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Artículos de revistas sobre el tema "Hélice polyproline de type II"

Autor: Grafiati

Publicado: 30 de noviembre de 2024

Última modificación: 31 de julio de 2025

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1

Zagrovic, B., J. Lipfert, E. J. Sorin, et al. "Unusual compactness of a polyproline type II structure." Proceedings of the National Academy of Sciences 102, no. 33 (2005): 11698–703. http://dx.doi.org/10.1073/pnas.0409693102.

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2

van Holst, G. J., S. R. Martin, A. K. Allen, D. Ashford, N. N. Desai, and A. Neuberger. "Protein conformation of potato (Solanum tuberosum) lectin determined by circular dichroism." Biochemical Journal 233, no. 3 (1986): 731–36. http://dx.doi.org/10.1042/bj2330731.

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The structure of potato (Solanum tuberosum) lectin, which is a hydroxyproline-rich glycoprotein, has been investigated by circular dichroism. The spectra of the native lectin, and of the oxidized, reduced and carboxymethylated and deglycosylated derivatives were examined, as was a hydroxyproline-rich glycopeptide and its deglycosylated derivative. It is concluded that the lectin contains about 35% polyproline II conformation, 34% type II beta-turn and 31% irregular conformation. No indications were found for the presence of alpha-helix or beta-sheet conformations. The polyproline II conformati

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3

Kubyshkin, Vladimir, and Nediljko Budisa. "Construction of a polyproline structure with hydrophobic exterior using octahydroindole-2-carboxylic acid." Organic & Biomolecular Chemistry 15, no. 3 (2017): 619–27. http://dx.doi.org/10.1039/c6ob02306a.

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4

Lam, Sik Lok, and Victor L. Hsu. "NMR identification of left-handed polyproline type II helices." Biopolymers 69, no. 2 (2003): 270–81. http://dx.doi.org/10.1002/bip.10354.

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5

Song, Jikui, Jered V. McGivern, Karl W. Nichols, John L. Markley, and Michael D. Sheets. "Structural basis for RNA recognition by a type II poly(A)-binding protein." Proceedings of the National Academy of Sciences 105, no. 40 (2008): 15317–22. http://dx.doi.org/10.1073/pnas.0801274105.

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We identified a functional domain (XlePABP2-TRP) of Xenopus laevis embryonic type II poly(A)-binding protein (XlePABP2). The NMR structure of XlePABP2-TRP revealed that the protein is a homodimer formed by the antiparallel association of β-strands from the single RNA recognition motif (RRM) domain of each subunit. In each subunit of the homodimer, the canonical RNA recognition site is occluded by a polyproline motif. Upon poly(A) binding, XlePABP2-TRP undergoes a dimer-monomer transition that removes the polyproline motif from the RNA recognition site and allows it to be replaced by the adenos

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6

Vlasov, Peter K., Anna V. Vlasova, Vladimir G. Tumanyan, and Natalia G. Esipova. "A tetrapeptide-based method for polyproline II-type secondary structure prediction." Proteins: Structure, Function, and Bioinformatics 61, no. 4 (2005): 763–68. http://dx.doi.org/10.1002/prot.20670.

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7

Doose, S., H. Neuweiler, H. Barsch, and M. Sauer. "Probing polyproline structure and dynamics by photoinduced electron transfer provides evidence for deviations from a regular polyproline type II helix." Proceedings of the National Academy of Sciences 104, no. 44 (2007): 17400–17405. http://dx.doi.org/10.1073/pnas.0705605104.

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8

Srinivasan, Mythily, and A. Keith Dunker. "Proline Rich Motifs as Drug Targets in Immune Mediated Disorders." International Journal of Peptides 2012 (May 16, 2012): 1–14. http://dx.doi.org/10.1155/2012/634769.

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The current version of the human immunome network consists of nearly 1400 interactions involving approximately 600 proteins. Intermolecular interactions mediated by proline-rich motifs (PRMs) are observed in many facets of the immune response. The proline-rich regions are known to preferentially adopt a polyproline type II helical conformation, an extended structure that facilitates transient intermolecular interactions such as signal transduction, antigen recognition, cell-cell communication and cytoskeletal organization. The propensity of both the side chain and the backbone carbonyls of the

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9

Vlasov, P. K., A. V. Budzko, M. A. Rubin, V. G. Tumanyan, A. A. Makarov, and N. G. Esipova. "Left-handed helix of polyproline ii type in linker regions of DNA-binding proteins." Biophysics 53, no. 6 (2008): 663–64. http://dx.doi.org/10.1134/s0006350908060353.

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10

Mazuryk, Jarosław, Izabela Puchalska, Kamil Koziński, et al. "PTD4 Peptide Increases Neural Viability in an In Vitro Model of Acute Ischemic Stroke." International Journal of Molecular Sciences 22, no. 11 (2021): 6086. http://dx.doi.org/10.3390/ijms22116086.

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Ischemic stroke is a disturbance in cerebral blood flow caused by brain tissue ischemia and hypoxia. We optimized a multifactorial in vitro model of acute ischemic stroke using rat primary neural cultures. This model was exploited to investigate the pro-viable activity of cell-penetrating peptides: arginine-rich Tat(49–57)-NH2 (R49KKRRQRRR57-amide) and its less basic analogue, PTD4 (Y47ARAAARQARA57-amide). Our model included glucose deprivation, oxidative stress, lactic acidosis, and excitotoxicity. Neurotoxicity of these peptides was excluded below a concentration of 50 μm, and PTD4-induced p

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11

Siermala, Markku, Martti Juhola, and Mauno Vihinen. "On preprocessing of protein sequences for neural network prediction of polyproline type II secondary structures." Computers in Biology and Medicine 31, no. 5 (2001): 385–98. http://dx.doi.org/10.1016/s0010-4825(01)00013-0.

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12

Schweitzer-Stenner, Reinhard, Bridget Milorey, and Harald Schwalbe. "Randomizing of Oligopeptide Conformations by Nearest Neighbor Interactions between Amino Acid Residues." Biomolecules 12, no. 5 (2022): 684. http://dx.doi.org/10.3390/biom12050684.

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Flory’s random coil model assumes that conformational fluctuations of amino acid residues in unfolded poly(oligo)peptides and proteins are uncorrelated (isolated pair hypothesis, IPH). This implies that conformational energies, entropies and solvation free energies are all additive. Nearly 25 years ago, analyses of coil libraries cast some doubt on this notion, in that they revealed that aromatic, but also β-branched side chains, could change the 3J(HNHCα) coupling of their neighbors. Since then, multiple bioinformatical, computational and experimental studies have revealed that conformational

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13

Feng, Chuang, Zhen Wang, Guokun Li, Xiaohan Yang, Nannan Wu, and Lei Wang. "BERT-PPII: The Polyproline Type II Helix Structure Prediction Model Based on BERT and Multichannel CNN." BioMed Research International 2022 (August 24, 2022): 1–14. http://dx.doi.org/10.1155/2022/9015123.

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Predicting the polyproline type II (PPII) helix structure is crucial important in many research areas, such as the protein folding mechanisms, the drug targets, and the protein functions. However, many existing PPII helix prediction algorithms encode the protein sequence information in a single way, which causes the insufficient learning of protein sequence feature information. To improve the protein sequence encoding performance, this paper proposes a BERT-based PPII helix structure prediction algorithm (BERT-PPII), which learns the protein sequence information based on the BERT model. The BE

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14

Pilpel, Yair, Oren Bogin, Vlad Brumfeld, and Ziv Reich. "Polyproline Type II Conformation in the C-Terminal Domain of the Nuclear Pore Complex Protein gp210†." Biochemistry 42, no. 12 (2003): 3519–26. http://dx.doi.org/10.1021/bi0266176.

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15

Cutini, Michele, Marta Corno, Dominique Costa, and Piero Ugliengo. "How Does Collagen Adsorb on Hydroxyapatite? Insights From Ab Initio Simulations on a Polyproline Type II Model." Journal of Physical Chemistry C 123, no. 13 (2017): 7540–50. http://dx.doi.org/10.1021/acs.jpcc.7b10013.

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16

Perczel, András, Ödön Farkas, Imre G. Csizmadia, and Attila G. Császar. "Peptide models XX. Aromatic side-chain–backbone interaction in phenylalanine-containing diamide model system. A systematic search for the identification of all the ab initio conformers of N-formyl-L-phenylalanine-amide." Canadian Journal of Chemistry 75, no. 8 (1997): 1120–30. http://dx.doi.org/10.1139/v97-134.

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Phenylalanine is the simplest among the four natural amino acid residues that have aromatic side chains. The ab initio conformational analysis performed at the RHF/3-21G level on a phenylalanine-containing diamide model system (N-Formyl-L-Phe-NH2) revealed 19 different structures. Single-point energy calculations were performed using RHF/6-31+G* and DFT(B3LYP)/6-311++G** levels for all conformers. The inverse (γL) and the normal (γD) gamma turn, the extended (βL), the left-handed helical [Formula: see text], and the inverse polyproline II [Formula: see text] backbone conformers each have three

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17

Renugopalakrishnan, V., L. A. Carreira, T. W. Collette, J. C. Dobbs, G. Chandraksasan, and R. C. Lord. "Non-Uniform Triple Helical Structure in Chick Skin Type I Collagen on Thermal Denaturation: Raman Spectroscopic Study." Zeitschrift für Naturforschung C 53, no. 5-6 (1998): 383–88. http://dx.doi.org/10.1515/znc-1998-5-613.

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The individual chains in the triple helix of collagen occur in a conformation related to polyproline II because of the presence of large number of imino peptide bonds. However, these residues are not evenly distributed in the collagen molecule which also contains many non-imino residues. These non-imino regions of collagen may be expected to show preference for other than triple helical conformations. The appearance of several Raman bands in solution phase at 65 °C raises the possibility of non-uniform triple helical structure in collagen. Raman spectroscopic studies on collagen in the solid s

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18

Siermala, M., M. Juhola, and M. Vihinen. "On Postprocessing of Neural Network Prediction of Polyproline Type II Secondary Structures: Network Spectrum, Response Analysis, and Scattering." Neural Computing & Applications 11, no. 3-4 (2003): 238–43. http://dx.doi.org/10.1007/s00521-003-0360-5.

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19

Reuter, Cédric, Robert Opitz, Arne Soicke, et al. "Design and Stereoselective Synthesis of ProM-2: A Spirocyclic Diproline Mimetic with Polyproline Type II (PPII) Helix Conformation." Chemistry - A European Journal 21, no. 23 (2015): 8464–70. http://dx.doi.org/10.1002/chem.201406493.

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20

Pazderková, Markéta, Eva Kočišová, Tomáš Pazderka, et al. "Antimicrobial Peptide from the Eusocial BeeHalictus sexcinctusInteracting with Model Membranes." Spectroscopy: An International Journal 27 (2012): 497–502. http://dx.doi.org/10.1155/2012/840956.

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Halictine-1 (Hal-1)—a linear antibacterial dodecapeptide isolated from the venom of the eusocial beeHalictus sexcinctus—has been subjected to a detailed spectroscopic study including circular dichroism, fluorescence, and vibrational spectroscopy. We investigated Hal-1 ability to adopt an amphipathicα-helical structure upon interaction with model lipid-based bacterial membranes (phosphatidylcholine/phosphatidylglycerol-based large unilamellar vesicles and sodium dodecylsulfate micelles) and helix inducing components (trifluoroethanol). It was found that Hal-1 responds sensitively to the composi

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21

Alte, F., A. Stengel, J. P. Benz, et al. "Ferredoxin:NADPH oxidoreductase is recruited to thylakoids by binding to a polyproline type II helix in a pH-dependent manner." Proceedings of the National Academy of Sciences 107, no. 45 (2010): 19260–65. http://dx.doi.org/10.1073/pnas.1009124107.

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22

Ishijima, J., N. Nagasaki, M. Maeshima, and M. Miyano. "RVCaB, a Calcium-binding Protein in Radish Vacuoles, is Predominantly an Unstructured Protein with a Polyproline Type II Helix." Journal of Biochemistry 142, no. 2 (2007): 201–11. http://dx.doi.org/10.1093/jb/mvm130.

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23

Bhagwanth, Swapna, Ram K. Mishra, and Rodney L. Johnson. "Development of peptidomimetic ligands of Pro-Leu-Gly-NH2 as allosteric modulators of the dopamine D2 receptor." Beilstein Journal of Organic Chemistry 9 (January 30, 2013): 204–14. http://dx.doi.org/10.3762/bjoc.9.24.

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A variety of stable, small-molecule peptidomimetic ligands have been developed to elucidate the mechanism by which the neuropeptide Pro-Leu-Gly-NH2 (PLG) modulates dopaminergic neurotransmission. Photoaffinity labeling ligands based upon PLG peptidomimetics have been used to establish that PLG binds to the D2 dopamine receptor at a site that is different from the orthosteric site, thus making PLG and its peptidomimetics allosteric modulators of the dopamine receptor. Through the design, synthesis and pharmacological evaluation of conformationally constrained peptidomimetics containing lactam,

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24

Scholl, Connor L., Sakae Tsuda, Laurie A. Graham, and Peter L. Davies. "Crystal waters on the nine polyproline type II helical bundle springtail antifreeze protein from Granisotoma rainieri match the ice lattice." FEBS Journal 288, no. 14 (2021): 4332–47. http://dx.doi.org/10.1111/febs.15717.

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25

Esipova, N. G., L. E. Ragulina, L. I. Davydova та ін. "Left helix of polyproline II type and genesis of β-structures in spidroins 1 and 2 and their recombinant analogs". Biophysics 54, № 3 (2009): 271–74. http://dx.doi.org/10.1134/s0006350909030014.

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26

Reuter, Cédric, Peter Huy, Jörg-Martin Neudörfl, Ronald Kühne, and Hans-Günther Schmalz. "Exercises in Pyrrolidine Chemistry: Gram Scale Synthesis of a Pro-Pro Dipeptide Mimetic with a Polyproline Type II Helix Conformation." Chemistry - A European Journal 17, no. 43 (2011): 12037–44. http://dx.doi.org/10.1002/chem.201101704.

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27

Meirson, Tomer, David Bomze, Gal Markel та Abraham O. Samson. "κ-helix and the helical lock and key model: a pivotal way of looking at polyproline II". Bioinformatics 36, № 12 (2020): 3726–32. http://dx.doi.org/10.1093/bioinformatics/btaa186.

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Abstract Motivation Polyproline II (PPII) is a common conformation, comparable to α-helix and β-sheet. PPII, recently termed with a more generic name—κ-helix, adopts a left-handed structure with 3-fold rotational symmetry. Lately, a new type of binding mechanism—the helical lock and key model was introduced in SH3-domain complexes, where the interaction is characterized by a sliding helical pattern. However, whether this binding mechanism is unique only to SH3 domains is unreported. Results Here, we show that the helical binding pattern is a universal feature of the κ-helix conformation, prese

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28

MacDougall, Lindsay K., Mary Elizabeth Gagou, Sally J. Leevers, Ernst Hafen, and Michael D. Waterfield. "Targeted Expression of the Class II Phosphoinositide 3-Kinase in Drosophila melanogaster Reveals Lipid Kinase-Dependent Effects on Patterning and Interactions with Receptor Signaling Pathways." Molecular and Cellular Biology 24, no. 2 (2004): 796–808. http://dx.doi.org/10.1128/mcb.24.2.796-808.2004.

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ABSTRACT Phosphoinositide 3-kinases (PI3Ks) can be divided into three distinct classes (I, II, and III) on the basis of their domain structures and the lipid signals that they generate. Functions have been assigned to the class I and class III enzymes but have not been established for the class II PI3Ks. We have obtained the first evidence for a biological function for a class II PI3K by expressing this enzyme during Drosophila melanogaster development and by using deficiencies that remove the endogenous gene. Wild-type and catalytically inactive PI3K_68D transgenes have opposite effects on th

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29

Raghavan, Bhooma, Kevin J. Skoblenick, Swapna Bhagwanth, Niran Argintaru, Ram K. Mishra та Rodney L. Johnson. "Allosteric Modulation of the Dopamine D2Receptor by Pro-Leu-Gly-NH2Peptidomimetics Constrained in Either a Polyproline II Helix or a Type II β-Turn Conformation". Journal of Medicinal Chemistry 52, № 7 (2009): 2043–51. http://dx.doi.org/10.1021/jm801575w.

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30

Bhatnagar, Rajendra S., Mark B. Shattuck, Jing Jing Qian, Craig A. Gough, and Steven B. Nicoll. "Theoretical and Experimental Approaches to Identification of a Fiber Surface Cell Binding Domain in Collagen and its Application in Tissue Engineering." Microscopy and Microanalysis 6, S2 (2000): 986–87. http://dx.doi.org/10.1017/s1431927600037429.

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Type I collagen comprises between 75-95% of the stationary extracellular matrix of most tissues, forming a continuum in which most of the static cells are anchored. Collagen serves as the track for haptotactic cell migration. The junction between collagen, its receptor integrins, and the cells’ cytoskeleton plays a crucial role in cell differentiation and morphogenesis by serving as the agent for transducing mechanical forces into chemical and biochemical work. The physiological, functional organization of collagen is the solid state in the form of a network of fibers. The only molecules avail

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31

Gautam, Gunjan, Syed Arif Abdul Rehman, Preeti Pandey, and Samudrala Gourinath. "Crystal structure of the PEG-bound SH3 domain of myosin IB fromEntamoeba histolyticareveals its mode of ligand recognition." Acta Crystallographica Section D Structural Biology 73, no. 8 (2017): 672–82. http://dx.doi.org/10.1107/s2059798317009639.

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The versatility in the recognition of various interacting proteins by the SH3 domain drives a variety of cellular functions. Here, the crystal structure of the C-terminal SH3 domain of myosin IB fromEntamoeba histolytica(EhMySH3) is reported at a resolution of 1.7 Å in native and PEG-bound states. Comparisons with other structures indicated that the PEG molecules occupy protein–protein interaction pockets similar to those occupied by the peptides in other peptide-bound SH3-domain structures. Also, analysis of the PEG-boundEhMySH3 structure led to the recognition of two additional pockets, apar

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32

Beausoleil, Eric, and William D. Lubell. "An examination of the steric effects of 5-tert-butylproline on the conformation of polyproline and the cooperative nature of type II to type I helical interconversion." Biopolymers 53, no. 3 (2000): 249–56. http://dx.doi.org/10.1002/(sici)1097-0282(200003)53:3<249::aid-bip4>3.0.co;2-j.

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33

Rowińska-Żyrek, Magdalena, Anna Wiȩch, Joanna Wa̧tły, et al. "Copper(II)-Binding Induces a Unique Polyproline Type II Helical Structure within the Ion-Binding Segment in the Intrinsically Disordered F-Domain of Ecdysteroid Receptor from Aedes aegypti." Inorganic Chemistry 58, no. 17 (2019): 11782–92. http://dx.doi.org/10.1021/acs.inorgchem.9b01826.

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34

Srinivasan, Mythily, Richard M. Wardrop, Ingrid E. Gienapp, Scott S. Stuckman, Caroline C. Whitacre, and Pravin T. P. Kaumaya. "A Retro-Inverso Peptide Mimic of CD28 Encompassing the MYPPPY Motif Adopts a Polyproline Type II Helix and Inhibits Encephalitogenic T Cells In Vitro." Journal of Immunology 167, no. 1 (2001): 578–85. http://dx.doi.org/10.4049/jimmunol.167.1.578.

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35

Brown, Alaina M., and Neal J. Zondlo. "A Propensity Scale for Type II Polyproline Helices (PPII): Aromatic Amino Acids in Proline-Rich Sequences Strongly Disfavor PPII Due to Proline–Aromatic Interactions." Biochemistry 51, no. 25 (2012): 5041–51. http://dx.doi.org/10.1021/bi3002924.

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36

Ahmed, Shubbir, Anshuman Shukla та Purnananda Guptasarma. "Folding behavior of a backbone-reversed protein: Reversible polyproline type II to β-sheet thermal transitions in retro-GroES multimers with GroES-like features". Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics 1784, № 6 (2008): 916–23. http://dx.doi.org/10.1016/j.bbapap.2008.02.009.

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37

Batkhishig, Dashdavaa, Khurelbaatar Bilguun, Purevjav Enkhbayar, Hiroki Miyashita, Robert H. Kretsinger та Norio Matsushima. "Super Secondary Structure Consisting of a Polyproline II Helix and a β-Turn in Leucine Rich Repeats in Bacterial Type III Secretion System Effectors". Protein Journal 37, № 3 (2018): 223–36. http://dx.doi.org/10.1007/s10930-018-9767-9.

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38

Kurz, E. M., T. W. Holstein, B. M. Petri, J. Engel, and C. N. David. "Mini-collagens in hydra nematocytes." Journal of Cell Biology 115, no. 4 (1991): 1159–69. http://dx.doi.org/10.1083/jcb.115.4.1159.

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We have isolated and characterized four collagen-related c-DNA clones (N-COL 1, N-COL 2, N-COL 3, N-COL 4) that are highly expressed in developing nematocytes in hydra. All four c-DNAs as well as their corresponding transcripts are small in size (600-1,000 bp). The deduced amino acid sequences show that they contain a central region consisting of 14 to 16 Gly-X-Y triplets. This region is flanked amino-terminal by a stretch of 14-23 proline residues and carboxy-terminal by a stretch of 6-9 prolines. At the NH2- and COOH-termini are repeated patterns of cysteine residues that are highly conserve

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39

Caporale, Andrea, Simone Adorinni, Doriano Lamba, and Michele Saviano. "Peptide–Protein Interactions: From Drug Design to Supramolecular Biomaterials." Molecules 26, no. 5 (2021): 1219. http://dx.doi.org/10.3390/molecules26051219.

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The self-recognition and self-assembly of biomolecules are spontaneous processes that occur in Nature and allow the formation of ordered structures, at the nanoscale or even at the macroscale, under thermodynamic and kinetic equilibrium as a consequence of specific and local interactions. In particular, peptides and peptidomimetics play an elected role, as they may allow a rational approach to elucidate biological mechanisms to develop new drugs, biomaterials, catalysts, or semiconductors. The forces that rule self-recognition and self-assembly processes are weak interactions, such as hydrogen

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40

Top, Deniz, Jolene A. Read, Sandra J. Dawe, Raymond T. Syvitski, and Roy Duncan. "Cell-Cell Membrane Fusion Induced by p15 Fusion-associated Small Transmembrane (FAST) Protein Requires a Novel Fusion Peptide Motif Containing a Myristoylated Polyproline Type II Helix." Journal of Biological Chemistry 287, no. 5 (2011): 3403–14. http://dx.doi.org/10.1074/jbc.m111.305268.

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41

Adolph, Dörte, Nadine Flach, Katharina Mueller, Dirk H. Ostareck, and Antje Ostareck-Lederer. "Deciphering the Cross Talk between hnRNP K and c-Src: the c-Src Activation Domain in hnRNP K Is Distinct from a Second Interaction Site." Molecular and Cellular Biology 27, no. 5 (2006): 1758–70. http://dx.doi.org/10.1128/mcb.02014-06.

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ABSTRACT The protein tyrosine kinase c-Src is regulated by two intramolecular interactions. The repressed state is achieved through the interaction of the Src homology 2 (SH2) domain with the phosphorylated C-terminal tail and the association of the SH3 domain with a polyproline type II helix formed by the linker region between SH2 and the kinase domain. hnRNP K, the founding member of the KH domain protein family, is involved in chromatin remodeling, regulation of transcription, and translation of specific mRNAs and is a target in different signal transduction pathways. In particular, it func

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42

Stoddart, Cheryl A., Romas Geleziunas, Sharon Ferrell, et al. "Human Immunodeficiency Virus Type 1 Nef-Mediated Downregulation of CD4 Correlates with Nef Enhancement of Viral Pathogenesis." Journal of Virology 77, no. 3 (2003): 2124–33. http://dx.doi.org/10.1128/jvi.77.3.2124-2133.2003.

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ABSTRACT The nef gene products encoded by human immunodeficiency virus type 1 (HIV-1) and simian immunodeficiency virus type 1 (SIV-1) increase viral loads in infected hosts and accelerate clinical progression to AIDS. Nef exhibits a spectrum of biological activities, including the ability to downregulate surface expression of CD4 and major histocompatibility complex (MHC) class I antigens, to alter the state of T-cell activation, and to enhance the infectivity of viral particles. To determine which of these in vitro functions most closely correlates with the pathogenic effects of Nef in vivo,

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43

Nobuhisa, Ikuo, Ryu Takeya, Kenji Ogura та ін. "Activation of the superoxide-producing phagocyte NADPH oxidase requires co-operation between the tandem SH3 domains of p47phox in recognition of a polyproline type II helix and an adjacent α-helix of p22phox". Biochemical Journal 396, № 1 (2006): 183–92. http://dx.doi.org/10.1042/bj20051899.

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Activation of the superoxide-producing phagocyte NADPH oxidase, crucial for host defence, requires an SH3 (Src homology 3)-domain-mediated interaction of the regulatory protein p47phox with p22phox, a subunit of the oxidase catalytic core flavocytochrome b558. Although previous analysis of a crystal structure has demonstrated that the tandem SH3 domains of p47phox sandwich a short PRR (proline-rich region) of p22phox (amino acids 151–160), containing a polyproline II helix, it has remained unknown whether this model is indeed functional in activation of the oxidase. In the present paper we sho

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Mucha, Piotr, Emilia Sikorska, Piotr Rekowski, and Jarosław Ruczyński. "Interaction of Arginine-Rich Cell-Penetrating Peptides with an Artificial Neuronal Membrane." Cells 11, no. 10 (2022): 1638. http://dx.doi.org/10.3390/cells11101638.

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Arginine-rich cell-penetrating peptides (RRCPPs) exhibit intrinsic neuroprotective effects on neurons injured by acute ischemic stroke. Conformational properties, interaction, and the ability to penetrate the neural membrane are critical for the neuroprotective effects of RRCCPs. In this study, we applied circular dichroism (CD) spectroscopy and coarse-grained molecular dynamics (CG MD) simulations to investigate the interactions of two RRCPPs, Tat(49–57)-NH2 (arginine-rich motif of Tat HIV-1 protein) and PTD4 (a less basic Ala-scan analog of the Tat peptide), with an artificial neuronal membr

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Tahoun, Amin, Gabriella Siszler, Kevin Spears, et al. "Comparative Analysis of EspF Variants in Inhibition of Escherichia coli Phagocytosis by Macrophages and Inhibition of E. coli Translocation through Human- and Bovine-Derived M Cells." Infection and Immunity 79, no. 11 (2011): 4716–29. http://dx.doi.org/10.1128/iai.00023-11.

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ABSTRACTThe EspF protein is secreted by the type III secretion system of enteropathogenic and enterohemorrhagicEscherichia coli(EPEC and EHEC, respectively). EspF sequences differ between EHEC O157:H7, EHEC O26:H11, and EPEC O127:H6 in terms of the number of SH3-binding polyproline-rich repeats and specific residues in these regions, as well as residues in the amino domain involved in cellular localization. EspFO127is important for the inhibition of phagocytosis by EPEC and also limits EPEC translocation through antigen-sampling cells (M cells). EspFO127has been shown to have effects on cellul

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Lewitzky, Marc, Maria Harkiolaki, Marie-Charlotte Domart, E. Yvonne Jones, and Stephan M. Feller. "Mona/Gads SH3C Binding to Hematopoietic Progenitor Kinase 1 (HPK1) Combines an Atypical SH3 Binding Motif, R/KXXK, with a Classical PXXP Motif Embedded in a Polyproline Type II (PPII) Helix." Journal of Biological Chemistry 279, no. 27 (2004): 28724–32. http://dx.doi.org/10.1074/jbc.m402745200.

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Keller, Rob C. A., and Wolf Frits A. de. "Physical-chemical characterization of thermoreversible gelatin helices." Industrial Proteins 4 (January 1, 1997): 14–15. https://doi.org/10.5281/zenodo.3229208.

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The testing of new gelatin batches for photographic purposes is a frequently recurring and tedious task that would benefit from efficient new methods for quality assessment. One of the quality parameters is the efficiency of gelation and the stability and strength of the gel and final photographic matrix. The objective of the present IOP-Industrial Proteins project was to contribute to the rationalization of the working mechanism of gelatin gelation. By studying the unique structural features of gelatin. The structure of the thermoreversible physical crosslinks (“junction zones”) a

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Lokes, K. P., D. S. Avetikov, S. O. Stavitsky, O. O. Rozkolupa, and N. S. Lutsenko. "THE FEATURES OF THE FACE SKIN CONSTRUCTION THAT INFLUENCE ON THE FORMATION OF CICATRICAL TISSUES DURING SUGICAL INTERVENTIONS." Ukrainian Dental Almanac, no. 4 (December 26, 2019): 19–23. http://dx.doi.org/10.31718/2409-0255.4.2019.03.

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Formation of pathological scars of maxillofacial localization after surgery is a significant and widespread problem of modern surgical stomatology and maxillofacial surgery. A significant percentage of patients who needs planned and urgent surgical interventions cause rapid development of reconstructive-restorative surgery of the maxillofacial region. The analysis of domestic and foreign literary sources was devoted to the peculiarities of the structure of the skin of the head and neck and the optimization of the skin incisions of this localization. Functional features of human ski

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Panjarian, Shoghag, Shugui Chen, John Engen, and Thomas Smithgall. "Enhanced SH3:Linker Interaction Suppresses Activating Mutations of the c-Abl Protein-Tyrosine Kinase." Blood 116, no. 21 (2010): 1208. http://dx.doi.org/10.1182/blood.v116.21.1208.1208.

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Abstract Abstract 1208 Bcr-Abl, the chimeric protein-tyrosine kinase expressed as a result of the Philadelphia chromosome translocation, plays a pivotal role in the initiation and maintenance of chronic myelogenous leukemia (CML). Imatinib (Gleevec) is an ATP-competitive Bcr-Abl inhibitor that selectively kills Bcr-Abl+ CML cells. Despite its clinical success, imatinib is less effective in the advanced stages of CML due to the emergence of drug resistance caused by point mutations in the Abl kinase domain. Second generation Bcr-Abl inhibitors such as dasatinib and nilotinib are active against

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Cayrou, Chloé, Astrid Walrant, Delphine Ravault, et al. "Incorporation of CF₃-pseudoprolines into polyproline type II foldamers confers promising biophysical features." Chemical Communications, 2024. http://dx.doi.org/10.1039/d4cc02895c.

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The development and the use of fluorinated polyproline-type II (PPII) foldamers are still underexplored. Herein, trifluoromethyl pseudoprolines have been incorporated into polyproline backbones without affecting their PPII helicity. The ability...

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