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Tesis sobre el tema "Including biology"

Autor: Grafiati

Publicado: 7 de junio de 2025

Última modificación: 2 de agosto de 2025

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1

Jones, Sadie. "HPV biology in VIN : viral biomarkers to predict response to treatment." Thesis, Cardiff University, 2016. http://orca.cf.ac.uk/93652/.

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Biology in VIN: Viral Biomarkers to Predict Response to Treatment I Summary Vulval intraepithelial neoplasia (VIN) is a condition of vulval skin that is often chronic in nature. The diagnosis is made histologically and can be delayed due to VINs variable clinical presentation. Frequently reported symptoms of pain and itching can be very distressing for patients. If left untreated, VIN has the potential to become malignant. The current standard treatment for VIN is surgical excision. However this approach is not ideal; it can be disfiguring and lead to significant psychosexual morbidity. There

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2

Podd, Frank J. W. "Medical X-ray dose reduction including adaptive image processing." Thesis, University of Surrey, 1997. http://epubs.surrey.ac.uk/842724/.

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This thesis investigates possible methods for dose reduction for one of the main contributors to medical x-ray dose, that of fluoroscopic examinations. Background information is provided on the subjects of radiation interaction mechanisms, radiation dose measures, and the health risk from medical x-rays. This illuminates a running theme of the thesis, namely the compromise between image quality and low patient dose. Possible dose reduction methods using both spatial and temporal image processing techniques are investigated. Edge detection is one of the most important sub-components of the spat

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3

Varela, Mariana. "Biology of the envelope glycoproteins of sheep betaretroviruses." Thesis, Connect to e-thesis, 2008. http://theses.gla.ac.uk/117/.

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Thesis (Ph.D.) - University of Glasgow, 2008.<br>Ph.D. thesis submitted to the Faculty of Veterinary Medicine, University of Glasgow, 2008. Includes bibliographical references. Print version also available.

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4

Benson, Lindsay Anne. "Application of circadian biology to behavioural and physiological assessments in mice." Thesis, University of Nottingham, 2016. http://eprints.nottingham.ac.uk/38836/.

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Circadian rhythms are present in all living organisms; daily oscillations of biological process from the expression of a gene to the number of times that an animal displays a given behaviour. The light/dark cycle is the primary cue that entrains these rhythms and the suprachiasmatic nuclei, within the hypothalamus are the central pacemaker which synchronises peripheral body clocks. Mice are useful circadian biology models and two peripheral circadian outputs were studied, locomotor activity and the rhythm of body temperature in a common inbred strain, the C57BL/6 mouse. The use of individually

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5

Hannay, Jonathan A. F. "Soft tissue sarcoma : biology and therapeutic correlates." Thesis, University of Glasgow, 2015. http://theses.gla.ac.uk/6988/.

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Soft tissue sarcomas (STS) comprise a heterogenenous group of greater than 50 malignancies of putative mesenchymal cell origin and as such they may arise in diverse tissue types in various anatomical locations throughout the whole body. Collectively they account for approximately 1% of all human malignancies yet have a spectrum of aggressive behaviours amongst their subtypes. They thus pose a particular challenge to manage and remain an under investigated group of cancers with no generally applicable new therapies in the past 40 years and an overall 5-year survival rate that remains stagnant a

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6

Yeung, Ka Yu. "The role of mitochondrial DNA in the tumor biology of glioblastoma multiforme and multiple myeloma." Thesis, University of Warwick, 2014. http://wrap.warwick.ac.uk/62061/.

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Cancer cells preferentially metabolise glucose via aerobic glycolysis (the Warburg effect), which is less energy efficient in teens of ATP production compared to oxidative phosphorylation (OXPHOS). Mitochondrial DNA (mtDNA) encodes proteins of the electron transfer chain and is crucial for functional OXPHOS. MtDNA exists as multiple copies in cells and, often in cancer, there is co-existence of mutant and wild-type mtDNA. There is evidence for mitochondria to contribute towards the tumor biology of multiple myeloma (MM) and glioblastoma multiforme (GBM). The mtDNA from both these cancer types

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7

Williamson, David Wayne. "Genetic and bioinformatic approaches to identify polymorphic modulators of transcription factor binding and disease phenotypes including HIV-1 viremia." Diss., Search in ProQuest Dissertations & Theses. UC Only, 2008. http://gateway.proquest.com/openurl?url_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:dissertation&res_dat=xri:pqdiss&rft_dat=xri:pqdiss:3297790.

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Thesis (Ph.D.)--University of California, San Francisco, 2008.<br>Source: Dissertation Abstracts International, Volume: 69-02, Section: B, page: 0768. Adviser: Robert W. Mahley. Includes supplementary digital materials.

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8

Bell, Hildegarde. "Effects of hypergravity on fiber type and muscle mass in ankle extensors, including a compartmentalized muscle." FIU Digital Commons, 1995. http://digitalcommons.fiu.edu/etd/1480.

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Mice (30+-3 days old) were exposed to hypergravity (4G, one hour/day). Cross-sections of ankle extensor muscles stained immunohistochemically against slow myosin (MHC) determined if hypergravity affects the distribution of slow muscle fibers. Comparisons (ANOVA) between exposed and unexposed animals show hypergravity causes increases in slow fiber density in soleus after fourteen (p=0.049) and thirty day (p=0.Ol9) exposures. Therefore, loading may induce faster development of soleus through increased slow fiber density. Slow fibers increase in plantaris in males after seven (p=0.008) and in fe

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9

Bae, Insoo. "Studies on the genomic differences between transmissible gastroenteritis virus and antigenically related coronaviruses including porcine respiratory coronavirus /." The Ohio State University, 1992. http://rave.ohiolink.edu/etdc/view?acc_num=osu148777503417647.

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10

Kerr, J. P. "Cytotoxic T cell costimulation : biology and potential for generating long-lasting immunity." Thesis, University of Southampton, 2011. https://eprints.soton.ac.uk/375471/.

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11

de, Moya Robert S. "Molecular Phylogenetic Analysis of Argynnis Fabricius (1807) including North American Speyeria Scudder (1872)." Scholarly Commons, 2016. https://scholarlycommons.pacific.edu/uop_etds/168.

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North American Speyeria butterflies are a group whose species hypotheses are confounded by shared wing color patterns between sympatric populations of closely related recognized species due to a putatively recent origin in evolutionary time. Previous studies of this group and the closely related Palearctic genus Argynnis , suggest that Speyeria is monophyletic but derived from within Argynnis . Sampling in these studies has either involved few basal Speyeria species, or too few Argynnis species (Simonsen 2006, Simonsen et al. 2006). Thus, no comprehensive phylogenetic analysis exists for all m

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12

Verissimo, Ana Raquel Andrade. "The role of Endothelial Cell Specific Chemotaxis Regulator (ECSCR) in endothelial cell biology." Thesis, University of Birmingham, 2013. http://etheses.bham.ac.uk//id/eprint/4673/.

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Angiogenesis, although a natural process, when deregulated can be associated with many human pathologies, including cancer. The endothelial cells play a crucial role in the growth and remodelling of the vasculature. A novel unique endothelial marker, endothelial cell specific chemotaxis regulator (ECSCR), has been identified and the aim of this project was to characterise its expression patterns and mechanism of action. In HUVECs the interaction with filamin A was confirmed and immunoprecipitation has pulled down several cytoskeletal proteins involved in cell movement, including moesin, that b

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13

Kenyon, Laura J. "Characteristics of genome evolution in obligate insect symbionts, including the description of a recently identified obligate extracellular symbiont." The Ohio State University, 2015. http://rave.ohiolink.edu/etdc/view?acc_num=osu1418408362.

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14

Korfi, Koorosh. "Epigenetic programming defines stem cell identity and entry into the proliferative compartment in chronic myeloid leukaemia (CML)." Thesis, University of Glasgow, 2012. http://theses.gla.ac.uk/3929/.

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Chronic myeloid leukaemia (CML) is a haematological malignancy that is identified by the presence of a fusion oncogene, BCR-ABL1, which is a constitutive tyrosine kinase. The discovery of tyrosine kinase inhibitors (TKIs) over that past decade has resulted in significantly improved survival rates and disease management in CML patients. However, a subpopulation of BCR-ABL1+ cells in the niche are found which exhibit stem cell-like features, such as self-renewal and quiescence. These CML stem cells (LSCs) are shown to be insensitive to TKI treatment and are capable of deriving the disease during

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15

Roxburgh, Patricia. "Manipulating the p53 pathway for cancer treatment." Thesis, University of Glasgow, 2013. http://theses.gla.ac.uk/4576/.

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p53 is a tumour suppressor that is dysfunctional in most cancers. In some cancers, mutation of the TP53 gene results in expression of a mutant protein or loss of p53 expression, while in others wild-type p53 is retained but there is a defect in the mechanisms that allow for the activation of p53, including, but not limited to, upregulation of p53’s negative regulators (MDM2 and MDMX). Restoration of wild-type p53 function can lead to tumour regression and is therefore an attractive anti-cancer therapy. Several small molecule compounds that activate wild-type p53 have been described, and in thi

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16

Gilligan, Lorna Catherine. "Oestrogen metabolism in colorectal cancer." Thesis, University of Birmingham, 2017. http://etheses.bham.ac.uk//id/eprint/7856/.

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Colorectal cancer (CRC) is the second most prevalent cancer. Although not typically considered a hormonally responsive malignancy, oestrogens are linked to disease risk and survival. Here, it is hypothesised that oestrogen synthesis, via steroid sulphatase (STS) and 17β-hydroxysteroid dehydrogenases (HSD17β), is promoted in CRC leading to oestrogen-driven tumour proliferation. To identify potential novel treatment targets oestrogen metabolism was characterised in CRC. Oestrogen metabolism was characterised in CRC cell lines and human colon tissue using Western blotting, qRT-PCR, STS activity a

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17

Green, Clara Emily. "Understanding shared pathogenesis between chronic obstructive pulmonary disease (COPD) and lung cancer by means of cell specific genomics." Thesis, University of Birmingham, 2018. http://etheses.bham.ac.uk//id/eprint/8230/.

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Introduction: COPD (Chronic Obstructive Pulmonary Disease) and lung cancer are related conditions associated with inflammation. Relatively little focus has been given to the endothelium, through which inflammatory cells transmigrate to reach the lung. We sought to determine if coding and non-coding alterations in pulmonary endothelium exist in COPD and lung cancer. Methods: Patients with and without COPD undergoing thoracic surgery were recruited. Pulmonary Endothelial Cells were isolated from lung and tumour and extracted RNA (ribonucleic acid) used for miRNA (micro-RNA) and mRNA (messenger R

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18

Sierra, Gonzalez Pablo. "Understanding a new role for D-mannose in modulating tumour growth and cancer therapy." Thesis, University of Glasgow, 2017. http://theses.gla.ac.uk/8945/.

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19

Whitcomb, Hilary Louise. "Bridging Post-Wildfire Communication Gaps between Managers, Researchers, and Local Communities, including a Biological Soil Crust Case Study." DigitalCommons@USU, 2017. https://digitalcommons.usu.edu/etd/5994.

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Following a wildfire, land management agencies act quickly to protect ecosystem services. We don't currently understand how post-wildfire managers make trade-off decisions in these tight timelines, or if these decisions reflect current science. Using Brunson’s (2014) social-ecological systems multi-scalar model, surveys assessed manager opinions about post-wildfire projects, perceptions of stakeholder opinions, and ability or willingness to consider new science results. Public surveys asked local citizens their opinions about post-wildfire projects. Manager perceptions were measured through se

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20

Wild, D. "Glucagon-like peptide-1 receptor imaging probes translation of molecular biology into clinical application including insulinoma and islet cell imaging." Thesis, University College London (University of London), 2011. http://discovery.ucl.ac.uk/1325641/.

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Strong over-expression of Glucagon-like Peptide-1 receptors (GLP-1-R) in human pancreatic β cells and in insulinoma provide an attractive target for imaging. This is relevant since the preoperative localisation of insulinomas remains a challenge whilst serial measurements of functional β cell mass (BCM) may improve monitoring of novel diabetes therapies such as islet cell replacement. The aim of the thesis was to develop and evaluate GLP-1-R imaging probes and translate these into clinical applications, including insulinoma and β cell imaging. After extensive preclinical evaluation (internaliz

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21

Choudury, Sarah G. Choudury. "Identification and characterization of proteins required for RNA-directed DNA Methylation, including the RNA binding protein ALY1." The Ohio State University, 2018. http://rave.ohiolink.edu/etdc/view?acc_num=osu1543508792612526.

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22

Tuttle, Matthew Alan. "In silico analysis of zebrafish leptin-a knockdown gene expression data reveals enrichment for metabolic and developmental pathways including morpholino artifacts." University of Akron / OhioLINK, 2017. http://rave.ohiolink.edu/etdc/view?acc_num=akron1492641073183086.

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23

Hepburn, Elizabeth Amanda. "The role of microvascular tumour endothelium in the recruitment of CD8+ T lymphocytes in colorectal cancer." Thesis, University of Birmingham, 2017. http://etheses.bham.ac.uk//id/eprint/7392/.

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Tumour endothelial cells (TEC) display a distinct and angiogenic phenotype. They also permit trafficking of anti-tumour CD8+ T-lymphocytes into tumour stroma. I aimed to develop and validate an isolation technique and in vitro model of primary human colorectal TEC, characterize the TEC phenotype, and investigate intratumoural micro-environmental signals regulating CD8+ T-cell recruitment by TEC. Flow cytometry, ELISA and QPCR revealed CD31, VWF, CD105, VEGFR’s, VE-Cadherin, CD13 and tumour specific marker TEM8 expression by colorectal TEC. TEC and tumour associated fibroblast (TAFB) produced h

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24

Amoroso, Richard Benjamin Couture. "Studies on the expression and function of Epstein-Barr virus encoded microRNAs in Burkitt lymphoma." Thesis, University of Birmingham, 2013. http://etheses.bham.ac.uk//id/eprint/3694/.

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Epstein-Barr virus (EBV) encodes at least 40 microRNAs (miRNAs), an important class of negative regulators that control gene expression through posttranscriptional mechanisms. However the contribution of these EBV-encoded miRNAs to the pathogenesis of virus-associated lymphomas remains poorly understood. Using newly-developed PCR assays, we first quantified the levels of viral BHRF1 and BART miRNAs in a range of EBV-positive cell lines. We show for the first time that all three BHRF1 miRNAs are abundantly expressed in Wp-restricted Burkitt lymphoma (BL) cells, but not Latency I BL cells lackin

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25

Quill, Lee. "Fragment-based screening of the oncogenic protein tyrosine phosphatase SHP2." Thesis, University of Birmingham, 2017. http://etheses.bham.ac.uk//id/eprint/7425/.

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Protein tyrosine phosphatases represent a family of signalling enzymes with emerging therapeutic potential. The cytoplasmic protein tyrosine phosphatase SHP2, encoded by the PTPN11 gene, plays a central role in the activation of downstream signalling events at multiple growth factor and cytokine receptors, and was the first oncogenic protein tyrosine phosphatase to be discovered. Aberrant SHP2 signalling underlies the pathology of numerous developmental disorders such as Noonan and LEOPARD syndrome, and is a known driver of breast cancer and myeloproliferative disease. To gain a deeper insight

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26

Cartlidge, Rachael Charlotte. "The Epstein-Barr virus BCL-2 homologues : interactions with cellular BCL-2 proteins and their role in apoptosis." Thesis, University of Birmingham, 2015. http://etheses.bham.ac.uk//id/eprint/5898/.

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Epstein-Barr virus (EBV) encodes two viral BCL-2 homologues, BHRF1 and BALF1. BHRF1 is expressed in a subset of EBV-positive Burkitt’s lymphoma (BL) tumours; as BHRF1 is highly anti-apoptotic, expression could result in treatment-resistant BL. Little is known about BALF1, including whether BALF1 is pro- or anti-apoptotic. Interactions between BHRF1 and cellular BCL-2 homologues have not been fully characterised, but previous studies have focused on BIM as a key binding partner. We stably expressed wild-type or mutant vBCL-2s in EBV-negative BL lines to investigate interactions between BHRF1 an

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27

Rudge, Felicity. "Genome-wide cDNA and RNAi screening to identify modulators of responses to a novel Wnt signalling inhibitor." Thesis, Cardiff University, 2013. http://orca.cf.ac.uk/58589/.

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Wnt/β-catenin signalling plays a central role in the regulation of multicelluar organism development and in the maintenance of tissue homeostasis in adults. Dysregulation of Wnt signalling resulting in aberrant pathway activation is a key initiating step in the development of a diverse range of cancers, including colorectal cancer, and as such is an important target for therapeutic intervention. A novel Wnt pathway inhibitor, ‘MSC’, has been identified as blocking activated Wnt signalling, specifically through inhibiting the ability of CDK8 and CDK19 to activate nuclear β-catenin/TCF-dependent

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28

Fox, Matthew David. "B cell receptor apoptosis : signalling and regulation." Thesis, University of Southampton, 2005. https://eprints.soton.ac.uk/345071/.

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29

Burdyga, Alex. "Control of cAMP signalling in the cellular migration of pancreatic ductal adenocarcinoma." Thesis, University of Liverpool, 2013. http://livrepository.liverpool.ac.uk/12081/.

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Pancreatic ductal adenocarcinoma (PDAC) is characterised by a very high mortality rate and is the 4th most common cause of cancer death (Siegel et al., 2012). The disease initially develops asymptomatically, and at the time of diagnosis patients usually have multiple metastases (Rhim et al., 2012). It would therefore be highly desirable to develop treatments which specifically impede the ability of PDAC cells to metastasise by interfering with the cellular processes responsible for efficient cellular migration. Intracellular signalling cascades, which utilise various signalling proteins, ultim

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30

Low, Carolyn M. "Genomic interactions of the transcription factor VEZF1." Thesis, University of Glasgow, 2013. http://theses.gla.ac.uk/5078/.

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VEZF1 is a highly conserved vertebrate transcription factor. VEZF1 binding sites have been reported to function in gene promoter activation, insulator barrier activity and protection from de novo DNA methylation. This study aims to identify VEZF1 binding sites across the human genome and to develop a better understanding of the gene regulatory processes mediated by VEZF1.

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31

Lee, Pearl. "The regulation of TIGAR." Thesis, University of Glasgow, 2015. http://theses.gla.ac.uk/7026/.

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TIGAR (TP53-induced glycolysis and apoptosis regulator) functions to promote antioxidant defence, with a loss of TIGAR associated with a defect in a cell’s ability to control reactive oxygen species (ROS) and resultant oxidative damage. TIGAR can function as a fructose-2,6-bisphosphatase, lowering the levels of fructose-2,6- bisphosphate, which is an activator of phosphofructokinase-1. As a consequence, TIGAR activity results in a dampening of the glycolytic pathway and, by enhancing the pentose phosphate pathway, increases cellular antioxidant capacity by promoting the generation of NADPH and

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32

Ahmad, Faizzan Syed. "A novel human stem cell platform for probing adrenoceptor signaling in iPSC derived cardiomyocytes including those with an adult atrial phenotype." Thesis, University of Oxford, 2017. http://ora.ox.ac.uk/objects/uuid:17972018-6750-4e5c-8cc9-42e9c381f531.

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Scientific research is propelled by two objectives: Understanding and recognizing the essential biology of life, and deciphering this to uncover possible therapeutics in order to improve quality of life as well as relieve pain from disease. The aim of the work described in this thesis was to dissect the fundamental requirements of induced pluripotent stem cells both in pluripotency and differentiation with a particular focus on atrial specificity. Drug targeting of atrial-specific ion channels has been difficult because of lack of availability of appropriate cardiac cells, and preclinical test

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33

Sherrill, Kyle Wayne 1967. "Potential mechanisms for apoptosis induced by both the NSAIDs and thioredoxin, including inhibition of the transcription factor NF-κB". Diss., The University of Arizona, 1997. http://hdl.handle.net/10150/282575.

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This work describes an investigation into potential mechanisms by which both the non-steroidal anti-inflammatory drugs (NSAIDs) and the redox protein thioredoxin (Trx) may modulate sensitivity to apoptosis in colon carcinoma via the transcription factor NF-κB. NSAIDs are chemopreventive against colon cancer. NSAIDs appear to inhibit tumor growth by a mechanism distinct from cyclooxygenase inhibition. All NSAIDs tested induced apoptosis in HT-29 colon cells at concentrations near their respective anti-proliferative IC₅₀ concentrations. In a search for potential apoptotic mechanisms of the NSAID

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34

Morgan, David L. "The biology of Nannatherina balstoni and Lepidogalaxias salamandroides, including comparisons with the other teleosts found in inland waters in south-western Australia." Thesis, Morgan, David L. (1999) The biology of Nannatherina balstoni and Lepidogalaxias salamandroides, including comparisons with the other teleosts found in inland waters in south-western Australia. PhD thesis, Murdoch University, 1999. https://researchrepository.murdoch.edu.au/id/eprint/42301/.

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The first aim of this thesis was to determine the length and age compositions, growth rates, reproductive biology and diets of Nannatherina balstoni and Lepidogalaxias salamandroides. Sampling for these two species of teleost, which are found predominantly in the acidic pools of the southern peat flats in the extreme south-western comer of Australia, was carried out monthly over approximately two years by using seine and dip nets and, in the case of larvae, also light traps. Nannatherina balstoni spawned at the end of their first year of life, when, on average, the males and females had reache

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35

Lawson, Jonathan Luke Done. "Genome-wide microscopy screening identifies links across processes including a conserved connection between DNA damage control and the microtubule cytoskeleton." Thesis, University of Cambridge, 2015. https://www.repository.cam.ac.uk/handle/1810/253007.

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Previous PhD students in the lab created a method for large-scale, high-content microscopy screening of a cell library consisting of over 3000 single mutant strains of the fission yeast, Schizosaccharomyces pombe. Each strain has one nonessential gene knocked-out, allowing investigation of the resulting phenotypes. I report the implementation and completion of this screen; developing methods to ensure reliable and accurate results through inclusion of many controls across multiple screening repeats. In total, over 4.5 million images from approximately 19 000 biologically independent cell popul

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36

au, matthew pember@fish wa gov, and Matthew Barrett Pember. "Characteristics of fish communites in coastal waters of north-western Australia, including the biology of the threadfin species Eleutheronema tetradactylum and Polydactylus macrochir." Murdoch University, 2006. http://wwwlib.murdoch.edu.au/adt/browse/view/adt-MU20090423.112613.

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This study was aimed at determining the characteristics of the fish assemblages in nearshore coastal waters of the remote Canning region of tropical Western Australia and to obtain sound quantitative data on crucial aspects of the biology of the two threadfin species, which are commercially and recreationally important in those waters. The community studies focused on comparing the species compositions of the fish faunas found over bare sand and in mangroves and rock pools and on elucidating the factors that influence those compositions. The population studies concentrated on exploring the her

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37

au, B. Chuwen@murdoch edu, and Benjamin Chuwen. "Characteristics of the ichthyofaunas of offshore waters in different types of estuary in Western Australia, including the biology of Black Bream Acanthopagrus butcheri." Murdoch University, 2009. http://wwwlib.murdoch.edu.au/adt/browse/view/adt-MU20100210.154423.

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This thesis has addressed the following three main areas of research. 1) The physico-chemical characteristics of eight selected estuaries on the south coast of Western Australia that represent different estuary types, 2) the ichthyofaunal characteristics of the basin and riverine regions of offshore, deeper waters of five of those estuaries and 3) aspects of the biology of the iconic Black Bream Acanthopagrus butcheri in each of those estuaries in which it was abundant. Although four of the estuaries on the south coast of Western Australia remain permanently open to the ocean, the others only

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38

Chuwen, Benjamin Michael. "Characteristics of the ichthyofaunas of offshore waters in different types of estuary in Western Australia, including the biology of black bream Acanthopagrus butcheri /." Murdoch University Digital Theses Program, 2009. http://wwwlib.murdoch.edu.au/adt/browse/view/adt-MU20100210.154423.

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39

Pember, Matthew Barrett. "Characteristics of fish communites in coastal waters of north-western Australia, including the biology of the threadfin species Eleutheronema tetradactylum and Polydactylus macrochir." Thesis, Pember, Matthew Barrett (2006) Characteristics of fish communites in coastal waters of north-western Australia, including the biology of the threadfin species Eleutheronema tetradactylum and Polydactylus macrochir. PhD thesis, Murdoch University, 2006. https://researchrepository.murdoch.edu.au/id/eprint/462/.

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This study was aimed at determining the characteristics of the fish assemblages in nearshore coastal waters of the remote Canning region of tropical Western Australia and to obtain sound quantitative data on crucial aspects of the biology of the two threadfin species, which are commercially and recreationally important in those waters. The community studies focused on comparing the species compositions of the fish faunas found over bare sand and in mangroves and rock pools and on elucidating the factors that influence those compositions. The population studies concentrated on exploring the her

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40

Pember, Matthew Barrett. "Characteristics of fish communites in coastal waters of north-western Australia, including the biology of the threadfin species Eleutheronema tetradactylum and Polydactylus macrochir." Pember, Matthew Barrett (2006) Characteristics of fish communites in coastal waters of north-western Australia, including the biology of the threadfin species Eleutheronema tetradactylum and Polydactylus macrochir. PhD thesis, Murdoch University, 2006. http://researchrepository.murdoch.edu.au/462/.

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This study was aimed at determining the characteristics of the fish assemblages in nearshore coastal waters of the remote Canning region of tropical Western Australia and to obtain sound quantitative data on crucial aspects of the biology of the two threadfin species, which are commercially and recreationally important in those waters. The community studies focused on comparing the species compositions of the fish faunas found over bare sand and in mangroves and rock pools and on elucidating the factors that influence those compositions. The population studies concentrated on exploring the her

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41

Chuwen, Benjamin. "Characteristics of the ichthyofaunas of offshore waters in different types of estuary in Western Australia, including the biology of Black Bream Acanthopagrus butcheri." Thesis, Chuwen, Benjamin (2009) Characteristics of the ichthyofaunas of offshore waters in different types of estuary in Western Australia, including the biology of Black Bream Acanthopagrus butcheri. PhD thesis, Murdoch University, 2009. https://researchrepository.murdoch.edu.au/id/eprint/1662/.

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This thesis has addressed the following three main areas of research. 1) The physico-chemical characteristics of eight selected estuaries on the south coast of Western Australia that represent different estuary types, 2) the ichthyofaunal characteristics of the basin and riverine regions of offshore, deeper waters of five of those estuaries and 3) aspects of the biology of the iconic Black Bream Acanthopagrus butcheri in each of those estuaries in which it was abundant. Although four of the estuaries on the south coast of Western Australia remain permanently open to the ocean, the others on

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42

Chuwen, Benjamin. "Characteristics of the ichthyofaunas of offshore waters in different types of estuary in Western Australia, including the biology of Black Bream Acanthopagrus butcheri." Chuwen, Benjamin (2009) Characteristics of the ichthyofaunas of offshore waters in different types of estuary in Western Australia, including the biology of Black Bream Acanthopagrus butcheri. PhD thesis, Murdoch University, 2009. http://researchrepository.murdoch.edu.au/1662/.

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This thesis has addressed the following three main areas of research. 1) The physico-chemical characteristics of eight selected estuaries on the south coast of Western Australia that represent different estuary types, 2) the ichthyofaunal characteristics of the basin and riverine regions of offshore, deeper waters of five of those estuaries and 3) aspects of the biology of the iconic Black Bream Acanthopagrus butcheri in each of those estuaries in which it was abundant. Although four of the estuaries on the south coast of Western Australia remain permanently open to the ocean, the others on

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43

Oliver, Richard John. "Quantification of cell cycle markers in oral precancer." Thesis, University of Glasgow, 1998. http://theses.gla.ac.uk/2691/.

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The overall aims of the studies were to obtain objective measures of oral precancerous lesions based upon studies of the cell cycle and to investigate these parameters as possible prognostic indicators with regard to malignant transformation of these lesions. The majority of the precancerous lesions in the present study were dysplastic. These are the lesions which cause the greatest concern clinically with regard to malignant transformation. The first part of the study investigated the S-phase, growth fraction and the relationship of these to each other and with the degree of dysplasia with th

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44

Burgoyne, Paul. "Improved dendritic cell therapy for cancer by enhancing in vivo lymph node migration using a novel chemokine-based sorting method." Thesis, University of Glasgow, 2019. http://theses.gla.ac.uk/39056/.

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Dendritic cells (DCs) are potent antigen presenting cells and are crucially involved in the induction of the adaptive immune response. Multiple DC subsets exist in the body at rest and during inflammation with unique tissue origins and development. The main function of DCs is the uptake of antigen from the peripheral tissue by endocytosis, and the transfer of this antigen to T cells within the lymph nodes (LNs) to generate an immune response against the antigen. Given the potency of the potential T cell response, DCs are an attractive cell type for therapeutic use in contexts such as cancer. O

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45

Mohammed, Noor Ahmed. "The cyto-toxicity of some chemotherapeutic drugs on liver and kidney cell lines and the protective role of Ca2+ binding proteins." Thesis, University of Birmingham, 2017. http://etheses.bham.ac.uk//id/eprint/7530/.

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Cancer Chemotherapy treatment involves the administration of drugs to patients, these drugs mainly work by interacting with the cell cycle or inhibiting DNA synthesis. Unfortunately, the toxicity of these chemotherapy drugs is severe and can have serious side-effects on different tissues and organs of the body. In chemotherapy treatment about 85% of cancer patients exhibit some degree of liver or kidney damage. Therefore, the aim of this study was to investigate the cytotoxicity of some of the most commonly used chemotherapy drugs; Methotrexate (MTX), Etoposide, Cisplatin and Doxorubicin (DOX)

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46

Maloney, Stephanie Louise. "An investigation into the regulation and expression of the tumour suppressor gene clusterin in oral, cervical and nasopharyngeal cancer." Thesis, University of Birmingham, 2010. http://etheses.bham.ac.uk//id/eprint/612/.

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Clusterin (CLU) is a multifunctional glycoprotein widely expressed as two isoforms. One isoform, sCLU is secreted, cytoplasmic and anti-apoptotic, the other, nCLU, is nuclear and pro-apoptotic. Seven genes, DKK3, TIMP1, CADM1, AKAP12, KLF4, RNASET2 and CLU were identified to be candidate tumour suppressor genes in cervical neoplasia and subsequent validation led to an evaluation of the regulation and expression of CLU at three sites of squamous cancer: the oral cavity, cervix and nasopharynx. Down-regulation of CLU was demonstrated in nasopharyngeal cancer (NPC) and oral cancer and loss of one

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47

Hollingworth, Robert. "Activation and modulation of the DNA damage response during lytic replication of Kaposi's sarcoma-associated herpesvirus." Thesis, University of Birmingham, 2017. http://etheses.bham.ac.uk//id/eprint/7641/.

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Kaposi’s sarcoma-associated herpesvirus (KSHV) is the causative agent of several human malignancies. Herpesviruses are known to modulate cellular pathways responsible for the recognition and repair of DNA lesions, collectively known as the DNA damage response (DDR). Here it is demonstrated that lytic reactivation of KSHV in B cells results in activation of the ATM and DNA-PK kinases that regulate the response to DNA double-strand breaks (DSBs). This DDR does not depend on amplification of viral DNA and results in phosphorylation of downstream proteins involved in DNA repair, cell cycle regulat

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48

Hollinshead, Katy Elizabeth Rose. "Metabolic rewiring in response to genetic and environmental preturbations in cancer." Thesis, University of Birmingham, 2016. http://etheses.bham.ac.uk//id/eprint/6989/.

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Cancer cells reprogram their metabolism to supply biosynthetic and bioenergetic demands of rapid proliferation. Microenvironmental changes, such as hypoxia, further influence tumour metabolism, driving malignancy. Recent identification of cancer-associated mutations in succinate dehydrogenase (SDH), fumarate hydratase and isocitrate dehydrogenase (IDH) have shown that genetic alterations can directly alter tumour cell metabolism, and may be required for malignant transformation. Mutations in these metabolic enzymes promote tumorigenesis by hijacking the adaptive response to hypoxia. Understand

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49

Alholle, Abdullah. "Genetic and epigenetic alterations of sarcoma." Thesis, University of Birmingham, 2017. http://etheses.bham.ac.uk//id/eprint/7301/.

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Primary malignant bone tumours are rare cancers that are characterised by different genetic and epigenetic alterations. A functional epigenomic approach was combined with the Illumina HumanHT-12.v4-BeadChip expression microarray in three Ewing Sarcoma (ES) cell lines to identify genome-wide functional methylation changes in these cells and ES primary samples. This study revealed eight frequently methylated genes in ES patients’ samples, where NPTX2 and PHF11 promoter methylation was associated with poor patient prognosis. The second methylation study involved genome-wide DNA methylation profil

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50

Hosie, Louise Christine. "Characterisation of CMV CD8+T-cell memory-inflation to immediate early HLA-C restricted targets and the potential of CMV as a vaccine vector for cancer therapy." Thesis, University of Birmingham, 2017. http://etheses.bham.ac.uk//id/eprint/7410/.

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CMV CD8+T-cell memory-inflation can occupy up to 50% of the total CD8+ T cell pool. Studies using an MHC class I immunevasion-deleted strain revealed novel peptide-epitopes across the virus genome both in-frame and translated in a non-canonical manner. This study functionally and phenotypically characterised CD8+T-cells responding to these CMV-derived epitopes with age. They were found to be frequent component of the in vivo repertoire dedicated towards HCMV during latency. A HLA-Cw*0702-restricted immunodominant CD8+T-cell response that accumulated within elderly donors was identified to reac

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