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Artículos de revistas sobre el tema "Interleukine-6 [IL-6]"

Autor: Grafiati

Publicado: 4 de junio de 2021

Última modificación: 1 de febrero de 2022

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1

Gaillard, O. "Interleukine 6 (IL-6)." Immuno-analyse & Biologie Spécialisée 17, no. 3 (2002): 140–42. http://dx.doi.org/10.1016/s0923-2532(02)01191-2.

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Abdel-Fattah, M., K. El Gaaly, M. Al-Refai, and D. Galwash. "ESTIMATION OF SALIVARY LEVELS OF INTERLEUKINE-6 (IL-6) AND INTERLEUKINE-8 (IL-8) IN THE ORAL PRE-MALIGNANT AND MALIGNANT LESIONS." Egyptian Dental Journal 62, no. 1 (2016): 193–201. http://dx.doi.org/10.21608/edj.2016.92655.

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3

Gorham, Julie, Anthony Moreau, Francis Corazza, et al. "Interleukine-6 in critically ill COVID-19 patients: A retrospective analysis." PLOS ONE 15, no. 12 (2020): e0244628. http://dx.doi.org/10.1371/journal.pone.0244628.

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Introduction Coronavirus disease 2019 (COVID-19) appeared in China in December 2019 and has spread around the world. High Interleukin-6 (IL-6) levels in COVID-19 patients suggest that a cytokine storm may play a major role in the pathophysiology and are considered as a relevant parameter in predicting most severe course of disease. The aim of this study was to assess repeated IL-6 levels in critically ill COVID-19 patients admitted to our Intensive Care Unit (ICU) and to evaluate their relationship with patient’s severity and outcome. Methods We conducted a retrospective study on patients admi

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4

Kostik, M., M. Makhova, D. Kozlova та ін. "FRI0374 PLASMA LEVELS OF 14-3-3 PROTEIN, S100A8/S100A9-PROTEIN, INTERLEUKIN-6, INTERLEUKIN-18, INTERLEUKIN-4, INTERLEUKIN-17, INTERLEUKIN-1Β AND TUMOR NECROSIS FACTOR-Α IN CHRONIC NON-BACTERIAL OSTEOMYEILITIS AND NON-SYSTEMIC JUVENILE IDIOPATHIC ARTHRITIS". Annals of the Rheumatic Diseases 79, Suppl 1 (2020): 784.3–784. http://dx.doi.org/10.1136/annrheumdis-2020-eular.6469.

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Background:Chronic non-bacterial osteomyelitis (CNO) is an immune-mediated disease associated with cytokine dysbalance.Objectives:The aim of our study was to evaluate the cytokines levels in CNO and compare to juvenile idiopathic arthritis (JIA) – disease with immune-mediated mechanism.Methods:The diagnosis of CNO made with criteria, proposed by Jansson (2007, 2009), after the exclusion of other causes of bone disease [1]. We included 42 patients with NBO, 28 patients with non-systemic juvenile idiopathic arthritis (JIA). We evaluated plasma levels of 14-3-3 protein, S100A8/S100A9-protein, int

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Sassano, Pierpaolo, Francesco Paparo, Valerio Ramieri, Walter Colangeli, and Giuseppe Verdino. "Interleukine-6 (IL-6) may be a link between myasthenia gravis and myoepithelioma of the parotid gland." Medical Hypotheses 68, no. 2 (2007): 314–17. http://dx.doi.org/10.1016/j.mehy.2006.06.057.

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R. Sarhat, Entedhar, Zubaidah N. M Albarzanji, and Chateen I. Ali Pambuk. "Estimation of Some Interleukins in Cerebrospinal Fluid in Children with Meningitis." Biomedical and Pharmacology Journal 12, no. 04 (2019): 2151–55. http://dx.doi.org/10.13005/bpj/1850.

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Meningitis is often associated with cerebral compromise which may be responsible for neurological squeal in nearly half of the survivors. Little is known about the mechanisms of CNS involvement in bacterial meningitis. the current study was to analyze the clinical significance of cerebrospinal fluid (CSF) concentrations of interleukin (IL)- 6, IL-1, IL-8, IL-10, tumor necrosis factor-alpha (TNF-α), and C-reactive protein in children with meningitis (n=35) and compared with control subjects (n=28). Serum total protein, interleukine-6, IL-1 , IL-8, IL-10 , and, CRP, and TNF-α levels were found t

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Pierer, M., U. Wagner, and S. Unger. "Zytokinblockade zur Behandlung rheumatologischer Erkrankungen." Arthritis und Rheuma 29, no. 04 (2009): 241–42. http://dx.doi.org/10.1055/s-0037-1620175.

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ZusammenfassungDie Interleukine IL-1 und IL-6 sind von elementarer pathogenetischer Bedeutung bei der Entstehung der rheumatoiden Arthritis und damit Angriffspunkte für die Entwicklung neuer Behandlungsstrategien. Die Interleukin-Rezeptor-Antagonisten Anakinra und Tocilizumab dienen neben bzw. bei Versagen der anderen Biologika als Therapieoption mit dem Ziel einer anhaltenden Remission und Verhinderung einer Gelenkdestruktion. Aktu-ell wird in Studien der Einsatz auch bei weiteren entzündlich-rheumatologischen Erkrankungen erprobt. Nach präziser Indikationsstellung, Ausschluss von Kontraindik

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8

Gantsev, Shamil Kh, and R. R. Bakiyev. "Local tissue interleukine profile in breast cancer." Russian Journal of Oncology 21, no. 1-2 (2016): 60–65. http://dx.doi.org/10.18821/1028-9984-2015-21-1-60-65.

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Breast cancer ranks first in the structure of oncological diseases in women in Russia and in the World. In recent years there have been numerous reports that the growth and progression of breast cancer and other tumors depend not only on their malignant potential, but also on stromal factors presented in the tumor microenvironment and intercellular interactions. The aim of our study was to evaluate intercellular interactions of the tissues surrounding the tumor, by means of determination of the locally interleukine profile. We have identified interleukine profiles of the axillary fatty tissue

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9

Morieri, Mario Luca, Angelina Passaro, and Giovanni Zuliani. "Interleukin-6 “Trans-Signaling” and Ischemic Vascular Disease: The Important Role of Soluble gp130." Mediators of Inflammation 2017 (2017): 1–6. http://dx.doi.org/10.1155/2017/1396398.

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Inflammation plays a major role in the onset of cardiovascular disease (CVD). Interleukine-6 (IL-6) is a multifunctional cytokine involved both in the beneficial acute inflammatory response and in the detrimental chronic low-grade systemic inflammation. Large genetic human studies, using Mendelian randomization approaches, have clearly showed that IL-6 pathway is causally involved in the onset of myocardial infarction. At the same time, IL-6 pathway is divided into two arms: classic signaling (effective in hepatocytes and leukocytes) and trans-signaling (with ubiquitous activity). Trans-signal

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Pieteris, Linas, Giedrė Bakšytė, Tadas Česnaitis, Astra Vitkauskienė, and Andrius Macas. "New strategies in sepsis diagnosis." Acta medica Lituanica 19, no. 3 (2012): 160–62. http://dx.doi.org/10.6001/actamedica.v19i3.2440.

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Successful treatment of sepsis begins from early diagnosis and prognosis. In last decades the number of sepsis cases is growing, so establishing early diagnosis of sepsis as well as effectiveness of treatment are very significant. That is why development of new diagnostic sepsis markers is important. In this review we evaluated a new sepsis marker Presepsin (sCD14) and compared it to other markers: Procalcitonin (PCT), C-reactive protein (CRP) and Interleukine-6 (IL-6).

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11

Manček-Keber, Mateja, Rosana Ribić, Fernando Chain, et al. "Adamantane Containing Peptidoglycan Fragments Enhance RANTES and IL-6 Production in Lipopolysaccharide-Induced Macrophages." Molecules 25, no. 16 (2020): 3707. http://dx.doi.org/10.3390/molecules25163707.

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We report the enhancement of the lipopolysaccharide-induced immune response by adamantane containing peptidoglycan fragments in vitro. The immune stimulation was detected by Il-6 (interleukine 6) and RANTES (regulated on activation, normal T cell expressed and secreted) chemokine expression using cell assays on immortalized mouse bone-marrow derived macrophages. The most active compound was a α-D-mannosyl derivative of an adamantylated tripeptide with L-chirality at the adamantyl group attachment, whereby the mannose moiety assumed to target mannose receptors expressed on macrophage cell surfa

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12

Tjiong, H. L., F. J. Zijlstra, T. Rietveld, et al. "Peritoneal Protein Losses and Cytokine Generation in Automated Peritoneal Dialysis with Combined Amino Acids and Glucose Solutions." Mediators of Inflammation 2007 (2007): 1–5. http://dx.doi.org/10.1155/2007/97272.

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Objectives. Protein-energy malnutrition as a consequence of deficient protein intake frequently occurs in peritoneal dialysis (PD) patients. Previously, we showed that peritoneal dialysate containing a mixture of amino acids (AA) and glucose has anabolic effects. However AA-dialysate has been reported to increase intraperitoneal protein and AA losses and the release of proinflammatory cytokines (interleukine-6 (IL-6) and tumor necrosis factor alpha (TNFα)). We investigated the effect of AA plus glucose (AAG) solutions on peritoneal protein losses and cytokine generation.Methods. In 6 patients

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Salih, Zahraa, Jawnaa Mammdoh та Amer Taqa. "Evaluate the Anti-inflammatory Effects of Nanocinnamon Gel on Salivary Cytokines: Tumor Necrosis factor-alpha (TNF-α) and Interleukine-6 (IL-6) in Chronic Gingivitis". Al-Rafidain Dental Journal 21, № 1 (2021): 62–74. http://dx.doi.org/10.33899/rden.2020.127851.1047.

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Oger, Emmanuel, Grégoire Le Gal, Marie-Thérèse Blouch, et al. "Differential effects of oral and transdermal postmenopausal estrogen replacement therapies on C-reactive protein." Thrombosis and Haemostasis 90, no. 07 (2003): 124–31. http://dx.doi.org/10.1055/s-0037-1613608.

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SummaryC-reactive protein (CRP) is one of the main independent predictors of cardiovascular events. Oral post-menopausal estro-gen replacement therapy (ERT) increases CRP levels, but the effect of transdermal ERT is not well documented.CRP, interleukine-6 (IL-6) and tumor necrosis factor-α (TNF-α) levels were evaluated in a randomised study of 196 healthy postmenopausal women, who were allocated to receive continuous oral estradiol-17β, (n=63) or transdermal estradiol-17β, (n=68) both combined with micronised progesterone, or placebo (n=65). Oral estrogen increased CRP levels compared with bot

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Saad, Bashar, Bernadette Soudah AbouAtta, Walid Basha та ін. "Hypericum triquetrifolium—Derived Factors Downregulate the Production Levels of LPS-Induced Nitric Oxide and Tumor Necrosis Factor-αin THP-1 Cells". Evidence-Based Complementary and Alternative Medicine 2011 (2011): 1–7. http://dx.doi.org/10.1093/ecam/nen056.

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Based on knowledge from traditional Arab herbal medicine, thisin vitrostudy aims to examine the anti-inflammatory mechanism ofHypericum triquetrifoliumby measuring the expression and release of pro-inflammatory cytokines, tumor necrosis factor-α(TNF-α) and interleukine-6 (IL-6), and inducible nitric oxide synthase (iNOS) in human monocytic cells, THP-1. The effects were assessed by measuring the levels of secretory proteins and mRNA of TNF-αand IL-6, the levels of nitric oxide (NO) secretion and the expression of iNOS in THP-1 cells. Cells were treated with 5 μg lipopolysaccharide/ml (LPS) in

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KARABULUT, TUĞBA SEVAL FATMA TOYDEMIR, and KIVILCIM SÖNMEZ. "Evaluation of tissue trauma and healing on the basis of tumour necrosis factor-alpha, interleukin-6, and C-reactive protein in peripheral blood during and after pyometra in bitches." Medycyna Weterynaryjna 74, no. 10 (2018): 658–64. http://dx.doi.org/10.21521/mw.6122.

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In this study, inflammation in the blood of bitches with pyometra (PG) was compared before and 15 days after ovariohysterectomy (OVH). The results were compared with those for control dioestrus bitches (CG) to reveal the evidence of inflammation in blood after a routine surgery. Inflammation was tracked by tumour necrosis factor-alpha (TNF-α), interleukine-6 (IL-6) and C-reactive protein (CRP), using immunocytochemistry (ICC) and immunofluorescence capture of blood cells in cell blocks. ICC is performed mainly during routine cytological examinations, whereas the use of cell blocks in blood exa

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17

Aganovic-Musinovic, Izeta, Nesina Avdagic, Nermina Babic, et al. "Immunoglobulin free light chains and interleukin-6 levels in prediction of kidney injury in patients with multiple myeloma." Asian Journal of Medical Sciences 10, no. 2 (2019): 1–7. http://dx.doi.org/10.3126/ajms.v10i2.21977.

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Background: Multiple myeloma (MM) is a disease of B cell population with excessive secretion of immunoglobulins and presence of free light chains (FLCs) that are by products of immunoglobulin synthesis. Free light chains play crucial role in causing renal damage. Interleukine-6 (IL-6) supports the survival and/or expansion of MM cells by stimulating cells as well as by preventing programmed cell death. Aims and Objectives: The aim of this study was to evaluate serum and urine free light chains (FLC)measurement and compare with IL-6 levels in patients with different stages of Multiple Mye

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Haj-allahyari, Samaneh, and Dr Maghsoudi, Hossein. "Suppression of Proinflamatroy cytokine gene expression with Aqueous Extract of Berberin." International Journal of Contemporary Research and Review 9, no. 03 (2018): 20224–38. http://dx.doi.org/10.15520/ijcrr/2018/9/03/481.

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Based on knowledge from traditional Iranian herbal medicine, this ex vitro study aims to examine the anti-inflammatory mechanism of Berberis vulgaris L by measuring the expression and release of pro-inflammatory cytokines, tumor necrosis factor-α (TNF-α), cyclooxygenase-1 (COX-1), and interleukine-18 (IL-6), IL-1β and inducible nitric oxide synthase (iNOS) in THP-1. The effects were assessed by measuring the levels of secretory proteins and mRNA of TNF-α and IL-6, the levels of nitric oxide (NO) secretion and the expression of iNOS in THP-1 cells. Cells were treated with 20 ng lipopolysacchari

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19

Lee, Yujin, Joo Weon Lim та Hyeyoung Kim. "α-Lipoic Acid Inhibits IL-6 Expression by Upregulating PPAR-γ-Mediated Expression of Antioxidants in Cerulein/Resistin-Stimulated Pancreatic Acinar Cells". Current Developments in Nutrition 5, Supplement_2 (2021): 1133. http://dx.doi.org/10.1093/cdn/nzab061_017.

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Abstract Objectives Oxidative stress is regarded as a major pathogenic factor in acute pancreatitis. Obesity is thought to be a negative prognostic factor in acute pancreatitis. Levels of serum resistin, an adipocytokine secreted by fat tissues, increase with obesity. Recent study showed that resistin aggravates the expression of inflammatory cytokines such as interleukine-6 (IL-6) and production of reactive oxygen species (ROS) in pancreatic acinar cells stimulated with cerulein, a cholecystokinin analogue, as an in vitro acute pancreatitis model. Peroxisome proliferator-activated receptor (P

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20

Seliger, Gregor, Michael Bergner, Roland Haase, et al. "Daily monitoring of vaginal interleukin 6 as a predictor of intraamniotic inflammation after preterm premature rupture of membranes – a new method of sampling studied in a prospective multicenter trial." Journal of Perinatal Medicine 49, no. 5 (2021): 572–82. http://dx.doi.org/10.1515/jpm-2020-0406.

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Abstract Objectives (A) To introduce a new technique for vaginal fluid sampling (biocompatible synthetic fiber sponge) and (B) evaluate the collected vaginal fluid interleukine-6 (IL-6vag)-concentration as a new diagnostic tool for daily monitoring of intrauterine inflammation after preterm premature rupture of membranes (PPROM). Secondary objectives were to compare the potential to predict an intrauterine inflammation with established inflammation parameters (e.g., maternal white blood cell count). Methods This prospective clinical case-control diagnostic accuracy multicenter study was perfor

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Lychko, V. S. "MODERN TREATMENT METHODS OF THE LOCALIZED INFLAMMATORY RESPONSE IN ACUTE CEREBRAL ISCHEMIA." Eastern Ukrainian Medical Journal 8, no. 1 (2020): 8–14. http://dx.doi.org/10.21272/eumj.2020;8(1):8-14.

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The article shows the results of a complex study of the leading index changes of the cytokine profile in patients with the brain infarction (BI) in the course of therapy with human cryopreserved cord blood serum (CCBS). Plasma levels of proinflammatory cytokines (interleukine-6 (IL-6), tumor necrosis factor-α (TNF-α)) as well as anti-inflammatory factors – IL-4, IL‑10 were tested in the blood serum of 350 patients in the mentioned medical condition on the 1st, 10th and 21st days of therapy. All patients were divided into 2 groups: the 1st one (n = 175) got undifferentiated therapy with the add

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Kurtdede, Efe, Gizem Aralan, Remzi Soner Cengiz, Ayten Aşkın Kilinç, Çağlar Coşkun, and Berrin Salmanoğlu. "Evaluation of Systemic Inflammation Parameters in Dogs with Periodontitis." Acta Veterinaria 69, no. 2 (2019): 218–28. http://dx.doi.org/10.2478/acve-2019-0017.

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Abstract Periodontal diseases are the most common diseases in veterinary medicine. The first clinical finding is chewing difficulty, saliva flow and bad oral odor. It further develops into plaque and tartar formation, gingival inflammation and hemorrhagic appearance of the gingiva, periodontal pockets formation, alveolar bone resorption and tooth loss. In this study an evaluation has been made to determine which degree reflects on the parameters of systemic inflammatory reaction with special attention to IL-6 (Interleukine-6), CRP (C-reactive protein), osteopontin, superoxide dismutase (SOD),

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23

Zou, Yuan-Feng, Yan-Yun Zhang, Yu-Ping Fu, et al. "A Polysaccharide Isolated from Codonopsis pilosula with Immunomodulation Effects Both In Vitro and In Vivo." Molecules 24, no. 20 (2019): 3632. http://dx.doi.org/10.3390/molecules24203632.

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In this study, an acidic polysaccharide from Codonopsis pilosula Nannf. var. modesta (Nannf.) L. T. Shen (WCP-I) and its main fragment, WCP-Ia, obtained after pectinase digestion, were structurally elucidated and found to consist of a rhamnogalacturonan I (RG-I) region containing both arabinogalactan type I (AG-I) and type II (AG-II) as sidechains. They both expressed immunomodulating activity against Peyer’s patch cells. Endo-1,4-β-galactanase degradation gave a decrease of interleukine 6 (IL-6) production compared with native WCP-I and WCP-Ia, but exo-α-l-arabinofuranosidase digestion showed

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24

Aloysius, Thomas, Ana Carvajal, Rasa Slizyte, Jon Skorve, Rolf Berge, and Bodil Bjørndal. "Chicken Protein Hydrolysates Have Anti-Inflammatory Effects on High-Fat Diet Induced Obesity in Mice." Medicines 6, no. 1 (2018): 5. http://dx.doi.org/10.3390/medicines6010005.

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Background: Studies have shown that dietary source of protein and peptides can affect energy metabolism and influence obesity-associated diseases. This study aimed to investigate the impact of different chicken protein hydrolysates (CPHs) generated from chicken rest raw materials in a mouse obesity model. Methods: Male C57BL/6 mice were fed a high-fat, high-sucrose diet with casein or CPHs generated using Papain + Bromelain, Alcalase, Corolase PP, or Protamex for 12 weeks (n = 12). Body weight, feed intake, and intraperitoneal glucose tolerance was determined, and plasma and liver and adipose

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25

Matsuda, Tadashi, and Toshio Hirano. "Interleukin 6 (IL-6)." Biotherapy 2, no. 4 (1990): 363–73. http://dx.doi.org/10.1007/bf02170085.

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Bauvois, Adeline, Mélusine Larivière, Hervé Watier, and François Maillot. "Actualités des anticorps monoclonaux dans les maladies monogéniques aujourd’hui." médecine/sciences 35, no. 12 (2019): 1026–28. http://dx.doi.org/10.1051/medsci/2019203.

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Les maladies monogéniques sont des maladies génétiques rares mais très nombreuses, avec une sévérité variable. Les premières utilisations des anticorps monoclonaux dans ces maladies remontent aux années 2000 et de nombreux essais sont désormais en cours. Les anticorps monoclonaux anti-(interleukine)IL-1β ont profondément transformé la prise en charge des maladies auto-inflammatoires en modulant la composante inflammatoire et en diminuant le risque d’amylose secondaire ; les anticorps monoclonaux anti-TNF-α et anti-IL-6 sont également prescrits dans ces maladies. Dans le syndrome hémolytique et

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Sitaru, Ana-Gabriela, Christian P. Speer, Susanne Holzhauer, Achim Obergfell, Ulrich Walter, and Ralf Grossmann. "Chorioamnionitis is associated with increased CD40L expression on cord blood platelets." Thrombosis and Haemostasis 94, no. 12 (2005): 1219–23. http://dx.doi.org/10.1160/th05-02-0127.

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SummaryChorioamnionitis (CA) is a severe infection responsible not only for premature birth but also for many severe neonatal diseases. The aim of the present study was to investigate the expression of CD40L and P-selectin on platelets and the plasma levels of their soluble forms in the umbilical cord blood in infants with documented chorioamnionitis. Umbilical cord blood samples were obtained from 10 healthy term newborns,10 noninfected preterm infants, 10 preterm infants with premature rupture of membranes and 9 preterm infants with clinical and histological CA. The expression of CD40L and P

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Dong, Xiaohui, and Xifeng Lv. "Stromal Cell-Derived Factor (SDF)-1-Pretreated Bone Marrow Mesenchymal Stem Cells (BMSCs) Ameliorates Acute Kidney Injury in Mice." Journal of Biomaterials and Tissue Engineering 11, no. 7 (2021): 1255–62. http://dx.doi.org/10.1166/jbt.2021.2701.

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To explore the effects of stromal cell-derived factor (SDF-1) pretreatment of bone marrow mesenchymal stem cells (BMSCs) on acute kidney injury (AKI) in mice. BMSCs were cultured and treated with SDF-1 to detect osteogenic and adipogenic ability. Cisplatin (20 mg/kg) was used to establish AKI model and then divided into blank group, control group 2 (BMSCs injection), and experimental group (intraperitoneal injection of BMSCs treated with SDF-1 (80 ng/ml)) followed by analysis of serum cytokines (Toll like receptor 4 (TLR4), tumor necrosis factor-α (TNF-α), and interleukine-6 (IL-6)) by enzyme

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Valibeik, Ali, Negar Naderi, Abdolhakim Amini, et al. "Effect of camphor on biochemical factors and gene expression of antioxidant enzymes, inflammatory and apoptotic factors against gentamicin-induced nephrotoxicity in rats." Journal of Renal Injury Prevention 10, no. 3 (2020): e21-e21. http://dx.doi.org/10.34172/jrip.2021.21.

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Introduction: Camphor is a natural antioxidant with anti-inflammatory and tissue repair properties. Nephrotoxicity is the most important side effect of gentamicin (GEM) administration. Therefore, investigating the effect of natural antioxidants can resolve this complication. Objectives: We aimed to assay the effect of camphor on biochemical factors and gene expression of antioxidant enzymes (catalase [CAT], glutathione peroxidase [GPX]) and inflammatory markers (tumor necrosis factor-alpha [TNF-α], nuclear factor kappa-B [NF-κB], interleukine-6 [IL-6]), and apoptotic indices (BCL2-associated X

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Tenorio-Jiménez, Carmen, María José Martínez-Ramírez, Ángel Gil, and Carolina Gómez-Llorente. "Effects of Probiotics on Metabolic Syndrome: A Systematic Review of Randomized Clinical Trials." Nutrients 12, no. 1 (2020): 124. http://dx.doi.org/10.3390/nu12010124.

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The aim of this systematic review is to evaluate whether the use of probiotics has any effect on the components of metabolic syndrome (MetS) before patients develop type 2 diabetes. A qualitative systematic review, following the Cochrane methodology, and a comprehensive literature search of randomized controlled trials (RCTs) were conducted in PubMed and Scopus from inception until 4 July 2019. According to our inclusion criteria, nine clinical studies were finally analyzed, corresponding to six RCTs. Probiotics intake in patients with MetS resulted in improvements in body mass index, blood pr

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Lauridsen, Charlotte, Anna Amanda Schönherz, and Søren Højsgaard. "Effect of Maternal Dietary Redox Levels on Antioxidative Status and Immunity of the Suckling Off-Spring." Antioxidants 10, no. 3 (2021): 478. http://dx.doi.org/10.3390/antiox10030478.

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This study investigates two levels of dietary selenium (Se) and vitamin E in combination on their status in sows and their progeny, and influence on antioxidant status and immunological responses of the piglets at weaning. Female pigs (n = 6) were provided LOW or HIGH antioxidant nutrition (Se and vitamin E) from mating until weaning of their off-spring. The HIGH treatment elevated the concentration of Se (p = 0.015) and α-tocopherol (p = 0.023) in plasma of piglets compared with piglets of the LOW treatment. Treatments also affected the concentrations of milk and sow plasma immunoglobulins. P

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Singh, Mhaveer, Mohammad Ahmed Khan, Kamal Y. T., et al. "Effect of Nardostachys jatamansi DC. on Apoptosis, Inflammation and Oxidative Stress Induced by Doxorubicin in Wistar Rats." Plants 9, no. 11 (2020): 1579. http://dx.doi.org/10.3390/plants9111579.

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The study aimed to investigate the protective action of jatamansi (Nardostachys jatamansi DC.) against doxorubicin cardiotoxicity. Methanolic extract of jatamansi (MEJ) was prepared and standardized using HPTLC fingerprinting, GC-MS chemoprofiling, total phenolic content, and antioxidant activity in vitro. Further in vivo activity was evaluated using rodent model. Animals were divided into five groups (n = 6) namely control (CNT) (Normal saline), toxicant (TOX, without any treatment), MEJ at low dose (JAT1), MEJ at high dose (JAT2), and standard desferrioxamine (STD). All groups except control

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Fleury, Vanessa, Alkisti Zekeridou, Vladimir Lazarevic, et al. "Oral Dysbiosis and Inflammation in Parkinson’s Disease." Journal of Parkinson's Disease 11, no. 2 (2021): 619–31. http://dx.doi.org/10.3233/jpd-202459.

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Background: Oral microbiota has largely escaped attention in Parkinson’s disease (PD), despite its pivotal role in maintaining oral and systemic health. Objective: The aim of our study was to examine the composition of the oral microbiota and the degree of oral inflammation in PD. Methods: Twenty PD patients were compared to 20 healthy controls. Neurological, periodontal and dental examinations were performed as well as dental scaling and gingival crevicular fluid sampling for cytokines measurement (interleukine (IL)-1β, IL-6, IL-1 receptor antagonist (RA), interferon-γ and tumor necrosis fact

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34

Hedar, Ahmed M., Martin H. Stradner, Andreas Roessler, and Nandu Goswami. "Autoimmune Rheumatic Diseases and Vascular Function: The Concept of Autoimmune Atherosclerosis." Journal of Clinical Medicine 10, no. 19 (2021): 4427. http://dx.doi.org/10.3390/jcm10194427.

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Autoimmune rheumatic diseases (AIRDs) with unknown etiology are increasing in incidence and prevalence. Up to 5% of the population is affected. AIRDs include rheumatoid arthritis, system lupus erythematosus, systemic sclerosis, and Sjögren’s syndrome. In patients with autoimmune diseases, the immune system attacks structures of its own body, leading to widespread tissue and organ damage, which, in turn, is associated with increased morbidity and mortality. One third of the mortality associated with autoimmune diseases is due to cardiovascular diseases. Atherosclerosis is considered the main un

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35

HIRANO, TOSHIO. "Interleukin 6 (IL-6) and disease." Japanese Journal of Clinical Immunology 13, no. 5 (1990): 444–45. http://dx.doi.org/10.2177/jsci.13.444.

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36

Hansen, MB, M. Svenson, M. Diamant, C. Ross, and K. Bendtzen. "Interleukin-6 (IL-6) autoantibodies and blood IL-6 measurements [letter]." Blood 85, no. 4 (1995): 1145. http://dx.doi.org/10.1182/blood.v85.4.1145.bloodjournal8541145.

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37

Tanaka, Toshio, Masashi Narazaki, and Tadamitsu Kishimoto. "Interleukin (IL-6) Immunotherapy." Cold Spring Harbor Perspectives in Biology 10, no. 8 (2017): a028456. http://dx.doi.org/10.1101/cshperspect.a028456.

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38

Toshiro, Shimamura, Taki Shinsuke, Honda Hideo, Yokota Masataka, Ito Satoru, and Takahara Yoshiyuki. "Analysis of interleukin 6 (IL-6)/IL-6 receptor system using monoclonal anti-IL-6 antibodies." Molecular Immunology 28, no. 11 (1991): 1155–61. http://dx.doi.org/10.1016/0161-5890(91)90001-z.

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39

Rincon, Mercedes. "Special issue on Interleukin-6 (IL-6)." International Journal of Biological Sciences 8, no. 9 (2012): 1225–26. http://dx.doi.org/10.7150/ijbs.8.1225.

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40

GUERNE, P.-A., J. H. VAUGHAN, D. A. CARSON, B. TERKELTAUB, and M. LOTZ. "Interleukin-6 (IL-6) and Joint Tissues." Annals of the New York Academy of Sciences 557, no. 1 (2008): 558–61. http://dx.doi.org/10.1111/j.1749-6632.1989.tb24065.x.

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41

Whisman, Mark A., and David A. Sbarra. "Marital adjustment and interleukin-6 (IL-6)." Journal of Family Psychology 26, no. 2 (2012): 290–95. http://dx.doi.org/10.1037/a0026902.

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42

Chávez-Morales, RM, F. Jaramillo-Juárez, FA Posadas del Río, MA Reyes-Romero, ML Rodríguez-Vázquez, and MC Martínez-Saldaña. "Protective effect of Ginkgo biloba extract on liver damage by a single dose of CCl 4 in male rats." Human & Experimental Toxicology 30, no. 3 (2010): 209–16. http://dx.doi.org/10.1177/0960327110371698.

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Functional and morphological alterations were generated by p.o. (per os) administration of a single oral dose of carbon tetrachloride (CCl4; 0.125 mL/kg b.w., equivalent to 293 mg/kg) to adult male Wistar rats. CCl4 significantly increased (p < 0.05) the serum activities of alanine aminotransferase (ALT; 7478 ± 1044%) and aspartate aminotransferase (AST; 6964 ± 833%), compared to control rats; CCl4 also significantly decreased serum concentration of albumin (23 ± 5.5%) and increased the concentration of malondialhdeyde (MDA) in liver (300 ± 33%). Furthermore, CCl 4 down-regulated the mRNA s

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43

Espinoza-Culupú, Abraham, Ricardo Vázquez-Ramírez, Mariella Farfán-López, et al. "Acylpolyamine Mygalin as a TLR4 Antagonist Based on Molecular Docking and In Vitro Analyses." Biomolecules 10, no. 12 (2020): 1624. http://dx.doi.org/10.3390/biom10121624.

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Toll-like receptors (TLRs) are transmembrane proteins that are key regulators of innate and adaptive immune responses, particularly TLR4, and they have been identified as potential drug targets for the treatment of disease. Several low-molecular-weight compounds are being considered as new drug targets for various applications, including as immune modulators. Mygalin, a 417 Da synthetic bis-acylpolyamine, is an analog of spermidine that has microbicidal activity. In this study, we investigated the effect of mygalin on the innate immune response based on a virtual screening (VS) and molecular d

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44

Qiu, Huiying, Yongquan Xue, Jinlan Pan, Yafang Wu, and Yong Wang. "The Establishment and Characterization of a Human Acute Myelocytic Leukemia Cell Line, SH-2 Carrying t(16;17))(q24;q12) Translocation." Blood 110, no. 11 (2007): 4128. http://dx.doi.org/10.1182/blood.v110.11.4128.4128.

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Abstract We report the establishment of a novel cell line from a patient with acute myelocytic leukemia. The initial growth of this cell line was dependent on the presence of the stromal cell and cytokine interleukine 3. Subsequently, a stroma and cytokine-independent cell line was established, named SH-2. The cell line has proliferated continuously in vitro for more than 24 months. The SH-2 cell line showed identical chromosomal alterations to that of the initial bone marrow aspiration specimen, demonstrated a t(16;17))(q24;q12) translocation accompanied by deletions of y and 17 and triple 19

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45

Metz, Silke, Monique Wiesinger, Michael Vogt, et al. "Characterization of the Interleukin (IL)-6 Inhibitor IL-6-RFP." Journal of Biological Chemistry 282, no. 2 (2006): 1238–48. http://dx.doi.org/10.1074/jbc.m606885200.

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46

Gadient, R. A., and U. Otten. "Differential expression of interleukin-6 (IL-6) and interleukin-6 receptor (IL-6R) mRNAs in rat hypothalamus." Neuroscience Letters 153, no. 1 (1993): 13–16. http://dx.doi.org/10.1016/0304-3940(93)90065-s.

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NISHIMOTO, Norihiro. "2. Interleukin-6 Targeting Biologic Agent." Rinsho yakuri/Japanese Journal of Clinical Pharmacology and Therapeutics 44, no. 1 (2013): 9–14. http://dx.doi.org/10.3999/jscpt.44.9.

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Nishino, Hiroshi. "Interleukin-6 affects cancer cell biology." Journal of Japan Society of Immunology & Allergology in Otolaryngology 34, no. 1 (2016): 13–18. http://dx.doi.org/10.5648/jjiao.34.13.

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49

Baran, Paul, Rebecca Nitz, Joachim Grötzinger, Jürgen Scheller, and Christoph Garbers. "Minimal Interleukin 6 (IL-6) Receptor Stalk Composition for IL-6 Receptor Shedding and IL-6 Classic Signaling." Journal of Biological Chemistry 288, no. 21 (2013): 14756–68. http://dx.doi.org/10.1074/jbc.m113.466169.

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50

Van Wagoner, Nicholas J., Jae-Wook Oh, Pavle Repovic, and Etty N. Benveniste. "Interleukin-6 (IL-6) Production by Astrocytes: Autocrine Regulation by IL-6 and the Soluble IL-6 Receptor." Journal of Neuroscience 19, no. 13 (1999): 5236–44. http://dx.doi.org/10.1523/jneurosci.19-13-05236.1999.

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