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Artículos de revistas sobre el tema "INDOLENT PRECURSOR"

Autor: Grafiati
Publicado: 11 de marzo de 2023

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1

Pinto-Lopes, Pedro, Francisco Adao Fonseca, Roberto Silva, Pedro von Hafe, and Elsa Fonseca. "Indolent systemic mastocytosis limited to the bone: a case report and review of the literature." Sao Paulo Medical Journal 131, no. 3 (2013): 198–204. http://dx.doi.org/10.1590/1516-3180.2013.1313460.

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CONTEXT Systemic mastocytosis is defined as a clonal disorder of mast cells and their precursor cells and is currently classified as a myeloproliferative neoplasm. Its clinical course has a wide spectrum, ranging from indolent disease, with normal life expectancy, to highly aggressive disease, associated with multisystemic involvement and poor overall survival. The aim of this study was to report a case of indolent systemic mastocytosis, focusing on the diagnostic challenges, with a review of the literature. CASE REPORT A 79-year-old Caucasian woman with osteoporosis was evaluated at the Emerg
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2

Canberk, Sule. "Precursor and borderline lesions of the thyroid (indolent lesions of epithelial origin): from theory to practice." Gland Surgery 9, no. 5 (2020): 1724–34. http://dx.doi.org/10.21037/gs-20-429.

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Lussier, Tyler, Natalie Schoebe, and Sabine Mai. "Risk Stratification and Treatment in Smoldering Multiple Myeloma." Cells 11, no. 1 (2021): 130. http://dx.doi.org/10.3390/cells11010130.

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Smoldering multiple myeloma is a heterogeneous asymptomatic precursor to multiple myeloma. Since its identification in 1980, risk stratification models have been developed using two main stratification methods: clinical measurement-based and genetics-based. Clinical measurement models can be subdivided in three types: baseline measurements (performed at diagnosis), evolving measurements (performed over time during follow-up appointments), and imaging (for example, magnetic resonance imaging). Genetic approaches include gene expression profiling, DNA/RNA sequencing, and cytogenetics. It is impo
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4

Marchegiani, Giovanni, Stefano Andrianello, Tommaso Pollini, et al. "Natural History of Intraductal Papillary Mucinous Neoplasm of the Pancreas Reappraisal of the Indolent Precursor of Pancreatic Cancer." Journal of the American College of Surgeons 227, no. 4 (2018): e37-e38. http://dx.doi.org/10.1016/j.jamcollsurg.2018.08.099.

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Purdy, Adam, Firas Ido, and Deborah Stahlnecker. "Diffuse Idiopathic Pulmonary Neuroendocrine Cell Hyperplasia (DIPNECH): A Case of Indolent Pulmonary Nodules Diagnosed with Robotic-Assisted Navigational Bronchoscopy." Case Reports in Pulmonology 2021 (December 10, 2021): 1–4. http://dx.doi.org/10.1155/2021/6312296.

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Diffuse idiopathic pulmonary neuroendocrine cell hyperplasia (DIPNECH) is an atypical pulmonary disorder with limited understanding. Given the rare nature of this disease, it is essential to obtain adequate tissue pathology to confirm the diagnosis. This disease is mainly diagnosed in middle-aged, nonsmoking females, and it is now accepted as a precursor lesion to pulmonary carcinoid tumors. DIPNECH presents with characteristic radiographic and histologic findings, but its diagnosis, management, and prognosis are often underrecognized and poorly understood. Those with symptoms may present with
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6

Garcia-Montero, Andres C., Maria Jara-Acevedo, Ivan Alvarez-Twose, et al. "KIT D816V Mutation Positive Bone Marrow Mesenchymal Stem Cells in Indolent Systemic Mastocytosis Are Associated with Disease Progression." Blood 126, no. 23 (2015): 4058. http://dx.doi.org/10.1182/blood.v126.23.4058.4058.

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Abstract PURPOSE: Multilineageinvolvement of bone marrow (BM) hematopoiesis by the somatic KIT D816V mutation is present in a subset of adult indolent systemic mastocytosis (ISM) patients in association with a poorer prognosis. Here we investigated the potential involvement of BM mesenchymal stem cells (MSC) from ISM patients by the KIT D816V mutation and its potential impact on disease progression and outcome. METHODS: The KIT D816V mutation was investigated in highly-purified BM MSC and other BM cell populations from 83 ISM patients followed for a median of 116 months. MC clonality was furth
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7

Marchegiani, Giovanni, Stefano Andrianello, Tommaso Pollini, et al. "The natural history of intraductal papillary mucinous neoplasms of the pancreas: Reappraisal of the indolent precursor of pancreatic cancer." Pancreatology 18, no. 4 (2018): S2—S3. http://dx.doi.org/10.1016/j.pan.2018.05.011.

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8

Marchegiani, G., S. Andrianello, T. Pollini, et al. "The natural history of intraductal papillary mucinous neoplasm of the pancreas: Reappraisal of the indolent precursor of pancreatic cancer." HPB 20 (September 2018): S195. http://dx.doi.org/10.1016/j.hpb.2018.06.051.

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9

López, Cristina, Pablo Mozas, Armando López-Guillermo, and Sílvia Beà. "Molecular Pathogenesis of Follicular Lymphoma: From Genetics to Clinical Practice." Hemato 3, no. 4 (2022): 595–614. http://dx.doi.org/10.3390/hemato3040041.

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Follicular lymphoma (FL), a generally indolent disease that derives from germinal center (GC) B cells, represents around 20–25% of all new lymphomas diagnosed in Western countries. The characteristic t(14;18)(q32;q21) translocation that places the BCL2 oncogene under control of the immunoglobulin heavy-chain enhancer occurs in pro- or pre-B cells. However, additional secondary alterations are required for the development of overt FL, which mainly affects genes involved in epigenetic and transcriptional regulation, signaling and B cell differentiation, the BCR/NF-κB pathway, and proliferation/a
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10

Khanlari, Mahsa, and Jennifer R. Chapman. "Follicular lymphoma: updates for pathologists." Journal of Pathology and Translational Medicine 56, no. 1 (2022): 1–15. http://dx.doi.org/10.4132/jptm.2021.09.29.

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Follicular lymphoma (FL) is the most common indolent B-cell lymphoma and originates from germinal center B-cells (centrocytes and centroblasts) of the lymphoid follicle. Tumorigenesis is believed to initiate early in precursor B-cells in the bone marrow (BM) that acquire the t(14;18)(q32;q21). These cells later migrate to lymph nodes to continue their maturation through the germinal center reaction, at which time they acquire additional genetic and epigeneticabnormalities that promote lymphomagenesis. FLs are heterogeneous in terms of their clinicopathologic features. Most FLs are indolent and
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11

Zhang, QiGuo, Jian Ou-Yang, and Rong-Fu Zhou. "Clinical and Experimental Features of Natural Killer Cell Leukemias in a Chinese Population: A Single Center Experience of 10 Years." Blood 118, no. 21 (2011): 4892. http://dx.doi.org/10.1182/blood.v118.21.4892.4892.

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Abstract Abstract 4892 Leukemia of natural killer (NK) cell lineage is rare which affects Asian population preferentially. Here 10 Chinese patients with NK cell leukemia were retrospectively evaluated. Among them 7 man and 3 women, the middle age was 47 years (range 22–57 years). Aggressive NK cell leukemias were finally diagnosed in 7 patients, myeloid/NK cell precursor acute leukemias in 2 patients and NK-CLPD in 1 patient. Pronounced extramedullary involvements (breast mass, multiple subcutaneous nodes and eye rectus muscle mass) were the main manifestation in 2 myeloid/NK cell precursor ac
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12

Oben, Bénedith, Guy Froyen, Kylee H. Maclachlan, et al. "Whole-Genome Sequencing Reveals Evidence of Two Biologically and Clinically Distinct Entities: Progressive Versus Stable Myeloma Precursor Disease." Blood 136, Supplement 1 (2020): 47–48. http://dx.doi.org/10.1182/blood-2020-136403.

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Introduction Multiple myeloma (MM) is consistently preceded by an asymptomatic expansion of clonal plasma cells, clinically recognized as monoclonal gammopathy of undetermined significance (MGUS) or smoldering multiple myeloma (SMM). Here, we present the first comprehensive whole-genome sequencing (WGS) analysis of patients with MGUS and SMM. Methods To characterize the genomic landscape of myeloma precursor disease (i.e. SMM and MGUS) we performed WGS of CD138-positive bone marrow mononuclear samples from 32 patients with MGUS (N=18) and SMM (N=14), respectively. For cases with low cellularit
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13

Corinaldesi, Giorgio, and Christian Corinaldesi. "Myelodisplastic Syndrome: Is It Associated or Is It a Precursor of Myeloid Malignancies?." Blood 110, no. 11 (2007): 4592. http://dx.doi.org/10.1182/blood.v110.11.4592.4592.

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Abstract Myelodisplastic syndrome (MDS) is a clonal haematopoietic stem cells disorder considered a pre-leukemic disease (about 30% of MDS turn into acute myeloid leukaemia (AML)) which is frequently associated with cytogenetic abnormalities and chromosomal instability: monosomy 7 or 7q - syndrome, 5q- syndrome, trisomy 8, inv(16), t (8;21), t (15;17), t (12;21), t (9;11), or sub microscopic DNA mutation of gene such as RAS, p53, FLT3, HSPA9, FMS and refractory cytopenias, with dysmyelopoiesis and increased apoptosis. We have identified 15 people aged between 54/67 years with MDS and we have e
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14

Ivry, Sam L., Giselle M. Knudsen, Francesco Caiazza, et al. "The lysosomal aminopeptidase tripeptidyl peptidase 1 displays increased activity in malignant pancreatic cysts." Biological Chemistry 400, no. 12 (2019): 1629–38. http://dx.doi.org/10.1515/hsz-2019-0103.

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Abstract Incidental detection of pancreatic cysts has increased dramatically over the last decade, but risk stratification and clinical management remain a challenge. Mucinous cysts are precursor lesions to pancreatic cancer, however, the majority are indolent. Current diagnostics cannot identify mucinous cysts that harbor cancer or reliably differentiate these lesions from nonmucinous cysts, which present minimal risk of malignant progression. We previously determined that activity of two aspartyl proteases was increased in mucinous cysts. Using a global protease activity profiling technology
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15

Sarkozy, Clementine, Shaocheng Wu, Katsuyoshi Takata, et al. "Abstract A19: Integrated single cell analysis reveals co-evolution of malignant B cells and the tumor microenvironment in transformed follicular lymphoma." Blood Cancer Discovery 3, no. 5_Supplement (2022): A19. http://dx.doi.org/10.1158/2643-3249.lymphoma22-a19.

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Abstract Introduction: Histological transformation from follicular lymphoma (FL) to aggressive B-cell lymphoma (tFL) is a disease course altering event linked to poor prognosis for affected patients. From a biological point of view, it is paradigmatic of disease dynamics with distinct clinical stages that project onto genetically and phenotypically divergent states. Aim: By applying a series of high-dimensional single cell (sc)RNA and DNA profiling techniques, we aimed to characterize the clonal and phenotypic evolution of tumor B cells and to reveal dynamic interactions with components of the
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16

Chowdhury, Rajdip, and Abraham Mendoza. "N-Hydroxyphthalimidyl diazoacetate (NHPI-DA): a modular methylene linchpin for the C–H alkylation of indoles." Chemical Communications 57, no. 37 (2021): 4532–35. http://dx.doi.org/10.1039/d1cc01026c.

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The insertion of conventional diazocompounds into indoles are still limited by the custom carbene precursors, catalysts and manipulation of the products required. Herein, we address these shortcomings with a redox-active carbene precursor (NHPI-DA).
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17

Brock, Ethan J., Ryan M. Jackson, Julie L. Boerner, et al. "Sprouty4 negatively regulates ERK/MAPK signaling and the transition from in situ to invasive breast ductal carcinoma." PLOS ONE 16, no. 5 (2021): e0252314. http://dx.doi.org/10.1371/journal.pone.0252314.

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Breast ductal carcinoma in situ (DCIS) is a non-obligate precursor of invasive ductal carcinoma (IDC). It is still unclear which DCIS will become invasive and which will remain indolent. Patients often receive surgery and radiotherapy, but this early intervention has not produced substantial decreases in late-stage disease. Sprouty proteins are important regulators of ERK/MAPK signaling and have been studied in various cancers. We hypothesized that Sprouty4 is an endogenous inhibitor of ERK/MAPK signaling and that its loss/reduced expression is a mechanism by which DCIS lesions progress toward
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18

Bahrami, Armita, Jae Y. Ro, and Alberto G. Ayala. "An Overview of Testicular Germ Cell Tumors." Archives of Pathology & Laboratory Medicine 131, no. 8 (2007): 1267–80. http://dx.doi.org/10.5858/2007-131-1267-aootgc.

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Abstract Context.—More than 90% of testicular neoplasms originate from germ cells. Testicular germ cell tumors (GCTs) are a heterogeneous group of neoplasms with diverse histopathology and clinical behavior. Objective.—To help the readers distinguish various subtypes of GCTs, to highlight the clinical manifestations and pathologic features of these tumors, and to review several newly developed immunohistochemical markers for GCTs. Data Sources.—Review of the pertinent literature and our experience. Conclusions.—The etiology of GCTs is largely unknown. Cytogenetic studies suggest a different pa
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19

Gay, G., R. Rouillon, J. Bernillon, and J. Favre-Bonvin. "IAA biosynthesis by the ectomycorrhizal fungus Hebeloma hiemale as affected by different precursors." Canadian Journal of Botany 67, no. 8 (1989): 2235–39. http://dx.doi.org/10.1139/b89-285.

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The effect of different precursors, aromatic amino acids, or intermediates of the shikimate pathway (pathway for aromatic amino acids biosynthesis), on indole-3-acetic acid (IAA) synthesis by the ectomycorrhizal fungus Hebeloma hiemale was studied. This fungus did not release detectable amounts of IAA when cultivated on a medium containing no precursor or supplemented with 1 mM phenylalanine, 1 mM tyrosine or 1 mM shikimic acid. IAA accumulation in culture filtrates was low (0.5 μmol per flask) when the medium was supplemented with 1 mM anthranilic acid. The fungus released 1.6 μmol of IAA whe
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20

Abdel-Hay, Karim M., Tarek S. Belal, Younis Abiedalla, et al. "Gas Chromatography–Mass Spectrometry (GC–MS) and Gas Chromatography–Infrared (GC–IR) Analyses of the Chloro-1-n-pentyl-3-(1-naphthoyl)-Indoles: Regioisomeric Cannabinoids." Applied Spectroscopy 73, no. 4 (2018): 433–43. http://dx.doi.org/10.1177/0003702818809998.

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The analytical differentiation of the indole ring regioisomeric chloro-1- n-pentyl-3-(1-naphthoyl)-indoles is described in this report. The regioisomeric chloroindole precursor compounds, N- n-pentyl chloroindole synthetic intermediates, and the target chloro-substituted naphthoylindoles showed the equivalent gas chromatographic elution order based on the position of chlorine substitution on the indole ring. The regioisomeric chloro-1- n-pentyl-3-(1-naphthoyl)-indoles yield electron ionization mass spectra having equivalent major fragments resulting from cleavage of the groups attached to the
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21

Dutta, Ankit K., Jean-Baptiste Alberge, Elizabeth D. Lightbody, et al. "Abstract 640: Genome sequencing of circulating multiple myeloma cells for minimally invasive molecular characterization of precursor disease pathology." Cancer Research 82, no. 12_Supplement (2022): 640. http://dx.doi.org/10.1158/1538-7445.am2022-640.

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Abstract Introduction: Multiple myeloma (MM) develops from indolent stages monoclonal gammopathy of undetermined significance (MGUS) and smoldering multiple myeloma (SMM). Precursor conditions are incidentally diagnosed and require invasive bone marrow (BM) biopsies for complete characterization, highlighting the urgent need for improved early detection methods. Minimally invasive blood biopsies to measure circulating multiple myeloma cells (CMMCs) as markers of MM disease development are a promising solution to this unmet need. Here, we present our novel method CatchTheFISH, for whole genome
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22

Golub, Danielle, Peter C. Pan, Benjamin Liechty, et al. "PATH-41. POLYMORPHOUS LOW-GRADE NEUROEPITHELIAL TUMOR OF THE YOUNG WITH FGFR3-TACC3 FUSION MIMICKING HIGH-GRADE GLIOMA: CASE REPORT AND SERIES OF HIGH-GRADE CORRELATES." Neuro-Oncology 23, Supplement_6 (2021): vi124. http://dx.doi.org/10.1093/neuonc/noab196.493.

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Abstract BACKGROUND Polymorphous low-grade neuroepithelial tumor of the young (PLNTY) is a recently-described entity that can occasionally histologically and molecularly mimic high-grade glioma. The histologic and molecular features that predict aggressive behavior in FGFR3-TACC3 altered tumors are unclear. CASES We present a rare case of an indolent neuroepithelial neoplasm in a 59-year-old female with imaging initially suggestive of high-grade glioma and analyze common molecular features between this case and a series of high-grade gliomas. After total resection, pathology of the case patien
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23

Musilova, Katerina, Jan Devan, Katerina Cerna, et al. "miR-150 downregulation contributes to the high-grade transformation of follicular lymphoma by upregulating FOXP1 levels." Blood 132, no. 22 (2018): 2389–400. http://dx.doi.org/10.1182/blood-2018-06-855502.

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Follicular lymphoma (FL) is a common indolent B-cell malignancy with a variable clinical course. An unfavorable event in its course is histological transformation to a high-grade lymphoma, typically diffuse large B-cell lymphoma. Recent studies show that genetic aberrations of MYC or its overexpression are associated with FL transformation (tFL). However, the precise molecular mechanisms underlying tFL are unclear. Here we performed the first profiling of expression of microRNAs (miRNAs) in paired samples of FL and tFL and identified 5 miRNAs as being differentially expressed. We focused on on
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24

Kuckländer, Uwe, and Udo Bastian. "Darstellung und Oxidation von 2-(2,5-Dihydroxy-phenyl)-ethylamin-Derivaten, II / Synthesis and Oxidation of 2-(2,5-Dihydroxyphenyl)-ethylamine Derivatives, II." Zeitschrift für Naturforschung B 42, no. 12 (1987): 1567–77. http://dx.doi.org/10.1515/znb-1987-1214.

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Abstract2,5-Dihydroxyphenylethylamine derivatives 8a,b; 14; 19a,b and 25a,b,c are synthesized and oxidized to indole 9a, indolines 15 and 18a,b as well as 24a,b,c. Quantitative oxidation of hydroquinones yields the 2-(aminoethyl)quinones 30a as free base and 30d-f; 27a,b and the hydrochlorides 28a,b. Quinone 30a is reduced to indoline 29 and acetylated to 3-acylindole 32, transformed by heating to indole 23 and in acetic acid to the dimeric indole 31. 32 is synthesized unequivocally from 33 and 34. The course of the reaction is discussed and the formation of indolines is explained by cyclisati
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25

Carr, Norman J., Theresa S. Emory, and Leslie H. Sobin. "Epithelial Neoplasms of the Appendix and Colorectum." Archives of Pathology & Laboratory Medicine 126, no. 7 (2002): 837–41. http://dx.doi.org/10.5858/2002-126-0837-enotaa.

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Abstract Context.—Carcinomas of the appendix are usually well-differentiated mucinous adenocarcinomas that tend to produce pseudomyxoma peritonei and do not show metastatic spread until late in the disease process. In contrast, adenocarcinomas of the colon and rectum rarely result in pseudomyxoma peritonei and frequently metastasize, even if mucinous and well differentiated. These differences in behavior may be reflected by differences at the molecular level. Objectives.—To examine adenocarcinomas and their precursor lesions (adenomas) of the appendix and colorectum and to determine whether di
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26

Cortese, Matthew J., Wei Wei, and Brian T. Hill. "Outcomes of Active Surveillance Versus Initial Treatment for Nodular Lymphocyte Predominant Hodgkin Lymphoma: A National Cancer Database (NCDB) Analysis of 2,480 Patients." Blood 136, Supplement 1 (2020): 29–30. http://dx.doi.org/10.1182/blood-2020-142828.

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Introduction Nodular Lymphocyte Predominant Hodgkin Lymphoma (NLPHL) is a unique and clinically distinct subtype of Hodgkin lymphoma (HL), comprising approximately 5% of all HL cases with an annual incidence of about 1-2 cases per million. Compared with classical HL (cHL), NLPHL is more likely to present with limited stage and a more indolent clinical course. Despite these favorable traits, systemic chemoimmunotherapies and/or radiation are often used for initial treatment. Deaths directly from NLPHL are uncommon, with mortality in these patients often attributable to treatment-related toxicit
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27

Golantsov, Nikita, Alexey Festa, Alexey Varlamov, and Leonid Voskressensky. "Revision of the Structure and Total Synthesis of Topsentin C." Synthesis 49, no. 11 (2017): 2562–74. http://dx.doi.org/10.1055/s-0036-1588731.

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An efficient synthetic approach to access (indol-3-yl)ethane-1,2-diamines with a protecting group at the indole N atom from readily available 3-(2-nitrovinyl)indoles is reported. This approach includes solvent-free conjugate addition of O-pivaloylhydroxylamines to 1-Boc-3-(2-nitrovinyl)indoles followed by mild reduction of the adducts. The obtained (indol-3-yl)ethane-1,2-diamines are convenient synthetic precursors for several classes of marine alkaloids. The first total synthesis of racemic topsentin C, a secondary metabolite from Hexadella sp., based on this approach is reported. The initial
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28

Ferri-Borgogno, Sammy, Sugata Barui, Amberly M. McGee, et al. "Paradoxical Role of AT-rich Interactive Domain 1A in Restraining Pancreatic Carcinogenesis." Cancers 12, no. 9 (2020): 2695. http://dx.doi.org/10.3390/cancers12092695.

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Background & Aims: ARID1A is postulated to be a tumor suppressor gene owing to loss-of-function mutations in human pancreatic ductal adenocarcinomas (PDAC). However, its role in pancreatic pathogenesis is not clear despite recent studies using genetically engineered mouse (GEM) models. We aimed at further understanding of its direct functional role in PDAC, using a combination of GEM model and PDAC cell lines. Methods: Pancreas-specific mutant Arid1a-driven GEM model (Ptf1a-Cre; KrasG12D; Arid1af/f or “KAC”) was generated by crossing Ptf1a-Cre; KrasG12D (“KC”) mice with Arid1af/f mice and
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29

Kareddula, Aparna, Daniel J. Medina, Whitney Petrosky, et al. "The role of chromodomain helicase DNA binding protein 1 (CHD1) in promoting an invasive prostate cancer phenotype." Therapeutic Advances in Urology 13 (January 2021): 175628722110224. http://dx.doi.org/10.1177/17562872211022462.

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Background: Prostate cancer (PCa) phenotypes vary from indolent to aggressive. Molecular subtyping may be useful in predicting aggressive cancers and directing therapy. One such subtype involving deletions of chromodomain helicase DNA binding protein 1 ( CHD1), a tumor suppressor gene, are found in 10–26% of PCa tumors. In this study, we evaluate the functional cellular effects that follow CHD1 deletion. Methods: CHD1 was knocked out (KO) in the non-tumorigenic, human papillomavirus 16 (HPV16)-immortalized prostate epithelial cell line, RWPE-1, using CRISPR/Cas9. In vitro assays such as T7 end
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30

Marsch, Nils, Mario Kock, and Thomas Lindel. "Study on the synthesis of the cyclopenta[f]indole core of raputindole A." Beilstein Journal of Organic Chemistry 12 (February 23, 2016): 334–42. http://dx.doi.org/10.3762/bjoc.12.36.

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The raputindoles from the rutaceous treeRaputia simulansshare a cyclopenta[f]indole partial structure the synthesis of which is subject of this investigation. An efficient route to a series of 1,5-di(indol-6-yl)pentenones was developed via Mo/Au-catalyzed Meyer–Schuster rearrangement of tertiary propargylic alcohol precursors. However, none of the enones underwent the desired Nazarov cyclization to a cyclopenta[f]indole. More suitable were 6-hydroxyallylated indolines which gave good yields of cyclopenta[f]indolines after treatment with SnCl4, as soon as sterically demanding β-cyclocitral addu
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31

Manoni, Elisabetta, Assunta De Nisi, and Marco Bandini. "New opportunities in the stereoselective dearomatization of indoles." Pure and Applied Chemistry 88, no. 3 (2016): 207–14. http://dx.doi.org/10.1515/pac-2016-0101.

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AbstractThe regio- and stereoselective dearomatization of indoles is realized for the first time by combining readily available indolyl precursors and electron-rich allenes, namely allenamides and aryloxyallenes. Inter- as well as intramolecular condensations were realized under gold and Brønsted acid catalysis providing a range of densely functionalized indoline and indolenine cores in high yields and excellent stereochemical outcome. Chemodivergent reaction profiles (Micheal-type addition vs. [2+2]-cycloaddition) were realized by a tailored design of both reaction conditions and functionaliz
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32

Tschumper, Renee C., Tait D. Shanafelt, Neil E. Kay, and Diane F. Jelinek. "Characterization of Long Non-Coding RNAs in Chronic Lymphocytic Leukemia: Evidence for Association with Disease Progression in Trisomy 12 Patients." Blood 124, no. 21 (2014): 3281. http://dx.doi.org/10.1182/blood.v124.21.3281.3281.

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Abstract BACKGROUND: Chronic lymphocytic leukemia (CLL) is a heterogeneous B cell malignancy with patients being categorized into disease subsets based on several key biologic parameters, e.g., mutation status (mutated, M; or unmutated, UM) of the immunoglobulin heavy chain variable region (IGHV), acquired chromosomal abnormalities, and expression of CD38 and CD49d. Furthermore, about one third of CLL patients express stereotyped B cell receptors and/or may acquire high risk common mutations in genes such as NOTCH1 and SF3B1 suggesting ongoing genetic evolution as drivers of disease developmen
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33

Nagorsen, Dirk, Gerhard Zugmaier, Peter Kufer, et al. "Transient Laboratory Findings Upon First Dosing with T-Cell Engaging BiTE® Antibody Blinatumomab in Non-Hodgkin Lymphoma Patients." Blood 114, no. 22 (2009): 4798. http://dx.doi.org/10.1182/blood.v114.22.4798.4798.

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Abstract Abstract 4798 Blinatumomab is a single-chain bispecific antibody construct with specificity for CD19 and CD3 belonging to the class of bispecific T cell engager (BiTE®). It has shown high response rates as single agent after treatment of patients with indolent and mantle cell lymphoma and B-precursor acute lymphocytic leukemia. We here report from an ongoing phase 1 trial in non-Hodgkin lymphoma patients on transient laboratory findings seen upon start of continuous i.v. infusion of blinatumomab. The vast majority of adverse events (AEs) during 4-8 weeks of infusion occurred within th
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34

Eiring, Anna M., Paolo Neviani, Ramasamy Santhanam, et al. "Requirement of the E2F3 Transcription Factor for BCR/ABL Leukemogenesis." Blood 110, no. 11 (2007): 33. http://dx.doi.org/10.1182/blood.v110.11.33.33.

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Abstract Several RNA binding proteins (RBPs) have been implicated in the progression of chronic myelogenous leukemia (CML) from the indolent chronic phase to the aggressively fatal blast crisis. In the latter phase, expression and function of specific RBPs are altered at transcriptional or post-translational levels by the increased constitutive kinase activity of the BCR/ABL oncoprotein, resulting in enhanced resistance to apoptotic stimuli, growth advantage and differentiation arrest of CD34+ CML blast crisis (CML-BC) progenitors. In the current study, we identified by RIP (RNA immunoprecipit
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35

Goggiamani, Antonella, Antonia Iazzetti, Antonio Arcadi, et al. "Synthesis of Indole/Benzofuran-Containing Diarylmethanes through Palladium-Catalyzed Reaction of Indolylmethyl or Benzofuranylmethyl Acetates with Boronic Acids." Synthesis 54, no. 03 (2021): 741–53. http://dx.doi.org/10.1055/s-0041-1737275.

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AbstractThe palladium-catalyzed synthesis of indole/benzofuran-containing diarylmethanes starting from indolylmethyl or benzofuranylmethyl acetates with boronic acids has been investigated. The success of the reaction is influenced by the choice of precatalyst: with indolylmethyl acetates the reaction works well with [Pd(η3-C3H5)Cl]2/XPhos while with benzofuranylmethyl acetates Pd2(dba)3/XPhos is more efficient. The good to high yields and the simplicity of the experimental procedure make this protocol a versatile synthetic tool for the preparation of 2- and 3-substituted indoles and 2-benzo[b
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36

Bennis, Youssef, Yan Cluet, Dimitri Titeca-Beauport, et al. "The Effect of Sevelamer on Serum Levels of Gut-Derived Uremic Toxins: Results from In Vitro Experiments and A Multicenter, Double-Blind, Placebo-Controlled, Randomized Clinical Trial." Toxins 11, no. 5 (2019): 279. http://dx.doi.org/10.3390/toxins11050279.

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High serum levels of gut-derived uremic toxins, especially p-cresyl sulfate (pCS), indoxyl sulfate (IS) and indole acetic acid (IAA), have been linked to adverse outcomes in patients with chronic kidney disease (CKD). Sevelamer carbonate could represent an interesting option to limit the elevation of gut-derived uremic toxins. The aim of the present study was to evaluate the adsorptive effect of sevelamer carbonate on different gut-derived protein-bound uremic toxins or their precursors in vitro, and its impact on the serum levels of pCS, IS and IAA in patients with CKD stage 3b/4. For the in
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37

Kreher, Richard P., та Gerald Dyker. "Struktur und Reaktivität von isoanellierten heterocyclischen Systemen mit Anπ- und (4n+2)π-Elektronen, XII [1]. 2-tert-Butyl-4-methyl-2,4-dihydropyrrolo[3,4-b]indole: Tricyclische Hetarene mit isoanellierten Pyrrolringen / Structure and Reactivity of Isoannelated Heterocyclic Systems with 4nπ- and (4n+2)π-Electrons, XII [1] 2-terr-Butyl-4-methyl-2,4-dihydropyrrolo[3,4-b]indoles: Tricyclic Hetarenes with Isoannelated Pyrrole Rings". Zeitschrift für Naturforschung B 42, № 4 (1987): 473–77. http://dx.doi.org/10.1515/znb-1987-0414.

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2-tert-Butyl-4-methyl-2,4-dihydropyrrolo[3,4-b]indole (4a) has been prepared via selective reduction of 2-rm-butyl-4-methyl-2,4-dihydropyrrolo[3,4-b]indol-l(2H)-one or -3(2H)-one 5 and 6 with diisobutylaluminiumhydride. The same precursors 5 and 6 can be transformed into 2-tert-butyl-4-methyl-2,4-dihydropyrrolo[3,4-b]indoles (4b) and (4c) bearing a methoxy group in 1- or 3-position via a two step procedure consisting in O-alkylation and CH-deprotonation. NMR Investigations afford an insight into the structure of the stable tricyclic hetarenes.
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38

Edlefsen, Kerstin Lara, Anneclaire De Roos, and Andrea LaCroix. "Application of the InterLymph Consortium’s Proposed Classification of Lymphoid Neoplasms for Epidemiologic Research to a Large, Nationwide Health Study: Experience in the Women’s Health Initiative." Blood 112, no. 11 (2008): 4669. http://dx.doi.org/10.1182/blood.v112.11.4669.4669.

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Abstract Large cohort studies, such as the Women’s Health Initiative, have traditionally grouped hematopoietic neoplasms (HPN) into disease categories including multiple myeloma (MM), non-Hodgkin lymphoma (NHL), Hodgkin lymphoma (HL), and leukemia, however this may not allow for optimal distinction of biologically relevant associations. The 2001 World Health Organization (WHO) classification of HPN represents the current gold standard classification scheme, and has been incorporated into the International Classification of Disease for Oncology, Third Edition (ICD-O-3). In 2007, the Internation
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39

Nadel, Bertrand. "Early Steps of Follicular Lymphoma Pathogenesis." Blood 128, no. 22 (2016): SCI—5—SCI—5. http://dx.doi.org/10.1182/blood.v128.22.sci-5.sci-5.

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Abstract Follicular lymphoma (FL) is the second most common non-Hodgkin lymphoma in the Western world, generally characterized by a disseminated disease at diagnosis, an indolent clinical course and recurrent, increasingly chemo-resistant relapses. Overt FL is preceded by an insidious phase of asymptomatic growth and might emerge from common precursor clones (CPCs), evolving over decades, and which might participate to subsequent relapses. Consequently, the cell of origin remains ambiguous. From the clinical standpoint, morphological, histological and molecular evidences all indicate that FL r
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40

Pirog, T. P., D. V. Piatetska, N. O. Klymenko, and G. O. Iutynska. "Ways of Auxin Biosynthesis in Microorganisms." Mikrobiolohichnyi Zhurnal 84, no. 2 (2022): 57–72. http://dx.doi.org/10.15407/microbiolj84.02.057.

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Among plant hormones, auxins, in particular indole-3-acetic acid (IAA), are the most studied and researched. Almost all groups of soil microorganisms, both plant-associated and non-plant-associated bacteria, fungi, and phytopathogenic microorganisms are capable of producing auxins. The development of preparations for crop production is directly related to the production of bacterial strains with high auxin-synthesizing potential, which is possible only with a full understanding of the ways of regulation and synthesis of auxins in bacteria. The synthesis of auxins in microorganisms can take pla
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41

Sholihin, H. Hayat. "SINTESIS 7-FORMILINDOL SEBAGAI BAHAN DASAR PEMBENTUK KATALIS EPOKSIDASI BARU (SYNTHESIS OF 7-FORMYLINDOLE AS PRECURSOR OF NEW EPOXIDATION CATALYSTS)." Jurnal Pengajaran Matematika dan Ilmu Pengetahuan Alam 2, no. 1 (2015): 78. http://dx.doi.org/10.18269/jpmipa.v2i1.396.

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Manganese (III) salen complexes have been reported as epoxidation catalysts. It is caused a major breakthrough in the enantioselective epoxidation of alkenes into epoxide compounds. This catalyst was synthesized from salicylaldehyde derivatives. Based on the structure, salicylaldehyde is an isosteric nature of 7-folmylindole, consequently opened the door to an array of fascinating and versatile ligand systems, and offer tremendous scope for molecular designe, because of the greatly enhanced capacity for substitution of indoles compared with phenols. Initial target of the project to synthesize
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42

Bettanin, Luana, Filipe Penteado, Luiz H. Dapper, and Eder J. Lenardão. "Selenocyanation of Indoles Promoted by Visible Light." Chemistry Proceedings 2, no. 1 (2020): 29. http://dx.doi.org/10.3390/eccs2020-07562.

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We developed a promising synthetic methodology for the regioselective photocatalyzed 3-selenocyanation of indoles, employing potassium selenocyanate (KSeCN) and a blue LED light. The 3-selanylindoles have been emerging as a potentially bioactive class of compounds and already have demonstrated anti-inflammatory, antinociceptive and anticancer properties. There are in the literature several methodologies for their preparation; for example, applying intermolecular cyclization with Se-based electrophilic species. Therefore, it is of interest to seek innovative and effective methodologies to selec
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43

Audrito, Valentina, Sara Serra, Davide Brusa, et al. "Extracellular Nicotinamide Phosphoribosyltransferase (NAMPT) Shapes the CLL Microenvironment Promoting Macrophage M2 Polarization Via a Non-Enzymatic Mechanism." Blood 124, no. 21 (2014): 3316. http://dx.doi.org/10.1182/blood.v124.21.3316.3316.

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Abstract Cancer-associated microenvironment provides to malignant cells the right cocktail of signals to increase survival, reprogram their metabolism and escape the control of the immune system. Nicotinamide phosphoribosyltransferase (NAMPT) is the only human enzyme that metabolizes nicotinamide, the main NAD precursor, in a rate-limiting step in NAD biosynthesis. Beside this canonical activity, NAMPT can be secreted in the extracellular milieu (eNAMPT), where it exerts cytokine/adipokine-like actions in different tumor models, as well as in acute and chronic inflammatory-metabolic diseases.
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44

Chen, Qing-An, Wei-Song Zhang, and Yan-Cheng Hu. "Isoprene: A Promising Coupling Partner in C–H Functionalizations." Synlett 31, no. 17 (2020): 1649–55. http://dx.doi.org/10.1055/s-0040-1707172.

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Five-carbon dimethylallyl units, such as prenyl and reverse-prenyl, are widely distributed in natural indole alkaloids and terpenoids. In conventional methodologies, these valuable motifs are often derived from substrates bearing leaving groups, but these processes are accompanied by the generation of stoichiometric amounts of by-products. From an economical and environmental point of view, the basic industrial feedstock isoprene is an ideal alternative precursor. However, given that electronically unbiased isoprene might undergo six possible addition modes in the coupling reactions, it is dif
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45

Bodemann, René Roberto, Peter Rahfeld, Magdalena Stock, et al. "Precise RNAi-mediated silencing of metabolically active proteins in the defence secretions of juvenile leaf beetles." Proceedings of the Royal Society B: Biological Sciences 279, no. 1745 (2012): 4126–34. http://dx.doi.org/10.1098/rspb.2012.1342.

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Allomones are widely used by insects to impede predation. Frequently these chemical stimuli are released from specialized glands. The larvae of Chrysomelina leaf beetles produce allomones in gland reservoirs into which the required precursors and also the enzymes are secreted from attached gland cells. Hence, the reservoirs can be considered as closed bio-reactors for producing defensive secretions. We used RNA interference (RNAi) to analyse in vivo functions of proteins in biosynthetic pathways occurring in insect secretions. After a salicyl alcohol oxidase was silenced in juveniles of the po
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46

Tahri, Sabrin, Tarek H. Mouhieddine, Robert A. Redd, et al. "Clonal Hematopoiesis Is Associated with Increased Risk of Progression of Asymptomatic Waldenström Macroglobulinemia." Blood 138, Supplement 1 (2021): 2678. http://dx.doi.org/10.1182/blood-2021-149711.

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Abstract Introduction Clonal hematopoiesis (CH) is associated with adverse outcomes in patients with non-Hodgkin lymphoma (NHL) and multiple myeloma undergoing autologous stem cell transplantation. Still, its implications for patients with indolent NHL have not been well studied. Here, we report the prevalence of CH in patients with Waldenström Macroglobulinemia (WM) and its association with clinical outcomes. Methods We retrospectively reviewed clinical data of 602 patients with IgM monoclonal gammopathy of undetermined significance (MGUS), smoldering WM (SWM), and WM who had clinical next-ge
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47

Kaur, Banni Preet, Jasneet Kaur, and Swapandeep Singh Chimni. "Arenesulfonyl indole: new precursor for diversification of C-3 functionalized indoles." RSC Advances 11, no. 4 (2021): 2126–40. http://dx.doi.org/10.1039/d0ra09133b.

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Arenesulfonyl indole has emerged as an efficient scaffold to provide direct access to C-3 substituted indole derivativesviavinylogous imine intermediate generated by elimination of arenesulfinic group under basic conditions.
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48

Kaur, Banni Preet, Jasneet Kaur, and Swapandeep Singh Chimni. "Arenesulfonyl indole: new precursor for diversification of C-3 functionalized indoles." RSC Advances 11, no. 4 (2021): 2126–40. http://dx.doi.org/10.1039/d0ra09133b.

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Arenesulfonyl indole has emerged as an efficient scaffold to provide direct access to C-3 substituted indole derivatives via vinylogous imine intermediate generated by elimination of arenesulfinic group under basic conditions.
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49

Manoharan, Dhinesh kumar. "Synthesis, Characterization and Evaluation of Anti-inflammatory Activity of Novel Indoline Derivatives." JOURNAL OF ADVANCES IN CHEMISTRY 12, no. 12 (2016): 4557–63. http://dx.doi.org/10.24297/jac.v12i12.4826.

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Series of indoline derivatives were synthesized using N-(4-aminophenyl) indoline-1-carbothiamide as a precursor. The structures of synthesized compounds were confirmed by FT-IR, 1H-NMR, 13C-NMR and LC-MS. The in vitro anti-inflammatory activity of synthesized indoline derivatives were examined by standard anti-denaturation assay. The compounds 4a (IC50 = 62.2 µg/ml) and 4b (IC50 = 60.7 µg/ml) showed potent inhibition on protein denaturation. The compounds 5a (IC50 = 97.8 µg/ml) exhibits moderate inhibition on protein denaturation
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50

Vincent, Guillaume, Natacha Denizot, Régis Guillot, and Cyrille Kouklovsky. "N-Iodosuccinimide-Mediated Oxidative Coupling of Indoles and Phenols: A Synthetic Study toward the Benzofuroindoline Moiety of Bipleiophylline." Synthesis 50, no. 24 (2018): 4823–28. http://dx.doi.org/10.1055/s-0036-1592002.

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We report our efforts to apply an N-iodosuccinimide-mediated dearomative oxidative coupling of indoles and phenols to benzo­furoindoline-containing polycyclic scaffolds related to the natural product bipleiophylline. Suitable conditions from N-substituted indoles are developed and applied to the synthesis of a hexacyclic model starting from a tetracyclic ABCE precursor.
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