T. cruzi. Both the direct effect upon amastigote and trypomastigote forms and the effect upon the interaction of heart muscle cells (HMC) with bloodstream trypomastigotes were studied. The proliferation of amastigotes in Warren medium was inhibited in a dose-dependent manner by megazol, nifurtimox and benznidazol. Treatment of amastigotes (25-50 µM/24 h) and trypomastigotes (25 µM/24h) led to several ultrastructural alterations in the parasites. These three drugs also had a pot

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20

Król, Olgierd, Konrad Gładysz, Justyna Szydłowska, Olga Żuchnik, Piotr Kwiatkowski, Magdalena Czelej, Aleksander Kłos, Krzysztof Gieroba, Marcin Szydłowski, and Paweł Zuchniak. "SGLT-2 inhibitors: new effective drugs for treatment of heart failure." Journal of Education, Health and Sport 13, no. 2 (December 11, 2022): 55–61. http://dx.doi.org/10.12775/jehs.2023.13.02.007.

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Introduction: SGLT-2 inhibitors having selectivity to sodium glucose cotransporter 2 were introduced on the market in 2012 as drugs for the pharmacotherapy of type 2 diabetes.Aim of the work: To summarize the current state of knowledge about the drugs: SGLT-2 inhibitors and their mechanism of action and application in cardiology.Materials and Methods: A review of the literature available in PubMed and Google Scholar database was conducted.Results: In addition to glucosuria, the diuretic effect is caused by natriuresis. A study was conducted, after which it was deduced that the natriuretic effe

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21

Popova, Ekaterina P., O. T. Bogova, S. N. Puzin, I. S. Matsokin, A. A. Gadzhimagomedova, D. A. Sychev, and V. P. Fisenko. "INFLUENCE OF ANTIARRHYTHMIC DRUGS ON THE SPECTRAL ANALYSIS OF HEART RATE VARIABILITY IN PATIENTS WITH ATRIAL FIBRILLATION." Medical and Social Expert Evaluation and Rehabilitation 21, no. 1-2 (June 15, 2018): 101–4. http://dx.doi.org/10.18821/1560-9537-2018-21-1-101-104.

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The use of the spectral analysis of the heart rate variability to assess the effectiveness of therapy is of great attention of researchers and doctors. This method allows you to get knowledge of the influence of the autonomic nervous system on the heart activity, which is an important factor for the manifestation of the effects of antiarrhythmic drugs. In this study, we studied the effect of antiarrhythmic drugs of class III amiodarone and sotalol on spectral indices of the heart rate variability in patients with atrial fibrillation. The power of slow frequencies prevailed in the structure of

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22

Verdurmen, Kim M. J., Alexandra D. J. Hulsenboom, Judith O. E. H. van Laar, and S. Guid Oei. "Effect of tocolytic drugs on fetal heart rate variability: a systematic review." Journal of Maternal-Fetal & Neonatal Medicine 30, no. 20 (November 8, 2016): 2387–94. http://dx.doi.org/10.1080/14767058.2016.1249844.

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23

Zuanetti, Giulio, Roberto Latini, James M. M. Neilson, Peter J. Schwartz, and David J. Ewing. "Heart rate variability in patients with ventricular arrhythmias: Effect of antiarrhythmic drugs." Journal of the American College of Cardiology 17, no. 3 (March 1991): 604–12. http://dx.doi.org/10.1016/s0735-1097(10)80172-x.

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24

Cesana, F., C. Colombo, C. Valsecchi, M. Stucchi, P. Vallerio, A. Cereda, P. Meani, R. Ricotta, S. Siena, and C. Giannattasio. "P4.20 SHORT-TERM EFFECT OF ANTI-VEGF DRUGS ON HEART AND VESSELS." Artery Research 7, no. 3-4 (2013): 141. http://dx.doi.org/10.1016/j.artres.2013.10.138.

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25

Cohn, Jay N. "Role of drugs for systemic hypertension and their effect on the heart." American Journal of Cardiology 60, no. 12 (October 1987): G72—G74. http://dx.doi.org/10.1016/0002-9149(87)90595-9.

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26

Yepanchintseva, О. А., O. J. Zharinov, and І. V. Shklianka. "Effect of ranolazine on the course of ischemic heart disease after percutaneous coronary intervention." Cardiac Surgery and Interventional Cardiology, no. 4 (December 2020): 5–10. http://dx.doi.org/10.31928/2305-3127-2020.4.510.

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Optimization of antiischemic therapy is necessary in many patients with stable forms of coronary heart disease after or during revascularization. From the standpoint of current guidelines, the addition of second-line drugs, in particular ranolazine, to beta-blockers and/or calcium antagonists is considered during anginal attacks due to incomplete revascularization, to prevent myocardial damage during percutaneous coronary interventions, and in cases when revascularization is not possible. The results of many clinical studies have proven the antiischemic effect and safety of ranolazine after co

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27

Long, Ling, Hao-tian Zhao, Li-min Shen, Cong He, Shan Ren, and He-ling Zhao. "Hemodynamic effects of inotropic drugs in heart failure." Medicine 98, no. 47 (November 2019): e18144. http://dx.doi.org/10.1097/md.0000000000018144.

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28

Streeby, D. R., and T. A. McKean. "The effect of ATP-sensitive potassium channel modulation on heart rate in isolated muskrat and guinea pig hearts." Journal of Experimental Biology 197, no. 1 (December 1, 1994): 101–18. http://dx.doi.org/10.1242/jeb.197.1.101.

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Muskrats (Ondontra zibethicus) are common freshwater diving mammals exhibiting a bradycardia with both forced and voluntary diving. This bradycardia is mediated by vagal innervation; however, if hypoxia is present there may be local factors that also decrease heart rate. Some of these local factors may include ATP-sensitive potassium channel activation and extracellular accumulation of potassium ions, hydrogen ions and lactate. The purpose of this study was to investigate the role of these factors in the isolated perfused hearts of muskrats and of a non-diving mammal, the guinea pig. Although

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29

Abrar, Hina, M. Tariq Aftab, Hina Yasin, Kiran Qadeer, Adeel Arsalan, Hina Tabassum, and Rahila Bano. "Effect of Cardioselective Beta Blocker on Lisinopril Treated Isolated Rabbit’s Heart." RADS Journal of Pharmacy and Pharmaceutical Sciences 7, no. 4 (January 30, 2020): 186–90. http://dx.doi.org/10.37962/jpps.v7i4.341.

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Background: Certain drugs produce unpredictable responses when used in emergency conditions. These variable outcomes may be harmful or beneficial for the patient. Objective: This study has been conducted to evaluate the pharmacodynamic interaction between angiotensin converting enzyme inhibitor and metoprolol, a selective blocker of β1 receptors. Cardioselective beta blockers are commonly used to treat hypertension, arrhythmias and ischemic heart disease. Method: In this study, 20 healthy male rabbits were selected and divided into two groups. Effective dose of Lisinopril (10 mg/kg

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Novikova, D. S., H. V. Udachkina, I. G. Kirillova, and T. V. Popkova. "Chronic Heart Failure in Rheumatoid Arthritis Patients (Part III): Effects of Antirheumatic Drugs." Rational Pharmacotherapy in Cardiology 15, no. 6 (January 3, 2020): 820–30. http://dx.doi.org/10.20996/1819-6446-2019-15-6-820-830.

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Chronic autoimmune inflammation is one of the leading risk factors for the development of chronic heart failure (CHF) in rheumatoid arthritis (RA). The purpose of the review is to analyze the results of investigations on the effects of conventional synthetic disease-modifying anti-rheumatic drugs (csDMARDs), biological disease-modifying anti-rheumatic drugs (bDMARDs), and targeted csDMARDs on cardiac function and the risk of developing CHF in patients with RA. Methotrexate may reduce the CHF risk and have a positive effect on the course of this condition in patients with RA. Despite the data o

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31

Sobolev, Alexander V., Pavel G. Talabanov, Galina V. Ryabykina, Elena Sh Kozhemyakina, and Elena V. Oshchepkova. "New approaches to the analysis of daily variability of sinus rhythm in assessing the antihypertensive effect of various drugs." Systemic Hypertension 16, no. 4 (December 15, 2019): 70–79. http://dx.doi.org/10.26442/2075082x.2019.4.190730.

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Aim. Identify in patients with arterial hypertension (AH) the peculiarities of the effect of various classes of antihypertensive drugs on the daily variability of sinus rhythm (HRV). Material and methods. We examined 29 patients with grade 1-2 degree essential AH aged 32 to 60 years (16 men and 13 women) using bifunctional monitoring of ECG and blood pressure before and after treatment with bisoprolol, amlodipine, lisinopril and a combination consisting of lisinopril and amlodipine. We evaluated the hypotensive effect of the drugs associated with the distribution of heart rate during the day a

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Payudis, A. N., O. A. Efremova, L. A. Kamyshnikova, Iu S. Pavlova, O. V. Dudchenko, I. I. Khamnagadaev, and T. P. Golivets. "Effect of SGLT2 inhibitors on the course of chronic heart failure in patients with type 2 diabetes mellitus." Clinician 16, no. 2 (October 10, 2022): 10–16. http://dx.doi.org/10.17650/1818-8338-2022-16-2-k656.

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Diabetes mellitus (DM) is a group of metabolic diseases characterized by chronic hyperglycemia, which is the result of impaired insulin secretion, insulin action, or both. Chronic hyperglycemia in diabetes is accompanied by damage, dysfunction, and failure of various organs, especially the eyes, kidneys, nerves, heart, and blood vessels. Diabetes mellitus plays a significant role in the formation and is one of the significant risk factors for the development of chronic heart failure (CHF) through its glucose toxic effect, the effect on hyperlipidemia and blood coagulation, impaired autonomic r

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Sasaki, Takushi, Shunji Ueno, Yukio Hara, Tsuyoshi Uchide, and Kyosuke Temma. "Antimuscarinic action of doxorubicin does not involve free-radical formation in isolated guinea pig hearts." Canadian Journal of Physiology and Pharmacology 88, no. 1 (January 2010): 77–81. http://dx.doi.org/10.1139/y09-093.

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It has been proposed that the cardiotoxicity of anthracycline anticancer drugs involves free-radical formation. One early manifestation of toxicity appears to be caused by the antimuscarinic actions of these drugs. Accordingly, we examined whether the antimuscarinic action of one of these drugs, doxorubicin, is altered by antioxidants. In electrically stimulated left atrial muscle preparations obtained from guinea pig hearts, doxorubicin significantly increased the tissue concentration of thiobarbituric acid-reactive substance indicating increased lipid peroxidation. This effect of doxorubicin

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34

Vasovic, Velibor, Aleksandar Raskovic, Momir Mikov, Ivan Mikov, Boris Milijasevic, Sasa Vukmirovic, and Zorana Budakov. "Effect of aqueous solution of stevioside on pharmacological properties of some cardioactive drugs." Vojnosanitetski pregled 71, no. 7 (2014): 667–72. http://dx.doi.org/10.2298/vsp120524014v.

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Background/Aim. Stevioside is a glycoside that supposedly possesses a number of pharmacodynamic effects such as anti-infective, hypoglycemic, along with the beneficial influence on the cardiovascular system. The aim of this study was to determine the effect of rats pretreatment with aqueous solution of stevioside on pharmacological actions of adrenaline, metoprolol and verapamil. Methods. Rats were administered (intraperitoneally 200 mg/kg/day) stevioside as aqueous solution or physiological saline in the course of 5 days, then anaesthetized with urethane and the first ECG recording was made.

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35

Gorb, Yu G., S. A. Serik, O. V. Tkachenko, and V. V. Ryabukha. "Modern Approaches to Treatment of Chronic Heart Failure in Patients with Type 2 Diabetes Mellitus." Ukraïnsʹkij žurnal medicini, bìologìï ta sportu 7, no. 1 (March 22, 2022): 14–31. http://dx.doi.org/10.26693/jmbs07.01.014.

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The issues of epidemiology, pathophysiology and basic principles of treatment of chronic heart failure in patients with type 2 diabetes mellitus are considered. Attention is paid to both means of glycemic correction and treatment of chronic heart failure directly, taking into account the effectiveness, cardiovascular safety of drugs, as well as their impact on the course and prognosis of chronic heart failure. The results of randomized clinical trials to study the effectiveness of various groups of drugs for the treatment of chronic heart failure in patients with type 2 diabetes mellitus are p

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36

Govoruskina, Natalia, Vladimir Jakovljevic, Vladimir Zivkovic, Isidora Milosavljevic, Jovana Jeremic, Jovana Bradic, Sergey Bolevich, et al. "The Role of Cardiac N-Methyl-D-Aspartate Receptors in Heart Conditioning—Effects on Heart Function and Oxidative Stress." Biomolecules 10, no. 7 (July 16, 2020): 1065. http://dx.doi.org/10.3390/biom10071065.

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As well as the most known role of N-methyl-D-aspartate receptors (NMDARs) in the nervous system, there is a plethora of evidence that NMDARs are also present in the cardiovascular system where they participate in various physiological processes, as well as pathological conditions. The aim of this study was to assess the effects of preconditioning and postconditioning of isolated rat heart with NMDAR agonists and antagonists on heart function and release of oxidative stress biomarkers. The hearts of male Wistar albino rats were subjected to global ischemia for 20 min, followed by 30 min of repe

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Kundu, Aman, and Gyanesh Singh. "Dopamine synergizes with caffeine to increase the heart rate of Daphnia." F1000Research 7 (March 1, 2018): 254. http://dx.doi.org/10.12688/f1000research.12180.1.

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Dopamine is a key neurotransmitter, and is widely used as a central nervous system (CNS) agent. Dopamine plays an important role in humans, including a major role in reward and motivation behaviour. Several addictive drugs are well known to increase neuronal dopamine activity. We selected Daphnia, an important model organism, to investigate the effect(s) of selected CNS agents on heart rate. Dopamine’s effects on Daphnia’s heart has not been previously reported. Caffeine is a well-known and widely consumed stimulant. Ethanol is well known for its effects on both neurological and physiological

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38

Syroid, Noah D., James Agutter, Frank A. Drews, Dwayne R. Westenskow, Robert W. Albert, Julio C. Bermudez, David L. Strayer, Hauke Prenzel, Robert G. Loeb, and Matthew B. Weinger. "Development and Evaluation of a Graphical Anesthesia Drug Display." Anesthesiology 96, no. 3 (March 1, 2002): 565–75. http://dx.doi.org/10.1097/00000542-200203000-00010.

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Background Usable real-time displays of intravenous anesthetic concentrations and effects could significantly enhance intraoperative clinical decision-making. Pharmacokinetic models are available to estimate past, present, and future drug effect-site concentrations, and pharmacodynamic models are available to predict the drug's associated physiologic effects. Methods An interdisciplinary research team (bioengineering, architecture, anesthesiology, computer engineering, and cognitive psychology) developed a graphic display that presents the real-time effect-site concentrations, normalized to th

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39

HANANO, Masaharu, Akira HATTORI, Tomoko KOJIMA, Tohru IZUMI, Tomio TAKESHIGE, Shinichiro TAKIZAWA, Ichiro FUSE, et al. "Effect of antiplatelet drugs in patients with prosthetic heart valves under warfarin treatment." Blood & Vessel 19, no. 1 (1988): 26–33. http://dx.doi.org/10.2491/jjsth1970.19.26.

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40

Wändell, Per, Axel C. Carlsson, Jan Sundquist, Sven-Erik Johansson, Matteo Bottai, and Kristina Sundquist. "Effect of cardiovascular drugs on mortality in atrial fibrillation and chronic heart failure." Scandinavian Cardiovascular Journal 48, no. 5 (August 6, 2014): 291–98. http://dx.doi.org/10.3109/14017431.2014.941002.

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41

Sun, Jiahao, Hongcai Shang, Xiaochen Yang, and Yanwei Xing. "Effect of Cardioprotective Drugs on Chemotherapy-Induced Heart Failure and New Risk Stratification." Journal of the American College of Cardiology 74, no. 13 (October 2019): 1736. http://dx.doi.org/10.1016/j.jacc.2019.07.050.

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42

Bezrukov, Vladislav, Liana Kuprush, Nina Sykalo, Tetyana Panteleymonova, Ludmila Sharabura, and Vitaliy Olar. "Effect of ATP and molsidomine combination on contractile function of isolated adult and old rat hearts during adequate coronary perfusion, at ischemia and reperfusion." Ageing & Longevity, no. 2 (July 7, 2021): 8–17. http://dx.doi.org/10.47855/jal9020-2021-2-2.

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Abstract. Pathology of the cardiovascular system occupies a major place in the structure of diseases of the elderly and old patients. Metabolic disturbances are very important in ischemic damages of myocardium in the elderly and old people. So, drugі with metabolic mechanism of action is very ppromising in the treatment of elderly patients with cardiovascular diseases. The relevance of this study is determined by the feasibility of using drugs of metabolic action, which have a beneficial effect on the metabolism of cardiomyocytes, improve blood supply to the myocardium, increase its contractil

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43

Erichev, V. P., та A. S. Makarova. "Сompatibility of Systemic Drugs and Local Antihypertensive Therapy in Patients with Primary Open-Angle Glaucoma (Analytical Review)". Ophthalmology in Russia 15, № 4 (9 січня 2019): 366–73. http://dx.doi.org/10.18008/1816-5095-2018-4-366-373.

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The review presents data of the most common comorbid diseases in patients with primary open-angle glaucoma, the features of local and general influence of antiglaucoma drugs, as well as information about the possible drug interactions of local antihypertensive and systemic medicines. Local antihypertensive drugs are often embedded in the daily patients regimen of systemic drugs use. Up to80 % of the active substances in ophthalmic drugs are absorbed systemically, while not subject to the primary stages of metabolism. Anti-glaucoma drugs can cause serious side effects: symptomatic bradycardia,

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44

Pinho-Gomes, A. C. P., L. Azevedo, Z. Bidel, M. Nazarzadeh, D. Canoy, E. Copland, A. Salam, A. Rodgers, D. Kotecha, and K. Rahimi. "EFFECTS OF BLOOD PRESSURE LOWERING DRUGS IN HEART FAILURE." Journal of Hypertension 37 (July 2019): e56. http://dx.doi.org/10.1097/01.hjh.0000570916.49054.88.

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45

Pinho-Gomes, Ana-Catarina, Luis Azevedo, Zeinab Bidel, Milad Nazarzadeh, Dexter Canoy, Emma Copland, Abdul Salam, Anthony Rodgers, Dipak Kotecha, and Kazem Rahimi. "Effects of blood pressure-lowering drugs in heart failure." Journal of Hypertension 37, no. 9 (September 2019): 1757–67. http://dx.doi.org/10.1097/hjh.0000000000002094.

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46

Kobayashi, H., T. Sano, R. C. Tarazi, and F. M. Fouad-Tarazi. "Effects of antihypertensive drugs on heart and resistance vessels." Cardiovascular Research 24, no. 2 (February 1, 1990): 137–43. http://dx.doi.org/10.1093/cvr/24.2.137.

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47

Dood, Kenneth P., Aaron D. Frey, and Timothy P. Geisbuhler. "The Effect of Hawthorn Extract on Coronary Flow." Journal of Evidence-Based Complementary & Alternative Medicine 18, no. 4 (June 13, 2013): 257–67. http://dx.doi.org/10.1177/2156587213491428.

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Hawthorn extract has been used for heart failure and may decrease cardiac cell injury and improve cardiac function. One proposed mechanism for hawthorn action is vasodilation. We hypothesized that hawthorn extract would increase coronary blood flow in isolated perfused rat hearts. Coronary flow was measured in nonworking perfused rat hearts (Langendorff, constant pressure) using a flow probe; data were collected electronically in real time. Hawthorn extract showed an early (30-120 seconds) vasodilation, followed by a later (3-5 minutes) decrease in coronary flow. Maximum vasodilation occurred

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Kockova, Radka, Jarmila Svatunkova, Jiri Novotny, Lucie Hejnova, Bohuslav Ostadal, and David Sedmera. "Heart rate changes mediate the embryotoxic effect of antiarrhythmic drugs in the chick embryo." American Journal of Physiology-Heart and Circulatory Physiology 304, no. 6 (March 15, 2013): H895—H902. http://dx.doi.org/10.1152/ajpheart.00679.2012.

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A significant increase in cardiovascular medication use during pregnancy occurred in recent years. Only limited evidence on safety profiles is available, and little is known about the mechanisms of adverse effect on the fetus. We hypothesized that drug-induced bradycardia is the leading mechanism of developmental toxicity. Embryotoxicity was tested in ovo after administration of various doses of metoprolol, carvedilol, or ivabradine. Embryonic day (ED) 4 and 8 chick embryos were studied by video microscopy and ultrasound biomicroscopy ex ovo after intraamniotic injection of the drug for a peri

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Hanigan, Sarah, and Robert J. DiDomenico. "Emerging Therapies for Acute and Chronic Heart Failure." Journal of Pharmacy Practice 29, no. 1 (January 11, 2016): 46–57. http://dx.doi.org/10.1177/1933719115615877.

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Although the period from 1953 to 2001 resulted in the approval of more than 30 medications currently used to treat heart failure (HF), few novel drugs have been approved in the last decade. However, the investigational pipeline for HF medications once again appears promising. In patients with chronic heart failure with reduced ejection fraction (HFrEF), ivabradine and valsartan/sucubitril (LCZ696) were recently approved by the US Food and Drug Administration. Both agents have been shown to reduce the risk of cardiovascular death and HF hospitalization. In the treatment of acute HF, serelaxin a

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50

Popova, E. P., S. S. Puzin, O. T. Bogova, S. N. Puzin, D. A. Sychev, and V. P. Fisenko. "Effect of Amiodarone, Sotalol and Bisoprolol on Heart Rate Variability in Patients with Atrial Fibrillation." Rational Pharmacotherapy in Cardiology 16, no. 5 (November 4, 2020): 721–29. http://dx.doi.org/10.20996/1819-6446-2020-10-07.

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Aim. To study the effect of class III antiarrhythmic drugs (amiodarone and sotalol), and the β-blocker bisoprolol on the spectral parameters of heart rate variability in patients with different forms of atrial fibrillation (AF).Material and methods. Spectral analysis of heart rate variability of 5-minute electrocardiography intervals was used. The study included patients with newly diagnosed AF and having a duration of the disease from 6 months to 8 years. Arterial hypertension, coronary artery disease, myocardial infarction (in history), conduction disorders and type 2 diabetes mellitus were

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