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Tesis sobre el tema "Inhibitory synapse"

Autor: Grafiati

Publicado: 14 de diciembre de 2024

Última modificación: 31 de julio de 2025

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1

Berry, Kalen P. (Kalen Paul). "Visualizing inhibitory and excitatory synapse dynamics In vivo." Thesis, Massachusetts Institute of Technology, 2018. http://hdl.handle.net/1721.1/117876.

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Thesis: Ph. D., Massachusetts Institute of Technology, Department of Biology, June 2018.<br>Cataloged from PDF version of thesis. Page 75 blank.<br>Includes bibliographical references (pages 66-74).<br>Structural plasticity is one of the physical manifestations of circuit rewiring in the brain. Once thought to be relegated solely to developmental time periods, we now know that even in the mature brain inhibitory or excitatory connections can be made and broken, modifying the information flow within a circuit by enabling or removing specific information channels. However, the properties of inhi

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2

Sheehan, D. "Membrane dynamics of neuroligin 2 at the inhibitory synapse." Thesis, University College London (University of London), 2015. http://discovery.ucl.ac.uk/1470159/.

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Recent innovations in live-cell imaging have demonstrated that the synapse undergoes constant remodelling and reorganisation. One well characterised aspect of this process is the lateral mobility of neurotransmitter gated receptors, which enables their dynamic exchange between synaptic and extrasynaptic populations. Regulation of this process, primarily via transient receptor-scaffold interactions, determines receptor number at the synapse and thus directly shapes the strength of synaptic neurotransmission. Neuroligins (NLs) are trans-synaptic proteins that project across the synaptic cleft an

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3

Mardinly, Alan Robert. "Regulation of Synapse Development by Activity Dependent Transcription in Inhibitory Neurons." Thesis, Harvard University, 2013. http://dissertations.umi.com/gsas.harvard:10739.

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Neuronal activity and subsequent calcium influx activates a signaling cascade that causes transcription factors in the nucleus to rapidly induce an early-response program of gene expression. This early-response program is composed of transcriptional regulators that in turn induce transcription of late-response genes, which are enriched for regulators of synaptic development and plasticity that act locally at the synapse.

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4

Dietrich, Craig Julius. "Endogenous acidification of the inhibitory synapse proton amplification of GABAA-mediated neurotransmission /." Connect to Electronic Thesis (CONTENTdm), 2009. http://worldcat.org/oclc/457179973/viewonline.

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5

Dobie, Frederick Andrew. "Molecular and cellular mechanisms of inhibitory synapse formation in developing rat hippocampal neurons." Thesis, University of British Columbia, 2012. http://hdl.handle.net/2429/41933.

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The proper functioning of the brain and central nervous system (CNS) requires the precise formation of synapses between neurons. The two main neurotransmitter systems for fast synaptic communication in the CNS are excitatory glutamate and inhibitory gamma-aminobutyric acid. A growing body of evidence has begun to uncover several shared and divergent rules for the establishment of each of these two types of synapses. At the molecular level, a number of key proteins have been shown to be involved in the initial formation and subsequent development of synaptic connection, including cell adhesion

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6

Pettem, Katherine Laura. "New synaptic organizing proteins and their roles in excitatory and inhibitory synapse development." Thesis, University of British Columbia, 2012. http://hdl.handle.net/2429/42478.

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7

Merlaud, Zaha. "Nouveaux mécanismes de régulation de la synapse GABAergique inhibitrice de l’hippocampe : implication de la voie de signalisation WNK et de l’état de conformation des récepteurs GABA-A." Electronic Thesis or Diss., Sorbonne université, 2024. https://accesdistant.sorbonne-universite.fr/login?url=https://theses-intra.sorbonne-universite.fr/2024SORUS301.pdf.

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Le récepteur ionotrope de l'acide γ-aminobutyrique (GABAAR), perméable aux ions chlorures, est le principal récepteur neurotransmetteur médiateur de l'inhibition dans le cerveau des mammifères. La transmission GABAergique est soumise à une régulation complexe et multifactorielle. Non seulement façonnée par le cycle d'ouverture du GABAAR, qui dicte le passage entre ses conformations au repos, ouverte et désensibilisée, mais aussi par l'homéostasie des ions chlorure, laquelle détermine la polarité et l'efficacité de la transmission GABAergique, la transmission GABAergique repose aussi fortement

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8

Ramos, Mariana. "Unraveling the impact of IL1RAPL1 mutations on synapse formation : towards potential therapies for intellectual disability." Thesis, Sorbonne Paris Cité, 2015. http://www.theses.fr/2015PA05T036/document.

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L’intégrité des synapses neuronales est primordiale pour le développement et le maintien des capacités cognitives. Des mutations dans des gènes codant pour des protéines synaptiques ont été trouvées chez des patients atteints de déficience intellectuelle (DI), qui est une maladie neurodéveloppementale ayant des conséquences sur les fonctions intellectuelles et adaptatives. Ce travail de thèse porte sur l’étude de l’un de ces gènes, IL1RAPL1, dont les mutations sont responsables d’une forme non-syndromique de DI liée au chromosome X, et sur le rôle de la protéine IL1RAPL1 dans la formation et l

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9

Salvatico, Charlotte. "Mécanisme de diffusion-capture dans les synapses inhibitrices : suivi en molécule unique à haute densité et aspects thermodynamiques." Thesis, Paris 6, 2015. http://www.theses.fr/2015PA066736/document.

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La synapse est une structure macromoléculaire dont les composants sont renouvelés en permanence alors que l’assemblage est quasi-stable. A l’échelle mésoscopique, les récepteurs aux neurotransmetteurs (RN) sont accumulés dans le compartiment post-synaptique (PSD). Cette accumulation résulte de la diffusion latérale des RNs dans la membrane neuronale et de leurs immobilisations transitoires dans la PSD. Les protéines d’échafaudage (PE) localisées sous la membrane post-synaptique constituent des sites de capture en interagissant avec les RNs. Mon travail de thèse s’inscrit dans le cadre d’une co

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10

Mosser, Coralie-Anne. "Implication des cellules microgliales dans le développement des réseaux synaptiques du néocortex somatosensoriel Microglial BDNF promotes the functional maturation of thalamocortical synaptic networks Microglia and prenatal inflammation regulate local and horizontal wiring of inhibitory circuits." Thesis, Sorbonne Paris Cité, 2018. https://wo.app.u-paris.fr/cgi-bin/WebObjects/TheseWeb.woa/wa/show?t=2167&f=13404.

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La microglie désigne l'ensemble des macrophages résidents du système nerveux central (SNC). Longtemps considérées comme étant actives uniquement en conditions pathologiques, les cellules microgliales sont pourtant essentielles à l'activité physiologique du SNC. En particulier, pendant la formation du SNC, elles régulent apoptose et survie neuronales, et interagissent directement avec les synapses en les éliminant, en promouvant leur formation ou en régulant leur activité. Toutefois, les mécanismes microgliaux impliqués dans la mise en place et la maturation fonctionnelle des circuits corticaux

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11

Nicholson, Martin William. "Diazepam-dependent modulation of GABAergic inhibitory synapses." Thesis, University College London (University of London), 2018. http://discovery.ucl.ac.uk/10046265/.

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Diazepam is an allosteric modulator of GABAA receptors which potentiates GABAA receptor activity resulting in enhanced inhibitory synaptic transmission. Diazepam is used to treat anxiety, insomnia and seizures, however, its use is limited due to the development of tolerance. Here I show that prolonged treatment of cortical neurones with diazepam triggers endocytosis and subsequent downregulation of cell-surface GABAA receptors. Using pharmacological reagents, I have demonstrated that diazepam triggers PLC-dependent release of calcium from the endoplasmic reticulum which activates the phosphata

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12

MOSCHETTA, MATTEO. "Removal of the calcium-dependent regulation of ATP binding in Synapsin I has distinct effects at excitatory and inhibitory synapses." Doctoral thesis, Università degli studi di Genova, 2020. http://hdl.handle.net/11567/993830.

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Synapsins are the most abundant family of neuro-specific phosphoproteins associated with the cytoplasmic surface of the synaptic vesicle membrane. These proteins actively regulate synaptic transmission at the level of the presynaptic terminal by controlling the storage and mobilization of synaptic vesicles within a reserve pool. However, it is hypothesized that synapsins could be involved in other stages of synaptic vesicle dynamics such as trafficking, docking, fusion with the plasma membrane and consequent recycling. Synapsin I (SynI) in particular is expressed two isoforms (Ia and Ib) at th

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13

Villa, Katherine L. (Katherine Leigh). "Inhibitory synapses are repeatedly assembled and removed at persistent sites in vivo." Thesis, Massachusetts Institute of Technology, 2016. http://hdl.handle.net/1721.1/103167.

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Thesis: Ph. D., Massachusetts Institute of Technology, Department of Biology, 2016.<br>This electronic version was submitted by the student author. The certified thesis is available in the Institute Archives and Special Collections.<br>Cataloged from student-submitted PDF version of thesis. "February 2016."<br>Includes bibliographical references (pages 113-123).<br>Structural plasticity, the rewiring of synaptic connections, occurs not only during development, but is prevalent in the adult brain and likely represents the physical correlate of learning and memory. Removal or addition of excita

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14

Desai, Kshipra. "The role of a collybistin-kinesin complex in gephyrin trafficking to inhibitory synapses." Thesis, University College London (University of London), 2006. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.429600.

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15

He, Qionger. "Rebound potentiation : long-term potentiation of inhibitory transmission at cerebellar interneuron-Purkinje cell synapses." Thesis, University College London (University of London), 2009. http://discovery.ucl.ac.uk/17254/.

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The cerebellum is vitally important for motor learning and this behaviour is heavily reliant on the plasticity of excitatory and inhibitory synaptic transmission. Over the past two decades, numerous forms of synaptic plasticity within the cerebellum have been described, particularly affecting the principle output inhibitory neuron, the Purkinje cell (PC). In this study, I have focused on the mechanism underlying the phenomenon of rebound potentiation (RP), which is a long-lasting enhancement of inhibitory transmission at interneuron-PC synapses. RP is triggered by strong climbing fibre induced

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16

RUBEN, MASSIMO. "Coordination in space and time of excitatory and inhibitory synaptic plasticity at dendritic synapses." Doctoral thesis, Università degli studi di Genova, 2021. http://hdl.handle.net/11567/1044902.

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For years, GABAergic synapses were considered poorly plastic. However, an increasing body of evidence demonstrated that, similarly to excitatory synapses, inhibitory synapses formed by interneurons onto pyramidal cells can be modulated in response to neuronal activity. The spiking output of a neuron is determined by the opposite but concomitant action of excitation and inhibition. In this view, it is crucial to understand how plasticity at excitatory and inhibitory synapses is coordinated. In this thesis, I will describe two different types of plasticity interplay between excitation and inhibi

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17

Camiré, Olivier, and Olivier Camiré. "Ca²+ mechanisms of synaptic integration and plasticity in inhibitory interneurons." Doctoral thesis, Université Laval, 2019. http://hdl.handle.net/20.500.11794/37039.

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Tableau d'honneur de la FÉSP<br>Tableau d'honneur de la FÉSP<br>La signalisation calcique dendritique joue un rôle important dans la régulation de mécanismes neuronaux, tels que la plasticité synaptique et l’intégration de l’information transmise. Bien compris chez les neurones principaux, ce processus de régulation est moins étudié chez les divers types d’interneurones GABAergiques qui modulent l’acquisition et l’envoi de signaux neuronaux. Chez les interneurones à décharge rapide, un type d’interneurone commun dans les circuits corticaux, il a été démontré qu’il y a absence de rétropropagati

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18

Nasrallah, Kaoutsar. "Consequences of synaptic plasticity at inhibitory synapses in mouse hippocampal area CA2 under normal and pathological conditions." Thesis, Sorbonne Paris Cité, 2015. http://www.theses.fr/2015USPCB089/document.

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L'hippocampe est une région du cerveau importante pour la formation de mémoire. Des études récentes ont montré que la zone CA2 de l'hippocampe, longtemps ignorée, joue un rôle clef dans certaines formes de mémoire et notamment dans la mémoire sociale. De plus, des études post-mortem ont révélé des altérations spécifiques à la région CA2 chez les patients schizophrènes. Cependant, l’implication des neurones de CA2 dans les circuits de l'hippocampe reste peu connu, tant dans des conditions physiologiques que pathologiques. En combinant pharmacologie, génétique et électrophysiologie sur tranches

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19

Klomjai, Wanalee. "Modifications d'excitabilité des réseaux neuronaux de la moelle épinière chez des sujets sains et des patients porteurs de lésions du système nerveux central." Thesis, Paris 6, 2014. http://www.theses.fr/2014PA066165/document.

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Ma thèse est consacrée à l’étude des réseaux neuronaux spinaux impliqués dans la motricité chez l’Homme est comprend deux chapitres. Des travaux récents effectués sur la moelle épinière du rat ont mis en évidence qu’au cours du développement chez les mammifères, les synapses GABAergiques et glycinergiques sont tout d’abord excitatrices avant de devenir inhibitrices et qu’une section de la moelle épinière ne permet pas cette transformation. Cette transition développementale semble due à l’action d’un transporteur transmembranaire (KCC2) au cours de développement qui diminue après section de la

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20

Vecchia, Dania. "EXCITATORY AND INHIBITORY SYNAPTIC TRANSMISSION AT CORTICAL SYNAPSES IN CaV2.1 KNOCK-IN MICE CARRYING FAMILIAL HEMIPLEGIC MIGRAINE MUTATIONS." Doctoral thesis, Università degli studi di Padova, 2010. http://hdl.handle.net/11577/3427028.

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Missense mutations in the human CACNA1A gene, which encodes the pore-forming a1 subunit of the CaV2.1 (P/Q-type) Ca2+ channel, cause familial hemiplegic migraine type 1 (FHM1), a rare subtype of migraine with aura (Ophoff et al., 1996). Apart from the characteristic hemiparesis, the headache, autonomic and aura symptoms of typical attacks of FHM1 are similar to those of the common forms of migraine with aura (Pietrobon, 2007; Pietrobon and Striessnig, 2003). CaV2.1 channels are located in presynaptic terminals and somatodendritic membranes throughout the brain, where they play a dominant role

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21

Pereira, Alyssa. "Rôle de la Cadhérine-13 dans le développement des synapses des cellules de Golgi." Thesis, Université de Montpellier (2022-….), 2022. http://www.theses.fr/2022UMONT012.

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Différentes études ont montré que des altérations du gène codant pour la Cadhérine-13 (CDH13) sont impliquées dans de nombreux troubles neurologiques (autisme (TSA), troubles de déficit de l’attention avec ou sans hyperactivité, déficiences intellectuelles, maladies psychiatriques). La CDH13 est un membre atypique de la superfamille des cadhérines, car elle est dépourvue de domaine transmembranaire et intracellulaire et, contrairement aux autres cadhérines, elle est fixée à la membrane par une ancre glycosylphosphatidylinositol (GPI). Il a été démontré que la CDH13 joue un r

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22

Schäfer, Jonas K. "Preparation and investigation of an in vitro model system for the GABAA receptor organisation machinery of inhibitory post synapses." Doctoral thesis, Niedersächsische Staats- und Universitätsbibliothek Göttingen, 2020. http://hdl.handle.net/21.11130/00-1735-0000-0005-1426-A.

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23

Huang, Yung-Chi. "Behavioral and Functional Analysis of a Calcium Channelopathy in Caenorhaditis elegans." eScholarship@UMMS, 2017. https://escholarship.umassmed.edu/gsbs_diss/893.

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The brain network is a multiscale hierarchical organization from neurons and local circuits to macroscopic brain areas. The precise synaptic transmission at each synapse is therefore crucial for neural communication and the generation of orchestrated behaviors. Activation of presynaptic voltage-gated calcium channels (CaV2) initiates synaptic vesicle release and plays a key role in neurotransmission. In this dissertation, I have aimed to uncover how CaV2 activity affects synaptic transmission, circuit function and behavioral outcomes using Caenorhabditis elegans as a model. The C. elegans geno

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24

Huang, Yung-Chi. "Behavioral and Functional Analysis of a Calcium Channelopathy in Caenorhaditis elegans." eScholarship@UMMS, 2004. http://escholarship.umassmed.edu/gsbs_diss/893.

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The brain network is a multiscale hierarchical organization from neurons and local circuits to macroscopic brain areas. The precise synaptic transmission at each synapse is therefore crucial for neural communication and the generation of orchestrated behaviors. Activation of presynaptic voltage-gated calcium channels (CaV2) initiates synaptic vesicle release and plays a key role in neurotransmission. In this dissertation, I have aimed to uncover how CaV2 activity affects synaptic transmission, circuit function and behavioral outcomes using Caenorhabditis elegans as a model. The C. elegans geno

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25

Bautista, Melissa A. "Ultrastructural Analysis of Excitatory and Inhibitory Synapses within the Medial Nucleus of the Trapezoid Body of Normal Hearing and Congenitally Deaf Mice." Wright State University / OhioLINK, 2008. http://rave.ohiolink.edu/etdc/view?acc_num=wright1229722450.

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26

Schäfer, Jonas K. [Verfasser]. "Preparation and investigation of an in vitro model system for the GABAA receptor organisation machinery of inhibitory post synapses / Jonas K. Schäfer." Göttingen : Niedersächsische Staats- und Universitätsbibliothek Göttingen, 2020. http://d-nb.info/1236401492/34.

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27

Mayer, Simone Verfasser], Nils [Akademischer Betreuer] Brose, Reinhard [Akademischer Betreuer] Jahn, et al. "Molecular mechanisms of collybistin-dependent gephyrin clustering at inhibitory synapses / Simone Mayer. Gutachter: Reinhard Jahn ; Blanche Schwappach ; Tobias Moser ; Oliver Schlüter ; Dieter Klopfenstein. Betreuer: Nils Brose." Göttingen : Niedersächsische Staats- und Universitätsbibliothek Göttingen, 2014. http://d-nb.info/1053119356/34.

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28

Lilly, Scott Matthew. "Protein Kinase A Alterations Following Chronic Flurazepam Treatment: Implications for Inhibitory and Excitatory Synaptic Plasticity in Rat Hippocampal CA1." Connect to full-text via OhioLINK ETD Center, 2006. http://rave.ohiolink.edu/etdc/view?acc%5Fnum=mco1145293063.

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Thesis (Ph.D.)--Medical University of Ohio, 2006.<br>"In partial fulfillment of the requirements for the degree of Doctor of Philosophy in Medical Sciences." Major advisor: Elizabeth I. Tietz. Includes abstract. Document formatted into pages: iv, 234 p. Title from title page of PDF document. Bibliography: pages 86-95,126-135,167-174,190-232.

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29

Yang, Xiaojuan. "Microscopie super-résolutive aux synapses inhibitrices mixtes : régulation différentielle des GlyRs et des GABAARs par l’activité excitatrice." Thesis, Paris Sciences et Lettres (ComUE), 2019. http://www.theses.fr/2019PSLEE012/document.

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La microscopie optique stochastique de reconstruction (STORM) contourne la limite de diffraction en enregistrant des signaux monomoléculaires spatialement et temporellement séparés, atteignant une résolution de ~10-40 nm. Dans mon étude, j'ai développé une stratégie d'imagerie et d'analyse de données dSTORM bicolore afin d'étudier l'ultrastructure des synapses inhibitrices mixtes. Mes résultats ont montré que les GlyRs, les GABAARs, la géphyrine et RIM1/2 présentent une organisation intra-synaptique hétérogène et forment des domaines sous-synaptiques (SSDs). Les GlyR et les GABAAR ne sont pas

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30

Leonardon, Benjamin. "Modulation de la transmission synaptique inhibitrice par les récepteurs NMDA dans la corne dorsale de la moelle épinière de souris." Thesis, Strasbourg, 2020. http://www.theses.fr/2020STRAJ006.

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Dans les cornes dorsales (CD), la transmission synaptique inhibitrice joue un rôle clef dans le traitement des informations nociceptives. Cette inhibition peut subir des changements plastiques menant à des symptômes d’hyperalgésie et d’allodynie liés aux douleurs neuropathiques. Dans les CD, les récepteurs NMDA sont recrutés suite à une lésion nerveuse, bien que leur rôle dans les phénomènes de plasticités de la synapse excitatrice soit bien étudié, leur implication dans la plasticité de l’inhibition spinale reste peu connue. Mon projet de thèse a visé à déterminer l’effet de l’activation des

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31

Santos, Inês Baião. "ARHGAP8 co-regulates excitatory and inhibitory synapse function." Master's thesis, 2017. http://hdl.handle.net/10316/83148.

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Dissertação de Mestrado em Biologia Celular e Molecular apresentada à Faculdade de Ciências e Tecnologia<br>A remodelação das estruturas sinápticas, dependente do tipo de estímulos que recebem, é o mecanismo molecular responsável pela plasticidade dos circuitos neuronais – um processo que se julga estar na base da aprendizagem e da memória. O processamento de informação e a plasticidade dos circuitos no sistema nervoso central dependem do equilíbrio entre a função excitatória e a função inibitória. O estabelecimento de uma correta transmissão glutamatérgica (excitatória) e GABAérgica (inibitór

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32

Hoon, Mrinalini. "Role of Neuroligins at the Inhibitory Postsynaptic Compartment of the Retina." Doctoral thesis, 2010. http://hdl.handle.net/11858/00-1735-0000-0006-B512-1.

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Poulopoulos, Alexandros. "Mechanisms of Neuroligin Function in Inhibitory Postsynaptic Differentiation." Doctoral thesis, 2008. http://hdl.handle.net/11858/00-1735-0000-0006-B502-5.

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Soykan, Tolga. "Neuroligin 2 Induced Allosteric Transition of Collybistin Underlies Inhibitory Postsynaptic Differentiation." Doctoral thesis, 2011. http://hdl.handle.net/11858/00-1735-0000-000D-F0AD-9.

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35

Mayer, Simone. "Molecular mechanisms of collybistin-dependent gephyrin clustering at inhibitory synapses." Doctoral thesis, 2014. http://hdl.handle.net/11858/00-1735-0000-0022-5F06-C.

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36

Hoang, Phuong Thi. "Subtype diversification and synaptic specificity of stem cell-derived spinal inhibitory interneurons." Thesis, 2017. https://doi.org/10.7916/D8Z89J66.

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During nervous system development, thousands of distinct neuronal cell types are generated and assembled into highly precise circuits. The proper wiring of these circuits requires that developing neurons recognize their appropriate synaptic partners. Analysis of a vertebrate spinal circuit that controls motor behavior reveals distinct synaptic connections of two types of inhibitory interneurons, a ventral V1 class that synapses with motor neurons and a dorsal dI4 class that selectively synapses with proprioceptive sensory neuron terminals that are located on or in close proximity to motor neur

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37

Fang, Cheng. "Structural and functional modulation of inhibitory synapses by GODZ-mediated palmitoylation of GABAA receptors." 2007. http://www.etda.libraries.psu.edu/theses/approved/WorldWideIndex/ETD-1888/index.html.

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Ormond, John. "Disinhibition at Feedforward Inhibitory Synapses in Hippocampal Area CA1 Induces a Form of Long-term Potentiation." Thesis, 2009. http://hdl.handle.net/1807/24326.

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One of the central questions of neuroscience research has been how the cellular and molecular components of the brain give rise to complex behaviours. Three major breakthroughs from the past sixty years have made the study of learning and memory central to our understanding of how the brain works. First, the psychologist Donald Hebb proposed that information storage in the brain could occur through the strengthening of the connections between neurons if the strengthening were restricted to neurons that were co-active (Hebb, 1949). Second, Milner and Scoville (1957) showed that the hippocampus

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Hardie, Jason B. "Shaping of inhibitory fuction : interactions of cellular properties with [Gamma]-aminobutyric acid type A synapses in CA1 of the hippocampus /." 2005. http://catalog.hathitrust.org/api/volumes/oclc/70853476.html.

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40

Whitebirch, Alexander Craig. "Inhibitory-excitatory imbalance in hippocampal subfield cornu ammonis 2 circuitry in a mouse model of temporal lobe epilepsy." Thesis, 2021. https://doi.org/10.7916/d8-289z-fj47.

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Temporal lobe epilepsy (TLE) is among the most common forms of epilepsy in adults. A significant proportion of patients experience drug-resistant seizures associated with hippocampal sclerosis (HS), in which there is extensive cell loss in the hippocampal cornu ammonis 1 (CA1) and cornu ammonis 3 (CA3) subfields. The dentate gyrus (DG) and cornu ammonis 2 (CA2) subfield are more resilient to neurodegeneration, and a prior report found that CA2 neurons in tissue from TLE patients show interictal-like firing and receive aberrant perisomatic excitatory synapses from DG granule cell (GC) mossy fi

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41

Nasar, Rakin Tammam. "Comparisons of calretinin and parvalbumin neuronal distribution, density and inhibitory synapses in rhesus monkey prefrontal cortex and primary visual cortex and the analogous areas of mice." Thesis, 2020. https://hdl.handle.net/2144/41318.

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Calretinin (CR) and parvalbumin (PV) neurons are inhibitory interneurons (INs) that play important roles in the modulation of excitatory pyramidal neurons. They are found in many species are and throughout the neocortex. However, their characteristics vary between species and brain region. The aim of this study was to compare the density, distribution, and inhibitory signaling of CR and PV neurons in monkey primary visual cortex (V1), monkey lateral prefrontal cortex (LPFC), mouse V1 and mouse frontal cortex (FC). Coronal brain slices from each of the species and brain regions were stained usi

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Corrêa, Sonia A. L., C. J. Hunter, O. Palygin, et al. "MSK1 regulates homeostatic and experience-dependent synaptic plasticity." 2012. http://hdl.handle.net/10454/5942.

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No<br>The ability of neurons to modulate synaptic strength underpins synaptic plasticity, learning and memory, and adaptation to sensory experience. Despite the importance of synaptic adaptation in directing, reinforcing, and revising the behavioral response to environmental influences, the cellular and molecular mechanisms underlying synaptic adaptation are far from clear. Brain-derived neurotrophic factor (BDNF) is a prime initiator of structural and functional synaptic adaptation. However, the signaling cascade activated by BDNF to initiate these adaptive changes has not been elucidated. We

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