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Tesis sobre el tema "Heart Metabolism"

Autor: Grafiati

Publicado: 4 de junio de 2021

Última modificación: 11 de febrero de 2022

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1

Murray, Andrew James. "Control of cardiac metabolism and efficiency." Thesis, University of Oxford, 2003. http://ora.ox.ac.uk/objects/uuid:858cc1f9-7ba0-4999-a1c8-614a950888c2.

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2

Babić, Nikolina. "Regulation of energy metabolism of heart myoblasts /." Thesis, Connect to this title online; UW restricted, 2004. http://hdl.handle.net/1773/11563.

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3

Belke, Darrell David. "Hypothermia and energy substrate metabolism in the heart." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1997. http://www.collectionscanada.ca/obj/s4/f2/dsk3/ftp04/nq21548.pdf.

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4

Råmunddal, Truls Are. "Myocardial metabolism in experimental infarction and heart failure /." Göteborg : Department of Molecular and Clinical Medicine, The Wallenberg Laboratory for Cardiovascular Research, Sahlgrenska Academy Göteborg University, 2008. http://hdl.handle.net/2077/9565.

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5

Heather, Lisa Claire. "Substrate transporters and metabolism in the hypertrophied heart." Thesis, University of Oxford, 2007. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.442468.

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6

Beadle, Roger. "Metabolic manipulation in chronic heart failure." Thesis, University of Aberdeen, 2013. http://digitool.abdn.ac.uk:80/webclient/DeliveryManager?pid=201651.

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Treatments aimed at modifying cardiac substrate utilisation are designed to improve metabolic efficiency. In the fasting state, the heart mainly relies on fatty acid oxidation for its energy production. The heart can adapt to metabolise glucose, lactate and amino acids depending on the predominate milieu and demands placed upon it. A shift from fatty acid oxidation to carbohydrate oxidation leads to a lower oxygen consumption per unit of adenosine triphosphate produced. It is this concept of improving cardiac efficiency by a reduction in oxygen demand that underpins the use of metabolic manipu

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7

Adix, Longlet Nancy J. "Chronic Ventricular Sympathectomy : Effects on Myocardial Metabolism." Thesis, University of North Texas, 1993. https://digital.library.unt.edu/ark:/67531/metadc278768/.

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Chronic ventricular sympathectomy elicits changes in the coronary circulation, myocardial oxygen consumption and size of infarction resulting fromcoronary occlusion. These changes indicate a change occurring in the basic metabolism of the heart in response to the removal of its sympathetic nervous input. This hypothesis was tested using two groups of dogs, a shamoperated control and a ventricular sympathectomized group. The sympathectomy procedure was an intrapericardial surgical technique which selectively removes ventricular sympathetic input. Four weeks after surgery, left ventricular tissu

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8

Jones, Barney. "Ischaemia and efficiency in the isolated heart." Thesis, University of Oxford, 2000. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.311982.

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9

Lindbom, Malin. "Myocardial creatine metabolism in experimental infarction and heart failure /." Göteborg : Dept. of Molecular and Clinical Medicine/Cardiology, Wallenberg Laboratory for Cardiovascular research, Sahlgrenska Academy, Göteborgs Universitet, 2007. http://hdl.handle.net/2077/7380.

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10

Kalsi, Kameljit Kaur. "Nucleotide and adenosine metabolism in heart failure and cardioprotection." Thesis, Imperial College London, 2003. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.409176.

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11

Turner, J. E. "Collagen metabolism in normal heart and during cardiac hypertrophy." Thesis, Imperial College London, 1988. http://hdl.handle.net/10044/1/47290.

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12

Keon, Claudia Anne. "Myocardial energy transduction in the isolated working rat heart." Thesis, University of Oxford, 1997. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.244563.

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13

Tien, Pamela. "Reductive metabolism of aliphatic tertiary amine n-oxides." Thesis, De Montfort University, 1999. http://hdl.handle.net/2086/10714.

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This study is based on a proposal concerning the feasibility of using aliphatic tertiary amine N-oxides as antiarrhythmic agent prodrugs. Lignocaine was selected as a candidate for prodrug development, because the N-oxide is a non-active, polar derivative of lignocaine and the drug of choice for ventricular arrhythmia, a symptom associated with ischaemic episodes leading to regions of transiently hypoxic heart tissue. An HPLC analytical method was developed to study the metabolism of lignocaine N-oxide. The rapid and sensitive analysis of lignocaine and its metabolites was demonstrated with go

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14

Álvarez, Guardia David. "Estudi dels mecanismes moleculars implicats en l’associació entre inflamació i alteracions metabòliques en cèl∙lules cardíaques." Doctoral thesis, Universitat de Barcelona, 2011. http://hdl.handle.net/10803/31985.

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El canvi en l’estil de vida que s’ha produït en les societats desenvolupades els darrers anys ha tingut com a contrapartida l’aparició de conductes sedentàries i modificacions en la dieta. Com a conseqüència d’aquests factors s’han produït diverses alteracions metabòliques que han causat un augment de la prevalença de l’obesitat. Aquesta obesitat té una sèrie d’efectes adversos sobre la fisiologia cardiovascular i és considerada un important factor de risc pel desenvolupament de la insuficiència cardíaca. De fet, el consum de dietes amb un elevat contingut en greixos (HFD) s’ha relacionat amb

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15

Piepoli, Massimo F. "Cardiovascular and ventilatory responses to exercise in chronic heart failure." Thesis, Imperial College London, 1996. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.243516.

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16

Jackson, Kim Geraldine. "Acute and chronic effects of monounsaturated fatty acid intake on chylomicron metabolism." Thesis, University of Surrey, 1997. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.360952.

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17

Hopkins, James Charles Alex. "Myocardial glycogen, glucose uptake and insulin sensitivity : interrelations and changes with disease." Thesis, University of Oxford, 1997. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.363766.

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18

Kreshel, Leigh Anne. "Increasing energy expenditure of cardiac rehabilitation patients." Electronic thesis, 2002. http://dspace.zsr.wfu.edu/jspui/handle/10339/175.

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19

Erol, Erdal. "Heart- and liver-type fatty acid binding proteins in lipid and glucose metabolism." Diss., Texas A&M University, 2004. http://hdl.handle.net/1969.1/1148.

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Heart-type Fatty Acid-Binding Protein (H-FABP) is required for high rates of skeletal muscle long chain fatty acid (LCFA) oxidation and esterification. Here we assessed whether H-FABP affects soleus muscle glucose uptake when measured in vitro in the absence of LCFA. Wild type and H-FABP null mice were fed a standard chow or high fat diet before muscle isolation. With the chow, the mutation increased insulin-dependent deoxyglucose uptake by 141% (P<0.01) at 0.02 mU/ml of insulin, but did not cause a significant effect at 2 mU/ml insulin; skeletal muscle triglyceride and long chain acyl-CoA (LC

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20

Ponce, Jessica Marie. "Investigating the roles of cyclin C in the mammalian heart." Diss., University of Iowa, 2019. https://ir.uiowa.edu/etd/7015.

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Although pathological alterations in gene expression and mitochondria function in response to cardiac ischemia are well recognized, the mechanisms driving these changes are incompletely understood. Nuclear to mitochondrial communication regulating gene expression and mitochondrial function is a critical process following cardiac ischemic injury. Here we determine that cyclin C, a component of the transcriptional regulator, Mediator complex, directly regulates cardiac and mitochondrial function by modifying mitochondrial fission. We tested the hypothesis that cyclin C has a binary function as a

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21

Costa, Eunice Cristina da Silva. "Glicogenio cardiaco em diabetes experimental : efeitos do tratamento com metformina e/ou glibenclamida sobre as funções cardiacas em coração isolado." [s.n.], 2005. http://repositorio.unicamp.br/jspui/handle/REPOSIP/313912.

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Orientador: Antonio Ari Gonçalves<br>Tese (doutorado) - Universidade Estadual de Campinas, Instituto de Biologia<br>Made available in DSpace on 2018-08-04T15:30:30Z (GMT). No. of bitstreams: 1 Costa_EuniceCristinadaSilva_D.pdf: 2678840 bytes, checksum: 439eb1d320bc5d4828c77cb0e086e763 (MD5) Previous issue date: 2005<br>Resumo: Objetivos: Metformina e glibenclamida são fármacos utilizados para diminuir a glicemia de diabéticos tipo 2. Metformina reduz a absorção gastrintestinal de glicose e a gliconeogênese hepática e aumenta a captação de glicose periférica. Por sua vez, glibenclamida aument

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22

Steeples, Violetta Rae. "Metabolic modulation through deletion of hypoxia-inducible factor-1α and fumarate hydratase in the heart". Thesis, University of Oxford, 2015. http://ora.ox.ac.uk/objects/uuid:f546ca24-6226-4846-b492-30de26836e94.

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Hypoxia inducible factor-1α (HIF-1α) plays a critical role in the oxygen homeostasis of all metazoans. HIF-1α is a master transcriptional regulator which coordinates the adaptive response to low oxygen tension. Through activation of a plethora of downstream target genes, HIF-1α facilitates oxygenation by promoting angiogenesis and blood vessel dilation, in addition to modulating metabolic pathways to inhibit oxidative phosphorylation and promote glycolytic energy production. Given the critical roles of hypoxia, insufficient blood supply and perturbed energetics in the p

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23

Morgan, Eric E. "The Cardiac Fatty Acid Metabolic Pathway in Heart Failure." Case Western Reserve University School of Graduate Studies / OhioLINK, 2006. http://rave.ohiolink.edu/etdc/view?acc_num=case1138394643.

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24

Dormans-Linssen, Maria Caroline Jacqueline Gerarda. "Cells of adult rat heart isolation, characterization and some aspects of fatty acid metabolism /." Maastricht : Maastricht : Universitaire Pers Maastricht ; University Library, Maastricht University [Host], 1993. http://arno.unimaas.nl/show.cgi?fid=5959.

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25

Wu, Joe. "HIF-1α in the Heart: Provision of Ischemic Cardioprotection and Remodeling of Nucleotide Metabolism". Digital Commons @ East Tennessee State University, 2014. https://dc.etsu.edu/etd/2450.

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In our studies we found that stabilized expression of HIF-1α in heart led to better recovery of function and less tissue death after 30 minutes of global ischemia, via mechanisms that preserve the mitochondrial polarization. Our group previously showed that HIF-1α conferred ischemic tolerance by allowing cardiomyocytes to use fumarate as an alternative terminal electron acceptor to sustain anaerobic mitochondrial polarization. The source of fumarate was identified as the purine nucleotide cycle (PNC). Here we discovered that HIF-1α upregulates AMP deaminase 2 (AMPD2), the entry point to the PN

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26

Mansor, Latt Shahril. "Effect of hypoxia on cardiac metabolism and function in the type 2 diabetic heart." Thesis, University of Oxford, 2015. https://ora.ox.ac.uk/objects/uuid:e84a3068-0c7d-46d7-a37f-3433cc06b3d4.

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Type 2 diabetic patients have impaired cardiac ischaemia-reperfusion recovery and higher rates of mortality following a myocardial infarction. Hypoxia is a key component of ischaemia and therefore, this thesis is aimed to investigate the effect of hypoxia on metabolism and contractile function of the type 2 diabetic heart. In combination with high fat feeding, different doses of streptozotocin (STZ) (15, 20, 25 and 30 mg/kg) were used to determine the optimal dose needed for induction of diabetes in male Wistar rats. A novel type 2 diabetic model was developed and characterised by hyperinsulin

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27

Whitman, Samantha. "Fragile X Related Protein-1 (FXR1) Regulates RNA Metabolism in Striated Muscle." Diss., The University of Arizona, 2011. http://hdl.handle.net/10150/195153.

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Cardiac muscle function necessitates the meticulous assembly and interactions of several cytoskeletal and regulatory proteins into specialized structures that orchestrate contraction and transmission forces. Despite extensive studies identifying the protein components responsible for these important aspects of heart development, putative RNA based mechanisms remain poorly understood, even with their demonstrated importance in other tissues. Evidence suggests that post-transcriptional regulation is critical for muscle function, but the molecular players involved (RNA binding proteins and mRNA t

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28

Bursill, Christina. "Green tea and its catechins modulate cholesterol metabolism in cultured human liver (HepG2) cells and the hypercholesterolaemic rabbit." Title page, contents and introduction only, 2000. http://web4.library.adelaide.edu.au/theses/09PH/09pdb9725.pdf.

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Includes bibliographical references (21 leaves). Previous studies have found that green tea and its antitoxidant constituents, the catechins, are hypocholesterolaemic in both epidemiological and animal intervetion studies. The main objectives of the present study were to investigate the mechanism by which green tea and its most abundant catechin constituent epigallocatechin gallate increase the low-density lipoprotein (LDL) receptor of HepG2 cells. In addition, it was hoped to determine if a crude catechin extract from green tea could lower plasma cholesterol levels in the hypercholesterolaemi

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29

Palácio, Manoel Angelo Gomes. "Glicemia na ressuscitação cardiopulmonar." Universidade de São Paulo, 2011. http://www.teses.usp.br/teses/disponiveis/98/98131/tde-06102011-075431/.

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Hiperglicemia está associada a mal prognóstico nas doenças crônicas e agudas, mas poucos estudos abordaram a glicemia durante a ressuscitação cardiopulmonar. Objetivo: Avaliar a evolução da glicemia em modelo de parada cardíaca similar ao atendimento atual dos casos de morte súbita extra-hospitalar. Métodos: Em estudo prospectivo, randomizado e cego, fibrilação ventricular foi induzida em 32 animais. Após 7 min, suporte de vida padrão foi iniciado e mantido até o retorno da circulação espontânea ou por 30 min no máximo. Os animais foram randomizados em três grupos, de acordo com o fármaco apli

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30

Lage, Jéssica. "Frequência cardíaca, lactato, custo líquido de transporte e energia metabólica de equinos de marcha batida ou picada da raça Mangalarga Marchador /." Jaboticabal, 2016. http://hdl.handle.net/11449/143447.

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Orientador: Guilherme de Camargo Ferraz<br>Marcos Jun Watanabe<br>José Corrêa de Lacerda Neto<br>Resumo: Objetivou-se caracterizar a frequência cardíaca máxima (FCMÁX), a intensidade da prova de marcha oficial e comparar o custo de transporte (COT) e a energia metabólica (P) de equinos da raça Mangalarga Marchador (MM) de marcha picada (MP) ou batida (MB). Ao todo 22 equinos da raça MM participaram deste estudo. O experimento foi realizado em três fases: 1) teste de esforço máximo (TEM), 2) provas oficiais de marcha (POM) e 3) teste padronizado de marcha (TMP). Para caracterizar a FCMÁX, 19 eq

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31

Wallin, Mats. "The GH/IGF-1 system during surgery and catabolism : focus on metabolism and heart function /." Stockholm, 2007. http://diss.kib.ki.se/2007/978-91-7357-418-1/.

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32

Johnson, Andrew William. "Metabolic control of energetics in human heart and skeletal muscle." Thesis, University of Oxford, 2012. http://ora.ox.ac.uk/objects/uuid:82c0dce6-a162-4c08-b061-3ea7f2e35134.

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Myocardial and skeletal muscle high energy phosphate metabolism is abnormal in heart failure, but the pathophysiology is not understood. Plasma non-esterified fatty acids (NEFA) increase in heart failure due to increased sympathetic drive, and regulate the transcription of mitochondrial uncoupling protein-3 (UCP3), through peroxisome proliferator-activated receptor-α. The aim of the work in this thesis was to determine whether cardiac PCr/ATP ratios and skeletal muscle PCr kinetics during exercise were related to cardiac and skeletal muscle UCP3 levels respectively, thus providing a mechanism

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33

Gasparini, Isabella. "Cardiorespiratory responses upon increased metabolism in the Ornate Tinamou, Nothoprocta ornata." Thesis, Linköpings universitet, Biologi, 2012. http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-81900.

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The Bolivian Ornate Tinamou, Nothoprocta ornata, lives higher than 3300 m above sea level and must constantly deal with a restricted availability of atmospheric oxygen, i.e., chronic hypoxia. Interestingly enough, the Ornate Tinamou has a small heart to body ratio, which implies a reduced ability in transporting oxygenated blood to the tissues. In order to increase knowledge about the cardiorespiratory response of the Ornate Tinamou, heart rate (HR) and ventilation frequency (VR) were monitored during resting at 25 °C. The values were compared with those obtained in conditions known to elevate

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34

陈美翩 and Meipian Chen. "Effects of iron overload on apoptosis and titin proteolysis in cardiomyocytes." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2013. http://hdl.handle.net/10722/193425.

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Iron is one of the essential elements involved in various fundamental biological activities. However, excess iron may bypass the negative feedback regulatory systems, leading to the formation of iron overload. The increase of iron deposition generates cellular toxicity and subsequently damages vital organs. Primary and secondary iron overload are affecting patients worldwide. Iron overload cardiomyopathy is the primary cause of cardiac dysfunction and cardiovascular mortality in β-thalassaemia major patients. Current effective therapy includes chelation treatment with conventional and new iron

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35

Imbriolo, Jamie. "Increased flux through the hexosamine biosynthetic pathway leads to the induction of acetol-CoA caboxylase gene expression in the heart." Thesis, Stellenbosch : Stellenbosch University, 2008. http://hdl.handle.net/10019.1/21459.

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Thesis (MSc)--Stellenbosch University, 2008.<br>ENGLISH ABSTRACT: Gene expression of the cardiac isoform of acetyl-CoA carboxylase (ACCb) is induced in a glucose-dependent manner. ACCb produces malonyl-CoA, a potent inhibitor of mitochondrial fatty acid uptake. Previous studies show that increased flux through the hexosamine biosynthetic pathway (HBP) under hyperglycaemic conditions may contribute to the development of insulin resistance. In light of this, we hypothesised that increased HBP flux induces cardiac ACCb gene expression thereby contributing to the onset of insulin resistance.

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36

Faller, Kiterie Maud Edwige. "Application of magnetic resonance for non-invasive phenotyping of mice with altered metabolism." Thesis, University of Oxford, 2011. http://ora.ox.ac.uk/objects/uuid:73d1b728-b9e5-41fa-999f-30025b70d25e.

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Changes in myocardial energetics have been implicated in the pathophysiology of heart failure (HF). However, the precise contribution of creatine (Cr) / phosphocreatine (PCr) / creatine kinase (CK) energy buffer and transfer remains unclear. The aim of this thesis was to study the effects on murine cardiac function of both impairment and enhancement of creatine metabolism. In order to longitudinally follow the cause and effect relationship of myocardial creatine concentration, a non-invasive method of quantification was required. Cardiac Cr levels measured in vivo by 1H-MRS were therefore comp

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37

Winter, James. "The linking of angiogenesis to contractile performance and substrate metabolism in the hypertrophied and failing heart." Thesis, University of Birmingham, 2010. http://etheses.bham.ac.uk//id/eprint/1025/.

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It has been suggested that a failure of angiogenesis (capillary growth) to keep pace with myocyte expansion is the driving force which pushes hypertrophied hearts into a state of failure marked by contractile dysfunction and alterations in the mechanisms governing energy production. The aims of this study were to investigate how alterations in ventricular capillarity affect contractile performance and substrate metabolism in the isolated rat heart. It was hypothesised that, if cardiac contractile performance and substrate utilisation are directly related to ventricular capillarity then methods

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38

Wilson, Heather Marion. "High density lipoprotein subspecies and the control of lipoprotein metabolism in relation to coronary heart disease." Thesis, University of Aberdeen, 1990. http://digitool.abdn.ac.uk/R?func=search-advanced-go&find_code1=WSN&request1=AAIU031961.

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The concept that high plasma concentrations of high density lipoproteins (HDL) offers protection against coronary heart disease has been challenged on epidemiological grounds. This dispute may arise as a result of the heterogeneous nature of HDL in which only some subspecies exert a protective function while the major portion has a neutral role. In order to test this hypothesis, the distribution of HDL subfractions in 100 myocardial infarction (MI) survivors was examined within 12 hours of the onset of chest pain and before post-MI changes in lipoproteins occurred. These patients were shown to

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39

Slingo, Mary Elizabeth. "The role of the hypoxia-inducible pathway in metabolism and cardiopulmonary physiology." Thesis, University of Oxford, 2013. http://ora.ox.ac.uk/objects/uuid:f674808e-6731-49e9-b838-1032875a2ced.

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The research in this thesis investigated the role of the hypoxia-inducible factor (HIF) family of transcription factors in metabolism and cardiopulmonary physiology. Specifically, the effects of HIF on ventilatory control, carotid body morphology, and cardiac metabolism and function were studied using a murine model of a genetic disorder of oxygen sensing known as Chuvash polycythaemia. HIF coordinates oxygen-regulated gene expression throughout all organ systems, thereby orchestrating cellular, tissue and systemic responses to hypoxia. HIF is primarily regulated by oxygen-dependent prolyl hyd

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40

Vánky, Farkas. "Surgery for aortic stenosis : with special reference to myocardial metabolism, postoperative heart failure and long-term outcome /." Linköping : Linköpings universitet, 2006. http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-7471.

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41

Okuda, Junji. "Persistent Overexpression of Phosphoglycerate Mutase, a Glycolytic Enzyme, Modifies Energy Metabolism and Reduces Stress Resistance of Heart in Mice." Kyoto University, 2014. http://hdl.handle.net/2433/185197.

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42

Beauchamp, Brittany. "Low Birth Weight is Associated with Impaired Skeletal and Cardiac Muscle Energetics in Adult Mice." Thesis, Université d'Ottawa / University of Ottawa, 2015. http://hdl.handle.net/10393/32963.

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In utero undernutrition is associated with increased risk for insulin resistance, obesity, and cardiovascular disease during adult life. A common phenotype associated with low birth weight is reduced skeletal muscle mass. Given the central role of skeletal muscle in whole body metabolism, we hypothesized that predisposition to metabolic disease is, in part, due to low oxidative capacity and dysfunctional mitochondrial energetics in muscle. We used an experimental mouse model system of maternal undernutrition during late pregnancy to examine female offspring from undernourished dams (U) and con

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43

Dodd, Michael S. "The development and application of new hyperpolarized magnetic resonance spectroscopy techniques for the non-invasive assessment of metabolism in the rodent heart." Thesis, University of Oxford, 2012. http://ora.ox.ac.uk/objects/uuid:153b884e-b6dc-482e-bc48-7e6b9a457bbd.

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The aim of this thesis was to develop and apply new hyperpolarized magnetic resonance spectroscopy techniques, to assess in vivo metabolism in the rodent heart. Initial work using rat models of heart disease has provided key findings, such as significant increases in pyruvate dehydrogenase flux in the hypertensive rat heart and metabolic alterations in the TCA cycle during the progression into heart failure. Both could provide future non-invasive markers for the metabolic alterations associated with hypertrophy and heart failure in patients. Whilst both of these models provided useful informat

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44

Warner, Anke Sigrid. "The expression, regulation and effects of inducible nitric oxide synthase in hibernating myocardium." Title page, contents and summary only, 2002. http://web4.library.adelaide.edu.au/theses/09PH/09phw279.pdf.

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Amendments inserted at back. "May 2002" Includes bibliographical references (leaves 237-290) Experiments described in this thesis address the potential role of inducible nitric oxide synthase (iNOS) in hibernating myocardium. Specifically it was sought to establish a cellular model of hibernating myocardium and investigate the expression, regulation and effects of iNOS in this model. Experiments were performed using primary cultures of neonatal rat ventricular myocytes.

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45

Dane-Stewart, Cheryl Ann. "Postprandial lipoprotein metabolism in patients at high risk of coronary artery disease : effects of statin therapy." University of Western Australia. School of Medicine and Pharmacology, 2003. http://theses.library.uwa.edu.au/adt-WU2004.0061.

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[Formulae and special characters can only be approximated here. Please see the pdf version of the abstract for an accurate reproduction.] Atherosclerosis is a common degenerative disease in which the clinical manifestations are often through stroke or myocardial infarction. Some of the established risk factors for atherosclerosis include elevated plasma low-density lipoprotein (LDL)-cholesterol levels, obesity, diabetes mellitus (DM) and cigarette smoking. Of the risk factors, an elevation in plasma LDL is one of the most established and the most researched. This is partly a consequence of

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46

Vánky, Farkas. "Surgery for aortic stenosis : with special reference to myocardial metabolism, postoperative heart failure and long-term outcome." Doctoral thesis, Linköpings universitet, Thoraxkirurgi, 2006. http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-7471.

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Postoperative heart failure (PHF) remains a major determinant of the outcome after cardiac surgery. However, characteristics of and risk factors for PHF after valve surgery have received little attention. Post-ischaemic disturbances of myocardial metabolism that may contribute to PHF and are amenable to metabolic treatment have been identified early after coronary surgery (CABG). Knowledge derived from these studies may not be applicable to other patient groups. We therefore studied myocardial energy metabolism in 20 elective patients undergoing aortic valve replacement (AVR) for isolated aort

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47

Patel, Brinda. "The purification and metabolism of a mitochondrial high phosphate derivative oligophosphoglyceroyl-ATP, in rat heart and liver." Thesis, University College London (University of London), 1992. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.261193.

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48

Mahmod, Masliza. "Multiparametric cardiovascular magnetic resonance for the assessment of cardiac function and metabolism in hypertrophy and heart failure." Thesis, University of Oxford, 2013. http://ora.ox.ac.uk/objects/uuid:ff24c167-e00d-4c6d-9809-82203979ba7a.

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Both hypertrophied and failing hearts are characterised by pathological left ventricular (LV) remodelling, impaired myocardial energy status and alteration in substrate metabolism. Cardiac magnetic resonance imaging (CMR) and magnetic resonance spectroscopy (MRS) are powerful tools in the characterisation of these disease conditions. More recent techniques have allowed assessment of myocardial steatosis using <sup>1</sup>H-MRS and tissue oxygenation using blood oxygen level dependent (BOLD) CMR. In hypertrophy and heart failure, studies on steatosis and the relationship with other parameters s

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49

Wild, Sarah Helen. "Mortality and morbidity from coronary heart disease, diabetes and hypertension in women with polycystic ovary syndrome at long-term follow-up." Thesis, London School of Hygiene and Tropical Medicine (University of London), 2000. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.367837.

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50

Miller, Isabelle Sarton. "Estimation of energy expenditure in children : a simple and non-invasive approach using heart rate and regression modelling /." Thesis, Connect to this title online; UW restricted, 2005. http://hdl.handle.net/1773/6455.

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