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Literatura académica sobre el tema "Infection aerogene"

Autor: Grafiati

Publicado: 4 de junio de 2021

Última modificación: 9 de febrero de 2022

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Artículos de revistas sobre el tema "Infection aerogene"

Yahya, Esam Bashir, Fauziah Jummaat, A. A. Amirul, A. S. Adnan, N. G. Olaiya, C. K. Abdullah, Samsul Rizal, M. K. Mohamad Haafiz y H. P. S. Abdul Khalil. "A Review on Revolutionary Natural Biopolymer-Based Aerogels for Antibacterial Delivery". Antibiotics 9, n.º 10 (28 de septiembre de 2020): 648. http://dx.doi.org/10.3390/antibiotics9100648.

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A biopolymer-based aerogel has been developed to become one of the most potentially utilized materials in different biomedical applications. The biopolymer-based aerogel has unique physical, chemical, and mechanical properties and these properties are used in tissue engineering, biosensing, diagnostic, medical implant and drug delivery applications. Biocompatible and non-toxic biopolymers such as chitosan, cellulose and alginates have been used to deliver antibiotics, plants extract, essential oils and metallic nanoparticles. Antibacterial aerogels have been used in superficial and chronic wound healing as dressing sheets. This review critically analyses the utilization of biopolymer-based aerogels in antibacterial delivery. The analysis shows the relationship between their properties and their applications in the wound healing process. Furthermore, highlights of the potentials, challenges and proposition of the application of biopolymer-based aerogels is explored.

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Thiolas, Aurélie, Claude Bollet, Bernard La Scola, Didier Raoult y Jean-Marie Pagès. "Successive Emergence of Enterobacter aerogenes Strains Resistant to Imipenem and Colistin in a Patient". Antimicrobial Agents and Chemotherapy 49, n.º 4 (abril de 2005): 1354–58. http://dx.doi.org/10.1128/aac.49.4.1354-1358.2005.

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ABSTRACT Enterobacter aerogenes is an agent of hospital-acquired infection that exhibits a remarkable resistance to β-lactam antibiotics during therapy. Five successive isolates of E. aerogenes infecting a patient and exhibiting a multiresistance phenotype to β-lactam antibiotics and fluoroquinolones were investigated. Among these clinical strains, four presented resistant phenotypes during successive imipenem and colistin treatments. The involved resistance mechanisms exhibited by the successive isolates were associated with alterations of the outer membrane that caused a porin decrease and lipopolysaccharide modifications.

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Ulubaş Işık, Dilek, Ahmet Yagmur Bas, Ferit Kulali, Beyza Ozcan, Sezin Unal, Husniye Yucel y Nihal Demirel. "Nosocomial Infection Outbreak with Enterobacter aerogenes at a Neonatal Intensive Care Unit and Its Outcomes". Journal of Pediatric Infectious Diseases 14, n.º 05 (28 de mayo de 2019): 223–27. http://dx.doi.org/10.1055/s-0039-1691780.

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Objective Health care associated infections (HAIs) in the neonatal intensive care unit (NICU) are a significant cause of neonatal morbidity and mortality. Enterobacter aerogenes, a gram-negative bacterium, rarely causes HAI in the pediatric and NICUs. We report the case of a HAI outbreak of E. aerogenes in an NICU and discuss the clinical spectrum and outcome of the affected preterm newborns and successful prevention measures. Materials and Methods A retrospective study was conducted in a level III NICU of Etlik Zubeyde Hanım Women's Health Teaching and Research Hospital. The infants with blood cultures positive for E. aerogenes during the outbreak were enrolled. Perinatal risk factors, laboratory findings, symptoms, treatment, and prognosis were recorded. Clinical applications and prevention measures were identified. Results A preterm infant of 27 weeks of gestation who was diagnosed on the eighth postnatal day was the initial case of the reported outbreak of health care associated E. aerogenes infection. Subsequently, 12 more infants were diagnosed in the next 3 months. Infants' mean gestational age was 27.1 ± 2.3 weeks, and mean birthweight was 902 ± 161 g. The clinical symptoms at presentation were respiratory distress, sclerema, circulatory failure, and shock, which appeared at a mean age of 7.6 ± 5.8 days. Analysis of E. aerogenes strains revealed that all strains were of the same clonal type. Eight patients died in follow-up due to E. aerogenes septicemia during this outbreak. The mean interval between the onset of symptoms and death was 1.5 ± 1 days. Conclusion Outbreaks of health care associated E. aerogenes infection result in a high mortality rate among very low birthweight infants. Awareness of adjustable risk factors and preventive measures to control the outbreak decreases both morbidity and mortality.

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Tuon, Felipe F., Camila Scharf, Jaime L. Rocha, Juliette Cieslinsk, Guilherme Nardi Becker y Lavinia N. Arend. "KPC-producing Enterobacter aerogenes infection". Brazilian Journal of Infectious Diseases 19, n.º 3 (mayo de 2015): 324–27. http://dx.doi.org/10.1016/j.bjid.2015.01.003.

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Mardhia, Mardhia, Mahyarudin Mahyarudin y Abror Irsan. "Antibiotic Sensitivity Pattern Among Diabetic Outpatients with Urinary Tract infection in Pontianak". Microbiology Indonesia 14, n.º 3 (30 de septiembre de 2020): 1. http://dx.doi.org/10.5454/mi.14.3.1.

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Diabetic patients are associated with a higher risk of infection. The research purposed to identify antibiotic susceptibility patterns among diabetic outpatients with urinary tract infection in Pontianak. An experimental study was performed for 13 bacterial isolates of diabetic outpatients with urinary tract infection in the Clinic of Diabetes Mellitus, Sultan Syarif Mohamad Alkadrie Hospital, Pontianak. The disc diffusion method was used to perform the susceptibility of antibiotics to the bacterial isolates. Among 13 isolates, the most common causative agent of urinary tract infection was Escherichia coli (53.85%), followed by Pseudomonas aeruginosa (30.77%). Klebsiella spp and Enterobacter aerogenes were 7.69%. Most isolates of bacteria of the study had a high sensitivity to Cefepime (92.31%), then followed by Levofloxacin, Amikacin, and Meropenem for 84.62%. The study revealed low sensitivity of bacteria to Amoxicillin/Clavulanate, Co-Trimoxazole, Cefazoline and Ceftriaxone (30.77%, 23.08 %, 23.08%, 23.08%, respectively). All bacterial isolates had high resistance to Ampicillin. Moreover, multidrug resistance observed among bacterial isolates. Keywords: antibiotic susceptibility, diabetes, urinary tract infections

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HUANG, FANG, SHUANG LI, LAN LOU, JUNJUN MO y HAO XU. "Comparative Genomic Analysis and Phenotypic Characterization of Bronchoscope-Associated Klebsiella aerogenes". Polish Journal of Microbiology 70, n.º 3 (septiembre de 2021): 409–12. http://dx.doi.org/10.33073/pjm-2021-038.

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Bronchoscopes have been linked to outbreaks of nosocomial infections. The phenotypic and genomic profiles of bronchoscope-associated Klebsiella aerogenes isolates are largely unknown. In this work, a total of 358 isolates and 13 isolates were recovered from samples after clinical procedures and samples after decontamination procedures, respectively, over the five months. Antimicrobial susceptibility testing found seven K. aerogenes isolates exhibiting a low-level resistance to antimicrobial agents. Among seven K. aerogenes isolates, we found five sequence types (STs) clustered into three main clades. Collectively, this study described for the first time the phenotypic and genomic characteristics of bronchoscope-associated K. aerogenes.

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Qin, Xiaohua, Yang Yang, Fupin Hu y Demei Zhu. "Hospital clonal dissemination of Enterobacter aerogenes producing carbapenemase KPC-2 in a Chinese teaching hospital". Journal of Medical Microbiology 63, n.º 2 (1 de febrero de 2014): 222–28. http://dx.doi.org/10.1099/jmm.0.064865-0.

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Carbapenems are first-line agents for the treatment of serious nosocomial infections caused by multidrug-resistant Enterobacteriaceae. However, resistance to carbapenems has increased dramatically among Enterobacteriaceae in our hospital. In this study, we report clonal dissemination caused by carbapenem-resistant Enterobacter aerogenes (CREA). In 2011, CREA was identified from 12 patients admitted to the neurosurgical ward. All 12 clinical isolates were non-susceptible to cefotaxime, ceftazidime, cefoxitin, ertapenem, imipenem or meropenem. All isolates carried the gene encoding Klebsiella pneumoniae carbapenemase-2 (KPC-2), except for the isolate E4. However, a remarkably lower expression level of the porin OmpF was detected in the non-KPC-2-producing isolate E4 on SDS-PAGE compared with the carbapenem-susceptible isolate. Epidemiological and molecular investigations showed that a single E. aerogenes strain (PFGE type A), including seven KPC-2-producing clinical isolates, was primarily responsible for the first isolation and subsequent dissemination. In a case-control study, we identified risk factors for infection/colonization with CREA. Mechanical ventilation, the changing of sickbeds and previous use of broad-spectrum antibiotics were identified as potential risk factors. Our findings suggest that further studies should focus on judicious use of available antibiotics, implementation of active antibiotic resistance surveillance and strict implementation of infection-control measures to avoid the rapid spread or clonal dissemination caused by carbapenem-resistant Enterobacteriaceae in healthcare facilities.

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Garna, Herry. "Catheter Related Infections in Pediatric Patients". Paediatrica Indonesiana 33, n.º 5-6 (21 de enero de 2019): 108–14. http://dx.doi.org/10.14238/pi33.5-6.1993.108-14.

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During a 9-month prospective study, from August, 1988 to April, 1989, a total number of 4328 hospitalized pediatric patients at the Department of Child Health, Padjadjaran University, Hasan Sadikin General Hospital Bandung, were observed to identify skin and soft tissue nosocomial infections (not included postoperative), especially catheter related injections. The gastroentestinal tract was the most frequent site of nosocomial infections (44.3%), then subsequently followed by skin infection (22.6%), bacteremia (16.3%) and urinary tract infection (14.1%). The most frequent cause of nosocomial skin infections like phlebitis was IVFD occurring in 82 out of 93 patients (88.2%). The overall phlebitis attact rate was 4.2% . When the duration of infusion is devided into 3 groups of 0-36 hours, 37-72 hours and ≥ 73 hours, then it becomes clear that the longer the duration of infusion, the higher the attack rate (x2=8.07, p<0.05). Klebsiella pneumonia seemed to be the pathogen most frequently associated with nosocomial skin infections (26. 7%), followed by Enterobacter aerogenes (20.0%), and then E. coli, Ps. aeruginosa and S. aureus 13.3% each. It could be concluded that the risk of contracting phlebitis from JVFD with a duration of ≥ 73 hours was. 1.9 times higher than that of less than 72 hours.

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Matsas O. Yu., Mychalchuk G. A., Tsaryova O. M., Mulkina O. I. y Slobodyanyuk O. M. "THE USE OF LABORATORY DIAGNOSTIC METHODS FOR THE ETIOLOGICAL INTERPRETATION OF ACUTE INTESTINAL INFECTIONS DURING THE WINTER PERIOD". World Science 2, n.º 1(41) (31 de enero de 2019): 4–6. http://dx.doi.org/10.31435/rsglobal_ws/31012019/6297.

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The study analyzed the epidemiological situation of acute intestinal infections in the winter. Surveyed 98 patients. Bacteriologically, pathogenic and conditionally pathogenic bacteria cultures were isolated in 33.7%, conditionally pathogenic cultures prevailed: Staphylococcus aureus - 23.5%, Enterococcus aerogenes - 20.5%, Klebsiella pneumoniae - 20.5%, Citrobacter freundii - 14.7%, Salmonella enteritidis - 11.7%, Proteus vulgaris - 5.8%, and the heteropathogenic Escherichia coli O142 was detected in 2.9%. Specific fragments of viral RNA in 37.6% were identified by the molecular-biological method, Rotavirus A dominated - 55.2%, Norovirus 2 genotype was found in 39.4%. More often, the infection was caused by only one pathogen. Etiological factor is not defined in 33.7%.

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Rabevazaha, Ny Ando A., Vonintsoa L. Rahajamanana, Todisoa N. Andriatahina, Elsa H. Rakotojoelimaria, Andrianina H. Ranivoson y Annick L. Robinson. "Epidemiological and bacteriological profile of neonatal bacterial infections seen in hospital pediatric in Antananarivo". International Journal of Research in Medical Sciences 7, n.º 12 (27 de noviembre de 2019): 4443. http://dx.doi.org/10.18203/2320-6012.ijrms20195184.

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Background: Neonatal bacterial infection is one of the leading causes of new-born morbidity and mortality. Bacterial ecology is not known in our unit, no study has been devoted to this subject. This work aimed to determine the germs responsible for neonatal bacterial infections and their level of sensitivity to the usual antibiotics.Methods: This is a retrospective descriptive study conducted in the Neonatology Department from January 1, 2018 to April 30, 2019 (16 months) including all newborns under 29 days hospitalized during the study period and possessing positive bacteriological results regardless of the site of collection (blood, urine, cerebrospinal fluid).Results: The diagnosis of neonatal infection was confirmed in 47 cases, i.e. 26.1% of suspicions of neonatal bacterial infection hospitalized during the study period. The female predominance was found with a sex ratio of 0.81. The most frequently isolated germs are, in order of frequency, coagulase-negative staphylococci (10 cases), Escherichia coli (7 cases), Enterobacter cloacae (5 cases), Klebsiella pneumoniae (5 cases) and Enterobacter aerogenes (5 cases). Of the 47 cases studied, 16 cases were multidrug-resistant infections including 7 cases i.e. 14.9% of nosocomial infections. The majority of Enterobacteria are strains producing broad spectrum beta lactamases (12 cases to 22). The molecules that remained effective were mainly Imipenem and Amikacin.Conclusions: Neonatal infection remains a real public health problem. The emergence of multi-resistant bacteria complicates the management. The knowledge of bacterial ecology on a wider population is an important asset in its prevention and management.

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Más fuentes

Tesis sobre el tema "Infection aerogene"

Coze, Céline. "Epidémiologie d'infections nosocomiales à enterobacter aerogènes dans un service de réanimation médicale". Bordeaux 2, 1995. http://www.theses.fr/1995BOR2P003.

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BOSI, CLAUDE. "Epidemiologie de la resistance aux antibiotiques de enterobacter aerogenes (doctorat : maladies transmissibles et pathologies tropicales)". Aix-Marseille 2, 2000. http://www.theses.fr/2000AIX20655.

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FOURIS, MARIE-ISABELLE. "Modification de la distribution des enterobacteries multiresistantes dans un service de reanimation polyvalente : recherche etiologique a partir de 52 dossiers cliniques". Clermont-Ferrand 1, 1992. http://www.theses.fr/1992CLF13057.

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Davin-Regli, Anne-Véronique. "Marquage epidemiologique par amplification aleatoire : application a l'investigation d'epidemies hospitalieres". Aix-Marseille 2, 1995. http://www.theses.fr/1995AIX20657.

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Hernández, Jessica. "Design et synthèse de nouveaux inhibiteurs de la résistance bactérienne ciblant la pompe d'efflux AcrAB-ToIC chez Enterobacter aerogenes". Thesis, Aix-Marseille, 2016. http://www.theses.fr/2016AIXM5508.

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La surexpression des pompes d’efflux (PE) appartenant à la famille Resistance-Nodulation-Division (RND) est l’un des contributeurs majeurs de la multirésistance (MDR) et la pathogénicité des bactéries Gram-négatives. Ces transporteurs sont capables d'expulser à l’extérieur de la cellule bactérienne différentes classes d'antibiotiques, ce qui contribue de manière significative à l'échec thérapeutique du traitement des maladies infectieuses. Dans ce contexte, les PEs sont des cibles intéressantes pour la découverte de nouveaux antimicrobiens. Afin de combattre ce mécanisme de résistance, des inhibiteurs des pompes d’efflux (EPIs) sont développés comme adjuvants d'antibiotiques dans le but de restaurer ou d'améliorer leur activité. L'archétype AcrAB-TolC est particulièrement répandu chez les espèces d’Enterobacter pertinentes en clinique (pathogènes « ESKAPE »). Cette étude décrit une stratégie basée sur des analogues des fluoroquinolones pour le drug design des EPIs, contre la pompe AcrB chez E. aerogenes. Ainsi, la synthèse et l'évaluation microbiologique des dérivés de quinazoline-4(3H)-one ont été effectuées. Les propriétés structurales et moléculaires des composés testés (i.e. rigidité et flexibilité) ont également été étudiées. Pour cela, de nouveaux scaffolds ont été évaluées. Plusieurs molécules ont montré une augmentation de la sensibilité des bactéries à la norfloxacine et au chloramphénicol. Les résultats obtenus, appuyés par la modélisation moléculaire, suggèrent que la flexibilité moléculaire et la nature des fonctions chimiques des EPIs jouent un rôle essentiel dans l'amélioration de l'activité et la sélectivité vis-à-vis des fluoroquinolones
Overexpression of Resistance-Nodulation-Division (RND) efflux pumps (EP) is a major contributor in multidrug resistance (MDR) and pathogenicity in Gram-negative bacteria. These transporters are able to expel out of the bacterial cell clinically important antibiotic classes, contributing in a significant manner to the treatment failure of infectious diseases. With the worrying levels of bacterial resistance reported worldwide and the continuous spreading of MDR pathogens, EPs are interesting targets for the discovery of new antimicrobial drugs. Therefore, to overcome this mechanism, efflux pump inhibitors (EPIs) are being developed as adjuvants in order to restore or improve the activity of usual antibiotics. The AcrAB-TolC archetype is particularly widespread in Enterobacter spp. presenting clinical relevance (ESKAPE pathogens). In this study, we described the drug design strategy based on fluoroquinolone antibiotic analogs, against the AcrB pump of E. aerogenes. Thus, synthesis and microbiological evaluation of quinazolin-4(3H)-one derivatives were performed. The structural and molecular properties of the tested compounds (i. e. rigidity and flexibility) were also investigated. In this purpose, a scaffold hopping of the quinazolinone core to homologous benzoquinazolinones and precursors benzamides were carried out. Several molecules increased the bacterial susceptibility towards norfloxacin and chloramphenicol. The obtained results, supported by molecular modeling, suggest that molecular flexibility and the nature of chemical functions play a critical role to improve activity and selectivity on fluoroquinolone potentiation targeting AcrB efflux pump

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Otrebska-Machaj, Ewa. "The search for new inhibitors of bacterial efflux pumps among amine derivates of 5-Arylidenehydantoin". Thesis, Aix-Marseille, 2015. http://www.theses.fr/2015AIXM5010.

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L’objet de ces recherches était de trouver de nouveaux EPIs du système d’efflux AcrAB-TolC dans les groupes de dérivés d’amine de la 5-arylidenehydantoine et de la 5-arylideneimidazolone. Dans la première étape de recherche, 32 nouveaux dérivés ont été obtenus après modification de la structure lead P2.Un screening théorique du risque toxique et la prédiction des propriétés médicamenteuses des composés ont été réalisés en utilisant le programme OSIRIS qui calcule différentes propriétés médicamenteuses pertinentes basées sur la structure planaire de la molécule.Dans l’étape suivante de la recherche, l’activité des composés a été évaluée par des études microbiologiques sur souches d’Enterobacter aerogenes avec différentes expressions de la pompe d’efflux AcrAB. La première étude effectuée était un test de sensibilité pour déterminer les CMI des composés afin de trouver une concentration à laquelle les utiliser avec des antibiotiques sans avoir l’influence de leur activité intrinsèque. Puis l’effet des composés sur la sensibilité des antibiotiques tels que l’acide nalidixique, le chloramphénicol, la doxycycline et l’érythromycine a été étudié. Après, le type de coopération avec les antibiotiques a été déterminé par la construction d’isobologrammes et le calcul de l’index de FIC. Les dernières études microbiologiques réalisées sont des tests d’efflux en temps réel qui utilisent un colorant fluorescent 1,2’-dinaphthylamine et ont permis de suivre directement le fonctionnement de la pompe. L’étude des relations structure-activité souligne le rôle essentiel de la nature amphiphile des EPIs dérivés de groupes arylidene de l’hydantoine et de l’imidazolone
The purpose of this research was to find new EPIs of the AcrAB-TolC efflux system in groups of amine derivatives of 5-arylidenehydantoin and 5-arylideneimidazolone. In the first stage of the research 32 new derivatives of 5-arylidenehydantoin were obtained as a result of modifications of the lead structure P2. Theoretical screening of the toxicity risk as well as the prediction of drug-like properties of hydantoins/imidazolones synthesised were performed by using the OSIRIS program which calculates various drug-relevant properties based on a planar structure of the molecule.In the next stage of the research the activity of compounds was evaluated in microbiological studies. Strains of Enterobacter aerogenes with different expressions of the AcrAB efflux pump were used. The first study carried out was a susceptibility test determining the MICs of compounds in order to find a concentration that could be used in combination with antibiotics without the influence of an intrinsic antibacterial activity of the compounds. Then the effect of the compounds on bacterial susceptibility to antibiotics such as nalidixic acid, chloramphenicol, doxycycline and erythromycin was examined. After, the type of cooperation with antibiotics was determined based on isobolograms and the FIC index calculated. The last of microbiological studies was the real-time efflux (RTE) assay which used the fluorescent dye 1,2’-dinaphthylamine and allowed the functioning of the pump to be monitored directly. The structure-activity relationship (SAR) analysis emphasized the essential role of the amphiphilic nature of the EPIs from the group of arylidene derivatives of hydantoin and imidazolone

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Libros sobre el tema "Infection aerogene"

An obsoure [sic] case of purpura hæmorrhagica with infection by the bacillus aerogenes capsulatus. [S.l: s.n., 1985.

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Capítulos de libros sobre el tema "Infection aerogene"

Masihi, K. N., W. Brehmer y W. Lange. "Stimulation Of Nonspecific Resistance Against Aerogenic Viral And Bacterial Infections By Muramyl Dipeptide Combined With Trehalose Dimycolate". En Biological Properties of Peptidoglycan, editado por Peter H. Seidl y Karl H. Schleifer, 401–6. Berlin, Boston: De Gruyter, 1986. http://dx.doi.org/10.1515/9783110874297-049.

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