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Artículos de revistas sobre el tema "Hypoglycemya"

Autor: Grafiati

Publicado: 4 de junio de 2021

Última modificación: 18 de febrero de 2022

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1

Abrahamsson, Niclas, Britt Edén Engström, Magnus Sundbom, and F. Anders Karlsson. "Hypoglycemia in everyday life after gastric bypass and duodenal switch." European Journal of Endocrinology 173, no. 1 (2015): 91–100. http://dx.doi.org/10.1530/eje-14-0821.

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DesignGastric bypass (GBP) and duodenal switch (DS) in morbid obesity are accompanied by marked metabolic improvements, particularly in glucose control. In recent years, episodes of severe late postprandial hypoglycemia have been increasingly described in GBP patients; data in DS patients are scarce. We recruited three groups of subjects; 15 GBP, 15 DS, and 15 non-operated overweight controls to examine to what extent hypoglycemia occurs in daily life.MethodsContinuous glucose monitoring (CGM) was used during 3 days of normal activity. The glycemic variability was measured by mean amplitude of

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2

Büyükkaya Besen, Dilek, Hamdiye Arda Sürücü, and Cansu Koşar. "Self-reported frequency, severity of, and awareness of hypoglycemia in type 2 diabetes patients in Turkey." PeerJ 4 (December 13, 2016): e2700. http://dx.doi.org/10.7717/peerj.2700.

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ObjectivesHypoglycemia is a common side effect of insulin therapy in type 1 and type 2 diabetes. Limited data exist on the frequency of hypoglycemic events in type 2 diabetic patients in Turkey. Our study investigated self-reported hypoglycemic events and awareness of hypoglycemia in Turkish patients with type 2 diabetes.MethodsPeople with type 2 diabetes older than 18 years of age were recruited from the two university hospital diabetes clinics. The frequency and severity of hypoglycemia and awareness of hypoglycemia during the preceding year were determinated using questionnaires by the face

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Yukina, Marina Yu, Nurana F. Nuralieva, Ekaterina A. Troshina, Nikolay S. Kuznetsov, and Nadezhda M. Platonova. "The hypoglycemic syndrome (insulinoma): pathogenesis, etiology, laboratory diagnosis (review, part 1)." Problems of Endocrinology 63, no. 4 (2017): 245–56. http://dx.doi.org/10.14341/probl2017634245-256.

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Hypoglycemic syndrome is a cluster of symptoms developing due to imbalance in the glucose homeostasis system leading to hypoglycemia and that is corrected by glucose administration. A rapid and significant drop of glucose blood level may lead to life-threatening condition, hypoglycemic coma. Chronic hypoglycemia leads to irreversible changes in the central nervous system, while forced frequent meals with high carbohydrate content in order to correct hypoglycemia significantly increases body weight, until morbid obesity develops. Hence, the hypoglycemic syndrome is a topical problem of contempo

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Parilo, Miguel A. "Gatifloxacin-Associated Hypoglycemia." Journal of Pharmacy Technology 18, no. 6 (2002): 319–20. http://dx.doi.org/10.1177/875512250201800605.

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Objective: To report a case of prolonged hypoglycemia associated with glyburide and gatifloxacin use. Case Summary: An 82-year-old white woman with diabetes mellitus type 2 and chronic renal insufficiency developed postoperative pneumonia. She had previously been on long-term glyburide therapy. Protracted hypoglycemia after institution of gatifloxacin developed despite discontinuation of oral hypoglycemic therapy. After 2 days of intravenous dextrose, sustained normoglycemia was achieved. Discussion: Hypoglycemic reactions with glyburide and fluoroquinolone antibiotics have been reported, but

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Haywood, Samuel C., Adam J. Bree, Erwin C. Puente, Dorit Daphna-Iken, and Simon J. Fisher. "Central but not systemic lipid infusion augments the counterregulatory response to hypoglycemia." American Journal of Physiology-Endocrinology and Metabolism 297, no. 1 (2009): E50—E56. http://dx.doi.org/10.1152/ajpendo.90673.2008.

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This study tests the hypothesis that lipids could act as an alternative fuel source in the brain during insulin-induced hypoglycemia. Male Sprague-Dawley rats were subjected to hyperinsulinemic (5 mU·kg−1·min−1) hypoglycemic (∼50 mg/dl) clamps. In protocol 1, intralipid (IL), a fat emulsion, was infused intravenously to prevent the fall in free fatty acid levels that occurs in response to hyperinsulinemic hypoglycemia. Intravenous lipid infusion did not alter the counterregulatory responses to hypoglycemia. To test whether IL could have central effects in mediating the counterregulatory respon

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Zahed, Karim, Farzan Sasangohar, Ranjana Mehta, Madhav Erraguntla, Mark Lawley, and Khalid Qaraqe. "Investigating the Efficacy of Using Hand Tremors for Early Detection of Hypoglycemic Events: A Scoping Literature Review." Proceedings of the Human Factors and Ergonomics Society Annual Meeting 62, no. 1 (2018): 1211–15. http://dx.doi.org/10.1177/1541931218621278.

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Diabetes is a prevalent condition affecting millions of patients globally. Some diabetic patients suffer from a deadly condition called Hypoglycemia (sudden drop in blood glucose levels). Continuous Glucose Monitors (CGMs) have been the most pervasive tool used to track blood glucose levels but these tools are invasive and costly. While early detection of hypoglycemia has been studied, current approaches do not leverage tremors; which are a primary symptom of hypoglycemia. A scoping review was conducted to understand the relationship between tremors and hypoglycemia, and to document any effort

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7

Hekimsoy, Zeliha, Sevinç Biberoǧlu, Abdurrahman Çömlekçi, Oktay Tarhan, Cem Mermut, and Kadir Biberoǧlu. "Trimethoprim/sulfamethoxazole-induced hypoglycemia in a malnourished patient with severe infection." European Journal of Endocrinology 136, no. 3 (1997): 304–6. http://dx.doi.org/10.1530/eje.0.1360304.

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Abstract Hypoglycemia resulting from the combination of sulfonylurea and sulfonamides is a recognized drug interaction. Hypoglycemia induced by sulfonamides alone may be encountered less frequently. Because of their structural similarities to sulfonylureas. sulfonamides are liable to facilitate hypoglycemia by increasing insulin release in susceptible individuals. Sulfonamides can potentiate the hypoglycemic effect of sulfonylurea agents when given in combination. We describe a malnourished patient with severe infection who developed hypoglycemia during high-dose trimethoprim/sulfamethoxazole

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8

Kim, Mina, Zhao-Xue Yu, Bertil B. Fredholm, and Scott A. Rivkees. "Susceptibility of the developing brain to acute hypoglycemia involving A1 adenosine receptor activation." American Journal of Physiology-Endocrinology and Metabolism 289, no. 4 (2005): E562—E569. http://dx.doi.org/10.1152/ajpendo.00112.2005.

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It has been suggested that the developing brain is less vulnerable to the adverse effects of hypoglycemia than the mature brain; however, this issue remains controversial. We also do not know the magnitude or duration of hypoglycemia needed to trigger hypoglycemic brain injury during development. To address this issue a series of in vivo and in vitro studies were performed. First, we established an acute model of insulin-induced hypoglycemia in mice by administering 3 U/kg of neutral-protamine Hagadorn insulin subcutaneously. When we examined degenerating neurons in hippocampus and striatum by

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9

Hong, Susana, Lubaina Presswala, Yael T. Harris, et al. "Hypoglycemia in Patients with Type 2 Diabetes Mellitus and Chronic Kidney Disease: A Prospective Observational Study." Kidney360 1, no. 9 (2020): 897–903. http://dx.doi.org/10.34067/kid.0001272020.

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BackgroundGlycemic management in patients with type 2 diabetes mellitus (T2DM) and CKD can become complicated. One factor that may affect treatment is hypoglycemia. Hypoglycemia risk may be increased by several biologic processes in CKD. The objective of this study was to determine the frequency, severity, and risk factors for hypoglycemia in patients with T2DM and CKD.MethodsThe design was a prospective observational study. A continuous glucose monitor (CGM) was worn by 80 patients for up to 14 days; glucose was measured every 15 minutes. Patients with T2DM and eGFR <45 ml/min were enrolle

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Sharma, Suresh K., and Ravi Kant. "Awareness of Symptoms and Early Management of Hypoglycemia among Patients with Diabetes Mellitus." Journal of Diabetes and Endocrinology Association of Nepal 1, no. 1 (2018): 12–17. http://dx.doi.org/10.3126/jdean.v1i1.21190.

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Background: Hypoglycemia mostly occurs in diabetic patients on medications. Lack of awareness on hypoglycemic symptoms among patients may delay its identification and treatment. The symptoms of hypoglycemic symptoms among patients may delay its identification and treatment. Neglecting the symptoms of hypoglycemia and delaying treatment could cause poorer outcomes or morbidity. The present study was aimed to assess the awareness of symptoms of hypoglycemia and knowledge in early management of hypoglycemia among patients with diabetes.Methods: A Cross sectional study was done among 500 diabetes

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Yukina, M. Yu, N. F. Nuralieva, E. A. Troshina, and V. A. Ioutsi. "Clinical case of factitious hypoglycemia." Meditsinskiy sovet = Medical Council, no. 7 (May 29, 2020): 130–36. http://dx.doi.org/10.21518/2079-701x-2020-7-130-136.

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Hypoglycemic syndrome (HGS) is a significant decrease glucose in blood, manifested by neurological symptoms, and stopped by the introduction of glucose. Among the many causes of HGS the special place is taken by the factitious hypoglycemia, as one of the variants of Munchausen syndrome. Hypoglycemia in such cases is achieved by the intentional introduction of hypoglycemic drugs. The most commonly used medications are sulfonylurea derivatives, which are affordable, inexpensive and legal. The close collaboration of clinicians with the laboratory service plays a key role in the diagnosis of facti

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12

Jackson, Lesley, Fiona L. R. Williams, Ann Burchell, Michael W. H. Coughtrie, and Robert Hume. "Plasma Catecholamines and the Counterregulatory Responses to Hypoglycemia in Infants: A Critical Role for Epinephrine and Cortisol." Journal of Clinical Endocrinology & Metabolism 89, no. 12 (2004): 6251–56. http://dx.doi.org/10.1210/jc.2004-0550.

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Abstract The purpose of this study was to define plasma catecholamine responses as part of the counterregulatory hormonal reaction to hypoglycemia in infants after a regular 3- to 4-h feed was omitted. Hormone levels were assessed once, at the end of the fast or at hypoglycemia. The 121 infants were subdivided into three groups for analysis: normoglycemia (n = 94, 78%); transient hypoglycemia (n = 11, 9%); or severe and persistent hypoglycemia (n = 16, 13%). The severe and persistent hypoglycemic group had significantly higher levels of cortisol and epinephrine than the normoglycemic group. No

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13

Johnson, Jeffrey A., Joanne E. Kappel, and M. Nabi Sharif. "Hypoglycemia Secondary to Trimethoprim/Sulfamethoxazole Administration in a Renal Transplant Patient." Annals of Pharmacotherapy 27, no. 3 (1993): 304–6. http://dx.doi.org/10.1177/106002809302700309.

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OBJECTIVE: To report a case of trimethoprim/sulfamethoxazole (TMP/SMX)-induced hypoglycemia in an immunosuppressed renal transplant patient. DATA SOURCES: English-language journal articles and reference texts identified via a MEDLINE search and a bibliographic review of pertinent data sources. DATA SYNTHESIS: Hypoglycemia resulting from the combination of sulfonylureas and sulfonamides is a recognized drug interaction. Hypoglycemia induced by sulfonamides alone may be encountered less frequently. Previously reported cases of TMP/SMX-induced hypoglycemia postulated that the sulfonamide mimics h

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14

Abs, Roger, Louis Verbist, Marleen Moeremans, Pierre Blockx, Ivo De Leeuw, and Jozef Bekaert. "Hypoglycemia owing to inappropriate glucagon secretion treated with a continuous subcutaneous glucagon infusion system." Acta Endocrinologica 122, no. 3 (1990): 319–22. http://dx.doi.org/10.1530/acta.0.1220319.

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Abstract A selective glucagon deficiency was documented in a 36-year-old female patient suffering from severe hypoglycemic attacks. The extremely low fasting plasma glucagon levels could not be stimulated by hypoglycemia. The increase in plasma glucagon during stimulation with arginine did not prevent hypoglycemia provoked by the simultaneous insulin secretion. Treatment consisting of a continuous sc glucagon infusion system resulted in correction of both postabsorptive and postprandial hypoglycemia. Further lowering of the glucose level during an arginine test could be the hallmark of this hy

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15

de Galan, Bastiaan E., Saskia J. Rietjens, Cees J. Tack, et al. "Antecedent Adrenaline Attenuates the Responsiveness to But Not the Release of Counterregulatory Hormones during Subsequent Hypoglycemia." Journal of Clinical Endocrinology & Metabolism 88, no. 11 (2003): 5462–67. http://dx.doi.org/10.1210/jc.2003-030407.

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Abstract Hypoglycemia unawareness is thought to be the consequence of recurrent hypoglycemia, yet the underlying mechanism is still incompletely understood. The aim of the present study was to determine the role of antecedent elevated adrenaline in the pathogenesis of hypoglycemia unawareness. Sixteen healthy volunteers (eight of either sex) participated in two experiments, performed in random order and at least 3 wk apart. During the morning, three consecutive doses of 0.04, 0.06, and 0.08 μg·kg−1·min−1 of adrenaline or matching placebo (normal saline) were infused for the total duration of 1

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Sandoval, Darleen A., Deanna L. Aftab Guy, M. Antoinette Richardson, Andrew C. Ertl, and Stephen N. Davis. "Acute, same-day effects of antecedent exercise on counterregulatory responses to subsequent hypoglycemia in type 1 diabetes mellitus." American Journal of Physiology-Endocrinology and Metabolism 290, no. 6 (2006): E1331—E1338. http://dx.doi.org/10.1152/ajpendo.00283.2005.

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Exercise-induced hypoglycemia can occur within hours after exercise in type 1 diabetes mellitus (T1DM) patients. This study tested the hypothesis that an acute exercise bout causes (within hours) blunted autonomic and metabolic responses to subsequent hypoglycemia in patients with T1DM. Twelve T1DM patients (3 W/9 M) were studied during a single-step, 2-h hyperinsulinemic (572 ± 4 pmol/l) hypoglycemic (2.8 ± 0.1 mmol/l) clamp 2 h after either a hyperinsulinemic euglycemic (AM EUG) or hypoglycemic clamp (AM HYPO) or after sitting in a chair with basal insulin infusion (AM CON) or 90 min of mode

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Singh, Kuldeep, and Anjali M. Kher. "Clinico-biochemical profile of hypoglycemia in neonates admitted in NICU." International Journal of Contemporary Pediatrics 6, no. 1 (2018): 20. http://dx.doi.org/10.18203/2349-3291.ijcp20184694.

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Background: In high risk neonates’ incidence of hypoglycemia is up to 30%. There is limited evidence-based consensus regarding screening and management of neonates at risk of hypoglycemia. This study was undertaken to know the incidence, clinical profile, sequential blood glucose level upto 72 hours and short-term outcome of neonatal hypoglycemia.Methods: Blood sugar was screened at admission, after feed or D10 bolus, 6, 12, 24, 48 and 72 hours of age. Detailed maternal history and neonatal history, clinical manifestation, management and short-term outcome of hypoglycemic neonates were noted.

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Shahid, Madhia, Gabriel Q. Shaibi, Hayley Baines, Pamela Garcia-Filion, Zoe Gonzalez-Garcia, and Micah Olson. "Risk of hypoglycemia in youth with type 2 diabetes on insulin." Journal of Pediatric Endocrinology and Metabolism 31, no. 6 (2018): 625–30. http://dx.doi.org/10.1515/jpem-2018-0014.

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Abstract Background: The objective of this study was to ascertain the risk of hypoglycemia among youth with type 2 diabetes (T2D) on insulin therapy. Methods: Twenty-two youth with T2D on insulin therapy (M=12, F=10, age=14.4±4.0 years) were enrolled from a single pediatric endocrine practice. They were followed-up for 3 months with weekly phone calls and monthly in-person visits to review blood glucose logs and document any signs or symptoms of hypoglycemia (defined as finger stick glucose of ≤70 mg/dL). Episodes of hypoglycemia were categorized into five categories: severe, documented sympto

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Yukina, Marina, Nurana Nuralieva, Ekaterina Troshina, Natalya Malysheva, Zamira Zuraeva, and Alina Bratchikova. "Clinical Case of Surreptitious Hypoglycemia Due to Deliberate Insulin Analog Administration." Clinical Medicine Insights: Case Reports 14 (January 2021): 117954762110092. http://dx.doi.org/10.1177/11795476211009234.

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Hypoglycemic syndrome is a life-threatening condition that can lead to hypoglycemic coma and death. Surreptitious hypoglycemic syndrome is the deliberate use of insulin preparations or oral hypoglycemic drugs aimed to reduce blood glucose level. If human insulin is injected, high level of immunoreactive insulin (IRI) and low level of C-peptide at the moment of hypoglycemia are always detected. However, the fact of deliberate administration of insulin analogs is difficult to prove. In these cases if insulin kit test with low cross-reactivity with insulin analogs is used, the low levels of IRI a

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Mohamed, Ashraf, Christine Bolen, Jennifer Morgan, et al. "Reducing Morning Hypoglycemia Among Children Undergoing Treatment for Acute Lymphoblastic Leukemia." JCO Oncology Practice 17, no. 6 (2021): e901-e907. http://dx.doi.org/10.1200/op.20.00652.

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PURPOSE: Hypoglycemia has been observed in children receiving acute lymphoblastic leukemia (ALL) therapy, and it can negatively affect patient outcomes. We documented a 4%-6% prevalence of hypoglycemia among patients in the two clinics in this study. We aim to reduce morning hypoglycemia in children on chemotherapy for ALL at two community pediatric oncology clinics (A and B) by 50% in 9 months. METHODS: We used the Institute for Healthcare Improvement (IHI) Model for Improvement as the framework. Prolonged hours of fasting for procedural sedation, gaps in the caregivers' knowledge of hypoglyc

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Pratipanawatr, Thongchai, Bancha Satirapoj, Boonsong Ongphiphadhanakul, Sompongse Suwanwalaikorn, and Wannee Nitiyanant. "Impact of Hypoglycemia on Health-Related Quality of Life among Type 2 Diabetes: A Cross-Sectional Study in Thailand." Journal of Diabetes Research 2019 (October 23, 2019): 1–8. http://dx.doi.org/10.1155/2019/5903820.

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Type 2 diabetes mellitus (T2DM) is one of the most common chronic diseases. Patients are generally advised lifestyle changes with antihyperglycemic agents prescribed. The major drawback of prescribing antihyperglycemic agents is the risk of hypoglycemia which subsequently impacts on health-related quality of life (HRQoL). This study is aimed at examining association between previous history of hypoglycemia and HRQoL. The study was a multicenter cross-sectional study, conducted from February 2013 to March 2015 at 5 tertiary care hospitals in Thailand (Srinagarind, Phramongkutklao, Ramathibodi,

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de Courten-Myers, Gabrielle M., Guohua Xi, Jong-Hee Hwang, et al. "Hypoglycemic Brain Injury: Potentiation from Respiratory Depression and Injury Aggravation from Hyperglycemic Treatment Overshoots." Journal of Cerebral Blood Flow & Metabolism 20, no. 1 (2000): 82–92. http://dx.doi.org/10.1097/00004647-200001000-00012.

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Hypoglycemia can cause brain dysfunction, brain injury, and death. The present study seeks to broaden current information regarding mechanisms of hypoglycemic brain injury by investigating a novel etiology. The cat's high resistance to brain injury from hypoglycemia suggested that additional influences such as respiratory depression might play a facilitating role. Three groups of cats were exposed to fasting and insulin-induced hypoglycemia (HG; n = 6), euglycemic respiratory depression (RD; n = 5), and combined hypoglycemic respiratory depression (HG/RD; n = 10). The HG animals were maintaine

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Heller, Simon R., Mark Peyrot, Shannon K. Oates, and April D. Taylor. "Hypoglycemia in patient with type 2 diabetes treated with insulin: it can happen." BMJ Open Diabetes Research & Care 8, no. 1 (2020): e001194. http://dx.doi.org/10.1136/bmjdrc-2020-001194.

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There are many misconceptions about the prevalence and effects of hypoglycemia in people with type 2 diabetes (T2D), including hypoglycemia does not occur or does not have adverse consequences in T2D. This narrative review aims to help dispel these myths. Around 25% of people with T2D taking insulin for >5 years were found to have severe hypoglycemic events, which is comparable to the severe hypoglycemia rate in adults with type 1 diabetes (T1D) diagnosed within 5 years. The total number of hypoglycemic events among insulin-treated T2D, including severe hypoglycemia, is as high or higher th

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Sanders, Nicole M., Charles W. Wilkinson, Gerald J. Taborsky, et al. "The selective serotonin reuptake inhibitor sertraline enhances counterregulatory responses to hypoglycemia." American Journal of Physiology-Endocrinology and Metabolism 294, no. 5 (2008): E853—E860. http://dx.doi.org/10.1152/ajpendo.00772.2007.

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Selective serotonin reuptake inhibitors (SSRIs) are widely prescribed for patients with comorbid diabetes and depression. Clinical case studies in diabetic patients, however, suggest that SSRI therapy may exacerbate hypoglycemia. We hypothesized that SSRIs might increase the risk of hypoglycemia by impairing hormonal counterregulatory responses (CRR). We evaluated the effect of the SSRI sertraline on hormonal CRR to single or recurrent hypoglycemia in nondiabetic rats. Since there are time-dependent effects of SSRIs on serotonin neurotransmission that correspond with therapeutic action, we eva

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Hollinger, B. R., and R. M. Bryan. "Beta-receptor-mediated increase in cerebral blood flow during hypoglycemia." American Journal of Physiology-Heart and Circulatory Physiology 253, no. 4 (1987): H949—H955. http://dx.doi.org/10.1152/ajpheart.1987.253.4.h949.

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We tested the hypothesis that beta-adrenergic receptor stimulation is involved with the increase in regional cerebral blood flow (rCBF) during hypoglycemia. Rats were surgically prepared with the use of halothane-nitrous oxide anesthesia. A plaster restraining cast was placed around the hindquarters, and anesthesia was discontinued. Hypoglycemia was produced by an intravenous injection of insulin (15 U/kg); normoglycemic control rats were given saline. Propranolol (1.5 mg/kg) was administered to some control and some hypoglycemic rats to block the beta-adrenergic receptors. Regional CBF was me

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Rozance, Paul J., Sean W. Limesand, Gary O. Zerbe та William W. Hay. "Chronic fetal hypoglycemia inhibits the later steps of stimulus-secretion coupling in pancreatic β-cells". American Journal of Physiology-Endocrinology and Metabolism 292, № 5 (2007): E1256—E1264. http://dx.doi.org/10.1152/ajpendo.00265.2006.

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We measured the impact of chronic late gestation hypoglycemia on pancreatic islet structure and function to determine the cause of decreased insulin secretion in this sheep model of fetal nutrient deprivation. Late gestation hypoglycemia did not decrease pancreas weight, insulin content, β-cell area, β-cell mass, or islet size. The pancreatic islet isolation procedure selected a group of islets that were larger and had an increased proportion of β-cells compared with islets measured in pancreatic sections, but there were no morphologic differences between islets isolated from control and hypog

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Syed, Shumail, and Alain Joseph Taylon. "Losartan Induced Hypoglycemia in the Absence of Diabetes Mellitus - a Concealed Diagnosis." Journal of the Endocrine Society 5, Supplement_1 (2021): A391. http://dx.doi.org/10.1210/jendso/bvab048.796.

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Abstract Background: Losartan has been shown to attenuate symptomatic and hormonal responses to hypoglycemia in prior studies. This results predominantly from blocking AT-II receptors blunting the hypoglycemia-induced rise in plasma epinephrine predisposing them to hypoglycemia unawareness. To our knowledge, however there are no case reports describing losartan induced hypoglycemia in a nondiabetic patient. This abstract is the first description of a patient without diabetes mellitus experiencing severe hypoglycemia induced by the ARB, Losartan. Clinical Case: A 51- year old nondiabetic female

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Karaglani, Makrina, Georgia Ragia, Maria Panagopoulou, et al. "Search for Pharmacoepigenetic Correlations in Type 2 Diabetes Under Sulfonylurea Treatment." Experimental and Clinical Endocrinology & Diabetes 127, no. 04 (2018): 226–33. http://dx.doi.org/10.1055/s-0043-121265.

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AbstractSulfonylureas are insulin secretagogues which act in pancreatic β cells by blocking the KATP channels encoded by KCNJ11 and ABCC8 genes. In the present study, a pharmacoepigenetic approach was applied for the first time, investigating the correlation of KCNJ11 and ABCC8 gene promoter methylation with sulfonylureas-induced mild hypoglycemic events as well as the KCNJ11 E23K genotype. Sodium bisulfite-treated genomic DNA of 171 sulfonylureas treated T2DM patients previously genotyped for KCNJ11 E23K, including 88 that had experienced drug-associated hypoglycemia and 83 that had never exp

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Hanley, James F., Darin D. Willardsen, and Robert Biberdorf. "Profound Hypoglycemia in a Mail-Order Pharmacy Customer as a Result of a Dispensing Error." Hospital Pharmacy 37, no. 7 (2002): 734–36. http://dx.doi.org/10.1177/001857870203700714.

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Accidental hypoglycemia is most commonly associated with the inadvertent ingestion of oral hypoglycemic drugs, and profound hypoglycemia can result in significant morbidity and mortality. Dispensing errors involving sulfonylureas are usually cited as the cause, and these errors have historically been related to sound-alike compounds or proximity errors. We present the case of a patient who received sulfonylureas meant for a different patient through the mail and simply complied with the instructions on the medication bottle, with the result of severe hypoglycemia. This case demonstrates the ne

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Fruehwald-Schultes, Bernd, Werner Kern, Eva Deininger, et al. "Protective Effect of Insulin against Hypoglycemia-Associated Counterregulatory Failure." Journal of Clinical Endocrinology & Metabolism 84, no. 5 (1999): 1551–57. http://dx.doi.org/10.1210/jcem.84.5.5675.

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Antecedent hypoglycemic episodes reduce the counterregulatory neuroendocrine response to hypoglycemia. The role of insulin in the mechanism responsible for the antecedent hypoglycemia causing subsequent counterregulatory failure has not been elucidated. We performed antecedent hypoglycemic clamps (56 mg/dL) lasting 2 h with differing degrees of hyperinsulinemia, which were followed by 6-h stepwise hypoglycemic clamps (76–66–56–46 mg/dL) on the next day. Experiments were carried out in 30 young, healthy men. Fifteen of these subjects were tested on 2 occasions. On 1 occasion the antecedent hypo

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Dessouky, Arigue A., Zienab A. Gouda, Mona A. A. Arafa, Yaser H. A. Elewa, Amany M. Abo-Ouf, and Eman M. Askar. "Hypoxia-Preconditioned Human Umbilical Cord Blood-Derived Mesenchymal Stem Cells Mitigate Hypoglycemic Testicular Injury Induced by Insulin in Rats." Cells Tissues Organs 209, no. 2–3 (2020): 83–100. http://dx.doi.org/10.1159/000510363.

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Hypoglycemia is a neglected metabolic disorder. Thus, we evaluated the protective effect of hypoxia-preconditioned human umbilical cord blood-derived mesenchymal stem cells (hUCB-MSCs) on hypoglycemic testicular injury. We examined 56 testes from 28 animals: 7 rats with insulin-induced hypoglycemia (HG group), 7 hypoglycemic rats which received an intratesticular injection of hUCB-MSCs (HG-MSC group), and 14 untreated control rats. Testosterone level, testicular catalase (CAT) activity, and malondialdehyde (MDA) level were analyzed. Immunostaining for specific testicular germ and somatic cell

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DeRosa, Michael A., and Philip E. Cryer. "Hypoglycemia and the sympathoadrenal system: neurogenic symptoms are largely the result of sympathetic neural, rather than adrenomedullary, activation." American Journal of Physiology-Endocrinology and Metabolism 287, no. 1 (2004): E32—E41. http://dx.doi.org/10.1152/ajpendo.00539.2003.

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The relative contributions of the sympathetic nervous system and the adrenal medullae, the two components of the sympathoadrenal system, to the manifestations of hypoglycemia are largely unknown. We tested the hypothesis that the neurogenic symptoms of hypoglycemia are largely the result of sympathetic neural activation. To do so, we quantitated neurogenic symptoms, as well as norepinephrine (NE) kinetics and selected hemodynamic changes, during hyperinsulinemic euglycemic and stepped hypoglycemic clamps in 15 healthy control subjects (Controls) and four bilaterally adrenalectomized patients (

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Clus, Simona, Gabriela Creteanu, and Amorin Popa. "Silent Hypoglycemia in Patients with Diabetes." Internal Medicine 15, no. 6 (2018): 21–28. http://dx.doi.org/10.2478/inmed-2018-0042.

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AbstractIntroduction. Iatrogenic hypoglycemia increases cardiovascular morbidity sometimes even with fatalities, and also increases cognitive disorders in most people with type 1 diabetes (T1D) and type 2 diabetes (T2D). Hypoglycemia is characterized by unawareness if the sympathoadrenal response is attenuated during the night, in autonomic neuropathy or in elderly patients. Therefore, hypoglycemia is a limiting factor in the glycemic management of diabetes.Methods. We aimed to analyze the hypoglycemic events and the time spent with low glucose level (glucose <3.9 mmol/l) in patients with d

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Davis, S. N., and D. Tate. "Effects of Morning Hypoglycemia on Neuroendocrine and Metabolic Responses to Subsequent Afternoon Hypoglycemia in Normal Man1." Journal of Clinical Endocrinology & Metabolism 86, no. 5 (2001): 2043–50. http://dx.doi.org/10.1210/jcem.86.5.7495.

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There is general agreement that prior hypoglycemia blunts subsequent hypoglycemic counterregulatory responses. However, there is considerable debate concerning the timing and number of prior hypoglycemic episodes required to cause this blunting effect. The aim of this study was to determine whether one episode of hypoglycemia could modify neuroendocrine, metabolic, and symptom responses to hypoglycemia induced 2 h later. A total of 24 (12 male and 12 female) young, healthy, overnight-fasted subjects participated in a series of glucose clamp studies. A total of 16 individuals underwent 2 random

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Tkacs, Nancy C., Yanhua Pan, Ramesh Raghupathi, Ambrose A. Dunn-Meynell, and Barry E. Levin. "Cortical Fluoro-Jade Staining and Blunted Adrenomedullary Response to Hypoglycemia after Noncoma Hypoglycemia in Rats." Journal of Cerebral Blood Flow & Metabolism 25, no. 12 (2005): 1645–55. http://dx.doi.org/10.1038/sj.jcbfm.9600152.

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Intensive insulin therapy in patients with type 1 diabetes mellitus reduces long-term complications; however, intensive therapy is also associated with a three-fold increase in hypoglycemic episodes. The present study in conscious rats characterizes the physiologic and neuropathologic consequences of a single episode of moderate hypoglycemia. In this model, intravenous insulin is used to reduce plasma glucose to 30 to 35 mg/dL for 75mins. This single hypoglycemic insult acutely induces hypoglycemia-associated autonomic failure (HAAF), with epinephrine responses to hypoglycemia reduced more tha

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Clus, Simona, Gabriela Crețeanu, and Amorin Popa. "Nocturnal Hypoglycemia in Type 2 Diabetes." Romanian Journal of Diabetes Nutrition and Metabolic Diseases 25, no. 1 (2018): 99–103. http://dx.doi.org/10.2478/rjdnmd-2018-0011.

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Abstract Background and aims: It is known that the majority of critical unacknowledged hypoglycemia has an increased incidence in patients with type 1 diabetes (T1DM) with a long evolution. The aim of this research is to evaluate the variability of glucose level and hypoglycemic events in patients with type 2 diabetes (T2DM) having pharmacological interventions with hypoglycemic risk. These events are sometimes asymptomatic also in T2DM: frequently in elderly, patients with autonomic neuropathy, or having a long evolution of disease. Material and method: This analysis includes 72 patients with

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Donovan, Casey M., and Alan G. Watts. "Peripheral and Central Glucose Sensing In Hypoglycemic Detection." Physiology 29, no. 5 (2014): 314–24. http://dx.doi.org/10.1152/physiol.00069.2013.

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Hypoglycemia poses a serious threat to the integrity of the brain, owing to its reliance on blood glucose as a fuel. Protecting against hypoglycemia is an extended network of glucose sensors located within the brain and in the periphery that serve to mediate responses restoring euglycemia, i.e., counterregulatory responses. This review examines the various glucose sensory loci involved in hypoglycemic detection, with a particular emphasis on peripheral glucose sensory loci and their contribution to hypoglycemic counterregulation.

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Moin, Abu Saleh Md, Hassan Kahal, Ahmed Al-Qaissi, et al. "Amyloid-related protein changes associated with dementia differ according to severity of hypoglycemia." BMJ Open Diabetes Research & Care 9, no. 1 (2021): e002211. http://dx.doi.org/10.1136/bmjdrc-2021-002211.

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IntroductionHypoglycemia in type 2 diabetes (T2D) may increase risk for Alzheimer’s disease (AD), but no data on changes in AD-related proteins with differing degrees of hypoglycemia exist. We hypothesized that milder prolonged hypoglycemia would cause greater AD-related protein changes versus severe transient hypoglycemia.Research design and methodsTwo prospective case-control induced hypoglycemia studies were compared: study 1, hypoglycemic clamp to 2.8 mmol/L (50 mg/dL) for 1 hour in 17 subjects (T2D (n=10), controls (n=7)); study 2, hypoglycemic clamp to 2.0 mmol/L (36 mg/dL) undertaken tr

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Russell, Raymond R., Deborah Chyun, Steven Song, et al. "Cardiac responses to insulin-induced hypoglycemia in nondiabetic and intensively treated type 1 diabetic patients." American Journal of Physiology-Endocrinology and Metabolism 281, no. 5 (2001): E1029—E1036. http://dx.doi.org/10.1152/ajpendo.2001.281.5.e1029.

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Insulin-induced hypoglycemia occurs commonly in intensively treated patients with type 1 diabetes, but the cardiovascular consequences of hypoglycemia in these patients are not known. We studied left ventricular systolic [left ventricular ejection fraction (LVEF)] and diastolic [peak filling rate (PFR)] function by equilibrium radionuclide angiography during insulin infusion (12 pmol · kg−1 · min−1) under either hypoglycemic (∼2.8 mmol/l) or euglycemic (∼5 mmol/l) conditions in intensively treated patients with type 1 diabetes and healthy nondiabetic subjects ( n = 9 for each). During hypoglyc

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K.C., Indu. "Causes of Hypoglycemia in Hospitalized Diabetic Patients Referred to Endocrine Department of a Tertiary Level Hospital of India." Medical Journal of Shree Birendra Hospital 15, no. 1 (2016): 26–31. http://dx.doi.org/10.3126/mjsbh.v15i1.15018.

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Introduction: Diabetes mellitus (DM) results from relative deficiency or reduced effectiveness of endogenous insulin leading to both micro-vascular and macro-vascular complications. Treatment goal is intensive therapy as early as possible in patients with both type-1 and type-2 diabetes to bring the HbA1c to less than 7%. Occurrence of hypoglycemia in a diabetic patient is a common side effect of treatment. This study was aimed to find the causes of Hypoglycemia in diabetes patients. Methods: It was hospital based cross-sectional observational study on admitted diabetes patients with other co-

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Hilleman, Daniel E., Syed M. Mohiuddin, Ismail S. Ahmed, and Joann M. Dahl. "Cibenzoline-Induced Hypoglycemia." Drug Intelligence & Clinical Pharmacy 21, no. 1 (1987): 38–40. http://dx.doi.org/10.1177/10600280870211p104.

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Antiarrhythmic-induced hypoglycemia is an ill-defined phenomenon. Sporadic cases have been reported with disopyramide, a class IA antiarrhythmic agent. We report a case of cibenzoline-induced hypoglycemia in an elderly male with a history of ischemic heart disease, congestive heart failure, ventricular arrhythmias, and chronic obstructive pulmonary disease. Cibenzoline is a class I antiarrhythmic agent currently undergoing clinical investigation in the U.S. The initial hypoglycemic episode occurred after two years of successful treatment with cibenzoline. Blood glucose during the first hypogly

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Shum, Kathy, Karen Inouye, Owen Chan, et al. "Effects of antecedent hypoglycemia, hyperinsulinemia, and excess corticosterone on hypoglycemic counterregulation." American Journal of Physiology-Endocrinology and Metabolism 281, no. 3 (2001): E455—E465. http://dx.doi.org/10.1152/ajpendo.2001.281.3.e455.

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This study aimed to differentiate the effects of repeated antecedent hypoglycemia, antecedent marked hyperinsulinemia, and antecedent increases in corticosterone on counterregulation to subsequent hypoglycemia in normal rats. Specifically, we examined whether exposure to hyperinsulinemia or elevated corticosterone per se could impair subsequent counterregulation. Four groups of male Sprague-Dawley rats were used: 1) normal controls (N) had 4 days of sham antecedent treatment; 2) an antecedent hypoglycemia group (AH) had 7 episodes of hyperinsulinemic hypoglycemia over 4 days; 3) an antecedent

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Haas, Andrea, Rebecca Easly, Andrew Koefoed, et al. "Hypoglycemia Impairs Baroreflex Sensitivity: Implications for Autonomic Control of Cardiovascular Function in Diabetes." Journal of the Endocrine Society 5, Supplement_1 (2021): A447—A448. http://dx.doi.org/10.1210/jendso/bvab048.915.

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Abstract Background: Iatrogenic hypoglycemia is an unintended, though common, occurrence in individuals with diabetes. There is a clear association between hypoglycemia exposure and an increase in mortality in individuals with type 2 diabetes (T2DM). It is well-established that recurrent hypoglycemic episodes impair the counterregulatory hormone responses; however, it is yet to be determined if in T2DM there are more global effects of hypoglycemia on autonomic control of cardiovascular function (baroreflex sensitivity, BRS), as has been shown in healthy individuals. This is a clinically releva

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Mohamed, Ashraf Mahmoud, Christine Marie Bolen, Jennifer Morgan, Patricia Rice, Meredith Speas, and Carolyn Russo. "A quality improvement initiative for reducing morning hypoglycemia in children undergoing treatment for acute lymphoblastic leukemia." Journal of Clinical Oncology 37, no. 27_suppl (2019): 240. http://dx.doi.org/10.1200/jco.2019.37.27_suppl.240.

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240 Background: Hypoglycemia has been observed in children receiving Acute Lymphoblastic Leukemia (ALL) therapy. It affects patients’ outcome. The current quality initiative was piloted at two of the St Jude affiliate clinics. Each month about 10% of children with ALL develop hypoglycemia in those two clinics. Methods: Data was collected for the eight months prior to intervention. Root Cause Analysis (RCA) using fish bone diagram, and Pareto chart to find out the most likely causes of hypoglycemia. Prolonged hours of fasting for procedures, giving 6MP at night on empty stomach, seem to further

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Okazaki, Moemi, Masafumi Okazaki, Miho Nakamura, Tadashi Asagiri, and Seisho Takeuchi. "Consecutive hypoglycemia attacks induced by co-trimoxazole followed by pentamidine in a patient with acquired immunodeficiency syndrome." International Journal of STD & AIDS 30, no. 1 (2018): 86–89. http://dx.doi.org/10.1177/0956462418795580.

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Both co-trimoxazole and pentamidine are used for the treatment of pneumocystis pneumonia (PCP) and are known to cause hypoglycemia as an adverse drug reaction. Here, we describe a rare case of a late-diagnosed female patient with acquired immunodeficiency syndrome (AIDS) who developed the first hypoglycemic attack as an adverse effect of co-trimoxazole, followed by a second hypoglycemic attack as an adverse effect of pentamidine. Physicians caring for patients with AIDS and PCP should be aware of possible hypoglycemia in patients with many risk factors.

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Limesand, Sean W., Paul J. Rozance, Laura D. Brown, and William W. Hay. "Effects of chronic hypoglycemia and euglycemic correction on lysine metabolism in fetal sheep." American Journal of Physiology-Endocrinology and Metabolism 296, no. 4 (2009): E879—E887. http://dx.doi.org/10.1152/ajpendo.90832.2008.

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In this study, we determined rates of lysine metabolism in fetal sheep during chronic hypoglycemia and following euglycemic recovery and compared results with normal, age-matched euglycemic control fetuses to explain the adaptive response of protein metabolism to low glucose concentrations. Restriction of the maternal glucose supply to the fetus lowered the net rates of fetal (umbilical) glucose (42%) and lactate (36%) uptake, causing compensatory alterations in fetal lysine metabolism. The plasma lysine concentration was 1.9-fold greater in hypoglycemic compared with control fetuses, but the

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Guzmán, Guillermo, Veline Martínez, Julián David Yara, et al. "Glycemic Control and Hypoglycemia in Patients Treated with Insulin Pump Therapy: An Observational Study." Journal of Diabetes Research 2020 (August 5, 2020): 1–8. http://dx.doi.org/10.1155/2020/1581726.

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Introduction. Diabetes mellitus (DM) is a highly prevalent disease worldwide. It has been associated with an important morbimortality due to its complications and sometimes as a result of adverse events related to treatment. Insulin pump therapy (IPT) is one of the options used to control this disease and reduces one of the most frequent complication associated with treatment: hypoglycemia, which has also a great impact on life quality and clinical status of patients. Materials and Methods. A descriptive and retrospective study was performed including patients treated and followed by the depar

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White, Bryan P., and Robin Southwood. "Persistent Hypoglycemia of Unknown Etiology in a Patient Without Diabetes." Journal of Pharmacy Practice 26, no. 2 (2013): 138–43. http://dx.doi.org/10.1177/0897190012465984.

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Purpose: This case report reviews the presentation, evaluation, and treatment of persistent hypoglycemia in a patient without a history of diabetes. The use of laboratory tests to differentiate between drug-induced and disease-induced hypoglycemia is reviewed. Summary: A 51-year-old female with multiple medical conditions including bipolar disorder and no history of diabetes was admitted for evaluation and treatment of hypoglycemia. Pharmacotherapy included intravenous dextrose infusions and bolus doses. A battery of tests was ordered to evaluate intrinsic and extrinsic causes. Endocrine Socie

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Fidan, Cihan, Funda Salgur, Ozdemir Efe Kul, et al. "Incidence and Costs of Hypoglycemia among Type II Diabetes Mellitus Patients in Turkey." Journal of Biomedical Research & Environmental Sciences 2, no. 8 (2021): 705–12. http://dx.doi.org/10.37871/jbres1300.

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We aimed to determine the lifetime and one-year incidence of hypoglycemia in adults who had been treated following a diagnosis of Type II Diabetes Mellitus (T2DM), the factors that affected this incidence, and its effect on the use of health care resources. The descriptive cross-sectional cost study included adult T2DM patients who had an outpatient examination. Using a face-to-face interview method, patients were required to complete a questionnaire containing questions about sociodemographic characteristics, T2DM diagnosis and treatment features, and hypoglycemia events. Episode treatment co

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Matveyenko, Aleksey V., MaryAnn Bohland, Maziyar Saberi, and Casey M. Donovan. "Portal vein hypoglycemia is essential for full induction of hypoglycemia-associated autonomic failure with slow-onset hypoglycemia." American Journal of Physiology-Endocrinology and Metabolism 293, no. 3 (2007): E857—E864. http://dx.doi.org/10.1152/ajpendo.00283.2007.

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Antecedent hypoglycemia leads to impaired counterregulation and hypoglycemic unawareness. To ascertain whether antecedent portal vein hypoglycemia impairs portal vein glucose sensing, thereby inducing counterregulatory failure, we compared the effects of antecedent hypoglycemia, with and without normalization of portal vein glycemia, upon the counterregulatory response to subsequent hypoglycemia. Male Wistar rats were chronically cannulated in the carotid artery (sampling), jugular vein (glucose and insulin infusion), and mesenteric vein (glucose infusion). On day 1, the following three distin

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