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Tesis sobre el tema "Immunoglobulins"

Autor: Grafiati

Publicado: 4 de junio de 2021

Última modificación: 25 de julio de 2025

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1

Das, Mrinmoy. "The regulatory effects of circulating normal immunoglobulins on autophagy and Th17 response." Thesis, Paris 6, 2017. http://www.theses.fr/2017PA066153/document.

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Les immunoglobulines circulantes jouent un rôle critique dans l’homéostasie immune en modulant les fonctions des cellules du système immunitaire. Au cours de ma thèse, j’ai exploré les effets régulateurs des immunoglobulines G thérapeutiques (IVIG) et des immunoglobulines A monomériques circulantes (mIgA) sur l’autophagie et les réponses Th17 respectivement. Les IVIg sont une préparation thérapeutique d’IgG normales poolées. Elles ont utilisées comme agent anti-inflammatoire dans le traitement de maladies auto-immunes et inflammatoires variées. Cependant, les mécanismes ne sont pas complètemen

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2

Almroth, Gabriel. "Immunoglobulins, immunoglobulin subclass-distributions and serologic markers in some renal and systemic disorders /." Linköping : Univ, 2000. http://www.bibl.liu.se/liupubl/disp/disp2000/med646s.pdf.

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3

Rogers, Kenneth Alton. "Immunoglobulins and Immunoglobulin Fc Receptors in Nonhuman Primates Commonly Used in Biomedical Research." Digital Archive @ GSU, 2006. http://digitalarchive.gsu.edu/biology_diss/6.

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Antibodies neutralize and eliminate pathogens, malignancies, and toxins by acting either alone or in association with Fc receptors which, once engaged, activate the elimination mechanisms of phagocytic cells. Based on structural differences, antibodies are divided into functionally distinct classes (IgM, IgD, IgG, IgE and IgA). Structure-function relationships within these classes are not well characterized. In addition, animal models for the assessment of potential therapeutic strategies for the modulation of the interaction between antibodies and Fc receptors are not established. Nonhuman pr

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4

Teng, Su Fern. "Immunoglobulins binding ligands." Thesis, University of Cambridge, 1997. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.627345.

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5

Ding, Cheng. "Siglec-G is a negative regulator of NF-[kappa]B activation and has pivotal roles in B-1 cell development and resistance to sepsis /." Columbus, Ohio : Ohio State University, 2008. http://rave.ohiolink.edu/etdc/view?acc%5Fnum=osu1226876722.

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6

Smith, David G. E. "Activities of anti-lipopolysaccharide immunoglobulins." Thesis, University of Edinburgh, 1989. http://hdl.handle.net/1842/19300.

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7

Barua, Utpal. "Allergen specific immunoglobulins during pregnancy." Thesis, Sheffield Hallam University, 1993. http://shura.shu.ac.uk/19325/.

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In this study the serum concentration of IgE and IgG4 (total and allergen specific taking Timothy grass pollen as the model allergen) have been investigated prospectively during and after pregnancy in healthy women and women suffering from allergic rhinitis. The results show that the total serum IgG concentration remained unchanged in both groups during pregnancy. There was no significant difference in the serum concentration of IgG 4 between pregnant allergic women and non-pregnant allergic women. Levels of IgG4 were approximately twice as high (p< 0.01) in non-allergic pregnant women compare

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8

Jeffrey, Philip D. "The structure and specificity of immunoglobulins." Thesis, University of Oxford, 1989. http://ora.ox.ac.uk/objects/uuid:79bcae45-289d-4401-9916-d719bc2751a4.

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An investigation into the structures of the antigen-binding fragments (Fab) of mouse monoclonal immunoglobulins by X-ray crystallography, is presented. The family of immunoglobulins studied, Gloops 1-5, possess the ability to bind to both the peptide antigen and the parent protein: Hen Egg-white Lysozyme. The Gloop1 and Gloop4 Fabs were generated by proteolytic cleavage of the antibody, and crystallisation trials yielded crystals of uncomplexed Fabs of both species. Attempts to grow Fab:antigen complex crystals proved unsuccessful. Partial purification of the heterogeneous Gloop4 Fab was found

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9

Prinsloo, Earl Adin Gerard. "An investigation of the binding capacities of recombinant domain mutants of the human Polymeric Immunoglobulin Receptor (pIgR)." Thesis, Nelson Mandela Metropolitan University, 2006. http://hdl.handle.net/10948/403.

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The membrane bound glycoprotein, polymeric immunoglobulin receptor (pIgR) is the primary transport molecule of the polymeric immunoglobulins, dimeric IgA and pentameric IgM, across epithelial cells. This process, known as transcytosis, is essential in order to establish immunity at mucosal surfaces. Typically, pIgR binds to the polymeric immunoglobulin at the basolateral surface of the epithelial cell, via five homologous immunoglobulin-like domains of the ectodomain. Binding is covalent to IgA and non-covalent to IgM; the IgM binding varying among species. The pIgR-bound complex is released a

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10

李瑞山 and Shui-shan Lee. "Anti-neutrophil cytoplasmic antibody: a clinical & experimental study." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 1993. http://hub.hku.hk/bib/B31981513.

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11

Lee, Shui-shan. "Anti-neutrophil cytoplasmic antibody : a clinical & experimental study /." [Hong Kong : University of Hong Kong], 1993. http://sunzi.lib.hku.hk/hkuto/record.jsp?B13762679.

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12

Hirano, Ayumi. "T dependent B cell help in cattle : immunoregulatory function of interleukin-4 and CD40-CD40L interactions /." free to MU campus, to others for purchase, 1997. http://wwwlib.umi.com/cr/mo/fullcit?p9841150.

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13

Rodríguez, Lobato Luis Gerardo. "Factores pronósticos en pacientes con amiloidosis sistémica por cadenas ligeras." Doctoral thesis, Universitat de Barcelona, 2018. http://hdl.handle.net/10803/663901.

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La amiloidosis de cadenas ligeras (AL) es una neoplasia rara, que se caracteriza por la presencia de células plasmáticas (CP) clonales en la médula ósea (MO), las cuales producen una inmunoglobulina (Ig) de cadena ligera monoclonal frecuentemente de isotipo lambda. Las Ig de cadena ligera amiloidogénicas se agregan y se depositan en el tejido como fibrillas de amiloide. La presentación clínica es muy heterogénea y el diagnóstico requiere una alto índice de sospecha. El pronóstico depende principalmente del órgano afecto, así como del tamaño y biología de la CP clonal. El objetivo del tratamien

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14

Didriksen, Nancy A. (Nancy Andrews). "Psychological Stress: Effect on Humoral Immune Functioning as Measured by Immunoglobulin Levels." Thesis, North Texas State University, 1986. https://digital.library.unt.edu/ark:/67531/metadc331278/.

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The purpose of the present study was to determine if psychological stress, defined as academic examination stress, would systematically produce changes in immune parameters (immunoglobulin concentration) and psychological functioning. It was hypothesized that as examination stress occurred there would be an effect on immunological function consistent with heightened psychological activity/stress. Subjects were 23 master's and doctoral students in psychology who volunteered for the research project. All subjects were administered a series of psychological tests to measure stress, personality fa

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15

Laurencikiene, Jurga. "Regulation of germline transcription in the immunoglobulin heavy chain locus /." Stockholm, 2004. http://diss.kib.ki.se/2004/91-7349-989-7/.

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16

Mohamed, Alahlafi Abdelaziz H. "The significance of immune reactants deposited in the basement membrane zone of the skin in patients with lupus erythematosus." Thesis, University of Oxford, 2003. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.275408.

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17

Head, Jared G. "Structure and function of the #beta#-sheet proteins, titin and CD2." Thesis, University of Bristol, 1998. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.265387.

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18

Costello, Mark Eugene. "Growth and productivity of hybridoma cell lines in vitro." Thesis, Manchester Metropolitan University, 1990. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.280629.

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19

Davies, Julian. "Antibody VH domains as small recognition units." Thesis, University of Cambridge, 1995. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.263483.

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20

Kwong, Wai-ip Eric. "Development of an in-house anti-Ro52 ELISA and a study of the clinical applications of anti-Ro52 in rheumatic diseases." Click to view the E-thesis via HKUTO, 2009. http://sunzi.lib.hku.hk/hkuto/record/B42925009.

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21

Ng, Kin-man. "Application of p63 4A4 antibody in detection of cervical cancer and precursors in cytology samples." Click to view the E-thesis via HKUTO, 2009. http://sunzi.lib.hku.hk/hkuto/record/B42905357.

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22

Engström, Gunilla Norhagen. "Mucosal conditions in immunodeficient individuals with special emphasis on salivary immunoglobulins." Stockholm : Department of Clinical Immunology, and the Department of Periodontology, Karolinska Institutet, 1993. http://catalog.hathitrust.org/api/volumes/oclc/28436070.html.

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23

Low, Douglas Graham. "NMR investigation of molecular contacts in a hapten-antibody complex." Thesis, University of St Andrews, 1996. http://hdl.handle.net/10023/13986.

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An antibody Fv fragment was cloned from hybridoma cells of a monoclonal antibody against the steroid derivative estrone-3-glucuronide (E3G). The detection of this molecule is important in a method for predicting fertility. The variable heavy and light chain genes were isolated and amplified and placed into a modified pUC 19 vector to allow expression of active protein. The immunochemistry of the fragment was determined by ELISA, demonstrating that the fragment did bind E3G, that this binding was specific, the antibody fragment competed against the parent monoclonal antibody, and that the fragm

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24

Stephens, Lauren Ellis. "Interaction of immunoglobulins with primate Fc[gamma]RIIIa." Thesis, University of Cambridge, 2014. https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.708276.

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25

Al-Lazikani, Bissan. "Canonical structures of immunoglobulins and T cell receptors." Thesis, University of Cambridge, 1999. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.624098.

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26

Krick, Kari Elizabeth. "Exercise and Immunodeficiency Affect Immunoglobulins in Endurance Horses." Thesis, Virginia Tech, 2002. http://hdl.handle.net/10919/43971.

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Two studies were conducted on endurance horses predominantly of Arabian breeding participating in an 80 km ride dedicated to research in April 2001 (Trial 1) and April 2002 (Trial 2). Objectives were to determine effects of endurance exercise, antioxidant supplementation, and a feed rich in fiber and fat vs. a high fat sweet feed on immunoglobulin A and G concentrations as well as identify selective IgA deficiency in endurance horses of Arabian breeding. There were no effects of distance in Trial 1 on IgA (P = 0.73) or IgG (P = 0.18) concentrations. In Trial 2, IgA concentrations increased

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27

Velez, Maria-Gabriela. "Development and function of allelically included B cells /." Connect to full text via ProQuest. Limited to UCD Anschutz Medical Campus, 2008.

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Thesis (Ph.D. in Immunology) -- University of Colorado Denver, 2008.<br>Typescript. Includes bibliographical references (leaves 153-162). Free to UCD Anschutz Medical Campus. Online version available via ProQuest Digital Dissertations;

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28

Martinez-Rivas, Gemma. "Exploration des mécanismes physiopathologiques de l'amylose et évaluation des nouvelles approches thérapeutiques." Electronic Thesis or Diss., Limoges, 2024. http://www.theses.fr/2024LIMO0052.

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L’amylose à chaînes légères (AL) est l’une des formes les plus courantes d’amylose systémique, provoquée par le dépôt de chaînes légères (LC) d’immunoglobulines (Ig) sous forme de fibrilles amyloïdes dans les tissus, entraînant une dysfonction organique. Les formes les plus fréquentes et sévères affectent les reins et le cœur, cette dernière étant associée à un mauvais pronostic. Malgré des efforts considérables pour comprendre les mécanismes de formation des fibrilles et leur toxicité, l’absence de modèles in vivo fiables entrave l’étude de la maladie dans son contexte physiologique. Cette th

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29

Arasteh, Nikoo. "Passive immunization of rainbow trout with chicken immunoglobulins (IgY)." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 2000. http://www.collectionscanada.ca/obj/s4/f2/dsk1/tape2/PQDD_0011/NQ56496.pdf.

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30

Galens, Kevin. "Knowledge based structure modeling of the third hypervariable region of antibodies /." Link to online version, 2006. https://ritdml.rit.edu/dspace/handle/1850/1877.

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31

Van, Zyl Dwain George. "Production of recombinant human CD21 and CD23 : towards a better understanding of their interaction." Thesis, Nelson Mandela Metropolitan University, 2013. http://hdl.handle.net/10948/d10211135.

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The prevalence of allergic diseases has dramatically increased over the last three decades. Presently, it is estimated that 20-30 per cent of the developed world suffers from allergic diseases. The majority of allergic diseases are rooted in the activities of IgE; an immunoglobulin which exerts its effector functions by interacting with a network of proteins. This network includes its low affinity receptor CD23. Cross linking of membrane IgE and CD21 by soluble CD23 results in an increase in IgE synthesis. This marks the interaction between CD23 and CD21 as an attractive therapeutic target. Ho

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32

梁子明 and Tze-ming Leung. "Immunological studies of a phosphorylcholine-specific antibody using gene transfer techniques." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 1994. http://hub.hku.hk/bib/B31233740.

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33

Kwong, Wai-ip Eric, and 鄺偉業. "Development of an in-house anti-Ro52 ELISA and a study of the clinicalapplications of anti-Ro52 in rheumatic diseases." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2009. http://hub.hku.hk/bib/B42925009.

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34

Upton, I. "The immune response of the pig to infections with Steptococcus suis type II." Thesis, University of Cambridge, 1986. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.377260.

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35

Bidgood, Susanna Ruth. "Antibody mediated intracellular immunity." Thesis, University of Cambridge, 2013. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.648288.

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36

Wright, Deborah Emma. "A study into the effect of antibody on murine gammaherpesvirus 68 replication." Thesis, University of Cambridge, 2011. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.609834.

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37

Leung, Tze-ming. "Immunological studies of a phosphorylcholine-specific antibody using gene transfer techniques /." [Hong Kong] : University of Hong Kong, 1994. http://sunzi.lib.hku.hk/hkuto/record.jsp?B13762680.

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38

Engström, Per-Erik. "Mucosal and systemic antibody networks with special emphasis on IgA subclasses." Stockholm : Department of Clinical Immunology and the Department of Periodontology, Karolinska Institute, 1993. http://catalog.hathitrust.org/api/volumes/oclc/28436118.html.

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39

Dooley, Helen. "Characterisation of single domain antibody fragments from the nurse shark Ginglymostoma cirratum, using phage display." Thesis, University of Aberdeen, 2001. http://digitool.abdn.ac.uk:80/webclient/DeliveryManager?pid=219953.

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40

Navarro, López Alba. "Estudi de l'estat mutacional dels gens de les immunoglobulines i heterogeneïtat clínico biològica del linfoma de les cèl•lules del mantell." Doctoral thesis, Universitat de Barcelona, 2012. http://hdl.handle.net/10803/91069.

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El limfoma de cèl•lules del mantell (LCM) és una neoplàsia heterogènia en relació a les característiques clíniques, biològiques i moleculars que presenten els pacients. La morfologia, l’immunofenotip i el genotip no són suficients per explicar aquesta gran diversitat. Encara que es considera una neoplàsia agressiva alguns pacients segueixen un curs clínic indolent sense la necessitat de tractament en el moment del diagnòstic i presenten una supervivència llarga. Els resultats d’aquesta tesi demostren que els LCM amb elevada càrrega mutacional en els gens de les immunoglobulines (IGHV)(<97%

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41

Fernández, Codina Andreu. "Malaltia relacionada amb la IgG4." Doctoral thesis, Universitat Autònoma de Barcelona, 2019. http://hdl.handle.net/10803/667368.

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La malaltia relacionada amb la IgG4 (IgG4-RD) és una patologia fibroinflamatòria autoimmune sistèmica, caracteritzada pel desenvolupament de masses fibròtiques que poden portar a l’alteració de l’arquitectura dels teixits i a la disfunció orgànica. En aquesta tesi doctoral s’ha estudiat per primera vegada aquesta malaltia a Espanya, creant un registre nacional, basat en els criteris de consens internacional en patologia en IgG4-RD. El primer estudi ha mostrat que els pacients amb IgG4-RD han estat predominantment homes d’edat mitjana. La malaltia va afectar múltiples òrgans en un 47% de

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42

Benadda, Samira. "Le rôle du système endosomal dans la fonction des récepteurs activateurs aux fragments Fc des immnunoglobulines : exemples du RFcyI." Thesis, Université de Paris (2019-....), 2019. http://www.theses.fr/2019UNIP7075.

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Les Récepteurs aux fragments Fcs des immunoglobulines (RFcs) sont des récepteurs majeurs du système immunitaire, présents à la surface des cellules immunes et faisant l’interface entre l’immunité innée et l’immunité adaptative. Ils reconnaissent la partie Fc des immunoglobulines des complexes immuns (IC) constitués d’un antigène et d’une immunoglobuline spécifique déclenchant des voies de signalisation qui déterminent la production de médiateurs anti- ou pro-inflammatoires ainsi que d’autres réactions permettant l’élimination de l’infection. Après la liaison de la partie Fc des ICs, le récepte

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43

Mohammed, Mansoor S. "Uptake of human immunoglobulins into the egg yolk of hens." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1999. http://www.collectionscanada.ca/obj/s4/f2/dsk1/tape8/PQDD_0004/NQ43267.pdf.

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44

Maury, Michael [Verfasser]. "Aggregation and structural changes in spray dried immunoglobulins / Michael Maury." Aachen : Shaker, 2005. http://d-nb.info/1186577290/34.

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45

Sedano, Rodolfo Canseco. "Effect of immunoglobulins on early bovine embryo development in vitro." Thesis, Virginia Tech, 1985. http://hdl.handle.net/10919/41575.

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Bovine morulae (day 6: n=257) were obtained to evaluate the [effect of immunoglobulins (Ig) on early bovine embryo development in vitro. Fifty-four cows superovulations were conducted in 36 cows with follicle stimulating hormone. Embryos were collected by non-surgical procedures and morphologically evaluated and randomly assigned to culture. Embryos were cultured in Ham's F-10 containing 10% (6.4 mg/ml) steer serum (SS), 1% (.64 mg/ml) bovine gamma . globulins (GG), 1% (.64 mg/ml) bovine IgG, 1% (.64 mg/ml) bovine 1gM, 10% SS plus 1% GG, 10% SS plus 1% 1gG, or 10% SS plus 1% 1gM. Emb

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46

Ariño, Rodríguez Helena. "Neurological syndromes associated with antibodies against the glutamic acid decarboxylase (GAD)." Doctoral thesis, Universitat de Barcelona, 2017. http://hdl.handle.net/10803/666797.

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This thesis focuses on antibodies against the glutamic acid decarboxylase (GAD-ab) in neurological disorders. GAD-ab were first identified in 1988 in the serum and CSF from one patient with stiff-person syndrome (SPS) and diabetes mellitus (T1DM). Since then, GAD-ab have become excellent biomarkers in several autoimmune conditions affecting the endocrine system, the CNS or both simultaneously. High serum GAD-ab levels have expanded the neurological spectrum and have been described in patients with cerebellar ataxia (CA), epilepsy and limbic encephalitis (LE) of autoimmune origin. Even though a

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47

Eddahri, Fouad. "Caractéristation des lymphocytes T auxiliaires impliqués dans la régulation de la réponse humorale." Doctoral thesis, Universite Libre de Bruxelles, 2007. http://hdl.handle.net/2013/ULB-DIPOT:oai:dipot.ulb.ac.be:2013/210685.

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48

Barden, Timothy John. "The synthesis of novel O-alkyl analogues of the energy-repartitioning [beta]-agonist clenbuterol and their physiological and immunological characterisations." Thesis, [Campbelltown, N.S.W. : The Author], 1995. http://handle.uws.edu.au:8081/1959.7/29572.

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It was proposed that some O-alkyl analogues of the beta-adrenergic agonist clenbuterol would be effective structural and functional congeners of clenbuterol which may then be used for the production of clenbuterol-specific idiotypic antibodies. These antibodies could possibly then be used to generate anti-idiotypic antibodies that mimic the energy-repartitioning effects of clenbuterol. Therefore, the aim of this work was to synthesise and characterise these compounds, evaluate their physiological effects, characterise the specificity of antibodies produced in response to protein conjugates of

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49

Ramsland, Paul Allen. "Variable region gene expression and structural motifs of human polyreactive immunoglobulins." University of Technology, Sydney.|bFaculty of Science, 1997. http://hdl.handle.net/2100/372.

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Polyreactive immunoglobulins (Ig) exhibit a capacity to recognise multiple, structurally dissimilar antigens through a single combining site. This characteristic differentiates these Igs from monoreactive Igs which bind to a single antigen, usually with high specificity and affinity. Chronic B lymphocytic leukaemia (B CLL) is a malignancy identified by the incessant accumulation, in the peripheral circulation, of B lymphocytes of a mature and resting morphology. B CLL malignant cells generally express both surface IgM and the pan T cell antigen CD5. Moreover, the IgM on the surface of these CD

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50

McCannel, Anne Marie. "Separation of immunoglobulins from egg yolk using metal chelate interaction chromatography and ion exchange chromatography." Thesis, University of British Columbia, 1988. http://hdl.handle.net/2429/27987.

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The immune response of chickens immunized with β-N-acetylglucosaminidase was monitored in the egg yolks of the birds using an enzyme-linked immunosorbent assay. Significantly higher levels of specific antibodies were detected in the yolks of the birds immunized with the enzyme when compared with the yolks of a control bird collected over the same period significant differences also were found in the response within the immunized group of birds, indicating individual variability to the injections. Immunoglobulins were isolated from egg yolk after a preliminary purification using alginate to pr

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