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1

Pereira, Sanchez Laura. "b-jet identification and searches for supersymmetry, dark matter and Higgs boson pair production with the ATLAS experiment". Licentiate thesis, Stockholms universitet, Fysikum, 2020. http://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-186308.

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2

Mochizuki, Kazuya. "Search for the Higgs boson in the WH->lvbb channel with the ATLAS detector : development of high performance b-jet identification algorithm". Thesis, Aix-Marseille, 2015. http://www.theses.fr/2015AIXM4065.

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En juillet 2012, les collaborations ATLAS et CMS ont annoncé la découverte d’une nouvelle particule à une masse d'environ 125 GeV, compatible avec le boson de Higgs prédit par le Modèle Standard (MS). Bien qu’à ce jour toutes les mesures montrent une pleine cohérence avec les prédictions du MS, les canaux de désintégration H->bb n'ont pas encore été vus aussi clairement que les canaux de autre désintégration. Cette thèse présente une recherche du boson de Higgs dans le canal WH->lvbb, en utilisant les données de collisions proton-proton à sqrt(s)=8 TeV prises avec le détecteur ATLAS en 2012, correspondant à une luminosité intégrée de 20,3 fb-1. Ce document détaille l’une des contributions aites par l'auteur à cette recherche: la région d’analyse supplémentaire avec des événements de muons déclenchés par l'impulsion transverse manquante. Un excès par rapport à l'hypothèse de fond seulement a été trouvé avec une signification statistique de 1,8(1,5) sigma observée(attendue). La limite supérieure observée(attendue) sur le produit section efficace par rapport d’embranchement pour WH->lvbb à un niveau de confiance de 95% est de 2,35(1,37) fois la prédiction du MS pour mH=125 GeV. Cette recherche repose fortement sur l’identification des jets issus du quark b. Afin d'améliorer la recherche H->bb utilisant l'identification des jets b dans ATLAS, le développement d'algorithmes de haute performance a été conduit et est présenté également dans cette thèse. Un nouvel algorithme, appelé MV2, est introduit: il améliore la performance d'identification des jets b de manière significative et est maintenant l'algorithme référencee pour les analyses du Run 2 avec ATLAS
In July 2012, the ATLAS and CMS collaborations announced the discovery of a new particle at a mass of about 125 GeV, compatible with the Higgs boson predicted by the Standard Model (SM) ofparticle physics. Although all measurements as of Summer 2015 show a full consistency with the SM predictions, the H->bb decay channel has not been seen yet as clearly as the other decay channels. This thesis presents a search for the Higgs boson in the WH->lvbb channel, using proton-proton collision data at sqrt(s) = 8 TeV taken with the ATLAS detector in the year 2012, corresponding to an integrated luminosity of 20.3 fb-1. This document details in particular one of the contributions made by the author in this search: the additional analysis region with muon events triggered by missing transverse momentum. An excess over the background-only hypothesis has been found with a significance of 1.8 sigma while 1.5 sigma was expected. The observed (expected) upper limit on the cross-section times branching ratio for WH->lvbb at 95% confidence level is found to be 2.35 (1.37) times the SM prediction at mH = 125 GeV. This search highly relies on the identification of jets originating in b-quark fragmentation, so-called b-tagging. In order to improve the H->bb search and other physics analyses using b-tagging in ATLAS, the development of high performance b-tagging algorithms has been performed and is presented also in this thesis. A new b-tagging algorithm, called MV2, is introduced: it improves the b-tagging performance significantly and is now the baseline b-tagging algorithm in ATLAS for the Run-2 analyses
3

Coubez, Xavier. "Search for the standard Higgs boson produced in association with a pair of top quark in the multi-leptons channel in the CMS experiment". Thesis, Strasbourg, 2017. http://www.theses.fr/2017STRAE049/document.

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La découverte en 2012 de la dernière particule élémentaire prédite par le Modèle Standard, le boson de Higgs, a ouvert une nouvelle ère en physique des particules. L’un des objectifs est désormais de sonder les couplages du boson de Higgs aux autres particules afin de confirmer la validité du modèle. Le travail de cette thèse a porté dans un premier temps sur l’identification de jets issus de quark b dès le système de déclenchement. L’objectif est de permettre de sélectionner un millier d’événements parmi les quarante millions produits chaque seconde au LHC en identifiant des objets présents dans l’état final de processus de physique intéressants tels que la production associée d’un boson de Higgs se désintégrant en paire de quark b avec un boson Z se désintégrant en neutrinos non détectés. Dans un second temps, l’étude du couplage du boson de Higgs au quark top, particule la plus massive au sein du Modèle Standard a été réalisée. Après l’étude d’un bruit de fond important de la production associée d’un boson de Higgs et d’une paire de quarks top, une nouvelle méthode a été utilisée pour améliorer la discrimination entre le signal et les principaux bruits de fond. Cette analyse a conduit à la première évidence expérimentale du couplage entre le boson de Higgs et le quark top
The discovery in 2012 of the last elementary particle predicted by the Standard Model, the Higgs boson, has opened a new era in particle physics. One of the objectives now is to probe the coupling of the Higgs boson to other particles in order to confirm the validity of the model. The work of this thesis focused initially on the identification of jets coming from b quark at trigger level. The goal is to allow for the selection of one thousand events among the forty million produced every second at the LHC, by identifiying objects present in the final states of interesting physics processes such as the associated production of a Higgs boson decaying in a pair of b quark with a Z boson decaying into undetected neutrinos. The work then moved to the study of the coupling of the Higgs boson to the quark top, most massive particle in the Standard Model. After a study of one of the important background of the associated production of the Higgs boson and a top quark pair, a new method called matrix element method has been used to improve the discrimination between signal and background. This analysis has led to the first experimental evidence of coupling between the Higgs boson and the top quark
4

Calvet, Thomas. "Search for the production of a Higgs boson in association with top quarks and decaying into a b-quark pair and b-jet identification with the ATLAS experiment at LHC". Thesis, Aix-Marseille, 2017. http://www.theses.fr/2017AIXM0312/document.

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En Juillet 2012, les expériences ATLAS et CMS annoncent la découverte d'une nouvelle particule de masse 125 GeV, compatible avec le boson de Higgs prédit par le Modèle Standard. Pour établir la nature de ce boson de Higgs et la comparer au Modèle Standard, il est nécessaire de mesurer le complage du boson de Higgs au fermions. En particulier le quark top possède le plus fort couplage de Yukawa avec le boson de Higgs. Ce couplage est accessible par le processus de production d'un boson de Higgs en association avec une paire de quarks tops (ttH). Cette thèse présente la recherche d'évènement ttH où le boson de Higgs se désintègre en deux quark b dans les données du Run 2 recueillies en 2015 et 2016 par le détecteur ATLAS. La composition du bruit de fond ainsi que la mesure du signal ttH dans les données sont obtenues à partir d'un ajustemement statistique des prédictions aux données. Le bruit de fond tt+jets étant la plus grande source d'incertitudes sur le signal, une attention particulière est portée à sa description.La détection des jets issus de quarks b, appelé b-tagging, est primordiale pour l'analyse ttH(H->bb) dont l'état final contient quatre quarks b. Afin d'améliorer la compréhension des performances des algorithmes de b-tagging pour le Run 2, la définition des jets de saveur b dans les simulations Monte Carlo est revisitée. Les algorithmes standards du b-tagging ne permettant pas la différenciation des jets contenant un ou deux quarks b, une methode spécifique à été développée et est présentée dans cette thèse
In July 2012, the ATLAS and CMS experiments announced the discovery of a new particle, with a mass about 125 GeV, compatible with the Standard Model Higgs boson. In order to assess if the observed particle is the one predicted by the Standard Model, the couplings if this Higgs boson to fermions have to be measured. In particular, the top quark has the strongest Yukawa coupling to the Higgs boson. The associated production of a Higgs boson with a pair of top quarks (ttH) gives a direct access to this coupling. The ttH process is accessible for the first time in the Run 2 of the LHC thanks to an upgrade of the detector and the increase of the center of mass energy to 13 TeV. This thesis presents the search for ttH events with the Higgs boson decaying to a pair of b-quarks using data collected by the ATLAS detector in 2015 and 2016. The description of the background and the extraction of the ttH signal in data are obtained by a statistical matching on predictions to data. In particular the tt+jets background is the main limitation to signal sensitivity and is scrutinized.The identification of jets originating from b-quarks, called b-tagging, is a vital input to the search of ttH(H->bb) events because of the four b-quarks in the final state. For Run 2 the definition of b-flavoured-jets in Monte Carlo simulations is revisited to improve the understanding of b-tagging algorithms and their performance. Standard b-tagging algorithms do not separate jets originating from a single b-quark from those originating from two b-quarks. Thus a specific method has been developed and is reviewed in this thesis
5

Ticse, Torres Royer Edson. "Search for the Higgs boson in the ttH(H -> bb) channel and the identification of jets containing two B hadrons with the ATLAS experiment". Thesis, Aix-Marseille, 2016. http://www.theses.fr/2016AIXM4052/document.

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En juillet 2012, le CERN a annoncé la découverte du boson de Higgs qui est la dernière particule manquante du Modèle Standard (MS). Le boson de Higgs a été observé dans différents canaux. La mesure précise de ses propriétés est maintenant très importante pour rechercher des déviations par rapport au SM. Cette thèse présente une recherche du boson de Higgs produit en association avec une paire de quarks top et se désintégrant en une paire de b quark, le canal ttH(H → bb) , en utilisant les données de collisions proton-proton à √s = 13 TeV, collectées avec le détecteur ATLAS en 2015 et 2016. Ce document détaille en particulier la reconstruction du systéme ttH et la séparation du signal du bruit de fond principal tt + jets. Des études récentes montrent qu'il existe une fraction importante du bruit de fond ttbb avec des jets contenant deux hadrons b. Un nouvel algorithme a été développé pour séparer ces jets des jets contenant un seul b-hadron. La description de cet outil est présenté dans cette thèse
In July 2012, CERN announced the discovery of the Higgs boson, the last missing piece of the Standard Model (SM). The Higgs boson was observed in different channels. Precise measurement of its properties is now very important to investigate for possible deviations from the SM. This thesis presents a search for the Higgs boson produced in association with top quarks and decaying to a b quark pair, the ttH(H→bb) channel, using proton-proton collisions at √s = 13 TeV, collected with the ATLAS detector in 2015 and 2016. This document details in particular the full reconstruction of the ttH(H→bb) system and the discrimination between signal and the main background, tt+jets. The ttbb is a subset of the tt+jets backgrounds recent studies show that there is a large fraction of ttbb events with jets containing two b-hadrons. A new algorithm has been developed to discriminate such jets from single b-hadrons jets. The description of this tool is presented in this thesis
6

Li, Changqiao. "b-tagging calibration and observation of Higgs boson decays to a pair of bottom quarks with the atlas detector". Thesis, Sorbonne université, 2018. http://www.theses.fr/2018SORUS620.

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Cette thèse décrit dans un premier temps la mesure d’efficacité d’identification des jets b grâce à la méthode tag-and-probe utilisant les données enregistrées par le détecteur ATLAS en 2015 et 2016. La méthode de mesure de l’efficacité, la sélection des objets, des événements et des jets sondes, l’évaluation des incertitudes systématiques et statistiques sont présentées. Les efficacités d’identification des jets b ont été mesurées en fonction du moment transverse des jets, de leurs pseudo-rapidités et du nombre moyen de collisions (pile-up). Les efficacités mesurées dans les données ont été comparées aux prédictions des simulations, et ainsi des facteurs d’échelles ont été extraits. Les valeurs obtenues sont proche de un, avec des incertitudes allant de 2% à 12%.Dans un deuxième temps, cette thèse décrit la recherche de la désintégration du boson de Higgs décrit par le modèle standard en une paire quark/anti-quark b dans le canal de production associée avec un boson vecteur. Deux résultats obtenus sont décrits: le premier avec les données collectées par ATLAS avec de collisions protons protons à 13 TeV lors du Run2 du LHC jusqu’en 2016 (36.1 fb-1), puis un second ajoutant les données obtenues dans les mêmes conditions en 2017 (44 fb-1).Le premier résultat est présenté avec une description de la technique de reconstruction des objets, de la sélection des événements et de leur classification, des techniques de discrimination entre le signal et le bruit de fond, de la modélisation des principaux bruits de fond, des propriétés du signal ainsi que de l’interprétation des résultats. Pour le deuxième étude, basée sur les 80 fb-1 données collectées, seules les différences d’avec la première étude sont mises en lumière.Les deux résultats apportent une forte évidence statistique de la production avec des significances respectives de 3.5 et 4.9 déviation standard. L’intensité du signal, définie comme le rapport entre la mesure et la prédiction théorique de la section efficace multipliée par le rapport d’embranchement , obtenue avec les données est , ce qui indique un bon accord entre les données et le modèle standard. La combinaison du résultat basé sur les données à 80 fb-1 obtenues à une énergie dans le centre de masse de 13 TeV avec les données obtenues avec une énergie inférieure (7 et 8 TeV) en 2011 et 2012, ainsi qu’avec les recherches de la désintégration dans les autres canaux de production (fusion de bosons vecteurs, production associée avec une paire de quark top) a permis l’observation de la désintégration avec une significance statistique de 5.4 déviation standard, et une mesure de l’intensité de signal . Une combinaison du résultat basée sur les données à 80 fb-1 obtenues à une énergie dans le centre de masse de 13 TeV avec les recherches dans le même canal de production et avec les mêmes données brutes dans les états finaux en deux photons et ZZ∗ → 4l, a permis l’observation de la production associée du boson de Higgs avec un boson vecteur avec une significance statistique de 5.3 deviation standard, et une mesure de l’intensité de signal , ce qui confirme le bon accord avec la théorie du modèle standard
This thesis firstly describes a measurement of the b-jet tagging efficiency with a tag-and-probe method using data recorded by the ATLAS detector in 2015 and 2016. The efficiency measurement method, the object selection, the event and probe jet selection, the evaluation of the statistical and systematic uncertainties, and the final results are discussed. The b-tagging efficiencies have been measured as a function of the jet transverse momentum, pseudorapidity and of the average number of pile-up collisions. The efficiencies measured in data have been compared to those predicted from simulation, and simulation-to-data efficiency scale factors have been determined. The efficiency scale factors are close to unity, with total uncertainty ranging between 2% and 12%. The second part of this thesis focuses on the search for the decays of the Standard Model (SM) Higgs boson to bottom quarks in the associated production mode with vector bosons. Two measurements have been performed and are described here: the first one is based on of 13 TeV pp collisions recorded by ATLAS during the LHC Run-2 until 2016; the second one includes the additional of 13 TeV pp collisions recorded in 2017. For the study based on of data, the object reconstruction, event selection and classification, the techniques to discriminate the signal from the background, the main background and their modelling, the signal properties and the interpretation of results are discussed. For the study based on data, the main difference from the previous study are highlighted. Both results provide a strong evidence of the process, with statistical significances of 3.5 and 4.9 standard deviations, respectively. The signal strength, defined as the ratio between the measured cross section times branching ratio and the SM prediction, is measured with the 2015–2017 dataset to be , indicating good agreement with the SM. The combination of the results based on of 13 TeV collisions with the results of the same analysis performed on data collected at lower (7 and 8 TeV) centre-of-mass energies in 2011 and 2012, and witht those of the searches of decays in other Higgs boson production modes (vector-boson fusion, associated production with a top-quark pair) have led to the observation of the decay with a significance of 5.4 standard deviations, and to a measurement of the signal strength . A combination of the results of the results based on of 13 TeV collisions with the results of searches for the same production mode on the same amount of data in the diphoton and ZZ∗ → 4l Higgs boson final states has led to the observation of VH production with a significance of 5.3 standard deviations, and to a measurement of the signal strength , in good agreement with the SM
7

Sasidharan, Nair Unnikrishnan. "Jet noise source localization and identification". The Ohio State University, 2017. http://rave.ohiolink.edu/etdc/view?acc_num=osu1482412964456451.

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8

Belias, Anastasios. "Electron/jet discrimination and b-jet tagging at the second level trigger of ATLAS". Thesis, Royal Holloway, University of London, 2000. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.326090.

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9

Camboni, Alessandro. "Inclusive b-jet production cross section measurement at LHCb". Doctoral thesis, Universitat de Barcelona, 2013. http://hdl.handle.net/10803/129459.

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The LHCb detector features an outstanding capability to identify displaced secondary vertices with respect to the interaction point. The extraordinary performance of the whole LHCb tracking system makes possible accurate measurements for particles’ trajectories and momenta. Many lifetime and kinematic based properties of the decay of the long-lived B hadrons are at the basis of the identification of b-jets, thus the LHCb detector could prove to be suitable to perform QCD studies based on heavy-quark jets. The aim of the analysis is to calculate the inclusive bb quark pair production cross section inside the range η ∈ (2.5, 4.0). For this purpose, a cone jet algorithm has been developed to reconstruct and identify jets from the B decay. It relies on how well the measured B hadron approximates the properties of the b quark in order to infer the cross section of b quarks production. Monte Carlo productions of fully simulated events in which a b quark pair has been produced have been used to study the correlation between the emerging quarks and the resulting B hadron pairs. Due to the large mass of the b quark, for which it turns to be less affected by non-perturbative QCD effects than lighter quarks, most of the properties of the b are retained by the corresponding B hadron. Thus may be safe to infere the b production cross section from inclusive B final states. The method used here is also expected to be less affected by non-perturbative effects than other measurements based on exclusive channel decays. The jet reconstruction tool developed to identify the jets originating from the b quark hadronisation is a cone-type seeded algorithm: the basic idea is to take an inclusive secondary vertex originating from the long-lived B hadron as seed for jet reconstruction. The position of the seed with respect to the primary verted establishes the direction of a cone of given aperture. The jet is then built collecting charged and neutral particles that are found to be inside the cone. The radius of the cone is expressed in terms of the dimensionless parameter Rin the (φ, η) plane (azimuthal angle and pseudorapidity). Seed track candidates are properly preselected with requirements on transverse momentum, χ2 of the resulting track fit and impact paramenter significance IPS (= IP/σIP) with respect to the PV. Goodness of vertex is ensured with cuts on the resulting vertex fit χ2 and on the distance of closest approach between the two tracks (DOCA). The reconstructed seed are found to describe well the B hadron direction: the φ and θ resolution evaluated for signal seeds turns out to be (15.8 ± 0.2) mrad and (1.82 ± 0.18) mrad respectively. Jets are then built and their properties studied, such as their b-tagging efficiency and spatial overlapping. Monte Carlo simulations have also been used to study the LHCb trigger. A handful of trigger lines have been selected meeting the following requirements: good efficiency in selecting signal events, the inclusive feature of the analysis must be preserved, difficult evaluation of systematic effects has to be avoided. A jet energy correction has been studied and applied in order to account for energy loss due to undetected particles or wrong energy measurement and tracking. This allows to compare Monte Carlo and real data and define a fiducial cut on the transverse momentum of the jets. Events are finally selected requiring them:  to have only one reconstructed primary vertex (to avoid ambiguous assignation of tracks to the proper primary vertex);  to have at least one reconstructed secondary vertex;  to be accepted by at least one line of each trigger stage. The measurement has been performed using 17.7 pb−1 of data, about ½ of the total luminosity collected in 2010 at 7Tev. Background from c-jets and light quarks and gluons has been studied using LHCb Monte Carlo simulations. The bbˉ production cross has been found to be σbbˉ = 80.6 ± 1.2 (stat) ± 11.4 (syst) μb, compatible within 1 sigma with NLO predictions.
El colisionador de hadrones superconductor LHC es el accelerador de partículas de energía más alta del mundo, actualmente produce colisiones de protones a un energía en el centro de masa de sqrt{s}=8 TeV. El detector LHCb es dedicado al estudio de física de los sabores pesados en LHC. Su objetivo principal es buscar evidencias indirectas de nueva física en la violación CP y en los decaimientos raros de los hadrones que contienen quarks b y c. La excelente capacidad de LHCb para identificar vértices desplazados de decaimientos de hadrones B se basa en un localizador de trazas de silicio (VELO) puesto alrededor del punto de interacción. Las prestaciones del VELO garantizan una resolución espacial altamente superiór a los demás experimentos situados en en LHC. Una identificación eficiente de b-jets (chorros de partículas inicializados a partir de la fragmentación de un quark b) con respecto a jets de otros sabores ha de aprovechar necesariamente las propiedades de producción y desintegración de los hadrones B. Dado que el objetivo del análisis es medir la sección eficaz de producción de quarks b en LHCb usando estados finales inclusivos con sabor b, también es indispensable la investigación de las correlaciones entre la producción del quark b y el correspondiente hadrón B, así como las correlaciones entre la pareja bb y la pareja resultante de hadrones B. Predicciones Monte Carlo (MC) permiten estimar como las propiedades del quark se modifican al pasar al nivel de hadrón por procesos como la fragmentación. Gracias a su particular función de fragmentación, el mesón B lleva gran parte de la energia del quark originado en la colisión primaria. Por lo tanto, el método aquí utilizado se espera que sea menos afectado por efectos no perturbativos que otras medidas basadas en canales de decaimiento exclusivos. El fondo del análisis consiste en una componente física, principalmente de jets de hadrones que derivan de la hadronización de quarks c y ligeros, y un fondo combinatorio, definido como los sucesos en que una pareja bb ha sido efectivamente producida y el algoritmo reconstruye jets no físicamente asociados a los quarks de señal. La parte combinatoria requiere una definición de jet para poderse estudiar. La herramienta de tagging desarrollada para identificar los jets provenientes de la hadronización del quark b es un algoritmo de jet de tipo cono: la idea básica es tomar un vértice inclusivo secundario procedentes de un hadrón B como seed (semilla) para la reconstrucción del jet. La posición del seed respecto al vértice primario (PV) establece la dirección de un cono de apertura dada. El jet se construye recogiendo las partículas cargadas y neutras que se encuentran en el interior del cono. Una ventaja de este método es el alta estadística que permite explorar correlaciones angulares entre las parejas bb y una región cinemática más grande en comparación con reconstrucciones exclusivas. Las trazas cargadas candidatas se seleccionan con requisitos sobre el impulso transverso, calidad de la reconstrucción de las trazas y significancia del parametro de impacto respecto al PV. La línea de vuelo de los hadrones B se reproduce con buena precisión por la posición del seed respecto al PV. Los jets se construyen sumando al quadrimomento del seed otras partículas cargadas y neutras que se encuentran dentro de un cono con el eje que coincide con la trayectoria del seed. Los requisitos para que los sucesos de señal MC sean acceptados preven la respuesta positiva de las lineas de trigger y de stripping seleccionadas para el análisis. Otros requisitos son la reconstrucción de exactamente un PV, y almenos un seed. Se han definido cortes fiduciales en la pseudorapidez eta y en el Pt de los jets, para garantizar la completa reconstrucción de los jets, así evitando inconstistencias infrarrojas en la aplicación de un algoritmo de tipo cono al fondo de quark y gluones. Una corrección de la energía es necesaria para tener en cuenta la pérdida de energía debido a partículas no detectadas o por medidas no correctas de la energía o del tracking. La idea aplicada ha sido calibrar la energía de los jets utilizando jets a nivel de generador Monte Carlo. El objetivo del análisis es calcular la sección eficaz de producción de parejas bb dentro del volumen fiducial (FV). Los datos analizados son los recogidos en el 2010 con colisiones a $\sqrt s = 7$ TeV. La eficiencia de selección tanto para la señal como para el fondo se ha determinado con las simulaciones MC. Las eficiencias de selección del fondo se han utilizado para estimar el número de sucesos de fondo esperados en una luminosidad igual a la de los datos analizados. Se ha utilizado este método debido a la falta de suficiente estadística MC que permitiera el ajuste de distribuciones de los datos y la extracción de las correspondientes fracciones de especies seleccionadas. La sección eficaz en el interval fiducial ha sido medida en 80.6 microbarns.
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McDufford, Michael D. "Identification of noise sources in a heated jet flow". Connect to resource, 2006. http://hdl.handle.net/1811/6440.

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Thesis (Honors)--Ohio State University, 2006.
Title from first page of PDF file. Document formatted into pages: contains vi, 38 p.; also includes graphics. Includes bibliographical references (p. 37-38). Available online via Ohio State University's Knowledge Bank.
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Carlson, Paul Chester-John. "Developing a b-jet tagging algorithm for ALICE lessons from CDF /". Click here to view, 2009. http://digitalcommons.calpoly.edu/physsp/4/.

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Thesis (B.S.)--California Polytechnic State University, 2009.
Project advisor: Jennifer Klay. Title from PDF title page; viewed on Feb. 4, 2010. Includes bibliographical references. Also available on microfiche.
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Bieniek, S. P. "Two b or not two b-jets : measurements of inclusive and dijet b-jet differential cross-sections with the ATLAS detector". Thesis, University College London (University of London), 2013. http://discovery.ucl.ac.uk/1410936/.

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This thesis discusses the measurement of the inclusive b-jet cross-section using the 2010 ATLAS dataset and the measurement of di-b-jet cross-sections using the 2011 dataset. The inclusive b-jet analysis measured the pT spectrum of b-jets in the range 20
13

Slack, David Nicholas. "Identification of I#kappa#B#alpha# interacting factors". Thesis, St George's, University of London, 1999. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.313393.

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14

Birkin, Ria H. "The identification of novel protein kinase B substrates". Thesis, University of Bristol, 2006. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.435741.

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15

Fleckner, Johanna Elisabeth [Verfasser]. "Tracking, b-tagging and measurement of the b-jet production cross section with the ATLAS detector / Johanna Elisabeth Fleckner". Mainz : Universitätsbibliothek Mainz, 2011. http://d-nb.info/1026803241/34.

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16

Zevi, Della Porta Giovanni. "Measurement of the Cross-Section for W Boson Production in Association with b-Jets in Proton-Proton Collisions at \(\sqrt s = 7\) TeV at the LHC using the ATLAS detector". Thesis, Harvard University, 2013. http://dissertations.umi.com/gsas.harvard:11031.

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This dissertation presents a measurement of the W+b-jets \((pp → W + b(\bar{b}) + X)\) production cross-section in proton–proton collisions at a center-of-mass energy of 7 TeV at the LHC. The results are based on data corresponding to an integrated luminosity of \(4.6 fb^{−1}\), collected with the ATLAS detector. The measurement probes the QCD sector of the Standard Model at high energy, in a region where b-quark mass and double parton scattering play an important role. In addition, the measurement is relevant for searches for physics beyond the Standard Model in final states with a W boson and b-jets. The measurement relies on the leptonic decay modes of the W, and on the iden- tification of b-jets. The backgrounds to the W+b-jets process are estimated using Monte Carlo simulation and data-driven techniques. Cross-sections, corrected for all known detector effects and quoted in a limited kinematic range, are presented as a function of jet multiplicity and of the transverse momentum of the leading b-jet for both the muon and electron decay modes of the W boson.
Physics
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Berwick, Daniel. "The identification of novel substrates of protein kinase B". Thesis, University of Bristol, 2003. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.274824.

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18

Durieux, Sandrine Spik Geneviève. "Identification de quelques rôles neurobiologiques de la cyclophiline B". [S.l.] : [s.n.], 2001. http://www.univ-lille1.fr/bustl-grisemine/pdf/extheses/50376-2001-89-90.pdf.

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Thèse de doctorat : Sciences de la vie et de la santé : Lille 1 : 2001.
Résumés en français et en anglais. Textes en français et en anglais (publications). Bibliogr. f. 213-247. Notes bibliogr.
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Durieux, Sandrine. "Identification de quelques rôles neurobiologiques de la cyclophiline B". Lille 1, 2001. https://pepite-depot.univ-lille.fr/LIBRE/Th_Num/2001/50376-2001-89-90.pdf.

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La cyclophiline B (CyPB) est une protéine dont l'origine cérébrale peut provenir d'une synthèse in situ et d'une transcytose à travers la barrière hémato-encéphalique. Afin de caractériser les cellules cérébrales capables de la synthétiser, 3 lignées cellulaires établies ont été utilisées. Nous avons ainsi montré que la CyPB est exprimée de façon constitutive dans les cellules neuronales SH-SY5Y et astrocytaires CCF-STTG1 et est inductible dans la lignée microgliale CHME3. La protéine est sécrétée par les astrocytes traités à la cyclosporine A et par les cellules microgliales après un stress oxydatif. Des sites de fixation de type protéoglycanne ont été caractérisés sur les cellules CCF-STTG1 (haute affinité) et SH-SY5Y (basse affinité). Ces dernières expriment, en plus, un récepteur fonctionnel qui permet à la CyPB d'augmenter l'adhésion des cellules SH-SY5Y sur collagènes et fibronectine par un mécanisme intracellulaire renforçant l'affinité des intégrines de type b1. Cet effet modulateur suggère que la CyPB puisse agir sur la migration cellulaire. La protéine accroît, en effet, la migration in vitro des cellules embryonnaires de crête neurale de souris. La présence de CyPB sécrétée dans le milieu de culture montrerait un mode d'action autocrine. L'expression différentielle de la CyPB dans les différents stades et régions embryonnaires indique que la protéine agirait comme une molécule "facilitatrice" de la migration. Enfin, la CyPB augmente la croissance neuritique des cellules PC12 de phéochromocytomes en présence de NGF. L'interaction de la protéine avec un récepteur fonctionnel, caractérisé sur ces cellules, permet une suractivation des protéines ERKs de la voie des MAP kinases, suggérant que la CyPB agisse comme un co-facteur stimulateur du NGF.
20

Martins, Daniel Ferreira. "Identification of horizontal gene transfer events in B. xylophilus". Master's thesis, Universidade de Aveiro, 2012. http://hdl.handle.net/10773/10163.

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Mestrado em Biotecnologia Molecular
A doença da murchidão do pinheiro foi identificada pela primeira vez no Japão em 1905 e foi associada ao nemátodo Bursaphelenchus xylophilus em 1972. A devastação provocada por esta doença, assim como as perdas económicas a ela associadas e o impacto na fileira florestal levaram a Organização Europeia para a Proteção das Plantas a declarar o nemátodo da madeira do pinheiro como uma praga. Atualmente já existe informação extensa sobre a morfologia, ciclo de vida, associação com um vetor e potenciais hospedeiros para este organismo. No entanto, o mecanismo molecular da doença é pouco conhecido, mas um dos fatores apontados, passa pela aquisição de novas funções por incorporação horizontal de genes. O transcriptoma de B. xylophilus foi sequenciado e anotado recentemente no Biocant, gerando um grande volume de dados. O objetivo do nosso trabalho foi identificar novos genes incorporados no genoma do nemátodo por transferência horizontal. Para levar a cabo esta tarefa, foi estabelecido um pipeline de análise de dados contendo um conjunto sequencial de filtros usados para remover genes com origem em nemátodos e reter os de origem bacteriana ou fúngica. Os transcritos de B. xylophilus anotados foram também filtrados de acordo com as funções dos genes e pelo E-value. Uma última filtragem foi realizada tendo por base a composição da comunidade microbiana associada ao nemátodo, obtida por pirosequenciação. O pipeline definido gerou 21 candidatos que foram validados através de análise filogenética com proteínas homólogas de bactérias, fungos, nemátodos e outros organismos e ainda com uma posterior identificação do gene no genoma do nemátodo, disponibilizado no decurso deste trabalho. Esta abordagem identificou três genes incorporados por transferência horizontal: uma β-1,3-endoglucanase, uma álcool desidrogenase, e um gene que pertence à família das desidrogenases/redutases de cadeia curta. Os primeiros dois genes já foram descritos em B. xylophilus e C. elegans, respetivamente, o que valida a nossa abordagem. O papel que o gene recém-identificado desempenha no nemátodo e na doença terá de ser estudado futuramente, na expectativa deste fornecer novas informações sobre o mecanismo da doença e novos alvos elegíveis para o controlo da doença.
Pine wilt disease was first identified in Japan in 1905 and its association with the nematode Bursaphelenchus xylophilus dates back to 1972. The devastating nature of this disease and the big economical losses it generates along with the ecological impact led the European Plant Protection Organization to consider its causal agent as an european quarantine pest. Until now, information regarding the nature of B. xylophilus with reference to its morphological characters, life cycle, vector association and potential host have been gathered and documented. However, little is known on the molecular mechanisms of the disease. According to current knowledge one of the factors that may play a role in the disease is the acquisition of new gene functions through horizontal gene transfer (HGT). The transcriptome of B. xylophilus was recently sequenced and annotated at Biocant, providing a large amount of genomics information. The goal of our work was to identify new genes incorporated through HGT in these transcripts. To accomplish our objective we established a data analysis pipeline composed of several filters to discard genes of nematodal origin and select only those of bacterial or fungal origin. B. xylophilus transcripts were screened based on the information held in their annotation: E-value, organism origin and existence of a specific function. A final screen was performed by removing all hits matching the microbial community associated with the nematode, as determined by barcoded pyrosequencing. The pipeline outlined 21 candidates that were compared to homologous sequences from bacteria, fungi, nematodes and other organisms through phylogenetic analysis. This last step confirmed the presence of three genes resulting from HGT a β-1,3- endoglucanase, an alcohol dehydrogenase and a short chain dehydrogenase/reductase. The first two genes were already described for B. xylophilus and C. elegans, respectively, validating our approach. The role of the newly identified HGT gene in the nematode and disease will be studied in the future, expecting to provide new information on the disease mechanism and contribute to the identification of new targets eligible for disease control.
21

Odhar, Hasanain. "Identification of novel scaffolds for Monoamine oxidase B inhibitors". Kent State University / OhioLINK, 2014. http://rave.ohiolink.edu/etdc/view?acc_num=kent1394416913.

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22

Manukyan, Narine. "Improved Methods for Cluster Identification and Visualization". ScholarWorks @ UVM, 2011. http://scholarworks.uvm.edu/graddis/147.

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Self-organizing maps (SOMs) are self-organized projections of high dimensional data onto a low, typically two dimensional (2D), map wherein vector similarity is implicitly translated into topological closeness in the 2D projection. They are thus used for clustering and visualization of high dimensional data. However it is often challenging to interpret the results due to drawbacks of currently used methods for identifying and visualizing cluster boundaries in the resulting feature maps. In this thesis we introduce a new phase to the SOM that we refer to as the Cluster Reinforcement (CR) phase. The CR phase amplifies within-cluster similarity with the consequence that cluster boundaries become much more evident. We also define a new Boundary (B) matrix that makes cluster boundaries easy to visualize, can be thresholded at various levels to make cluster hierarchies apparent, and can be overlain directly onto maps of component planes (something that was not possible with previous methods). The combination of the SOM, CR phase and B-matrix comprise an automated method for improved identification and informative visualization of clusters in high dimensional data. We demonstrate these methods on three data sets: the classic 13- dimensional binary-valued “animal” benchmark test, actual 60-dimensional binaryvalued phonetic word clustering problem, and 3-dimensional real-valued geographic data clustering related to fuel efficiency of vehicle choice.
23

Hedrick, Shannon. "IDENTIFICATION OF HUMAN PGC-1α-b ISOFORMS USING A NOVEL PGC-1α-b SPECIFIC ANTIBODY". VCU Scholars Compass, 2013. http://scholarscompass.vcu.edu/etd/3225.

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Peroxisome proliferator-activated receptor gamma coactivator 1-alpha (PGC-1α) is known as the master regulator of mitochondrial biogenesis. PGC-1α holds this role by acting as a transcriptional coactivator for an array of transcription factors and nuclear hormone receptors, such as NRF-1/2 and ERRα/γ, whose downstream targets function in mitochondrial biogenesis and oxidative phosphorylation. PGC-1α is regulated both at the transcriptional and post-translational level in several signaling pathways, including p38 MAPK and AMPK. This regulation affects which transcription factor binding events can occur in a given tissue, and thus affects regulation of PGC-1α target genes. PGC-1α is downregulated in many neurodegenerative disorders as well as in muscular dystrophies, diabetes, and aging. Therefore, PGC-1α is prized as a potential therapeutic target to create novel treatments for these various diseases.However, details governing the spatio-temporal regulation of PGC-1α are not completely understood, and overexpression of PGC-1α throughout the body or even in certain tissues or subsets of cells have had detrimental effects in animal and cell models. Therefore, it is necessary to gain knowledge of how to modulate PGC-1α in a tissue-specific manner utilizing these different levels of regulation in order to develop novel therapies. In order to further understand all the functions that have been attributed to PGC-1α, the PGC-1α isoforms need to be accounted for and understood in human tissues. Several murine isoforms have been published, as well as several human brain and muscle isoforms. However, most of these isoforms have only been validated as mature transcripts, and it is not known whether they produce functional protein. Our lab has identified the isoform b transcript in human brain tissue via 5’ RACE and have developed an isoform b specific antibody. This project aimed to characterize the isoform b transcripts and also to validate and optimize this antibody for immunoblotting conditions for detection of further PGC-1α-b isoform protein variants in human tissues. Preliminary studies in our lab have shown that in postmortem frontal cortex from age-matched PD and healthy patients, isoform a transcript levels were 10-15 times more abundant than that of isoform b. These differences in regulation could be partially attributed to the isoform b promoter region being heavily methylated, as shown in this thesis through bisulphite cloning and sequencing as well as 454 bisulphite sequence analysis. The high degree of methylation, correlated with the low level of isoform b transcript in brain and it is not known whether this transcript would be translated into protein in this tissue. In order to probe for isoform b protein expression using human cell lines and tissues, however, it was necessary to create a recombinant protein in order to have a positive control with which to optimize our novel antibody. In our previous 5’ RACE studies, an alternatively spliced PGC-1α-b transcript was found which coded for an early stop codon. This truncated isoform was called PGC-1α-b-3T1, and mature transcript was found in both human skeletal muscle and brain. For this project, PGC-1a-b-3T1 was cloned from human skeletal muscle into a bacterial expression vector to create a recombinant GST fusion protein. This protein was used to validate and optimize our PGC-1α-b specific antibody as well as to determine sensitivity and specificity. The purified recombinant protein contained 3 bands of lower molecular weight that were detected via western blot with both GST and the PGC-1α-b specific antibody. These bands were trypsin cleaved and subjected to mass spectrometry analysis, which verified that all bands detected by the PGC-1a-b specific antibody contained the epitope sequence, and thus binding was specific. This protein was then used to determine western blotting conditions and sensitivity, which is 10 ng using a 1:100 dilution of the antibody. This antibody was then used to probe SH-SY5Y WCL, a human neuroblastoma cell line. Peptide competition assay confirmed 5 PGC-1α-b specific proteins in these lysates. The sizes of these proteins matched to several murine PGC-1α-b isoforms as well as putative PGC-1α-b versions of PGC-1a-a isoforms. These findings provided the putative identities of several endogenous functional human PGC-1α-b isoforms. Mammalian overexpression vectors of these isoforms are still in development. By using this antibody and these expression vectors to further characterize these isoforms, including determining tissue specificity, more knowledge of PGC-1α will be gained. This information could then be used to develop novel, tissue specific treatments for pharmacological intervention of diseases characterized by PGC-1α misregulation.
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Mahboubi, Kambiz. "ATLAS level-1 jet trigger rates and study of the ATLAS discovery potential of the neutral MSSM Higgs bosons in b-jet decay channels". [S.l. : s.n.], 2001. http://deposit.ddb.de/cgi-bin/dokserv?idn=961739746.

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25

Seddigh-Tonekaboni, Siamak. "Hepatitis B virus 'S' gene variants : identification, expression and characterisation". Thesis, Imperial College London, 1999. http://hdl.handle.net/10044/1/8612.

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26

Ott, Célestin. "Caractérisation dynamique d'actionneurs fluidiques, et identification expérimentale des mécanismes dynamiques d'interaction jet - couche limite induits". Thesis, Valenciennes, Université Polytechnique Hauts-de-France, 2020. http://www.theses.fr/2020UPHF0001.

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Le contrôle actif des écoulements est un domaine de recherche à fort potentiel applicatif. Notamment dans le domaine des transports où les problématiques ayant trait à l’amélioration des performances et à la diminution de la consommation énergétique représentent des enjeux économiques et environnementaux majeurs. Dans ce contexte, l’un des objectifs consiste à optimiser les solutions de contrôle afin d’assurer un bilan énergétique global favorable. Nous proposons dans le cadre de cette thèse de s’attaquer à la question du choix des actionneurs fluidiques (classiquement fait par essai-erreur) en affinant la compréhension de la dynamique d’interaction entre l’actionneur et l’écoulement à contrôler. Pour ce faire nous avons analysé la dynamique d’interaction entre une couche limite turbulente et quatre types d’actionneurs les plus utilisés en contrôle d’écoulements : continu, pulsé, synthétique et balayant. Ainsi, sur la base de mesures de vitesse locale résolue en temps, une méthodologie de reconstruction tridimensionnelle est développée, permettant de restituer la dynamique des écoulements. Celle-ci est basée sur deux approches, l’une faisant intervenir un traitement conditionnel et l’autre un réseau de neurones. Ces méthodes permettent de caractériser la dynamique intrinsèque des écoulements induits par les actionneurs, mais également celle de leurs interactions avec l’écoulement de couche limite à contrôler. Ces caractérisations permettent de mettre en évidence les phénomènes physiques mis en jeu ainsi que les mécanismes de contrôle qui leur sont associés. Ces résultats pourront être utilisés dans de futures études de contrôle d’écoulements afin d’optimiser le choix d’un actionneur fluidique en fonction de la configuration et de l’objectif de contrôle
Active flow control research field has high application potential, particularly in the transportation industry, where improving performance while reducing energy consumption represents major economic and environmental challenges. In this context, one of the objectives is to optimize control solutions to ensure a favorable global energy balance. In this thesis, we propose to tackle the question of the actuator choice (conventionally done by trial-and-error) by sharpening the understanding of the dynamic interaction between the actuator and the external flow. To do this, we analyzed the dynamic interaction between a turbulent boundary layer and four types of actuators commonly used in flow control : continuous, pulsed, synthetic and sweeping jet actuators. Thus, a three-dimensional reconstruction methodology based on local time-resolved velocity measurements is developed, which enabled to restore the flow dynamics. This methodology is based on two approaches : one, involving conditional processing, and the other, involving neural networks. These methods enabled the characterization of the intrinsic dynamic of the flow induced by the actuators, as well as the dynamic of their interactions with a turbulent boundary layer. Thanks to these characterizations, the physical phenomena involved were highlighted, as well as the control mechanisms associated with them. These results can be used in future flow control studies to optimize the choice of fluid actuators, based on the configuration and the control objective
27

Groza, Vladimir. "Identification de paramètres et analyses de sensibilité pour un modèle d'usinage par jet d'eau abrasif". Thesis, Université Côte d'Azur (ComUE), 2016. http://www.theses.fr/2016AZUR4094/document.

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Ce travail fait partie du projet Marie-Curie ITN STEEP, dans le domaine des faisceaux énergétiques. Nous étudions ici l'identification de paramètres pour un modèle générique d'usinage par jet d'eau abrasif. L'étude de ce problème trouve son origine dans les applications industrielles d'usinage, où la nécessité de modéliser et prédire la surface finale avec une très grande précision est essentielle en l'absence de connaissance des paramètres du modèle Nous proposons ici une méthode d'identification des paramètres du modèle basée sur la minimisation d'une fonction coût, mesurant la différence entre la solution numérique et les observations expérimentales. L'approche variationnelle, basée sur le Lagrangien, permet de considérer l'adjoint, et l'utilisation d'un logiciel de différentiation automatique (TAPENADE) conduit à une identification rapide et précise des paramètres, quelles que soient la complexité et la taille du problème étudié. La qualité de l'identification peut être fortement instable et dépendre largement des données expérimentales en cas de bruit. Nous introduisons alors des termes de régularisation permettant de gérer la présence d'erreurs de mesure. Plusieurs cas d'usinage par jet abrasif sont considérés: problème stationnaire, jet qui se déplace à vitesse constante, ou en accélérant, utilisation synthétiques ou réelles L'étude de sensibilité montre la robustesse de l'approche, qui permet d'obtenir de très bons résultats acceptables d'un point de vue industriel
This work is part of STEEP Marie-Curie ITN project, covering the research in field of energy beam processing. We focus on the identification of unknown parameters of the proposed generic Abrasive WaterJet Milling (AWJM) model. The necessity of studying this problem comes from the industrial milling applications where the possibility to predict and model the final surface with high accuracy is one of the primary tasks in the absence of any knowledge of the model parameters that should be used. We propose the method of the model parameters identification by minimizing a cost function, measuring the difference between experimental observation and numerical solution. The variational approach based on corresponding Lagrangian allows to obtain the adjoint state and the involvement of the automatic differentiation software tool (TAPENADE) leads to fast and efficient parameters identification. In fact the parameter identification problem is highly unstable and strictly depends on quality of input data. Regularization terms could be effectively used to deal with the presence of measurement errors. Various cases of the AWJM process such as a stationary problem and moving with constant feed speed or acceleration are studied based on both artificial and real experimental data. The sensitivity study related to these particular problems demonstrates the strong capability of the proposed approach to obtain acceptable
28

Riveline, Michael. "Probing the parton evolution in DIS at low x[subscript]B[subscript]J using jet observables". Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1999. http://www.collectionscanada.ca/obj/s4/f2/dsk1/tape9/PQDD_0026/NQ50298.pdf.

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29

Davey, John William. "Identification of b-catenin and other RNAs in developing thalamic axons". Thesis, University of Edinburgh, 2009. http://hdl.handle.net/1842/4011.

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This thesis provides evidence for the presence of multiple RNAs in the axons and growth cones of developing thalamic cells, particularly the mRNA for the cell adhesion and Wnt-signalling-related molecule b-catenin. After many decades of effort, mRNAs have been shown to be present in the axons of many different systems in recent years. Furthermore, these mRNAs have been shown to be locally translated at the growth cone, and this local translation is required for axons to turn in response to multiple guidance cues. As studies accumulate, it is becoming clear that different axonal systems contain different complements of mRNAs and have different requirements for local translation. One axonal system which has not been investigated to date is the thalamocortical tract. The nuclei of the thalamus are connected to the areas of the cortex via bundles of axons which travel from the thalamus to the cortex via the ventral telencephalon during embyronic development. These axons make a number of turns and are guided by many cues and other axonal tracts before innervating their cortical target. In this thesis, a quantitative real-time polymerase chain reaction (qRT-PCR) approach is developed to isolate multiple mRNAs from developing thalamic axons in vitro, including b-catenin mRNA, b-actin mRNA, 18S ribosomal RNA and ten other mRNAs. The method used should be suitable for use with other axonal systems and also for testing the effect of guidance cues on mRNA expression in axons. The qRT-PCR results for b-catenin, b-actin and 18S have been validated using in situ hybridisation. Analysis of in situ hybridisation results indicates that b-catenin and 18S, but not b-actin, are upregulated in the growth cone compared to the axon. As b-catenin has been shown to be involved in axon guidance via Slit and ephrin guidance cues in other axonal systems, and these guidance cues act upon thalamocortical axons, the identification of b-catenin mRNA in thalamic axons is an important step towards a full understanding of the thalamocortical system. The results presented here indicate that local protein synthesis is likely to occur in thalamic axons as it does in other axonal systems, and that local translation is likely to be important for thalamic axonal responses to guidance cues and other axonal tracts.
30

Chambon, Philippe. "Identification retrospective des streptocoques : streptocoques du groupe b, pneumocoques, enterocoques exclus". Toulouse 3, 1988. http://www.theses.fr/1988TOU31214.

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31

Ferro, Cristina. "Mesure de la section efficace de production de paires de quarks top dans le canal tau+jets dans l'expérience CMS auprès du LHC". Phd thesis, Université de Strasbourg, 2012. http://tel.archives-ouvertes.fr/tel-00862736.

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Cette thèse a pour sujet la mesure de la section efficace de production de paires de quarks top-antitop dans l'expérience CMS auprès du LHC. L'état final considéré est le canal semi-leptonique "tau+jets". Un boson W issu de la désintégration du quark top se désintègre en un tau hadronique et neutrino tandis que le second boson W se désintègre en une paire quark-antiquark. La conduite de cette analyse a nécessité le développement d'un nouveau mode de déclenchement des données (trigger) incluant la présence de quatre jets dont un identifié en tant que tau hadronique. La configuration de ce trigger ainsi que son efficacité ont été étudiés dans cette thèse. Un échantillon de données correspondant à 3.9 fb−1 a été enregistré avec ce trigger et analysé. Les leptons taus ont été reconstruits grâce à un algorithme identifiant leurs résonances intermédiaires tandis que les jets de quarks beaux issus de la désintégration des quarks tops ont été identifiés grâce à l'algorithme "probabilité par jet". Cet algorithme pour lequel j'ai mis en oeuvre une procédure de calibration depuis 2009 utilise le paramètre d'impact des traces de particules chargées pour calculer leur probabilité de venir du vertex primaire. Des études de performance de cet algorithme sont également présentées dans cette thèse. Afin de séparer le signal de l'important bruit de fond majoritairement constitué des processus multijets QCD et W+jets un réseau de neurones utilisant des variables dites d'environnement (aplanarité, HT, M(τ,jets), énergie transverse manquante...) a été développé. La section efficace a été extraite à l'aide d'un ajustement par méthode du maximum de vraisemblance de la sortie du réseau de neurones. Les incertitudes systématiques ont fait l'objet d'une étude détaillée. La valeur de la section efficace mesurée, σ(top-antitop) = 156 ± 12 (stat.) ± 33 (syst.) ± 3 (lumi) pb, est en accord avec la section efficace prédite par le modèle standard.
32

Hatzenbuehler, Mark A. "Modeling of jet vane heat-transfer characteristics and simulation of thermal response". Thesis, Monterey, California. Naval Postgraduate School, 1988. http://hdl.handle.net/10945/23314.

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Approved for public release; distribution is unlimited
The development of a dynamic computational model capable of predicting, with the requisite design certainty, the transient thermal response of jet vane thrust control systems has been undertaken. The modeling and simulation procedures utilized are based on the concept that the thermal processes associated with jet vane operation can be put into a transfer function form commonly found in the discipline of automatic controls. Well established system identification methods are employed to formulate and verify the relationships between the various gains and frequencies of the transfer function model and experimental data provided by Naval Weapons Center, China Lake.
http://archive.org/details/modelingofjetvan00hatz
Lieutenant, United States Navy
33

Fichtner, Michael [Verfasser] y Martin [Akademischer Betreuer] Trepel. "Identification of B cell antigen receptor epitopes of mantle cell lymphoma B cells / Michael Fichtner ; Betreuer: Martin Trepel". Hamburg : Staats- und Universitätsbibliothek Hamburg, 2016. http://d-nb.info/1119319889/34.

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34

Fichtner, Michael Verfasser] y Martin [Akademischer Betreuer] [Trepel. "Identification of B cell antigen receptor epitopes of mantle cell lymphoma B cells / Michael Fichtner ; Betreuer: Martin Trepel". Hamburg : Staats- und Universitätsbibliothek Hamburg, 2016. http://nbn-resolving.de/urn:nbn:de:gbv:18-81789.

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35

Presoto, Ana Elisa Ferreira. "Vitaminas do complexo B e ferro em farinhas de cereais". Universidade de São Paulo, 2006. http://www.teses.usp.br/teses/disponiveis/9/9131/tde-21112017-145753/.

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As vitaminas do complexo B e o ferro estão presentes em farinhas de cereais, alimentos amplamente consumidos pela população brasileira. O teor natural desses compostos em farinhas de cereais pode ser significativo no cálculo de uma dieta bem balanceada e o consumo de produtos industrializados enriquecidos com vitaminas do complexo B e ferro ajuda a contribuir na ingestão diária recomendada desses micronutrientes. Tabelas Mundiais de Composição de Alimentos apresentam dados incompletos das vitaminas do complexo B e do ferro em farinhas de cereais. No Brasil, a adição de ácido fólico e ferro em farinhas de milho e trigo produzidas para fins industriais é obrigatória desde 2002. Deste modo, para a adequação dos teores de rotulagem de produtos enriquecidos com vitaminas e ferro se fazem necessários o desenvolvimento e a validação de metodologias analíticas confiáveis e sensíveis para análise de vitaminas do complexo B e ferro em alimentos que apresentam tais micronutrientes em quantidades baixas, porém significativas, que correspondem aos teores naturalmente presentes. O objetivo do presente trabalho é a avaliação dos teores de sete vitaminas do complexo B (B1, B2, B6, ácido pantotênico, ácido fólico, niacina e biotina) e ferro em cinco farinhas de cereais (aveia, arroz, cevada, milho e trigo) utilizadas como matéria prima de produtos enriquecidos na indústria alimentícia, utilizando métodos validados.
Complex B vitamins and iron are present in some cereal foods, a kind of food largely consumed by Brazilian people. The total of these micronutrients can be significant at the dairy ingestion portion and in the consume of industrialized products enriched with complex B vitamins and iron contribute in the recommended dietary intake of these micronutrients. Table of food composition do not report complete data of complex B vitamins and iron in cereal flours. In Brazil, since 2002 the addition of folic acid and iron in com and wheat flours is compulsory. Therefore, to adapt the label of some products enriched with vitamins and iron, there is necessary the development and validation of analytical methods. These methods must be reliable and with enough sensitivity to analyse complex B vitamins and iron, in low concentration, wich are natural content in food. The purpose of this work is the evaluation, with validated methods, of the content of seven complex B vitamíns (B1, B2, B6, niacin, folic acid, pantothenic acid and biotin) and iron in five kinds of cereal flours (oat, rice, barley, com and wheat). These raw materiais are used in food industry in order to enrich the industrialized products.
36

Lorteau, Mathieu. "Identification et analyse des mécanismes de génération du bruit de jet à partir de résultats expérimentaux et de simulations numériques". Thesis, Paris 6, 2015. http://www.theses.fr/2015PA066060/document.

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Cette étude s’inscrit dans le domaine de la réduction du bruit des avions et plus précisément du bruit de jet représentant la première source de bruit au décollage. Les travaux de thèse consistent en l’identification et l’analyse des mécanismes de génération du bruit de jet à partir de résultats expérimentaux et de simulations numériques. La démarche a porté dans un premier temps sur l’analyse de la structure du champ de pression proche d’un jet chaud subsonique turbulent à partir de données expérimentales acquises au moyen d’une antenne azimutale de microphones. Dans un second temps, une simulation numérique par l’approche LES, avec déclenchement de la turbulence, reproduisant la configuration expérimentale a été mise en place et validée dans le but de poursuivre l’analyse des données expérimentales. L’analyse des données issues de la simulation a permis de relier, au moyen de calculs de corrélation, les comportements identifiés dans le champ proche à des ondes de pression se développant dans la couche de cisaillement et se propageant vers la fin du cône potentiel. Cette analyse a également mis en avant le caractère intermittent du rayonnement acoustique dans la direction aval, direction pour laquelle l’énergie acoustique est maximale, ce caractère intermittent provenant des structures cohérentes se développant dans la couche de cisaillement. L’analyse réalisée à partir des données de la simulation serait utilement complétée par des calculs de cohérences entre le champ aérodynamique et le champ acoustique à partir de signaux expérimentaux provenant de mesures synchronisées
This study falls within the field of aircraft noise reduction and more precisely jet noise as it represents the main noise source during take-off. The present work consists in the identification and the analysis of the jet noise source mecanisms using experimental results and numerical simulation. First, an analysis of the near field pressure of a hot subsonic turbulent jet has been done from experimental data acquired with an azimuthal array of microphones. Secondly, in order to continue the analysis, a numerical simulation using the LES approach with turbulence triggering reproducing the experimental configuration has been set up and validated. The data obtained from the simulation enable to link the highlighted behaviours in the near field to pressure waves developping in the shear layer and propagating toward the potential core end, through correlation calculations. The intermittency of the downstream acoustic radiation, i.e. the main direction of radiation, has been evidenced and related to the coherent structures developping in the shear layer. To deepen the analysis, it would be interesting for instance to calculate spectral coherence between the aerodynamic and the acoustic fields from synchronised measurements
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Lainé, Sébastien. "Identification et caractérisation de PAP22 : partenaire cellulaire de la protéine P22 du virus de l'hépatite B humaine". Versailles-St Quentin en Yvelines, 2003. http://www.theses.fr/2003VERS0040.

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L'hépatite B est encore, à ce jour, responsable de l'apparition de nombreux hépatocarcinomes. Ces derniers sont le résultat de l'hépatite chronique, caractérisée par le maintien du virus dans l'organisme. Dans le but de comprendre quel(s) mécanisme(s) est(sont) responsable(s) du développement de la chronicité, nous avons axé nos recherches sur une protéine semblant jouer un rôle dans l'établissement de la persistance virale : l'antigène " e " du VHB (HBe). Néanmoins, les mécanismes mis en jeu sont encore obscurs. A l'inverse de son rôle, la voie de biosynthèse d'HBe a été bien décrite. HBe est issue de la maturation du précurseur P25, dans la voie de sécrétion. Notre laboratoire s'est plus particulièrement intéressé au rôle de l'un des précurseurs de HBe, la protéine P22. Nous avons montré que P22 interagit spécifiquement avec une protéine cellulaire de 32 kDa, nommée PAP22 pour Protéine Associée à P22, non identifiée au début de ces travaux de thèse. Grâce à la mise au point d'un système 'interaction in vitro basé sur la sur-expression d'une protéine P22 recombinante, nous avons identifié PAP22 comme étant la protéine cellulaire gC1qR. Les études bibliographiques ont montré que gC1qR est impliquée dans différents mécanismes allant de l'épissage, à l'apoptose en passant par la régulation de la réponse immunitaire. Nous avons élaboré et testé des hypothèses quant à l'implication du complexe P22/gC1qR dans l'établissement de la persistance virale via un contrôle du niveau apoptotique cellulaire. Ainsi, nous avons démontré que ce complexe peut agir sur l'épissage de l'ARN prégénomique du VHB et ainsi contrôler la synthèse d'une protéine virale pro-apoptotique nommée HBSP. De plus, nous avons montré que gC1qR peut contrôler le niveau apoptotique cellulaire et que ce contrôle peut être régulé par la présence de la protéine P22 Ces travaux de thèse permettent d'ouvrir une nouvelle voie d'étude du rôle de l'antigène HBe, en mettant en évidence un rôle plus important de la protéine P22, que celui de simple précurseur
The HBV virus responsible for hepatitis B is still a worldwide health issue. Its ability to stay as an episome in infected cells is responsible for chronicity, which can lead to hepatocarcinoma and cirrhosis. We focused our research on the HBe antigen of HBV, which seems implicated in viral persistence. Hbe is a cleavage product of the p22 protein. We have show a specific interaction between P22 and 32kDa cellular protein we named PAP for protein associated to P22. Using an in vitro interaction assay based on over expressing recombinant P, we identified PAP22 as gClqR. Bibliographical data indicate roles of PAP22 in spicing, apoptosis and the immune response. We could demonstrate a rôle of the P22/gC1qR complex into the HBV pre-genome spicing, which, therefore, implies a control of the pro-apoptotic HBSP protein by P22/gC1qR. Moreove, we have shown thet gClqR regulates apoptosis in a p22-sensitive manner. Our data suggest a possible role of this complex in allowing viral persistence through a tight control of apoptosis. This work opens new avenues in studying HBe functions by demonstrating specific functions of P22 thet are independent from its precursor role
38

Lisniak, Stanislav. "Transverse momentum balance of b-jet pairs in PbPb collisions with the CMS experiment at the LHC". Thesis, Université Paris-Saclay (ComUE), 2016. http://www.theses.fr/2016SACLX069/document.

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Les collisions d’ions lourds à haute énergieproduisentunnouvelétatdelamatièreappelé le plasma de quarks et de gluons. Un parton traversant le plasma perds de l’énergie, en atténuant les gerbeshadroniques:c’estl’effetde"jetquenching". La dépendance du jet quenching dans la saveur du parton fournit des contraintes sur les modèles de perte d’énergie. Le déséquilibre d’une paire de jets issus de quarks b est une observable appropriée pour étudier ce phénomène. Cette thèse présente lamesure du déséquilibre en impulsion transverse des jets de b et des jets inclusifs (non-identifiés), dans des collisions PbPb a √sNN = 5.02 TeV, réalisée avecledétecteurCMSauLHCpouruneluminosité intégrée de 404 µb−1. Aucune différence n’est observée dans le jet quenching entre les jets issus de partons légers et lourds. Une analyse des résultats à l’aide d’un modèle simple de perte d’énergie est présentée
The collisions of heavy ions at high energy produce the new state of matter called the quark gluon plasma. A parton traversing the plasma loses its energy which results in the jet quenching phenomenon. The dependence of the jet quenchingonthepartonflavorprovidesconstraints the models describing energy loss. The imbalance of b-jets is a very suitable observable to study this phenomena. This dissertation presents the measurement of the transverse momentum imbalance of b-jets and inclusive (non-identified) jets in PbPb collisions at √sNN = 5.02 TeV which is performed with the CMS detector at the LHC with total integral luminosity of 404 µb−1. No significant difference in jet quenching between light and heavy flavor jets is observed. The interpretation of results with a simple model of energy loss is performed
39

Geddes, Valerie Anne. "The molecular basis of hemophilia B : identification of the defect in factor IXVancouver". Thesis, University of British Columbia, 1987. http://hdl.handle.net/2429/26260.

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Hemophilia BVancouver, is a moderately severe hereditary disorder in which the factor IX antigen is present in relatively normal amounts but the biological activity of factor IX is markedly reduced. Previous studies have demonstrated that although the patient has 62% of the normal factor IX antigen level in his plasma, he shows only 2.6% of normal factor IX procoagulant activity. In addition, radioimmunoassays have shown that epitopes on both the heavy and light chains of activated factor IX are present. These two results were taken as an indication that the molecular defect causing the hemophilia may be a point mutation involving an amino acid change in the protein. In order to identify the mutation involved, DNA was isolated from lymphocytes in a blood sample from the patient. This DNA was used to construct a genomic library in the λ vector EMBL3. One million of the resultant clones were screened with a labelled factor IX cDNA probe to identify those clones containing portions of the factor IX gene. DNA inserts from three λ clones, which together span the entire gene, were subcloned to facilitate sequence analysis of the exons and intron / exon junctions of the factor IX gene. The nucleotide sequences of the coding regions were found to match the published sequence of the normal gene, except for one nucleotide. A single mutation was found at nucleotide 31,311 of the factor IX gene (Yoshitake et al.,1985), corresponding to amino acid 397 of the mature protein. This alteration, which changes an isoleucine codon, ATA, to a threonine codon, ACA, is novel among the mutations which have been reported to cause hemophilia B. A three dimensional model of the protease domain of factor IXа, which was prepared on the basis of its homology to the pancreatic serine proteases, was examined in the vicinity of residue 397. The position of threonine 397 in this model suggests that this mutation could alter the hydrogen bonding between factor IXа and its substrate, factor X. Taken together, these data suggest that this mutation is the cause of the hemophilia in this patient.
Medicine, Faculty of
Medical Genetics, Department of
Graduate
40

Mallery, Donna Louise. "The identification and analysis of mutation in the Cockayne Syndrome B gene". Thesis, Open University, 1999. http://oro.open.ac.uk/57982/.

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Cockayne Syndrome (CS) is a rare autosomal recessive disorder characterised by neurodegeneration, dwarfism and at least three of the following; hearing loss, dental caries, pigmentary retinopathy, characteristic facial appearance and photosensitivity. Cells from CS patients fail to recover RNA synthesis after irradiation and exhibit a loss of transcription-coupled repair, with overall genome repair being unaffected. There are two genetic complementation groups of CS alone, A and B, with the majority of patients belonging to group B. The genes defective in each of the complementation groups have been cloned, the CSA gene in 1995 and CSB in 1990. For the purposes of this study the CSB gene was sequenced in patients from complementation group B, in an attempt to identify the causative mutations. The analysis of thirteen patients from different backgrounds has revealed a wide variety of mutations in the CSB gene. A considerable number of the mutations found in CS-B patients resulted in severely truncated products. Several patients possessed two alleles affected in this way and it is unlikely that any functional protein is produced, confirming that CSB is a nonessential gene. The mutations identified did not reveal any regions within the gene that could be termed as hotspots. There was, however a tendency for the mutations to be located towards the 3' two thirds of the gene, indicated by the clustering of the mutations in this region. The severity of the mutation does not however correlate with the site or type of mutation. Clustering of the mutations towards the 3' end and the high levels of conservation in the central part of the gene prompted a study into the functional significance of the N- and Cterminal ends of the protein. Also, the presence of a highly acidic region of amino acids and a stretch of glycine residues led to a study of the effects of removing and replacing these regions. Removal of the glycine domain results in non-functional protein with respect to cell survival after UV irradiation, whereas the removal of seven glutamic acid residues from the acidic rich region, does not appear to have a particularly dramatic effect. Deletion of the C-terminal 25 amino acids of CSB totally destroys the repair ability of the gene. In contrast, cDNAs deleted at the N-terminus are able to at least, partially retain repair activity.
41

Alaasam, Mohammed. "Identification of novel monoamine oxidase B inhibitors from ligand based virtual screening". Kent State University / OhioLINK, 2014. http://rave.ohiolink.edu/etdc/view?acc_num=kent1405439915.

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42

Jiang, Fang. "Identification of QTLs that modify peripheral neuropathy in NOD.H2[b]-Pdcd1[-/-] mice". Kyoto University, 2009. http://hdl.handle.net/2433/126426.

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43

Gupta, Namita. "Computational Identification of B Cell Clones in High-Throughput Immunoglobulin Sequencing Data". Thesis, Yale University, 2017. http://pqdtopen.proquest.com/#viewpdf?dispub=10633249.

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Humoral immunity is driven by the expansion, somatic hypermutation, and selection of B cell clones. Each clone is the progeny of a single B cell responding to antigen. with diversified Ig receptors. The advent of next-generation sequencing technologies enables deep profiling of the Ig repertoire. This large-scale characterization provides a window into the micro-evolutionary dynamics of the adaptive immune response and has a variety of applications in basic science and clinical studies. Clonal relationships are not directly measured, but must be computationally inferred from these sequencing data. In this dissertation, we use a combination of human experimental and simulated data to characterize the performance of hierarchical clustering-based methods for partitioning sequences into clones. Our results suggest that hierarchical clustering using single linkage with nucleotide Hamming distance identifies clones with high confidence and provides a fully automated method for clonal grouping. The performance estimates we develop provide important context to interpret clonal analysis of repertoire sequencing data and allow for rigorous testing of other clonal grouping algorithms. We present the clonal grouping tool as well as other tools for advanced analyses of large-scale Ig repertoire sequencing data through a suite of utilities, Change-O. All Change-O tools utilize a common data format, which enables the seamless integration of multiple analyses into a single workflow. We then apply the Change-O suite in concert with the nucleotide coding se- quences for WNV-specific antibodies derived from single cells to identify expanded WNV-specific clones in the repertoires of recently infected subjects through quantitative Ig repertoire sequencing analysis. The method proposed in this dissertation to computationally identify B cell clones in Ig repertoire sequencing data with high confidence is made available through the Change-O suite and can be applied to provide insight into the dynamics of the adaptive immune response.

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Schoenaers, Caroline. "Mode identification in slowly pulsating subdwarf-B stars from line-profile variations". Thesis, University of Oxford, 2007. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.491972.

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In previous attempts to perform seismic modelling of pulsating subdwarf-B stars, various mode identification techniques have been used, with less success than in pulsating Main Sequence stars. In this work I investigate a method so far neglected in sdB stars, that is, mode identification from the line-profile variations caused by stellar pulsation. I present the first detailed spectrum synthesis of pulsating subdwarf-B stars, taking into account variations, due to non-radial pulsations, in radial velocity, surface temperature, surface gravity and surface normal. Time-series of synthetic spectra demonstrate line-profile variations are to be expected in pulsating subdwarf-B stars. I then present the 'synthetic moment' method, an original spectroscopic mode identification method I designed, and test it extensively on synthetic line-profile variations representative of those observed in slowly pulsating subdwarf-B stars. The 'synthetic moment' method is applied to spectroscopic data of slowly pulsating subdwarf-B stars HD 4539, EC 21324-1346 and PG 1627+017 I obtained at the South African Astronomical Observatory. For each of these stars I identify several pulsation modes, which in turn allows me to select their possible evolutionary stages. My pioneering work on spectroscopic mode identification in slowly pulsating subdwarf-B star sets the stage for a thorough analysis of all known sdB pulsators, thereby making for a better understanding of this late stage of stellar evolution.
45

Ranes, M. S. "Identification and characterisation of a novel ubiquitylation site on Cockayne’s Syndrome B". Thesis, University College London (University of London), 2014. http://discovery.ucl.ac.uk/1420956/.

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Cockayne’s Syndrome is a rare hereditary disorder that is characterised by severe neurological abnormalities, cutaneous photosensitivity, severe growth failure and premature aging. The aetiology of this disorder is attributed to mutations and deletions in two proteins, Cockayne’s Syndrome A (CSA) and Cockayne’s Syndrome B (CSB). Both proteins are essential in Transcription-Coupled Nucleotide Excision Repair (TC-NER), a highly specialised pathway that rapidly removes transcription-blocking DNA lesions from the transcribed strand of active genes. Besides a role in TC-NER, CSB has an additional function in general transcription, and both CSA and CSB have been implicated in the repair of oxidative DNA lesions. CSB is known to be ubiquitylated by the CSA ubiquitin ligase complex and at least during TC-NER this process may be coupled to CSB proteosomal degradation. In addition, a recent study from our laboratory identified an ubiquitin-binding domain in CSB, which is essential for its function in TC-NER. The initial aim of the study described in this thesis was to characterise the functional role of protein ubiquitylation in TC-NER through the identification and characterisation of the protein that interacts with CSB’s ubiquitin-binding domain. Realising that this protein might be ubiquitylated CSB itself, an alternate approach was the identification and mutational analysis of ubiquitylation sites in CSB. The latter approach was more successful. The expression and subsequent purification of CSB from human cells facilitated the identification of six ubiquitylation sites. Unexpectedly, mutation of the ubiquitylation site at CSB’s lysine 991 gives rise to genome instability even in the absence of DNA damage. Surprisingly, the CSB K991R cells are proficient in TC-NER, but defective in transcription, and hypersensitive to oxidative damage. To the best of my knowledge, this is the first separation of function mutation described for CSB, and provides new evidence for the possible involvement of de-regulated transcription and persistent oxidative DNA damage in the aetiology of Cockayne’s Syndrome.
46

Abdulmajed, Hind Abdulrazak Yassin. "Identification of tumour associated antigens as potential targets for the immunotherapy of B-cell chronic lymphocytic leukaemia (B-CLL)". Thesis, University of Leicester, 2008. http://hdl.handle.net/2381/9157.

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B-CLL, the most common adult B-cell malignancy in USA and the western world, is characterized by the accumulation of CD5+ mature B-cells in blood, bone marrow and lymphoid tissues. Many cases require no treatment because of an indolent course, while other patients become symptomatic or develop signs of rapid progression. Treatment is usually non-curative and is directed at reducing the symptoms. However, new therapies are currently under investigation aiming to achieve a curative therapy for B-CLL. The increasing understanding of how peptide antigens are processed, transported and presented by HLA, the identification of tumour antigens recognised by cytotoxic T lymphocytes and the identification of T-cell epitopes on human tumor cells, have opened the routes for the development of more efficient strategies for tumour immunotherapy. Several antigens have been characterized as tumour associated antigens (TAA) in B-CLL, with the potential to elicit specific anti-tumour responses. This thesis addresses the role of survivin, a member of the family of inhibitor of apoptosis proteins, as a potential target for the immunotherapy of B-CLL. Data on survivin expression showed no/ little expression of survivin in resting B-CLL, which was upregulated by in vitro activation with CD40 ligation, CpG-oligodeoxynucleotides (ODN), and with both stimulators together. CD40 ligation resulted in greater B-CLL cell activation, survivin expression, upregulation of activation markers (CD54, CD80 and CD86), and in enhanced activity of B-CLL cells to stimulate allogeneic T cell proliferation, compared to the other two ways of stimulation. Studying the induction of autologous tumour specific T cell responses in vitro, CD40L activated B-CLL cells enhanced CTL responses compared to unactivated cells. No significant difference in response of B-CLL patients T cells to survivin peptide pulsed T2 cells was found between HLA-A2+ and HLA-A2- patients, and no clear peptide specific responses were seen in either group. After investigating survivin peptides for their potential to induce cytotoxic T cell responses, generating survivin specific CTL line from a healthy donor was attempted using peptide pulsed autologous monocyte derived dendritic cells, but was unsuccessful suggesting that no T cells in the culture were able to recognise survivin peptides, or that the culture conditions used were inappropriate for the generation and maintenance of such responses. Finally, in investigation of other TAA expression in B-CLL cells, no expression of MAGE-A1, MAGE-A3, Proteinase-3, WT-1 was detected pre- and post CD40 activation. Positive PRAME expression was detected in 8 out of 20 CD40L activated CLL cells whilst NY-ESO-1 showed an upregulation in one sample. Overall results indicate that much work is still needed to study the potential of immunotherapy in the treatment of B-CLL.
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Chadwick, Matthew. "Measurement of the tt̄ cross-section at 7 TeV with 36 PB⁻¹ of data in the electron+jets decay channel using the CMS detector". Thesis, Brunel University, 2012. http://bura.brunel.ac.uk/handle/2438/6498.

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A measurement of the top-pair production cross-section at a centre-of-mass energy of 7 TeV using proton-proton collisions with 36 pb-1 of data collected by CMS at the Large Hadron Collider is presented. The analysis is performed using the nal state that consists of one isolated electron with jets, one of which is required to be identified as being consistent with including the decay of a B hadron. The measured cross-section with three or more selected jets is 169 +/- 13(stat:)+37 +32(sys:)+8 -7(lumi:) pb and 197 +/- 17(stat:)+38 -35(sys:)+9 -8(lumi:) pb for four or more jets. The results are consistent with NLO and approximate NNLO theoretical predictions.
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Woods, Nathan Michael. "PHASE-LOCKED PIV INVESTIGATION OF THE EFFECTS OF THE BLOWING RATIO OF A PULSED VORTEX GENERATOR JET IN A LOW-PRESSURE TURBINE". Wright State University / OhioLINK, 2007. http://rave.ohiolink.edu/etdc/view?acc_num=wright1190066085.

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49

Woortman, Dirk Volker [Verfasser], Thomas B. [Akademischer Betreuer] Brück, Thomas B. [Gutachter] Brück y Michael [Gutachter] Rychlik. "The production of microalgae derived, functional additives for jet fuel, food and cosmetics / Dirk Volker Woortman ; Gutachter: Thomas B. Brück, Michael Rychlik ; Betreuer: Thomas B. Brück". München : Universitätsbibliothek der TU München, 2020. http://d-nb.info/121147643X/34.

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50

Lee, Guinevere Kwun Wing Queenie. "Serine/threonine phosphorylation in mycobacterium tuberculosis : identification of protein kinase B (PknB) substrates". Thesis, University of British Columbia, 2008. http://hdl.handle.net/2429/693.

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Tuberculosis, caused by the intracellular pathogen Mycobacterium tuberculosis, is one of the most prevalent infectious diseases in our world today. In order to survive within the host the bacteria need to sense and respond to changes in the environment; however, signal transduction in this bacterium is poorly understood. PknB is a serine/threonine kinase essential for the in vitro survival of M. tuberculosis and therefore a potential drug target against the bacteria. It is the goal of the current study to elucidate downstream substrates of PknB. We have found that PknB shares in vitro substrates with another serine/threonine kinase, PknH, implying the potential complexity of the signaling pathways in the bacteria. We have also provided the first description of the coupling between serine/threonine kinases PknB and PknH with a two-component system response regulator DevR, and further proposed Ser/Thr phosphorylation as the negative regulator of DevR transcription activator activity based on LC-MS/MS analysis. Finally, we have identified a previously unknown phosphoprotein glyceraldehyde 3-phosphate dehydrogenase encoded by the ORF Rv1436, which demonstrates autophosphorylation activity and which phosphorylation is independent of PknB. Overall, the current study has contributed to advance our understanding of the signal transduction pathways and phosphoproteome in Mycobacterium tuberculosis.