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Artículos de revistas sobre el tema "Inc Brown Group"

Autor: Grafiati

Publicado: 28 de julio de 2024

Última modificación: 31 de julio de 2025

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1

Burnett, A., N. Lalancette, and K. McFarland. "First Report of the Peach Brown Rot Fungus Monilinia fructicola Resistant to Demethylation Inhibitor Fungicides in New Jersey." Plant Disease 94, no. 1 (2010): 126. http://dx.doi.org/10.1094/pdis-94-1-0126a.

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Reduced sensitivity and resistance of Monilinia fructicola to demethylation inhibitors (DMIs; fungicide group 3) have been previously found in stone fruit orchards in Georgia, South Carolina, Ohio, and New York (2). Resistance development is a major concern because of the importance of DMIs for brown rot management. Eleven single-spore isolates, originally collected during 2006 from separate commercial peach (Prunus persica) orchards in southern New Jersey, were removed from cold storage (5°C) in early 2008 and examined in vitro for resistance to the DMI propiconazole (Orbit 3.6EC; Syngenta Cr

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2

Perez, Kimberly, Victor Pricolo, Matthew Vrees, et al. "A phase II study of complete neoadjuvant therapy in rectal cancer (CONTRE): The Brown University Oncology Group." Journal of Clinical Oncology 31, no. 4_suppl (2013): 335. http://dx.doi.org/10.1200/jco.2013.31.4_suppl.335.

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335 Background: While preoperative chemoradiation followed by surgery is the standard approach for patients (pts) with newly diagnosed clinical stage II-III rectal cancer, many are unable to tolerate postoperative adjuvant chemotherapy which may compromise disease-free and overall survival. CONTRE is a multicenter phase II study designed to determine the feasibility of administering all chemotherapy prior to surgery and to assess its impact on pathologic complete response (pCR) and complete (R0) resection Methods: Pts with T3-4 and/or N1-2 rectal cancer, staged by endorectal ultrasound (ERUS)

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3

Berenbaum, F., T. Schnitzer, A. Kivitz, et al. "FRI0378 GENERAL SAFETY AND TOLERABILITY OF SUBCUTANEOUS TANEZUMAB FOR THE TREATMENT OF OSTEOARTHRITIS: A POOLED ANALYSIS OF RANDOMIZED, PLACEBO-CONTROLLED TRIALS." Annals of the Rheumatic Diseases 79, Suppl 1 (2020): 786.1–786. http://dx.doi.org/10.1136/annrheumdis-2020-eular.268.

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Background:Tanezumab, a monoclonal antibody against nerve growth factor, is in development for the treatment of signs and symptoms of osteoarthritis (OA).Objectives:To assess the safety and tolerability of subcutaneous (SC) tanezumab in patients with OA.Methods:Data were derived from 3 randomized placebo-controlled OA trials. SC treatment (every 8 weeks for 16–24 weeks with 8–24 week follow-up) included placebo, tanezumab 2.5 mg, tanezumab 2.5/5 mg (2.5 mg at day 1 and 5 mg at week 8), and tanezumab 5 mg. Overall treatment-emergent adverse events (TEAEs) and TEAEs of abnormal peripheral sensat

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Choi, Hae Won, Seong Yeon Park, Mo Kwan Kang, and Won Jun Shon. "Comparative Analysis of Biofilm Removal Efficacy by Multisonic Ultracleaning System and Passive Ultrasonic Activation." Materials 12, no. 21 (2019): 3492. http://dx.doi.org/10.3390/ma12213492.

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The purpose of this study was to compare disinfection and the biofilm removal efficacy of the GentleWave System (Sonendo, Inc., Laguna Hills, CA, USA) with passive ultrasonic activation method. Forty-seven freshly extracted human molars were inoculated with Enterococcus faecalis and cultured for five weeks to establish biofilm. Eight molars were tested for confirmation of infection. Four of the eight teeth were not inoculated in order to provide a negative control. The remaining 39 inoculated molars were randomly separated into three treatment groups (n = 13 per group): Group 1—no treatment, G

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Zary Mostashari Shafa. "New scholarship — new serials: proceedings of the North American Serials Interest Group, Inc., 8th annual conference, June 10–13, 1993, Brown University, Providence, R.I." Library Acquisitions: Practice & Theory 20, no. 2 (1996): 241–43. http://dx.doi.org/10.1016/0364-6408(96)00005-1.

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Berenbaum, F., A. Kivitz, T. Schnitzer, et al. "FRI0392 ADVERSE EVENTS IN PATIENTS WITH OSTEOARTHRITIS TREATED WITH SUBCUTANEOUS TANEZUMAB: A POOLED ANALYSIS OF THE OVERALL POPULATION AND SELECTED SUBGROUPS FROM 3 RANDOMISED PLACEBO-CONTROLLED TRIALS." Annals of the Rheumatic Diseases 79, Suppl 1 (2020): 793.2–794. http://dx.doi.org/10.1136/annrheumdis-2020-eular.3701.

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Background:Tanezumab, a monoclonal antibody against nerve growth factor (NGF), is in development for the treatment of osteoarthritis (OA).Objectives:To assess the effects of gender, age and body mass index (BMI) on the incidence of adverse events (AEs) in patients (pts) treated with subcutaneous (SC) tanezumab in pooled data from three phase 3 OA studies. Anti-NGF therapy has been associated with joint safety events1. Here we focus on treatment emergent AEs, including abnormalities of peripheral sensation (APS).Methods:All three randomised, double-blind, placebo-controlled studies enrolled pts

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Tebas, Pablo, Joseph Agnes, Mary Giffear, et al. "571. Safety and Immunogenicity of INO-4800, a COVID-19 DNA Vaccine as a Primary Series and Booster." Open Forum Infectious Diseases 8, Supplement_1 (2021): S387—S388. http://dx.doi.org/10.1093/ofid/ofab466.769.

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Abstract Background DNA vaccines are safe, tolerable, elicit humoral and cellular responses, allow for repeated dosing over time, are thermostable at room temperature, and are easy to manufacture. We present a compilation of Phase 1 and Phase 2 data of Inovio’s US COVID-19 DNA Vaccine (INO-4800) targeting the full-length Spike antigen of SARS-CoV-2. A South Korean Phase 2 study is ongoing. Methods Participants in the open-label Phase 1 trial received 0.5 mg, 1.0 mg or 2.0 mg intradermally (ID) followed by electroporation (EP) at Days 0 and 28. An optional booster dose was administered &gt;

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Brown, Jennifer R., Rebecca J. Chan, Wei Ye, et al. "Idelalisib Plus Anti-CD20 Used Second Line Shows Improved PFS and Comparable Safety Compared to Later Line Therapy of Relapsed CLL." Blood 132, Supplement 1 (2018): 5564. http://dx.doi.org/10.1182/blood-2018-99-110853.

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Abstract Introduction: Idelalisib (IDELA) is a first-in-class PI3Kδ inhibitor that is approved for use in combination with rituximab for patients with relapsed or refractory chronic lymphoid leukemia (R/R CLL) in the United States and in combination with rituximab or ofatumumab for the same indication in the European Union. Clinical trials evaluating IDELA in the first line setting for CLL were prematurely terminated due to an increased incidence of serious adverse events (AEs) and mortality; therefore, IDELA is not indicated as a first line therapy for CLL. The safety signal observed in the t

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9

García-Macías, V., F. Martínez-Pastor, F. Martínez, et al. "192 PROBLEMS USING JC-1 TO ASSESS MITOCHONDRIAL STATUS IN BROWN BEAR (URSUS ARCTOS) SEMEN." Reproduction, Fertility and Development 17, no. 2 (2005): 246. http://dx.doi.org/10.1071/rdv17n2ab192.

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Brown bear is a highly endangered species in Spain and could benefit from biological resource banking. Currently, we are studying several reproductive aspects in order to aquire the knowledge for establishment of a germplasm bank for this species. One of our objectives is to develop adequate protocols for the evaluation of bear sperm before and after cryopreservation. We have used the fluorescent probe JC-1 protocol, which differentially stains mitochondria, according to its activity (Garner DL et al. 1997 Biol. Reprod. 57, 1401–1406). Here we describe one problem that arose using this stainin

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Ma, Huimin, Wentao Cheng, Usman Nazir, Chengfei Wang, Haiming Yang, and Xiaoli Wan. "The Efficacy of Two Mycotoxin Detoxifications on Laying Performance, Antioxidant Capacity, and Liver Damage of Laying Hens Fed Diet Naturally Contaminated with Low-Level Mycotoxins." Veterinary Sciences 12, no. 6 (2025): 520. https://doi.org/10.3390/vetsci12060520.

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This study was conducted to investigate the effects of two mycotoxin detoxifications on laying hens. A total of 360 70-week-old Hy-Line Brown laying hens were randomly divided into 1 of the 4 dietary treatment groups, with 6 replicates per group and 15 hens per replicate. The laying hens of the four treatments were fed with a basal diet (CON), a diet with naturally low-level mycotoxin contaminated corn (the levels of AFB1, ZEA, and DON in the corn of the CON group were 1.68 μg/kg, 42.75 μg/kg, and 585.40 μg/kg, respectively), replacing 73% of the corn in CON (MC), the MC diet with 1 g/kg modif

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Celik, EU, G. Yıldız, and B. Yazkan. "Comparison of Enamel Microabrasion with a Combined Approach to the Esthetic Management of Fluorosed Teeth." Operative Dentistry 38, no. 5 (2013): E134—E143. http://dx.doi.org/10.2341/12-317-c.

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SUMMARY Objective To compare in vivo the efficacy of enamel microabrasion alone or in combination with vital tooth bleaching for the management of tooth discoloration caused by fluorosis. Methods A total of 118 maxillary and mandibular fluorosed incisors and canines in 10 patients, scored from 1 to 7 according to the Tooth Surface Index of Fluorosis, were included in this study. All of the teeth were initially treated with enamel microabrasion (Opalustre, Ultradent Products Inc, South Jordan, UT, USA), and after 24 hours, an in-office bleaching technique (Opalescence Boost, Ultradent) was util

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Kondo, Y., Y. Kaneko, S. Saito, et al. "SAT0113 DISCORDANCE OF CLINICAL REMISSION AND IMAGING REMISSION BY ULTRASONOGRAPHY IN PATIENTS WITH RHEUMATOID ARTHRITIS WITH BIOLOGIC AGENTS." Annals of the Rheumatic Diseases 79, Suppl 1 (2020): 990.2–990. http://dx.doi.org/10.1136/annrheumdis-2020-eular.5048.

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Background:Residual synovitis can be detected by sensitive modalities such as ultrasonography in patients with rheumatoid arthritis in clinical remission. On the other hand, a previous study has shown that ultrasound-guided treatment provides modest benefit compared to a conventional strategy aiming clinical remission in early patients. It is still unclear how discordant clinical remission is from imaging remission by ultrasonography in patients treated with biologic agentsObjectives:To clarify the discordance between clinical remission and imaging remission in patients with rheumatoid arthrit

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Gopalakrishnapillai, Anilkumar, Anne Kisielewski, Ezio Bonvini, et al. "Effect of Ara-C on T-Cell Function and Flotetuzumab Activity in Pediatric Acute Myeloid Leukemia." Blood 134, Supplement_1 (2019): 1387. http://dx.doi.org/10.1182/blood-2019-126791.

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Acute myeloid leukemia (AML) in children still has a poor prognosis despite the use of maximally intensive chemotherapy associated with severe short-term and long-term side effects. Therefore, development of targeted therapeutics is necessary to improve outcomes in pediatric AML. CD123 (IL3RA) is overexpressed in most of pediatric AML patients (Bras et al., Cytometry B Clin Cytom, 963:134, 2019) and has been pursued as a target for immunotherapy. The efficacy of a dual affinity retargeting agent (CD123xCD3; MGD006 or flotetuzumab), was evaluated in two patient-derived xenograft models of pedia

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14

Holmes, Richard. "Ian Malcolm Brown. British Logistics on the Western Front, 1914-1919. Westport, Conn.: Praeger, dist. by Greenwood Publishing Group, Inc., Westport, Conn. 1998. Pp. xvi, 261. $65.00. ISBN 0-275-95894-9." Albion 31, no. 1 (1999): 157–58. http://dx.doi.org/10.1017/s0095139000062487.

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Woyach, Jennifer A., Amy S. Ruppert, Nyla A. Heerema, et al. "Long-Term Results of Alliance A041202 Show Continued Advantage of Ibrutinib-Based Regimens Compared with Bendamustine Plus Rituximab (BR) Chemoimmunotherapy." Blood 138, Supplement 1 (2021): 639. http://dx.doi.org/10.1182/blood-2021-153146.

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Abstract Introduction: Alliance for Clinical Trials in Oncology A041202 is a NCI National Clinical Trials Network phase 3 study (NCT01886872) comparing BR (Arm 1) with ibrutinib (Arm 2) and the combination of ibrutinib plus rituximab (Arm 3) to determine whether ibrutinib-containing regimens are superior to chemoimmunotherapy (CIT) in terms of progression-free survival (PFS), and whether rituximab adds benefit to ibrutinib therapy. Initial results showed that ibrutinib-containing regimens had superior PFS to CIT, and that rituximab added to ibrutinib did not improve PFS over ibrutinib alone. P

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Salevouris, Michael J., Robert W. Brown, Linda Frey, et al. "Book Reviews." Teaching History: A Journal of Methods 12, no. 1 (1987): 31–48. http://dx.doi.org/10.33043/th.12.1.31-48.

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Eliot Wigginton. Sometimes a Shining Moment: The Foxfire Experience-- Twenty Years in a High School Classroom. Garden City, New York: Anchor Press/ Doubleday, 1985. Pp. xiv, 438. Cloth, $19.95. Review by Philip Reed Rulon of Northern Arizona University. Eugene Kuzirian and Larry Madaras, eds. Taking Sides: Clashing Views on Controversial Issues in American History. Vol. I: The Colonial Period to Reconstruction. Guilford , Connecticut: Dushkin Publishing Group, Inc., 1985. Pp. x, 255. Paper, $8.95. Review by Jayme A. Sokolow of the National Endowment for the Humanities. Lois W. Banner. American

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WASHIL, ASAAD FAKHIR, Özcan ÖZKAN, Maysaa Ghazi Jumaa, and Husam Al-hraishawi. "DETECTION OF EPSTEIN-BARR VIRUS (EBV) IN WOMEN WITH BREAST CANCER IN IRAQ USING IN-SITU HYBRIDIZATION AND IMMUNOHISTOCHEMICAL TECHNIQUES." SOUTHERN JOURNAL OF SCIENCES 33, no. 39 (2025): 86–104. https://doi.org/10.48141/2764-5959.07.v33.n39.2025_washil_pgs_86_104.pdf.

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Background: The Epstein-Barr virus (EBV) has recently been identified in human breast cancer globally, potentially contributing to the initiation and progression of this malignancy, as well as gastric cancer, nasopharyngeal carcinoma, and bladder cancer. It has been newly associated with breast cancer. Globally, breast cancer affects more women than any other type of cancer. In Iraq, the prevalence of breast cancer is comparable. Aims: The study examined Iraqi women diagnosed with invasive ductal carcinoma (IDC) and invasive lobular carcinoma (ILC) to detect Epstein-Barr Virus Nuclear Antigen-

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Cantore, P. Lo, and N. S. Iacobellis. "First Report of Head Rot of Brassica oleracea convar. botrytis var. italica Caused by Pseudomonas fluorescens in Southern Italy." Plant Disease 91, no. 5 (2007): 638. http://dx.doi.org/10.1094/pdis-91-5-0638a.

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During the winter of 2004, symptoms were observed in commercial cauliflower (Brassica oleracea L. convar. botrytis (L.) Alef. var. italica) fields of “romanesco” type (cv. Navona) in Apulia, southern Italy. These symptoms were noted on inflorescences that were almost ready for harvest, and a bacterial etiology was suspected. In particular, the corymbs showed water-soaked and brown discolored areas which then rotted. The above alterations involved the whole inflorescences, or in some cases, only a few florets. Longitudinal sections of the symptomatic inflorescences or the single floret showed b

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Gorlov, I. F., N. V. Kalinina, and A. A. Nevzorova. "Influence of the mineral additive "Ostoferol" on productive, hematological indicators and morphology of laying hens' eggs." Agrarian-And-Food Innovations 28 (December 28, 2024): 36–47. https://doi.org/10.31208/2618-7353-2024-28-36-47.

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Purpose. Study of the influence of "Ostoferol" mineral additive on the productive, hematological indices and morphology of laying hens' eggs. Materials and Methods. The studies were conducted in the conditions of a poultry farm in the Sverdlovsk region on layers of the Hisex Brown cross, 28-29 weeks of age, in the 1st phase of egg laying. The experiment lasted 60 days. Three groups (control and two experimental) were formed from hens with signs of hypovitaminosis D. The number of poultry in each group was 100 heads. The laying hens received the mineral additive "Ostoferol" with drinking water

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Navia, Bradford, James I. Hudson, Susan L. McElroy, et al. "113 Dasotraline for the Treatment of Moderate to Severe Binge Eating Disorder in Adults: Results From a Randomized, Double-Blind, Placebo-Controlled Study." CNS Spectrums 23, no. 1 (2018): 72–73. http://dx.doi.org/10.1017/s1092852918000135.

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AbstractObjectivesBinge eating disorder (BED) is the most common eating disorder in the US, with a lifetime prevalence of 2.8%. Disturbances in reward circuitry have been implicated in its pathogenesis. Dasotraline is a novel and potent dopamine and norepinephrine reuptake inhibitor with slow absorption and a long half-life resulting in stable plasma concentrations over 24 hours with once-daily dosing. This study evaluated the efficacy and safety of flexibly-dosed dasotraline (4, 6, and 8 mg/day) vs placebo in adults with moderate to severe BED over a 12-week period (NCT02564588).MethodsKey in

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Steel, R. G., and J. F. Hasler. "298 COMPARISON OF THREE DIFFERENT PROTOCOLS FOR SUPERSTIMULATION OF DAIRY CATTLE." Reproduction, Fertility and Development 21, no. 1 (2009): 246. http://dx.doi.org/10.1071/rdv21n1ab298.

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Traditionally, successful superstimulation of cattle depended on initiating injections of gonadotrophin at mid-cycle, approximately at second follicular wave emergence. This approach limited the convenience of scheduling donors for superstimulation. With the use of intravaginal progesterone-releasing devices and estradiol 17β, superstimulation can be initiated successfully at any time of the estrous cycle. However, because estradiol cannot be legally injected into cattle in an increasing number of countries, the efficacy of GnRH as an estradiol substitute was investigated. A retrospective anal

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Boeckh, Michael, Ann Arvin, Kathleen Mullane, et al. "Immunogenicity of Inactivated Varicella Zoster Vaccine (ZVIN) in Autologous Hematopoietic Stem Cell Transplant (auto-HSCT) Recipients." Open Forum Infectious Diseases 4, suppl_1 (2017): S60. http://dx.doi.org/10.1093/ofid/ofx162.141.

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Abstract Background Recipients of auto-HSCT have an increased risk of herpes zoster (HZ) infection; however, live attenuated varicella-zoster virus (VZV) vaccine is contraindicated in these patients. In this pivotal Phase III study (V212-001; NCT01229267) inactivated VZV vaccine (ZVIN) reduced the rate of HZ infection compared with placebo (estimated vaccine efficacy, 63.8%) and was well tolerated. Immunogenicity of ZVINin recipients of auto-HSCT was assessed in the Phase III study as an exploratory objective. Methods Adults undergoing auto-HSCT were randomized to receive either ZVIN(n = 560)

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Koike, S. T., K. Kammeijer, C. T. Bull, and Doug O'Brien. "First Report of Bacterial Blight of Rutabaga (Brassica napus var. napobrassica) Caused by Pseudomonas syringae pv. alisalensis in California." Plant Disease 91, no. 1 (2007): 112. http://dx.doi.org/10.1094/pd-91-0112c.

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In 2005, commercial, organically grown rutabaga (Brassica napus var. napobrassica) in San Benito County, CA showed symptoms of a previously undescribed disease on approximately 30% of the plants. Initial symptoms consisted of small (1 to 2 mm in diameter), angular, water-soaked flecks that often were surrounded by chlorotic haloes. These flecks enlarged and coalesced into large, irregularly shaped, gray brown lesions that could be as long as 10 mm. Lesions were visible from both adaxial and abaxial leaf surfaces and generally retained the chlorotic borders. A blue-green fluorescing pseudomonad

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Tsai, Joyce, Brad Navia, Susan L. McElroy, et al. "170 Efficacy and Safety of Dasotraline in Adults with Binge-Eating Disorder: A Randomized, Double-blind, Fixed-dose Trial." CNS Spectrums 25, no. 2 (2020): 308–9. http://dx.doi.org/10.1017/s1092852920000863.

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Abstract:Background:Dasotraline is a long-acting dopamine/norepinephrine reuptake inhibitor with a PK profile characterized by slow absorption and a t½ of 47-77 hours, permitting once-daily dosing. In a previous flexible dose study, dasotraline demonstrated significant efficacy in the treatment of binge-eating disorder (BED). The aim of this confirmatory fixed-dose study was to evaluate efficacy and safety of dasotraline in the treatment of patients with BED.Methods:Patients meeting DSM-5 criteria for BED were randomized to 12 weeks of double-blind treatment with dasotraline (4 mg/d or 6 mg/d)

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Nakamura, Hiroshi, Hiroaki Ikematsu, Shozo Osera, et al. "Visual assessment of colorectal flat and depressed lesions by using narrow band imaging." Endoscopy International Open 05, no. 12 (2017): E1284—E1288. http://dx.doi.org/10.1055/s-0043-120992.

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Abstract Background and study aims Visual assessment of laterally spreading tumors non-granular type (LST-NG) and depressed lesions by narrow band imaging (NBI) without magnification has not been studied. We investigated the role of non-magnifying NBI in detecting LST-NG and type IIc lesions on colonoscopy. Patients and methods This retrospective study examined consecutive patients diagnosed as having LST-NG and/or type IIc lesions in our hospital between August 2011 and July 2013. These lesions were classified as “Brownish area (BA),” “Brown only in the margins (O-ring sign),” “Same color as

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Brown, Jennifer R., Matthew S. Davids, Jordi Rodon, et al. "Update On The Safety and Efficacy Of The Pan Class I PI3K Inhibitor SAR245408 (XL147) In Chronic Lymphocytic Leukemia and Non-Hodgkin’s Lymphoma Patients." Blood 122, no. 21 (2013): 4170. http://dx.doi.org/10.1182/blood.v122.21.4170.4170.

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Abstract Background Constitutive activation of phosphatidylinositol 3-kinase (PI3K)/ mammalian target of rapamycin (mTOR) pathway by various mechanisms has been implicated in the pathogenesis of chronic lymphocytic leukemia (CLL) and non-Hodgkin’s lymphoma (NHL). There is mounting evidence suggesting that along with PI3Kγ, PI3Kα may be involved in CLL/NHL. SAR245408 is a potent and selective inhibitor of all α, γ and δ class I PI3K isoforms. It has been shown to inhibit PI3K signaling and impact tumor growth in preclinical tumor models. The impact of SAR245408 on safety, tolerability, pharmaco

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Mato, Anthony R., John M. Pagel, Catherine C. Coombs, et al. "Pirtobrutinib, A Next Generation, Highly Selective, Non-Covalent BTK Inhibitor in Previously Treated CLL/SLL: Updated Results from the Phase 1/2 BRUIN Study." Blood 138, Supplement 1 (2021): 391. http://dx.doi.org/10.1182/blood-2021-147599.

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Abstract Background: Covalent BTK inhibitors (BTKi) have transformed the management of chronic lymphocytic leukemia/small lymphocytic lymphoma (CLL/SLL), but these treatments are not curative and many patients (pts) will require additional treatment. Covalent BTKi share pharmacologic liabilities (e.g. low oral bioavailability, short half-life) that collectively may lead to suboptimal BTK target coverage, for example in rapidly proliferating tumors with high BTK protein turnover such as accelerating CLL/SLL, ultimately manifesting as acquired resistance in some pts. To address these limitations

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Ollila, Thomas A., James Butera, Pamela C. Egan, et al. "Vincristine Sulfate Liposome Injection (VSLI) with Bendamustine and Rituximab As First-Line Therapy for Indolent B-Cell Lymphomas: A Phase 1 Study." Blood 136, Supplement 1 (2020): 15–16. http://dx.doi.org/10.1182/blood-2020-134054.

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Background: The combination of bendamustine and rituximab (BR) is frequently used as treatment for indolent B-cell lymphomas (iBCL; Rummel et al, Lancet 2013; Olszewski et al, Am J Hematol 2019). Its relatively low adverse effect profile and lack of overlapping toxicities suggest the potential for adding vincristine - another highly active anti-lymphoma agent. However, a prior trial found high rates of thrombocytopenia when standard vincristine was combined with full-dose bendamustine (Herold M, et al. J Cancer Res Clin Oncol. 2006). VSLI is a liposome-encapsulated formulation of vincristine d

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Vadillo Robredo, Goretti. "Historia de las demandas y otras acciones legales entabladas contra la industria tabaquera en los Estados Unidos." Estudios de Deusto 47, no. 1 (2015): 119. http://dx.doi.org/10.18543/ed-47(1)-1999pp119-172.

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I. Introducción. II. Demandas de particulares contra la industria tabaquera. 1. Introducción. 2. Antes de Cipollone. 3. Cipollone v. Liggett Group Inc. a. En general. b. En concreto. 4. Después de Cipollone. 5. Fumadores pasivos. II. «Class Action» v. Tabacaleras. 1. Castano v. American Tobacco Co. 2. Broin v. Philip Morris. 3. Engle v. R.J. Reynolds Tobacco, et.al. III. Demandas entabladas por los estados (Attorneys General). IV. Acuerdos extrajudiciales. Comentario sobre el preacuerdo de junio de 1997. Preacuerdo de 23 de noviembre de 1998: Multistate Master Settlement Agreement (MSA). V. Re

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Ningsih, Purnama, Sitti Rahmawati, Baharuddin Hamzah, et al. "Histology of hematoxylin–eosin and immunohistochemical diabetes rat pancreas after giving combination of moringa leaves (Moringa oleifera) and clove flower (Syzygium aromaticum) extracts." Open Access Macedonian Journal of Medical Sciences 9, A (2021): 257–62. http://dx.doi.org/10.3889/oamjms.2021.5928.

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The purpose of this study was to determine the regeneration activity of pancreatic beta cells by a combination of the ethanol extracts of Moringa leaves and Clove flower. These extracts prepared by maceration with ethanol as solvent . This is an experimental laboratory research by using post test only group design . The subject of this research is 40 white male rats of Wistar strain ( Rattus norvegicus ) and were conditioned DM by streptozotozine-nicotinamide induction . The rats randomly divided into 8 groups , and each group consisted of 5 rats . Combination dose of Moringa leaves and Clove

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Bull, C. T., A. I. Huerta, and S. T. Koike. "First Report of Blossom Blight of Strawberry (Fragaria × ananassa) Caused by Pseudomonas marginalis." Plant Disease 93, no. 12 (2009): 1350. http://dx.doi.org/10.1094/pdis-93-12-1350b.

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In 2003, a new disease was observed on commercial strawberries (Fragaria × ananassa Duch.) grown in multiple fields in Watsonville, CA. Initial symptoms consisted of brown lesions on the undersides of the sepals of strawberry flowers. The lesions coalesced and spread to upper sepal surfaces and anther bases. No leaf symptoms were observed. Fields affected with this disease appeared to have a greater number of deformed fruit, though incidence data were not collected. A gram-negative, blue-green fluorescent pseudomonad was isolated from lesions on King's medium B agar from both sepals and anther

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Potter, J. L., M. M. Roca de Doyle, M. K. Nakhla, and D. P. Maxwell. "First Report and Characterization of Rhynchosia golden mosaic virus in Honduras." Plant Disease 84, no. 9 (2000): 1045. http://dx.doi.org/10.1094/pdis.2000.84.9.1045a.

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Rhynchosia minima was suspected to be a weed host of Bean golden yellow mosaic virus (BGYMV, previously designated Bean golden mosaic virus type II). Leaf tissue that exhibited yellow mosaic foliar symptoms characteristic of a geminivirus infection was collected in the Comayagua Valley in Honduras in July 1999. Extraction of viral DNA from the symptomatic leaves was accomplished with the DNeasy Plant Mini Kit (Qiagen Inc., Valencia, CA). Subsequent viral DNA amplification was accomplished with degenerative primers for the cp gene (AV494/AC1048) (4). The 570-bp fragment was cloned into the pGEM

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Giraudo, S. Q., C. M. Kotz, M. K. Grace, A. S. Levine, and C. J. Billington. "Rat hypothalamic NPY mRNA and brown fat uncoupling protein mRNA after high-carbohydrate or high-fat diets." American Journal of Physiology-Regulatory, Integrative and Comparative Physiology 266, no. 5 (1994): R1578—R1583. http://dx.doi.org/10.1152/ajpregu.1994.266.5.r1578.

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We measured the influence of diet composition on hypothalamic neuropeptide Y (NPY) message and brown fat uncoupling protein (UCP) mRNA using different diets. Sprague-Dawley rats ate ad libitum either chow, a high-carbohydrate (HC), an intermediate-carbohydrate (IHC), a high-fat (HF), or an intermediate-fat (IHF) diet, all with equal protein content (g/kcal). The HF and IHF groups ate less food mass and, except for HC, all groups consumed similar kilocalories during the study. After 1 wk, we killed the animals and extracted total RNA from arcuate nucleus, cortex, and brown adipose tissue (BAT).

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Choquette, D., L. Bessette, L. Choquette Sauvageau, et al. "POS0057 WHICH ADVANCED TREATMENT SHOULD BE USED FOLLOWING THE FAILURE OF A FIRST-LINE ANTI-TNF IN PATIENTS WITH RHEUMATOID ARTHRITIS? 15 YEARS OF EVIDENCE FROM THE QUEBEC REGISTRY RHUMADATA™." Annals of the Rheumatic Diseases 82, Suppl 1 (2023): 239.1–239. http://dx.doi.org/10.1136/annrheumdis-2023-eular.1423.

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BackgroundSince 2000, advanced therapies (AT) have revolutionized rheumatoid arthritis (RA) treatment. Initially, TNF-targeted therapies were the only options. Then, therapies with different modes of action (OMA) appeared. Habits and medication availability often determine second-line AT choices. Research suggests that specific sequences provide better long-term effectiveness [1,2].ObjectivesEvaluate which alternative medication provides the best sustainability following first-line TNF failure.MethodsData from AT prescribed since January 2007 was extracted from RHUMADATA™. Patients were follow

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DAMAYANTI, META MAULIDA, and MEIKE RACHMAWATI. "Pre-Clinical Study: Immunohistochemical evaluation of matrix metalloproteinase-13 on rabbit (Oryctolagus cuniculus) socket healing after application of platelet-rich fibrin with and without hydroxyapatite." F1000Research 11 (August 11, 2022): 29. http://dx.doi.org/10.12688/f1000research.74094.2.

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Background: Tissue engineering technology has been used globally and proven to accelerate wound healing. This study aimed to analyse the effect of adding hydroxyapatite (HA) as a scaffold to platelet-rich fibrin (PRF) as a growth factor in accelerating the wound healing process as seen from the expression of matrix metalloproteinase-13 (MMP-13). Methods: This research is an animal experiment conducted on 18 rabbits (Oryctolagus cuniculus). Rabbits were randomly divided into the following three groups of treatment: (G1) the application of PRF group, (G2) the application of PRF+HA group and (C)

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DAMAYANTI, META MAULIDA, and MEIKE RACHMAWATI. "Pre-Clinical Study: Immunohistochemical evaluation of matrix metalloproteinase-13 on rabbit (Oryctolagus cuniculus) socket healing after application of platelet-rich fibrin with and without hydroxyapatite." F1000Research 11 (January 11, 2022): 29. http://dx.doi.org/10.12688/f1000research.74094.1.

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Background: Tissue engineering technology has been used globally and proven to accelerate wound healing. This study aimed to analyse the effect of adding hydroxyapatite (HA) as a scaffold to platelet-rich fibrin (PRF) as a growth factor in accelerating the wound healing process as seen from the expression of matrix metalloproteinase-13 (MMP-13). Methods: This research is an animal experiment conducted on 18 rabbits (Oryctolagus cuniculus). Rabbits were randomly divided into the following three groups of treatment: (G1) the application of PRF group, (G2) the application of PRF+HA group and (C)

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37

Nellenbach, Kimberly A., Nina A. Guzzetta, and Ashley C. Brown. "Differential Sialic Acid Content in Adult and Neonatal Fibrinogen Mediate Differences in Clot Polymerization." Blood 136, Supplement 1 (2020): 21–22. http://dx.doi.org/10.1182/blood-2020-139965.

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Recent studies have identified several major qualitative and quantitative differences in important hemostatic proteins between adult and neonatal humans, including the primary coagulation protein fibrinogen.Despite these differences, neonates with post-operative bleeding from procedures requiring cardiopulmonary bypass (CPB) or extracorporeal membrane oxygenation (ECMO) are treated with transfusions of adult blood products, namely adult fibrinogen. The effectiveness of such transfusions is inconsistent in neonates and often results in a deficient fibrin matrix structure which may not be suffic

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Bull, C. T., P. Goldman, and S. T. Koike. "Bacterial Blight on Arugula, a New Disease Caused by Pseudomonas syringae pv. Alisalensis in California." Plant Disease 88, no. 12 (2004): 1384. http://dx.doi.org/10.1094/pdis.2004.88.12.1384a.

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Beginning in 1995, a leaf spot disease has occasionally developed on the leafy crucifer arugula (Eruca vesicaria subsp. sativa) that is grown in coastal California as a fresh market commodity used mostly in bagged salad mixes. Initially, symptoms consist of small (<2 mm in diameter), angular, water-soaked spots that are visible from both sides of the leaf. The spots later enlarge, remain angular in shape, and turn brown to tan. A purple margin sometimes occurs around the spots. An important diagnostic feature is that this disease closely resembles downy mildew infections that have not produ

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Mirabolfathy, M., J. Z. Groenewald, and P. W. Crous. "First Report of Pilidiella granati Causing Dieback and Fruit Rot of Pomegranate (Punica granatum) in Iran." Plant Disease 96, no. 3 (2012): 461. http://dx.doi.org/10.1094/pdis-10-11-0887.

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Iran is the largest producer of pomegranate (Punica granatum) in the world, with more than 60,000 ha currently in production. In the spring of 2011, a decline and dieback of young pomegranate trees (7 to 10 years old) were observed in the Kheir area of Fars Province. Dieback and twig blight developed toward the lower part of the stem, resulting in death of aerial tree parts and growing suckers from roots. Surface-disinfected tissues of diseased plants were plated on potato dextrose agar (PDA) and malt extract agar media. Isolates were separated into two groups that had either pale green or whi

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Koike, S. T., D. M. Henderson, C. T. Bull, P. H. Goldman, and R. T. Lewellen. "First Report of Bacterial Leaf Spot of Swiss Chard Caused by Pseudomonas syringae pv. aptata in California." Plant Disease 87, no. 11 (2003): 1397. http://dx.doi.org/10.1094/pdis.2003.87.11.1397b.

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From 1999 through 2003, a previously unreported disease was found on commercial Swiss chard (Beta vulgaris subsp. cicla) in the Salinas Valley, (Monterey County) California. Each year the disease occurred sporadically throughout the long growing season from April through September. Initial symptoms were water-soaked leaf spots that measured 2 to 3 mm in diameter. As disease developed, spots became circular to ellipsoid, 3 to 8 mm in diameter, and tan with distinct brown-to-black borders. Spots were visible from the adaxial and abaxial sides. Cream-colored bacterial colonies were consistently i

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Tamer, Abdallah Helmy, Hassan Zidan Dina, and Mohamed Abdallah Ahmed. "Hypertonic saline versus mannitol in treatment of diffuse brain edema in patients with moderate and severe traumatic brain injury." Biolife 4, no. 3 (2022): 471–74. https://doi.org/10.5281/zenodo.7321837.

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<strong>ABSTRACT</strong> Background: Hyperosmolar therapy is the primary medical management strategy for brain edema and raised intracranial pressure. Objective: The aim of the work was to compare between Hypertonic saline 3% and Mannitol 20% in the treatment of diffuse brain edema after traumatic brain injury. Methods: A sample of 40 patients with diffuse brain edema after traumatic brain injury was included and divided into two groups; Group A: 20 patients were treated with hypertonic saline 3%, Group B: 20 patients were treated with mannitol 20%. Results: hypertonic saline 3% was significa

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Aljamaan, Khalid, Talal Khalid Aljumah, Saleh Aloraibi, Muhammad Absar, Giuseppe Saglio, and Zafar Iqbal. "Low Representation of ETV6-RUNX1 Fusion Oncogene in Pediatric Acute Lymphoblastic Leukemia Patients from Saudi Arabia and Strong Association with Clinical Response to Day-14 of Remission Induction Therapy." Blood 126, no. 23 (2015): 4987. http://dx.doi.org/10.1182/blood.v126.23.4987.4987.

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Abstract Abstract : Introduction: t(12; 21) leading to ETV6-RUNX1 fusion oncogene is associated with better prognosis and excellent treatment outcome in pediatric ALL (pALL) patients have good prognosis as compared to other genetic abnormalities1. Accordingly, frequency of ETV6-RUNX1 has a huge implication in treatment strategies of pALL in a given population. Different ethnic groups from various geographical regions have different frequencies of ETV6-RUNX1 ranging from 10% (Southeast Asia) to 33% (Australia) 2,3. Therefore, aim of this study was to determine ETV6-RUNX1 status of Saudi Arabian

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Kenda Šuster, Nataša, Snježana Frković Grazio, Irma Virant-Klun, Ivan Verdenik, and Špela Smrkolj. "Cancer Stem Cell–Related Marker NANOG Expression in Ovarian Serous Tumors: A Clinicopathological Study of 159 Cases." International Journal of Gynecologic Cancer 27, no. 9 (2017): 2006–13. http://dx.doi.org/10.1097/igc.0000000000001105.

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ObjectiveThe objectives of this study were to assess cancer stem cell–related marker NANOG expression in ovarian serous tumors and to evaluate its prognostic significance in relation to ovarian serous carcinoma.MethodsNANOG protein expression was immunohistochemically evaluated in the ovarian tissue microarrays of 20 patients with benign ovarian serous tumors, 30 patients with borderline ovarian serous tumors, and 109 patients with ovarian serous carcinomas, from which 106 were of high-grade and 3 of low-grade morphology Immunohistochemical reaction was scored according to signal intensity and

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Brown, Jennifer R., Bruce D. Cheson, Richard R. Furman, et al. "Patterns of Lymphocytosis in Patients with Chronic Lymphocytic Leukemia (CLL) or Small Lymphocytic Lymphoma (SLL) Treated with Idelalisib." Blood 126, no. 23 (2015): 2952. http://dx.doi.org/10.1182/blood.v126.23.2952.2952.

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Abstract Background Lymphocytosis is a known pharmacologic effect of B-cell receptor (BCR) targeted therapies used in the treatment of CLL and SLL. It has been reported that prolonged lymphocytosis after treatment with a BTK inhibitor was more common in patients (pts) with mutated immunoglobulin heavy chain variable region (IGHV) genes. Idelalisib (IDL) is a selective oral PI3Kd inhibitor. In the phase I idelalisib monotherapy (IDL-mono) trial (NCT00710528), the majority of pts with CLL/SLL experienced a transient increase in absolute lymphocyte count (ALC) accompanied by a reduction of lympha

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Brown, Jennifer R., Ian W. Flinn, Matthew S. Davids, et al. "Clinical and Biological Indicators of Duvelisib Efficacy in CLL from the Phase 3 DUOTM Study." Blood 132, Supplement 1 (2018): 1856. http://dx.doi.org/10.1182/blood-2018-99-114251.

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Abstract Introduction In CLL, the timing and selection of therapy is largely informed by disease stage, prognostic molecular features, tumor load, and patient (pt) performance status. Duvelisib (DUV) is a novel, oral, dual PI3K-δ,γ inhibitor in clinical development for the treatment of CLL/SLL, FL, and other hematologic malignancies. Results from the Phase 3 DUO study (NCT02004522) for relapsed/refractory CLL/SLL showed that DUV monotherapy resulted in statistically significant improvement over ofatumumab (OFA) monotherapy for median progression-free survival (mPFS; 13.3 vs 9.9 months (mo); p&

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Constantinou, Maria, Michael P. Vezeridis, Martin A. Weinstock, et al. "BrUOG 324: Adjuvant nivolumab and low-dose ipilimumab for stage IIC, III, and resected stage IV melanoma: A phase II Brown University Oncology Research Group trial." Journal of Clinical Oncology 36, no. 5_suppl (2018): TPS202. http://dx.doi.org/10.1200/jco.2018.36.5_suppl.tps202.

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TPS202 Background: Adjuvant ipilimumab improves survival in stage III melanoma. Adjuvant nivolumab improves progression-free survival as compared to ipilimumab with reduced toxicity. Checkpoint 067 showed that the combination of ipilimumab and nivolumab is more active in advanced melanoma than either agent alone. The Brown University Oncology Research Group sought to evaluate dual checkpoint inhibition in the adjuvant setting. This may be particularly beneficial to patients with melanoma with low PD-L1 expression. To balance safety and efficacy, the combination of low dose ipilimumab and stand

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Mota, Filipa, Camilo Ruiz-Bedoya, Elizabeth Tucker, et al. "1411. Noninvasive Assessment of Intralesional Antimicrobial Concentration-Time Profiles in Pulmonary and Central Nervous System Tuberculosis using Dynamic 18F-Pretomanid Positron Emission Tomography." Open Forum Infectious Diseases 8, Supplement_1 (2021): S789—S790. http://dx.doi.org/10.1093/ofid/ofab466.1603.

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Abstract Background Pretomanid is used in combination with bedaquiline and linezolid (BPaL regimen) in the treatment of multidrug-resistant tuberculosis (MDR-TB). However, the penetration of pretomanid in privileged sites remain unknown. Antimicrobial pharmacokinetic (PK) parameters are traditionally derived from clinical samples (blood and cerebrospinal fluid), which may not accurately represent the intralesional tissue PK, affected by drug properties, vascular supply, barrier permeability, and the microenvironment. Methods We developed 18F-pretomanid (chemically identical to pretomanid) for

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Башмаков, Дмитрий Идрисович. "МОРФОЛОГИЧЕСКИЕ ИНДЕКСЫ ЛИСТЬЕВ BETULA PENDULA ROTH. КАК ИНДИКАТОРЫ ЗАГРЯЗНЕНИЯ ПОЧВ ТЯЖЕЛЫМИ МЕТАЛЛАМИ". Российский журнал прикладной экологии, № 4 (26 грудня 2022): 28–35. http://dx.doi.org/10.24852/2411-7374.2022.4.28.35.

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Выполнено сравнение отклика локальных популяций березы повислой (Betula pendula) на факторы среды по двум морфометрическим индексам: флуктуирующей асимметрии (ФА) и ксероморфизма (ИК) листьев. Показано, что изменения значений исследованных индексов практически не зависят от концентрации тяжелых металлов (ТМ) в тканях листа и существенно обусловлены действием экзогенных факторов. Особенно сильна зависимость ФА и ИК от уровня суммарного загрязнения почв ТМ, в частности свинцом и цинком. Биоиндикационная карта г. Саранска и его окрестностей свидетельствует, что 75% исследованной территории принад

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Djunaidi, Muhammad Cholid, Pratama Jujur Wibawa, and Ratna Hari Murti. "Synthesis of A Novel Carrier Compound Thiazoethyl Methyl Eugenoxyacetate from Eugenol and Its Use in the Bulk Liquid Membrane Technique." Indonesian Journal of Chemistry 18, no. 1 (2018): 121. http://dx.doi.org/10.22146/ijc.25075.

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Research into the synthesis and use of a novel carrier compound, thiazoethyl methyl eugenoxyacetic acid (TMEAA) for selective transport of Cu(II), Cd(II) and Cr(III) metal ions in the bulk liquid membrane (BLM) technique was conducted. TMEAA was synthesized from eugenol. Eugenol was acidified into eugenoxyacetic acid and subsequently esterified using 4-methyl-5-thiazoethanol. Analysis of the result was performed using GC-MS and FTIR. The TMEAA obtained was liquid, viscous, blackish-brown and fragrant, with a yield of 88%. This compound was soluble in benzene and chloroform but insoluble in met

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Lestari, Desak Putu Oki, Analysa Analysa, Ni Wayan Armerinayanti, I. Nyoman Putu Riasa, and I. Gusti Alit Artha. "The Correlation of PD-L1 Overexpression With Tumor Budding In Cervical Carcinoma." Indonesian Journal of Cancer 18, no. 3 (2024): 266–71. http://dx.doi.org/10.33371/ijoc.v18i3.1103.

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Background: Several studies have proven the relationship between PD-L1, which is known as an immunotherapy target, and poor prognosis. The presence of a tumor budding (TB) group tumor outside the main tumor is also associated with a poor prognosis. The purpose of this study was to determine the relationship between PD-L1 and the grade of TB in cervical carcinoma. Methods: The design of this research is a case-control study with a retrospective approach. The sample is from a paraffin block of the primary cervical cancer tumor from the results of surgery in Balimed Denpasar Hospital between 2020

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