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Tesis sobre el tema "In-Cell EPR"

Autor: Grafiati

Publicado: 25 de mayo de 2024

Última modificación: 31 de julio de 2025

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1

Pierro, Annalisa. "Protein structural dynamics in bacteria via nitroxide-based SDSL-EPR spectroscopy : from method improvements to in-cell studies." Electronic Thesis or Diss., Aix-Marseille, 2021. http://theses.univ-amu.fr.lama.univ-amu.fr/211116_PIERRO_290xrxu60ryzjfl293g970fjmdnl_TH%20(1).pdf.

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L'étude des biomolécules dans leur environnement natif, la cellule, est l'un des principaux objectifs de la biologie structurale au cours de la dernière décennie. Ainsi, nous assistons à un remarquable développement des approches dites « in-cell », comme la CryoET, FRET (Förster Resonance Energy Tranfer), RMN. Parmi elles, la technique de marquage de spin couplée à la spectroscopie de Résonance Paramagnétique Electronique (SDSL-RPE) présente des caractéristiques intéressantes et avantageuses permettant de sonder la dynamique des protéines à l'intérieur des cellules. En particulier, l’utilisati

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2

Noda, Yohei. "EPR studies on molecular orientation of all-organic paramagnetic liquid crystals in a surface-stabilized liquid crystal cell." 京都大学 (Kyoto University), 2007. http://hdl.handle.net/2433/136793.

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3

ROSSI, MARTINA. "Long Noncoding RNA “EPR” controls epithelial cell proliferation by coordinating CDKN1A transcription and mRNA decay in response to TGF-β". Doctoral thesis, Università degli studi di Genova, 2019. http://hdl.handle.net/11567/936734.

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Long noncoding RNAs (lncRNAs) are emerging as regulators of fundamental biological processes. Here we report on the functional characterization of an intergenic lncRNA (lincRNA) expressed in epithelial tissues which we termed EPR (Epithelial cell Program Regulator). EPR is rapidly downregulated by TGF-β and its sustained expression largely reshapes the transcriptome, favors the acquisition of epithelial traits, and reduces cell proliferation in cultured mammary gland cells as well as in an animal model of orthotopic transplantation. EPR generates a small peptide that localizes at epithelial ce

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4

Udyaningsih-Freisleben, Seruni Kusuma. "XAS and RR Structural Analysis of Hemoglobin and EPR Spectroscopic Labelling of Red Blood Cell Membranes Isolated from Thalassemia Patients in Jakarta, Indonesia." Thesis, The University of Sydney, 2003. https://hdl.handle.net/2123/27995.

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A study on thalassemia intermedia and major patients in Jakarta was initiated to obtain a comprehensive picture of metabolic dysregulation, iron overload, oxidative stress, and cell damage. Data were collected from a group of 10 transfusion-dependent patients in an age range of 11-25 years and another group of 5 frequently transfused (for at least 15 years) patients aged 17-30 years. A third group comprises 5 patients (aged 7 to 14 years) who had not yet obtained transfusions. The 10 controls were voluntary students without diagnosis or clinical signs of thalassemia up to 30 years of age. The

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5

Fernandez, Daniel. "Cell States and Cell Fate: Statistical and Computational Models in (Epi)Genomics." Thesis, Harvard University, 2015. http://nrs.harvard.edu/urn-3:HUL.InstRepos:14226043.

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This dissertation develops and applies several statistical and computational methods to the analysis of Next Generation Sequencing (NGS) data in order to gain a better understanding of our biology. In the rest of the chapter we introduce key concepts in molecular biology, and recent technological developments that help us better understand this complex science, which, in turn, provide the foundation and motivation for the subsequent chapters. In the second chapter we present the problem of estimating gene/isoform expression at the allelic level, and different models to solve this problem. Fir

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6

Hu, Zhengqing. "Investigating a cell replacement therapy in the inner ear /." Stockholm, 2004. http://diss.kib.ki.se/2005/91-7140-170-9/.

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7

Gregory, L. G. L. "Eph-ephrin signalling in cell sorting and directional migration." Thesis, University College London (University of London), 2011. http://discovery.ucl.ac.uk/1318081/.

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An important problem in developmental biology is to understand how precise patterns of cell types are maintained during development. Eph receptor tyrosine kinases and ephrins have key roles in stabilising these patterns of cell organisation and segregation during development and can restrict the movement of cells by promoting cell repulsion. Previous work by Alexei Poliakov in the Wilkinson lab has shown that Eph-ephrin signalling leads to directional persistence of migration, and modelling suggests that this can contribute to cell segregation. In order to test experimentally the contribution

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8

Li, Lin. "Hair cell loss and repair processes in mammalian vestibular sensory epithelia." Thesis, University College London (University of London), 1997. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.266075.

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9

Omodho, Becky. "Early growth response gene (Egr) 2 and 3 control inflammatory responses of tolerant T cells." Thesis, Brunel University, 2016. http://bura.brunel.ac.uk/handle/2438/13516.

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This study investigated the role of tolerance induction in an inflammatory setting in regard to the early growth response genes Egr2 and Egr3. T cells robustly respond to pathogenic antigens during infection, but are tolerant to stimulation by self-antigens. The intrinsic mechanisms for self-tolerance in the periphery are still not clear. Egr2 and 3 are induced in tolerant T cells in response to antigen stimulation by NFAT-medicated tolerant signalling; however, their function in tolerant T cells is still unknown. The study demonstrated that Egr2 and 3, induced in tolerant T cells, are not dir

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10

Gallagher, Ewen. "The regulation of the egr-1 promoter in B cell lines." Thesis, University of Nottingham, 2000. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.341970.

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11

Fu, Yu [Verfasser]. "Cell-type specific epi-genomic studies in Arabidopsis thaliana / Yu Fu." Düsseldorf : Universitäts- und Landesbibliothek der Heinrich-Heine-Universität Düsseldorf, 2020. http://d-nb.info/1210700409/34.

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12

Sakamoto, Tatsunori. "Hair cell differentiation becomes tissue specific by E9.5 in mouse inner ear." Kyoto University, 2008. http://hdl.handle.net/2433/135785.

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13

Wang, Haoming. "Revealing the Role of Tmc2b in Hair Cell Subtypes Within the Inner Ear." Case Western Reserve University School of Graduate Studies / OhioLINK, 2021. http://rave.ohiolink.edu/etdc/view?acc_num=case1619801272628693.

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14

Hackney, Jennifer Faye Dobens Leonard L. "Ecdysone Receptor (EcR) regulates cell migration and chorion gene amplification in the drosophila ovary." Diss., UMK access, 2008.

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Thesis (Ph. D.)--School of Biological Sciences. University of Missouri--Kansas City, 2008.<br>"A dissertation in molecular biology and biochemistry and cell biology and biophysics." Advisor: Leonard L. Dobens. Typescript. Vita. Title from "catalog record" of the print edition Description based on contents viewed Sept. 12, 2008. Includes bibliographical references (leaves 120-147). Online version of the print edition.

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15

Ebrahimi, Maryam. "Examining the expression of potential cell-cycle regulators in the developing mouse inner ear." Thesis, McGill University, 2014. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=123245.

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Sensory epithelia of the mammalian inner ear are composed of hair cells and supporting cells. These cells originate from common precursors, which exit the cell cycle during late embryogenesis. Thereafter, hair cells and supporting cells maintain a non-proliferative state. As a result, hair cell loss in mammals is irreversible. If inner ear organs are to be regenerated, supporting cells must reenter the cell cycle to produce new hair cells and supporting cells. Little is known about genes that maintain the post-mitotic state of inner ear supporting cells. Previous studies revealed the role o

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16

Addison, M. E. "Investigating the roles of cell identity regulation and Eph/ephrin signalling in early hindbrain segmentation." Thesis, University College London (University of London), 2017. http://discovery.ucl.ac.uk/1559130/.

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During development of the vertebrate hindbrain, the neuroepithelium becomes subdivided into seven morphological units, known as rhombomeres. It is necessary that rhombomeres have sharp, well-defined boundaries, which are established from initially rough gene expression domains during early hindbrain segmentation. The mechanisms involved in early hindbrain segmentation that create sharp segment borders are not well understood. There is evidence to suggest that both regulation of cell identity and Eph/ephrin-mediated cell sorting are required for establishing sharp interfaces between rhombomeres

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17

Kabashima, Kenji. "The prostaglandin receptor EP4 suppresses colitis, mucosal damage and CD4 cell activation in the gut." Kyoto University, 2003. http://hdl.handle.net/2433/148729.

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18

Papworth, Karin. "Prognostic factors in renal cell carcinoma : evaluation of erythropoietin and its receptor, carbonic anhydrase IX, parathyroid hormone-related protein and osteopontin." Doctoral thesis, Umeå universitet, Onkologi, 2011. http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-40047.

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A prognostic factor is a marker or a feature that can be used to estimate the risk of recurrence of disease, metastatic spread and clinical outcome. Despite intensive search for more sophisticated markers in renal cell carcinoma (RCC), few have added prognostic information to earlier described factors like stage of disease, nuclear grade, tumour type, and in metastatic disease; performance status, anaemia, hypercalcaemia and increased erythrocyte sedimentation. In the dominating tumour type, clear cell renal RCC (cRCC), hypoxia is common, leading to an up-regulation of hypoxia inducible factor

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19

Kadner, Diana. "Mechanism of cell adhesion at the midbrain-hindbrain neural plate in the teleost Danio rerio." Doctoral thesis, Saechsische Landesbibliothek- Staats- und Universitaetsbibliothek Dresden, 2009. http://nbn-resolving.de/urn:nbn:de:bsz:14-qucosa-23142.

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The correct development of multicellular organisms is tightly regulated by intrinsic and extrinsic factors at specific time points. Disturbance on any level of these multiple processes may result in drastic phenotypes or eventually death of the organism. The midbrain-hindbrain boundary (also termed isthmic organizer) is a region of high interest as well in early as also in later development. The isthmic region carries organizer identity by the expression and subsequent release of FGF8. False patterning events of this region in early developmental stages would therefore display dramatic resul

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20

Taylor, Ruth Rebecca. "An in vitro study of hair cell regeneration in the inner ear of the newt, Notopthalmus viridescens." Thesis, University College London (University of London), 2003. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.406187.

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21

Presley, Tennille D. "Electron paramagnetic resonance (EPR) oximetry as a quantitative tool to measure cellular respiration in pathophysiological conditions." Columbus, Ohio : Ohio State University, 2007. http://rave.ohiolink.edu/etdc/view?acc%5Fnum=osu1187014988.

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22

Goodyear, Richard John. "Distribution and development of hair-cell surface and extracellular matrix components in the chick inner ear." Thesis, University of Sussex, 1994. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.359083.

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23

Quint, Elizabeth. "An investigation of hair-cell degeneration and regeneration in the guinea-pig inner ear in vivo and in vitro." Thesis, Keele University, 1996. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.337090.

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24

Davies, Alexander Lloyd. "Role of the frizzled signalling pathway in control of hair cell production and polarity in the developing inner ear." Thesis, University College London (University of London), 2002. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.399278.

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25

Pamarthi, Pavan Kumar [Verfasser]. "Role of prostanoid receptor EP1 in the progression of non-small cell lung cancer (NSCLC) / Pavan Kumar Pamarthi." Gießen : Universitätsbibliothek, 2013. http://d-nb.info/106518395X/34.

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26

Cortina, Duran Carme. "Role of EphB receptors in intestinal epithelial cell positioning and colorectal cancer progression." Doctoral thesis, Universitat Pompeu Fabra, 2009. http://hdl.handle.net/10803/35692.

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In the intestinal epithelium, Wnt signaling drives the expression of the genes encoding tyrosine kinase receptors EphB2 and EphB3 and represses the expression of their membrane-tethered ligands, ephrin-Bs. Eph-ephrin interactions result in cellular repulsion and are involved in boundary formation. The project of this thesis is to understand the mechanism by which EphB−ephrin-B signals restrict cell positioning of cell types (cell sorting) in the normal intestinal epithelium and suppress colorectal cancer (CRC) progression beyond the earliest stages. We have demonstrated that at the onse

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27

Lin, Chia-Hui. "The Effects of Growth Hormone in the Inner Ear of Zebrafish (Danio rerio) during Hair Cell Regeneration." TopSCHOLAR®, 2010. http://digitalcommons.wku.edu/theses/191.

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Although deafness is a universal problem, effective treatments have remained elusive. In order to develop potential treatments, an overall understanding of the cellular process of auditory hair cell regeneration, which occurs in fish but not mammals, must be established. A previous microarray analysis and qRT-PCR validation of noise-exposed zebrafish showed that growth hormone (GH) was significantly upregulated during the process of auditory hair cell regeneration. Thus, GH may play an important role during hair cell regeneration. However, cellular effects of exogenous GH in the zebrafish audi

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28

Serra, Pagès Mariona. "Selective EP2 agonism attenuates hdm-induced murine airway pathology and mast cell activity, and triggers intracellular inhibitory signaling in mast cells." Doctoral thesis, Universitat Autònoma de Barcelona, 2012. http://hdl.handle.net/10803/84009.

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L'asma al lèrgica és una malaltia respiratòria crònica amb una alta prevalença en els països desenvolupats. Els tractaments actuals no aturen el procés al lèrgic subjacent ni aconsegueixen el control dels símptomes de la malaltia. El tractament més eficaç és l'ús de corticoesteroids, que es basen en modificacions químiques de potents hormones endògenes antiinflamatòries. L'estudi de vies antiinflamatòries endògenes és una estratègia experimental eficaç per descobrir noves dianes terapèutiques potencials contra l'asma. Una d'aquestes vies endògenes és la de la ciclooxigenasa (COX). Prost

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29

Lewis, Stephanie Rochelle. "Experimental infection with Sarcocystis neurona alters the immune response: the effect on CD4+, CD8+, B-cell, monocyte and granulocyte populations in horses." Thesis, Virginia Tech, 2009. http://hdl.handle.net/10919/33919.

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Previous studies have demonstrated differences in CD4+, CD8+ and B-cell populations between EPM affected and normal horses. The overall goal of our project was to further define the immune deficiencies associated with S. neurona infection. We hypothesized that PMA/I stimulated suppression in EPM horses is due to decreased proliferation of monocytes, CD4+ and CD8+ cells. Our objectives were 1) to determine whether S. neurona infection causes an increase in apoptosis of a particular immune subset, and 2) to determine whether S. neurona causes a decrease in the number of cellular divisions (proli

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30

Rubbini, Davide 1985. "Retinoic acid signaling mediates hair cell regeneration by repressing p27kip and sox2 in supporting cells." Doctoral thesis, Universitat Pompeu Fabra, 2016. http://hdl.handle.net/10803/380543.

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Hair cell damage, caused by various insults, results in hearing loss in humans, one of the major health problems nowadays. In mammals damaged hair cells cannot regenerate, whereas lower vertebrates have retained the ability to replace them by inducing cell proliferation of supporting cells and/or their transdifferentiation. Retinoic Acid (RA) has been implicated in several organs regeneration but its role in hair cell regeneration is unknown. A combination of gene expression profiling, functional assays and cell-lineage tracing experiments allows us to highlight the importance of the RA pathwa

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31

Dieckmann, Mark Eric. "A survey of elementary plasma instabilities and ECH wave noise properties relevant to plasma sounding by means of particle in cell simulations." Thesis, University of Warwick, 1999. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.327557.

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32

Hammad, Mira. "Reconstruction of auricular cartilage using natural-derived scaffolds with an in vivo application in rabbit model Effects of hypoxia on chondrogenic differentiation of progenitor cells from different origins Cell sheets as tools for ear cartilage reconstruction in vivo Cartilage tissue engineering using apple cellulosic scaffolds Cell-secreted matrices as cell supports: Novel approaches for cell culture applications." Thesis, Normandie, 2021. http://www.theses.fr/2021NORMC404.

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La reconstruction des défauts du cartilage auriculaire nécessite une restauration appropriée par des sources cellulaires adéquates ainsi que la fourniture de supports appropriés pour les tissus. Ce travail visait à étudier différents échafaudages et biomatériaux pour l'ingénierie in vitro du cartilage auriculaire ainsi que la réparation in vivo du cartilage auriculaire chez des modèles de lapin. Nous avons d'abord montré que les périchondrocytes auriculaires sont les meilleurs candidats pour la régénération du cartilage auriculaire et que l'hypoxie n'est pas nécessaire à leur différenciation c

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33

Ferguson, Shawn. "Non-steriodal anti-inflammatory drug-mediated regulation of COX-2 and EP3 receptor expression in the M-1 murine cortical collecting duct cell line." Thesis, University of Ottawa (Canada), 1999. http://hdl.handle.net/10393/8909.

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The cortical collecting duct (CCD) is a major site of intrarenal prostaglandin E2 (PGE2) synthesis. By indirect immunofluorescence using isoform specific antibodies, we have localized COX-1 and -2 immunoreactivity to all cell types of the murine M-1 CCD cell line. By, immunohistochemistry, both COX-1 and COX-2 were localized to the intercalated cells of the collecting duct on paraffin embedded mouse kidney sections. When COX enzyme activity was measured in the M-1 cells, both indomethacin (COX-1 and -2 inhibitor) and the specific COX-2 inhibitor NS-398 effectively blocked PGE2 synthesis. These

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34

Shani, Saeideh. "The implication of cell-derived microvesicles in retinal pigment epithelium degeneration." Thèse, 2018. http://hdl.handle.net/1866/22150.

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35

Ashby, Edwina Kingsley. "EphA4 and ephrin-A interactions in avian neural crest cell segmentation." Thesis, 2005. http://hdl.handle.net/2440/61969.

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This thesis has involved the analysis of Eph/ephrin-A gene expression with respect to NC (neural crest) cell segmentation, identified EphA4 as a putative regulator of cell-cell communication during NC cell migration and more specifically, established that this protein plays a critical negative regulatory role in EMT.<br>Thesis (Ph.D.) -- University of Adelaide, School of Molecular and Biological Sciences, 2005

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36

Newton, Sandra Claire. "Effects of a classroom-based direct instruction reading intervention for young children with sickle cell disease." 2004. http://link.library.utoronto.ca/eir/EIRdetail.cfm?Resources__ID=81089&T=F.

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37

Watson, H., A. J. Cockbain, Jade A. Spencer, et al. "Measurement of red blood cell eicosapentaenoic acid (EPA) levels in a randomised trial of EPA in patients with colorectal cancer liver metastases." 2016. http://hdl.handle.net/10454/10200.

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Yes<br>We investigated red blood cell (RBC) PUFA profiles, and the predictive value of RBC EPA content for tumour EPA exposure and clinical outcomes, in the EMT study, a randomised trial of EPA in patients awaiting colorectal cancer (CRC) liver metastasis surgery (A.J. Cockbain et al., 2014). There was a significant increase in RBC EPA in the EPA group (n=43; median intervention 30 days; mean absolute 1.26 [±0.14]% increase; P<0.001), but not in the placebo arm (n=45). EPA incorporation varied widely in EPA users and was not explained by treatment duration or compliance. There was little evide

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38

Krupke, Oliver A. "Cell signaling guides morphogenesis: roles for Eph-Ephrin signaling in sea urchin morphogenesis." Thesis, 2015. http://hdl.handle.net/1828/6443.

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The role that signaling molecules play during morphogenesis and their interactions is a field of intense study and the sea urchin represents a facile system to study these aspects of development in the early embryo. In many instances, the S. purpuratus genome contains relatively simple receptor-ligand signaling systems compared to vertebrate counterparts and this provides interesting opportunities to study their diversity of function during the morphogenetic events that shape the embryo. The Eph-Ephrin signaling components are an excellent example of this and they are represented by dozens of

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39

Martinez, Calixto Luis Edmundo. "In situ expression of cytokeratins and Ber-EP4 antigen in ameloblastomas and basal cell carcinomas." 2006. http://proquest.umi.com/pqdweb?did=1075713341&sid=9&Fmt=2&clientId=39334&RQT=309&VName=PQD.

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Thesis (M.S.)--State University of New York at Buffalo, 2006.<br>Title from PDF title page (viewed on July. 19, 2006) Available through UMI ProQuest Digital Dissertations. Thesis adviser: Aguirre, Alfredo. Includes bibliographical references.

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40

Pai, Chien-Hua, and 白倩華. "Erythropoietin (EPO) Attenuated Nitric Oxide Cytotoxicity in a Human Neuronal Progenitor NT2 Cell Line." Thesis, 2000. http://ndltd.ncl.edu.tw/handle/73861155463822622457.

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碩士<br>國立陽明大學<br>醫學生物技術研究所<br>88<br>Erythropoietin (EPO), a 34-kD glycoprotein produced in the mammalian kidney and liver, was originally thought to act only on erythroid progenitor cells by stimulating their survival, proliferation, and differentiation. There is now evidence that EPO and EPO receptor mRNA are present in certain nonhematopoietic tissues such as the developing human CNS, and a human committed neuronal precursor cell line (NT2) derived from teratocarcinoma. However, the physiological role of EPO at these sites remains to be elucidated. In this study, we assessed the protective ef

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41

Koo, Diana Hung-Hung. "The role of discoidin domain receptor 1 in maintaining E-cadherin-mediated cell-cell contacts in the mammary gland." 2007. http://link.library.utoronto.ca/eir/EIRdetail.cfm?Resources__ID=452872&T=F.

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42

Elghouche, Alhasan Najib. "Modulation of the Notch Signaling Pathway in 3D Stem-Cell Derived Culture of Inner Ear Organoids." 2016. http://hdl.handle.net/1805/10907.

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Indiana University-Purdue University Indianapolis (IUPUI)<br>Hearing loss and vestibular dysfunction are inner ear disease states that arise from an array of diverse etiologies that interfere with mechanosensory hair cell function, including: congenital syndromes, noise-induced trauma, ototoxic drugs, and aging. The investigation of normal inner ear development and the pathological aberrations that cause inner ear disease has been previously advanced through formation of an easily generated, scalable, accurate in vitro model system that readily facilitates experimental applications. This

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43

Kuo, Kuang-Tai, and 郭光泰. "The Roles of PGE2 Receptor EP2 and Epithelial-Mesenchymal Transition in Tumor Invasion in Esophageal Squamous Cell Carcinoma." Thesis, 2011. http://ndltd.ncl.edu.tw/handle/43206953913702866705.

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博士<br>國立陽明大學<br>臨床醫學研究所<br>100<br>Esophageal cancer is ranking the sixth most lethal cause for male cancer patients in Taiwan and is responsible for nearly 1,500 deaths per year. Currently, its 5-year survival is still less than 20%. Recently, it has been well known that cyclooxygenase-2 (COX-2) plays an important role in tumor progression of several cancers and PGE2 is linked to carcinogenesis more closely than other prostaglandins. PGE2 elaborates its biological activities via PGE2 receptors, namely EPs, which are composed of four isoforms (EP1 to EP4). Regarding esophageal cancer, previous

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44

Kauzman, Adel. "Cyclin D1 alterations in giant cell tumor of bone and central giant cell granuloma of the jaw." 2004. http://link.library.utoronto.ca/eir/EIRdetail.cfm?Resources__ID=80965&T=F.

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45

Li, Elaine Y. H. "Immunological reaction in cell transplantation into the infarcted myocardium." 2004. http://link.library.utoronto.ca/eir/EIRdetail.cfm?Resources__ID=95206&T=F.

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46

Austin, James W. "Molecular mechanisms of Fas mediated cell death in oligodendrocytes." 2006. http://link.library.utoronto.ca/eir/EIRdetail.cfm?Resources__ID=450581&T=F.

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47

Yau, Daphne. "Insulin resistance precipitates beta-cell dysfunction and beta-cell expansion in a non-obese model of type 2 diabetes." 2005. http://link.library.utoronto.ca/eir/EIRdetail.cfm?Resources__ID=370474&T=F.

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48

Ashtiani, Kaihan Abidi. "A two-dimensional particle-in-cell (PIC) model of an axisymmetric electron-cyclotron-resonance (ECR) plasma-processing system." 1995. http://catalog.hathitrust.org/api/volumes/oclc/32864984.html.

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49

Lu, Carole Chih-Chen. "Cranial Neural Crest Cell Migration in the Avian Embryo and the Roles of Eph-A4 and Ephrin-A5." Thesis, 2007. https://thesis.library.caltech.edu/4073/1/carole_lu.pdf.

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<p>The neural crest is a transient population of cells that migrate away from the dorsal neural tube in the vertebrate embryo. As the developing hindbrain constricts into rhombomeres, cranial neural crest cells migrate in three discrete streams adjacent to even-numbered rhombomeres, rhombomere 2 (r2), r4, and r6.</p> <p>To test the role of intrinsic versus extrinsic cues in influencing an individual cell’s trajectory, we implanted physical barriers in the chick mesoderm, distal to emerging neural crest cells (NCCs). We analyzed spatio-temporal dynamics as NCCs encountered and responded to t

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Saibil, Samuel David. "Protein kinase B signaling in T cell survival and tolerance." 2009. http://link.library.utoronto.ca/eir/EIRdetail.cfm?Resources__ID=968417&T=F.

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