Bibliografías temáticas / HIV-1, HLA-C

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Literatura académica sobre el tema "HIV-1, HLA-C"

Autor: Grafiati
Publicado: 11 de marzo de 2023
Última modificación: 31 de julio de 2025

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Artículos de revistas sobre el tema "HIV-1, HLA-C"

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Muccini, Camilla, Monica Guffanti, Vincenzo Spagnuolo, et al. "Association between low levels of HIV-1 DNA and HLA class I molecules in chronic HIV-1 infection." PLOS ONE 17, no. 3 (2022): e0265348. http://dx.doi.org/10.1371/journal.pone.0265348.

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Background HLA-B27 and -B57 were found in people with low levels of HIV-1 DNA, suggesting that HLA class I molecules may influence the size of HIV-1 reservoir. Aim of the study was to explore the association between HLA class I molecules and HIV-1 DNA in people with chronic HIV-1 infection. Methods Post-hoc analysis of the APACHE trial, on adults with chronic HIV-1 infection, prolonged suppressive antiretroviral therapy and good immunological profile. HIV-1 DNA was quantified in peripheral blood mononuclear cells (PBMCs); HLA-A, -B and -C were tested on genomic DNA. Crude odds ratios (OR) with
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Zipeto, Donato, and Alberto Beretta. "C3 HIV-1 Env and HLA-C." JAIDS Journal of Acquired Immune Deficiency Syndromes 59 (April 2012): 77. http://dx.doi.org/10.1097/01.qai.0000413798.79651.e7.

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Apps, Richard, Gregory Q. Del Prete, Pramita Chatterjee, et al. "HIV-1 Vpu Mediates HLA-C Downregulation." Cell Host & Microbe 19, no. 5 (2016): 686–95. http://dx.doi.org/10.1016/j.chom.2016.04.005.

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Barker, Edward, and David T. Evans. "HLA-C Downmodulation by HIV-1 Vpu." Cell Host & Microbe 19, no. 5 (2016): 570–71. http://dx.doi.org/10.1016/j.chom.2016.04.023.

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Nii-Trebi, Nicholas I., Saori Matsuoka, Ai Kawana-Tachikawa, et al. "Super high-resolution single-molecule sequence-based typing of HLA class I alleles in HIV-1 infected individuals in Ghana." PLOS ONE 17, no. 6 (2022): e0269390. http://dx.doi.org/10.1371/journal.pone.0269390.

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Polymorphisms in human leukocyte antigen (HLA) class I loci are known to have a great impact on disease progression in HIV-1 infection. Prevailing HIV-1 subtypes and HLA genotype distribution are different all over the world, and the HIV-1 and host HLA interaction could be specific to individual areas. Data on the HIV-1 and HLA interaction have been accumulated in HIV-1 subtype B- and C-predominant populations but not fully obtained in West Africa where HIV-1 subtype CRF02_AG is predominant. In the present study, to obtain accurate HLA typing data for analysis of HLA association with disease p
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Kyobe, Samuel, Savannah Mwesigwa, Gyaviira Nkurunungi, et al. "Identification of a Clade-Specific HLA-C*03:02 CTL Epitope GY9 Derived from the HIV-1 p17 Matrix Protein." International Journal of Molecular Sciences 25, no. 17 (2024): 9683. http://dx.doi.org/10.3390/ijms25179683.

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Efforts towards an effective HIV-1 vaccine have remained mainly unsuccessful. There is increasing evidence for a potential role of HLA-C-restricted CD8+ T cell responses in HIV-1 control, including our recent report of HLA-C*03:02 among African children. However, there are no documented optimal HIV-1 CD8+ T cell epitopes restricted by HLA-C*03:02; additionally, the structural influence of HLA-C*03:02 on epitope binding is undetermined. Immunoinformatics approaches provide a fast and inexpensive method to discover HLA-restricted epitopes. Here, we employed immunopeptidomics to identify HLA-C*03
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Bachtel, Nathaniel D., Gisele Umviligihozo, Suzanne Pickering, et al. "HLA-C downregulation by HIV-1 adapts to host HLA genotype." PLOS Pathogens 14, no. 9 (2018): e1007257. http://dx.doi.org/10.1371/journal.ppat.1007257.

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Specht, Anke, Amalio Telenti, Raquel Martinez, et al. "Counteraction of HLA-C-Mediated Immune Control of HIV-1 by Nef." Journal of Virology 84, no. 14 (2010): 7300–7311. http://dx.doi.org/10.1128/jvi.00619-10.

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ABSTRACT A host genetic variant (−35C/T) correlates with increased human leukocyte antigen C (HLA-C) expression and improved control of HIV-1. HLA-C-mediated immunity may be particularly protective because HIV-1 is unable to remove HLA-C from the cell surface, whereas it can avoid HLA-A- and HLA-B-mediated immunity by Nef-mediated down-modulation. However, some individuals with the protective −35CC genotype exhibit high viral loads. Here, we investigated whether the ability of HIV-1 to replicate efficiently in the “protective” high-HLA-C-expression host environment correlates with specific fun
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Adnan, Sama, Arumugam Balamurugan, Alicja Trocha, et al. "Nef interference with HIV-1–specific CTL antiviral activity is epitope specific." Blood 108, no. 10 (2006): 3414–19. http://dx.doi.org/10.1182/blood-2006-06-030668.

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AbstractHIV-1 Nef and HIV-1–specific cytotoxic T lymphocytes (CTLs) have important and opposing roles in the immunopathogenesis of HIV-1 infection. Nef-mediated down-modulation of HLA class I on infected cells can confer resistance to CTL clearance, but the factors determining the efficiency of this process are unknown. This study examines the impact of Nef on the antiviral activity of several CTL clones recognizing epitopes from early and late HIV-1 proteins, restricted by HLA-A, -B, and -C molecules. CTL-targeting epitopes in early proteins remained susceptible to the effects of Nef, althoug
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Ende, Zachary, Martin J. Deymier, Daniel T. Claiborne, et al. "HLA Class I Downregulation by HIV-1 Variants from Subtype C Transmission Pairs." Journal of Virology 92, no. 7 (2018): e01633-17. http://dx.doi.org/10.1128/jvi.01633-17.

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ABSTRACTHIV-1 downregulates human leukocyte antigen A (HLA-A) and HLA-B from the surface of infected cells primarily to evade CD8 T cell recognition. HLA-C was thought to remain on the cell surface and bind inhibitory killer immunoglobulin-like receptors, preventing natural killer (NK) cell-mediated suppression. However, a recent study found HIV-1 primary viruses have the capacity to downregulate HLA-C. The goal of this study was to assess the heterogeneity of HLA-A, HLA-B, and HLA-C downregulation among full-length primary viruses from six chronically infected and six newly infected individua
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Tesis sobre el tema "HIV-1, HLA-C"

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Honeyborne, Isobella W. A. "Definition of HLA-B and HLA-C-restricted CD8+ T cell responses and their contribution to immune control of HIV-1 infection." Thesis, University of Oxford, 2008. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.504481.

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Corrah, Tumena Wandifa. "A study of the phenotype and function of HLA-C restricted CD8 T cells in HIV-1 infection." Thesis, University of Oxford, 2011. http://ora.ox.ac.uk/objects/uuid:456f2b57-55de-42ed-83ac-bcbd1d869bd0.

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A recent study showed that a polymorphism ~35kb upstream of the HLA-C gene (-35 SNP) correlates with host control of HIV-1 in Caucasians, with the minor allele (C) associating with significantly lower set point viral loads than the major allele (T). A link between viral load and HLA-C is suggested by linkage of the two SNP alleles with different HLA-C alleles and by the fact that HLA-C, in contrast to HLA-A and -B, is not down-regulated by HIV-1 Nef protein. In addition, the -35C variant has been shown to associate with higher HLA-C messenger RNA expression in EBV-transformed B cell lines. We
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Ribeiro, Susan Pereira. "Análise da imunogenicidade de uma vacina de DNA codificando epitopos CD4 promíscuos e conservados do HIV-1 em camundongos BALB/c e transgênicos para moléculas de HLA classe II." Universidade de São Paulo, 2010. http://www.teses.usp.br/teses/disponiveis/5/5146/tde-22092010-120821/.

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Abordagens atuais no desenho de vacinas contra o HIV-1 estão focadas em imunógenos que codificam proteínas inteiras do HIV-1 e visam induzir respostas citotóxicas específicas. É concebível que vacinas bem-sucedidas devem induzir respostas contra múltiplos epitopos do HIV-1, coincidindo com seqüências das cepas circulantes do vírus, conhecido por sua grande variabilidade genética. Sabe-se que células T CD4+ são necessárias para indução de respostas efetivas de linfócitos T CD8+ citotóxicos. Neste trabalho, nós avaliamos a imunogenicidade de uma vacina de DNA codificando 18 epitopos para linfóci
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Francesca, Parolini. "HIV-1 Env and HLA-C interaction is crucial in modulating viral infectivity." Doctoral thesis, 2018. http://hdl.handle.net/11562/979164.

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Introduction HLA-C plays a crucial role in the progression of HIV-1 infection. Host genetic HLA-C variants, appear to be associated with a different ability to control HIV-1 infection. A higher HLA-C expression is associated with a better activation of cytotoxic T lymphocytes (CTLs) and of Killer Immunoglobulin like receptors (KIR) on NK-cells, which lead to a better HIV-1 infection control. Vice-versa, a lower HLA-C expression leads to a rapid progression toward AIDS. In addition, different HLA-C alleles present different binding stabilities to β2microglobulin (β2m)/peptide. Noteworthy, some
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Stefani, Chiara. "Host factors restricting HIV-1 infectivity." Doctoral thesis, 2022. http://hdl.handle.net/11562/1073347.

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The field of host-retrovirus interactions is complex and wide since multiple cellular proteins can act as positive or negative factors for viral infections or pathogenesis. In this work, we investigated the role of some cellular proteins on HIV-1 infectivity. The first examined factor is HLA-C and its potential role in AIDS progression. The analysis of the HLA-C genotype of 96 HIV-1 positive patients unveils the statistically significant association between some HLA-C variants, less stably bound to β2microglobulin/peptide complex, and a more rapid AIDS progression (p-value = 0.0143). The
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Serena, Michela. "HIV-1 and host cell proteins interactions: role of Env and HLA-C in viral infectivity and molecular analysis of Nef and ACOT8 association." Doctoral thesis, 2015. http://hdl.handle.net/11562/914182.

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HIV-1, per compiere il suo ciclo infettivo, si serve dell’associazione con numerose proteine cellulari. In questo lavoro mi sono occupata di studiare l’interazione tra proteine di HIV-1 e proteine cellulari, in particolare tra Env e HLA-C e tra Nef e la tioesterasi umana (ACOT8). Studi precedenti hanno dimostrato come la presenza di HLA-C sui virioni di HIV-1 ne aumenti l’infettività; è stata inoltre riportata una correlazione tra i livelli di espressione di HLA-C e la replicazione virale. In questo studio abbiamo dimostrato che la presenza di HIV-1 aumenta la quantità di molecole HLA-C open c
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Capítulos de libros sobre el tema "HIV-1, HLA-C"

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Peter, Matuku-Kisaumbi. "The Role of TB Biomarkers in Diagnosis, Prognosis and Prevention of Tuberculosis." In Infectious Diseases. IntechOpen, 2024. http://dx.doi.org/10.5772/intechopen.115129.

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This chapter focuses on how biomarkers of tuberculosis can be utilized in the diagnosis, prognosis and treatment monitoring of TB. Tuberculosis biomarkers are measurable molecular indicators present and/or whose levels are altered in disease states. Found in blood, urine, bronchoalveolar lavage or sputum, biomarkers can originate from the bacteria (e.g. Ag85, lipoarabinomannan (LAM) and bacterial DNA) or from the host (e.g. cytokines/chemokines, metabolites, transcriptomics, mixed signatures and other proteins). Despite the lack of tuberculous specificity, Ag85 can facilitate early detection o
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Th y 1989) attempted to improve the usefulness of tele d ­ taitmtehemomsitdodf le thoefetah rl eec tw or ernetliae ti tohncsesnttruernyg , th beuntebdyag th a a in tcdooncnuemce ti notn patterns y work ha ing regions foorfstehaesognlaolbcelitm ha att , eipnreaddidcittiioonnb to y fille Adc in ru c w ia alspaap rt hyosfictahleepxipcltaunrdebteheantfro em rg aoitn ten atio ed . to be a m ls e o re lhyadshroew la itn io gnssh ta itp is stiw ca ilthEN EN SO SO -p rtehca ip t it w at eiroenhliignhklsy , t te hleecSoonuntehcetrinonOp sc aitltleartn io s. n A ju rsetvaisewaonfk fo nrow th leedogbesaeb rv oeudticdoennstiisftieendttfhreom se aespoin so sdaend to reegpiiosn od seo . f T th h e ey g p lo a b rt eicw ul haerr ly physical explanation precipitation was associated with ENSO in at least 75 e." In Droughts. Routledge, 2016. http://dx.doi.org/10.4324/9781315830896-39.

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Actas de conferencias sobre el tema "HIV-1, HLA-C"

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Izumi, Daichi, Junji Shimamura, Kyono Yasuda, et al. "Wide Range Buffering Capacity of HLP Solution for Long-term HIC Testing under Mildly Sour Conditions." In CONFERENCE 2022. AMPP, 2022. https://doi.org/10.5006/c2022-18078.

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ABSTRACT Hydrogen Induced Cracking (HIC) is a major issue of carbon steels for pipelines exposed to wet sour environments. For Fitness-for-Purpose (FFP) HIC evaluations which require a longer test duration than the conventional 96 h, Solution C was registered in NACE TM0284. However, because Solution C requires frequent pH adjustment using HCl and NaOH during HIC testing depending of the sour conditions, there is a strong need for a FFP testing solution with higher pH stability. The High-strength Line Pipe (HLP) Committee of The Iron and Steel Institute of Japan (ISIJ)(1) proposed a 5.0 wt% Na
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2

Mizuno, Daisuke, Nobuyuki Ishikawa, Takuya Hara, et al. "Long-term Performance of HLP Solution for Mildly Sour HIC Testing." In CORROSION 2017. NACE International, 2017. https://doi.org/10.5006/c2017-09129.

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Abstract Hydrogen Induced Cracking (HIC) is a major issue to develop carbon steels for pipelines exposed to wet sour environments. HIC susceptibility of steel plates and pipe products is commonly evaluated in accordance with NACE TM0284. In recent years, HIC evaluation in mildly sour conditions has been discussed to enhance usage of high strength steels such as X70 or higher grades. High Strength Line Pipe (HLP) Committee of The Iron and Steel Institute of Japan (ISIJ)(1) has investigated Fitness for Purpose (FFP) HIC evaluations and proposed 5% NaCl + 0.93 N (CH3COOH + CH3COONa) solution (HLP
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3

Santos, André Luiz Dos. "EXAMES IMUNOGENÉTICOS PARA AVALIAÇÃO DE COMPATIBILIDADE RECEPTOR-DOADOR EM TRANSPLANTES EM SUMA." In II Congresso Brasileiro de Biologia Molecular On-line. Revista Multidisciplinar em Saúde, 2021. http://dx.doi.org/10.51161/rems/2335.

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Introdução: Transplantes são processos onde a compatibilidade Receptor-Doador é fundamental para evitar-se a perda do paciente ou do órgão, que poderia ser melhor transplantado. Para isso, realizam-se múltiplos testes, principalmente clínicos e laboratoriais, avaliando ambos pacientes, buscando sucesso dos transplantes. Objetivo: Reconhecer a importância dos exames imunogenéticos para compatibilidade Receptor-Doador. Material e Métodos: Pesquisa descritiva em documentos científicos em português, no limite de dez anos, no Google Acadêmico e Scielo, destacando os termos: transplantes, imunogenét
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Preussner, Brian D., Joseph A. Nenni, and Vondell J. Balls. "An Overview of Risk Management Planning for Hot-Isostatic Pressure Treatment of High-Level Waste Calcine for the Idaho Cleanup Project." In ASME 2012 Pressure Vessels and Piping Conference. American Society of Mechanical Engineers, 2012. http://dx.doi.org/10.1115/pvp2012-78150.

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The Calcine Disposition Project (CDP) of the Idaho Cleanup Project (ICP) has the responsibility to retrieve, treat, and dispose of the calcine stored at the Idaho Nuclear Technology and Engineering Center (INTEC) located at the Idaho National Laboratory. Calcine is the granular product of thermally treating, or calcining liquid high-level waste (HLW) that was produced at INTEC during the reprocessing of spent nuclear fuel (SNF) to recover uranium. The CDP is currently designing the Hot Isostatic Pressure (HIP) treatment for the calcine to provide monolithic, glass-ceramic waste form suitable f
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Sayenko, Sergey Yu, G. A. Kholomeyev, B. A. Shilyaev, et al. "Preparing the Spent Nuclear Fuel for Long-Term Storage and Final Disposal by Encapsulating It Into Glass-Ceramic Waste Forms." In ASME 2001 8th International Conference on Radioactive Waste Management and Environmental Remediation. American Society of Mechanical Engineers, 2001. http://dx.doi.org/10.1115/icem2001-1212.

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Abstract This paper describes the research work carried out at the NSC KIPT to develop and apply a final waste form in the shape of a monolithic solid block for the containment of spent nuclear fuel. To prepare radioactive waste for long-term storage and final deep geological disposal, investigations into the development of methods of immobilizing HLW simulators in protective solid matrices are being conducted at the NSC KIPT. For RBMK spent nuclear fuel it is proposed and justified to encapsulate the spent fuel bundles into monolithic protective blocks, produced with the help of hot isostatic
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