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Artículos de revistas sobre el tema "In vitro swallowing"

Autor: Grafiati

Publicado: 24 de agosto de 2024

Última modificación: 31 de julio de 2025

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1

Patel, Simmi, William J. McAuley, Michael T. Cook, Yi Sun, Shaheen Hamdy, and Fang Liu. "The Swallowing Characteristics of Thickeners, Jellies and Yoghurt Observed Using an In Vitro Model." Dysphagia 35, no. 4 (2019): 685–95. http://dx.doi.org/10.1007/s00455-019-10074-1.

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Abstract Drinks and foods may be thickened to improve swallowing safety for dysphagia patients, but the resultant consistencies are not always palatable. Characterising alternative appetising foods is an important task. The study aims to characterise the in vitro swallowing behaviour of specifically formulated thickened dysphagia fluids containing xanthan gum and/or starch with standard jellies and yoghurt using a validated mechanical model, the “Cambridge Throat”. Observing from the side, the model throat can follow an experimental oral transit time (in vitro-OTT) and a bolus length (BL) at t

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2

Chakder, S., G. J. Rosenthal, and S. Rattan. "In vivo and in vitro influence of human recombinant hemoglobin on esophageal function." American Journal of Physiology-Gastrointestinal and Liver Physiology 268, no. 3 (1995): G443—G450. http://dx.doi.org/10.1152/ajpgi.1995.268.3.g443.

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The purpose of the present investigation was to examine the influence of a nitric oxide scavenger, hemoglobin (Hb), on esophageal function. Intraluminal pressures of anesthetized opossums were recorded from lower esophageal sphincter (LES) and 1, 5, and 9 cm above the LES. The influence of a representative Hb-based oxygen carrier was examined on swallowing-induced esophageal peristalsis and LES relaxation. In in vitro studies, LES relaxation and esophageal peristaltic contractions were induced by the activation of nonadrenergic noncholinergic (NANC) neurons by electrical field stimulation (EFS

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3

Malouh, Marwa A., Julie A. Y. Cichero, Yu Sun, Esther T. L. Lau, Lisa M. Nissen, and Kathryn J. Steadman. "Medication Lubricants for Oral Delivery of Drugs: Oral Processing Reduces Thickness, Changes Characteristics, and Improves Dissolution Profile." Pharmaceutics 16, no. 3 (2024): 417. http://dx.doi.org/10.3390/pharmaceutics16030417.

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Swallowing oral solid dosage forms is challenging for those who have medication swallowing difficulties, including patients with dysphagia. One option is to mix the drug (whole or crushed) with a thick vehicle (medication lubricant). Previous in vitro studies consistently suggest that thick vehicles could impact the dissolution of solid dosage forms, potentially influencing their therapeutic effectiveness, but do not account for changes that happen during oral processing and swallowing. This study aims to investigate the potential impact of medication lubricants on drug release and examine the

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Marconati, Marco, and Marco Ramaioli. "The role of extensional rheology in the oral phase of swallowing: an in vitro study." Food & Function 11, no. 5 (2020): 4363–75. http://dx.doi.org/10.1039/c9fo02327e.

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In vitro swallowing experiments suggest that thin, viscoelastic liquids with strong apparent extensional viscosity lead to fast transit, lower oral residues and a compact bolus leaving the oral cavity.

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Fujiso, Yo, Nicolas Perrin, Julian van der Giessen, Nihal Engin Vrana, Fabrice Neveu, and Virginie Woisard. "Swall-E: A robotic in-vitro simulation of human swallowing." PLOS ONE 13, no. 12 (2018): e0208193. http://dx.doi.org/10.1371/journal.pone.0208193.

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Eremin, V. A., and E. V. Blynskaya. "Modern approaches to assessing the quality of orally disintegrating tablets." Farmacevticheskoe delo i tehnologija lekarstv (Pharmacy and Pharmaceutical Technology), no. 6 (December 19, 2023): 8–17. http://dx.doi.org/10.33920/med-13-2306-01.

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Orally disintegrating tablets (ODTs) are the preferred and accepted solid dosage forms by patients. These tablets disintegrate in the oral cavity within a short period, providing an advantage for individuals who have difficulty swallowing. Quality control of ODTs can be achieved through measures such as friability, porosity, hardness, wetting time, water absorption capacity, in vitro disintegration test, and dissolution test. This article summarizes the advantages and in vitro quality control tests of orally disintegrating tablets.

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Tafere, Chernet, Zewdu Yilma, Solomon Abrha, and Adane Yehualaw. "Formulation, in vitro characterization and optimization of taste-masked orally disintegrating co-trimoxazole tablet by direct compression." PLOS ONE 16, no. 3 (2021): e0246648. http://dx.doi.org/10.1371/journal.pone.0246648.

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Introduction Orally disintegrating tablet (ODT) is a dosage form that overcomes the problem of swallowing which is prevalent in about 35% of the general population. Co-trimoxazole (CTX) is given for patients with HIV for the prophylaxis of opportunistic infection (OI), commonly for pneumocystis carinii pneumonia. It was reported that CTX was associated with a 25–46% reduction in mortality among individuals infected with HIV in sub-Saharan Africa. Esophageal candidiasis which usually comes along with HIV/AIDS is one of AIDS defining illness affecting up to 1 in 5 of people with AIDS. This oppor

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Pawar, Harshal Ashok, and Pooja Rasiklal Joshi. "Development and Evaluation of Taste Masked Granular Formulation of Satranidazole by Melt Granulation Technique." Journal of Pharmaceutics 2014 (February 12, 2014): 1–7. http://dx.doi.org/10.1155/2014/789676.

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Drugs from nitroimidazole category are generally bitter in taste. Oral formulation with bitter taste is not palatable. Geriatrics and pediatrics patients usually suffer from swallowing difficulties. Many other patients in some disease conditions avoid swallowing tablets. Satranidazole is a new nitro-imidazole derivative with bitter taste and is available in market as film coated tablet. The purpose of this research was to mask the bitter taste of Satranidazole by coating complexation with low melting point wax and Eudragit EPO. Different types of wax (glyceryl monostearate, stearic acid and ce

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Seifelnasr, Amr, Xiuhua Si, Peng Ding, and Jinxiang Xi. "Liquid Dynamics in the Upper Respiratory–Digestive System with Contracting Pharynx Motions and Varying Epiglottis Angles." Liquids 4, no. 2 (2024): 415–31. http://dx.doi.org/10.3390/liquids4020022.

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Swallowing disorders, or dysphagia, can lead to bolus aspiration in the airway, causing serious adverse health effects. Current clinical interventions for dysphagia are mainly empirical and often based on symptoms rather than etiology, of which a thorough understanding is still lacking. However, it is challenging to study the swallowing process that involves sequential structural motions and is inaccessible to standard visualization instruments. This study proposed an in vitro method to visualize swallowing hydrodynamics and identify the fundamental mechanisms underlying overflow aspirations.

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Kaur, Kiranpreet* and Garg Rajeev. "FAST DISSOLVING TABLET – AN INNOVATIVE APPROACH." INDO AMERICAN JOURNAL OF PHARMACEUTICAL SCIENCES 05, no. 10 (2018): 10603–11. https://doi.org/10.5281/zenodo.1469989.

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<em>Fast dissolving tablets are the most supportive and widely accepted dosage forms, commonly for pediatric patients. </em><em>Some solid dosage forms like capsules and tablets have issue like worry of swallowing called dysphagia, resulting in matter of patient non-compliance and making the therapy inefficient. FDT disintegrate or dissolve quickly in the saliva in lack of water in within a few seconds (less than 60 seconds) and are real fast dissolving tablets. FDTs are designed to disintegrate speedily, absorb faster so,in vitro drug release time improve and this property of drugs enhanced b

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Rekling, Jens C., and Jack L. Feldman. "Calcium-Dependent Plateau Potentials in Rostral Ambiguus Neurons in the Newborn Mouse Brain Stem In Vitro." Journal of Neurophysiology 78, no. 5 (1997): 2483–92. http://dx.doi.org/10.1152/jn.1997.78.5.2483.

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Rekling, Jens C. and Jack L. Feldman. Calcium-dependent plateau potentials in rostral ambiguus neurons in the newborn mouse brain stem in vitro. J. Neurophysiol. 78: 2483–2492, 1997. The nucleus ambiguus contains vagal and glossopharyngeal motoneurons and preganglionic neurons involved in respiration, swallowing, vocalization, and control of heart beat. Here we show that the rostral compact formation's ambiguus neurons, which control the esophageal phase of swallowing, display calcium-dependent plateau potentials in response to tetanic orthodromic stimulation or current injection. Whole cell r

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Kogo, Mikihiko, Tadashi Yamanishi, Hidehiko Koizumi, and Tokuzo Matsuya. "Swallowing-like activity elicited in vitro in neonatal rat organ attached brainstem block preparation." Brain Research 955, no. 1-2 (2002): 24–33. http://dx.doi.org/10.1016/s0006-8993(02)03339-5.

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Ershad, Abdul Latif, Ali Rajabi-Siahboomi, Shahrzad Missaghi, Daniel Kirby, and Afzal Rahman Mohammed. "Multi-Analytical Framework to Assess the In Vitro Swallowability of Solid Oral Dosage Forms Targeting Patient Acceptability and Adherence." Pharmaceutics 13, no. 3 (2021): 411. http://dx.doi.org/10.3390/pharmaceutics13030411.

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A lack of effective intervention in addressing patient non-adherence and the acceptability of solid oral dosage forms combined with the clinical consequences of swallowing problems in an ageing world population highlight the need for developing methods to study the swallowability of tablets. Due to the absence of suitable techniques, this study developed various in vitro analytical tools to assess physical properties governing the swallowing process of tablets by mimicking static and dynamic stages of time-independent oral transitioning events. Non-anatomical models with oral mucosa-mimicking

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Drushel, R. F., D. M. Neustadter, L. L. Shallenberger, P. E. Crago, and H. J. Chiel. "The kinematics of swallowing in the buccal mass of Aplysia californica." Journal of Experimental Biology 200, no. 4 (1997): 735–52. http://dx.doi.org/10.1242/jeb.200.4.735.

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Changes in the positions, shapes and movements of the feeding apparatus (buccal mass) of the marine mollusc Aplysia californica were studied in intact, transilluminated juveniles. The buccal mass assumes characteristic shapes as its internal structure, the radula/odontophore, moves anteriorly (protracts) or posteriorly (retracts). These shapes are especially distinctive when the radula/odontophore has protracted forwards fully, is close to its resting or neutral position, or has retracted backwards fully. We refer to the shapes that occur at full protraction, transition and full retraction as

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Singh, Kehar, Gaikwad Dushyant Dadabhau, and Satbir Singh. "Formulation Design and Development of Fast Disintegrating Tablets of Losartan Potassium By Using Locast Bean Gum As Superdisintigrants." International Journal of Membrane Science and Technology 10, no. 5 (2023): 1084–96. http://dx.doi.org/10.15379/ijmst.v10i5.3700.

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For patients who have trouble swallowing tablets, capsules, etc., fast dissolving drug delivery devices provide an option. Water is not necessary for the swallowing of fast dissolving pills because they dissolve instantly in the mouth. Using locust bean gum as a natural superdisintegrant, the present work set out to produce fast-dissolving tablets of losartan potassium. Perform pre formulation studies like partition coefficient, solubility and identification of drug. The influence of precompressional parameters like interaction studies and compatibility. Other tablet properties were examined,

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Prabhat, Dessai*and Kajal Rao. "FORMULATION DEVELOPMENT AND EVALUATION OF MEDICATED JELLY WITH CUMINUM CYMINUM EXTRACT AND ITS COMPARATIVE STUDY USING DIFFERENT JELLING AGENTS." INDO AMERICAN JOURNAL OF PHARMACEUTICAL SCIENCES 05, no. 04 (2018): 2117–23. https://doi.org/10.5281/zenodo.1214548.

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Convenience of administration and patient compliance are gaining significant importance in the design of dosage forms. Present study was aimed to formulate and evaluate medicated Jelly of Cuminum cyminum using polymers like sodium alginate and tragacanth. Difficulty in swallowing is common among all age groups, especially in elderly and pediatrics. Physical characteristics, pH, in vitro % drug release kinetics, content uniformity, spreadability, IR spectral analysis, and stability studies were conducted. IR spectroscopic studies indicated that there were no drugexcipient interactions with trag

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S. Pallavi, A. Madhusudhan Reddy, and B. Thejovathi. "Formulation Development And In Vitro Evaluation Of Oral Dissolving Films Of Palonosetron." International Journal of Pharmaceuticals and Health Care Research 12, no. 4 (2024): 377–88. https://doi.org/10.61096/ijphr.v12.iss4.2024.377-388.

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Palonosetron is an5-HT3 antagonist used in the prevention and treatment of chemotherapy-induced nausea and vomiting (CINV). It is used for the control of delayed CINV—nausea and vomiting and there are tentative data to suggest that it may be more effective than granisetron. Present work aimed at preparing quick onset of action which is beneficial in hypertension, aiding in the enhancement of bioavailabity and is very convenient for administration without the problem of swallowing and using water. The film were prepared by using polymers such as Polyvinyl alcohol, Maltodextrin and Propylene gly

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Sherman, Ethan G., Patrick J. Antonelli, and Roger Tran-Son-Tay. "In vitro testing of tympanostomy tube occlusion." Otolaryngology–Head and Neck Surgery 141, no. 5 (2009): 598–602. http://dx.doi.org/10.1016/j.otohns.2009.08.019.

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Objective: Tympanostomy tubes (TTs) are commonly rendered nonfunctional by mucus plug formation. The purpose of this study was to determine whether an in vitro model could be developed to assess TT plug formation with results consistent with human trials. Study Design: An ear chamber was designed to mimic middle ear air and mucus flow conditions in post-TT otorrhea. TT occlusion was tested and correlated to published in vivo results. Methods: TTs that had previously been studied in vivo (Goode “T” and Reuter Bobbin collar buttons) were placed in the model chamber. Pooled, homogenized human mid

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Oral, disintegrating film Hydroxypropyl methylcellulose Solvent casting Brivaracetam. "Formulation And Evaluation of Oral Disintegrating Film Containing Brivaracetam." International Journal of Pharmaceutical Sciences 2, no. 11 (2024): 556–65. https://doi.org/10.5281/zenodo.14106902.

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Oral disintegrating films (ODFs) are innovative drug delivery systems designed to dissolve rapidly in the oral cavity without the need for water. These films are particularly beneficial for patients who have difficulty swallowing traditional dosage forms, such as the elderly and paediatric populations. This study aims to develop ODF containing Brivaracetam were formulated using a different grade of HPMC E15 and HPMC E50 and plasticizers like polyethylene glycol and propylene glycol using solvent casting method. The formulated films were evaluated for thickness, folding endurance, weight variat

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Mahmood, Sura Zuhair, Hiba Sabah Sabry, Nora Zawar Yousif, and Zeina D. Salman. "OPTIMIZATION AND EVALUATION OF CHLORPHENIRAMINE MALEATE ORAL STRIP FOR PEDIATRIC USE." Asian Journal of Pharmaceutical and Clinical Research 11, no. 12 (2018): 548. http://dx.doi.org/10.22159/ajpcr.2018.v11i12.28985.

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Objective: The goal of performing this study is to prepare an oral strip, especially designed for pediatric use that provides fast onset of action with ease of swallowing particularly for young individuals who suffer from difficulty of swallowing, in addition provides maximum therapeutic effectiveness by reducing the first pass effect.Materials and Methods: The oral strip was prepared by solvent casting technique through using different sole polymers (hydroxypropyl methylcellulose [HPMC] 15cp, HPMC 50cp, polyvinyl alcohol, and sodium carboxymethyl cellulose). Maltodextrin (MD) was added as the

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Sharma, Deepak, Mankaran Singh, Dinesh Kumar, and Gurmeet Singh. "Formulation Development and Evaluation of Fast Disintegrating Tablet of Cetirizine Hydrochloride: A Novel Drug Delivery for Pediatrics and Geriatrics." Journal of Pharmaceutics 2014 (February 18, 2014): 1–8. http://dx.doi.org/10.1155/2014/808167.

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Recent developments in fast disintegrating tablets have brought convenience in dosing to pediatric and elderly patients who have trouble in swallowing tablets. The objective of the present study was to prepare the fast disintegrating tablet of Cetirizine Hydrochloride for allergic and respiratory disorders. As precision of dosing and patient's compliance become important prerequisite for a long-term treatment, there is a need to develop a formulation for this drug which overcomes problems such as difficulty in swallowing, inconvenience in administration while travelling, and patient’s acceptab

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Sharma, Deepak. "Formulation Development and Evaluation of Fast Disintegrating Tablets of Salbutamol Sulphate for Respiratory Disorders." ISRN Pharmaceutics 2013 (July 15, 2013): 1–8. http://dx.doi.org/10.1155/2013/674507.

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Recent developments in fast disintegrating tablets have brought convenience in dosing to pediatric and elderly patients who have trouble in swallowing tablets. The objective of the present study was to prepare the fast disintegrating tablet of salbutamol sulphate for respiratory disorders for pediatrics. As precision of dosing and patient's compliance become important prerequisites for a long-term treatment, there is a need to develop a formulation for this drug which overcomes problems such as difficulty in swallowing, inconvenience in administration while travelling, and patient’s acceptabil

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Satpute, Mangesh Machhindranath, and Nagesh Shivaji Tour. "Formulation and in vitro evaluation of fast dissolving tablets of metoprolol tartrate." Brazilian Journal of Pharmaceutical Sciences 49, no. 4 (2013): 783–92. http://dx.doi.org/10.1590/s1984-82502013000400018.

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The demand for fast dissolving tablets has been growing during the last decade, especially for elderly and children who have swallowing difficulties. In the present work, fast dissolving tablets of metoprolol tartrate, were prepared using sodium starch glycolate, sodium croscarmellose and crospovidone as superdisintegrants, by the direct compression method. The tablets prepared were evaluated for various parameters including weight variation, hardness, friability, in vitro dispersion time, drug-polymer interaction, drug content water absorption ratio, wetting time, in vitro drug release, FTIR

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Alpos, Marbie, Sze Ying Leong, Veronica Liesaputra, Candace E. Martin, and Indrawati Oey. "Understanding In Vivo Mastication Behaviour and In Vitro Starch and Protein Digestibility of Pulsed Electric Field-Treated Black Beans after Cooking." Foods 10, no. 11 (2021): 2540. http://dx.doi.org/10.3390/foods10112540.

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The aim of this study was to understand (i) the in vivo mastication behaviour of cooked black beans (chewing duration, texture perception, oral bolus particle size, microstructure, and salivary α-amylase) and (ii) the in vitro digestibility of starch and protein of in vivo-generated black bean oral bolus under simulated gastrointestinal condition. The beans were pre-treated using pulsed electric field (PEF) with and without calcium chloride (CaCl2) addition prior to cooking. The surface response model based on least square was used to optimise PEF processing condition in order to achieve the s

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Hebert, Mello, Richard Moore, Eric Jen, and Scott Siegert. "Complete in vitro Dissolution of Valbenazine as Either Whole Capsules or Crushed Capsule Contents." CNS Spectrums 28, no. 2 (2023): 227. http://dx.doi.org/10.1017/s1092852923001499.

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AbstractIntroductionTardive dyskinesia (TD) is a persistent and potentially disabling movement disorder associated with exposure to antipsychotics and other dopamine receptor blocking agents. Three valbenazine capsule strengths (40 mg, 60 mg, 80 mg) are approved for the once-daily treatment of TD. However, some patients with TD, especially in elderly populations, have trouble swallowing due to orolingual movements. This study was conducted to evaluate two different dissolution methods for valbenazine: whole intact capsules versus crushed capsule contents.MethodsSamples were prepared using two

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T.AYYAPPAN, A.V.ARCHANA, B.MANOJ, and .T.AYYAPPAN Dr. "Studies on Formulation and in-Vitro Evaluation of Mouth Dissolving Tablets Containing Telmisartan by using Box-Benkhen Design." International Journal of Innovative Science and Research Technology 8, no. 2 (2023): 206–12. https://doi.org/10.5281/zenodo.7648002.

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New era is an era of novel drug delivery systems. Pediatric, Geriatric and bed ridden patients have difficulties in swallowing tablets. The purpose of the present study was to develop and characterize mouth dissolving tablets of Telmisartan by using direct compression technique. Formulations were designed by factorial design technique. Sodium Saccharine, Cross povidone and Banana powder were used as a superdisintegrants while microcrystalline cellulose was used as diluents. The powder blends were prepared and evaluated for the properties such as angle of repose, loose bulk density, tapped bulk

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Pradyumna Chaudhari, Shanti Saran Koiri, Ashish Lamsal, and Roshan Kumar Mehta. "Formulation and Evaluation of Fast Disintegrating Tablet of Salbutamol Sulphate." Journal of Universal College of Medical Sciences 12, no. 02 (2024): 29–33. http://dx.doi.org/10.3126/jucms.v12i02.69619.

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INTRODUCTION When put on the tongue, fast dissolving tablets immediately dissolve, often in a matter of seconds. They do not need any additional water to make them easier to swallow. Salbutamol sulphate fast disintegrating tablets have a higher bioavailability and dissolving rate. MATERIAL AND METHODS This experimental study was conducted in the Pharmaceutic laboratory of Department of Pharmacy at Universal College of Medical Sciences, Bhairahawa, Nepal from February 2022 to July 2022. A tablet was created utilizing the direct compression method employing mannitol as a diluent and various quan

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Ashwini, Warnkar* Dr. M. A. Channawar Dr. A. V. Chandewar Anjali Bhansali Anisha Kohale Gaurav Magar. "Design, Development and In-Vitro Characterization of Rapidly Disintegrating Oral Solid Dosage Form." International Journal of Pharmaceutical Sciences 3, no. 5 (2025): 4731–49. https://doi.org/10.5281/zenodo.15545054.

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The objective of the present study was to design, develop, and evaluate rapidly disintegrating oral films (RDOFs) of Ketorolac Tromethamine for effective pain management, especially in patients with swallowing difficulties. Oral films offer a convenient and patient-friendly alternative to traditional solid dosage forms due to their rapid disintegration and absorption through the oral mucosa. Ketorolac Tromethamine, a potent non-steroidal anti-inflammatory drug (NSAID), was selected as the active pharmaceutical ingredient due to its rapid onset of action. Various film-forming polymers such as H

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Almajidi, Yasser Q., Zainab H. Mahdi, and Nidhal K. Maraie. "PREPARATION AND IN VITRO EVALUATION OF MONTELUKAST SODIUM ORAL NANOEMULSION." International Journal of Applied Pharmaceutics 10, no. 5 (2018): 49. http://dx.doi.org/10.22159/ijap.2018v10i5.28367.

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Objective: Oral nanoemulsion (NE) represent one of the newest technology to enhance intestinal drug permeability, bioavailability and facilitate swallowing of the oral dosage form.Methods: In this study, montelukast sodium (MS) nanoemulsions (NEs) were formulated by ultra-sonication using different surfactants (tween 20, tween 60 and tween 80) in different surfactant: co-surfactant (ethanol) ratios (Smix). The prepared NEs were evaluated for different parameters including droplet size (DS) using zetasizer as a function of ultra-sonication time, dispersibility, phase separation, conductivity, p

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Pashikanti, Shailaja, and Jyothsna B. "FORMULATION AND EVALUATION OF FLOATING IN SITU GEL OF CIPROFLOXACIN." International Journal of Applied Pharmaceutics 11, no. 1 (2019): 198. http://dx.doi.org/10.22159/ijap.2019v11i1.28603.

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Objective: The objective of the study was to develop floating in situ gel formulations of Ciprofloxacin that has a narrow absorption window and mainly absorbed in the proximal areas of GIT. These formulations increases the targeted action on bacteria for a longer time that can be used in the treatment of Helicobacter pylori (H. pylori) infections and urinary tract infections.Methods: In situ gel formulations were prepared by varying concentrations of sodium alginate as in situ gel forming bio-degradable polymer and calcium carbonate as a cross-linking agent. The formulations were evaluated for

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McManus, Jeffrey M., Hui Lu, Miranda J. Cullins, and Hillel J. Chiel. "Differential activation of an identified motor neuron and neuromodulation provide Aplysia's retractor muscle an additional function." Journal of Neurophysiology 112, no. 4 (2014): 778–91. http://dx.doi.org/10.1152/jn.00148.2014.

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To survive, animals must use the same peripheral structures to perform a variety of tasks. How does a nervous system employ one muscle to perform multiple functions? We addressed this question through work on the I3 jaw muscle of the marine mollusk Aplysia californica's feeding system. This muscle mediates retraction of Aplysia's food grasper in multiple feeding responses and is innervated by a pool of identified neurons that activate different muscle regions. One I3 motor neuron, B38, is active in the protraction phase, rather than the retraction phase, suggesting the muscle has an additional

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Pecora, Tiziana Maria Grazia, Barbara Ragazzo, Walter Bertin, et al. "Rheological Behavior of a New Mucoadhesive Oral Formulation Based on Sodium Chondroitin Sulfate, Xyloglucan and Glycerol." Journal of Functional Biomaterials 12, no. 2 (2021): 28. http://dx.doi.org/10.3390/jfb12020028.

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Background: The study aimed at assessing the mucoadhesive properties and the barrier effect of a formulation, labelled as AL2106, containing sodium chondroitin sulfate (ChS), xyloglucan from tamarind seed extract, and glycerol, by evaluating the capacity to adhere to a layer of mucin, the rheological synergism and the barrier effect in comparison to the marketed Esoxx One medical device. AL2106 is a medical device distributed by Alfasigma SpA, Italy with REF FTP57 (Manufacturer: Labomar SpA); it is analogous to Esoxx One medical device: the two products are drinkable solutions that, after swal

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Pramod, Prakash Ronge* Dr. A.D. Shinde. "A REVIEW ON –FORMULATION AND IN-VITRO EVALUATION OF ORODISPERSIBLE TABLETS." INDO AMERICAN JOURNAL OF PHARMACEUTICAL SCIENCES o6, no. 05 (2019): 10991–1000. https://doi.org/10.5281/zenodo.3234069.

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<em>Recent advances in novel drug delivery (NDDS) aims to enhance the safety and efficacy of drug molecule by formulating a convenient dosage form for ease of administration and to achieve better patient compliance.</em><em> Orodispersible tablet is advanced and convenient drug delivery system, now days acquiring the most widely accepted dosage form. The recent advance in NDDS aimed for the development of dosage forms convenient to manufacturing and administration, immediate release and increased bioavailability.</em> <em>Orally disintegrating tablets are solid dosage forms containing drug tha

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Mowlavi, S., J. Engmann, A. Burbidge, et al. "In vivo observations and in vitro experiments on the oral phase of swallowing of Newtonian and shear-thinning liquids." Journal of Biomechanics 49, no. 16 (2016): 3788–95. http://dx.doi.org/10.1016/j.jbiomech.2016.10.011.

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Bayoumi, Asmaa A. "FORMULATION, OPTIMIZATION, AND EVALUATION OF SITAGLIPTIN AND SIMVASTATIN RAPIDLY DISSOLVING TABLETS." International Journal of Applied Pharmaceutics 10, no. 5 (2018): 270. http://dx.doi.org/10.22159/ijap.2018v10i5.28122.

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Objective: The scope of this work was to formulate sitagliptin and simvastatin rapidly dissolving tablets. However, simvastatin is practically insoluble in water. For improving its poor oral bioavailability and with the aim of facilitating administration to patients facing problems with swallowing rapidly dissolving tablets were preparedMethods: Tablets were prepared using superdisintegrant addition technique using croscarmellose sodium (Ac-di-sol), sodium starch glycolate (explotab) and crospovidone in different percentages. Evaluation tests such as weight variation, thickness, and content va

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Priyanka Raj G, Bhavya G, Harsha Vardhana M G, and Jashwanth Gowda H U. "A Review of Formulation Techniques and Evaluation Parameters of Fast Dissolving Tablets." Journal of Pharma Insights and Research 2, no. 4 (2024): 212–17. http://dx.doi.org/10.69613/vx91cb41.

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Fast dissolving tablets (FDTs) have gained significant popularity as a convenient and patient-friendly dosage form, particularly beneficial for pediatric, geriatric, and patients with swallowing difficulties. These tablets are formulated to disintegrate or dissolve rapidly in the oral cavity, eliminating the need for water and enhancing patient compliance. This review article provides a comprehensive overview of FDTs, covering various aspects such as their definition, ideal characteristics, advantages, and formulation techniques. The manufacturing methods employed in the development of FDTs ar

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Deepika, Biswas, Gaurav Bhaduka Dr., and Dilip Agrawal Dr. "Formulation And Evaluation of Domperidone Rapidly Disintegrating Tablets." Pharmaceutical and Chemical Journal 12, no. 3 (2025): 27–36. https://doi.org/10.5281/zenodo.15607007.

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Pediatric, geriatric and bedridden patients have difficulties swallowing tablets. Domperidone (acting through D2 receptors) is an inhibitory transmitter in g.i.t. – normally acts to delay gastric emptying when food is present in stomach. It also appears to cause gastric dilatation and LES relaxation attending nausea and vomiting. Its prokinetic action is not blocked by atropine and is based only on D2 receptor blockade in upper g.i.t. It does act on CTZ, which is responsible for its antiemetic property. In the present study, rapidly disintegrating tablets of Domperidone were formulated b

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Bahnassi, Anas, and Diana Zidan. "Formulation & Evaluation of Aceclofenac Fast Dissolving Tablets Using Foam Granulation Technique." Indo Global Journal of Pharmaceutical Sciences 02, no. 04 (2012): 342–47. http://dx.doi.org/10.35652/igjps.2012.39.

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Orally dissolving tablets (ODT) provides a patient compliance solution for patients swallowing difficulties. Foam granulation is a newer technique that promises better distribution of the granulating system and better properties of the produced tablets. Aceclofenac (anti-inflammatory and analgesic) was selected as the model drug. The poor hydrophilicity of the drug results in variable dissolution rate and poor bioavailability. In this study, we tried to prepare aceclofenac ODT using the newer technique and various types of disintegrants, glidants, and lubricants. The resulted tablets were eval

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S., Jyothi Sri* Dr. K. S. Murali Krishna D. Kusuma Ch. Uma Shankar. "FORMULATION AND IN-VITRO EVALUATION OF BENAZEPRIL MOUTH DISSOLVING FILMS." INDO AMERICAN JOURNAL OF PHARMACEUTICAL SCIENCES 05, no. 01 (2018): 552–60. https://doi.org/10.5281/zenodo.1162756.

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Oral route is most preferred route by medical practitioners and manufacturer due to highest acceptability of patients. But oral drug delivery systems still need some advancement to be made because of their some drawbacks related to particular class of patients which includes geriatric, pediatric and dysphasic patients associated with many medical conditions as they have difficulty in swallowing or chewing solid dosage forms. The aim of this is to highlight the potential role of fast dissolving drug delivery in achieving effective drug delivery of antihypertensive drug. It gives rapid absorptio

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Jain, P., A. Mishra, and A. Pathak. "PREPARATION & EVALUATION OF ORODISPERSIBLE TABLET CONTAINING ASPIRIN BY SUBLIMATION METHOD." INDIAN DRUGS 52, no. 12 (2015): 60–62. http://dx.doi.org/10.53879/id.52.12.10465.

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Orodispersible tablets are uncoated tablets which when taken into the mouth, get easily dispersed within 3 min before swallowing. they are also known as orally disintegrating tablets, mouth-dissolving tablets, rapid dissolving tablets fast-disintegrating tablets, fast-dissolving tablets. In this work, sublimation process was used to prepare orodispersible tablets of aspirin by formulating various batches using different concentration of sodium starch glycolate, camphor and cross povidone. An effort was made by using two modes, first, to increase water uptake for the fast dispersion by creating

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Cao, Weibiao, Ling Cheng, José Behar, Claudio Fiocchi, Piero Biancani, and Karen M. Harnett. "Proinflammatory cytokines alter/reduce esophageal circular muscle contraction in experimental cat esophagitis." American Journal of Physiology-Gastrointestinal and Liver Physiology 287, no. 6 (2004): G1131—G1139. http://dx.doi.org/10.1152/ajpgi.00216.2004.

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Cholinergic mechanisms are largely responsible for esophageal contraction in response to swallowing or to in vitro electrical field stimulation (EFS). After induction of experimental esophagitis by repeated acid perfusion, the responses to swallowing and to EFS were significantly reduced but contraction in response to ACh was not affected, suggesting that cholinergic mechanisms are damaged by acid perfusion but that myogenic mechanisms are not. Measurements of ACh release in response to EFS confirmed that release of ACh was reduced in esophagitis compared with normal controls. To examine facto

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Dubey, Abhay Kumar, and ,. Archana. "Development and In-Vitro Evaluation of Plantago ovata Based Rapid Disintegrating Tablets of Labetalol Hydrochloride." Journal of Drug Delivery and Therapeutics 12, no. 4 (2022): 36–42. http://dx.doi.org/10.22270/jddt.v12i4.5430.

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Objectives: To avoid swallowing problems of conventional tablets and improved patient compliance Plantago Ovata based Labetalol HCl Rapid disintegrating tablets have been prepared. Methods: Six different (F1 to F6) batches of Labetalol HCl Rapid disintegrating tablets were developed by ‘direct compression method’ using Plantago ovata as a natural super-disintegrating agent. The formulated RDT were tested for angle of repose’, densities like tapped and bulk density, Hausner’s ratio, Carr’s index like pre-compression parameters and for thickness, weight variation or weight uniformity, tablet har

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Hornby, Hannah, Mar Collado-González, Xue Zhang, et al. "Size and Number of Food Boluses in the Stomach after Eating Different Meals: Magnetic Resonance Imaging Insights in Healthy Humans." Nutrients 13, no. 10 (2021): 3626. http://dx.doi.org/10.3390/nu13103626.

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Oral processing of food results in the formation of food boluses, which are then swallowed and reach the stomach for further digestion. The number, size and surface properties of the boluses will affect their processing and emptying from the stomach. Knowledge of these parameters, however, is incomplete due to limitations of the techniques used. In this work, non-invasive magnetic resonance imaging (MRI) was used for the first time to measure boluses in the stomach a few minutes after swallowing. Three groups of nine healthy participants were fed three different meals: chicken and roasted vege

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Gaikwad, Bhavna B., Bhushan R. Rane, and Ashish S. Jain. "Formulation and Evaluation of Orodispersible Tablet of Sulindac." European Journal of Pharmaceutical Research 2, no. 3 (2022): 11–19. http://dx.doi.org/10.24018/ejpharma.2022.2.3.41.

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Oral administration of dosage form is the most recommended mode of administration, because of its self-medication, accurate dose of the drug, and ease of administration. However, trouble swallowing in geriatric patients is one major negative of this route, which can mentally disrupt patients. The goal of this study was to use the direct compression method to make orodispersible tablets of sulindac utilizing various doses of super disintegrant agents such as Sodium starch glycolate Crospovidone and Croscarmellose sodium. Three distinct super disintegrants were used to create nine formulations w

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Swarupa, Arvapalli* D. Swamy Shyamala. "ORAL DISINTEGRATION TABLETS – AN UPDATED REVIEW." INDO AMERICAN JOURNAL OF PHARMACEUTICAL SCIENCES o6, no. 03 (2019): 6926–34. https://doi.org/10.5281/zenodo.2617331.

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<em>The purpose of writing this review is Oral delivery is currently the gold standard in the pharmaceutical industry where it is regarded as the safest, most convenient and most economical method of drug delivery having the highest patient compliance. It is leads to development of orally disintegrating tablets. This disintegrates in the mouth in seconds without chewing and the need of water which is advantageous mainly for pediatrics, geriatrics and patients having difficulty in swallowing tablets and capsules. The prepared tablets were evaluated for hardness, friability, disintegration time

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Aniket, Gudur* Rishi Ramesan Dipasha Rane Afrin Darwajka Namita Bhosale. "Buccal Patches and Natural Polymers: A Synergistic Approach to Drug Delivery." International Journal of Pharmaceutical Sciences, no. 12 (December 18, 2024): 2382–91. https://doi.org/10.5281/zenodo.14511652.

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The oral mouth dissolving drug delivery system is regarded as an essential alternative to the peroral route for systemic drug administration since it is considered the most convenient, simple, and safest mode of administration. In terms of flexibility and comfort, mouth dissolving patches may be preferable than mouth dissolving tablets. The goal of this study is to design and characterize a liquorice oral mouth dissolving patch. Oral films made of Xyloglucan, PEG, and glycerine were created by solvent casting. The mechanical characteristics, swelling index, and in vitro drug release were all i

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Baliga, S. B., B. P. Manjula, and M. Geetha. "FORMULATION AND EVALUATION OF MICROSPHERE BASED ORO DISPERSIBLE TABLETS OF SUMATRIPTAN SUCCINATE." INDIAN DRUGS 54, no. 03 (2017): 28–38. http://dx.doi.org/10.53879/id.54.03.10794.

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Sumatriptan succinate (SS) is a drug used in the treatment of migraine headaches, but suffers from low patient compliance due to its unpalatable bitter taste. The purpose of the present work was to prepare taste-masked oro dispersible tablets (ODTs) of SS by incorporating drug loaded microspheres into tablets for use in patients experiencing difficulty in swallowing. Microspheres loaded with SS were prepared by solvent evaporation technique. Eudragit EPO, a pH-sensitive aminoalkylmethacrylate copolymer, was used for coating the drug particles, acetone as solvent for the polymer and light liqui

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Caille, Coline, Mariem Boukraâ, Cécile Rannou, et al. "Analysis of Volatile Compounds in Processed Cream Cheese Models for the Prediction of “Fresh Cream” Aroma Perception." Molecules 28, no. 20 (2023): 7224. http://dx.doi.org/10.3390/molecules28207224.

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Controlling flavor perception by analyzing volatile and taste compounds is a key challenge for food industries, as flavor is the result of a complex mix of components. Machine-learning methodologies are already used to predict odor perception, but they are used to a lesser extent to predict aroma perception. The objectives of this work were, for the processed cream cheese models studied, to (1) analyze the impact of the composition and process on the sensory perception and VOC release and (2) predict “fresh cream” aroma perception from the VOC characteristics. Sixteen processed cream cheese mo

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Wang, Yuhan, Jingyi Yang, Xiang Li, Jingshuo Yang, and Honglei Wang. "Optimization of the Process of Extracting Polysaccharides from Agrocybe aegerita and In Vitro Antioxidant and Anti-Aging Tests." Molecules 29, no. 21 (2024): 4992. http://dx.doi.org/10.3390/molecules29214992.

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The extraction process of crude polysaccharides from Agrocybe aegerita was optimized, and the antioxidant and anti-aging effects of the crude polysaccharides were evaluated. The optimal extraction parameters for the polysaccharide were identified using the response surface methodology. The DPPH, hydroxy radical, and superoxide anion radical scavenging capacities were evaluated to determine the antioxidant properties of the AAPs. The effects of the AAPs on the lifespan, head-swing frequency, swallowing frequency, body-bending frequency, and stress resistance of Caenorhabditis elegans were deter

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A., Kavitha and B. Krishnamoorthy. "FORMULATION AND EVALUATION OF ORODISPERSIBLE TABLETS OF DIETHYLCARBAMAZINE CITRATE." Indo American Journal of Pharmaceutical Sciences 05, no. 06 (2018): 5868–72. https://doi.org/10.5281/zenodo.1301128.

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<em>The main aim of the study was to develop or odispersible tablets of diethyl carbamazine citrate (an anthelmintic) for improving patient compliance, especially those of paediatric & geriatric categories with  difficulties  in  swallowing.  In  the  wet  granulation  method  mixture  of  sodium bicarbonate  and  tartaric  acid  along  with  agar  were  used  as  disintegrates.  The tablet formulation containing 28 mg of agar, 26 mg of sodium bicarbonate and 26 mg of tartaric acid

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